| Dataset | GMP.GMP.neu_Pheno.cls #Group2_versus_Group4.GMP.neu_Pheno.cls #Group2_versus_Group4_repos |
| Phenotype | GMP.neu_Pheno.cls#Group2_versus_Group4_repos |
| Upregulated in class | 1 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | 0.43782005 |
| Normalized Enrichment Score (NES) | 1.5555525 |
| Nominal p-value | 0.07505071 |
| FDR q-value | 0.13261212 |
| FWER p-Value | 0.273 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Cyp51 | 7 | 1.253 | 0.0220 | Yes |
| 2 | Insig1 | 83 | 0.857 | 0.0336 | Yes |
| 3 | Bhlhe40 | 112 | 0.820 | 0.0468 | Yes |
| 4 | Xbp1 | 152 | 0.781 | 0.0588 | Yes |
| 5 | Rpn1 | 183 | 0.752 | 0.0708 | Yes |
| 6 | Sqle | 198 | 0.741 | 0.0833 | Yes |
| 7 | Stard4 | 245 | 0.708 | 0.0936 | Yes |
| 8 | Gpi1 | 264 | 0.697 | 0.1052 | Yes |
| 9 | Psmc4 | 278 | 0.691 | 0.1169 | Yes |
| 10 | Hspa5 | 296 | 0.683 | 0.1282 | Yes |
| 11 | Aldoa | 334 | 0.666 | 0.1383 | Yes |
| 12 | Hsp90b1 | 402 | 0.642 | 0.1464 | Yes |
| 13 | Actr2 | 412 | 0.640 | 0.1574 | Yes |
| 14 | Canx | 452 | 0.629 | 0.1666 | Yes |
| 15 | Edem1 | 467 | 0.623 | 0.1771 | Yes |
| 16 | Hspa9 | 473 | 0.622 | 0.1880 | Yes |
| 17 | Ddx39a | 493 | 0.617 | 0.1980 | Yes |
| 18 | Hspd1 | 545 | 0.606 | 0.2063 | Yes |
| 19 | Serp1 | 598 | 0.591 | 0.2142 | Yes |
| 20 | Pnp | 615 | 0.585 | 0.2239 | Yes |
| 21 | Abcf2 | 624 | 0.582 | 0.2339 | Yes |
| 22 | Dhcr24 | 666 | 0.574 | 0.2421 | Yes |
| 23 | Acly | 673 | 0.573 | 0.2520 | Yes |
| 24 | Ung | 685 | 0.570 | 0.2617 | Yes |
| 25 | Gga2 | 756 | 0.556 | 0.2681 | Yes |
| 26 | Hmgcr | 890 | 0.530 | 0.2708 | Yes |
| 27 | Calr | 915 | 0.525 | 0.2790 | Yes |
| 28 | Idi1 | 925 | 0.523 | 0.2879 | Yes |
| 29 | Cth | 932 | 0.521 | 0.2969 | Yes |
| 30 | Atp2a2 | 966 | 0.517 | 0.3045 | Yes |
| 31 | Ssr1 | 1077 | 0.499 | 0.3079 | Yes |
| 32 | Pno1 | 1104 | 0.495 | 0.3154 | Yes |
| 33 | Fgl2 | 1189 | 0.484 | 0.3198 | Yes |
| 34 | Stip1 | 1227 | 0.479 | 0.3265 | Yes |
| 35 | Ldlr | 1297 | 0.468 | 0.3314 | Yes |
| 36 | Ero1a | 1498 | 0.447 | 0.3293 | Yes |
| 37 | Hspa4 | 1524 | 0.443 | 0.3360 | Yes |
| 38 | Etf1 | 1698 | 0.427 | 0.3349 | Yes |
| 39 | Rrp9 | 1777 | 0.421 | 0.3385 | Yes |
| 40 | Rab1a | 1823 | 0.416 | 0.3437 | Yes |
| 41 | Txnrd1 | 2123 | 0.394 | 0.3356 | Yes |
| 42 | Bub1 | 2124 | 0.394 | 0.3427 | Yes |
