| Dataset | HSC.HSC_Pheno.cls#Group3_versus_Group4.HSC_Pheno.cls#Group3_versus_Group4_repos |
| Phenotype | HSC_Pheno.cls#Group3_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | -0.1551924 |
| Normalized Enrichment Score (NES) | -0.7219815 |
| Nominal p-value | 0.9802371 |
| FDR q-value | 0.9815363 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Arpc5l | 83 | 0.883 | 0.0138 | No |
| 2 | Gsk3b | 239 | 0.708 | 0.0176 | No |
| 3 | Immt | 309 | 0.671 | 0.0276 | No |
| 4 | Pdap1 | 359 | 0.650 | 0.0387 | No |
| 5 | Coro1a | 451 | 0.609 | 0.0454 | No |
| 6 | Niban1 | 463 | 0.607 | 0.0587 | No |
| 7 | Cd9 | 481 | 0.601 | 0.0713 | No |
| 8 | Pno1 | 512 | 0.592 | 0.0826 | No |
| 9 | Tfrc | 693 | 0.546 | 0.0806 | No |
| 10 | Psma4 | 743 | 0.535 | 0.0890 | No |
| 11 | Stard4 | 756 | 0.531 | 0.1004 | No |
| 12 | Psme3 | 1113 | 0.466 | 0.0821 | No |
| 13 | Mthfd2 | 1144 | 0.462 | 0.0904 | No |
| 14 | Hspa5 | 1227 | 0.450 | 0.0942 | No |
| 15 | Tomm40 | 1246 | 0.447 | 0.1031 | No |
| 16 | Psmd12 | 1439 | 0.419 | 0.0971 | No |
| 17 | Add3 | 1444 | 0.418 | 0.1066 | No |
| 18 | Got1 | 1451 | 0.418 | 0.1158 | No |
| 19 | Fgl2 | 1529 | 0.411 | 0.1191 | No |
| 20 | Cxcr4 | 1579 | 0.404 | 0.1245 | No |
| 21 | Hmgcs1 | 1983 | 0.352 | 0.0996 | No |
| 22 | Psmc6 | 2036 | 0.348 | 0.1035 | No |
| 23 | Ldlr | 2151 | 0.336 | 0.1019 | No |
| 24 | Dapp1 | 2182 | 0.333 | 0.1072 | No |
| 25 | Cct6a | 2219 | 0.329 | 0.1119 | No |
| 26 | Egln3 | 2246 | 0.326 | 0.1174 | No |
| 27 | Bub1 | 2310 | 0.320 | 0.1197 | No |
| 28 | Ppa1 | 2423 | 0.308 | 0.1177 | No |
| 29 | Actr3 | 2499 | 0.303 | 0.1186 | No |
| 30 | Atp6v1d | 2585 | 0.295 | 0.1185 | No |
| 31 | Slc7a5 | 2626 | 0.292 | 0.1220 | No |
| 32 | Hspe1 | 2661 | 0.289 | 0.1260 | No |
| 33 | Pitpnb | 2692 | 0.286 | 0.1302 | No |
| 34 | Hmbs | 2875 | 0.274 | 0.1216 | No |
| 35 | Nfkbib | 2960 | 0.265 | 0.1209 | No |
| 36 | Atp2a2 | 2972 | 0.264 | 0.1262 | No |
| 37 | Tuba4a | 2988 | 0.263 | 0.1311 | No |
| 38 | Ebp | 3013 | 0.261 | 0.1352 | No |
| 39 | Rit1 | 3087 | 0.257 | 0.1352 | No |
| 40 | Nufip1 | 3113 | 0.253 | 0.1390 | No |
| 41 | Slc2a1 | 3167 | 0.250 | 0.1405 | No |
| 42 | Serpinh1 | 3273 | 0.240 | 0.1375 | No |
| 43 | Ddit4 | 3381 | 0.232 | 0.1341 | No |
| 44 | Nup205 | 3428 | 0.226 | 0.1356 | No |
| 45 | Cdc25a | 3468 | 0.225 | 0.1376 | No |
| 46 | Gtf2h1 | 3482 | 0.224 | 0.1418 | No |
| 47 | Gmps | 3585 | 0.214 | 0.1384 | No |
| 48 | Rab1a | 3860 | 0.195 | 0.1205 | No |
| 49 | Cfp | 3922 | 0.190 | 0.1199 | No |
| 50 | Rrm2 | 3925 | 0.190 | 0.1241 | No |
| 51 | Pgm1 | 3970 | 0.187 | 0.1249 | No |
| 52 | Nmt1 | 4030 | 0.183 | 0.1243 | No |
| 53 | G6pdx | 4044 | 0.181 | 0.1275 | No |
| 54 | Aurka | 4129 | 0.175 | 0.1247 | No |
| 55 | Calr | 4137 | 0.174 | 0.1281 | No |
