| Dataset | CMP.CMP_Pheno.cls#Group2_versus_Group3.CMP_Pheno.cls#Group2_versus_Group3_repos |
| Phenotype | CMP_Pheno.cls#Group2_versus_Group3_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_HYPOXIA |
| Enrichment Score (ES) | -0.18154432 |
| Normalized Enrichment Score (NES) | -0.77877754 |
| Nominal p-value | 0.88958335 |
| FDR q-value | 0.9251836 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Gpc3 | 158 | 0.739 | 0.0104 | No |
| 2 | Cavin1 | 178 | 0.720 | 0.0274 | No |
| 3 | Pim1 | 229 | 0.686 | 0.0420 | No |
| 4 | Tgm2 | 329 | 0.633 | 0.0528 | No |
| 5 | Atf3 | 389 | 0.608 | 0.0650 | No |
| 6 | Bhlhe40 | 437 | 0.591 | 0.0774 | No |
| 7 | Anxa2 | 932 | 0.483 | 0.0642 | No |
| 8 | Vldlr | 968 | 0.477 | 0.0744 | No |
| 9 | Kif5a | 975 | 0.475 | 0.0859 | No |
| 10 | Hdlbp | 1196 | 0.447 | 0.0859 | No |
| 11 | Tgfbi | 1298 | 0.434 | 0.0916 | No |
| 12 | Plin2 | 1631 | 0.393 | 0.0845 | No |
| 13 | Tgfb3 | 1868 | 0.369 | 0.0816 | No |
| 14 | Pgm1 | 2167 | 0.346 | 0.0751 | No |
| 15 | Cdkn1b | 2204 | 0.343 | 0.0818 | No |
| 16 | Fos | 2334 | 0.334 | 0.0836 | No |
| 17 | Tpi1 | 2381 | 0.330 | 0.0895 | No |
| 18 | Sap30 | 2386 | 0.330 | 0.0975 | No |
| 19 | Hspa5 | 2387 | 0.330 | 0.1057 | No |
| 20 | Jmjd6 | 2415 | 0.328 | 0.1126 | No |
| 21 | Foxo3 | 2630 | 0.314 | 0.1095 | No |
| 22 | Pgk1 | 2719 | 0.307 | 0.1127 | No |
| 23 | Cp | 2744 | 0.305 | 0.1191 | No |
| 24 | Ets1 | 2747 | 0.304 | 0.1266 | No |
| 25 | Hk1 | 2844 | 0.298 | 0.1291 | No |
| 26 | S100a4 | 2959 | 0.290 | 0.1306 | No |
| 27 | Ero1a | 3034 | 0.285 | 0.1339 | No |
| 28 | Sdc3 | 3105 | 0.281 | 0.1374 | No |
| 29 | Phkg1 | 3259 | 0.273 | 0.1364 | No |
| 30 | Pfkp | 3422 | 0.262 | 0.1347 | No |
| 31 | Rragd | 3700 | 0.247 | 0.1267 | No |
| 32 | Col5a1 | 3788 | 0.241 | 0.1283 | No |
| 33 | Grhpr | 3818 | 0.238 | 0.1328 | No |
| 34 | Gapdhs | 3832 | 0.238 | 0.1381 | No |
| 35 | Myh9 | 4083 | 0.223 | 0.1309 | No |
| 36 | Dusp1 | 4239 | 0.217 | 0.1284 | No |
| 37 | Gpi1 | 4260 | 0.216 | 0.1328 | No |
| 38 | Vegfa | 4493 | 0.202 | 0.1260 | No |
| 39 | Ak4 | 4712 | 0.191 | 0.1196 | No |
| 40 | Lxn | 4742 | 0.190 | 0.1229 | No |
| 41 | Ndst1 | 4756 | 0.189 | 0.1270 | No |
| 42 | Ids | 4976 | 0.180 | 0.1203 | No |
| 43 | Stbd1 | 5174 | 0.170 | 0.1145 | No |
| 44 | Mxi1 | 5378 | 0.160 | 0.1081 | No |
| 45 | Ddit4 | 5417 | 0.158 | 0.1101 | No |
| 46 | Isg20 | 5439 | 0.157 | 0.1130 | No |
| 47 | Nr3c1 | 5452 | 0.156 | 0.1163 | No |
| 48 | Hmox1 | 5639 | 0.147 | 0.1104 | No |
| 49 | Errfi1 | 5827 | 0.141 | 0.1044 | No |
| 50 | Mt1 | 5835 | 0.140 | 0.1076 | No |
| 51 | Pfkl | 5847 | 0.140 | 0.1105 | No |
