| Dataset | GMP.GMP.neu_Pheno.cls #Group6_versus_Group8.GMP.neu_Pheno.cls #Group6_versus_Group8_repos |
| Phenotype | GMP.neu_Pheno.cls#Group6_versus_Group8_repos |
| Upregulated in class | 5 |
| GeneSet | HALLMARK_E2F_TARGETS |
| Enrichment Score (ES) | -0.361812 |
| Normalized Enrichment Score (NES) | -1.5680392 |
| Nominal p-value | 0.085487075 |
| FDR q-value | 0.088287994 |
| FWER p-Value | 0.258 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Plk1 | 420 | 0.689 | -0.0060 | No |
| 2 | Cks2 | 1020 | 0.543 | -0.0243 | No |
| 3 | Bub1b | 1058 | 0.538 | -0.0143 | No |
| 4 | Ube2s | 1220 | 0.514 | -0.0111 | No |
| 5 | Spag5 | 1221 | 0.514 | 0.0002 | No |
| 6 | Cit | 1547 | 0.474 | -0.0058 | No |
| 7 | Depdc1a | 1901 | 0.436 | -0.0140 | No |
| 8 | Tbrg4 | 1986 | 0.426 | -0.0089 | No |
| 9 | Mybl2 | 2134 | 0.409 | -0.0073 | No |
| 10 | Aurkb | 2232 | 0.396 | -0.0035 | No |
| 11 | Rad51c | 2250 | 0.394 | 0.0044 | No |
| 12 | Dck | 2452 | 0.379 | 0.0025 | No |
| 13 | Mki67 | 2600 | 0.369 | 0.0032 | No |
| 14 | Espl1 | 3120 | 0.338 | -0.0155 | No |
| 15 | Aurka | 3547 | 0.309 | -0.0302 | No |
| 16 | Prim2 | 3885 | 0.282 | -0.0410 | No |
| 17 | Tacc3 | 4242 | 0.259 | -0.0532 | No |
| 18 | Hmga1b | 4468 | 0.244 | -0.0592 | No |
| 19 | Kif22 | 4560 | 0.240 | -0.0585 | No |
| 20 | Diaph3 | 4677 | 0.234 | -0.0592 | No |
| 21 | Cenpe | 4764 | 0.229 | -0.0585 | No |
| 22 | Cenpm | 4901 | 0.221 | -0.0605 | No |
| 23 | Pold1 | 4938 | 0.218 | -0.0575 | No |
| 24 | Tfrc | 4969 | 0.217 | -0.0543 | No |
| 25 | Slbp | 5099 | 0.209 | -0.0562 | No |
| 26 | Rad21 | 5140 | 0.206 | -0.0537 | No |
| 27 | Hmmr | 5813 | 0.181 | -0.0836 | No |
| 28 | Ppm1d | 6035 | 0.170 | -0.0910 | No |
| 29 | Kif18b | 6303 | 0.162 | -0.1009 | No |
| 30 | Stag1 | 6538 | 0.150 | -0.1094 | No |
| 31 | Chek2 | 6621 | 0.145 | -0.1104 | No |
| 32 | Mre11a | 6829 | 0.136 | -0.1178 | No |
| 33 | Plk4 | 6943 | 0.132 | -0.1206 | No |
| 34 | Tra2b | 7007 | 0.129 | -0.1210 | No |
| 35 | Mcm5 | 7052 | 0.127 | -0.1204 | No |
| 36 | Ilf3 | 7091 | 0.125 | -0.1196 | No |
| 37 | Cdc25a | 7167 | 0.121 | -0.1207 | No |
| 38 | Ccp110 | 7324 | 0.114 | -0.1260 | No |
| 39 | Mms22l | 7373 | 0.111 | -0.1260 | No |
| 40 | Tipin | 7603 | 0.101 | -0.1353 | No |
| 41 | Cdc25b | 7715 | 0.096 | -0.1388 | No |
| 42 | Pola2 | 7769 | 0.094 | -0.1394 | No |
| 43 | Gins4 | 7795 | 0.093 | -0.1386 | No |
| 44 | Nup205 | 7817 | 0.092 | -0.1377 | No |
