| Dataset | HSC.HSC_Pheno.cls#Group1_versus_Group4.HSC_Pheno.cls#Group1_versus_Group4_repos |
| Phenotype | HSC_Pheno.cls#Group1_versus_Group4_repos |
| Upregulated in class | 0 |
| GeneSet | HALLMARK_E2F_TARGETS |
| Enrichment Score (ES) | 0.3230707 |
| Normalized Enrichment Score (NES) | 1.0453326 |
| Nominal p-value | 0.39285713 |
| FDR q-value | 0.61399376 |
| FWER p-Value | 0.999 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Smc1a | 23 | 1.295 | 0.0247 | Yes |
| 2 | Pds5b | 121 | 0.941 | 0.0361 | Yes |
| 3 | Xrcc6 | 125 | 0.931 | 0.0550 | Yes |
| 4 | Rad1 | 130 | 0.923 | 0.0737 | Yes |
| 5 | Pms2 | 237 | 0.799 | 0.0814 | Yes |
| 6 | Mlh1 | 295 | 0.767 | 0.0925 | Yes |
| 7 | Tra2b | 302 | 0.760 | 0.1076 | Yes |
| 8 | Mthfd2 | 354 | 0.733 | 0.1185 | Yes |
| 9 | Hnrnpd | 387 | 0.713 | 0.1306 | Yes |
| 10 | Shmt1 | 411 | 0.700 | 0.1431 | Yes |
| 11 | Cdkn1b | 569 | 0.638 | 0.1433 | Yes |
| 12 | Cdc20 | 637 | 0.616 | 0.1505 | Yes |
| 13 | Rnaseh2a | 647 | 0.613 | 0.1624 | Yes |
| 14 | Pttg1 | 711 | 0.595 | 0.1694 | Yes |
| 15 | Racgap1 | 718 | 0.592 | 0.1811 | Yes |
| 16 | Tacc3 | 842 | 0.563 | 0.1826 | Yes |
| 17 | Ube2s | 870 | 0.559 | 0.1919 | Yes |
| 18 | Hmmr | 962 | 0.540 | 0.1955 | Yes |
| 19 | Rpa2 | 964 | 0.540 | 0.2066 | Yes |
| 20 | Spc25 | 1006 | 0.533 | 0.2141 | Yes |
| 21 | Ak2 | 1100 | 0.515 | 0.2171 | Yes |
| 22 | Hus1 | 1143 | 0.506 | 0.2241 | Yes |
| 23 | Ctcf | 1239 | 0.486 | 0.2263 | Yes |
| 24 | Ipo7 | 1289 | 0.479 | 0.2321 | Yes |
| 25 | Cdk1 | 1303 | 0.476 | 0.2408 | Yes |
| 26 | Pcna | 1450 | 0.452 | 0.2381 | Yes |
| 27 | Gins4 | 1490 | 0.446 | 0.2441 | Yes |
| 28 | Bub1b | 1537 | 0.439 | 0.2494 | Yes |
| 29 | Top2a | 1544 | 0.438 | 0.2579 | Yes |
| 30 | Nop56 | 1591 | 0.432 | 0.2630 | Yes |
| 31 | Smc3 | 1715 | 0.417 | 0.2615 | Yes |
| 32 | Depdc1a | 1741 | 0.415 | 0.2680 | Yes |
| 33 | Kif4 | 1769 | 0.412 | 0.2742 | Yes |
| 34 | Spag5 | 1845 | 0.403 | 0.2763 | Yes |
| 35 | Kif18b | 1999 | 0.385 | 0.2717 | Yes |
| 36 | Rrm2 | 2057 | 0.380 | 0.2748 | Yes |
| 37 | Hmgb2 | 2128 | 0.372 | 0.2767 | Yes |
| 38 | Nasp | 2150 | 0.369 | 0.2826 | Yes |
| 39 | Exosc8 | 2174 | 0.366 | 0.2883 | Yes |
| 40 | Mki67 | 2269 | 0.355 | 0.2878 | Yes |
| 41 | Ssrp1 | 2323 | 0.349 | 0.2907 | Yes |
| 42 | Rfc3 | 2477 | 0.332 | 0.2849 | Yes |
| 43 | Syncrip | 2504 | 0.329 | 0.2896 | Yes |
| 44 | Smc4 | 2516 | 0.328 | 0.2954 | Yes |
| 45 | Rfc1 | 2571 | 0.323 | 0.2976 | Yes |
| 46 | Srsf2 | 2572 | 0.323 | 0.3043 | Yes |
| 47 | Slbp | 2605 | 0.320 | 0.3082 | Yes |
| 48 | Myc | 2754 | 0.303 | 0.3023 | Yes |
| 49 | Paics | 2821 | 0.296 | 0.3030 | Yes |
| 50 | Mcm6 | 2830 | 0.296 | 0.3084 | Yes |
| 51 | Lig1 | 2837 | 0.295 | 0.3140 | Yes |
| 52 | Nup107 | 2942 | 0.286 | 0.3113 | Yes |
| 53 | Pa2g4 | 2943 | 0.286 | 0.3172 | Yes |
| 54 | Ddx39a | 2944 | 0.286 | 0.3231 | Yes |
