| Dataset | CMP.CMP_Pheno.cls#Group1_versus_Group3.CMP_Pheno.cls#Group1_versus_Group3_repos |
| Phenotype | CMP_Pheno.cls#Group1_versus_Group3_repos |
| Upregulated in class | 0 |
| GeneSet | HALLMARK_P53_PATHWAY |
| Enrichment Score (ES) | 0.15906218 |
| Normalized Enrichment Score (NES) | 0.70696884 |
| Nominal p-value | 0.9489796 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | H2ac25 | 1 | 1.569 | 0.0378 | Yes |
| 2 | Slc7a11 | 128 | 0.713 | 0.0485 | Yes |
| 3 | St14 | 391 | 0.560 | 0.0486 | Yes |
| 4 | Rxra | 473 | 0.535 | 0.0574 | Yes |
| 5 | Btg1 | 509 | 0.525 | 0.0683 | Yes |
| 6 | Rhbdf2 | 866 | 0.459 | 0.0612 | Yes |
| 7 | Ppp1r15a | 877 | 0.457 | 0.0717 | Yes |
| 8 | Zfp365 | 992 | 0.437 | 0.0764 | Yes |
| 9 | Hexim1 | 996 | 0.437 | 0.0868 | Yes |
| 10 | Polh | 1374 | 0.387 | 0.0769 | Yes |
| 11 | Fos | 1492 | 0.373 | 0.0799 | Yes |
| 12 | Foxo3 | 1681 | 0.357 | 0.0789 | Yes |
| 13 | Tgfa | 1716 | 0.354 | 0.0857 | Yes |
| 14 | Socs1 | 1749 | 0.350 | 0.0925 | Yes |
| 15 | Trafd1 | 1813 | 0.345 | 0.0976 | Yes |
| 16 | Cgrrf1 | 1924 | 0.336 | 0.1001 | Yes |
| 17 | Abcc5 | 1993 | 0.330 | 0.1046 | Yes |
| 18 | Aen | 2028 | 0.328 | 0.1108 | Yes |
| 19 | Cdkn2aip | 2094 | 0.323 | 0.1152 | Yes |
| 20 | Tap1 | 2130 | 0.321 | 0.1212 | Yes |
| 21 | Txnip | 2260 | 0.312 | 0.1221 | Yes |
| 22 | Sdc1 | 2294 | 0.309 | 0.1279 | Yes |
| 23 | Nudt15 | 2445 | 0.299 | 0.1274 | Yes |
| 24 | Fas | 2636 | 0.288 | 0.1247 | Yes |
| 25 | Jun | 2674 | 0.284 | 0.1296 | Yes |
| 26 | Hmox1 | 2676 | 0.284 | 0.1364 | Yes |
| 27 | Stom | 2760 | 0.278 | 0.1389 | Yes |
| 28 | Sp1 | 2940 | 0.267 | 0.1362 | Yes |
| 29 | Ccng1 | 2979 | 0.264 | 0.1406 | Yes |
| 30 | Rab40c | 3108 | 0.256 | 0.1402 | Yes |
| 31 | Baiap2 | 3175 | 0.253 | 0.1429 | Yes |
| 32 | Slc3a2 | 3235 | 0.248 | 0.1459 | Yes |
| 33 | Ip6k2 | 3330 | 0.242 | 0.1469 | Yes |
| 34 | Mdm2 | 3352 | 0.240 | 0.1517 | Yes |
| 35 | Hbegf | 3417 | 0.238 | 0.1541 | Yes |
| 36 | Slc19a2 | 3433 | 0.237 | 0.1591 | Yes |
| 37 | Epha2 | 3545 | 0.231 | 0.1590 | No |
| 38 | Ctsf | 3705 | 0.222 | 0.1562 | No |
| 39 | Rad51c | 3874 | 0.213 | 0.1528 | No |
| 40 | Elp1 | 4231 | 0.196 | 0.1393 | No |
| 41 | Ccnk | 4253 | 0.196 | 0.1430 | No |
| 42 | Ptpn14 | 4255 | 0.196 | 0.1476 | No |
