| Dataset | GMP.GMP.mono_Pheno.cls #Group2_versus_Group3.GMP.mono_Pheno.cls #Group2_versus_Group3_repos |
| Phenotype | GMP.mono_Pheno.cls#Group2_versus_Group3_repos |
| Upregulated in class | 1 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | 0.51803595 |
| Normalized Enrichment Score (NES) | 1.6738299 |
| Nominal p-value | 0.034068137 |
| FDR q-value | 0.1968179 |
| FWER p-Value | 0.179 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Acsl3 | 33 | 0.969 | 0.0175 | Yes |
| 2 | Hspa9 | 83 | 0.816 | 0.0312 | Yes |
| 3 | Bhlhe40 | 95 | 0.795 | 0.0462 | Yes |
| 4 | Hspd1 | 121 | 0.768 | 0.0601 | Yes |
| 5 | Slc7a11 | 122 | 0.767 | 0.0750 | Yes |
| 6 | Hsp90b1 | 131 | 0.761 | 0.0895 | Yes |
| 7 | Canx | 144 | 0.751 | 0.1036 | Yes |
| 8 | Fads1 | 155 | 0.740 | 0.1176 | Yes |
| 9 | Ctsc | 158 | 0.736 | 0.1318 | Yes |
| 10 | Tfrc | 218 | 0.697 | 0.1429 | Yes |
| 11 | Pgk1 | 277 | 0.662 | 0.1533 | Yes |
| 12 | Cyp51 | 278 | 0.660 | 0.1661 | Yes |
| 13 | Rrp9 | 340 | 0.628 | 0.1758 | Yes |
| 14 | Hspa4 | 371 | 0.614 | 0.1864 | Yes |
| 15 | Idi1 | 414 | 0.603 | 0.1964 | Yes |
| 16 | Hmbs | 505 | 0.577 | 0.2037 | Yes |
| 17 | Rpn1 | 538 | 0.568 | 0.2134 | Yes |
| 18 | Ssr1 | 570 | 0.562 | 0.2230 | Yes |
| 19 | Stip1 | 703 | 0.530 | 0.2277 | Yes |
| 20 | Gla | 752 | 0.523 | 0.2358 | Yes |
| 21 | Trib3 | 769 | 0.520 | 0.2453 | Yes |
| 22 | Hspa5 | 816 | 0.513 | 0.2533 | Yes |
| 23 | Calr | 854 | 0.507 | 0.2616 | Yes |
| 24 | Stard4 | 879 | 0.502 | 0.2703 | Yes |
| 25 | Psmc4 | 881 | 0.501 | 0.2800 | Yes |
| 26 | Ero1a | 953 | 0.491 | 0.2866 | Yes |
| 27 | Fgl2 | 1049 | 0.476 | 0.2918 | Yes |
| 28 | Sqle | 1067 | 0.473 | 0.3002 | Yes |
| 29 | Uso1 | 1095 | 0.470 | 0.3082 | Yes |
| 30 | Nampt | 1133 | 0.465 | 0.3157 | Yes |
| 31 | Srd5a1 | 1223 | 0.456 | 0.3208 | Yes |
| 32 | Aurka | 1291 | 0.448 | 0.3266 | Yes |
| 33 | Rrm2 | 1350 | 0.441 | 0.3327 | Yes |
| 34 | Etf1 | 1396 | 0.439 | 0.3394 | Yes |
| 35 | Rit1 | 1570 | 0.420 | 0.3402 | Yes |
| 36 | Mcm2 | 1629 | 0.413 | 0.3457 | Yes |
| 37 | Hmgcs1 | 1652 | 0.411 | 0.3528 | Yes |
| 38 | Edem1 | 1653 | 0.411 | 0.3608 | Yes |
| 39 | Cyb5b | 1678 | 0.408 | 0.3677 | Yes |
| 40 | Nupr1 | 1681 | 0.408 | 0.3756 | Yes |
| 41 | Abcf2 | 1790 | 0.398 | 0.3787 | Yes |
| 42 | Tm7sf2 | 1804 | 0.397 | 0.3859 | Yes |
