| Dataset | GMP.GMP.neu_Pheno.cls #Group2_versus_Group4.GMP.neu_Pheno.cls #Group2_versus_Group4_repos |
| Phenotype | GMP.neu_Pheno.cls#Group2_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_P53_PATHWAY |
| Enrichment Score (ES) | -0.22925746 |
| Normalized Enrichment Score (NES) | -0.9631529 |
| Nominal p-value | 0.48023716 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.989 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Ccp110 | 125 | 0.811 | 0.0104 | No |
| 2 | Tchh | 171 | 0.765 | 0.0239 | No |
| 3 | Ctsd | 204 | 0.737 | 0.0376 | No |
| 4 | Stom | 217 | 0.727 | 0.0520 | No |
| 5 | H2ac25 | 455 | 0.628 | 0.0530 | No |
| 6 | Klf4 | 460 | 0.625 | 0.0657 | No |
| 7 | App | 583 | 0.597 | 0.0718 | No |
| 8 | H1f2 | 648 | 0.576 | 0.0805 | No |
| 9 | Ralgds | 875 | 0.532 | 0.0801 | No |
| 10 | Rhbdf2 | 1079 | 0.498 | 0.0801 | No |
| 11 | Fos | 1092 | 0.496 | 0.0898 | No |
| 12 | Hras | 1426 | 0.454 | 0.0824 | No |
| 13 | Sdc1 | 1579 | 0.438 | 0.0837 | No |
| 14 | Ada | 1773 | 0.421 | 0.0827 | No |
| 15 | Tpd52l1 | 1978 | 0.402 | 0.0807 | No |
| 16 | Alox8 | 2094 | 0.396 | 0.0831 | No |
| 17 | Cd82 | 2131 | 0.393 | 0.0894 | No |
| 18 | Ddit4 | 2179 | 0.389 | 0.0951 | No |
| 19 | Mdm2 | 2372 | 0.373 | 0.0931 | No |
| 20 | S100a4 | 2402 | 0.372 | 0.0993 | No |
| 21 | Vdr | 2624 | 0.354 | 0.0955 | No |
| 22 | Jag2 | 2956 | 0.334 | 0.0857 | No |
| 23 | Slc7a11 | 2986 | 0.331 | 0.0911 | No |
| 24 | Rps12 | 3045 | 0.326 | 0.0949 | No |
| 25 | Rgs16 | 3220 | 0.315 | 0.0926 | No |
| 26 | Hspa4l | 3239 | 0.315 | 0.0982 | No |
| 27 | Abcc5 | 3261 | 0.314 | 0.1036 | No |
| 28 | Btg2 | 3431 | 0.304 | 0.1014 | No |
| 29 | Zfp36l1 | 3432 | 0.304 | 0.1077 | No |
| 30 | Ifi30 | 3618 | 0.292 | 0.1044 | No |
| 31 | Foxo3 | 3855 | 0.280 | 0.0983 | No |
| 32 | Prmt2 | 3916 | 0.276 | 0.1009 | No |
| 33 | Jun | 4204 | 0.262 | 0.0919 | No |
| 34 | Eps8l2 | 4680 | 0.235 | 0.0728 | No |
| 35 | Nupr1 | 4682 | 0.235 | 0.0776 | No |
| 36 | Pcna | 4692 | 0.235 | 0.0820 | No |
| 37 | Ip6k2 | 4714 | 0.233 | 0.0857 | No |
| 38 | Ccnk | 4765 | 0.230 | 0.0880 | No |
| 39 | Aen | 4864 | 0.225 | 0.0877 | No |
| 40 | Rnf19b | 4927 | 0.220 | 0.0891 | No |
| 41 | Slc35d1 | 4991 | 0.218 | 0.0904 | No |