| 55 | Wee1 | 3050 | 0.273 | 0.3201 | No |
| 56 | Cks2 | 3089 | 0.270 | 0.3225 | No |
| 57 | Birc5 | 3177 | 0.261 | 0.3207 | No |
| 58 | Ran | 3307 | 0.251 | 0.3153 | No |
| 59 | Tfrc | 3433 | 0.241 | 0.3100 | No |
| 60 | Hmgb3 | 3495 | 0.234 | 0.3098 | No |
| 61 | Ccnb2 | 3510 | 0.233 | 0.3134 | No |
| 62 | Srsf1 | 3582 | 0.226 | 0.3123 | No |
| 63 | Psmc3ip | 3633 | 0.224 | 0.3128 | No |
| 64 | Chek2 | 3682 | 0.222 | 0.3134 | No |
| 65 | Cdc25a | 3787 | 0.212 | 0.3092 | No |
| 66 | Mre11a | 3863 | 0.208 | 0.3073 | No |
| 67 | Dek | 3963 | 0.201 | 0.3033 | No |
| 68 | Cenpe | 4046 | 0.194 | 0.3006 | No |
| 69 | Chek1 | 4075 | 0.192 | 0.3022 | No |
| 70 | Pola2 | 4081 | 0.191 | 0.3057 | No |
| 71 | Cbx5 | 4133 | 0.186 | 0.3054 | No |
| 72 | Tk1 | 4141 | 0.185 | 0.3086 | No |
| 73 | Msh2 | 4320 | 0.170 | 0.2975 | No |
| 74 | Prim2 | 4336 | 0.169 | 0.2997 | No |
| 75 | Dut | 4450 | 0.161 | 0.2938 | No |
| 76 | Cit | 4524 | 0.156 | 0.2910 | No |
| 77 | Rad21 | 4730 | 0.140 | 0.2770 | No |
| 78 | Usp1 | 4738 | 0.139 | 0.2793 | No |
| 79 | Brms1l | 4741 | 0.139 | 0.2820 | No |
| 80 | Rbbp7 | 4773 | 0.137 | 0.2823 | No |
| 81 | Rad51ap1 | 4913 | 0.126 | 0.2735 | No |
| 82 | Ilf3 | 4974 | 0.120 | 0.2710 | No |
| 83 | Cdca8 | 4986 | 0.120 | 0.2726 | No |
| 84 | H2az1 | 5025 | 0.117 | 0.2719 | No |
| 85 | Ing3 | 5073 | 0.114 | 0.2704 | No |
| 86 | Ncapd2 | 5084 | 0.113 | 0.2719 | No |
| 87 | Cse1l | 5088 | 0.113 | 0.2740 | No |
| 88 | Lbr | 5195 | 0.104 | 0.2674 | No |
| 89 | Mcm2 | 5324 | 0.096 | 0.2589 | No |
| 90 | Rpa3 | 5386 | 0.091 | 0.2557 | No |
| 91 | Cdkn2c | 5421 | 0.088 | 0.2548 | No |
| 92 | Mms22l | 5557 | 0.078 | 0.2453 | No |
| 93 | Prkdc | 5600 | 0.075 | 0.2434 | No |
| 94 | Mad2l1 | 5625 | 0.073 | 0.2429 | No |
| 95 | Donson | 5681 | 0.070 | 0.2398 | No |
| 96 | Dnmt1 | 5773 | 0.064 | 0.2337 | No |
| 97 | Mcm5 | 5822 | 0.060 | 0.2310 | No |
| 98 | Prps1 | 5825 | 0.060 | 0.2320 | No |
| 99 | Gins3 | 5938 | 0.052 | 0.2239 | No |
| 100 | Nbn | 5960 | 0.050 | 0.2232 | No |
| 101 | Dclre1b | 5981 | 0.048 | 0.2226 | No |
| 102 | Zw10 | 6059 | 0.042 | 0.2171 | No |
| 103 | Tubb5 | 6167 | 0.035 | 0.2090 | No |
| 104 | Gins1 | 6232 | 0.031 | 0.2044 | No |
| 105 | Eed | 6247 | 0.031 | 0.2039 | No |
| 106 | Suv39h1 | 6276 | 0.029 | 0.2022 | No |
| 107 | Plk4 | 6278 | 0.029 | 0.2027 | No |
| 108 | Stag1 | 6300 | 0.027 | 0.2015 | No |
| 109 | Stmn1 | 6313 | 0.026 | 0.2011 | No |
| 110 | Atad2 | 6474 | 0.015 | 0.1883 | No |
| 111 | Rpa1 | 6484 | 0.015 | 0.1878 | No |
| 112 | Nolc1 | 6567 | 0.008 | 0.1813 | No |
| 113 | Dlgap5 | 6649 | 0.004 | 0.1747 | No |
| 114 | Ube2t | 6660 | 0.003 | 0.1740 | No |
| 115 | Cenpm | 6673 | 0.003 | 0.1730 | No |
| 116 | Mcm3 | 6703 | 0.001 | 0.1707 | No |
| 117 | Nap1l1 | 6796 | -0.003 | 0.1632 | No |
| 118 | Rad50 | 6808 | -0.004 | 0.1624 | No |
