| Dataset | CMP.CMP_Pheno.cls#Group3_versus_Group4.CMP_Pheno.cls#Group3_versus_Group4_repos |
| Phenotype | CMP_Pheno.cls#Group3_versus_Group4_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | 0.25065336 |
| Normalized Enrichment Score (NES) | 1.134393 |
| Nominal p-value | 0.3188119 |
| FDR q-value | 0.8153425 |
| FWER p-Value | 0.907 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Me1 | 0 | 2.144 | 0.0666 | Yes |
| 2 | Tmem97 | 420 | 0.623 | 0.0646 | Yes |
| 3 | Itgb2 | 473 | 0.608 | 0.0808 | Yes |
| 4 | Dhcr24 | 844 | 0.514 | 0.0779 | Yes |
| 5 | Sqle | 1079 | 0.472 | 0.0807 | Yes |
| 6 | Got1 | 1117 | 0.467 | 0.0933 | Yes |
| 7 | Map2k3 | 1133 | 0.466 | 0.1070 | Yes |
| 8 | Rdh11 | 1480 | 0.424 | 0.1025 | Yes |
| 9 | Bcat1 | 1539 | 0.417 | 0.1125 | Yes |
| 10 | Xbp1 | 1627 | 0.409 | 0.1208 | Yes |
| 11 | Ldlr | 1750 | 0.392 | 0.1267 | Yes |
| 12 | Insig1 | 1781 | 0.389 | 0.1373 | Yes |
| 13 | Ddx39a | 1957 | 0.372 | 0.1399 | Yes |
| 14 | Lgmn | 2059 | 0.363 | 0.1461 | Yes |
| 15 | Nufip1 | 2177 | 0.354 | 0.1511 | Yes |
| 16 | Psme3 | 2278 | 0.343 | 0.1566 | Yes |
| 17 | Fdxr | 2280 | 0.342 | 0.1672 | Yes |
| 18 | Cyp51 | 2657 | 0.315 | 0.1578 | Yes |
| 19 | Mthfd2l | 2791 | 0.304 | 0.1605 | Yes |
| 20 | Cct6a | 2818 | 0.303 | 0.1685 | Yes |
| 21 | Aurka | 2822 | 0.302 | 0.1778 | Yes |
| 22 | Aldoa | 2992 | 0.290 | 0.1782 | Yes |
| 23 | P4ha1 | 3040 | 0.284 | 0.1846 | Yes |
| 24 | Slc2a3 | 3103 | 0.279 | 0.1901 | Yes |
| 25 | Gpi1 | 3173 | 0.274 | 0.1951 | Yes |
| 26 | Cdkn1a | 3213 | 0.271 | 0.2015 | Yes |
| 27 | Etf1 | 3422 | 0.258 | 0.1989 | Yes |
| 28 | Sc5d | 3450 | 0.256 | 0.2055 | Yes |
| 29 | Pik3r3 | 3917 | 0.232 | 0.1889 | Yes |
| 30 | Coro1a | 3941 | 0.230 | 0.1949 | Yes |
| 31 | Slc1a4 | 3953 | 0.229 | 0.2015 | Yes |
| 32 | Atp2a2 | 4021 | 0.226 | 0.2051 | Yes |
| 33 | Atp6v1d | 4079 | 0.222 | 0.2091 | Yes |
| 34 | Gbe1 | 4093 | 0.221 | 0.2153 | Yes |
| 35 | Stip1 | 4120 | 0.220 | 0.2208 | Yes |
| 36 | Polr3g | 4125 | 0.220 | 0.2274 | Yes |
| 37 | Mcm2 | 4130 | 0.220 | 0.2340 | Yes |
| 38 | Mcm4 | 4280 | 0.211 | 0.2330 | Yes |
| 39 | Slc7a5 | 4398 | 0.207 | 0.2334 | Yes |
| 40 | Psmg1 | 4407 | 0.206 | 0.2394 | Yes |
| 41 | Ero1a | 4503 | 0.201 | 0.2408 | Yes |
| 42 | Hmgcs1 | 4551 | 0.198 | 0.2446 | Yes |