| 43 | Psme3 | 2125 | 0.394 | 0.3497 | Yes |
| 44 | P4ha1 | 2145 | 0.391 | 0.3558 | Yes |
| 45 | Ddit4 | 2179 | 0.389 | 0.3611 | Yes |
| 46 | Ccnf | 2218 | 0.385 | 0.3660 | Yes |
| 47 | Psmd14 | 2251 | 0.382 | 0.3713 | Yes |
| 48 | Plk1 | 2425 | 0.371 | 0.3692 | Yes |
| 49 | Ppia | 2532 | 0.362 | 0.3703 | Yes |
| 50 | Tm7sf2 | 2811 | 0.344 | 0.3624 | Yes |
| 51 | Cyb5b | 2824 | 0.343 | 0.3679 | Yes |
| 52 | Nufip1 | 2877 | 0.339 | 0.3714 | Yes |
| 53 | Actr3 | 2944 | 0.335 | 0.3740 | Yes |
| 54 | Slc7a11 | 2986 | 0.331 | 0.3779 | Yes |
| 55 | Bcat1 | 3265 | 0.314 | 0.3695 | Yes |
| 56 | Idh1 | 3429 | 0.304 | 0.3667 | Yes |
| 57 | Btg2 | 3431 | 0.304 | 0.3721 | Yes |
| 58 | Prdx1 | 3554 | 0.296 | 0.3713 | Yes |
| 59 | Cct6a | 3572 | 0.295 | 0.3757 | Yes |
| 60 | Ifi30 | 3618 | 0.292 | 0.3786 | Yes |
| 61 | Sc5d | 3648 | 0.291 | 0.3824 | Yes |
| 62 | Mcm4 | 3705 | 0.289 | 0.3847 | Yes |
| 63 | Ykt6 | 3735 | 0.286 | 0.3884 | Yes |
| 64 | Rrm2 | 3748 | 0.285 | 0.3929 | Yes |
| 65 | Atp6v1d | 3771 | 0.284 | 0.3968 | Yes |
| 66 | Coro1a | 3788 | 0.283 | 0.4011 | Yes |
| 67 | Gtf2h1 | 3909 | 0.276 | 0.4000 | Yes |
| 68 | Mcm2 | 3914 | 0.276 | 0.4047 | Yes |
| 69 | Gla | 3930 | 0.275 | 0.4089 | Yes |
| 70 | Uso1 | 3936 | 0.275 | 0.4135 | Yes |
| 71 | M6pr | 3947 | 0.274 | 0.4179 | Yes |
| 72 | Psma3 | 3950 | 0.274 | 0.4227 | Yes |
| 73 | Eno1b | 3951 | 0.274 | 0.4276 | Yes |
| 74 | Pgk1 | 4172 | 0.264 | 0.4212 | Yes |
| 75 | Fads1 | 4218 | 0.261 | 0.4236 | Yes |
| 76 | Nfyc | 4251 | 0.258 | 0.4266 | Yes |
| 77 | Psat1 | 4309 | 0.254 | 0.4283 | Yes |
| 78 | Asns | 4362 | 0.251 | 0.4302 | Yes |
| 79 | Elovl5 | 4390 | 0.250 | 0.4333 | Yes |
| 80 | Slc6a6 | 4454 | 0.245 | 0.4345 | Yes |
| 81 | Map2k3 | 4579 | 0.240 | 0.4325 | Yes |
| 82 | Uchl5 | 4641 | 0.238 | 0.4337 | Yes |
| 83 | Nupr1 | 4682 | 0.235 | 0.4359 | Yes |
| 84 | Cacybp | 4798 | 0.229 | 0.4342 | Yes |
| 85 | Skap2 | 4910 | 0.222 | 0.4325 | Yes |
| 86 | Cdc25a | 5099 | 0.212 | 0.4269 | Yes |
| 87 | Hspe1 | 5133 | 0.211 | 0.4290 | Yes |
| 88 | Polr3g | 5137 | 0.211 | 0.4326 | Yes |
| 89 | Sqstm1 | 5156 | 0.210 | 0.4354 | Yes |
| 90 | Ppa1 | 5183 | 0.208 | 0.4378 | Yes |
| 91 | Ufm1 | 5334 | 0.200 | 0.4338 | No |
| 92 | Nup205 | 5373 | 0.197 | 0.4355 | No |