| 56 | Glrx | 4166 | 0.172 | 0.1299 | No |
| 57 | Slc6a6 | 4265 | 0.164 | 0.1257 | No |
| 58 | Me1 | 4304 | 0.161 | 0.1263 | No |
| 59 | Skap2 | 4373 | 0.156 | 0.1244 | No |
| 60 | Trib3 | 4407 | 0.153 | 0.1252 | No |
| 61 | Hk2 | 4427 | 0.152 | 0.1272 | No |
| 62 | Dhcr24 | 4436 | 0.151 | 0.1301 | No |
| 63 | Hmgcr | 4465 | 0.149 | 0.1313 | No |
| 64 | Ccng1 | 4473 | 0.149 | 0.1342 | No |
| 65 | Tubg1 | 4491 | 0.148 | 0.1362 | No |
| 66 | Prdx1 | 4640 | 0.137 | 0.1273 | No |
| 67 | Hspd1 | 4658 | 0.136 | 0.1290 | No |
| 68 | Vldlr | 4814 | 0.125 | 0.1192 | No |
| 69 | Rrp9 | 4829 | 0.125 | 0.1210 | No |
| 70 | Psmd14 | 4859 | 0.123 | 0.1215 | No |
| 71 | Gsr | 4918 | 0.119 | 0.1195 | No |
| 72 | Sqle | 5039 | 0.110 | 0.1122 | No |
| 73 | Tbk1 | 5075 | 0.108 | 0.1119 | No |
| 74 | Cyb5b | 5338 | 0.089 | 0.0924 | No |
| 75 | Acsl3 | 5360 | 0.087 | 0.0927 | No |
| 76 | P4ha1 | 5379 | 0.085 | 0.0932 | No |
| 77 | Pfkl | 5458 | 0.080 | 0.0887 | No |
| 78 | Lta4h | 5492 | 0.078 | 0.0878 | No |
| 79 | Mcm4 | 5585 | 0.071 | 0.0819 | No |
| 80 | Cyp51 | 5607 | 0.069 | 0.0818 | No |
| 81 | Psma3 | 5617 | 0.068 | 0.0827 | No |
| 82 | Serp1 | 5677 | 0.064 | 0.0793 | No |
| 83 | Ero1a | 5830 | 0.053 | 0.0681 | No |
| 84 | Ddx39a | 5856 | 0.051 | 0.0672 | No |
| 85 | Mcm2 | 5871 | 0.050 | 0.0672 | No |
| 86 | Phgdh | 6318 | 0.022 | 0.0312 | No |
| 87 | Cops5 | 6413 | 0.014 | 0.0238 | No |
| 88 | Aldoa | 6445 | 0.012 | 0.0215 | No |
| 89 | Sord | 6512 | 0.008 | 0.0163 | No |
| 90 | Ube2d3 | 6576 | 0.005 | 0.0112 | No |
| 91 | Eef1e1 | 6620 | 0.001 | 0.0077 | No |
| 92 | Sla | 6819 | -0.006 | -0.0084 | No |
| 93 | Ufm1 | 6895 | -0.011 | -0.0143 | No |
| 94 | Gpi1 | 6925 | -0.013 | -0.0164 | No |
| 95 | Nfyc | 6952 | -0.015 | -0.0182 | No |
| 96 | Pdk1 | 6961 | -0.015 | -0.0185 | No |
| 97 | Srd5a1 | 7014 | -0.020 | -0.0223 | No |
| 98 | Idh1 | 7076 | -0.023 | -0.0267 | No |
| 99 | Mthfd2l | 7100 | -0.025 | -0.0280 | No |
| 100 | Rpa1 | 7112 | -0.026 | -0.0283 | No |
| 101 | Dhcr7 | 7177 | -0.029 | -0.0329 | No |
| 102 | Sec11a | 7239 | -0.034 | -0.0371 | No |
| 103 | Hsp90b1 | 7257 | -0.036 | -0.0377 | No |
| 104 | Stip1 | 7371 | -0.043 | -0.0459 | No |
| 105 | Ctsc | 7415 | -0.047 | -0.0483 | No |
| 106 | Insig1 | 7451 | -0.050 | -0.0501 | No |
| 107 | Acly | 7461 | -0.051 | -0.0496 | No |
| 108 | Hspa9 | 7498 | -0.053 | -0.0513 | No |
| 109 | Fads1 | 7815 | -0.076 | -0.0755 | No |
| 110 | Ccnf | 8069 | -0.096 | -0.0940 | No |
| 111 | Psat1 | 8078 | -0.097 | -0.0924 | No |
| 112 | Tpi1 | 8085 | -0.098 | -0.0906 | No |
| 113 | Ppp1r15a | 8160 | -0.103 | -0.0942 | No |
| 114 | Ppia | 8175 | -0.105 | -0.0930 | No |
| 115 | Txnrd1 | 8190 | -0.106 | -0.0916 | No |
| 116 | Psmd13 | 8309 | -0.115 | -0.0987 | No |