| 43 | Actr2 | 1867 | 0.393 | 0.3909 | Yes |
| 44 | Txnrd1 | 1992 | 0.384 | 0.3930 | Yes |
| 45 | Acly | 2001 | 0.383 | 0.4002 | Yes |
| 46 | Pfkl | 2136 | 0.371 | 0.4017 | Yes |
| 47 | Mcm4 | 2234 | 0.364 | 0.4046 | Yes |
| 48 | Asns | 2239 | 0.363 | 0.4115 | Yes |
| 49 | Pitpnb | 2357 | 0.355 | 0.4134 | Yes |
| 50 | M6pr | 2395 | 0.352 | 0.4187 | Yes |
| 51 | Got1 | 2534 | 0.344 | 0.4195 | Yes |
| 52 | Ldlr | 2558 | 0.343 | 0.4252 | Yes |
| 53 | Plk1 | 2589 | 0.340 | 0.4305 | Yes |
| 54 | Hspe1 | 2682 | 0.334 | 0.4331 | Yes |
| 55 | Serp1 | 2712 | 0.332 | 0.4383 | Yes |
| 56 | Me1 | 2715 | 0.332 | 0.4447 | Yes |
| 57 | Hmgcr | 2717 | 0.332 | 0.4511 | Yes |
| 58 | Slc1a4 | 2749 | 0.329 | 0.4562 | Yes |
| 59 | Ddx39a | 2753 | 0.328 | 0.4625 | Yes |
| 60 | Rdh11 | 2842 | 0.322 | 0.4650 | Yes |
| 61 | P4ha1 | 2987 | 0.313 | 0.4649 | Yes |
| 62 | Ufm1 | 3024 | 0.311 | 0.4694 | Yes |
| 63 | Rab1a | 3110 | 0.307 | 0.4718 | Yes |
| 64 | Ak4 | 3113 | 0.307 | 0.4777 | Yes |
| 65 | Cacybp | 3128 | 0.307 | 0.4831 | Yes |
| 66 | Fads2 | 3366 | 0.293 | 0.4786 | Yes |
| 67 | Hk2 | 3448 | 0.290 | 0.4808 | Yes |
| 68 | Psmc2 | 3639 | 0.281 | 0.4782 | Yes |
| 69 | Gpi1 | 3692 | 0.278 | 0.4814 | Yes |
| 70 | Gsr | 3717 | 0.276 | 0.4857 | Yes |
| 71 | Ppia | 3933 | 0.265 | 0.4817 | Yes |
| 72 | Ifrd1 | 3948 | 0.264 | 0.4862 | Yes |
| 73 | Cct6a | 3980 | 0.263 | 0.4900 | Yes |
| 74 | Gmps | 4155 | 0.254 | 0.4875 | Yes |
| 75 | Psat1 | 4204 | 0.251 | 0.4904 | Yes |
| 76 | Itgb2 | 4213 | 0.250 | 0.4949 | Yes |
| 77 | Pno1 | 4388 | 0.241 | 0.4922 | Yes |
| 78 | Plod2 | 4394 | 0.241 | 0.4967 | Yes |
| 79 | Skap2 | 4405 | 0.241 | 0.5009 | Yes |
| 80 | Shmt2 | 4463 | 0.238 | 0.5031 | Yes |
| 81 | Insig1 | 4466 | 0.238 | 0.5076 | Yes |
| 82 | Aldoa | 4756 | 0.227 | 0.4997 | Yes |
| 83 | Atp2a2 | 4812 | 0.225 | 0.5017 | Yes |
| 84 | G6pdx | 4841 | 0.223 | 0.5049 | Yes |
| 85 | Cdc25a | 5075 | 0.212 | 0.4991 | Yes |
| 86 | Ccng1 | 5224 | 0.205 | 0.4967 | Yes |
| 87 | Ifi30 | 5234 | 0.204 | 0.5003 | Yes |
| 88 | Gsk3b | 5305 | 0.201 | 0.5012 | Yes |
| 89 | Vldlr | 5335 | 0.201 | 0.5039 | Yes |
| 90 | Acaca | 5485 | 0.194 | 0.5013 | Yes |
| 91 | Map2k3 | 5667 | 0.187 | 0.4972 | Yes |
| 92 | Tes | 5686 | 0.186 | 0.5001 | Yes |
| 93 | Ppa1 | 5720 | 0.184 | 0.5023 | Yes |
| 94 | Slc7a5 | 5728 | 0.184 | 0.5056 | Yes |
