| Dataset | MEP.MEP.ery_Pheno.cls #Group1_versus_Group3.MEP.ery_Pheno.cls #Group1_versus_Group3_repos |
| Phenotype | MEP.ery_Pheno.cls#Group1_versus_Group3_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | -0.30572578 |
| Normalized Enrichment Score (NES) | -1.2080939 |
| Nominal p-value | 0.27809525 |
| FDR q-value | 0.60763997 |
| FWER p-Value | 0.932 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Hmbs | 397 | 0.628 | 0.0009 | No |
| 2 | Mcm2 | 1627 | 0.422 | -0.0337 | No |
| 3 | Mcm4 | 1686 | 0.417 | -0.0256 | No |
| 4 | Ppp1r15a | 1842 | 0.399 | -0.0215 | No |
| 5 | Hspd1 | 2411 | 0.360 | -0.0334 | No |
| 6 | Canx | 2467 | 0.357 | -0.0267 | No |
| 7 | Hspa4 | 2607 | 0.345 | -0.0234 | No |
| 8 | Hspa9 | 2637 | 0.343 | -0.0161 | No |
| 9 | Idi1 | 2693 | 0.338 | -0.0098 | No |
| 10 | Tfrc | 3025 | 0.322 | -0.0140 | No |
| 11 | Cdc25a | 3474 | 0.296 | -0.0231 | No |
| 12 | Rpa1 | 3485 | 0.296 | -0.0163 | No |
| 13 | Gga2 | 3543 | 0.293 | -0.0112 | No |
| 14 | Aurka | 3698 | 0.285 | -0.0099 | No |
| 15 | Ero1a | 3705 | 0.284 | -0.0031 | No |
| 16 | Abcf2 | 3841 | 0.281 | -0.0012 | No |
| 17 | Edem1 | 3854 | 0.280 | 0.0052 | No |
| 18 | Bub1 | 4674 | 0.243 | -0.0187 | No |
| 19 | Stc1 | 4970 | 0.229 | -0.0239 | No |
| 20 | Btg2 | 5156 | 0.225 | -0.0251 | No |
| 21 | Tbk1 | 5273 | 0.222 | -0.0239 | No |
| 22 | Eno1b | 5287 | 0.222 | -0.0190 | No |
| 23 | Fads1 | 5309 | 0.221 | -0.0144 | No |
| 24 | Stip1 | 5430 | 0.215 | -0.0135 | No |
| 25 | Rrm2 | 5449 | 0.215 | -0.0089 | No |
| 26 | Gmps | 5467 | 0.214 | -0.0043 | No |
| 27 | Pgk1 | 5949 | 0.197 | -0.0170 | No |
| 28 | Acly | 6128 | 0.190 | -0.0189 | No |
| 29 | Rab1a | 6405 | 0.179 | -0.0246 | No |
| 30 | Ssr1 | 6442 | 0.178 | -0.0215 | No |
| 31 | Uso1 | 6534 | 0.175 | -0.0206 | No |
| 32 | Gbe1 | 6756 | 0.168 | -0.0246 | No |
| 33 | Etf1 | 7077 | 0.156 | -0.0324 | No |
| 34 | Serpinh1 | 7183 | 0.155 | -0.0325 | No |
| 35 | Igfbp5 | 7551 | 0.148 | -0.0422 | No |
| 36 | Pno1 | 7581 | 0.147 | -0.0397 | No |
| 37 | Rrp9 | 7884 | 0.137 | -0.0474 | No |
| 38 | Gclc | 8079 | 0.132 | -0.0512 | No |
| 39 | Insig1 | 8085 | 0.132 | -0.0482 | No |
| 40 | Atp2a2 | 8299 | 0.126 | -0.0529 | No |
| 41 | Nufip1 | 8312 | 0.126 | -0.0503 | No |
| 42 | Ddx39a | 8465 | 0.120 | -0.0529 | No |
| 43 | Gla | 8532 | 0.118 | -0.0524 | No |
| 44 | Nfyc | 8580 | 0.117 | -0.0513 | No |