| 42 | Hbegf | 5027 | 0.216 | 0.0931 | No |
| 43 | Bak1 | 5173 | 0.209 | 0.0901 | No |
| 44 | Hexim1 | 5354 | 0.198 | 0.0851 | No |
| 45 | Rrp8 | 5455 | 0.194 | 0.0841 | No |
| 46 | Polh | 5459 | 0.193 | 0.0879 | No |
| 47 | Slc3a2 | 5464 | 0.193 | 0.0917 | No |
| 48 | Cyfip2 | 5534 | 0.189 | 0.0921 | No |
| 49 | Tgfa | 5678 | 0.187 | 0.0888 | No |
| 50 | Mknk2 | 5783 | 0.181 | 0.0873 | No |
| 51 | Elp1 | 5821 | 0.179 | 0.0891 | No |
| 52 | Ndrg1 | 5832 | 0.178 | 0.0923 | No |
| 53 | Rps27l | 5930 | 0.174 | 0.0910 | No |
| 54 | Sphk1 | 5972 | 0.173 | 0.0925 | No |
| 55 | Cdh13 | 5992 | 0.172 | 0.0951 | No |
| 56 | Klk8 | 6114 | 0.166 | 0.0925 | No |
| 57 | Triap1 | 6306 | 0.156 | 0.0861 | No |
| 58 | Ei24 | 6423 | 0.151 | 0.0833 | No |
| 59 | Retsat | 6448 | 0.150 | 0.0852 | No |
| 60 | Itgb4 | 6616 | 0.144 | 0.0798 | No |
| 61 | Pvt1 | 6722 | 0.138 | 0.0773 | No |
| 62 | Sec61a1 | 6763 | 0.136 | 0.0781 | No |
| 63 | Txnip | 6869 | 0.129 | 0.0755 | No |
| 64 | Def6 | 6874 | 0.129 | 0.0779 | No |
| 65 | Apaf1 | 7022 | 0.122 | 0.0730 | No |
| 66 | Mapkapk3 | 7052 | 0.121 | 0.0740 | No |
| 67 | Rap2b | 7430 | 0.105 | 0.0572 | No |
| 68 | Trib3 | 7474 | 0.104 | 0.0572 | No |
| 69 | Rab40c | 7492 | 0.103 | 0.0585 | No |
| 70 | Tprkb | 7501 | 0.103 | 0.0602 | No |
| 71 | Rchy1 | 7518 | 0.102 | 0.0615 | No |
| 72 | Tax1bp3 | 7575 | 0.099 | 0.0607 | No |
| 73 | Socs1 | 7605 | 0.098 | 0.0613 | No |
| 74 | Fdxr | 7626 | 0.097 | 0.0622 | No |
| 75 | Ccnd2 | 7869 | 0.089 | 0.0519 | No |
| 76 | Pmm1 | 7940 | 0.087 | 0.0502 | No |
| 77 | Sat1 | 7949 | 0.086 | 0.0515 | No |
| 78 | Ccng1 | 8061 | 0.081 | 0.0476 | No |
| 79 | Fas | 8151 | 0.077 | 0.0447 | No |
| 80 | Plk3 | 8210 | 0.074 | 0.0433 | No |
| 81 | Trafd1 | 8218 | 0.074 | 0.0445 | No |
| 82 | Prkab1 | 8377 | 0.066 | 0.0379 | No |
| 83 | Fuca1 | 8477 | 0.062 | 0.0342 | No |
| 84 | Rad9a | 8551 | 0.060 | 0.0317 | No |
| 85 | Abhd4 | 8561 | 0.059 | 0.0325 | No |
| 86 | S100a10 | 8783 | 0.049 | 0.0224 | No |
| 87 | Fbxw7 | 8802 | 0.049 | 0.0225 | No |
| 88 | Casp1 | 8945 | 0.042 | 0.0162 | No |
| 89 | Tap1 | 9210 | 0.031 | 0.0036 | No |
| 90 | Ercc5 | 9216 | 0.031 | 0.0039 | No |
| 91 | Plk2 | 9551 | 0.016 | -0.0126 | No |
