| Dataset | CMP.CMP_Pheno.cls#Group3_versus_Group4.CMP_Pheno.cls#Group3_versus_Group4_repos |
| Phenotype | CMP_Pheno.cls#Group3_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_E2F_TARGETS |
| Enrichment Score (ES) | -0.10998264 |
| Normalized Enrichment Score (NES) | -0.38535428 |
| Nominal p-value | 0.9882353 |
| FDR q-value | 0.9984336 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Shmt1 | 1164 | 0.462 | -0.0426 | No |
| 2 | Wdr90 | 1268 | 0.447 | -0.0314 | No |
| 3 | Ccp110 | 1623 | 0.410 | -0.0345 | No |
| 4 | Prdx4 | 1640 | 0.407 | -0.0204 | No |
| 5 | Ddx39a | 1957 | 0.372 | -0.0230 | No |
| 6 | Xrcc6 | 2222 | 0.349 | -0.0237 | No |
| 7 | Dscc1 | 2267 | 0.344 | -0.0133 | No |
| 8 | Stmn1 | 2408 | 0.332 | -0.0083 | No |
| 9 | Mcm5 | 2430 | 0.330 | 0.0027 | No |
| 10 | Spc25 | 2674 | 0.314 | 0.0018 | No |
| 11 | Kif2c | 2700 | 0.310 | 0.0119 | No |
| 12 | Gins4 | 2725 | 0.309 | 0.0220 | No |
| 13 | Aurka | 2822 | 0.302 | 0.0282 | No |
| 14 | Chek1 | 2874 | 0.298 | 0.0365 | No |
| 15 | Tubb5 | 2988 | 0.291 | 0.0413 | No |
| 16 | Cdkn2c | 3186 | 0.273 | 0.0413 | No |
| 17 | Donson | 3188 | 0.273 | 0.0512 | No |
| 18 | Cdkn1a | 3213 | 0.271 | 0.0599 | No |
| 19 | Nme1 | 3350 | 0.262 | 0.0625 | No |
| 20 | Pcna | 3646 | 0.244 | 0.0564 | No |
| 21 | Pms2 | 3826 | 0.237 | 0.0559 | No |
| 22 | Mcm2 | 4130 | 0.220 | 0.0485 | No |
| 23 | Tk1 | 4170 | 0.217 | 0.0544 | No |
| 24 | Timeless | 4246 | 0.213 | 0.0584 | No |
| 25 | Mcm4 | 4280 | 0.211 | 0.0645 | No |
| 26 | Cks2 | 4390 | 0.207 | 0.0665 | No |
| 27 | Nop56 | 4512 | 0.200 | 0.0676 | No |
| 28 | Hells | 4759 | 0.188 | 0.0619 | No |
| 29 | Orc6 | 4804 | 0.185 | 0.0665 | No |
| 30 | Pole | 4808 | 0.185 | 0.0731 | No |
| 31 | Ak2 | 5293 | 0.164 | 0.0544 | No |
| 32 | Ung | 5372 | 0.160 | 0.0563 | No |
| 33 | Rad1 | 5415 | 0.159 | 0.0599 | No |
| 34 | Wee1 | 5418 | 0.158 | 0.0656 | No |
| 35 | Ccnb2 | 5613 | 0.149 | 0.0612 | No |
| 36 | Kif18b | 5753 | 0.144 | 0.0594 | No |
| 37 | Lyar | 5805 | 0.142 | 0.0620 | No |
| 38 | Prim2 | 6117 | 0.133 | 0.0509 | No |
| 39 | Mcm6 | 6129 | 0.133 | 0.0552 | No |
| 40 | Espl1 | 6167 | 0.131 | 0.0581 | No |
| 41 | Paics | 6169 | 0.131 | 0.0629 | No |
| 42 | Racgap1 | 6185 | 0.130 | 0.0669 | No |
| 43 | Rad21 | 6271 | 0.127 | 0.0672 | No |
| 44 | Zw10 | 6277 | 0.127 | 0.0716 | No |
| 45 | Rad51ap1 | 6730 | 0.109 | 0.0525 | No |