| 52 | P4ha1 | 5858 | 0.139 | 0.1135 | No |
| 53 | Car12 | 6162 | 0.126 | 0.1012 | No |
| 54 | Maff | 6376 | 0.117 | 0.0932 | No |
| 55 | Adora2b | 6430 | 0.114 | 0.0934 | No |
| 56 | Tpd52 | 6524 | 0.110 | 0.0914 | No |
| 57 | Tiparp | 6830 | 0.099 | 0.0783 | No |
| 58 | Cdkn1a | 6987 | 0.092 | 0.0726 | No |
| 59 | Hk2 | 7003 | 0.091 | 0.0741 | No |
| 60 | Rora | 7258 | 0.079 | 0.0632 | No |
| 61 | Zfp36 | 7363 | 0.074 | 0.0597 | No |
| 62 | Ugp2 | 7408 | 0.072 | 0.0593 | No |
| 63 | Pnrc1 | 7442 | 0.071 | 0.0594 | No |
| 64 | Pgm2 | 7901 | 0.053 | 0.0374 | No |
| 65 | Hexa | 7959 | 0.050 | 0.0357 | No |
| 66 | Kdm3a | 7991 | 0.049 | 0.0354 | No |
| 67 | Siah2 | 8083 | 0.045 | 0.0318 | No |
| 68 | Map3k1 | 8206 | 0.040 | 0.0266 | No |
| 69 | Ccng2 | 8329 | 0.034 | 0.0212 | No |
| 70 | Ppfia4 | 8353 | 0.033 | 0.0209 | No |
| 71 | B4galnt2 | 8408 | 0.031 | 0.0189 | No |
| 72 | Slc6a6 | 8494 | 0.028 | 0.0153 | No |
| 73 | Pygm | 8532 | 0.026 | 0.0141 | No |
| 74 | Zfp292 | 8724 | 0.019 | 0.0048 | No |
| 75 | Ampd3 | 8833 | 0.014 | -0.0004 | No |
| 76 | Pdk1 | 8869 | 0.012 | -0.0019 | No |
| 77 | F3 | 8925 | 0.011 | -0.0044 | No |
| 78 | Stc2 | 9369 | -0.003 | -0.0269 | No |
| 79 | Tes | 9424 | -0.004 | -0.0296 | No |
| 80 | Aldoa | 9674 | -0.014 | -0.0419 | No |
| 81 | Pfkfb3 | 10129 | -0.032 | -0.0643 | No |
| 82 | Cavin3 | 10205 | -0.036 | -0.0672 | No |
| 83 | Large1 | 10709 | -0.055 | -0.0915 | No |
| 84 | Atp7a | 10815 | -0.060 | -0.0953 | No |
| 85 | Klf7 | 10869 | -0.062 | -0.0965 | No |
| 86 | Ankzf1 | 10886 | -0.063 | -0.0957 | No |
| 87 | Klf6 | 10981 | -0.067 | -0.0988 | No |
| 88 | Scarb1 | 10990 | -0.068 | -0.0975 | No |
| 89 | Ppargc1a | 10996 | -0.068 | -0.0961 | No |
| 90 | Pklr | 11033 | -0.070 | -0.0962 | No |
| 91 | Pam | 11245 | -0.078 | -0.1050 | No |
| 92 | Glrx | 11303 | -0.081 | -0.1059 | No |
| 93 | Nedd4l | 11529 | -0.091 | -0.1151 | No |
| 94 | Fbp1 | 11579 | -0.093 | -0.1153 | No |
| 95 | Pdk3 | 11704 | -0.097 | -0.1191 | No |
| 96 | Dtna | 11795 | -0.101 | -0.1212 | No |
| 97 | Prkca | 11804 | -0.101 | -0.1191 | No |
| 98 | Jun | 12141 | -0.116 | -0.1334 | No |
| 99 | Noct | 12150 | -0.116 | -0.1309 | No |
| 100 | Ldhc | 12248 | -0.120 | -0.1328 | No |
| 101 | Klhl24 | 12260 | -0.120 | -0.1304 | No |
| 102 | Ldha | 12295 | -0.122 | -0.1291 | No |
| 103 | Fam162a | 12677 | -0.135 | -0.1451 | No |
| 104 | Cxcr4 | 12712 | -0.137 | -0.1434 | No |
| 105 | Nagk | 12741 | -0.138 | -0.1414 | No |
| 106 | Il6 | 12773 | -0.139 | -0.1395 | No |
| 107 | Slc37a4 | 12862 | -0.142 | -0.1404 | No |
| 108 | Xpnpep1 | 12986 | -0.147 | -0.1430 | No |
| 109 | Tpst2 | 12999 | -0.148 | -0.1399 | No |
