| Dataset | CMP.CMP_Pheno.cls#Group1_versus_Group4.CMP_Pheno.cls#Group1_versus_Group4_repos |
| Phenotype | CMP_Pheno.cls#Group1_versus_Group4_repos |
| Upregulated in class | 0 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | 0.20998964 |
| Normalized Enrichment Score (NES) | 1.0186002 |
| Nominal p-value | 0.43712574 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.976 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Sqle | 249 | 0.676 | 0.0033 | Yes |
| 2 | Mcm4 | 334 | 0.639 | 0.0141 | Yes |
| 3 | Mcm2 | 655 | 0.545 | 0.0106 | Yes |
| 4 | Gla | 693 | 0.537 | 0.0214 | Yes |
| 5 | Mthfd2l | 729 | 0.530 | 0.0321 | Yes |
| 6 | Ak4 | 796 | 0.516 | 0.0409 | Yes |
| 7 | Insig1 | 906 | 0.499 | 0.0472 | Yes |
| 8 | Stip1 | 990 | 0.490 | 0.0545 | Yes |
| 9 | Serp1 | 1051 | 0.479 | 0.0627 | Yes |
| 10 | Hspa4 | 1216 | 0.455 | 0.0651 | Yes |
| 11 | Me1 | 1231 | 0.453 | 0.0751 | Yes |
| 12 | Fdxr | 1456 | 0.428 | 0.0737 | Yes |
| 13 | Bcat1 | 1575 | 0.414 | 0.0775 | Yes |
| 14 | Canx | 1616 | 0.410 | 0.0851 | Yes |
| 15 | Gtf2h1 | 1624 | 0.409 | 0.0945 | Yes |
| 16 | Map2k3 | 1641 | 0.408 | 0.1033 | Yes |
| 17 | Nufip1 | 1790 | 0.394 | 0.1050 | Yes |
| 18 | Pgm1 | 1835 | 0.388 | 0.1119 | Yes |
| 19 | Ppp1r15a | 1937 | 0.379 | 0.1157 | Yes |
| 20 | Atp2a2 | 1943 | 0.379 | 0.1244 | Yes |
| 21 | Hmgcr | 2018 | 0.373 | 0.1295 | Yes |
| 22 | Fgl2 | 2048 | 0.371 | 0.1367 | Yes |
| 23 | Hspa9 | 2050 | 0.370 | 0.1454 | Yes |
| 24 | Acly | 2233 | 0.357 | 0.1446 | Yes |
| 25 | Cyp51 | 2245 | 0.356 | 0.1524 | Yes |
| 26 | Cct6a | 2276 | 0.353 | 0.1592 | Yes |
| 27 | Ifrd1 | 2352 | 0.347 | 0.1636 | Yes |
| 28 | Hspd1 | 2551 | 0.332 | 0.1613 | Yes |
| 29 | Dhcr24 | 2562 | 0.331 | 0.1686 | Yes |
| 30 | Ldlr | 2685 | 0.322 | 0.1700 | Yes |
| 31 | Psme3 | 2707 | 0.320 | 0.1765 | Yes |
| 32 | Gpi1 | 2821 | 0.314 | 0.1781 | Yes |
| 33 | Rpn1 | 2843 | 0.312 | 0.1844 | Yes |
| 34 | Etf1 | 3180 | 0.290 | 0.1741 | Yes |
| 35 | Stard4 | 3372 | 0.279 | 0.1710 | Yes |
| 36 | Actr2 | 3523 | 0.266 | 0.1696 | Yes |
| 37 | Slc37a4 | 3525 | 0.266 | 0.1758 | Yes |
| 38 | Psat1 | 3603 | 0.262 | 0.1781 | Yes |
| 39 | Tmem97 | 3635 | 0.261 | 0.1827 | Yes |
| 40 | Ykt6 | 3650 | 0.260 | 0.1881 | Yes |
| 41 | Itgb2 | 3712 | 0.256 | 0.1910 | Yes |
| 42 | Ero1a | 3838 | 0.250 | 0.1905 | Yes |
