| Dataset | GMP.GMP.mono_Pheno.cls #Group1_versus_Group3.GMP.mono_Pheno.cls #Group1_versus_Group3_repos |
| Phenotype | GMP.mono_Pheno.cls#Group1_versus_Group3_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_HEME_METABOLISM |
| Enrichment Score (ES) | -0.2711532 |
| Normalized Enrichment Score (NES) | -1.376739 |
| Nominal p-value | 0.0729783 |
| FDR q-value | 0.7255012 |
| FWER p-Value | 0.654 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Slc7a11 | 549 | 0.562 | -0.0079 | No |
| 2 | Abcb6 | 1003 | 0.476 | -0.0142 | No |
| 3 | Kel | 1174 | 0.446 | -0.0091 | No |
| 4 | Myl4 | 1188 | 0.444 | 0.0026 | No |
| 5 | C3 | 1477 | 0.411 | 0.0016 | No |
| 6 | Mocos | 1724 | 0.388 | 0.0018 | No |
| 7 | Ctns | 2052 | 0.364 | -0.0022 | No |
| 8 | Slc30a1 | 2278 | 0.347 | -0.0022 | No |
| 9 | Arhgef12 | 2292 | 0.346 | 0.0068 | No |
| 10 | Htatip2 | 2303 | 0.345 | 0.0159 | No |
| 11 | Cast | 2425 | 0.334 | 0.0199 | No |
| 12 | Bach1 | 2547 | 0.322 | 0.0236 | No |
| 13 | Nfe2l1 | 3265 | 0.277 | 0.0006 | No |
| 14 | Mkrn1 | 3525 | 0.262 | -0.0032 | No |
| 15 | Bnip3l | 3633 | 0.256 | -0.0007 | No |
| 16 | Mxi1 | 3709 | 0.252 | 0.0030 | No |
| 17 | Daam1 | 3761 | 0.250 | 0.0077 | No |
| 18 | Marchf8 | 4100 | 0.233 | -0.0003 | No |
| 19 | Slc11a2 | 4330 | 0.226 | -0.0039 | No |
| 20 | Foxo3 | 4799 | 0.207 | -0.0181 | No |
| 21 | Ank1 | 4925 | 0.202 | -0.0179 | No |
| 22 | Ackr1 | 4935 | 0.202 | -0.0127 | No |
| 23 | Ranbp10 | 5035 | 0.197 | -0.0115 | No |
| 24 | Aldh6a1 | 5091 | 0.195 | -0.0085 | No |
| 25 | Kdm7a | 5114 | 0.194 | -0.0041 | No |
| 26 | Btg2 | 5190 | 0.193 | -0.0020 | No |
| 27 | Narf | 5229 | 0.191 | 0.0017 | No |
| 28 | Ucp2 | 5454 | 0.183 | -0.0029 | No |
| 29 | Sec14l1 | 5580 | 0.177 | -0.0033 | No |
| 30 | Blvrb | 5595 | 0.177 | 0.0010 | No |
| 31 | Mfhas1 | 5669 | 0.174 | 0.0027 | No |
| 32 | Hagh | 5772 | 0.171 | 0.0030 | No |
| 33 | Fbxo34 | 5854 | 0.167 | 0.0041 | No |
| 34 | Ctse | 5871 | 0.166 | 0.0080 | No |
| 35 | Hmbs | 5928 | 0.164 | 0.0102 | No |
| 36 | Slc22a4 | 6001 | 0.162 | 0.0116 | No |
| 37 | Pcx | 6017 | 0.161 | 0.0154 | No |
| 38 | Aqp3 | 6116 | 0.157 | 0.0155 | No |
| 39 | Slc30a10 | 6127 | 0.156 | 0.0194 | No |
| 40 | Ccdc28a | 6227 | 0.153 | 0.0194 | No |