| 45 | Serp1 | 8749 | 0.112 | -0.0547 | No |
| 46 | Ung | 8762 | 0.111 | -0.0524 | No |
| 47 | Immt | 8786 | 0.110 | -0.0505 | No |
| 48 | Asns | 8793 | 0.110 | -0.0480 | No |
| 49 | Mthfd2l | 8884 | 0.108 | -0.0487 | No |
| 50 | Nampt | 8982 | 0.105 | -0.0497 | No |
| 51 | P4ha1 | 9147 | 0.100 | -0.0532 | No |
| 52 | Me1 | 9195 | 0.099 | -0.0525 | No |
| 53 | Actr3 | 9272 | 0.097 | -0.0529 | No |
| 54 | Sytl2 | 9305 | 0.096 | -0.0518 | No |
| 55 | Cct6a | 9486 | 0.090 | -0.0561 | No |
| 56 | Stard4 | 9498 | 0.090 | -0.0543 | No |
| 57 | Psmc4 | 9643 | 0.085 | -0.0575 | No |
| 58 | Gsk3b | 9865 | 0.079 | -0.0636 | No |
| 59 | Ddit4 | 9901 | 0.078 | -0.0630 | No |
| 60 | Ppia | 9946 | 0.077 | -0.0628 | No |
| 61 | Ccnf | 10085 | 0.073 | -0.0660 | No |
| 62 | Pik3r3 | 10178 | 0.070 | -0.0677 | No |
| 63 | Nup205 | 10383 | 0.064 | -0.0735 | No |
| 64 | Ifrd1 | 10402 | 0.063 | -0.0727 | No |
| 65 | Hsp90b1 | 10476 | 0.061 | -0.0738 | No |
| 66 | Pitpnb | 10839 | 0.051 | -0.0858 | No |
| 67 | Psmc2 | 10927 | 0.048 | -0.0878 | No |
| 68 | Bcat1 | 11125 | 0.043 | -0.0939 | No |
| 69 | Fads2 | 11236 | 0.040 | -0.0970 | No |
| 70 | Acsl3 | 11470 | 0.033 | -0.1047 | No |
| 71 | Psmd14 | 11635 | 0.029 | -0.1100 | No |
| 72 | Actr2 | 11649 | 0.029 | -0.1097 | No |
| 73 | Dhfr | 11685 | 0.028 | -0.1103 | No |
| 74 | Fdxr | 11756 | 0.027 | -0.1122 | No |
| 75 | Pfkl | 11762 | 0.026 | -0.1118 | No |
| 76 | Pnp | 11868 | 0.024 | -0.1150 | No |
| 77 | Pdk1 | 12006 | 0.021 | -0.1195 | No |
| 78 | Uchl5 | 12092 | 0.018 | -0.1222 | No |
| 79 | Ykt6 | 12158 | 0.017 | -0.1241 | No |
| 80 | Tcea1 | 13245 | -0.003 | -0.1637 | No |
| 81 | Wars1 | 13277 | -0.004 | -0.1647 | No |
| 82 | Nmt1 | 13307 | -0.005 | -0.1657 | No |
| 83 | Hmgcr | 13378 | -0.006 | -0.1681 | No |
| 84 | Psme3 | 13546 | -0.011 | -0.1739 | No |
| 85 | Ufm1 | 13773 | -0.018 | -0.1817 | No |
| 86 | Psmc6 | 13789 | -0.018 | -0.1818 | No |
| 87 | Ube2d3 | 14041 | -0.025 | -0.1904 | No |
| 88 | Sord | 14058 | -0.026 | -0.1903 | No |
| 89 | Lta4h | 14125 | -0.028 | -0.1921 | No |
| 90 | Sqle | 14237 | -0.031 | -0.1954 | No |
| 91 | Srd5a1 | 14329 | -0.034 | -0.1979 | No |
| 92 | Plk1 | 14604 | -0.041 | -0.2069 | No |
| 93 | Hspa5 | 14676 | -0.043 | -0.2084 | No |
| 94 | Slc2a3 | 14738 | -0.045 | -0.2095 | No |
| 95 | Ddit3 | 14777 | -0.046 | -0.2098 | No |
| 96 | Got1 | 14828 | -0.048 | -0.2104 | No |