| 43 | Calr | 3915 | 0.244 | 0.1924 | Yes |
| 44 | Ufm1 | 3972 | 0.241 | 0.1953 | Yes |
| 45 | Uso1 | 4024 | 0.239 | 0.1983 | Yes |
| 46 | P4ha1 | 4055 | 0.237 | 0.2024 | Yes |
| 47 | Aldoa | 4452 | 0.217 | 0.1873 | Yes |
| 48 | Pitpnb | 4534 | 0.212 | 0.1881 | Yes |
| 49 | Gga2 | 4735 | 0.201 | 0.1827 | Yes |
| 50 | Elovl5 | 4878 | 0.193 | 0.1800 | Yes |
| 51 | Gsk3b | 4896 | 0.192 | 0.1837 | Yes |
| 52 | Nup205 | 4959 | 0.189 | 0.1850 | Yes |
| 53 | Psmc6 | 5039 | 0.184 | 0.1853 | Yes |
| 54 | Cdkn1a | 5106 | 0.180 | 0.1862 | Yes |
| 55 | Immt | 5297 | 0.173 | 0.1805 | Yes |
| 56 | Psmg1 | 5346 | 0.171 | 0.1821 | Yes |
| 57 | Aurka | 5384 | 0.170 | 0.1843 | Yes |
| 58 | Wars1 | 5446 | 0.167 | 0.1851 | Yes |
| 59 | Rrm2 | 5489 | 0.166 | 0.1869 | Yes |
| 60 | Pno1 | 5492 | 0.165 | 0.1907 | Yes |
| 61 | Slc2a3 | 5493 | 0.165 | 0.1946 | Yes |
| 62 | Qdpr | 5511 | 0.165 | 0.1976 | Yes |
| 63 | Hspa5 | 5552 | 0.163 | 0.1994 | Yes |
| 64 | Pdk1 | 5565 | 0.162 | 0.2026 | Yes |
| 65 | G6pdx | 5673 | 0.157 | 0.2009 | Yes |
| 66 | Hmgcs1 | 5680 | 0.157 | 0.2043 | Yes |
| 67 | Cdc25a | 5727 | 0.154 | 0.2056 | Yes |
| 68 | Bub1 | 5798 | 0.151 | 0.2055 | Yes |
| 69 | Sc5d | 5839 | 0.148 | 0.2070 | Yes |
| 70 | Hsp90b1 | 5850 | 0.148 | 0.2100 | Yes |
| 71 | Plk1 | 6051 | 0.139 | 0.2031 | No |
| 72 | Pgk1 | 6075 | 0.138 | 0.2052 | No |
| 73 | Idh1 | 6098 | 0.137 | 0.2073 | No |
| 74 | Slc7a5 | 6239 | 0.132 | 0.2032 | No |
| 75 | Gmps | 6353 | 0.126 | 0.2004 | No |
| 76 | Ssr1 | 6452 | 0.121 | 0.1983 | No |
| 77 | Ube2d3 | 6565 | 0.116 | 0.1953 | No |
| 78 | Abcf2 | 6582 | 0.115 | 0.1972 | No |
| 79 | Psmd14 | 7001 | 0.102 | 0.1783 | No |
| 80 | Slc7a11 | 7005 | 0.102 | 0.1805 | No |
| 81 | Tubg1 | 7275 | 0.090 | 0.1689 | No |
| 82 | Ccng1 | 7278 | 0.090 | 0.1710 | No |
| 83 | Nampt | 7322 | 0.089 | 0.1709 | No |
| 84 | Idi1 | 7423 | 0.084 | 0.1677 | No |
| 85 | Rrp9 | 7451 | 0.083 | 0.1683 | No |
| 86 | Niban1 | 7504 | 0.081 | 0.1676 | No |
| 87 | Tm7sf2 | 7613 | 0.077 | 0.1639 | No |
| 88 | Slc1a5 | 7635 | 0.076 | 0.1646 | No |
| 89 | Add3 | 7703 | 0.073 | 0.1629 | No |
| 90 | Nfyc | 7768 | 0.069 | 0.1613 | No |
| 91 | Plod2 | 7893 | 0.064 | 0.1564 | No |
| 92 | Hk2 | 7929 | 0.062 | 0.1561 | No |
| 93 | Rab1a | 7972 | 0.061 | 0.1554 | No |
| 94 | Tpi1 | 8048 | 0.058 | 0.1529 | No |