| 43 | F2r | 4486 | 0.183 | 0.1403 | No |
| 44 | Pom121 | 4783 | 0.171 | 0.1293 | No |
| 45 | Abat | 4979 | 0.161 | 0.1233 | No |
| 46 | Cdkn2a | 5106 | 0.156 | 0.1206 | No |
| 47 | H2aj | 5241 | 0.149 | 0.1173 | No |
| 48 | Wrap73 | 5401 | 0.141 | 0.1126 | No |
| 49 | Tax1bp3 | 5406 | 0.141 | 0.1158 | No |
| 50 | Cyfip2 | 5521 | 0.136 | 0.1133 | No |
| 51 | Fdxr | 5540 | 0.136 | 0.1156 | No |
| 52 | Kif13b | 5591 | 0.134 | 0.1163 | No |
| 53 | Traf4 | 5999 | 0.119 | 0.0984 | No |
| 54 | Ada | 6210 | 0.113 | 0.0904 | No |
| 55 | Ankra2 | 6235 | 0.112 | 0.0919 | No |
| 56 | Tob1 | 6305 | 0.110 | 0.0910 | No |
| 57 | Ier5 | 6466 | 0.102 | 0.0853 | No |
| 58 | Rnf19b | 6468 | 0.102 | 0.0877 | No |
| 59 | Fgf13 | 6736 | 0.092 | 0.0763 | No |
| 60 | Pvt1 | 6789 | 0.090 | 0.0758 | No |
| 61 | Klk8 | 6805 | 0.090 | 0.0772 | No |
| 62 | Hspa4l | 6851 | 0.088 | 0.0771 | No |
| 63 | Klf4 | 6955 | 0.085 | 0.0738 | No |
| 64 | Vwa5a | 7066 | 0.080 | 0.0702 | No |
| 65 | Pcna | 7218 | 0.075 | 0.0643 | No |
| 66 | Ccp110 | 7291 | 0.072 | 0.0623 | No |
| 67 | Rap2b | 7299 | 0.072 | 0.0637 | No |
| 68 | Ninj1 | 7538 | 0.062 | 0.0530 | No |
| 69 | Plk2 | 7539 | 0.062 | 0.0545 | No |
| 70 | Sphk1 | 7578 | 0.061 | 0.0540 | No |
| 71 | Pdgfa | 7832 | 0.052 | 0.0424 | No |
| 72 | Steap3 | 7887 | 0.051 | 0.0409 | No |
| 73 | Alox8 | 8039 | 0.045 | 0.0342 | No |
| 74 | Slc35d1 | 8101 | 0.043 | 0.0322 | No |
| 75 | Vdr | 8114 | 0.043 | 0.0326 | No |
| 76 | Casp1 | 8209 | 0.039 | 0.0287 | No |
| 77 | Def6 | 8210 | 0.039 | 0.0297 | No |
| 78 | Ercc5 | 8226 | 0.039 | 0.0298 | No |
| 79 | Rrp8 | 8308 | 0.036 | 0.0266 | No |
| 80 | Acvr1b | 8501 | 0.029 | 0.0175 | No |
| 81 | Zmat3 | 8514 | 0.029 | 0.0175 | No |
| 82 | Wwp1 | 8732 | 0.020 | 0.0070 | No |
| 83 | Fbxw7 | 8752 | 0.020 | 0.0065 | No |
| 84 | Pmm1 | 8774 | 0.019 | 0.0059 | No |
| 85 | Irag2 | 8777 | 0.019 | 0.0062 | No |
| 86 | Mapkapk3 | 8875 | 0.015 | 0.0016 | No |
| 87 | Hdac3 | 8899 | 0.014 | 0.0008 | No |
| 88 | Tnfsf9 | 9078 | 0.008 | -0.0081 | No |
| 89 | Lif | 9292 | 0.000 | -0.0190 | No |
| 90 | Apaf1 | 9629 | -0.010 | -0.0359 | No |
| 91 | Sertad3 | 9787 | -0.017 | -0.0435 | No |
| 92 | Sat1 | 9948 | -0.022 | -0.0512 | No |
| 93 | Hint1 | 10116 | -0.028 | -0.0590 | No |
| 94 | Abhd4 | 10223 | -0.032 | -0.0637 | No |