| 43 | Serpinh1 | 4554 | 0.198 | 0.2507 | Yes |
| 44 | Tm7sf2 | 4698 | 0.191 | 0.2493 | No |
| 45 | Arpc5l | 5103 | 0.170 | 0.2340 | No |
| 46 | Ufm1 | 5354 | 0.161 | 0.2262 | No |
| 47 | Ung | 5372 | 0.160 | 0.2303 | No |
| 48 | Shmt2 | 5642 | 0.148 | 0.2212 | No |
| 49 | Gtf2h1 | 5714 | 0.146 | 0.2221 | No |
| 50 | Ifi30 | 5724 | 0.145 | 0.2262 | No |
| 51 | Tuba4a | 5744 | 0.144 | 0.2297 | No |
| 52 | Fkbp2 | 5785 | 0.143 | 0.2321 | No |
| 53 | Cth | 5791 | 0.143 | 0.2363 | No |
| 54 | Ifrd1 | 6003 | 0.137 | 0.2298 | No |
| 55 | Ube2d3 | 6163 | 0.131 | 0.2257 | No |
| 56 | Gla | 6176 | 0.131 | 0.2292 | No |
| 57 | Psma3 | 6197 | 0.130 | 0.2322 | No |
| 58 | Psmd14 | 6211 | 0.129 | 0.2355 | No |
| 59 | Psph | 6228 | 0.129 | 0.2387 | No |
| 60 | Ctsc | 6282 | 0.127 | 0.2399 | No |
| 61 | Ak4 | 6456 | 0.120 | 0.2348 | No |
| 62 | Stard4 | 6542 | 0.116 | 0.2341 | No |
| 63 | Hspa9 | 6813 | 0.106 | 0.2236 | No |
| 64 | Add3 | 6815 | 0.106 | 0.2268 | No |
| 65 | Vldlr | 6862 | 0.104 | 0.2277 | No |
| 66 | Pdk1 | 6892 | 0.103 | 0.2294 | No |
| 67 | Hspe1 | 7017 | 0.099 | 0.2262 | No |
| 68 | Rrm2 | 7031 | 0.099 | 0.2286 | No |
| 69 | Calr | 7049 | 0.098 | 0.2308 | No |
| 70 | Cyb5b | 7148 | 0.094 | 0.2287 | No |
| 71 | Tpi1 | 7175 | 0.093 | 0.2302 | No |
| 72 | Nfyc | 7304 | 0.089 | 0.2264 | No |
| 73 | Nup205 | 7343 | 0.087 | 0.2272 | No |
| 74 | Hspd1 | 7371 | 0.086 | 0.2285 | No |
| 75 | Dhcr7 | 7384 | 0.086 | 0.2305 | No |
| 76 | Gclc | 7425 | 0.084 | 0.2311 | No |
| 77 | Actr3 | 7451 | 0.083 | 0.2324 | No |
| 78 | Slc2a1 | 7558 | 0.080 | 0.2295 | No |
| 79 | Tubg1 | 7602 | 0.078 | 0.2297 | No |
| 80 | Sdf2l1 | 7651 | 0.076 | 0.2297 | No |
| 81 | Gga2 | 7700 | 0.075 | 0.2295 | No |
| 82 | Slc37a4 | 7705 | 0.074 | 0.2316 | No |
| 83 | Gsk3b | 7725 | 0.073 | 0.2329 | No |
| 84 | Actr2 | 7952 | 0.066 | 0.2235 | No |
| 85 | Eno1b | 7959 | 0.066 | 0.2252 | No |
| 86 | Rpn1 | 7962 | 0.066 | 0.2271 | No |
| 87 | Pno1 | 8160 | 0.060 | 0.2189 | No |
| 88 | Ccnf | 8178 | 0.059 | 0.2199 | No |
| 89 | Immt | 8241 | 0.057 | 0.2185 | No |
| 90 | Pfkl | 8244 | 0.057 | 0.2201 | No |
| 91 | Phgdh | 8312 | 0.055 | 0.2184 | No |
| 92 | Uso1 | 8382 | 0.052 | 0.2165 | No |
| 93 | Cdc25a | 8445 | 0.050 | 0.2149 | No |
| 94 | Hspa4 | 8496 | 0.048 | 0.2138 | No |