| 95 | Tomm40 | 5756 | 0.183 | 0.5080 | Yes |
| 96 | Psmd13 | 5809 | 0.181 | 0.5093 | Yes |
| 97 | Gga2 | 5906 | 0.177 | 0.5086 | Yes |
| 98 | Pdk1 | 5907 | 0.177 | 0.5121 | Yes |
| 99 | Nup205 | 5910 | 0.177 | 0.5154 | Yes |
| 100 | Immt | 6058 | 0.171 | 0.5125 | Yes |
| 101 | Idh1 | 6094 | 0.170 | 0.5143 | Yes |
| 102 | Xbp1 | 6113 | 0.169 | 0.5168 | Yes |
| 103 | Bub1 | 6162 | 0.167 | 0.5180 | Yes |
| 104 | Prdx1 | 6308 | 0.162 | 0.5150 | No |
| 105 | Sord | 6406 | 0.158 | 0.5139 | No |
| 106 | Ube2d3 | 6452 | 0.157 | 0.5151 | No |
| 107 | Ddit4 | 6591 | 0.151 | 0.5121 | No |
| 108 | Rpa1 | 6670 | 0.148 | 0.5117 | No |
| 109 | Tmem97 | 6687 | 0.147 | 0.5139 | No |
| 110 | Gtf2h1 | 6824 | 0.142 | 0.5108 | No |
| 111 | Pnp | 6835 | 0.142 | 0.5132 | No |
| 112 | Psme3 | 6940 | 0.138 | 0.5114 | No |
| 113 | Sdf2l1 | 7053 | 0.134 | 0.5092 | No |
| 114 | Uchl5 | 7089 | 0.133 | 0.5103 | No |
| 115 | Psmd14 | 7215 | 0.127 | 0.5075 | No |
| 116 | Mthfd2 | 7252 | 0.126 | 0.5084 | No |
| 117 | Nfyc | 7290 | 0.125 | 0.5092 | No |
| 118 | Tpi1 | 7563 | 0.118 | 0.4999 | No |
| 119 | Psmc6 | 7811 | 0.110 | 0.4915 | No |
| 120 | Ppp1r15a | 8045 | 0.102 | 0.4836 | No |
| 121 | Bcat1 | 8074 | 0.101 | 0.4843 | No |
| 122 | Elovl5 | 8088 | 0.101 | 0.4857 | No |
| 123 | Elovl6 | 8109 | 0.100 | 0.4868 | No |
| 124 | Fdxr | 8177 | 0.098 | 0.4859 | No |
| 125 | Cops5 | 8487 | 0.087 | 0.4744 | No |
| 126 | Actr3 | 8651 | 0.082 | 0.4690 | No |
| 127 | Sec11a | 8689 | 0.080 | 0.4690 | No |
| 128 | Tcea1 | 8947 | 0.072 | 0.4594 | No |
| 129 | Slc6a6 | 9053 | 0.069 | 0.4563 | No |
| 130 | Pdap1 | 9202 | 0.063 | 0.4512 | No |
| 131 | Eno1b | 9276 | 0.061 | 0.4493 | No |
| 132 | Dhcr24 | 9452 | 0.055 | 0.4429 | No |
| 133 | Ykt6 | 9627 | 0.050 | 0.4364 | No |
| 134 | Psmd12 | 9653 | 0.049 | 0.4363 | No |
| 135 | Wars1 | 9824 | 0.044 | 0.4299 | No |
| 136 | Ldha | 9885 | 0.042 | 0.4281 | No |
| 137 | Fkbp2 | 10071 | 0.037 | 0.4210 | No |
| 138 | Nufip1 | 10121 | 0.035 | 0.4196 | No |
| 139 | Gclc | 10169 | 0.034 | 0.4182 | No |
| 140 | Add3 | 10420 | 0.026 | 0.4081 | No |
| 141 | Sc5d | 10460 | 0.025 | 0.4069 | No |
| 142 | Ccnf | 10945 | 0.010 | 0.3864 | No |
| 143 | Lta4h | 11025 | 0.007 | 0.3832 | No |
| 144 | Cxcr4 | 11053 | 0.007 | 0.3822 | No |