| 46 | Ssrp1 | 6796 | 0.106 | 0.0531 | No |
| 47 | Myc | 6808 | 0.106 | 0.0564 | No |
| 48 | Ube2t | 6841 | 0.105 | 0.0586 | No |
| 49 | Gspt1 | 6856 | 0.104 | 0.0617 | No |
| 50 | Pds5b | 6867 | 0.104 | 0.0650 | No |
| 51 | Srsf2 | 6894 | 0.103 | 0.0674 | No |
| 52 | Rrm2 | 7031 | 0.099 | 0.0641 | No |
| 53 | Hnrnpd | 7072 | 0.097 | 0.0656 | No |
| 54 | Tra2b | 7151 | 0.094 | 0.0650 | No |
| 55 | Srsf1 | 7205 | 0.092 | 0.0657 | No |
| 56 | Rad51c | 7306 | 0.088 | 0.0638 | No |
| 57 | Nup205 | 7343 | 0.087 | 0.0652 | No |
| 58 | Rfc2 | 7540 | 0.080 | 0.0581 | No |
| 59 | Tubg1 | 7602 | 0.078 | 0.0578 | No |
| 60 | Cbx5 | 7607 | 0.078 | 0.0605 | No |
| 61 | Ccne1 | 7621 | 0.078 | 0.0627 | No |
| 62 | Tmpo | 7643 | 0.077 | 0.0644 | No |
| 63 | Gins3 | 7683 | 0.075 | 0.0652 | No |
| 64 | Xpo1 | 7849 | 0.070 | 0.0593 | No |
| 65 | Suv39h1 | 8023 | 0.064 | 0.0528 | No |
| 66 | Rbbp7 | 8115 | 0.061 | 0.0504 | No |
| 67 | Ipo7 | 8231 | 0.057 | 0.0466 | No |
| 68 | Rfc1 | 8271 | 0.056 | 0.0467 | No |
| 69 | Eed | 8279 | 0.056 | 0.0483 | No |
| 70 | Pola2 | 8395 | 0.052 | 0.0444 | No |
| 71 | Cdc25a | 8445 | 0.050 | 0.0437 | No |
| 72 | Ing3 | 8475 | 0.048 | 0.0440 | No |
| 73 | H2az1 | 8569 | 0.045 | 0.0409 | No |
| 74 | Mcm3 | 8708 | 0.041 | 0.0353 | No |
| 75 | Hmgb3 | 8747 | 0.040 | 0.0348 | No |
| 76 | Atad2 | 8756 | 0.039 | 0.0359 | No |
| 77 | Dlgap5 | 8791 | 0.038 | 0.0355 | No |
| 78 | Diaph3 | 8820 | 0.037 | 0.0355 | No |
| 79 | Nup153 | 8915 | 0.034 | 0.0319 | No |
| 80 | Pold1 | 8921 | 0.034 | 0.0329 | No |
| 81 | Lsm8 | 8932 | 0.033 | 0.0336 | No |
| 82 | Cnot9 | 8998 | 0.031 | 0.0314 | No |
| 83 | Smc1a | 9125 | 0.026 | 0.0259 | No |
| 84 | Ppp1r8 | 9350 | 0.019 | 0.0152 | No |
| 85 | Slbp | 9373 | 0.019 | 0.0147 | No |
| 86 | Lmnb1 | 9457 | 0.016 | 0.0111 | No |
| 87 | Psip1 | 9494 | 0.015 | 0.0098 | No |
| 88 | Ranbp1 | 9495 | 0.015 | 0.0104 | No |
| 89 | Asf1a | 9711 | 0.008 | -0.0003 | No |
| 90 | Nbn | 9728 | 0.007 | -0.0009 | No |
| 91 | Syncrip | 9854 | 0.003 | -0.0072 | No |
| 92 | Dctpp1 | 10085 | -0.001 | -0.0189 | No |
| 93 | Plk1 | 10107 | -0.001 | -0.0199 | No |
| 94 | Dut | 10244 | -0.005 | -0.0267 | No |
| 95 | Trp53 | 10324 | -0.008 | -0.0304 | No |
| 96 | Chek2 | 10388 | -0.009 | -0.0333 | No |
| 97 | Lbr | 10412 | -0.010 | -0.0341 | No |
| 98 | Cse1l | 10414 | -0.010 | -0.0338 | No |
| 99 | Mms22l | 10571 | -0.016 | -0.0412 | No |
