| Dataset | CMP.CMP_Pheno.cls#Group2_versus_Group4.CMP_Pheno.cls#Group2_versus_Group4_repos |
| Phenotype | CMP_Pheno.cls#Group2_versus_Group4_repos |
| Upregulated in class | 1 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | 0.42900103 |
| Normalized Enrichment Score (NES) | 1.6201402 |
| Nominal p-value | 0.044401545 |
| FDR q-value | 0.08369265 |
| FWER p-Value | 0.228 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Sqle | 119 | 0.830 | 0.0104 | Yes |
| 2 | Hspd1 | 128 | 0.823 | 0.0263 | Yes |
| 3 | Vldlr | 153 | 0.792 | 0.0407 | Yes |
| 4 | Hspa9 | 154 | 0.791 | 0.0564 | Yes |
| 5 | Aurka | 175 | 0.775 | 0.0708 | Yes |
| 6 | Stip1 | 250 | 0.727 | 0.0814 | Yes |
| 7 | Cyp51 | 281 | 0.711 | 0.0939 | Yes |
| 8 | Etf1 | 354 | 0.681 | 0.1038 | Yes |
| 9 | Canx | 410 | 0.661 | 0.1141 | Yes |
| 10 | Map2k3 | 416 | 0.659 | 0.1269 | Yes |
| 11 | Hspa4 | 461 | 0.643 | 0.1374 | Yes |
| 12 | Rrm2 | 488 | 0.632 | 0.1485 | Yes |
| 13 | Rpn1 | 674 | 0.581 | 0.1506 | Yes |
| 14 | Cct6a | 680 | 0.579 | 0.1618 | Yes |
| 15 | Bcat1 | 686 | 0.577 | 0.1730 | Yes |
| 16 | Xbp1 | 725 | 0.567 | 0.1823 | Yes |
| 17 | Hspe1 | 739 | 0.565 | 0.1929 | Yes |
| 18 | Hmgcr | 773 | 0.559 | 0.2022 | Yes |
| 19 | Mcm4 | 862 | 0.543 | 0.2085 | Yes |
| 20 | Gla | 909 | 0.536 | 0.2168 | Yes |
| 21 | Mcm2 | 983 | 0.522 | 0.2234 | Yes |
| 22 | Tpi1 | 990 | 0.519 | 0.2334 | Yes |
| 23 | Hmgcs1 | 1054 | 0.507 | 0.2402 | Yes |
| 24 | Serp1 | 1085 | 0.503 | 0.2486 | Yes |
| 25 | Me1 | 1208 | 0.488 | 0.2521 | Yes |
| 26 | Gpi1 | 1213 | 0.488 | 0.2615 | Yes |
| 27 | Ero1a | 1243 | 0.484 | 0.2697 | Yes |
| 28 | Txnrd1 | 1333 | 0.472 | 0.2745 | Yes |
| 29 | P4ha1 | 1617 | 0.443 | 0.2688 | Yes |
| 30 | Abcf2 | 1715 | 0.432 | 0.2724 | Yes |
| 31 | Cdc25a | 1834 | 0.418 | 0.2747 | Yes |
| 32 | Acsl3 | 1856 | 0.415 | 0.2818 | Yes |
| 33 | Ppia | 1899 | 0.411 | 0.2878 | Yes |
| 34 | Actr2 | 1903 | 0.410 | 0.2958 | Yes |
| 35 | Got1 | 2027 | 0.399 | 0.2974 | Yes |
| 36 | Hsp90b1 | 2134 | 0.387 | 0.2997 | Yes |
| 37 | Ykt6 | 2164 | 0.383 | 0.3058 | Yes |
| 38 | Nufip1 | 2252 | 0.377 | 0.3088 | Yes |
| 39 | Cdkn1a | 2287 | 0.374 | 0.3145 | Yes |
| 40 | Dhcr24 | 2350 | 0.368 | 0.3186 | Yes |
| 41 | Nup205 | 2355 | 0.368 | 0.3257 | Yes |
| 42 | Ccnf | 2371 | 0.366 | 0.3322 | Yes |