| 45 | Xpo1 | 7849 | 0.090 | -0.1373 | No |
| 46 | Kif4 | 7932 | 0.087 | -0.1395 | No |
| 47 | Bard1 | 7981 | 0.086 | -0.1400 | No |
| 48 | Pan2 | 8263 | 0.074 | -0.1525 | No |
| 49 | Zw10 | 8400 | 0.068 | -0.1579 | No |
| 50 | Lmnb1 | 8530 | 0.063 | -0.1630 | No |
| 51 | Racgap1 | 8638 | 0.059 | -0.1671 | No |
| 52 | Cbx5 | 8672 | 0.058 | -0.1675 | No |
| 53 | Pds5b | 8891 | 0.049 | -0.1774 | No |
| 54 | Smc4 | 8899 | 0.049 | -0.1767 | No |
| 55 | Cdk1 | 8908 | 0.049 | -0.1760 | No |
| 56 | Cnot9 | 9259 | 0.034 | -0.1929 | No |
| 57 | Exosc8 | 9336 | 0.031 | -0.1961 | No |
| 58 | Cdca8 | 9373 | 0.029 | -0.1972 | No |
| 59 | Dnmt1 | 9498 | 0.025 | -0.2029 | No |
| 60 | Gins3 | 9578 | 0.021 | -0.2065 | No |
| 61 | Orc2 | 9656 | 0.018 | -0.2099 | No |
| 62 | Suv39h1 | 9776 | 0.013 | -0.2157 | No |
| 63 | Lsm8 | 9897 | 0.007 | -0.2215 | No |
| 64 | Pnn | 9910 | 0.007 | -0.2220 | No |
| 65 | Kif2c | 10385 | -0.003 | -0.2458 | No |
| 66 | Smc1a | 10596 | -0.011 | -0.2562 | No |
| 67 | Tk1 | 10675 | -0.013 | -0.2598 | No |
| 68 | Cdkn3 | 10677 | -0.013 | -0.2596 | No |
| 69 | Nup153 | 10962 | -0.023 | -0.2734 | No |
| 70 | Pold2 | 11165 | -0.032 | -0.2829 | No |
| 71 | Mxd3 | 11183 | -0.032 | -0.2830 | No |
| 72 | Mad2l1 | 11294 | -0.037 | -0.2878 | No |
| 73 | E2f8 | 11305 | -0.037 | -0.2875 | No |
| 74 | Pole | 11306 | -0.037 | -0.2867 | No |
| 75 | Shmt1 | 11389 | -0.040 | -0.2899 | No |
| 76 | Dlgap5 | 11419 | -0.042 | -0.2904 | No |
| 77 | Cse1l | 11475 | -0.044 | -0.2923 | No |
| 78 | Ak2 | 11727 | -0.054 | -0.3037 | No |
| 79 | Trip13 | 11789 | -0.057 | -0.3055 | No |
| 80 | Ezh2 | 11815 | -0.058 | -0.3055 | No |
| 81 | Ipo7 | 11859 | -0.060 | -0.3064 | No |
| 82 | Nup107 | 11863 | -0.060 | -0.3052 | No |
| 83 | Spc25 | 11909 | -0.062 | -0.3061 | No |
| 84 | Chek1 | 11954 | -0.064 | -0.3069 | No |
| 85 | Srsf2 | 12046 | -0.068 | -0.3100 | No |
| 86 | Trp53 | 12075 | -0.069 | -0.3099 | No |
| 87 | Brms1l | 12173 | -0.074 | -0.3131 | No |
| 88 | Atad2 | 12198 | -0.075 | -0.3127 | No |
| 89 | Birc5 | 12235 | -0.077 | -0.3128 | No |
| 90 | Brca2 | 12243 | -0.077 | -0.3115 | No |
| 91 | Rad50 | 12294 | -0.079 | -0.3123 | No |
| 92 | Ncapd2 | 12406 | -0.084 | -0.3160 | No |
| 93 | Hmgb3 | 12453 | -0.086 | -0.3164 | No |
| 94 | Prkdc | 12601 | -0.093 | -0.3218 | No |
| 95 | Pole4 | 12698 | -0.097 | -0.3245 | No |
| 96 | Lbr | 12774 | -0.101 | -0.3261 | No |
| 97 | Rpa2 | 12890 | -0.105 | -0.3296 | No |
