| Dataset | CMP.CMP_Pheno.cls#Group2_versus_Group3.CMP_Pheno.cls#Group2_versus_Group3_repos |
| Phenotype | CMP_Pheno.cls#Group2_versus_Group3_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_P53_PATHWAY |
| Enrichment Score (ES) | -0.18999895 |
| Normalized Enrichment Score (NES) | -0.79572916 |
| Nominal p-value | 0.77663934 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Slc35d1 | 332 | 0.633 | -0.0014 | No |
| 2 | Atf3 | 389 | 0.608 | 0.0106 | No |
| 3 | Aen | 630 | 0.539 | 0.0116 | No |
| 4 | Rhbdf2 | 643 | 0.538 | 0.0242 | No |
| 5 | Tgfa | 766 | 0.514 | 0.0306 | No |
| 6 | H2ac25 | 816 | 0.502 | 0.0404 | No |
| 7 | App | 1169 | 0.449 | 0.0334 | No |
| 8 | Slc7a11 | 1347 | 0.430 | 0.0349 | No |
| 9 | Acvr1b | 1592 | 0.397 | 0.0322 | No |
| 10 | Trafd1 | 1796 | 0.376 | 0.0311 | No |
| 11 | Tnfsf9 | 1889 | 0.367 | 0.0354 | No |
| 12 | Trib3 | 1918 | 0.365 | 0.0429 | No |
| 13 | Tax1bp3 | 2021 | 0.356 | 0.0465 | No |
| 14 | Apaf1 | 2029 | 0.356 | 0.0548 | No |
| 15 | Ccp110 | 2084 | 0.351 | 0.0607 | No |
| 16 | Zmat3 | 2316 | 0.334 | 0.0571 | No |
| 17 | Fos | 2334 | 0.334 | 0.0644 | No |
| 18 | Polh | 2379 | 0.330 | 0.0703 | No |
| 19 | Cdkn2aip | 2440 | 0.326 | 0.0752 | No |
| 20 | Lif | 2528 | 0.319 | 0.0786 | No |
| 21 | Ada | 2587 | 0.317 | 0.0834 | No |
| 22 | Foxo3 | 2630 | 0.314 | 0.0890 | No |
| 23 | Hspa4l | 2649 | 0.312 | 0.0957 | No |
| 24 | Prmt2 | 2659 | 0.311 | 0.1029 | No |
| 25 | Elp1 | 2692 | 0.309 | 0.1088 | No |
| 26 | Rap2b | 2868 | 0.296 | 0.1071 | No |
| 27 | Rxra | 2890 | 0.296 | 0.1133 | No |
| 28 | S100a4 | 2959 | 0.290 | 0.1170 | No |
| 29 | Zfp365 | 3333 | 0.268 | 0.1045 | No |
| 30 | Tchh | 3366 | 0.265 | 0.1094 | No |
| 31 | Hexim1 | 3453 | 0.261 | 0.1114 | No |
| 32 | Fas | 3637 | 0.250 | 0.1081 | No |
| 33 | Pdgfa | 3806 | 0.239 | 0.1054 | No |
| 34 | Cdh13 | 3916 | 0.233 | 0.1056 | No |
| 35 | H2aj | 4269 | 0.215 | 0.0929 | No |
| 36 | Nupr1 | 4344 | 0.210 | 0.0942 | No |
| 37 | H1f2 | 4654 | 0.194 | 0.0832 | No |
| 38 | Baiap2 | 4687 | 0.193 | 0.0863 | No |
| 39 | Sphk1 | 4877 | 0.184 | 0.0812 | No |
| 40 | Rab40c | 5064 | 0.176 | 0.0760 | No |
| 41 | Ddit4 | 5417 | 0.158 | 0.0619 | No |
| 42 | Ddb2 | 5590 | 0.149 | 0.0568 | No |
| 43 | Hmox1 | 5639 | 0.147 | 0.0579 | No |