| 97 | Cxcr4 | 15179 | -0.058 | -0.2218 | No |
| 98 | G6pdx | 15267 | -0.061 | -0.2235 | No |
| 99 | Slc1a5 | 15338 | -0.063 | -0.2245 | No |
| 100 | Acaca | 15359 | -0.064 | -0.2236 | No |
| 101 | Tm7sf2 | 15420 | -0.066 | -0.2242 | No |
| 102 | Skap2 | 15447 | -0.066 | -0.2235 | No |
| 103 | Psmd13 | 15494 | -0.068 | -0.2236 | No |
| 104 | Rpn1 | 15522 | -0.069 | -0.2229 | No |
| 105 | Mllt11 | 15929 | -0.080 | -0.2357 | No |
| 106 | Eef1e1 | 15978 | -0.082 | -0.2355 | No |
| 107 | Calr | 16227 | -0.087 | -0.2424 | No |
| 108 | Elovl6 | 16328 | -0.090 | -0.2439 | No |
| 109 | Gtf2h1 | 16580 | -0.098 | -0.2506 | No |
| 110 | Idh1 | 16588 | -0.099 | -0.2484 | No |
| 111 | Cyb5b | 16647 | -0.101 | -0.2481 | No |
| 112 | M6pr | 16701 | -0.102 | -0.2475 | No |
| 113 | Polr3g | 16885 | -0.108 | -0.2516 | No |
| 114 | Adipor2 | 17199 | -0.118 | -0.2601 | No |
| 115 | Dhcr7 | 17516 | -0.125 | -0.2686 | No |
| 116 | Pdap1 | 17618 | -0.129 | -0.2691 | No |
| 117 | Psma3 | 17676 | -0.131 | -0.2680 | No |
| 118 | Gsr | 17825 | -0.135 | -0.2701 | No |
| 119 | Plod2 | 17881 | -0.137 | -0.2688 | No |
| 120 | Atp6v1d | 17901 | -0.138 | -0.2661 | No |
| 121 | Tes | 18569 | -0.156 | -0.2866 | No |
| 122 | Rdh11 | 18578 | -0.157 | -0.2831 | No |
| 123 | Add3 | 18647 | -0.158 | -0.2817 | No |
| 124 | Elovl5 | 18656 | -0.159 | -0.2781 | No |
| 125 | Sqstm1 | 18665 | -0.159 | -0.2745 | No |
| 126 | Ccng1 | 19096 | -0.173 | -0.2860 | No |
| 127 | Eif2s2 | 19100 | -0.173 | -0.2819 | No |
| 128 | Txnrd1 | 19126 | -0.174 | -0.2785 | No |
| 129 | Cyp51 | 19136 | -0.175 | -0.2746 | No |
| 130 | Gpi1 | 19155 | -0.175 | -0.2710 | No |
| 131 | Psmd12 | 19327 | -0.182 | -0.2728 | No |
| 132 | Map2k3 | 19348 | -0.182 | -0.2690 | No |
| 133 | Hspe1 | 19606 | -0.192 | -0.2737 | No |
| 134 | Pgm1 | 19673 | -0.195 | -0.2714 | No |
| 135 | Dapp1 | 19906 | -0.204 | -0.2749 | No |
| 136 | Sc5d | 20063 | -0.208 | -0.2755 | No |
| 137 | Dhcr24 | 20404 | -0.216 | -0.2826 | No |
| 138 | Slc2a1 | 21039 | -0.237 | -0.2999 | Yes |
| 139 | Sec11a | 21047 | -0.237 | -0.2944 | Yes |
| 140 | Fgl2 | 21290 | -0.247 | -0.2972 | Yes |
| 141 | Mthfd2 | 21300 | -0.248 | -0.2915 | Yes |
| 142 | Ppa1 | 21385 | -0.251 | -0.2884 | Yes |
| 143 | Tpi1 | 21416 | -0.252 | -0.2833 | Yes |
| 144 | Hk2 | 21430 | -0.253 | -0.2776 | Yes |
| 145 | Slc37a4 | 21500 | -0.256 | -0.2739 | Yes |