| 100 | Eif2s1 | 10607 | -0.016 | -0.0424 | No |
| 101 | H2ax | 10644 | -0.018 | -0.0436 | No |
| 102 | Bard1 | 10717 | -0.020 | -0.0465 | No |
| 103 | Cdk4 | 10932 | -0.026 | -0.0565 | No |
| 104 | Snrpb | 10933 | -0.026 | -0.0555 | No |
| 105 | Nap1l1 | 10950 | -0.027 | -0.0553 | No |
| 106 | Ubr7 | 10968 | -0.027 | -0.0552 | No |
| 107 | Cdca3 | 11005 | -0.029 | -0.0560 | No |
| 108 | Mlh1 | 11015 | -0.029 | -0.0554 | No |
| 109 | Mki67 | 11138 | -0.033 | -0.0604 | No |
| 110 | Prkdc | 11143 | -0.033 | -0.0594 | No |
| 111 | Rpa1 | 11167 | -0.034 | -0.0593 | No |
| 112 | Cdk1 | 11177 | -0.034 | -0.0585 | No |
| 113 | Spag5 | 11299 | -0.038 | -0.0633 | No |
| 114 | Ube2s | 11348 | -0.039 | -0.0643 | No |
| 115 | Msh2 | 11366 | -0.040 | -0.0637 | No |
| 116 | Smc4 | 11380 | -0.040 | -0.0629 | No |
| 117 | Jpt1 | 11416 | -0.041 | -0.0632 | No |
| 118 | Aurkb | 11480 | -0.043 | -0.0648 | No |
| 119 | Nup107 | 11529 | -0.045 | -0.0656 | No |
| 120 | Ran | 11594 | -0.047 | -0.0671 | No |
| 121 | Mre11a | 11647 | -0.049 | -0.0680 | No |
| 122 | Pa2g4 | 11658 | -0.049 | -0.0667 | No |
| 123 | Top2a | 11738 | -0.052 | -0.0688 | No |
| 124 | Prps1 | 11756 | -0.053 | -0.0678 | No |
| 125 | Dclre1b | 11764 | -0.053 | -0.0662 | No |
| 126 | Dck | 11801 | -0.054 | -0.0661 | No |
| 127 | Nasp | 11845 | -0.055 | -0.0663 | No |
| 128 | Smc3 | 11850 | -0.055 | -0.0644 | No |
| 129 | Cdc25b | 11861 | -0.056 | -0.0629 | No |
| 130 | Mcm7 | 11890 | -0.057 | -0.0623 | No |
| 131 | Pole4 | 11909 | -0.058 | -0.0611 | No |
| 132 | Brca2 | 11965 | -0.060 | -0.0617 | No |
| 133 | Nolc1 | 12056 | -0.062 | -0.0640 | No |
| 134 | Cit | 12144 | -0.065 | -0.0661 | No |
| 135 | Tipin | 12229 | -0.068 | -0.0679 | No |
| 136 | Cenpe | 12263 | -0.069 | -0.0670 | No |
| 137 | Dek | 12354 | -0.070 | -0.0691 | No |
| 138 | Cks1b | 12403 | -0.072 | -0.0689 | No |
| 139 | Ctcf | 12424 | -0.072 | -0.0673 | No |
| 140 | Phf5a | 12454 | -0.073 | -0.0661 | No |
| 141 | Hmgb2 | 12587 | -0.077 | -0.0700 | No |
| 142 | Stag1 | 12619 | -0.078 | -0.0688 | No |
| 143 | Dnmt1 | 13024 | -0.092 | -0.0860 | No |
| 144 | Tacc3 | 13063 | -0.093 | -0.0846 | No |
| 145 | Ncapd2 | 13250 | -0.100 | -0.0904 | No |
| 146 | Cenpm | 13432 | -0.106 | -0.0957 | No |
| 147 | Ezh2 | 13712 | -0.118 | -0.1057 | Yes |
| 148 | Rad50 | 13715 | -0.118 | -0.1015 | Yes |
| 149 | Lig1 | 13728 | -0.118 | -0.0978 | Yes |