| 44 | Sp1 | 5718 | 0.144 | 0.0575 | No |
| 45 | Dgka | 5756 | 0.142 | 0.0591 | No |
| 46 | Ptpn14 | 5771 | 0.141 | 0.0618 | No |
| 47 | Cdkn2a | 5867 | 0.139 | 0.0604 | No |
| 48 | Tspyl2 | 5886 | 0.139 | 0.0629 | No |
| 49 | Sat1 | 5933 | 0.136 | 0.0639 | No |
| 50 | Epha2 | 5970 | 0.135 | 0.0653 | No |
| 51 | Plk3 | 5983 | 0.134 | 0.0680 | No |
| 52 | Stom | 6020 | 0.133 | 0.0694 | No |
| 53 | Procr | 6295 | 0.120 | 0.0584 | No |
| 54 | Ppm1d | 6349 | 0.118 | 0.0586 | No |
| 55 | Tap1 | 6403 | 0.115 | 0.0587 | No |
| 56 | Pvt1 | 6484 | 0.112 | 0.0574 | No |
| 57 | Hras | 6585 | 0.108 | 0.0549 | No |
| 58 | Plxnb2 | 6608 | 0.107 | 0.0564 | No |
| 59 | Cdkn1a | 6987 | 0.092 | 0.0393 | No |
| 60 | Ercc5 | 7080 | 0.087 | 0.0368 | No |
| 61 | Eps8l2 | 7108 | 0.086 | 0.0375 | No |
| 62 | Mdm2 | 7204 | 0.082 | 0.0347 | No |
| 63 | Vdr | 7308 | 0.077 | 0.0313 | No |
| 64 | Mapkapk3 | 7503 | 0.068 | 0.0231 | No |
| 65 | Nol8 | 7795 | 0.057 | 0.0096 | No |
| 66 | Wwp1 | 7800 | 0.057 | 0.0108 | No |
| 67 | Pmm1 | 7829 | 0.056 | 0.0107 | No |
| 68 | Rnf19b | 7949 | 0.051 | 0.0059 | No |
| 69 | Ier5 | 8031 | 0.048 | 0.0029 | No |
| 70 | Sec61a1 | 8051 | 0.046 | 0.0031 | No |
| 71 | Rad51c | 8127 | 0.043 | 0.0003 | No |
| 72 | Triap1 | 8231 | 0.039 | -0.0040 | No |
| 73 | Upp1 | 8277 | 0.037 | -0.0054 | No |
| 74 | Hint1 | 8341 | 0.034 | -0.0078 | No |
| 75 | Rrp8 | 8474 | 0.029 | -0.0138 | No |
| 76 | Ak1 | 8509 | 0.027 | -0.0149 | No |
| 77 | Mknk2 | 8779 | 0.016 | -0.0282 | No |
| 78 | F2r | 8782 | 0.016 | -0.0279 | No |
| 79 | Dcxr | 8812 | 0.015 | -0.0291 | No |
| 80 | Plk2 | 8857 | 0.013 | -0.0310 | No |
| 81 | Hbegf | 8892 | 0.011 | -0.0324 | No |
| 82 | Dnttip2 | 8930 | 0.010 | -0.0341 | No |
| 83 | Vwa5a | 8979 | 0.009 | -0.0363 | No |
| 84 | Traf4 | 9156 | 0.003 | -0.0452 | No |
| 85 | Casp1 | 9300 | -0.000 | -0.0525 | No |
| 86 | Abcc5 | 9302 | -0.001 | -0.0526 | No |
| 87 | Ip6k2 | 9463 | -0.005 | -0.0606 | No |
| 88 | Ei24 | 9550 | -0.009 | -0.0648 | No |
| 89 | Jag2 | 9650 | -0.013 | -0.0695 | No |
| 90 | Fbxw7 | 9694 | -0.015 | -0.0714 | No |
| 91 | Nudt15 | 9794 | -0.018 | -0.0760 | No |
| 92 | Kif13b | 9878 | -0.022 | -0.0797 | No |
| 93 | Sfn | 9895 | -0.022 | -0.0799 | No |
| 94 | Sdc1 | 9902 | -0.023 | -0.0797 | No |