| 95 | Dgka | 10263 | -0.034 | -0.0648 | No |
| 96 | Jag2 | 10354 | -0.037 | -0.0685 | No |
| 97 | Trib3 | 10358 | -0.038 | -0.0678 | No |
| 98 | Triap1 | 10437 | -0.040 | -0.0708 | No |
| 99 | Eps8l2 | 10576 | -0.045 | -0.0767 | No |
| 100 | Coq8a | 10597 | -0.046 | -0.0766 | No |
| 101 | Fam162a | 10748 | -0.051 | -0.0831 | No |
| 102 | Notch1 | 10798 | -0.053 | -0.0843 | No |
| 103 | Mknk2 | 10807 | -0.053 | -0.0834 | No |
| 104 | Cdk5r1 | 10868 | -0.055 | -0.0852 | No |
| 105 | Perp | 11000 | -0.059 | -0.0904 | No |
| 106 | Atf3 | 11014 | -0.060 | -0.0896 | No |
| 107 | Rb1 | 11131 | -0.062 | -0.0941 | No |
| 108 | Rad9a | 11132 | -0.062 | -0.0926 | No |
| 109 | S100a4 | 11173 | -0.064 | -0.0931 | No |
| 110 | Zbtb16 | 11209 | -0.065 | -0.0933 | No |
| 111 | H1f2 | 11350 | -0.071 | -0.0987 | No |
| 112 | Trp53 | 11445 | -0.075 | -0.1017 | No |
| 113 | Zfp36l1 | 11784 | -0.088 | -0.1169 | No |
| 114 | Nupr1 | 11813 | -0.089 | -0.1162 | No |
| 115 | Upp1 | 11909 | -0.094 | -0.1188 | No |
| 116 | Csrnp2 | 12013 | -0.099 | -0.1216 | No |
| 117 | Btg2 | 12017 | -0.099 | -0.1194 | No |
| 118 | Sesn1 | 12074 | -0.101 | -0.1198 | No |
| 119 | Cdkn1a | 12166 | -0.105 | -0.1220 | No |
| 120 | Tchh | 12461 | -0.117 | -0.1341 | No |
| 121 | Ppm1d | 12549 | -0.120 | -0.1357 | No |
| 122 | Dcxr | 12628 | -0.123 | -0.1367 | No |
| 123 | Sec61a1 | 12759 | -0.128 | -0.1403 | No |
| 124 | Nol8 | 12822 | -0.131 | -0.1403 | No |
| 125 | Ccnd2 | 12905 | -0.134 | -0.1412 | No |
| 126 | Blcap | 12964 | -0.137 | -0.1409 | No |
| 127 | App | 12973 | -0.137 | -0.1380 | No |
| 128 | Mxd4 | 13194 | -0.145 | -0.1457 | No |
| 129 | Cd82 | 13417 | -0.154 | -0.1534 | No |
| 130 | Bax | 13473 | -0.157 | -0.1524 | No |
| 131 | Pidd1 | 13475 | -0.157 | -0.1487 | No |
| 132 | Plxnb2 | 13542 | -0.159 | -0.1482 | No |
| 133 | Rrad | 13625 | -0.163 | -0.1484 | No |
| 134 | Tsc22d1 | 13720 | -0.167 | -0.1492 | No |
| 135 | Ptpre | 13726 | -0.168 | -0.1454 | No |
| 136 | Ddit4 | 13776 | -0.170 | -0.1438 | No |
| 137 | Dnttip2 | 13822 | -0.172 | -0.1420 | No |
| 138 | Tm7sf3 | 13845 | -0.173 | -0.1389 | No |
| 139 | Bak1 | 13983 | -0.180 | -0.1416 | No |
| 140 | Prmt2 | 13999 | -0.181 | -0.1380 | No |
| 141 | Xpc | 14016 | -0.182 | -0.1344 | No |