| 95 | Asns | 8088 | 0.056 | 0.1523 | No |
| 96 | Fads1 | 8090 | 0.056 | 0.1536 | No |
| 97 | Rpa1 | 8179 | 0.052 | 0.1503 | No |
| 98 | Ddx39a | 8212 | 0.051 | 0.1499 | No |
| 99 | Hmbs | 8236 | 0.050 | 0.1499 | No |
| 100 | Got1 | 8290 | 0.048 | 0.1483 | No |
| 101 | Lgmn | 8514 | 0.040 | 0.1378 | No |
| 102 | Hspe1 | 8693 | 0.032 | 0.1295 | No |
| 103 | M6pr | 8759 | 0.029 | 0.1269 | No |
| 104 | Rit1 | 8813 | 0.027 | 0.1248 | No |
| 105 | Actr3 | 8899 | 0.024 | 0.1211 | No |
| 106 | Cops5 | 8971 | 0.022 | 0.1180 | No |
| 107 | Dhcr7 | 9009 | 0.021 | 0.1166 | No |
| 108 | Ccnf | 9275 | 0.009 | 0.1032 | No |
| 109 | Srd5a1 | 9294 | 0.009 | 0.1025 | No |
| 110 | Adipor2 | 9364 | 0.006 | 0.0991 | No |
| 111 | Edem1 | 9408 | 0.004 | 0.0970 | No |
| 112 | Cyb5b | 9419 | 0.004 | 0.0966 | No |
| 113 | Txnrd1 | 9430 | 0.003 | 0.0962 | No |
| 114 | Xbp1 | 9474 | 0.002 | 0.0940 | No |
| 115 | Vldlr | 9934 | -0.012 | 0.0709 | No |
| 116 | Tbk1 | 10024 | -0.015 | 0.0667 | No |
| 117 | Rdh11 | 10394 | -0.029 | 0.0485 | No |
| 118 | Gbe1 | 10547 | -0.036 | 0.0416 | No |
| 119 | Lta4h | 10674 | -0.041 | 0.0361 | No |
| 120 | Atp6v1d | 10694 | -0.041 | 0.0362 | No |
| 121 | Skap2 | 10768 | -0.045 | 0.0335 | No |
| 122 | Ppa1 | 10833 | -0.047 | 0.0313 | No |
| 123 | Tcea1 | 10979 | -0.053 | 0.0252 | No |
| 124 | Ppia | 11043 | -0.056 | 0.0233 | No |
| 125 | Psmc4 | 11072 | -0.057 | 0.0232 | No |
| 126 | Elovl6 | 11174 | -0.061 | 0.0195 | No |
| 127 | Uchl5 | 11237 | -0.064 | 0.0178 | No |
| 128 | Gclc | 11244 | -0.064 | 0.0190 | No |
| 129 | Pik3r3 | 11346 | -0.068 | 0.0155 | No |
| 130 | Ifi30 | 11447 | -0.073 | 0.0121 | No |
| 131 | Nfil3 | 11681 | -0.083 | 0.0022 | No |
| 132 | Sqstm1 | 11773 | -0.086 | -0.0004 | No |
| 133 | Psma3 | 12055 | -0.098 | -0.0125 | No |
| 134 | Slc1a4 | 12273 | -0.108 | -0.0210 | No |
| 135 | Pfkl | 12365 | -0.113 | -0.0230 | No |
| 136 | Ctsc | 12602 | -0.123 | -0.0321 | No |
| 137 | Eno1b | 12868 | -0.131 | -0.0426 | No |
| 138 | Psmd12 | 13335 | -0.152 | -0.0628 | No |
| 139 | Sec11a | 13430 | -0.156 | -0.0639 | No |
| 140 | Psph | 13434 | -0.156 | -0.0604 | No |
| 141 | Eif2s2 | 13503 | -0.160 | -0.0601 | No |
| 142 | Sord | 13574 | -0.162 | -0.0598 | No |
| 143 | Ung | 13803 | -0.172 | -0.0674 | No |
| 144 | Nupr1 | 14017 | -0.178 | -0.0741 | No |