| 41 | Ncoa4 | 6459 | 0.145 | 0.0135 | No |
| 42 | Eif2ak1 | 6718 | 0.136 | 0.0063 | No |
| 43 | Rnf123 | 6793 | 0.134 | 0.0068 | No |
| 44 | Tspan5 | 6875 | 0.131 | 0.0070 | No |
| 45 | Dcaf11 | 6978 | 0.128 | 0.0061 | No |
| 46 | Nek7 | 6980 | 0.128 | 0.0096 | No |
| 47 | Blvra | 7017 | 0.127 | 0.0116 | No |
| 48 | Sdcbp | 7171 | 0.122 | 0.0084 | No |
| 49 | Ypel5 | 7372 | 0.116 | 0.0031 | No |
| 50 | Synj1 | 7486 | 0.114 | 0.0014 | No |
| 51 | Nr3c1 | 7549 | 0.112 | 0.0018 | No |
| 52 | Rbm5 | 7696 | 0.107 | -0.0015 | No |
| 53 | H1f0 | 7700 | 0.107 | 0.0013 | No |
| 54 | Picalm | 7751 | 0.106 | 0.0021 | No |
| 55 | Gmps | 7792 | 0.105 | 0.0033 | No |
| 56 | Pigq | 7990 | 0.098 | -0.0024 | No |
| 57 | Mpp1 | 8082 | 0.095 | -0.0037 | No |
| 58 | Gata1 | 8090 | 0.095 | -0.0013 | No |
| 59 | Trim10 | 8161 | 0.093 | -0.0018 | No |
| 60 | Fbxo9 | 8280 | 0.090 | -0.0043 | No |
| 61 | Spta1 | 8346 | 0.088 | -0.0047 | No |
| 62 | Foxj2 | 8591 | 0.081 | -0.0129 | No |
| 63 | Epb41 | 8674 | 0.078 | -0.0142 | No |
| 64 | Usp15 | 8730 | 0.076 | -0.0144 | No |
| 65 | Btrc | 8798 | 0.074 | -0.0153 | No |
| 66 | Tyr | 8891 | 0.071 | -0.0172 | No |
| 67 | Mark3 | 8906 | 0.071 | -0.0159 | No |
| 68 | Atp6v0a1 | 8947 | 0.069 | -0.0157 | No |
| 69 | Abcg2 | 9344 | 0.059 | -0.0309 | No |
| 70 | Dmtn | 9362 | 0.058 | -0.0301 | No |
| 71 | Nudt4 | 9544 | 0.052 | -0.0364 | No |
| 72 | Tfdp2 | 9566 | 0.051 | -0.0358 | No |
| 73 | Ezh1 | 9592 | 0.051 | -0.0355 | No |
| 74 | Khnyn | 9710 | 0.047 | -0.0392 | No |
| 75 | Rnf19a | 9911 | 0.041 | -0.0466 | No |
| 76 | Tnrc6b | 9959 | 0.040 | -0.0475 | No |
| 77 | Tal1 | 10009 | 0.038 | -0.0486 | No |
| 78 | Sidt2 | 10034 | 0.037 | -0.0486 | No |
| 79 | P4ha2 | 10146 | 0.034 | -0.0524 | No |
| 80 | Dcun1d1 | 10486 | 0.023 | -0.0662 | No |
| 81 | Kat2b | 10553 | 0.021 | -0.0684 | No |
| 82 | Lamp2 | 10576 | 0.021 | -0.0688 | No |
| 83 | Riok3 | 10778 | 0.015 | -0.0770 | No |
| 84 | Xpo7 | 10889 | 0.012 | -0.0813 | No |
| 85 | Tfrc | 10979 | 0.009 | -0.0849 | No |
| 86 | Car1 | 10983 | 0.009 | -0.0847 | No |
| 87 | Slc4a1 | 11039 | 0.007 | -0.0869 | No |
| 88 | Nnt | 11113 | 0.006 | -0.0898 | No |
| 89 | Add2 | 11267 | 0.001 | -0.0963 | No |
| 90 | Snca | 11455 | -0.001 | -0.1043 | No |
