Rink Neiro NewGuoGenome Symbol Old symbol Description TF group TF class Identification RNAi In situ Reference X1 X2 Xins X1 percent X2 percent Xins percent Jaspar MatrixID Jaspar Evalue SMESG000003328.1 MSTRG.707 SmMSTRG.707 fos-1 Fos proto-oncogene FOS Basic domain 1 Cyclopic blastemas and asymmetric tails Ubiquitous (Wenemoser et al., 2012; Zhu et al., 2015) 73.5310499673311 56.195082470989 82.5715237972318 0.346358274844757 0.264699495356833 0.38894222979841 0 0 SMESG000062649.1 MSTRG.18685 SmMSTRG.18685 batf-3 Basic leucine zipper transcription factor ATF-like 3 BATF Basic domain 0 0 0 67.4493763848101 56.3388308177304 120.66160137338 0.27592321212173 0.230471977646212 0.493604810232057 0 0 - MSTRG.20486 SmMSTRG.20486 maf Maf domain containing protein MAF Basic domain 0 0 0 18.1352840359893 30.1360513716493 20.5504735800492 0.263510714157974 0.43788519678465 0.298604089057376 0 0 SMESG000044121.1 MSTRG.13956 SMEST044121001 atf1 ATFl1 Cyclic AMP-dependent transcription factor ATF-1 ATF Basic domain 1 0 0 (Wenemoser et al., 2012) 19.9753857153183 73.7543513671358 29.4751041290362 0.162131500019785 0.598631925839107 0.239236574141108 0 0 SMESG000012495.1 MSTRG.4585 SmMSTRG.4585 atf2-1 Cyclic AMP-dependent transcription factor ATF-2-1 ATF Basic domain 0 0 0 39.0165129089086 11.2121043335458 10.6166444241653 0.641241599431126 0.184272431844875 0.174485968723998 0 0 SMESG000069925.1 MSTRG.19298 SMEST069925001 atf2-2 Cyclic AMP-dependent transcription factor ATF-2-1 ATF Basic domain 0 0 0 36.8220814281468 2.89636029474332 2.48688988704227 0.872450944550363 0.0686254599658615 0.0589235954837758 0 0 SMESG000062724.1 MSTRG.18724 SmMSTRG.18724 creb3l-4 Cyclic AMP-responsive element-binding protein 3-like protein 4 CREB Basic domain 0 0 0 18.0859059513831 19.3750816855328 21.889817655887 0.304728905735273 0.326450190354574 0.368820903910152 0 0 SMESG000065680.1 MSTRG.19544 SmMSTRG.19544 creb3l-1 Cyclic AMP-responsive element-binding protein 3-like 1 CREB Basic domain 0 0 0 4.97840186993715 59.7558735916747 50.2522747882207 0.0432955146416734 0.519677070595147 0.437027414763179 MA0839.1 9.2766E-36 SMESG000052278.1 MSTRG.16107 SMEST052278001 creb Cyclic AMP-responsive element-binding protein CREB Basic domain 0 0 0 16.8902970565803 75.2762493361466 47.4171965580379 0.121004758143919 0.539290949969 0.339704291887081 0 0 SMESG000010254.1 MSTRG.3920 SmMSTRG.3920 hlf Hepatic leukemia factor  HLF Basic domain 0 0 0 3.5961514521993 2.39263683002984 6.31536154862042 0.292271428878642 0.19445771247282 0.513270858648538 0 0 SMESG000026144.1 MSTRG.586 SmMSTRG.586 pdp1 PAR domain protein 1 Pdp Basic domain 0 0 0 2.35967776436847 13.4635316811535 4.6472080868137 0.115272576176868 0.657706744861756 0.227020678961376 MA0025.1 4.38979E-10 SMESG000032044.1 MSTRG.10086 SmMSTRG.10086 da Daughterless E2A Basic domain 1 Eye defects Ubiquitous (Cowles et al., 2013; Scimone et al., 2018) 27.3450858733902 28.8017690029462 6.73921162076361 0.434835368096225 0.457999213613948 0.107165418289827 MA0830.1 1.07415E-40 SMESG000034317.1 MSTRG.11214 SMEST034317001 myoD Myogenic differentiation 1 MYOD Basic domain 1 CNS and blastema defect Mesenchyme (Cowles et al., 2013; Scimone et al., 2018; Raz et al., 2021) 6.05759158418401 4.91921976604494 6.69660079264025 0.342751673260113 0.278340126189482 0.378908200550405 MA0499.1 2.13413E-21 SMESG000032619.1 MSTRG.10663 SMEST032619001 ascl-2 Achaete scute like-2 MYOD Basic