| 145 | Slc2a1 | 14034 | -0.179 | -0.0707 | No |
| 146 | Dapp1 | 14073 | -0.181 | -0.0683 | No |
| 147 | Psmb5 | 14141 | -0.184 | -0.0674 | No |
| 148 | Btg2 | 14157 | -0.186 | -0.0638 | No |
| 149 | Psmc2 | 14175 | -0.187 | -0.0602 | No |
| 150 | Polr3g | 14333 | -0.195 | -0.0637 | No |
| 151 | Phgdh | 14439 | -0.201 | -0.0643 | No |
| 152 | Tuba4a | 14613 | -0.210 | -0.0682 | No |
| 153 | Fkbp2 | 14749 | -0.217 | -0.0699 | No |
| 154 | Slc6a6 | 14757 | -0.218 | -0.0651 | No |
| 155 | Pdap1 | 14875 | -0.224 | -0.0658 | No |
| 156 | Glrx | 15078 | -0.235 | -0.0706 | No |
| 157 | Prdx1 | 15148 | -0.238 | -0.0685 | No |
| 158 | Acsl3 | 15170 | -0.239 | -0.0639 | No |
| 159 | Mllt11 | 15515 | -0.258 | -0.0754 | No |
| 160 | Psma4 | 15547 | -0.260 | -0.0708 | No |
| 161 | Gsr | 15555 | -0.261 | -0.0650 | No |
| 162 | Acaca | 15571 | -0.261 | -0.0596 | No |
| 163 | Arpc5l | 15589 | -0.262 | -0.0542 | No |
| 164 | Trib3 | 15622 | -0.265 | -0.0496 | No |
| 165 | Ldha | 15825 | -0.273 | -0.0535 | No |
| 166 | Nmt1 | 15836 | -0.274 | -0.0475 | No |
| 167 | Dhfr | 15853 | -0.275 | -0.0419 | No |
| 168 | Cxcr4 | 15890 | -0.277 | -0.0372 | No |
| 169 | Tes | 15918 | -0.279 | -0.0320 | No |
| 170 | Shmt2 | 15951 | -0.281 | -0.0270 | No |
| 171 | Tomm40 | 16061 | -0.287 | -0.0258 | No |
| 172 | Bhlhe40 | 16086 | -0.288 | -0.0202 | No |
| 173 | Sla | 16189 | -0.295 | -0.0184 | No |
| 174 | Coro1a | 16673 | -0.326 | -0.0354 | No |
| 175 | Serpinh1 | 16789 | -0.333 | -0.0334 | No |
| 176 | Tfrc | 16878 | -0.337 | -0.0299 | No |
| 177 | Cth | 16984 | -0.343 | -0.0272 | No |
| 178 | Egln3 | 17096 | -0.353 | -0.0245 | No |
| 179 | Fads2 | 17148 | -0.357 | -0.0187 | No |
| 180 | Ddit4 | 17175 | -0.360 | -0.0115 | No |
| 181 | Sdf2l1 | 17317 | -0.371 | -0.0099 | No |
| 182 | Mthfd2 | 17523 | -0.389 | -0.0112 | No |
| 183 | Cfp | 17750 | -0.406 | -0.0131 | No |
| 184 | Nfkbib | 17779 | -0.409 | -0.0049 | No |
| 185 | Psmd13 | 17796 | -0.411 | 0.0040 | No |
| 186 | Cd9 | 18179 | -0.448 | -0.0049 | No |
| 187 | Eef1e1 | 18311 | -0.464 | -0.0007 | No |
| 188 | Ddit3 | 18645 | -0.507 | -0.0057 | No |
| 189 | Sytl2 | 18746 | -0.524 | 0.0016 | No |
| 190 | Pnp | 19319 | -0.657 | -0.0121 | No |
| 191 | Cacybp | 19480 | -0.715 | -0.0034 | No |
| 192 | Ebp | 19574 | -0.771 | 0.0101 | No |

