| Dataset | GMP.GMP.mono_Pheno.cls #Group3_versus_Group4.GMP.mono_Pheno.cls #Group3_versus_Group4_repos |
| Phenotype | GMP.mono_Pheno.cls#Group3_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_ESTROGEN_RESPONSE_EARLY |
| Enrichment Score (ES) | -0.18791792 |
| Normalized Enrichment Score (NES) | -0.86048967 |
| Nominal p-value | 0.73146296 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Ccnd1 | 222 | 0.756 | 0.0117 | Yes |
| 2 | Rasgrp1 | 337 | 0.686 | 0.0261 | Yes |
| 3 | Clic3 | 453 | 0.642 | 0.0392 | Yes |
| 4 | Stc2 | 480 | 0.637 | 0.0560 | Yes |
| 5 | Gfra1 | 772 | 0.556 | 0.0591 | Yes |
| 6 | Slc1a4 | 858 | 0.535 | 0.0705 | Yes |
| 7 | Sec14l2 | 898 | 0.527 | 0.0836 | Yes |
| 8 | Rhod | 905 | 0.526 | 0.0981 | Yes |
| 9 | Zfp185 | 994 | 0.505 | 0.1085 | Yes |
| 10 | Krt18 | 1130 | 0.483 | 0.1163 | Yes |
| 11 | Fcmr | 1204 | 0.475 | 0.1265 | Yes |
| 12 | Tubb2b | 1205 | 0.475 | 0.1398 | Yes |
| 13 | Ttc39a | 1257 | 0.472 | 0.1508 | Yes |
| 14 | Bcl11b | 1343 | 0.458 | 0.1601 | Yes |
| 15 | Hr | 1525 | 0.444 | 0.1648 | Yes |
| 16 | Syngr1 | 2239 | 0.375 | 0.1449 | Yes |
| 17 | Ovol2 | 2428 | 0.364 | 0.1471 | Yes |
| 18 | Tsku | 2432 | 0.364 | 0.1571 | Yes |
| 19 | Fdft1 | 2752 | 0.339 | 0.1531 | Yes |
| 20 | Ptges | 2954 | 0.322 | 0.1535 | Yes |
| 21 | Tpd52l1 | 3067 | 0.314 | 0.1576 | Yes |
| 22 | Pmaip1 | 3165 | 0.309 | 0.1621 | Yes |
| 23 | Xbp1 | 3224 | 0.304 | 0.1681 | Yes |
| 24 | Slc22a5 | 3321 | 0.297 | 0.1724 | Yes |
| 25 | Pgr | 3365 | 0.294 | 0.1788 | Yes |
| 26 | Gla | 3437 | 0.293 | 0.1840 | Yes |
| 27 | Hes1 | 3934 | 0.271 | 0.1705 | No |
| 28 | Syt12 | 3948 | 0.271 | 0.1775 | No |
| 29 | Cxcl12 | 4316 | 0.254 | 0.1690 | No |
| 30 | Flnb | 4391 | 0.252 | 0.1729 | No |
| 31 | Endod1 | 4696 | 0.238 | 0.1666 | No |
| 32 | Slc2a1 | 4725 | 0.236 | 0.1720 | No |
| 33 | Il6st | 4790 | 0.234 | 0.1759 | No |
| 34 | Il17rb | 4881 | 0.230 | 0.1785 | No |
| 35 | Blvrb | 5011 | 0.223 | 0.1792 | No |
| 36 | Dlc1 | 5055 | 0.221 | 0.1836 | No |
| 37 | Tjp3 | 5346 | 0.207 | 0.1770 | No |
| 38 | Retreg1 | 5787 | 0.189 | 0.1636 | No |
| 39 | Add3 | 5814 | 0.188 | 0.1677 | No |
| 40 | Wwc1 | 6164 | 0.175 | 0.1578 | No |
| 41 | Lrig1 | 6170 | 0.175 | 0.1624 | No |
| 42 | Farp1 | 6715 | 0.159 | 0.1437 | No |
| 43 | Slc16a1 | 6774 | 0.156 | 0.1456 | No |
| 44 | Fkbp4 | 6785 | 0.156 | 0.1496 | No |
| 45 | Kdm4b | 6804 | 0.155 | 0.1531 | No |
| 46 | Sema3b | 6979 | 0.150 | 0.1499 | No |
| 47 | Adcy9 | 7088 | 0.145 | 0.1494 | No |
| 48 | Akap1 | 7134 | 0.143 | 0.1515 | No |
| 49 | Ppif | 7161 | 0.142 | 0.1543 | No |
| 50 | Amfr | 7271 | 0.138 | 0.1536 | No |
| 51 | Reep1 | 7309 | 0.137 | 0.1558 | No |
| 52 | Sybu | 7515 | 0.130 | 0.1507 | No |
| 53 | Abat | 7560 | 0.129 | 0.1525 | No |
| 54 | Dynlt3 | 7651 | 0.125 | 0.1521 | No |
| 55 | Pex11a | 7671 | 0.125 | 0.1548 | No |