domain 1 No defect Mesenchyme (Cowles et al., 2013; Fincher et al., 2018) 6.3505724570755 9.94751513158667 12.0705746951516 0.223858721061335 0.35065154049447 0.425489738444195 0 0 SMESG000026861.1 MSTRG.27 SMEST026861001 ascl-4 ASCL4 Achaete scute like-4 MYOD Basic domain 1 0 0 (Fincher et al., 2018) 8.37552290380287 18.3305982871276 43.9347189137205 0.118564882458857 0.259490094681373 0.62194502285977 0 0 SMESG000067729.1 MSTRG.20131 SMEST067729002 tal T-cell acute lymphocytic leukemia TAL Basic domain 1 0 Mesenchyme (Cowles et al., 2013) 0.02002072486051 0.58250391690683 0.58737639341317 0.0168255378124558 0.48953980178567 0.493634660401874 MA0091.1 2.67364E-16 SMESG000026385.1 MSTRG.657 SMEST026385001 twist Twist Family BHLH Transcription Factor TWIST Basic domain 1 0 Pharynx, Mesenchyme (Cowles et al., 2013; Scimone et al., 2018) 0.934814640421463 0.31775253048761 0.153296319957818 0.664939836971677 0.226019476678831 0.109040686349492 MA0249.1 4.75747E-23 SMESG000044395.1 MSTRG.13829 SmMSTRG.13829 tcf15 Transcription factor 15 TCF15 Basic domain 1 0 Neoblasts, Epidermis (Wagner et al., 2012; van Wolfswinkel et al., 2014; Cheng et al., 2018) 176.397335535441 75.9342431789147 91.4839118019447 0.513058138452543 0.220857539213506 0.266084322333951 0 0 - MSTRG.5969 SmMSTRG.5969 ptf-1 Pancreas specific transcription factor-1 PTF Basic domain 1 0 Mesenchyme (Cowles et al., 2013) 1.05985747400846 0.046491818371209 1.20101614370843 0.459336634514792 0.0201493086634906 0.520514056821717 0 0 SMESG000000956.1 MSTRG.1216 SmMSTRG.1216 ptf-2 Pancreas specific transcription factor-2 PTF Basic domain 1 0 Mesenchyme (Cowles et al., 2013) 0.133881470599878 0.929154367593247 2.84733699830881 0.0342375206144391 0.237612730663409 0.728149748722152 0 0 SMESG000045286.1 MSTRG.13983 SmMSTRG.13983 ptf-3 Pancreas specific transcription factor-3 PTF Basic domain 1 0 Mesenchyme (Cowles et al., 2013) 0.341352060915572 0.522283495670548 3.43593732456094 0.0793920862261334 0.121473344006024 0.799134569767843 0 0 SMESG000079648.1 MSTRG.23258 SmMSTRG.23258 ptf-4 Pancreas specific transcription factor-4 PTF Basic domain 1 0 Mesenchyme (Cowles et al., 2013) 0.852011135249907 5.77578589013169 7.06593918108886 0.0622190410566928 0.421783054897944 0.515997904045363 MA0091.1 1.0417E-10 SMESG000040081.1 MSTRG.12572 SMEST040081001 ptf-5 PTF1A Pancreas specific transcription factor-5 PTF Basic domain 1 Goblet cell defects Pharynx, Intestine, Mesenchyme (Cowles et al., 2013; Fincher et al., 2018; Forsthoefel et al., 2020) 0.189229061237116 11.3252345118817 3.51185658272978 0.0125931737960117 0.753693146054369 0.23371368014962 MA0832.1 1.14419E-07 SMESG000018258.1 MSTRG.6445 SmMSTRG.6445 musculin MSC Musculin MSC Basic domain 1 0 CNS, Mesenchyme (Cowles et al., 2013) 9.01902332764396 1.65825414102118 1.0010283047849 0.772288678050218 0.141994410250083 0.0857169116996987 MA0665.1 9.57759E-14 SMESG000066244.1 MSTRG.19581 SmMSTRG.19581 neuroD-1 Neurogenic differentiation 1 NEUROD Basic domain 1 No defect CNS, Mesenchyme (Cowles et al., 2013) 9.55752800665616 1.2797691117191 1.17987242738661 0.795322723063921 0.10649505333562 0.0981822236004586 MA0668.1 2.2419E-26 SMESG000081091.1 MSTRG.22726 SMEST081091001 neuroD-2 Neurogenic differentiation 2 NEUROD Basic domain 1 No defect 0 (Cowles et al., 2013) 3.4507983181266 6.22488319520114 8.4893323581011 0.189969484336825 0.342685298192481 0.467345217470695 MA0827.1 