| 95 | Tob1 | 9991 | -0.027 | -0.0835 | No |
| 96 | Vamp8 | 10085 | -0.031 | -0.0875 | No |
| 97 | Cyfip2 | 10145 | -0.033 | -0.0897 | No |
| 98 | Trp53 | 10188 | -0.035 | -0.0910 | No |
| 99 | Socs1 | 10222 | -0.036 | -0.0918 | No |
| 100 | Pcna | 10243 | -0.037 | -0.0919 | No |
| 101 | Bax | 10305 | -0.039 | -0.0941 | No |
| 102 | Ralgds | 10413 | -0.043 | -0.0985 | No |
| 103 | Klf4 | 10516 | -0.047 | -0.1025 | No |
| 104 | Ccnk | 10559 | -0.049 | -0.1035 | No |
| 105 | Xpc | 10569 | -0.049 | -0.1027 | No |
| 106 | Zfp36l1 | 10641 | -0.053 | -0.1051 | No |
| 107 | Cdk5r1 | 10871 | -0.062 | -0.1152 | No |
| 108 | Klk8 | 10927 | -0.065 | -0.1164 | No |
| 109 | Ctsd | 11005 | -0.068 | -0.1187 | No |
| 110 | Prkab1 | 11137 | -0.075 | -0.1236 | No |
| 111 | Rb1 | 11388 | -0.085 | -0.1342 | No |
| 112 | Ccng1 | 11502 | -0.090 | -0.1378 | No |
| 113 | Rpl18 | 11505 | -0.090 | -0.1357 | No |
| 114 | Rad9a | 11548 | -0.092 | -0.1356 | No |
| 115 | Ifi30 | 11560 | -0.092 | -0.1339 | No |
| 116 | S100a10 | 11784 | -0.100 | -0.1428 | No |
| 117 | Jun | 12141 | -0.116 | -0.1582 | No |
| 118 | Rps27l | 12294 | -0.121 | -0.1630 | No |
| 119 | Ccnd3 | 12630 | -0.134 | -0.1768 | No |
| 120 | Fam162a | 12677 | -0.135 | -0.1758 | No |
| 121 | Itgb4 | 12868 | -0.142 | -0.1820 | No |
| 122 | Sesn1 | 12911 | -0.145 | -0.1806 | No |
| 123 | Pom121 | 12943 | -0.146 | -0.1786 | No |
| 124 | Tsc22d1 | 12953 | -0.146 | -0.1755 | No |
| 125 | Txnip | 12978 | -0.147 | -0.1731 | No |
| 126 | Csrnp2 | 12984 | -0.147 | -0.1697 | No |
| 127 | St14 | 13204 | -0.157 | -0.1771 | No |
| 128 | Cd82 | 13213 | -0.157 | -0.1736 | No |
| 129 | Ier3 | 13274 | -0.160 | -0.1728 | No |
| 130 | Rpl36 | 13350 | -0.164 | -0.1726 | No |
| 131 | Slc3a2 | 13440 | -0.168 | -0.1730 | No |
| 132 | Irag2 | 13479 | -0.169 | -0.1708 | No |
| 133 | Hdac3 | 13533 | -0.172 | -0.1693 | No |
| 134 | Abat | 13592 | -0.175 | -0.1680 | No |
| 135 | Sertad3 | 13671 | -0.178 | -0.1676 | No |
| 136 | Slc19a2 | 13702 | -0.179 | -0.1647 | No |
| 137 | Wrap73 | 13775 | -0.181 | -0.1640 | No |
| 138 | Btg1 | 13884 | -0.186 | -0.1649 | No |
| 139 | Cebpa | 14019 | -0.192 | -0.1670 | No |
| 140 | Pidd1 | 14052 | -0.194 | -0.1639 | No |
| 141 | Bak1 | 14076 | -0.196 | -0.1603 | No |
| 142 | Trp63 | 14393 | -0.210 | -0.1713 | No |