| 98 | Dscc1 | 12956 | -0.107 | -0.3305 | No |
| 99 | Pms2 | 13191 | -0.117 | -0.3397 | No |
| 100 | Brca1 | 13260 | -0.120 | -0.3405 | No |
| 101 | Jpt1 | 13284 | -0.121 | -0.3390 | No |
| 102 | Spc24 | 13350 | -0.123 | -0.3396 | No |
| 103 | Eif2s1 | 13364 | -0.124 | -0.3375 | No |
| 104 | Top2a | 13549 | -0.132 | -0.3439 | No |
| 105 | Rad51ap1 | 13591 | -0.134 | -0.3430 | No |
| 106 | Rrm2 | 13677 | -0.138 | -0.3442 | No |
| 107 | Wee1 | 13685 | -0.138 | -0.3415 | No |
| 108 | Tmpo | 13764 | -0.141 | -0.3424 | No |
| 109 | Prdx4 | 13946 | -0.149 | -0.3482 | No |
| 110 | Mlh1 | 13975 | -0.150 | -0.3463 | No |
| 111 | H2az1 | 14000 | -0.151 | -0.3442 | No |
| 112 | Tcf19 | 14026 | -0.152 | -0.3421 | No |
| 113 | Ing3 | 14113 | -0.156 | -0.3430 | No |
| 114 | Mcm6 | 14130 | -0.157 | -0.3404 | No |
| 115 | Pold3 | 14192 | -0.159 | -0.3400 | No |
| 116 | Ubr7 | 14220 | -0.161 | -0.3378 | No |
| 117 | Nasp | 14380 | -0.167 | -0.3421 | No |
| 118 | Nudt21 | 14516 | -0.174 | -0.3451 | No |
| 119 | Hells | 14577 | -0.177 | -0.3443 | No |
| 120 | Tubg1 | 14580 | -0.177 | -0.3405 | No |
| 121 | Dctpp1 | 14716 | -0.183 | -0.3433 | No |
| 122 | Usp1 | 15085 | -0.201 | -0.3574 | Yes |
| 123 | Wdr90 | 15091 | -0.202 | -0.3532 | Yes |
| 124 | Msh2 | 15134 | -0.203 | -0.3508 | Yes |
| 125 | Melk | 15192 | -0.206 | -0.3492 | Yes |
| 126 | Nop56 | 15210 | -0.206 | -0.3455 | Yes |
| 127 | Ctcf | 15257 | -0.209 | -0.3432 | Yes |
| 128 | Orc6 | 15269 | -0.209 | -0.3392 | Yes |
| 129 | Eed | 15320 | -0.212 | -0.3370 | Yes |
| 130 | Lig1 | 15433 | -0.217 | -0.3379 | Yes |
| 131 | Dut | 15477 | -0.220 | -0.3352 | Yes |
| 132 | Gspt1 | 15575 | -0.224 | -0.3352 | Yes |
| 133 | Luc7l3 | 15653 | -0.228 | -0.3341 | Yes |
| 134 | Dclre1b | 15822 | -0.237 | -0.3373 | Yes |
| 135 | Pop7 | 15876 | -0.240 | -0.3347 | Yes |
| 136 | Hnrnpd | 15972 | -0.244 | -0.3341 | Yes |
| 137 | Cdkn1b | 16019 | -0.247 | -0.3310 | Yes |
| 138 | Ube2t | 16075 | -0.251 | -0.3283 | Yes |
| 139 | Cdkn2c | 16144 | -0.254 | -0.3261 | Yes |
| 140 | Rfc1 | 16178 | -0.256 | -0.3222 | Yes |
| 141 | Mcm7 | 16224 | -0.259 | -0.3187 | Yes |
| 142 | Anp32e | 16478 | -0.271 | -0.3255 | Yes |
| 143 | Nbn | 16588 | -0.276 | -0.3250 | Yes |
| 144 | Ccne1 | 16670 | -0.280 | -0.3229 | Yes |
| 145 | Ccnb2 | 16779 | -0.289 | -0.3220 | Yes |
| 146 | Stmn1 | 16851 | -0.294 | -0.3191 | Yes |
| 147 | Timeless | 16856 | -0.294 | -0.3128 | Yes |