1.31891E-06 SMESG000031948.1 MSTRG.10058 SMEST031948001 neuroD-3 neurod Neurogenic differentiation 3 NEUROD Basic domain 1 0 CNS (van Wolfswinkel et al., 2014) 24.5896397183217 33.9753907971624 12.2050754173214 0.347458003548404 0.48008110697787 0.172460889473726 0 0 SMESG000018830.1 MSTRG.6032 SMEST018830001 atoh8-1 Atonal homolog 8-1 NEUROD Basic domain 1 CNS defect Pharynx, Mesenchyme (Cowles et al., 2013) 6.97366544212863 5.23373075730677 7.18202721486175 0.359663373846716 0.26992709610166 0.370409530051623 0 0 SMESG000056587.1 MSTRG.17089 SMEST056587001 atoh8-2 atonal Atonal homolog 8-2 NEUROD Basic domain 1 0 Pharynx, Intestine, Mesenchyme (Cowles et al., 2013; van Wolfswinkel et al., 2014) 18.7680649318648 14.3025225210005 18.4165994318954 0.364519137040284 0.277787997099406 0.357692865860309 0 0 SMESG000060238.1 MSTRG.17998 SMEST060238001 olig Oligodendrocyte transcription factor NEUROD Basic domain 1 0 Mesenchyme (Cowles et al., 2013) 124.105654984151 8.96203120685243 2.36047287389099 0.916394757494135 0.0661755374121123 0.017429705093753 MA0827.1 6.75705E-33 SMESG000029000.1 MSTRG.9259 SMEST029000002 fer3l-1 Fer3-like protein 1 FER3 Basic domain 1 0 CNS (Cowles et al., 2013) 45.0102396476274 17.3087618512866 8.15243530914622 0.638701886698007 0.245613863364666 0.115684249937327 0 0 SMESG000019274.1 MSTRG.6136 SmMSTRG.6136 fer3l-2 Fer3-like protein 2 FER3 Basic domain 1 0 Mesenchyme (Cowles et al., 2013; Scimone et al., 2018) 3.86571411168539 8.9515720027207 5.45633069436753 0.211546195377664 0.48986317795735 0.298590626664986 0 0 SMESG000062901.1 MSTRG.18805 SmMSTRG.18805 fer3l-3 Fer3-like protein 3 FER3 Basic domain 1 0 Mesenchyme (Cowles et al., 2013) 0.151629766322692 0.410122741123366 7.37935976497904 0.0190942730842901 0.0516455034324959 0.929260223483214 MA0668.1 5.89101E-11 SMESG000053680.1 MSTRG.16315 SMEST053680001 hesl-1 hesl-1 Hairy and enhancer of split like-1 HES Basic domain 1 No defect CNS, Mesenchyme (Cowles et al., 2013) 4.08615340034216 0.289948939118852 0.0799190801834233 0.916995906332113 0.0650690182593396 0.0179350754085469 0 0 SMESG000068772.1 MSTRG.19305 SmMSTRG.19305 hesl-2 hesl-2 Hairy and enhancer of split like-2 HES Basic domain 1 No defect Mesenchyme (Cowles et al., 2013) 10.9101822930126 1.66820445643876 2.28891403899942 0.733837463050982 0.112206276053462 0.153956260895555 MA1099.1 4.96093E-12 SMESG000009969.1 MSTRG.3741 SMEST009969001 hesl-3 hesl-3 Hairy and enhancer of split like-3 HES Basic domain 1 Brain defects CNS, Mesenchyme (Cowles et al., 2013; Roberts-Galbraith et al., 2016) 7.47991773255826 0.971340558575464 0.272824428356843 0.857387300540754 0.111340136242104 0.0312725632171417 MA0649.1 5.01841E-20 SMESG000070743.1 MSTRG.20842 SMEST070743001 ahr Aryl hydrocarbon receptor AHR Basic domain 1 No defect CNS, Epidermis, Mesenchyme (Cowles et al., 2013) 0.614527279147794 4.61612562775744 3.65116056122246 0.0691893926114323 0.519727828592929 0.411082778795638 0 0 SMESG000031846.1 MSTRG.10387 SMEST031846001 sim Single-minded SIM Basic domain 1 Brain defects CNS, Pharynx, Mesenchyme (Cowles et al., 2013) 8.55942941629528 2.69304284382886 1.20938208943508 0.686850381668763 0.216102898355903 0.0970467199753346 0 0 SMESG000047742.1 MSTRG.14630 SMEST047742003 npas Neuronal PAS domain-containing protein NPAS Basic domain 0 0 0 7.17649740525879 9.45148597642201 3.02712467386507 0.36512123896637 0.480866650527275 0.154012110506354 0 0 