| 91 | Rhd | 11459 | -0.001 | -0.1044 | No |
| 92 | Top1 | 11599 | -0.005 | -0.1102 | No |
| 93 | Bmp2k | 11670 | -0.007 | -0.1130 | No |
| 94 | Lpin2 | 11903 | -0.014 | -0.1225 | No |
| 95 | Trak2 | 12036 | -0.018 | -0.1276 | No |
| 96 | Fech | 12064 | -0.019 | -0.1282 | No |
| 97 | Xk | 12228 | -0.024 | -0.1345 | No |
| 98 | Fbxo7 | 12374 | -0.028 | -0.1399 | No |
| 99 | Acsl6 | 12754 | -0.038 | -0.1550 | No |
| 100 | Gapvd1 | 12793 | -0.039 | -0.1556 | No |
| 101 | Cdc27 | 13199 | -0.052 | -0.1714 | No |
| 102 | Slc66a2 | 13289 | -0.055 | -0.1737 | No |
| 103 | Minpp1 | 13377 | -0.058 | -0.1758 | No |
| 104 | Tspo2 | 13529 | -0.063 | -0.1805 | No |
| 105 | Add1 | 13566 | -0.064 | -0.1803 | No |
| 106 | Bpgm | 13573 | -0.064 | -0.1787 | No |
| 107 | Uros | 13604 | -0.066 | -0.1782 | No |
| 108 | Bsg | 13622 | -0.066 | -0.1771 | No |
| 109 | Fn3k | 13673 | -0.068 | -0.1774 | No |
| 110 | Agpat4 | 13777 | -0.071 | -0.1798 | No |
| 111 | Ppp2r5b | 13909 | -0.074 | -0.1834 | No |
| 112 | Osbp2 | 14022 | -0.078 | -0.1860 | No |
| 113 | Tcea1 | 14459 | -0.092 | -0.2021 | No |
| 114 | Igsf3 | 14480 | -0.093 | -0.2004 | No |
| 115 | Slc25a38 | 14524 | -0.094 | -0.1996 | No |
| 116 | E2f2 | 14717 | -0.100 | -0.2050 | No |
| 117 | Rhag | 14878 | -0.107 | -0.2089 | No |
| 118 | Ell2 | 15109 | -0.113 | -0.2156 | No |
| 119 | Tmcc2 | 15117 | -0.113 | -0.2128 | No |
| 120 | Ubac1 | 15138 | -0.114 | -0.2105 | No |
| 121 | Klf3 | 15155 | -0.115 | -0.2080 | No |
| 122 | Clcn3 | 15177 | -0.116 | -0.2057 | No |
| 123 | Cdr2 | 15213 | -0.117 | -0.2040 | No |
| 124 | Atg4a | 15254 | -0.118 | -0.2025 | No |
| 125 | Trim58 | 15820 | -0.138 | -0.2228 | No |
| 126 | Tns1 | 15835 | -0.138 | -0.2196 | No |
| 127 | Alad | 16020 | -0.146 | -0.2234 | No |
| 128 | Ctsb | 16170 | -0.151 | -0.2256 | No |
| 129 | Alas2 | 16231 | -0.153 | -0.2239 | No |
| 130 | Ppox | 16276 | -0.154 | -0.2216 | No |
| 131 | Vezf1 | 16355 | -0.157 | -0.2206 | No |
| 132 | Cir1 | 16365 | -0.157 | -0.2166 | No |
| 133 | Gclc | 16383 | -0.158 | -0.2130 | No |
| 134 | Selenbp1 | 16403 | -0.159 | -0.2094 | No |
| 135 | Nfe2 | 16554 | -0.164 | -0.2113 | No |
| 136 | Marchf2 | 16961 | -0.177 | -0.2238 | No |
| 137 | Htra2 | 17180 | -0.185 | -0.2280 | No |