| 95 | Ddit3 | 8583 | 0.045 | 0.2108 | No |
| 96 | Acly | 8639 | 0.043 | 0.2093 | No |
| 97 | Hmgcr | 8709 | 0.041 | 0.2071 | No |
| 98 | Lta4h | 8813 | 0.037 | 0.2030 | No |
| 99 | Wars1 | 8961 | 0.032 | 0.1965 | No |
| 100 | Txnrd1 | 9060 | 0.028 | 0.1924 | No |
| 101 | Cd9 | 9196 | 0.024 | 0.1862 | No |
| 102 | Nmt1 | 9464 | 0.016 | 0.1731 | No |
| 103 | Tcea1 | 9589 | 0.012 | 0.1671 | No |
| 104 | Skap2 | 9785 | 0.006 | 0.1573 | No |
| 105 | Hspa5 | 9908 | 0.001 | 0.1511 | No |
| 106 | Nfil3 | 9916 | 0.001 | 0.1508 | No |
| 107 | Tomm40 | 10074 | -0.000 | 0.1428 | No |
| 108 | Plk1 | 10107 | -0.001 | 0.1412 | No |
| 109 | Sord | 10325 | -0.008 | 0.1304 | No |
| 110 | Pgm1 | 10334 | -0.008 | 0.1302 | No |
| 111 | Slc6a6 | 10387 | -0.009 | 0.1278 | No |
| 112 | Idh1 | 10471 | -0.012 | 0.1240 | No |
| 113 | Hmbs | 10611 | -0.016 | 0.1174 | No |
| 114 | Ppp1r15a | 10659 | -0.018 | 0.1155 | No |
| 115 | Dapp1 | 10683 | -0.019 | 0.1150 | No |
| 116 | Cops5 | 10703 | -0.019 | 0.1146 | No |
| 117 | Niban1 | 10986 | -0.028 | 0.1011 | No |
| 118 | M6pr | 11007 | -0.029 | 0.1009 | No |
| 119 | Sqstm1 | 11102 | -0.032 | 0.0971 | No |
| 120 | Rpa1 | 11167 | -0.034 | 0.0949 | No |
| 121 | Uchl5 | 11188 | -0.035 | 0.0950 | No |
| 122 | Gmps | 11231 | -0.036 | 0.0940 | No |
| 123 | Elovl6 | 11288 | -0.038 | 0.0923 | No |
| 124 | Plod2 | 11367 | -0.040 | 0.0895 | No |
| 125 | Psmc6 | 11382 | -0.040 | 0.0901 | No |
| 126 | Psmb5 | 11425 | -0.042 | 0.0892 | No |
| 127 | Adipor2 | 11439 | -0.042 | 0.0899 | No |
| 128 | Asns | 11563 | -0.046 | 0.0850 | No |
| 129 | Tes | 11576 | -0.047 | 0.0859 | No |
| 130 | Serp1 | 11623 | -0.048 | 0.0850 | No |
| 131 | Srd5a1 | 11640 | -0.049 | 0.0857 | No |
| 132 | Psmd12 | 11668 | -0.050 | 0.0859 | No |
| 133 | Rit1 | 11915 | -0.058 | 0.0751 | No |
| 134 | Hk2 | 12009 | -0.061 | 0.0723 | No |
| 135 | Pdap1 | 12128 | -0.065 | 0.0682 | No |
| 136 | Cxcr4 | 12155 | -0.066 | 0.0689 | No |
| 137 | Rrp9 | 12366 | -0.070 | 0.0604 | No |
| 138 | Canx | 12396 | -0.071 | 0.0611 | No |
| 139 | Ppa1 | 12461 | -0.073 | 0.0601 | No |
| 140 | Rab1a | 12463 | -0.073 | 0.0624 | No |
| 141 | Nupr1 | 12526 | -0.075 | 0.0615 | No |
| 142 | Egln3 | 12609 | -0.077 | 0.0598 | No |
| 143 | Psat1 | 12652 | -0.079 | 0.0601 | No |