SMESG000035153.1 MSTRG.10887 SmMSTRG.10887 arnt-1 arnt Aryl hydrocarbon receptor nuclear translocator 1 MYOD Basic domain 1 No defect CNS, Mesenchyme (Cowles et al., 2013) 13.6912059240059 19.0325870715569 4.4401829142624 0.36839992462664 0.512124620835447 0.119475454537913 MA0259.1 4.94167E-141 SMESG000005948.1 MSTRG.1738 SmMSTRG.1738 arnt-2 Aryl hydrocarbon receptor nuclear translocator 2 MYOD Basic domain 0 0 0 7.29808108490571 7.88538639599567 7.18692211644382 0.326238443597415 0.352492135270253 0.321269421132331 0 0 SMESG000051880.1 MSTRG.13225 SMEST051880001 mitfl-1 mitfl-1 Microphthalmia-associated transcription factor like-1 MITF Basic domain 1 Lesions No detection (Cowles et al., 2013) 0.825242638794573 1.65670436151485 4.0797049379351 0.125767511986525 0.252482816386338 0.621749671627137 0 0 SMESG000077129.1 MSTRG.22605 SMEST077129001 mitfl-2 mitf Microphthalmia-associated transcription factor like-2 MITF Basic domain 1 0 CNS, Mesenchyme (Cowles et al., 2013, van Wolfswinkel et al., 2014) 14.7679603810628 16.0861023809518 11.9456914433564 0.345047784858764 0.375845672004657 0.279106543136579 MA0831.1 1.57113E-11 SMESG000009137.1 MSTRG.2717 SMEST009137002 mitfl-3 mitfl-3 Microphthalmia-associated transcription factor like-3 MITF Basic domain 1 0 CNS, Mesenchyme (Cowles et al., 2013) 26.5274188144985 9.97155848351739 13.0435809654099 0.5354470932536 0.201272579233737 0.263280327512663 MA0147.2 0.00120479 SMESG000064300.1 MSTRG.17507 SMEST064300001 usf Upstream transcription factor protein USF Basic domain 1 0 CNS, Mesenchyme (Cowles et al., 2013) 27.2568413155878 27.8417546391824 23.9886188297174 0.344642827413541 0.352038628684182 0.303318543902277 0 0 SMESG000056019.1 MSTRG.16922 SmMSTRG.16922 srebp Sterol regulatory element binding transcription factor SREBP Basic domain 1 0 CNS, Intestine, Mesenchyme (Cowles et al., 2013) 12.1813800871861 30.754107971422 17.7378812433791 0.200769797809582 0.506879844077075 0.292350358113344 MA0596.1 5.87204E-17 SMESG000062271.1 MSTRG.18571 SmMSTRG.18571 ap4-1 Activating enhancer binding protein-like-4-1 Ap4 Basic domain 1 0 CNS, Pharynx, Mesenchyme (Cowles et al., 2013) 4.09014155828362 6.36572447896589 6.06972853705693 0.247503443213043 0.385203960459199 0.367292596327758 MA0691.1 8.45064E-09 SMESG000081049.1 MSTRG.22708 SMEST081049001 ap4-2 ap4 Activating enhancer binding protein-like-4-2 Ap4 Basic domain 1 0 CNS, Pharynx, Intestine, Mesenchyme (Cowles et al., 2013; van Wolfswinkel et al., 2014) 18.8622954117794 34.7920013313487 6.14917358876614 0.315404696535141 0.581772280743272 0.102823022721587 0 0 SMESG000025391.1 MSTRG.372 SMEST025391001 mlx Max-like protein x MAX Basic domain 1 0 CNS, Pharynx, Intestine, Mesenchyme (Cowles et al., 2013) 73.6653323333079 87.4842477286725 60.6991695510388 0.332052051056432 0.394341856247895 0.273606092695673 MA0663.1 2.57566E-24 SMESG000062657.1 MSTRG.18688 SmMSTRG.18688 max MYC assciated factor X MAX Basic domain 1 CNS defects Ubiquitous (Cowles et al., 2013) 46.8152734479425 73.0377873164927 52.078464865288 0.272290222962165 0.424807417074801 0.302902359963034 0 0 SMESG000000528.1 MSTRG.1079 SMEST000528001 mlxipl Mlx interacting protein-like MAX Basic domain 1 0 CNS, Mesenchyme (Cowles et al., 2013) 6.36732648052212 13.6462977741708 8.51297595398857 0.223206636400518 0.478370982673842 0.298422380925639 0 0 SMESG000047681.1 MSTRG.14764 SmMSTRG.14764 mxi-1 Max-interactor-1 MAX Basic domain 