| 93 | Ifrd1 | 5462 | 0.193 | 0.4345 | No |
| 94 | Psmd12 | 5533 | 0.189 | 0.4343 | No |
| 95 | Pfkl | 5644 | 0.189 | 0.4322 | No |
| 96 | Nfil3 | 5653 | 0.189 | 0.4351 | No |
| 97 | Psmb5 | 5737 | 0.183 | 0.4342 | No |
| 98 | Pdk1 | 5830 | 0.178 | 0.4328 | No |
| 99 | Gsr | 5858 | 0.177 | 0.4346 | No |
| 100 | Sla | 5913 | 0.175 | 0.4350 | No |
| 101 | Slc37a4 | 6273 | 0.158 | 0.4197 | No |
| 102 | Vldlr | 6278 | 0.158 | 0.4223 | No |
| 103 | Acsl3 | 6529 | 0.148 | 0.4124 | No |
| 104 | Ube2d3 | 6542 | 0.148 | 0.4144 | No |
| 105 | Got1 | 6758 | 0.136 | 0.4060 | No |
| 106 | Hk2 | 6804 | 0.134 | 0.4061 | No |
| 107 | Aurka | 6866 | 0.129 | 0.4054 | No |
| 108 | Pitpnb | 7402 | 0.107 | 0.3803 | No |
| 109 | Acaca | 7447 | 0.105 | 0.3800 | No |
| 110 | Trib3 | 7474 | 0.104 | 0.3805 | No |
| 111 | Me1 | 7534 | 0.101 | 0.3793 | No |
| 112 | Fdxr | 7626 | 0.097 | 0.3765 | No |
| 113 | Sec11a | 7686 | 0.094 | 0.3752 | No |
| 114 | Gsk3b | 7712 | 0.093 | 0.3756 | No |
| 115 | Tpi1 | 7849 | 0.091 | 0.3704 | No |
| 116 | Ccng1 | 8061 | 0.081 | 0.3612 | No |
| 117 | Mthfd2 | 8140 | 0.077 | 0.3586 | No |
| 118 | Shmt2 | 8149 | 0.077 | 0.3596 | No |
| 119 | Hmbs | 8390 | 0.066 | 0.3487 | No |
| 120 | Phgdh | 8532 | 0.061 | 0.3427 | No |
| 121 | Ctsc | 8610 | 0.057 | 0.3398 | No |
| 122 | Psmc6 | 8676 | 0.054 | 0.3375 | No |
| 123 | Ldha | 8794 | 0.049 | 0.3325 | No |
| 124 | Ak4 | 8828 | 0.048 | 0.3316 | No |
| 125 | Fads2 | 8869 | 0.046 | 0.3304 | No |
| 126 | Tfrc | 8908 | 0.044 | 0.3293 | No |
| 127 | Slc1a5 | 8966 | 0.041 | 0.3272 | No |
| 128 | Hmgcs1 | 8974 | 0.041 | 0.3276 | No |
| 129 | Wars1 | 9060 | 0.038 | 0.3239 | No |
| 130 | Cops5 | 9171 | 0.033 | 0.3190 | No |
| 131 | Slc7a5 | 9269 | 0.029 | 0.3146 | No |
| 132 | Tomm40 | 9293 | 0.028 | 0.3140 | No |
| 133 | Gbe1 | 9357 | 0.025 | 0.3112 | No |
| 134 | Tuba4a | 9460 | 0.020 | 0.3064 | No |
| 135 | G6pdx | 9549 | 0.016 | 0.3023 | No |
| 136 | Nmt1 | 9846 | 0.002 | 0.2874 | No |
| 137 | Gmps | 9998 | -0.002 | 0.2798 | No |
| 138 | Pgm1 | 10146 | -0.009 | 0.2726 | No |
| 139 | Immt | 10209 | -0.011 | 0.2696 | No |
| 140 | Nampt | 10319 | -0.015 | 0.2644 | No |
| 141 | Psmc2 | 10491 | -0.022 | 0.2562 | No |
| 142 | Sytl2 | 10526 | -0.024 | 0.2549 | No |
| 143 | Pdap1 | 10628 | -0.028 | 0.2503 | No |