| 150 | Hmmr | 13823 | -0.121 | -0.0981 | Yes |
| 151 | E2f8 | 13873 | -0.123 | -0.0961 | Yes |
| 152 | Bub1b | 13937 | -0.126 | -0.0947 | Yes |
| 153 | Spc24 | 13940 | -0.126 | -0.0902 | Yes |
| 154 | Hus1 | 13960 | -0.127 | -0.0865 | Yes |
| 155 | Rfc3 | 14001 | -0.128 | -0.0839 | Yes |
| 156 | Luc7l3 | 14127 | -0.133 | -0.0854 | Yes |
| 157 | Mthfd2 | 14164 | -0.134 | -0.0823 | Yes |
| 158 | Orc2 | 14172 | -0.135 | -0.0778 | Yes |
| 159 | Birc5 | 14415 | -0.144 | -0.0848 | Yes |
| 160 | Mad2l1 | 14578 | -0.151 | -0.0876 | Yes |
| 161 | Pold2 | 14645 | -0.154 | -0.0853 | Yes |
| 162 | Tbrg4 | 14650 | -0.154 | -0.0799 | Yes |
| 163 | Anp32e | 14763 | -0.159 | -0.0797 | Yes |
| 164 | Usp1 | 14898 | -0.166 | -0.0805 | Yes |
| 165 | Pop7 | 14984 | -0.170 | -0.0786 | Yes |
| 166 | Ilf3 | 14989 | -0.170 | -0.0726 | Yes |
| 167 | Plk4 | 15021 | -0.171 | -0.0679 | Yes |
| 168 | Rpa3 | 15461 | -0.186 | -0.0835 | Yes |
| 169 | Pan2 | 15529 | -0.189 | -0.0800 | Yes |
| 170 | Pnn | 15613 | -0.193 | -0.0772 | Yes |
| 171 | Trip13 | 15697 | -0.197 | -0.0742 | Yes |
| 172 | Melk | 15759 | -0.201 | -0.0700 | Yes |
| 173 | Cdkn3 | 15805 | -0.203 | -0.0648 | Yes |
| 174 | Cdkn1b | 15818 | -0.204 | -0.0580 | Yes |
| 175 | Pold3 | 15905 | -0.208 | -0.0547 | Yes |
| 176 | Kif4 | 15935 | -0.210 | -0.0485 | Yes |
| 177 | Nudt21 | 15989 | -0.213 | -0.0435 | Yes |
| 178 | Rpa2 | 16060 | -0.216 | -0.0391 | Yes |
| 179 | Brca1 | 16123 | -0.220 | -0.0342 | Yes |
| 180 | Exosc8 | 16150 | -0.222 | -0.0274 | Yes |
| 181 | Mxd3 | 16258 | -0.226 | -0.0246 | Yes |
| 182 | Mybl2 | 16349 | -0.232 | -0.0207 | Yes |
| 183 | Cdkn2a | 16365 | -0.232 | -0.0130 | Yes |
| 184 | Gins1 | 16384 | -0.233 | -0.0054 | Yes |
| 185 | Hmga1b | 16524 | -0.242 | -0.0036 | Yes |
| 186 | Rnaseh2a | 16816 | -0.260 | -0.0090 | Yes |
| 187 | Psmc3ip | 16980 | -0.269 | -0.0074 | Yes |
| 188 | Kif22 | 17004 | -0.270 | 0.0013 | Yes |
| 189 | Depdc1a | 17070 | -0.276 | 0.0081 | Yes |
| 190 | Cdca8 | 17427 | -0.301 | 0.0009 | Yes |
| 191 | Smc6 | 17467 | -0.304 | 0.0101 | Yes |
| 192 | Cdc20 | 17784 | -0.326 | 0.0059 | Yes |
| 193 | Ppm1d | 18230 | -0.371 | -0.0033 | Yes |
| 194 | Tcf19 | 18249 | -0.374 | 0.0095 | Yes |
| 195 | Asf1b | 18601 | -0.411 | 0.0066 | Yes |
| 196 | Tfrc | 18666 | -0.420 | 0.0187 | Yes |
| 197 | Brms1l | 19136 | -0.500 | 0.0131 | Yes |
| 198 | Pttg1 | 19243 | -0.528 | 0.0270 | Yes |