| 110 | Ier3 | 13274 | -0.160 | -0.1499 | No |
| 111 | Gcnt2 | 13547 | -0.173 | -0.1595 | No |
| 112 | Cav1 | 13556 | -0.173 | -0.1555 | No |
| 113 | Gpc4 | 13604 | -0.175 | -0.1536 | No |
| 114 | Rbpj | 13630 | -0.176 | -0.1504 | No |
| 115 | Mif | 13643 | -0.177 | -0.1466 | No |
| 116 | Wsb1 | 13654 | -0.177 | -0.1427 | No |
| 117 | Dcn | 13667 | -0.178 | -0.1389 | No |
| 118 | Tnfaip3 | 13738 | -0.180 | -0.1379 | No |
| 119 | Plac8 | 13765 | -0.181 | -0.1347 | No |
| 120 | Btg1 | 13884 | -0.186 | -0.1361 | No |
| 121 | Nfil3 | 14127 | -0.199 | -0.1435 | No |
| 122 | Plaur | 14469 | -0.214 | -0.1555 | No |
| 123 | Ilvbl | 14496 | -0.216 | -0.1515 | No |
| 124 | Hs3st1 | 14771 | -0.230 | -0.1597 | No |
| 125 | Egfr | 14999 | -0.242 | -0.1652 | No |
| 126 | Irs2 | 15010 | -0.242 | -0.1597 | No |
| 127 | Eno3 | 15093 | -0.246 | -0.1577 | No |
| 128 | Gaa | 15140 | -0.249 | -0.1539 | No |
| 129 | Gpc1 | 15684 | -0.277 | -0.1746 | Yes |
| 130 | Slc2a5 | 15713 | -0.278 | -0.1691 | Yes |
| 131 | Ndrg1 | 15797 | -0.283 | -0.1663 | Yes |
| 132 | Galk1 | 15940 | -0.292 | -0.1662 | Yes |
| 133 | P4ha2 | 16217 | -0.309 | -0.1725 | Yes |
| 134 | Vhl | 16260 | -0.312 | -0.1669 | Yes |
| 135 | Slc2a1 | 16284 | -0.313 | -0.1603 | Yes |
| 136 | Ext1 | 16565 | -0.330 | -0.1663 | Yes |
| 137 | Akap12 | 16664 | -0.337 | -0.1629 | Yes |
| 138 | Selenbp1 | 16846 | -0.347 | -0.1634 | Yes |
| 139 | Slc2a3 | 16934 | -0.354 | -0.1590 | Yes |
| 140 | Slc25a1 | 16981 | -0.357 | -0.1524 | Yes |
| 141 | Ddit3 | 17097 | -0.365 | -0.1492 | Yes |
| 142 | Ppp1r15a | 17115 | -0.366 | -0.1409 | Yes |
| 143 | Fosl2 | 17205 | -0.374 | -0.1361 | Yes |
| 144 | Eno1b | 17326 | -0.384 | -0.1326 | Yes |
| 145 | Csrp2 | 17509 | -0.399 | -0.1319 | Yes |
| 146 | Bcl2 | 17523 | -0.400 | -0.1226 | Yes |
| 147 | Gys1 | 17589 | -0.405 | -0.1158 | Yes |
| 148 | B3galt6 | 17905 | -0.433 | -0.1211 | Yes |
| 149 | Angptl4 | 18062 | -0.449 | -0.1178 | Yes |
| 150 | Aldoc | 18262 | -0.475 | -0.1160 | Yes |
| 151 | Ndst2 | 18375 | -0.491 | -0.1095 | Yes |
| 152 | Gbe1 | 18544 | -0.513 | -0.1052 | Yes |
| 153 | Bgn | 18753 | -0.549 | -0.1021 | Yes |
| 154 | Pdgfb | 18754 | -0.549 | -0.0884 | Yes |
| 155 | Bnip3l | 18792 | -0.557 | -0.0764 | Yes |
| 156 | Sult2b1 | 18843 | -0.566 | -0.0648 | Yes |
| 157 | Prdx5 | 18892 | -0.577 | -0.0528 | Yes |
| 158 | Casp6 | 18939 | -0.585 | -0.0405 | Yes |
| 159 | Eno2 | 19046 | -0.608 | -0.0307 | Yes |
| 160 | Kdelr3 | 19176 | -0.638 | -0.0214 | Yes |
| 161 | Sdc2 | 19260 | -0.663 | -0.0090 | Yes |
| 162 | Cdkn1c | 19327 | -0.687 | 0.0048 | Yes |
| 163 | Cited2 | 19385 | -0.713 | 0.0197 | Yes |