| 117 | Uso1 | 8313 | -0.115 | -0.0962 | No |
| 118 | Tcea1 | 8373 | -0.120 | -0.0983 | No |
| 119 | Sqstm1 | 8384 | -0.121 | -0.0962 | No |
| 120 | Rdh11 | 8392 | -0.122 | -0.0940 | No |
| 121 | Ifrd1 | 8472 | -0.128 | -0.0975 | No |
| 122 | M6pr | 8494 | -0.129 | -0.0962 | No |
| 123 | Wars1 | 8584 | -0.136 | -0.1003 | No |
| 124 | Gclc | 8632 | -0.141 | -0.1009 | No |
| 125 | Canx | 8770 | -0.153 | -0.1086 | No |
| 126 | Map2k3 | 8784 | -0.156 | -0.1060 | No |
| 127 | Slc1a5 | 8919 | -0.166 | -0.1131 | No |
| 128 | Nampt | 8971 | -0.169 | -0.1134 | No |
| 129 | Acaca | 9050 | -0.174 | -0.1157 | No |
| 130 | Ak4 | 9291 | -0.193 | -0.1309 | No |
| 131 | Adipor2 | 9338 | -0.197 | -0.1301 | No |
| 132 | Psph | 9447 | -0.207 | -0.1341 | No |
| 133 | Slc2a3 | 9579 | -0.221 | -0.1397 | No |
| 134 | Tm7sf2 | 9592 | -0.222 | -0.1355 | No |
| 135 | Ssr1 | 9641 | -0.224 | -0.1342 | No |
| 136 | Ldha | 9777 | -0.236 | -0.1398 | No |
| 137 | Shmt2 | 9818 | -0.241 | -0.1374 | No |
| 138 | Pnp | 9823 | -0.241 | -0.1321 | No |
| 139 | Gbe1 | 9986 | -0.258 | -0.1394 | No |
| 140 | Rpn1 | 10058 | -0.264 | -0.1391 | No |
| 141 | Tes | 10099 | -0.267 | -0.1362 | No |
| 142 | Xbp1 | 10233 | -0.281 | -0.1405 | No |
| 143 | Sc5d | 10300 | -0.287 | -0.1392 | No |
| 144 | Eif2s2 | 10364 | -0.294 | -0.1376 | No |
| 145 | Fads2 | 10516 | -0.313 | -0.1426 | No |
| 146 | Itgb2 | 10670 | -0.329 | -0.1475 | Yes |
| 147 | Bhlhe40 | 10738 | -0.339 | -0.1451 | Yes |
| 148 | Asns | 10741 | -0.339 | -0.1374 | Yes |
| 149 | Etf1 | 10751 | -0.341 | -0.1302 | Yes |
| 150 | Plod2 | 10771 | -0.344 | -0.1237 | Yes |
| 151 | Gga2 | 10832 | -0.352 | -0.1204 | Yes |
| 152 | Elovl6 | 10874 | -0.358 | -0.1154 | Yes |
| 153 | Psmc4 | 10951 | -0.369 | -0.1131 | Yes |
| 154 | Psmb5 | 10968 | -0.371 | -0.1058 | Yes |
| 155 | Hspa4 | 11091 | -0.388 | -0.1067 | Yes |
| 156 | Elovl5 | 11148 | -0.394 | -0.1021 | Yes |
| 157 | Psmg1 | 11150 | -0.394 | -0.0930 | Yes |
| 158 | Dhfr | 11159 | -0.396 | -0.0845 | Yes |
| 159 | Cacybp | 11172 | -0.400 | -0.0761 | Yes |
| 160 | Qdpr | 11216 | -0.404 | -0.0702 | Yes |
| 161 | Psmc2 | 11235 | -0.406 | -0.0622 | Yes |
| 162 | Actr2 | 11295 | -0.417 | -0.0574 | Yes |
| 163 | Fdxr | 11308 | -0.419 | -0.0486 | Yes |
| 164 | Polr3g | 11339 | -0.423 | -0.0412 | Yes |
| 165 | Edem1 | 11597 | -0.470 | -0.0513 | Yes |
| 166 | Ddit3 | 11617 | -0.474 | -0.0418 | Yes |
| 167 | Mllt11 | 11680 | -0.488 | -0.0355 | Yes |
| 168 | Uchl5 | 11904 | -0.548 | -0.0411 | Yes |
| 169 | Abcf2 | 12041 | -0.603 | -0.0382 | Yes |
| 170 | Pgk1 | 12042 | -0.605 | -0.0241 | Yes |
| 171 | Fkbp2 | 12054 | -0.610 | -0.0107 | Yes |
| 172 | Ykt6 | 12143 | -0.662 | -0.0025 | Yes |
| 173 | Nupr1 | 12307 | -0.879 | 0.0046 | Yes |