1 Brain defect CNS, Pharynx, Intestine, Mesenchyme (Cowles et al., 2013) 17.6793239153386 41.8115298883166 24.6561392125124 0.21010048347113 0.496886797610024 0.293012718918846 0 0 SMESG000060394.1 MSTRG.17930 SMEST060394001 mxi-2 Max-interactor-2 MAX Basic domain 1 0 CNS, Pharynx, Intestine, Mesenchyme (Cowles et al., 2013) 4.90832401412687 10.8854918233074 24.4285792376564 0.122029630631482 0.270632611583309 0.607337757785209 0 0 SMESG000017492.1 MSTRG.6243 SMEST017492001 id4 Inhibitor of DNA binding 4 ID Basic domain 1 0 CNS, Mesenchyme (Cowles et al., 2013) 4.83408815099176 12.3745037742505 5.86705058654329 0.209488777984093 0.536258254474623 0.254252967541284 0 0 MSTRG.20970 SmMSTRG.20970 hlh-1 hlh-1 Helix-loop-helix 1 HLH Basic domain 1 0 CNS, Mesenchyme (Cowles et al., 2013; Roberts-Galbraith et al., 2016) 0.0976353470159796 3.41465920717473 3.02489336832641 0.0149353740741761 0.522343742852038 0.462720883073785 0 0 SMESG000069088.1 MSTRG.19091 SMEST069088001 coe coe Collier/olfactory/early B-cell factor HLH Basic domain 1 CNS defects CNS, Pharynx, Mesenchyme (Cowles et al., 2013) 3.67868593675471 11.5310762943863 2.70281914368782 0.205368833211504 0.643741739568035 0.150889427220461 MA0154.3 0 SMESG000022356.1 MSTRG.7890 SMEST022356001 ap2 TFAP-2b Transcription factor AP-2 Ap2 Basic domain 1 0 Neoblasts (Wenemoser et al., 2012; Roberts-Galbraith et al., 2016) 2.75350711599052 4.15141340569697 4.61234733883892 0.239076415460278 0.360451233397573 0.400472351142149 0 0 SMESG000080379.1 MSTRG.23513 SMEST080379001 e22/23 e22/23 Basic helix-loop-helix family, member e22/23-like e22 Basic domain 1 0 CNS, Mesenchyme (Cowles et al., 2013) 0.622723749877178 3.70344619226327 9.597692017486 0.0447234935022211 0.265978376042636 0.689298130455143 MA0817.1 1.72931E-35 SMESG000024492.1 MSTRG.8071 SMEST024492002 nr-1 nr1-like Nuclear receptor 1 NR Zinc 1 0 CNS (Scimone et al., 2014) 0.393885816752229 0.663796872988355 0.27520042081807 0.295514147963912 0.498015818288924 0.206470033747164 MA0676.1 1.91593E-55 SMESG000020242.1 MSTRG.7078 SmMSTRG.7078 nr1d2 Nuclear receptor subfamily 1, group D, member 2 NR Zinc 0 0 0 0.406316371740792 1.65558534129751 0.0715354978164461 0.190451525675792 0.776017842415999 0.0335306319082087 0 0 SMESG000066789.1 MSTRG.19780 SMEST066789003 nr2c1 Nuclear receptor subfamily 2, group C, member 1 NR Zinc 0 0 0 18.5480200942389 25.4643430886628 25.6804818866183 0.266139516556353 0.365379589013213 0.368480894430433 0 0 SMESG000017244.1 MSTRG.5439 SmMSTRG.5439 nr2c2 Nuclear receptor subfamily 2, group C, member 1 NR Zinc 0 0 0 7.75967006945868 11.6985329130518 12.6356427727713 0.241780624504362 0.36451016192494 0.393709213570698 0 0 SMESG000076268.1 MSTRG.22379 SMEST076268001 nr2e1 Nuclear receptor subfamily 2, group E, member 1 NR Zinc 0 0 0 0.0510912009519819 0.364333066128787 0.233289045248864 0.0787577501200112 0.56162415539217 0.359618094487819 MA0676.1 5.77866E-38 SMESG000056421.1 MSTRG.17044 SmMSTRG.17044 nr2f1 Nuclear receptor subfamily 2, group F, member 1 NR Zinc 0 0 0 0.0295762011225953 0.779956285001872 1.01848037387475 0.0161794272730707 0.42666892671762 0.557151646009309 MA0017.2 2.88614E-128 SMESG000023916.1 MSTRG.8468 SMEST023916001 nr2f6-1 Nuclear receptor subfamily 2, group F, member 6 protein 1 NR Zinc 0 0 0 0.80022415241905 0 0.29206121947359 0.732614546537847 0 0.267385453462153 0 0 SMESG000023925.1 MSTRG.8474 nr2f6-2 Nuclear receptor