| 43 | Hspa5 | 2434 | 0.362 | 0.3362 | Yes |
| 44 | Insig1 | 2533 | 0.356 | 0.3382 | Yes |
| 45 | Fads1 | 2605 | 0.350 | 0.3416 | Yes |
| 46 | Psme3 | 2653 | 0.347 | 0.3460 | Yes |
| 47 | Stard4 | 2690 | 0.344 | 0.3510 | Yes |
| 48 | Pgm1 | 2798 | 0.338 | 0.3522 | Yes |
| 49 | Ddx39a | 2945 | 0.327 | 0.3513 | Yes |
| 50 | Atp2a2 | 2984 | 0.325 | 0.3558 | Yes |
| 51 | Calr | 2998 | 0.324 | 0.3615 | Yes |
| 52 | Acly | 3001 | 0.323 | 0.3678 | Yes |
| 53 | Bub1 | 3009 | 0.323 | 0.3739 | Yes |
| 54 | Ssr1 | 3023 | 0.322 | 0.3796 | Yes |
| 55 | Sc5d | 3052 | 0.320 | 0.3845 | Yes |
| 56 | Plk1 | 3084 | 0.319 | 0.3892 | Yes |
| 57 | Uso1 | 3148 | 0.316 | 0.3923 | Yes |
| 58 | Ufm1 | 3332 | 0.300 | 0.3889 | Yes |
| 59 | Ppa1 | 3371 | 0.297 | 0.3928 | Yes |
| 60 | Ifrd1 | 3433 | 0.296 | 0.3956 | Yes |
| 61 | Ube2d3 | 3465 | 0.293 | 0.3998 | Yes |
| 62 | Psph | 3474 | 0.292 | 0.4052 | Yes |
| 63 | Fgl2 | 3480 | 0.292 | 0.4107 | Yes |
| 64 | Psma3 | 3565 | 0.287 | 0.4121 | Yes |
| 65 | Pno1 | 3614 | 0.284 | 0.4153 | Yes |
| 66 | Ak4 | 3735 | 0.278 | 0.4147 | Yes |
| 67 | Shmt2 | 3744 | 0.278 | 0.4198 | Yes |
| 68 | Aldoa | 3765 | 0.276 | 0.4242 | Yes |
| 69 | Nfyc | 3917 | 0.266 | 0.4218 | Yes |
| 70 | Psmd14 | 3961 | 0.264 | 0.4248 | Yes |
| 71 | Pitpnb | 4054 | 0.257 | 0.4252 | Yes |
| 72 | Slc7a5 | 4156 | 0.250 | 0.4250 | Yes |
| 73 | Tfrc | 4236 | 0.244 | 0.4258 | Yes |
| 74 | Lgmn | 4502 | 0.229 | 0.4168 | Yes |
| 75 | Cyb5b | 4523 | 0.227 | 0.4203 | Yes |
| 76 | Actr3 | 4568 | 0.225 | 0.4225 | Yes |
| 77 | Rpa1 | 4703 | 0.218 | 0.4200 | Yes |
| 78 | Eif2s2 | 4742 | 0.215 | 0.4223 | Yes |
| 79 | Rab1a | 4766 | 0.214 | 0.4254 | Yes |
| 80 | Wars1 | 4927 | 0.205 | 0.4213 | Yes |
| 81 | Srd5a1 | 4989 | 0.202 | 0.4222 | Yes |
| 82 | Skap2 | 4998 | 0.201 | 0.4257 | Yes |
| 83 | Gmps | 5070 | 0.198 | 0.4260 | Yes |
| 84 | Pfkl | 5089 | 0.196 | 0.4290 | Yes |
| 85 | Gtf2h1 | 5275 | 0.189 | 0.4233 | No |
| 86 | Immt | 5479 | 0.179 | 0.4165 | No |
| 87 | Tm7sf2 | 5524 | 0.177 | 0.4177 | No |
| 88 | Polr3g | 5578 | 0.174 | 0.4185 | No |
| 89 | Psmc6 | 5630 | 0.171 | 0.4193 | No |
| 90 | Itgb2 | 5644 | 0.170 | 0.4220 | No |
| 91 | Uchl5 | 5773 | 0.166 | 0.4187 | No |
| 92 | Bhlhe40 | 5783 | 0.166 | 0.4216 | No |
| 93 | Sord | 5929 | 0.159 | 0.4173 | No |