| 119 | Timeless | 6845 | -0.006 | 0.1595 | No |
| 120 | Pnn | 6860 | -0.007 | 0.1585 | No |
| 121 | Tubg1 | 7300 | -0.037 | 0.1232 | No |
| 122 | Mcm7 | 7415 | -0.046 | 0.1148 | No |
| 123 | Trip13 | 7463 | -0.049 | 0.1120 | No |
| 124 | E2f8 | 7526 | -0.053 | 0.1080 | No |
| 125 | Gspt1 | 7589 | -0.058 | 0.1041 | No |
| 126 | Orc6 | 7638 | -0.061 | 0.1014 | No |
| 127 | Trp53 | 7685 | -0.065 | 0.0990 | No |
| 128 | Diaph3 | 7757 | -0.071 | 0.0946 | No |
| 129 | Mcm4 | 7807 | -0.075 | 0.0921 | No |
| 130 | Pole | 7835 | -0.076 | 0.0915 | No |
| 131 | Tbrg4 | 7980 | -0.086 | 0.0814 | No |
| 132 | Pold2 | 8010 | -0.090 | 0.0809 | No |
| 133 | Hells | 8083 | -0.095 | 0.0769 | No |
| 134 | Brca2 | 8210 | -0.104 | 0.0687 | No |
| 135 | Xpo1 | 8234 | -0.105 | 0.0690 | No |
| 136 | Ccp110 | 8240 | -0.106 | 0.0708 | No |
| 137 | Lsm8 | 8361 | -0.115 | 0.0633 | No |
| 138 | Dck | 8476 | -0.123 | 0.0565 | No |
| 139 | Ppm1d | 8499 | -0.126 | 0.0573 | No |
| 140 | Jpt1 | 8500 | -0.126 | 0.0598 | No |
| 141 | Luc7l3 | 8511 | -0.127 | 0.0616 | No |
| 142 | Rfc2 | 8549 | -0.130 | 0.0613 | No |
| 143 | Tipin | 8599 | -0.132 | 0.0600 | No |
| 144 | Lmnb1 | 8740 | -0.142 | 0.0514 | No |
| 145 | Mybl2 | 9107 | -0.171 | 0.0249 | No |
| 146 | Tmpo | 9158 | -0.176 | 0.0244 | No |
| 147 | Pan2 | 9172 | -0.177 | 0.0270 | No |
| 148 | Bard1 | 9212 | -0.180 | 0.0275 | No |
| 149 | Ranbp1 | 9293 | -0.188 | 0.0248 | No |
| 150 | Aurka | 9338 | -0.189 | 0.0250 | No |
| 151 | Psip1 | 9404 | -0.195 | 0.0237 | No |
| 152 | Orc2 | 9449 | -0.199 | 0.0242 | No |
| 153 | Ubr7 | 9482 | -0.201 | 0.0257 | No |
| 154 | Ppp1r8 | 9645 | -0.213 | 0.0168 | No |
| 155 | Anp32e | 9866 | -0.233 | 0.0035 | No |
| 156 | Nup205 | 9926 | -0.239 | 0.0036 | No |
| 157 | Snrpb | 10139 | -0.259 | -0.0085 | No |
| 158 | Ezh2 | 10181 | -0.262 | -0.0064 | No |
| 159 | Eif2s1 | 10352 | -0.279 | -0.0146 | No |
| 160 | Lyar | 10421 | -0.285 | -0.0144 | No |
| 161 | Pole4 | 10450 | -0.287 | -0.0107 | No |
| 162 | Cdc25b | 10553 | -0.298 | -0.0130 | No |
| 163 | Nudt21 | 10956 | -0.343 | -0.0389 | No |
| 164 | Nme1 | 11014 | -0.352 | -0.0364 | No |
| 165 | Pold3 | 11127 | -0.364 | -0.0381 | No |
| 166 | Prdx4 | 11156 | -0.368 | -0.0328 | No |
| 167 | Nup153 | 11221 | -0.377 | -0.0303 | No |
| 168 | Asf1a | 11414 | -0.408 | -0.0377 | No |
| 169 | Phf5a | 11510 | -0.425 | -0.0367 | No |
| 170 | Dscc1 | 11534 | -0.429 | -0.0298 | No |
| 171 | Wdr90 | 11618 | -0.447 | -0.0274 | No |
| 172 | Dctpp1 | 11683 | -0.460 | -0.0232 | No |
| 173 | Pold1 | 11757 | -0.476 | -0.0194 | No |
| 174 | Cnot9 | 11852 | -0.496 | -0.0169 | No |
| 175 | Ccne1 | 11862 | -0.498 | -0.0074 | No |
| 176 | Brca1 | 11935 | -0.521 | -0.0026 | No |
| 177 | Smc6 | 11963 | -0.532 | 0.0062 | No |
| 178 | H2ax | 12003 | -0.544 | 0.0141 | No |
| 179 | Cdk4 | 12274 | -0.745 | 0.0073 | No |

