| Dataset | HSC.HSC_Pheno.cls#Group1_versus_Group3.HSC_Pheno.cls#Group1_versus_Group3_repos |
| Phenotype | HSC_Pheno.cls#Group1_versus_Group3_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_E2F_TARGETS |
| Enrichment Score (ES) | -0.31202078 |
| Normalized Enrichment Score (NES) | -1.0387216 |
| Nominal p-value | 0.42239687 |
| FDR q-value | 0.6401418 |
| FWER p-Value | 0.996 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Rad1 | 197 | 0.831 | 0.0011 | No |
| 2 | Pms2 | 238 | 0.784 | 0.0142 | No |
| 3 | Ubr7 | 362 | 0.713 | 0.0189 | No |
| 4 | Hnrnpd | 368 | 0.708 | 0.0333 | No |
| 5 | Tra2b | 394 | 0.696 | 0.0457 | No |
| 6 | Nudt21 | 496 | 0.634 | 0.0506 | No |
| 7 | Spc25 | 605 | 0.592 | 0.0541 | No |
| 8 | Zw10 | 628 | 0.584 | 0.0644 | No |
| 9 | Gins3 | 732 | 0.559 | 0.0676 | No |
| 10 | Orc2 | 884 | 0.519 | 0.0660 | No |
| 11 | Xrcc6 | 958 | 0.501 | 0.0705 | No |
| 12 | Smc1a | 1228 | 0.444 | 0.0576 | No |
| 13 | Ing3 | 1589 | 0.396 | 0.0363 | No |
| 14 | Wdr90 | 1704 | 0.381 | 0.0349 | No |
| 15 | Ssrp1 | 1807 | 0.370 | 0.0342 | No |
| 16 | Smc6 | 1896 | 0.356 | 0.0344 | No |
| 17 | Cdc25b | 1997 | 0.342 | 0.0333 | No |
| 18 | E2f8 | 2169 | 0.320 | 0.0260 | No |
| 19 | Ddx39a | 2267 | 0.310 | 0.0245 | No |
| 20 | Ube2s | 2492 | 0.281 | 0.0119 | No |
| 21 | Ube2t | 2706 | 0.262 | -0.0001 | No |
| 22 | Rad21 | 2747 | 0.259 | 0.0020 | No |
| 23 | Xpo1 | 2790 | 0.255 | 0.0039 | No |
| 24 | Ppm1d | 2867 | 0.247 | 0.0028 | No |
| 25 | Rpa3 | 3018 | 0.232 | -0.0047 | No |
| 26 | Spag5 | 3055 | 0.229 | -0.0029 | No |
| 27 | Psmc3ip | 3130 | 0.224 | -0.0043 | No |
| 28 | Mlh1 | 3182 | 0.220 | -0.0039 | No |
| 29 | Rrm2 | 3248 | 0.215 | -0.0047 | No |
| 30 | Ranbp1 | 3376 | 0.205 | -0.0109 | No |
| 31 | Ncapd2 | 3426 | 0.203 | -0.0107 | No |
| 32 | Dlgap5 | 3437 | 0.202 | -0.0073 | No |
| 33 | Kif4 | 3481 | 0.199 | -0.0067 | No |
| 34 | Nbn | 3493 | 0.197 | -0.0035 | No |
| 35 | Cdkn1b | 3503 | 0.197 | -0.0002 | No |
| 36 | Dek | 3586 | 0.190 | -0.0029 | No |
| 37 | Gspt1 | 3597 | 0.189 | 0.0002 | No |
| 38 | Rad50 | 3789 | 0.173 | -0.0119 | No |
| 39 | Racgap1 | 4124 | 0.144 | -0.0363 | No |
| 40 | Mthfd2 | 4161 | 0.141 | -0.0363 | No |
| 41 | Lbr | 4407 | 0.124 | -0.0539 | No |
| 42 | Ran | 4410 | 0.123 | -0.0514 | No |
| 43 | Srsf2 | 4411 | 0.123 | -0.0489 | No |
| 44 | Stag1 | 4583 | 0.108 | -0.0607 | No |
| 45 | Prps1 | 4641 | 0.104 | -0.0632 | No |
| 46 | Pds5b | 4685 | 0.100 | -0.0646 | No |
| 47 | Cse1l | 4688 | 0.099 | -0.0627 | No |
| 48 | Pttg1 | 4705 | 0.098 | -0.0620 | No |
| 49 | Donson | 4712 | 0.098 | -0.0605 | No |
| 50 | Shmt1 | 4860 | 0.087 | -0.0707 | No |
| 51 | Mcm7 | 4993 | 0.078 | -0.0799 | No |
| 52 | Orc6 | 5026 | 0.075 | -0.0810 | No |
| 53 | Pa2g4 | 5033 | 0.074 | -0.0799 | No |
| 54 | Slbp | 5194 | 0.062 | -0.0918 | No |
| 55 | Nup107 | 5236 | 0.059 | -0.0939 | No |
| 56 | Pola2 | 5255 | 0.058 | -0.0942 | No |