| 143 | Ninj1 | 14585 | -0.220 | -0.1756 | No |
| 144 | Gls2 | 14620 | -0.222 | -0.1719 | No |
| 145 | Steap3 | 14746 | -0.229 | -0.1727 | No |
| 146 | Notch1 | 14881 | -0.236 | -0.1737 | No |
| 147 | Def6 | 14923 | -0.237 | -0.1700 | No |
| 148 | Rps12 | 14968 | -0.240 | -0.1663 | No |
| 149 | Tm7sf3 | 15363 | -0.261 | -0.1801 | No |
| 150 | Btg2 | 15370 | -0.261 | -0.1740 | No |
| 151 | Zbtb16 | 15685 | -0.277 | -0.1832 | Yes |
| 152 | Ndrg1 | 15797 | -0.283 | -0.1819 | Yes |
| 153 | Fdxr | 15886 | -0.290 | -0.1793 | Yes |
| 154 | Blcap | 15899 | -0.290 | -0.1728 | Yes |
| 155 | Coq8a | 15953 | -0.293 | -0.1683 | Yes |
| 156 | Tpd52l1 | 15973 | -0.295 | -0.1621 | Yes |
| 157 | Ctsf | 16156 | -0.305 | -0.1639 | Yes |
| 158 | Irak1 | 16306 | -0.314 | -0.1638 | Yes |
| 159 | Mxd4 | 16334 | -0.316 | -0.1574 | Yes |
| 160 | Ccnd2 | 16411 | -0.321 | -0.1534 | Yes |
| 161 | Rchy1 | 16440 | -0.323 | -0.1469 | Yes |
| 162 | Rrad | 16480 | -0.326 | -0.1409 | Yes |
| 163 | Tgfb1 | 16886 | -0.350 | -0.1530 | Yes |
| 164 | Cgrrf1 | 16959 | -0.355 | -0.1480 | Yes |
| 165 | Iscu | 17063 | -0.363 | -0.1444 | Yes |
| 166 | Ddit3 | 17097 | -0.365 | -0.1371 | Yes |
| 167 | Ppp1r15a | 17115 | -0.366 | -0.1290 | Yes |
| 168 | Ldhb | 17133 | -0.367 | -0.1208 | Yes |
| 169 | Gadd45a | 17135 | -0.368 | -0.1119 | Yes |
| 170 | Retsat | 17295 | -0.380 | -0.1106 | Yes |
| 171 | Ptpre | 17472 | -0.396 | -0.1099 | Yes |
| 172 | Perp | 17525 | -0.400 | -0.1028 | Yes |
| 173 | Gm2a | 17533 | -0.400 | -0.0933 | Yes |
| 174 | Ankra2 | 17586 | -0.405 | -0.0860 | Yes |
| 175 | Rack1 | 17888 | -0.432 | -0.0908 | Yes |
| 176 | Fgf13 | 17965 | -0.440 | -0.0839 | Yes |
| 177 | Dram1 | 18157 | -0.461 | -0.0824 | Yes |
| 178 | Pitpnc1 | 18373 | -0.490 | -0.0813 | Yes |
| 179 | Phlda3 | 18414 | -0.495 | -0.0712 | Yes |
| 180 | Cd81 | 18587 | -0.520 | -0.0673 | Yes |
| 181 | Fuca1 | 18607 | -0.522 | -0.0554 | Yes |
| 182 | Tcn2 | 18946 | -0.587 | -0.0583 | Yes |
| 183 | Tprkb | 19068 | -0.612 | -0.0495 | Yes |
| 184 | Alox8 | 19148 | -0.631 | -0.0380 | Yes |
| 185 | Osgin1 | 19182 | -0.639 | -0.0240 | Yes |
| 186 | Ephx1 | 19219 | -0.650 | -0.0099 | Yes |
| 187 | Mxd1 | 19313 | -0.682 | 0.0021 | Yes |
| 188 | Abhd4 | 19621 | -0.867 | 0.0077 | Yes |