| 138 | Rcl1 | 17422 | -0.194 | -0.2329 | No |
| 139 | Slc2a1 | 17670 | -0.204 | -0.2378 | No |
| 140 | Map2k3 | 18065 | -0.221 | -0.2485 | No |
| 141 | Klf1 | 18507 | -0.242 | -0.2607 | No |
| 142 | Psmd9 | 18753 | -0.253 | -0.2642 | Yes |
| 143 | Cpox | 18780 | -0.254 | -0.2583 | Yes |
| 144 | Tmem9b | 18996 | -0.262 | -0.2603 | Yes |
| 145 | Smox | 19004 | -0.263 | -0.2533 | Yes |
| 146 | Endod1 | 19166 | -0.270 | -0.2528 | Yes |
| 147 | Gypc | 19177 | -0.270 | -0.2457 | Yes |
| 148 | Gclm | 19187 | -0.271 | -0.2387 | Yes |
| 149 | Adipor1 | 19285 | -0.273 | -0.2353 | Yes |
| 150 | Aldh1l1 | 19315 | -0.275 | -0.2290 | Yes |
| 151 | Ermap | 19424 | -0.280 | -0.2259 | Yes |
| 152 | Ccnd3 | 19459 | -0.281 | -0.2196 | Yes |
| 153 | Sptb | 19531 | -0.285 | -0.2148 | Yes |
| 154 | Slc6a8 | 19582 | -0.288 | -0.2090 | Yes |
| 155 | Dcaf10 | 19612 | -0.289 | -0.2022 | Yes |
| 156 | Cat | 19687 | -0.292 | -0.1973 | Yes |
| 157 | Mboat2 | 19852 | -0.300 | -0.1961 | Yes |
| 158 | Optn | 19868 | -0.301 | -0.1884 | Yes |
| 159 | Rbm38 | 19871 | -0.301 | -0.1802 | Yes |
| 160 | Gde1 | 19909 | -0.303 | -0.1735 | Yes |
| 161 | Slc10a3 | 20054 | -0.310 | -0.1710 | Yes |
| 162 | Mgst3 | 20134 | -0.315 | -0.1658 | Yes |
| 163 | Hdgf | 20139 | -0.315 | -0.1573 | Yes |
| 164 | Slc6a9 | 20298 | -0.324 | -0.1551 | Yes |
| 165 | Mospd1 | 20367 | -0.328 | -0.1489 | Yes |
| 166 | Epor | 20383 | -0.329 | -0.1405 | Yes |
| 167 | Tent5c | 20638 | -0.344 | -0.1419 | Yes |
| 168 | Prdx2 | 21243 | -0.383 | -0.1571 | Yes |
| 169 | Arl2bp | 21461 | -0.399 | -0.1554 | Yes |
| 170 | Lmo2 | 21697 | -0.420 | -0.1538 | Yes |
| 171 | Glrx5 | 22015 | -0.448 | -0.1550 | Yes |
| 172 | Lrp10 | 22390 | -0.486 | -0.1576 | Yes |
| 173 | Rad23a | 22515 | -0.501 | -0.1491 | Yes |
| 174 | Epb42 | 22595 | -0.514 | -0.1383 | Yes |
| 175 | Asns | 22689 | -0.529 | -0.1277 | Yes |
| 176 | Acp5 | 22822 | -0.553 | -0.1181 | Yes |
| 177 | Urod | 22973 | -0.578 | -0.1086 | Yes |
| 178 | Car2 | 22979 | -0.579 | -0.0928 | Yes |
| 179 | Rap1gap | 23038 | -0.592 | -0.0790 | Yes |
| 180 | Pgls | 23074 | -0.599 | -0.0640 | Yes |
| 181 | Hebp1 | 23530 | -0.845 | -0.0601 | Yes |
| 182 | Pdzk1ip1 | 23532 | -0.848 | -0.0369 | Yes |
| 183 | Icam4 | 23621 | -1.479 | 0.0001 | Yes |