| 144 | Pitpnb | 12738 | -0.081 | 0.0582 | No |
| 145 | Elovl5 | 12741 | -0.082 | 0.0607 | No |
| 146 | Ldha | 12804 | -0.084 | 0.0601 | No |
| 147 | Tbk1 | 13053 | -0.093 | 0.0503 | No |
| 148 | Btg2 | 13115 | -0.095 | 0.0502 | No |
| 149 | Nampt | 13262 | -0.101 | 0.0458 | No |
| 150 | Cfp | 13332 | -0.103 | 0.0455 | No |
| 151 | Sec11a | 13628 | -0.114 | 0.0340 | No |
| 152 | Acaca | 13687 | -0.116 | 0.0346 | No |
| 153 | Eef1e1 | 13694 | -0.117 | 0.0380 | No |
| 154 | Ppia | 14039 | -0.129 | 0.0244 | No |
| 155 | Prdx1 | 14152 | -0.134 | 0.0229 | No |
| 156 | Mthfd2 | 14164 | -0.134 | 0.0265 | No |
| 157 | Dhfr | 14228 | -0.137 | 0.0275 | No |
| 158 | Sla | 14304 | -0.141 | 0.0281 | No |
| 159 | Abcf2 | 14333 | -0.141 | 0.0310 | No |
| 160 | Psmc2 | 14475 | -0.147 | 0.0284 | No |
| 161 | Psma4 | 14506 | -0.148 | 0.0315 | No |
| 162 | Nfkbib | 14526 | -0.149 | 0.0351 | No |
| 163 | Edem1 | 14572 | -0.151 | 0.0375 | No |
| 164 | Pgk1 | 14596 | -0.152 | 0.0410 | No |
| 165 | Idi1 | 14818 | -0.162 | 0.0348 | No |
| 166 | G6pdx | 14920 | -0.167 | 0.0348 | No |
| 167 | Psmd13 | 15134 | -0.173 | 0.0293 | No |
| 168 | Bhlhe40 | 15156 | -0.173 | 0.0336 | No |
| 169 | Bub1 | 15176 | -0.174 | 0.0381 | No |
| 170 | Ccng1 | 15237 | -0.176 | 0.0405 | No |
| 171 | Slc1a5 | 15351 | -0.181 | 0.0404 | No |
| 172 | Fads1 | 15378 | -0.183 | 0.0447 | No |
| 173 | Gsr | 15646 | -0.195 | 0.0371 | No |
| 174 | Ssr1 | 15752 | -0.200 | 0.0380 | No |
| 175 | Ddit4 | 15793 | -0.203 | 0.0422 | No |
| 176 | Mllt11 | 15872 | -0.207 | 0.0447 | No |
| 177 | Fads2 | 16042 | -0.215 | 0.0427 | No |
| 178 | Acsl3 | 16106 | -0.219 | 0.0463 | No |
| 179 | Eif2s2 | 16267 | -0.227 | 0.0452 | No |
| 180 | Ykt6 | 16392 | -0.233 | 0.0461 | No |
| 181 | Ebp | 16477 | -0.239 | 0.0493 | No |
| 182 | Trib3 | 16580 | -0.244 | 0.0516 | No |
| 183 | Hsp90b1 | 16682 | -0.252 | 0.0543 | No |
| 184 | Cacybp | 16694 | -0.253 | 0.0616 | No |
| 185 | Glrx | 16841 | -0.262 | 0.0623 | No |
| 186 | Fgl2 | 17372 | -0.297 | 0.0445 | No |
| 187 | Qdpr | 17404 | -0.299 | 0.0522 | No |
| 188 | Sytl2 | 18304 | -0.381 | 0.0181 | No |
| 189 | Psmc4 | 18664 | -0.420 | 0.0128 | No |
| 190 | Tfrc | 18666 | -0.420 | 0.0258 | No |
| 191 | Pnp | 18792 | -0.438 | 0.0330 | No |
| 192 | Slc7a11 | 19309 | -0.544 | 0.0236 | No |