| 92 | Cdkn2aip | 9606 | 0.013 | -0.0150 | No |
| 93 | Cebpa | 9642 | 0.011 | -0.0166 | No |
| 94 | Osgin1 | 9736 | 0.007 | -0.0211 | No |
| 95 | Dnttip2 | 9739 | 0.007 | -0.0211 | No |
| 96 | Irag2 | 9844 | 0.002 | -0.0263 | No |
| 97 | Rpl36 | 10198 | -0.011 | -0.0438 | No |
| 98 | Kif13b | 10234 | -0.012 | -0.0453 | No |
| 99 | Gadd45a | 10586 | -0.026 | -0.0625 | No |
| 100 | Nudt15 | 10643 | -0.029 | -0.0647 | No |
| 101 | Rb1 | 10656 | -0.030 | -0.0647 | No |
| 102 | Abat | 10660 | -0.030 | -0.0643 | No |
| 103 | Tm7sf3 | 10747 | -0.032 | -0.0679 | No |
| 104 | Hdac3 | 10758 | -0.033 | -0.0677 | No |
| 105 | Tspyl2 | 10928 | -0.041 | -0.0754 | No |
| 106 | Ninj1 | 10966 | -0.043 | -0.0764 | No |
| 107 | Sp1 | 11186 | -0.052 | -0.0864 | No |
| 108 | Hmox1 | 11210 | -0.053 | -0.0864 | No |
| 109 | Xpc | 11367 | -0.060 | -0.0931 | No |
| 110 | Notch1 | 11368 | -0.060 | -0.0918 | No |
| 111 | Fam162a | 11507 | -0.067 | -0.0974 | No |
| 112 | Ier5 | 11540 | -0.068 | -0.0976 | No |
| 113 | Plxnb2 | 11869 | -0.085 | -0.1124 | No |
| 114 | Cdk5r1 | 11978 | -0.089 | -0.1160 | No |
| 115 | Rxra | 12209 | -0.100 | -0.1255 | No |
| 116 | Hint1 | 12245 | -0.102 | -0.1252 | No |
| 117 | Wwp1 | 12269 | -0.103 | -0.1242 | No |
| 118 | Coq8a | 12472 | -0.110 | -0.1321 | No |
| 119 | Pom121 | 12620 | -0.115 | -0.1372 | No |
| 120 | Sfn | 12726 | -0.120 | -0.1400 | No |
| 121 | Ppp1r15a | 13832 | -0.173 | -0.1921 | No |
| 122 | Nol8 | 13898 | -0.176 | -0.1917 | No |
| 123 | Ak1 | 14219 | -0.191 | -0.2039 | No |
| 124 | St14 | 14324 | -0.196 | -0.2051 | No |
| 125 | Ankra2 | 14346 | -0.197 | -0.2021 | No |
| 126 | Dgka | 14359 | -0.198 | -0.1986 | No |
| 127 | Sesn1 | 14473 | -0.203 | -0.2001 | No |
| 128 | Ldhb | 14495 | -0.204 | -0.1970 | No |
| 129 | Vwa5a | 14653 | -0.212 | -0.2005 | No |
| 130 | Cdkn1a | 14725 | -0.216 | -0.1996 | No |
| 131 | Sertad3 | 14739 | -0.217 | -0.1958 | No |
| 132 | Rad51c | 14754 | -0.217 | -0.1920 | No |
| 133 | Mxd4 | 14765 | -0.218 | -0.1880 | No |
| 134 | Tgfb1 | 14901 | -0.224 | -0.1902 | No |
| 135 | Ppm1d | 14984 | -0.228 | -0.1896 | No |
| 136 | Cd81 | 15187 | -0.236 | -0.1949 | No |
| 137 | Ccnd3 | 15293 | -0.241 | -0.1953 | No |
| 138 | Zmat3 | 15330 | -0.243 | -0.1921 | No |