| 148 | Cdk4 | 16857 | -0.294 | -0.3064 | Yes |
| 149 | Srsf1 | 16875 | -0.295 | -0.3008 | Yes |
| 150 | Rfc2 | 16929 | -0.299 | -0.2969 | Yes |
| 151 | Mcm2 | 16992 | -0.302 | -0.2933 | Yes |
| 152 | Pa2g4 | 17007 | -0.303 | -0.2874 | Yes |
| 153 | Cdkn1a | 17015 | -0.304 | -0.2811 | Yes |
| 154 | Ppp1r8 | 17043 | -0.306 | -0.2757 | Yes |
| 155 | Asf1b | 17070 | -0.308 | -0.2702 | Yes |
| 156 | Smc6 | 17072 | -0.308 | -0.2635 | Yes |
| 157 | Rbbp7 | 17142 | -0.313 | -0.2601 | Yes |
| 158 | Rpa1 | 17269 | -0.321 | -0.2594 | Yes |
| 159 | Ssrp1 | 17297 | -0.322 | -0.2537 | Yes |
| 160 | Cks1b | 17339 | -0.325 | -0.2486 | Yes |
| 161 | Psip1 | 17366 | -0.326 | -0.2427 | Yes |
| 162 | Gins1 | 17381 | -0.328 | -0.2363 | Yes |
| 163 | Prps1 | 17594 | -0.340 | -0.2395 | Yes |
| 164 | Rnaseh2a | 17641 | -0.343 | -0.2342 | Yes |
| 165 | Hus1 | 17657 | -0.344 | -0.2274 | Yes |
| 166 | Smc3 | 17660 | -0.344 | -0.2200 | Yes |
| 167 | Xrcc6 | 17673 | -0.345 | -0.2130 | Yes |
| 168 | Mcm4 | 17703 | -0.348 | -0.2068 | Yes |
| 169 | Ddx39a | 17715 | -0.349 | -0.1996 | Yes |
| 170 | Snrpb | 17762 | -0.353 | -0.1942 | Yes |
| 171 | Pttg1 | 17799 | -0.356 | -0.1882 | Yes |
| 172 | Ran | 17849 | -0.360 | -0.1827 | Yes |
| 173 | Syncrip | 18102 | -0.382 | -0.1870 | Yes |
| 174 | Cdc20 | 18157 | -0.387 | -0.1813 | Yes |
| 175 | Dek | 18165 | -0.387 | -0.1731 | Yes |
| 176 | Donson | 18232 | -0.393 | -0.1678 | Yes |
| 177 | Asf1a | 18351 | -0.404 | -0.1648 | Yes |
| 178 | Phf5a | 18383 | -0.407 | -0.1575 | Yes |
| 179 | Lyar | 18444 | -0.413 | -0.1514 | Yes |
| 180 | Psmc3ip | 18460 | -0.415 | -0.1430 | Yes |
| 181 | Pcna | 18467 | -0.415 | -0.1342 | Yes |
| 182 | Nme1 | 18513 | -0.420 | -0.1273 | Yes |
| 183 | Myc | 18603 | -0.431 | -0.1223 | Yes |
| 184 | Mcm3 | 18681 | -0.440 | -0.1165 | Yes |
| 185 | Ranbp1 | 18921 | -0.473 | -0.1181 | Yes |
| 186 | Rad1 | 19127 | -0.508 | -0.1173 | Yes |
| 187 | Hmgb2 | 19298 | -0.543 | -0.1139 | Yes |
| 188 | Paics | 19525 | -0.606 | -0.1120 | Yes |
| 189 | Mthfd2 | 19559 | -0.618 | -0.1001 | Yes |
| 190 | Nap1l1 | 19584 | -0.628 | -0.0875 | Yes |
| 191 | H2ax | 19618 | -0.645 | -0.0750 | Yes |
| 192 | Nolc1 | 19647 | -0.653 | -0.0620 | Yes |
| 193 | Rfc3 | 19649 | -0.655 | -0.0477 | Yes |
| 194 | Cdca3 | 19699 | -0.675 | -0.0353 | Yes |
| 195 | Tubb5 | 19705 | -0.680 | -0.0206 | Yes |
| 196 | Ung | 19892 | -0.795 | -0.0125 | Yes |
| 197 | Rpa3 | 19956 | -0.873 | 0.0035 | Yes |