| 56 | Ablim1 | 7917 | 0.117 | 0.1477 | No |
| 57 | Sult2b1 | 7985 | 0.115 | 0.1480 | No |
| 58 | Foxc1 | 8242 | 0.108 | 0.1401 | No |
| 59 | Scarb1 | 8713 | 0.094 | 0.1227 | No |
| 60 | Celsr1 | 8966 | 0.086 | 0.1144 | No |
| 61 | Med13l | 9248 | 0.079 | 0.1046 | No |
| 62 | Bcl2 | 9513 | 0.072 | 0.0954 | No |
| 63 | Mapt | 9599 | 0.070 | 0.0937 | No |
| 64 | Fasn | 9821 | 0.064 | 0.0861 | No |
| 65 | Nav2 | 9951 | 0.060 | 0.0823 | No |
| 66 | Gja1 | 10129 | 0.056 | 0.0763 | No |
| 67 | Ar | 10471 | 0.047 | 0.0631 | No |
| 68 | Calcr | 10502 | 0.046 | 0.0631 | No |
| 69 | Cant1 | 10632 | 0.043 | 0.0588 | No |
| 70 | Rps6ka2 | 10640 | 0.043 | 0.0597 | No |
| 71 | Med24 | 10783 | 0.039 | 0.0548 | No |
| 72 | Elf1 | 11157 | 0.029 | 0.0397 | No |
| 73 | B4galt1 | 11412 | 0.023 | 0.0295 | No |
| 74 | Dhrs3 | 11440 | 0.022 | 0.0289 | No |
| 75 | Rab31 | 11604 | 0.018 | 0.0225 | No |
| 76 | Tmem164 | 11616 | 0.018 | 0.0225 | No |
| 77 | Car12 | 11658 | 0.017 | 0.0212 | No |
| 78 | Slc7a5 | 11874 | 0.011 | 0.0124 | No |
| 79 | Cish | 11875 | 0.011 | 0.0127 | No |
| 80 | Nrip1 | 12124 | 0.005 | 0.0023 | No |
| 81 | Pdlim3 | 12367 | 0.000 | -0.0081 | No |
| 82 | Slc39a6 | 12700 | -0.001 | -0.0222 | No |
| 83 | Rrp12 | 12844 | -0.005 | -0.0282 | No |
| 84 | Klf4 | 12885 | -0.006 | -0.0297 | No |
| 85 | Wfs1 | 12953 | -0.008 | -0.0323 | No |
| 86 | Elovl5 | 12961 | -0.008 | -0.0324 | No |
| 87 | Fos | 12979 | -0.008 | -0.0329 | No |
| 88 | Abca3 | 13286 | -0.016 | -0.0455 | No |
| 89 | Abhd2 | 13306 | -0.016 | -0.0459 | No |
| 90 | Nxt1 | 13314 | -0.017 | -0.0457 | No |
| 91 | Ncor2 | 13395 | -0.019 | -0.0486 | No |
| 92 | Jak2 | 13404 | -0.019 | -0.0484 | No |
| 93 | P2ry2 | 13408 | -0.019 | -0.0480 | No |
| 94 | Aff1 | 13490 | -0.021 | -0.0508 | No |
| 95 | Muc1 | 13705 | -0.026 | -0.0592 | No |
| 96 | Isg20l2 | 13710 | -0.026 | -0.0587 | No |
| 97 | Aldh3b1 | 13776 | -0.028 | -0.0606 | No |
| 98 | Klf10 | 13978 | -0.033 | -0.0683 | No |
| 99 | Elovl2 | 14119 | -0.037 | -0.0732 | No |
| 100 | Tiparp | 14138 | -0.037 | -0.0729 | No |
| 101 | Slc37a1 | 14242 | -0.040 | -0.0762 | No |
| 102 | Nadsyn1 | 14493 | -0.046 | -0.0856 | No |
| 103 | Myc | 14639 | -0.050 | -0.0904 | No |
| 104 | Slc24a3 | 14704 | -0.052 | -0.0917 | No |
| 105 | Svil | 14933 | -0.058 | -0.0998 | No |
| 106 | Tmprss3 | 14961 | -0.059 | -0.0993 | No |
| 107 | Itpk1 | 14980 | -0.059 | -0.0984 | No |
| 108 | Slc7a2 | 15009 | -0.060 | -0.0979 | No |
| 109 | Pdzk1 | 15032 | -0.061 | -0.0971 | No |
| 110 | Thsd4 | 15118 | -0.063 | -0.0990 | No |
| 111 | Myb | 15126 | -0.064 | -0.0975 | No |
| 112 | Podxl | 15175 | -0.065 | -0.0977 | No |
| 113 | Mybbp1a | 15204 | -0.066 | -0.0971 | No |
| 114 | Rhobtb3 | 15715 | -0.078 | -0.1166 | No |
| 115 | Cd44 | 15844 | -0.081 | -0.1198 | No |