| 139 | Ddb2 | 15337 | -0.243 | -0.1874 | No |
| 140 | Pdgfa | 15481 | -0.250 | -0.1894 | No |
| 141 | Btg1 | 15763 | -0.266 | -0.1981 | No |
| 142 | Acvr1b | 15951 | -0.277 | -0.2018 | No |
| 143 | Perp | 16054 | -0.282 | -0.2011 | No |
| 144 | Slc19a2 | 16220 | -0.291 | -0.2034 | No |
| 145 | Ptpre | 16495 | -0.307 | -0.2109 | No |
| 146 | Rpl18 | 16645 | -0.315 | -0.2119 | No |
| 147 | Dram1 | 16749 | -0.322 | -0.2105 | No |
| 148 | Bax | 16829 | -0.326 | -0.2077 | No |
| 149 | Gm2a | 16887 | -0.329 | -0.2038 | No |
| 150 | Pidd1 | 17374 | -0.363 | -0.2208 | No |
| 151 | Blcap | 17543 | -0.377 | -0.2215 | Yes |
| 152 | Dcxr | 17612 | -0.383 | -0.2170 | Yes |
| 153 | Rack1 | 17664 | -0.387 | -0.2116 | Yes |
| 154 | Tob1 | 17693 | -0.390 | -0.2049 | Yes |
| 155 | Gls2 | 17705 | -0.392 | -0.1974 | Yes |
| 156 | Trp53 | 17850 | -0.406 | -0.1963 | Yes |
| 157 | Ctsf | 17918 | -0.410 | -0.1912 | Yes |
| 158 | Mxd1 | 17930 | -0.411 | -0.1833 | Yes |
| 159 | Irak1 | 18012 | -0.416 | -0.1788 | Yes |
| 160 | Cgrrf1 | 18106 | -0.425 | -0.1747 | Yes |
| 161 | Atf3 | 18173 | -0.432 | -0.1691 | Yes |
| 162 | H2aj | 18196 | -0.435 | -0.1612 | Yes |
| 163 | Tnfsf9 | 18251 | -0.440 | -0.1549 | Yes |
| 164 | Steap3 | 18365 | -0.452 | -0.1512 | Yes |
| 165 | Iscu | 18441 | -0.460 | -0.1455 | Yes |
| 166 | Rrad | 18465 | -0.463 | -0.1371 | Yes |
| 167 | Baiap2 | 18478 | -0.465 | -0.1281 | Yes |
| 168 | Zbtb16 | 18517 | -0.470 | -0.1204 | Yes |
| 169 | Pitpnc1 | 18522 | -0.470 | -0.1109 | Yes |
| 170 | Vamp8 | 18690 | -0.486 | -0.1093 | Yes |
| 171 | Ddit3 | 18932 | -0.518 | -0.1107 | Yes |
| 172 | Tcn2 | 18995 | -0.530 | -0.1029 | Yes |
| 173 | Traf4 | 19173 | -0.560 | -0.1003 | Yes |
| 174 | Procr | 19301 | -0.586 | -0.0946 | Yes |
| 175 | F2r | 19410 | -0.614 | -0.0873 | Yes |
| 176 | Tsc22d1 | 19446 | -0.623 | -0.0762 | Yes |
| 177 | Wrap73 | 19479 | -0.631 | -0.0648 | Yes |
| 178 | Csrnp2 | 19539 | -0.646 | -0.0545 | Yes |
| 179 | Ptpn14 | 19541 | -0.646 | -0.0412 | Yes |
| 180 | Ephx1 | 19567 | -0.656 | -0.0289 | Yes |
| 181 | Trp63 | 19832 | -0.780 | -0.0261 | Yes |
| 182 | Fgf13 | 19904 | -0.859 | -0.0120 | Yes |
| 183 | Ier3 | 19920 | -0.877 | 0.0053 | Yes |