subfamily 2, group F, member 6 protein 2 NR Zinc 0 0 0 7.40614862860416 0.328966449625923 0.205565310356568 0.932684388009019 0.0414279927572396 0.0258876192337412 0 0 SMESG000063104.1 MSTRG.18823 SmMSTRG.18823 nr4a-1 NR4A Nuclear receptor subfamily 4, group A, protein 1 NR Zinc 1 Anterior and posterior blastema defects Anterior pole (Li et al., 2019) 10.2368994218262 13.9840002372303 10.7739869842579 0.292525577412663 0.39960124402637 0.307873178560967 MA0160.1 5.91522E-52 SMESG000023455.1 MSTRG.8332 SmMSTRG.8332 nr4a-2 Nuclear receptor subfamily 4, group A, protein 2 NR Zinc 0 0 0 0.010336709364734 0.416145846963015 4.62908085668011 0.0020446206525939 0.0823144352006901 0.915640944146716 MA0160.1 5.2746E-50 SMESG000033175.1 MSTRG.10809 SmMSTRG.10809 nr5a2 Nuclear receptor subfamily 5, group A, member 2 NR Zinc 0 0 0 162.507220142778 177.033382387482 128.418387224881 0.347268080538018 0.378309608882852 0.27442231057913 0 0 SMESG000078465.1 MSTRG.22967 SMEST078465001 nr6 nr6 Nuclear receptor subfamily 6 NR Zinc 1 (van Wolfswinkel et al., 2014) 19.7887320188071 15.7072297838605 7.06805902250195 0.464916886026551 0.369025986721919 0.16605712725153 0 0 SMESG000074066.1 MSTRG.20549 SmMSTRG.20549 nhr-48 Nuclear hormone receptor family member nhr-48 NR Zinc 0 0 0 3.94666828883348 0.900264139615871 2.29549918700879 0.552566478941406 0.126044488499891 0.321389032558703 0 0 SMESG000009304.1 MSTRG.2777 SMEST009304003 ror RAR-related orphan receptor ROR Zinc 1 0 CNS, Mesenchyme (van Wolfswinkel et al., 2014) 28.8189970931576 27.95998404525 26.5423583438391 0.345877745992046 0.335568105589654 0.318554148418299 0 0 SMESG000054304.1 MSTRG.16446 SMEST054304002 rar-b Retinoic acid receptor beta RAR Zinc 1 0 Ubiquitous (Cheng et al., 2018) 6.01020121231346 7.03953695943989 6.55106567637887 0.30663034326963 0.359145319446207 0.334224337284163 0 0 SMESG000041520.1 MSTRG.8960 SMEST041520002 rxra Retinoid X receptor alpha RXR Zinc 0 0 0 7.05071395781201 11.4573923277494 7.01088321194629 0.276292835125803 0.448975157455525 0.274732007418671 MA0016.1 1.17481E-59 SMESG000019911.1 MSTRG.7015 SMEST019911001 rxrg Retinoid X receptor gamma RXR Zinc 0 0 0 4.21242579379587 6.84088846121311 4.15166936303516 0.277042442110682 0.44991093927223 0.273046618617088 0 0 SMESG000014588.1 MSTRG.4403 SMEST014588001 hnf4 hnf4 Hepatocyte nuclear factor HNF4 Zinc 1 0 Intestine (Wagner et al., 2011; van Wolfswinkel et al., 2014; Zhu et al., 2015; Lobo et al., 2016; Fincher et al., 2018) 22.1493791256563 61.7809476346164 42.5555287642674 0.175113486277199 0.48844155244402 0.336444961278781 MA0484.1 1.93281E-110 SMESG000017206.1 MSTRG.5414 SmMSTRG.5414 tlx-1 tlx Nuclear receptor TLX 1 TLX Zinc 1 0 0 (Cowles et al., 2014; Scimone et al., 2018) 0.2097981868744 4.15298106178911 12.3126734792467 0.012581258829828 0.249047574872624 0.738371166297548 MA0170.1 2.17165E-39 SMESG000027543.1 MSTRG.9335 SMEST027543002 tlx-2 tlx-1 Nuclear receptor TLX 2 TLX Zinc 1 0 Epidermis DV boundary (Wurtzel et al., 2017) 2.7231579393583 4.53624155778541 2.55645803125266 0.277424354569171 0.462134005578472 0.260441639852358 MA0676.1 1.64772E-62 SMESG000077902.1 MSTRG.21681 SmMSTRG.21681 thrb Thyroid hormone receptor beta TH Zinc 0 0 0 7.33479595817744 14.7370495750238 7.36528671260218 0.249168155951166 0.500627895814299 0.250203948234535 0 0 SMESG000059170.1 MSTRG.15753 SMEST059170001 thrb Thyroid hormone receptor beta TH Zinc 0 0 0 