| 145 | Nfil3 | 11222 | 0.002 | 0.3750 | No |
| 146 | Nmt1 | 11377 | -0.001 | 0.3685 | No |
| 147 | Niban1 | 11708 | -0.012 | 0.3546 | No |
| 148 | Eif2s2 | 11716 | -0.013 | 0.3546 | No |
| 149 | Qdpr | 11754 | -0.014 | 0.3533 | No |
| 150 | Pik3r3 | 11832 | -0.016 | 0.3503 | No |
| 151 | Tbk1 | 11963 | -0.020 | 0.3451 | No |
| 152 | Psma3 | 12132 | -0.025 | 0.3385 | No |
| 153 | Lgmn | 12705 | -0.043 | 0.3149 | No |
| 154 | Nfkbib | 12849 | -0.048 | 0.3097 | No |
| 155 | Sla | 13187 | -0.060 | 0.2965 | No |
| 156 | Sytl2 | 13351 | -0.066 | 0.2908 | No |
| 157 | Psmg1 | 13383 | -0.067 | 0.2908 | No |
| 158 | Slc2a3 | 13439 | -0.069 | 0.2898 | No |
| 159 | Slc37a4 | 13605 | -0.074 | 0.2842 | No |
| 160 | Arpc5l | 13824 | -0.082 | 0.2765 | No |
| 161 | Cdkn1a | 13944 | -0.086 | 0.2731 | No |
| 162 | Slc1a5 | 14185 | -0.094 | 0.2646 | No |
| 163 | Phgdh | 14220 | -0.094 | 0.2650 | No |
| 164 | Cd9 | 14296 | -0.097 | 0.2637 | No |
| 165 | Psmb5 | 14378 | -0.100 | 0.2622 | No |
| 166 | Dhcr7 | 14413 | -0.101 | 0.2627 | No |
| 167 | Ebp | 14783 | -0.112 | 0.2492 | No |
| 168 | Cfp | 14934 | -0.118 | 0.2451 | No |
| 169 | Glrx | 15145 | -0.125 | 0.2385 | No |
| 170 | Psma4 | 15332 | -0.131 | 0.2331 | No |
| 171 | Atp6v1d | 15895 | -0.152 | 0.2121 | No |
| 172 | Dhfr | 16118 | -0.160 | 0.2057 | No |
| 173 | Btg2 | 16222 | -0.164 | 0.2045 | No |
| 174 | Adipor2 | 16287 | -0.166 | 0.2050 | No |
| 175 | Eef1e1 | 16485 | -0.172 | 0.2000 | No |
| 176 | Coro1a | 16624 | -0.178 | 0.1975 | No |
| 177 | Serpinh1 | 16827 | -0.184 | 0.1925 | No |
| 178 | Gbe1 | 17399 | -0.208 | 0.1722 | No |
| 179 | Cth | 17519 | -0.213 | 0.1712 | No |
| 180 | Ung | 17944 | -0.232 | 0.1576 | No |
| 181 | Igfbp5 | 18467 | -0.254 | 0.1403 | No |
| 182 | Pgm1 | 18732 | -0.264 | 0.1342 | No |
| 183 | Slc2a1 | 19341 | -0.291 | 0.1139 | No |
| 184 | Mllt11 | 19350 | -0.291 | 0.1192 | No |
| 185 | Tuba4a | 19400 | -0.294 | 0.1228 | No |
| 186 | Polr3g | 19678 | -0.309 | 0.1170 | No |
| 187 | Mthfd2l | 19701 | -0.311 | 0.1222 | No |
| 188 | Tubg1 | 19744 | -0.313 | 0.1265 | No |
| 189 | Sqstm1 | 20184 | -0.339 | 0.1143 | No |
| 190 | Egln3 | 20580 | -0.363 | 0.1045 | No |
| 191 | Psph | 20767 | -0.375 | 0.1039 | No |
| 192 | Ddit3 | 20997 | -0.390 | 0.1017 | No |
| 193 | Dapp1 | 22488 | -0.533 | 0.0485 | No |