| 57 | Smc4 | 5264 | 0.057 | -0.0936 | No |
| 58 | Brca2 | 5308 | 0.055 | -0.0960 | No |
| 59 | Rpa1 | 5495 | 0.041 | -0.1104 | No |
| 60 | Dclre1b | 5497 | 0.041 | -0.1097 | No |
| 61 | Rfc3 | 5532 | 0.039 | -0.1116 | No |
| 62 | Mcm2 | 5546 | 0.038 | -0.1119 | No |
| 63 | Tacc3 | 5564 | 0.037 | -0.1125 | No |
| 64 | Rad51ap1 | 5632 | 0.032 | -0.1174 | No |
| 65 | Dctpp1 | 5656 | 0.030 | -0.1186 | No |
| 66 | Bard1 | 5703 | 0.027 | -0.1218 | No |
| 67 | Mybl2 | 5813 | 0.020 | -0.1304 | No |
| 68 | Pcna | 6061 | 0.002 | -0.1506 | No |
| 69 | Ezh2 | 6161 | -0.001 | -0.1587 | No |
| 70 | Rfc2 | 6236 | -0.007 | -0.1646 | No |
| 71 | Tubb5 | 6261 | -0.008 | -0.1664 | No |
| 72 | Cdca8 | 6363 | -0.015 | -0.1744 | No |
| 73 | Eed | 6424 | -0.020 | -0.1789 | No |
| 74 | Ppp1r8 | 6455 | -0.022 | -0.1809 | No |
| 75 | Cenpe | 6567 | -0.030 | -0.1894 | No |
| 76 | Ipo7 | 6579 | -0.030 | -0.1897 | No |
| 77 | Cit | 6597 | -0.032 | -0.1904 | No |
| 78 | Cdc20 | 6668 | -0.037 | -0.1954 | No |
| 79 | Plk4 | 6800 | -0.045 | -0.2052 | No |
| 80 | Mki67 | 6863 | -0.050 | -0.2092 | No |
| 81 | Top2a | 7036 | -0.061 | -0.2221 | No |
| 82 | Chek1 | 7151 | -0.068 | -0.2300 | No |
| 83 | Tk1 | 7155 | -0.069 | -0.2288 | No |
| 84 | Hmgb2 | 7430 | -0.085 | -0.2496 | No |
| 85 | Cks2 | 7516 | -0.091 | -0.2546 | No |
| 86 | Bub1b | 7577 | -0.095 | -0.2576 | No |
| 87 | Cdc25a | 7580 | -0.096 | -0.2557 | No |
| 88 | H2az1 | 7704 | -0.104 | -0.2637 | No |
| 89 | Lig1 | 7891 | -0.117 | -0.2765 | No |
| 90 | Pole | 8079 | -0.129 | -0.2892 | No |
| 91 | Smc3 | 8208 | -0.138 | -0.2968 | No |
| 92 | Nolc1 | 8263 | -0.143 | -0.2982 | No |
| 93 | Trip13 | 8316 | -0.146 | -0.2995 | No |
| 94 | Pold2 | 8355 | -0.149 | -0.2995 | No |
| 95 | Pnn | 8396 | -0.151 | -0.2996 | No |
| 96 | Ak2 | 8494 | -0.157 | -0.3043 | No |
| 97 | Tubg1 | 8525 | -0.159 | -0.3035 | No |
| 98 | Luc7l3 | 8541 | -0.160 | -0.3014 | No |
| 99 | Dut | 8555 | -0.161 | -0.2991 | No |
| 100 | Mre11a | 8616 | -0.165 | -0.3006 | No |
| 101 | Prim2 | 8693 | -0.172 | -0.3032 | No |
| 102 | Hells | 8743 | -0.175 | -0.3036 | No |
| 103 | Rpa2 | 8780 | -0.178 | -0.3029 | No |
| 104 | Hmmr | 8788 | -0.179 | -0.2997 | No |
| 105 | Suv39h1 | 8835 | -0.183 | -0.2997 | No |
| 106 | Nop56 | 8876 | -0.186 | -0.2991 | No |
| 107 | Cdkn2c | 8931 | -0.191 | -0.2995 | No |
| 108 | Pole4 | 8973 | -0.193 | -0.2989 | No |
| 109 | Rnaseh2a | 9029 | -0.197 | -0.2993 | No |
| 110 | Tipin | 9052 | -0.199 | -0.2969 | No |
| 111 | Nap1l1 | 9224 | -0.211 | -0.3066 | No |
| 112 | Hmgb3 | 9264 | -0.215 | -0.3053 | No |
| 113 | Prkdc | 9345 | -0.222 | -0.3073 | No |
| 114 | Dck | 9404 | -0.227 | -0.3073 | Yes |
| 115 | Chek2 | 9425 | -0.229 | -0.3042 | Yes |
| 116 | Tbrg4 | 9492 | -0.235 | -0.3047 | Yes |
| 117 | Msh2 | 9531 | -0.237 | -0.3029 | Yes |
| 118 | Ctcf | 9532 | -0.237 | -0.2980 | Yes |
| 119 | Jpt1 | 9533 | -0.237 | -0.2930 | Yes |