28.5306662673873 27.3587116455831 10.4081871201671 0.430342596340104 0.41266540682012 0.156991996839775 0 0 SMESG000079514.1 MSTRG.23309 SmMSTRG.23309 gata123 GATA-binding factor 1/2/3 GATA Zinc 1 0 Neoblast, Subepidermis (van Wolfswinkel et al., 2014; Cheng et al., 2018) 8.20309001134427 2.88569354605193 1.05585852828026 0.675449301302926 0.237610423238026 0.0869402754590478 MA0037.2 3.99532E-61 SMESG000039559.1 MSTRG.12700 SmMSTRG.12700 gata456-1 GATA-binding factor 4/5/6-1 GATA Zinc 1 Dorsal lesions, gut defects Intestine (Wagner et al., 2011; van Wolfswinkel et al., 2014; Flores et al., 2016; Mihaylova et al., 2018; Fincher et al., 2018; Forsthoefel et al., 2020) 29.8923064312012 25.396314170756 15.8995156074693 0.419905731809888 0.356749249566574 0.223345018623537 MA0482.1 3.80402E-34 SMESG000022702.1 MSTRG.8018 SmMSTRG.8018 gata456-2 GATA-binding factor 45/6-2 GATA Zinc 1 Dorsal-ventral muscle defetcs Dorsal-ventral muscle, Intestinal muscle (González Sastre et al., 2017; Scimone et al., 2018) 10.8791180143861 6.48880872029292 9.03922001354786 0.411976277411212 0.245721689744032 0.342302032844756 MA0482.1 2.17679E-23 SMESG000028503.1 MSTRG.9120 SmMSTRG.9120 gata456-3 GATA-binding factor 4/5/6-3 GATA Zinc 1 Intestinal muscle defects Dorsal-ventral muscle, Intestinal muscle (Scimone et al., 2018) 1.20613997668708 3.86612304965187 3.07489088019609 0.148044334318958 0.474536641139276 0.377419024541766 MA0037.2 1.34883E-51 SMESG000037031.1 MSTRG.11935 SmMSTRG.12700 gata456-4 GATA binding protein 4/5/6-4 GATA Zinc 0 0 0 32.3993841225716 27.6473638119507 26.123067237471 0.375994587639571 0.320847430817474 0.303157981542955 MA0482.1 3.80402E-34 SMESG000039948.1 MSTRG.12511 SMEST039948001 gata GATA binding protein GATA Zinc 1 0 Ubiquitous (van Wolfswinkel et al., 2014) 9.36456638719911 5.54339186089166 4.56661419786743 0.480861205717646 0.284647679751354 0.234491114530999 0 0 SMESG000039508.1 MSTRG.12683 SmMSTRG.12683 rere Arginine-glutamic acid dipeptide repeats protein RERE Zinc 0 0 0 2.9564810164922 5.95045598677904 1.16161566667385 0.293635154267741 0.590994175810523 0.115370669921736 0 0 SMESG000081507.1 MSTRG.22679 SmMSTRG.22679 mta3 Metastasis-associated protein MTA3  MTA Zinc 0 0 0 81.0711883228479 75.3471805652866 18.0815267225608 0.464591615021453 0.431789258678894 0.103619126299653 0 0 SMESG000023227.1 MSTRG.7606 SmMSTRG.7606 sp5 Transcription factor Sp5 SP Zinc 1 0 Posterior expression (van Wolfswinkel et al., 2014; Cheng et al., 2018; Fincher et al., 2018; Tewari et al., 2019) 21.444085779408 13.6240266440029 14.26477181865 0.434681371439557 0.276165216230905 0.289153412329538 MA0746.1 1.57568E-45 SMESG000050160.1 MSTRG.15425 SmMSTRG.15425 sp6-9 Transcription factor Sp6-9 SP Zinc 1 Eye defects Optic pigment cup (Lapan and Reddien, 2011; Mihaylova et al., 2018) 7.51235221095134 3.27473936493857 3.77651303170624 0.515830552487879 0.224857750067625 0.259311697444496 MA0747.1 4.31066E-51 SMESG000067314.1 MSTRG.19918 SMEST067314001 sp8 Transcription factor Sp8 SP Zinc 0 0 0 0.621757770593868 1.880871031415 0.801949254972013 0.188150426430513 0.569171312943171 0.242678260626317 MA0747.1 1.12028E-39 - MSTRG.15979 SmMSTRG.15979 klf-1 klf Kruppel like factor 1 KLF Zinc 1 Eye defects Optic pigment cup (Lapan and Reddien, 2012) 0 0.11510753578426 0.444942685555758 0 0.205530738848464 0.794469261151536 MA0039.2 1.76631E-28 SMESG000025482.1 MSTRG.396 SmMSTRG.396 klf-2 klf Kruppel