| 94 | Pnp | 6042 | 0.153 | 0.4146 | No |
| 95 | Gga2 | 6165 | 0.146 | 0.4113 | No |
| 96 | Nupr1 | 6389 | 0.136 | 0.4026 | No |
| 97 | Ctsc | 6603 | 0.127 | 0.3942 | No |
| 98 | Gsk3b | 6622 | 0.126 | 0.3958 | No |
| 99 | Nmt1 | 6655 | 0.124 | 0.3966 | No |
| 100 | Pdap1 | 6721 | 0.120 | 0.3957 | No |
| 101 | Ldlr | 6758 | 0.119 | 0.3962 | No |
| 102 | Pgk1 | 6761 | 0.119 | 0.3984 | No |
| 103 | Pdk1 | 6830 | 0.115 | 0.3972 | No |
| 104 | Mthfd2l | 6889 | 0.112 | 0.3965 | No |
| 105 | Elovl5 | 6972 | 0.108 | 0.3945 | No |
| 106 | M6pr | 7030 | 0.105 | 0.3936 | No |
| 107 | Psat1 | 7135 | 0.101 | 0.3903 | No |
| 108 | Psmc4 | 7168 | 0.099 | 0.3907 | No |
| 109 | Tmem97 | 7231 | 0.097 | 0.3894 | No |
| 110 | Asns | 7294 | 0.093 | 0.3881 | No |
| 111 | Elovl6 | 7320 | 0.092 | 0.3887 | No |
| 112 | Ifi30 | 7411 | 0.088 | 0.3858 | No |
| 113 | Trib3 | 7443 | 0.087 | 0.3859 | No |
| 114 | Psmb5 | 7445 | 0.087 | 0.3876 | No |
| 115 | Coro1a | 7479 | 0.085 | 0.3876 | No |
| 116 | Idh1 | 7705 | 0.075 | 0.3776 | No |
| 117 | Psmg1 | 7730 | 0.074 | 0.3779 | No |
| 118 | Rrp9 | 7792 | 0.072 | 0.3762 | No |
| 119 | Fdxr | 7795 | 0.071 | 0.3775 | No |
| 120 | Prdx1 | 7835 | 0.070 | 0.3769 | No |
| 121 | Psmd12 | 7883 | 0.068 | 0.3758 | No |
| 122 | Rdh11 | 8265 | 0.050 | 0.3573 | No |
| 123 | Hk2 | 8451 | 0.042 | 0.3487 | No |
| 124 | Add3 | 8493 | 0.040 | 0.3474 | No |
| 125 | Hmbs | 8572 | 0.036 | 0.3442 | No |
| 126 | Ung | 8579 | 0.036 | 0.3446 | No |
| 127 | Slc6a6 | 8924 | 0.022 | 0.3275 | No |
| 128 | Atp6v1d | 8958 | 0.021 | 0.3262 | No |
| 129 | Serpinh1 | 9061 | 0.017 | 0.3213 | No |
| 130 | Acaca | 9102 | 0.015 | 0.3196 | No |
| 131 | Mthfd2 | 9109 | 0.015 | 0.3196 | No |
| 132 | Ddit4 | 9280 | 0.008 | 0.3110 | No |
| 133 | Tubg1 | 9354 | 0.005 | 0.3074 | No |
| 134 | Nampt | 9468 | 0.001 | 0.3016 | No |
| 135 | Slc1a5 | 9647 | -0.004 | 0.2926 | No |
| 136 | Tcea1 | 9738 | -0.008 | 0.2882 | No |
| 137 | Lta4h | 9970 | -0.018 | 0.2767 | No |
| 138 | Slc1a4 | 9986 | -0.018 | 0.2763 | No |
| 139 | Slc2a3 | 10119 | -0.024 | 0.2701 | No |
| 140 | Dhcr7 | 10194 | -0.027 | 0.2668 | No |
| 141 | Cacybp | 10496 | -0.040 | 0.2522 | No |
| 142 | Qdpr | 10535 | -0.042 | 0.2511 | No |
| 143 | Tes | 10775 | -0.051 | 0.2399 | No |
| 144 | Adipor2 | 10841 | -0.054 | 0.2377 | No |