| 144 | Lgmn | 10734 | -0.032 | 0.2456 | No |
| 145 | Cd9 | 11022 | -0.044 | 0.2319 | No |
| 146 | Tubg1 | 11144 | -0.049 | 0.2267 | No |
| 147 | Rpa1 | 11163 | -0.050 | 0.2267 | No |
| 148 | Adipor2 | 11382 | -0.061 | 0.2168 | No |
| 149 | Lta4h | 11470 | -0.065 | 0.2136 | No |
| 150 | Tmem97 | 11523 | -0.067 | 0.2122 | No |
| 151 | Itgb2 | 11541 | -0.068 | 0.2125 | No |
| 152 | Psmg1 | 11722 | -0.076 | 0.2048 | No |
| 153 | Glrx | 11811 | -0.081 | 0.2018 | No |
| 154 | Psma4 | 11823 | -0.082 | 0.2027 | No |
| 155 | Cfp | 11846 | -0.084 | 0.2031 | No |
| 156 | Sdf2l1 | 11887 | -0.086 | 0.2026 | No |
| 157 | Dhcr7 | 12580 | -0.114 | 0.1698 | No |
| 158 | Eif2s2 | 12583 | -0.114 | 0.1717 | No |
| 159 | Add3 | 12846 | -0.124 | 0.1607 | No |
| 160 | Slc2a1 | 12993 | -0.132 | 0.1557 | No |
| 161 | Rdh11 | 13075 | -0.136 | 0.1541 | No |
| 162 | Gclc | 13077 | -0.136 | 0.1564 | No |
| 163 | Psmd13 | 13573 | -0.159 | 0.1343 | No |
| 164 | Fkbp2 | 13776 | -0.170 | 0.1272 | No |
| 165 | Sord | 13805 | -0.171 | 0.1288 | No |
| 166 | Ppp1r15a | 13832 | -0.173 | 0.1306 | No |
| 167 | Qdpr | 14029 | -0.183 | 0.1240 | No |
| 168 | Tbk1 | 14204 | -0.191 | 0.1186 | No |
| 169 | Mthfd2l | 14231 | -0.192 | 0.1208 | No |
| 170 | Nfkbib | 14304 | -0.195 | 0.1206 | No |
| 171 | Cdkn1a | 14725 | -0.216 | 0.1033 | No |
| 172 | Tcea1 | 14966 | -0.227 | 0.0953 | No |
| 173 | Egln3 | 15041 | -0.232 | 0.0957 | No |
| 174 | Eef1e1 | 15590 | -0.256 | 0.0726 | No |
| 175 | Ebp | 15947 | -0.276 | 0.0596 | No |
| 176 | Mllt11 | 16500 | -0.307 | 0.0373 | No |
| 177 | Pik3r3 | 17047 | -0.341 | 0.0159 | No |
| 178 | Srd5a1 | 17208 | -0.352 | 0.0141 | No |
| 179 | Arpc5l | 17367 | -0.363 | 0.0126 | No |
| 180 | Tes | 18090 | -0.424 | -0.0162 | No |
| 181 | Slc2a3 | 18216 | -0.437 | -0.0147 | No |
| 182 | Elovl6 | 18563 | -0.475 | -0.0236 | No |
| 183 | Psph | 18893 | -0.514 | -0.0310 | No |
| 184 | Rit1 | 18919 | -0.517 | -0.0231 | No |
| 185 | Ddit3 | 18932 | -0.518 | -0.0144 | No |
| 186 | Slc1a4 | 19023 | -0.533 | -0.0094 | No |
| 187 | Niban1 | 19340 | -0.596 | -0.0147 | No |
| 188 | Cxcr4 | 19477 | -0.631 | -0.0103 | No |
| 189 | Dhfr | 19590 | -0.661 | -0.0041 | No |
| 190 | Dapp1 | 19716 | -0.710 | 0.0023 | No |
| 191 | Plod2 | 19778 | -0.742 | 0.0125 | No |