| 142 | Cebpa | 14073 | -0.184 | -0.1328 | No |
| 143 | Ndrg1 | 14167 | -0.188 | -0.1330 | No |
| 144 | Plk3 | 14192 | -0.190 | -0.1297 | No |
| 145 | Mxd1 | 14266 | -0.194 | -0.1287 | No |
| 146 | Tpd52l1 | 14342 | -0.198 | -0.1278 | No |
| 147 | Iscu | 14475 | -0.206 | -0.1296 | No |
| 148 | Ephx1 | 14582 | -0.210 | -0.1299 | No |
| 149 | Ctsd | 14754 | -0.219 | -0.1334 | No |
| 150 | Osgin1 | 14771 | -0.219 | -0.1289 | No |
| 151 | Ifi30 | 15087 | -0.235 | -0.1393 | No |
| 152 | Pitpnc1 | 15372 | -0.247 | -0.1479 | No |
| 153 | Ddb2 | 15393 | -0.248 | -0.1429 | No |
| 154 | Hras | 15564 | -0.258 | -0.1453 | No |
| 155 | Ak1 | 15822 | -0.273 | -0.1519 | No |
| 156 | Rps12 | 15941 | -0.281 | -0.1511 | No |
| 157 | Cd81 | 15974 | -0.284 | -0.1459 | No |
| 158 | Rpl18 | 16057 | -0.289 | -0.1431 | No |
| 159 | Ei24 | 16170 | -0.296 | -0.1417 | No |
| 160 | Gls2 | 16181 | -0.296 | -0.1351 | No |
| 161 | Tcn2 | 16364 | -0.307 | -0.1370 | No |
| 162 | Sfn | 16622 | -0.325 | -0.1423 | No |
| 163 | Itgb4 | 16679 | -0.329 | -0.1372 | No |
| 164 | Tgfb1 | 16909 | -0.345 | -0.1406 | No |
| 165 | Trp63 | 17211 | -0.366 | -0.1471 | No |
| 166 | Tspyl2 | 17215 | -0.366 | -0.1384 | No |
| 167 | Prkab1 | 17311 | -0.375 | -0.1342 | No |
| 168 | Fuca1 | 17404 | -0.383 | -0.1297 | No |
| 169 | Procr | 17621 | -0.401 | -0.1311 | No |
| 170 | Dram1 | 17796 | -0.417 | -0.1299 | No |
| 171 | Ralgds | 17875 | -0.425 | -0.1236 | No |
| 172 | Ier3 | 17884 | -0.426 | -0.1138 | No |
| 173 | Ccnd3 | 17954 | -0.431 | -0.1069 | No |
| 174 | Irak1 | 18042 | -0.441 | -0.1007 | No |
| 175 | Tprkb | 18131 | -0.447 | -0.0944 | No |
| 176 | Rps27l | 18161 | -0.451 | -0.0850 | No |
| 177 | Retsat | 18410 | -0.477 | -0.0862 | No |
| 178 | Ldhb | 18489 | -0.488 | -0.0784 | No |
| 179 | Rpl36 | 18526 | -0.495 | -0.0683 | No |
| 180 | Vamp8 | 18533 | -0.497 | -0.0566 | No |
| 181 | Cdh13 | 18653 | -0.514 | -0.0503 | No |
| 182 | Rchy1 | 18811 | -0.540 | -0.0453 | No |
| 183 | Phlda3 | 18928 | -0.559 | -0.0378 | No |
| 184 | Rack1 | 19062 | -0.587 | -0.0304 | No |
| 185 | S100a10 | 19089 | -0.593 | -0.0175 | No |
| 186 | Ddit3 | 19255 | -0.636 | -0.0105 | No |
| 187 | Gadd45a | 19302 | -0.655 | 0.0029 | No |
| 188 | Gm2a | 19656 | -0.871 | 0.0059 | No |