| 116 | Opn3 | 16024 | -0.087 | -0.1250 | No |
| 117 | Dhcr7 | 16160 | -0.091 | -0.1282 | No |
| 118 | Igf1r | 16205 | -0.092 | -0.1275 | No |
| 119 | Tgm2 | 16368 | -0.095 | -0.1317 | No |
| 120 | Aqp3 | 16489 | -0.099 | -0.1341 | No |
| 121 | Sfn | 16515 | -0.100 | -0.1323 | No |
| 122 | Mpped2 | 16618 | -0.103 | -0.1338 | No |
| 123 | Ugcg | 16780 | -0.108 | -0.1377 | No |
| 124 | Fkbp5 | 17007 | -0.115 | -0.1441 | No |
| 125 | Asb13 | 17144 | -0.120 | -0.1465 | No |
| 126 | Papss2 | 17332 | -0.126 | -0.1510 | No |
| 127 | Cyp26b1 | 17335 | -0.126 | -0.1475 | No |
| 128 | Kcnk5 | 17689 | -0.137 | -0.1587 | No |
| 129 | Greb1 | 17718 | -0.138 | -0.1561 | No |
| 130 | Deptor | 17795 | -0.141 | -0.1553 | No |
| 131 | Rbbp8 | 17864 | -0.143 | -0.1542 | No |
| 132 | Igfbp4 | 17922 | -0.145 | -0.1526 | No |
| 133 | Bag1 | 18072 | -0.151 | -0.1547 | No |
| 134 | Inpp5f | 18128 | -0.152 | -0.1528 | No |
| 135 | Tbc1d30 | 18181 | -0.154 | -0.1507 | No |
| 136 | Celsr2 | 18453 | -0.165 | -0.1576 | No |
| 137 | Tiam1 | 18554 | -0.170 | -0.1571 | No |
| 138 | Myof | 18774 | -0.180 | -0.1614 | No |
| 139 | Mindy1 | 18995 | -0.188 | -0.1655 | No |
| 140 | Ret | 19048 | -0.191 | -0.1624 | No |
| 141 | Calb2 | 19509 | -0.213 | -0.1760 | No |
| 142 | Krt8 | 19521 | -0.213 | -0.1705 | No |
| 143 | Slc19a2 | 19930 | -0.225 | -0.1816 | No |
| 144 | Gab2 | 19963 | -0.227 | -0.1766 | No |
| 145 | Sh3bp5 | 20079 | -0.233 | -0.1750 | No |
| 146 | Slc26a2 | 20187 | -0.240 | -0.1728 | No |
| 147 | Plaat3 | 20389 | -0.252 | -0.1743 | No |
| 148 | Mast4 | 20443 | -0.255 | -0.1694 | No |
| 149 | Cbfa2t3 | 20552 | -0.260 | -0.1667 | No |
| 150 | Rab17 | 20553 | -0.260 | -0.1594 | No |
| 151 | Tob1 | 20608 | -0.261 | -0.1544 | No |
| 152 | Anxa9 | 20799 | -0.274 | -0.1548 | No |
| 153 | Kazn | 20832 | -0.276 | -0.1485 | No |
| 154 | Arl3 | 20934 | -0.284 | -0.1448 | No |
| 155 | Snx24 | 21045 | -0.287 | -0.1414 | No |
| 156 | Bhlhe40 | 21092 | -0.291 | -0.1352 | No |
| 157 | Scnn1a | 21352 | -0.310 | -0.1376 | No |
| 158 | Unc119 | 21649 | -0.324 | -0.1411 | No |
| 159 | Mybl1 | 21650 | -0.325 | -0.1320 | No |
| 160 | Siah2 | 21812 | -0.337 | -0.1294 | No |
| 161 | Rara | 21964 | -0.351 | -0.1260 | No |
| 162 | Fhl2 | 22029 | -0.356 | -0.1188 | No |
| 163 | Olfm1 | 22122 | -0.368 | -0.1124 | No |
| 164 | Rapgefl1 | 22150 | -0.371 | -0.1031 | No |
| 165 | Tgif2 | 22214 | -0.377 | -0.0952 | No |
| 166 | Frk | 22463 | -0.407 | -0.0944 | No |
| 167 | Olfml3 | 22890 | -0.475 | -0.0993 | No |
| 168 | Adcy1 | 23150 | -0.520 | -0.0957 | No |
| 169 | Chpt1 | 23194 | -0.534 | -0.0826 | No |
| 170 | Mlph | 23391 | -0.615 | -0.0737 | No |
| 171 | Mreg | 23451 | -0.645 | -0.0581 | No |
| 172 | Slc1a1 | 23467 | -0.656 | -0.0404 | No |
| 173 | Slc27a2 | 23582 | -0.817 | -0.0223 | No |
| 174 | Esrp2 | 23592 | -0.858 | 0.0014 | No |