| 146 | Cacybp | 21751 | -0.264 | -0.2766 | Yes |
| 147 | Ak4 | 21755 | -0.264 | -0.2702 | Yes |
| 148 | Slc6a6 | 21905 | -0.267 | -0.2692 | Yes |
| 149 | Slc7a5 | 21912 | -0.267 | -0.2629 | Yes |
| 150 | Tomm40 | 21918 | -0.267 | -0.2565 | Yes |
| 151 | Aldoa | 22042 | -0.272 | -0.2543 | Yes |
| 152 | Itgb2 | 22167 | -0.278 | -0.2521 | Yes |
| 153 | Tmem97 | 22435 | -0.290 | -0.2547 | Yes |
| 154 | Qdpr | 22649 | -0.300 | -0.2552 | Yes |
| 155 | Cfp | 22800 | -0.301 | -0.2533 | Yes |
| 156 | Lgmn | 22807 | -0.301 | -0.2462 | Yes |
| 157 | Slc1a4 | 23186 | -0.320 | -0.2522 | Yes |
| 158 | Cops5 | 23354 | -0.327 | -0.2503 | Yes |
| 159 | Nupr1 | 23453 | -0.332 | -0.2457 | Yes |
| 160 | Prdx1 | 23464 | -0.333 | -0.2380 | Yes |
| 161 | Xbp1 | 23470 | -0.333 | -0.2300 | Yes |
| 162 | Hmgcs1 | 23491 | -0.334 | -0.2226 | Yes |
| 163 | Psat1 | 23494 | -0.334 | -0.2145 | Yes |
| 164 | Arpc5l | 23671 | -0.341 | -0.2126 | Yes |
| 165 | Glrx | 23691 | -0.342 | -0.2050 | Yes |
| 166 | Psma4 | 23776 | -0.346 | -0.1996 | Yes |
| 167 | Bhlhe40 | 23792 | -0.347 | -0.1916 | Yes |
| 168 | Nfil3 | 24005 | -0.360 | -0.1906 | Yes |
| 169 | Cd9 | 24044 | -0.362 | -0.1831 | Yes |
| 170 | Tubg1 | 24082 | -0.365 | -0.1755 | Yes |
| 171 | Nfkbib | 24265 | -0.376 | -0.1730 | Yes |
| 172 | Psph | 24315 | -0.379 | -0.1655 | Yes |
| 173 | Sla | 24320 | -0.380 | -0.1564 | Yes |
| 174 | Phgdh | 24333 | -0.380 | -0.1476 | Yes |
| 175 | Egln3 | 24646 | -0.396 | -0.1493 | Yes |
| 176 | Tuba4a | 24692 | -0.398 | -0.1412 | Yes |
| 177 | Ifi30 | 24861 | -0.409 | -0.1373 | Yes |
| 178 | Slc7a11 | 25263 | -0.431 | -0.1414 | Yes |
| 179 | Psmg1 | 25512 | -0.448 | -0.1395 | Yes |
| 180 | Shmt2 | 25530 | -0.448 | -0.1292 | Yes |
| 181 | Vldlr | 25562 | -0.451 | -0.1193 | Yes |
| 182 | Ldlr | 25701 | -0.464 | -0.1130 | Yes |
| 183 | Trib3 | 25830 | -0.471 | -0.1062 | Yes |
| 184 | Fkbp2 | 26101 | -0.501 | -0.1038 | Yes |
| 185 | Psmb5 | 26218 | -0.513 | -0.0955 | Yes |
| 186 | Ldha | 26283 | -0.523 | -0.0851 | Yes |
| 187 | Ctsc | 26298 | -0.525 | -0.0728 | Yes |
| 188 | Coro1a | 26534 | -0.561 | -0.0677 | Yes |
| 189 | Rit1 | 26634 | -0.575 | -0.0572 | Yes |
| 190 | Niban1 | 27012 | -0.641 | -0.0553 | Yes |
| 191 | Cth | 27145 | -0.680 | -0.0435 | Yes |
| 192 | Cdkn1a | 27165 | -0.686 | -0.0275 | Yes |
| 193 | Ebp | 27480 | -0.864 | -0.0178 | Yes |
| 194 | Sdf2l1 | 27528 | -0.912 | 0.0027 | Yes |