| 145 | Tbk1 | 11032 | -0.063 | 0.2292 | No |
| 146 | Dhfr | 11176 | -0.067 | 0.2232 | No |
| 147 | Phgdh | 11390 | -0.075 | 0.2138 | No |
| 148 | Slc37a4 | 11433 | -0.077 | 0.2132 | No |
| 149 | Edem1 | 11436 | -0.077 | 0.2146 | No |
| 150 | Psmc2 | 11569 | -0.084 | 0.2095 | No |
| 151 | Fads2 | 11946 | -0.099 | 0.1923 | No |
| 152 | Idi1 | 12191 | -0.110 | 0.1820 | No |
| 153 | Plod2 | 12437 | -0.121 | 0.1719 | No |
| 154 | Gsr | 12449 | -0.121 | 0.1738 | No |
| 155 | Sytl2 | 12618 | -0.129 | 0.1677 | No |
| 156 | Pik3r3 | 12629 | -0.129 | 0.1698 | No |
| 157 | Nfil3 | 12834 | -0.138 | 0.1621 | No |
| 158 | Gclc | 13134 | -0.150 | 0.1498 | No |
| 159 | Eno1b | 13150 | -0.151 | 0.1520 | No |
| 160 | Fkbp2 | 13240 | -0.155 | 0.1506 | No |
| 161 | Sqstm1 | 13368 | -0.160 | 0.1472 | No |
| 162 | Arpc5l | 13686 | -0.175 | 0.1345 | No |
| 163 | Egln3 | 13702 | -0.175 | 0.1372 | No |
| 164 | Psma4 | 13773 | -0.178 | 0.1372 | No |
| 165 | Cops5 | 14125 | -0.194 | 0.1231 | No |
| 166 | Sla | 14169 | -0.196 | 0.1248 | No |
| 167 | Tuba4a | 14229 | -0.199 | 0.1257 | No |
| 168 | Niban1 | 14272 | -0.201 | 0.1276 | No |
| 169 | Tomm40 | 14311 | -0.203 | 0.1296 | No |
| 170 | Ldha | 14330 | -0.204 | 0.1328 | No |
| 171 | Slc7a11 | 14390 | -0.206 | 0.1338 | No |
| 172 | G6pdx | 14582 | -0.216 | 0.1284 | No |
| 173 | Cth | 14727 | -0.223 | 0.1254 | No |
| 174 | Sdf2l1 | 14754 | -0.224 | 0.1285 | No |
| 175 | Slc2a1 | 15050 | -0.239 | 0.1182 | No |
| 176 | Sec11a | 15239 | -0.249 | 0.1136 | No |
| 177 | Rit1 | 15493 | -0.262 | 0.1058 | No |
| 178 | Ccng1 | 15719 | -0.274 | 0.0998 | No |
| 179 | Ddit3 | 15804 | -0.279 | 0.1010 | No |
| 180 | Psmd13 | 15972 | -0.288 | 0.0982 | No |
| 181 | Cxcr4 | 16010 | -0.291 | 0.1020 | No |
| 182 | Gbe1 | 16053 | -0.293 | 0.1057 | No |
| 183 | Ppp1r15a | 16352 | -0.311 | 0.0967 | No |
| 184 | Glrx | 16476 | -0.320 | 0.0967 | No |
| 185 | Dapp1 | 16822 | -0.343 | 0.0859 | No |
| 186 | Btg2 | 16851 | -0.346 | 0.0913 | No |
| 187 | Nfkbib | 17179 | -0.368 | 0.0819 | No |
| 188 | Cfp | 18301 | -0.471 | 0.0340 | No |
| 189 | Mllt11 | 18316 | -0.474 | 0.0427 | No |
| 190 | Cd9 | 18571 | -0.507 | 0.0398 | No |
| 191 | Ebp | 18763 | -0.535 | 0.0406 | No |
| 192 | Eef1e1 | 18821 | -0.545 | 0.0485 | No |