| 120 | Mcm4 | 9543 | -0.238 | -0.2888 | Yes |
| 121 | H2ax | 9561 | -0.240 | -0.2852 | Yes |
| 122 | Syncrip | 9606 | -0.244 | -0.2837 | Yes |
| 123 | Srsf1 | 9746 | -0.256 | -0.2898 | Yes |
| 124 | Snrpb | 9774 | -0.259 | -0.2866 | Yes |
| 125 | Tmpo | 9781 | -0.259 | -0.2817 | Yes |
| 126 | Nasp | 9827 | -0.262 | -0.2800 | Yes |
| 127 | Anp32e | 9882 | -0.267 | -0.2789 | Yes |
| 128 | Exosc8 | 9908 | -0.269 | -0.2753 | Yes |
| 129 | Depdc1a | 9952 | -0.274 | -0.2731 | Yes |
| 130 | Usp1 | 9964 | -0.274 | -0.2683 | Yes |
| 131 | Pan2 | 10005 | -0.278 | -0.2658 | Yes |
| 132 | Cnot9 | 10067 | -0.284 | -0.2649 | Yes |
| 133 | Myc | 10070 | -0.284 | -0.2591 | Yes |
| 134 | Atad2 | 10147 | -0.290 | -0.2593 | Yes |
| 135 | Mcm6 | 10218 | -0.297 | -0.2589 | Yes |
| 136 | Aurka | 10290 | -0.304 | -0.2584 | Yes |
| 137 | Ccnb2 | 10330 | -0.307 | -0.2552 | Yes |
| 138 | Cdk1 | 10367 | -0.310 | -0.2517 | Yes |
| 139 | Pold3 | 10382 | -0.311 | -0.2464 | Yes |
| 140 | Stmn1 | 10394 | -0.312 | -0.2408 | Yes |
| 141 | Ilf3 | 10436 | -0.317 | -0.2375 | Yes |
| 142 | Rfc1 | 10515 | -0.327 | -0.2371 | Yes |
| 143 | Dnmt1 | 10550 | -0.330 | -0.2331 | Yes |
| 144 | Tfrc | 10572 | -0.333 | -0.2278 | Yes |
| 145 | Phf5a | 10582 | -0.334 | -0.2216 | Yes |
| 146 | Nup153 | 10630 | -0.339 | -0.2184 | Yes |
| 147 | Ccp110 | 10849 | -0.364 | -0.2287 | Yes |
| 148 | Diaph3 | 10944 | -0.378 | -0.2286 | Yes |
| 149 | Pold1 | 10975 | -0.384 | -0.2230 | Yes |
| 150 | Mms22l | 11012 | -0.389 | -0.2179 | Yes |
| 151 | Birc5 | 11014 | -0.389 | -0.2099 | Yes |
| 152 | Mad2l1 | 11092 | -0.401 | -0.2079 | Yes |
| 153 | Mcm5 | 11110 | -0.403 | -0.2009 | Yes |
| 154 | Gins4 | 11129 | -0.406 | -0.1939 | Yes |
| 155 | Cbx5 | 11134 | -0.407 | -0.1857 | Yes |
| 156 | Asf1a | 11185 | -0.415 | -0.1812 | Yes |
| 157 | Ccne1 | 11189 | -0.416 | -0.1728 | Yes |
| 158 | Wee1 | 11263 | -0.427 | -0.1699 | Yes |
| 159 | Kif18b | 11407 | -0.452 | -0.1722 | Yes |
| 160 | Hus1 | 11421 | -0.455 | -0.1638 | Yes |
| 161 | Paics | 11435 | -0.458 | -0.1553 | Yes |
| 162 | Rbbp7 | 11442 | -0.459 | -0.1463 | Yes |
| 163 | Gins1 | 11536 | -0.475 | -0.1440 | Yes |
| 164 | Lmnb1 | 11561 | -0.481 | -0.1360 | Yes |
| 165 | Lyar | 11588 | -0.486 | -0.1280 | Yes |
| 166 | Lsm8 | 11633 | -0.493 | -0.1213 | Yes |
| 167 | Eif2s1 | 11640 | -0.496 | -0.1115 | Yes |
| 168 | Cenpm | 11759 | -0.521 | -0.1103 | Yes |
| 169 | Psip1 | 11792 | -0.529 | -0.1020 | Yes |
| 170 | Brca1 | 11891 | -0.554 | -0.0985 | Yes |
| 171 | Prdx4 | 11937 | -0.571 | -0.0903 | Yes |
| 172 | Timeless | 11945 | -0.575 | -0.0789 | Yes |
| 173 | Trp53 | 12088 | -0.635 | -0.0773 | Yes |
| 174 | Brms1l | 12124 | -0.659 | -0.0665 | Yes |
| 175 | Nup205 | 12168 | -0.682 | -0.0558 | Yes |
| 176 | Dscc1 | 12281 | -0.805 | -0.0482 | Yes |
| 177 | Nme1 | 12290 | -0.816 | -0.0319 | Yes |
| 178 | Mcm3 | 12319 | -0.885 | -0.0157 | Yes |
| 179 | Cdk4 | 12328 | -0.926 | 0.0029 | Yes |