like factor 2 KLF Zinc 1 0 Ubiquitous (van Wolfswinkel et al., 2014; Zhu et al., 2015) 10.5746394829836 7.6492967205836 15.713215483051 0.311594784990553 0.225395955182644 0.463009259826803 MA0685.1 4.10182E-36 SMESG000032379.1 MSTRG.10177 SMEST032379001 klf-3 Kruppel like factor 3 KLF Zinc 0 0 0 1.1772388531183 0.931398886995641 4.22393237255816 0.185902221716033 0.147080706636287 0.66701707164768 MA0742.1 5.21241E-40 SMESG000034285.1 MSTRG.11197 SmMSTRG.11197 egr-1 Early growth response protein 1 EGR Zinc 1 0 Neoblasts (Wagner et al., 2012; Wenemoser et al., 2012; van Wolfswinkel et al., 2014; Zhu et al., 2015; Cheng et al., 2018) 43.4133441208001 201.340039676726 146.745447780756 0.110890098817879 0.514280052548426 0.374829848633695 MA0528.1 1.4879E-14 SMESG000004840.1 MSTRG.2271 SMEST004840001 egr-2 Early growth response protein 2 EGR Zinc 1 0 Neoblasts, Epidermis (van Wolfswinkel et al., 2014; Wurtzel et al., 2015; Owlarn et al., 2017) 30.8318507970843 5.95852429007643 34.4464764941376 0.432807600457999 0.0836438466581629 0.483548552883838 MA0452.2 7.897E-19 SMESG000005384.1 MSTRG.2484 SmMSTRG.2484 egr*-2 Early growth response protein 2* EGR Zinc 1 0 Ubiquitous (van Wolfswinkel et al., 2014) 49.7931478692745 73.3807843611218 35.5006676563641 0.313806670411079 0.462460812338526 0.223732517250395 MA0162.2 1.55796E-35 SMESG000000960.1 MSTRG.1218 SMEST000960001 egr4-1 egr-l1, egr-4 Early growth response protein 4-1 EGR Zinc 1 1 1 (Fraguas et al., 2014; Wurtzel et al., 2015; Zhu et al., 2015, Owlarn et al., 2017) 222.201440965464 72.9789090481827 551.199404970492 0.262531611439156 0.0862247810376209 0.651243607523223 MA0162.2 3.90749E-25 SMESG000028801.1 MSTRG.9193 SMEST028800001 egr4-2 egr-4 Early growth response protein 4-2 EGR Zinc 1 0 CNS (van Wolfswinkel et al., 2014; Wurtzel et al., 2015) 21.9234625821389 16.2805504271488 37.2839613577537 0.290423246430504 0.215670781520626 0.493905972048869 MA0162.2 1.08115E-30 SMESG000042500.1 MSTRG.8827 SmMSTRG.8827 egr4-3 Early growth response protein 4-3 EGR Zinc 0 0 0 1.73431219225363 6.30089852928261 40.1236911019075 0.0360122869622696 0.130835594058653 0.833152118979077 MA0443.1 2.64475E-17 SMESG000000959.1 MSTRG.1217 SMEST000959001 egr-5 Early growth response protein 5 EGR Zinc 1 Epidermal defects Neoblasts, Subepidermis (Tu et al., 2015; Cheng et al., 2018) 39.936002328287 8.90041426581007 112.438759896158 0.247626467987156 0.0551877508957361 0.697185781117108 MA0463.1 4.19407E-19 - MSTRG.10142 SmMSTRG.10142 osr-1 osr Odd-skipped-related 1 OSR Zinc 1 0 Tubule cells (Scimone et al., 2011; Cheng et al., 2018) 2.45722341489598 3.63342226215424 2.88479144769193 0.273772004721895 0.40481841849665 0.321409576781455 MA0454.1 2.15332E-42 SMESG000032229.1 MSTRG.10139 SmMSTRG.10142 osr-2 Odd-skipped-related 2 OSR Zinc 0 0 0 7.95055582176047 3.38301383945912 3.59956460066751 0.532410389026781 0.22654412530753 0.241045485665689 MA0454.1 2.15332E-42 SMESG000054738.1 MSTRG.16715 SMEST035995006 osr-3 Odd-skipped-related 3 OSR Zinc 0 0 0 0.119403972491841 0.34357454595454 0 0.257903915051017 0.742096084948983 0 0 0 SMESG000081129.1 MSTRG.22732 ovo-1 ovo Transcriptional regulator ovo 1 OVO Zinc 1 Eye defects Optic pigment cup (Lapan and Reddien, 2012; LoCascio et al., 2017; Fincher et al., 2018) 0.299887990189015 0.177669904644752 0.0231765332531928 0.598896287868058 0.354818631751634 0.0462850803803086 MA0528.1 3.18284E-13 SMESG000016051.1 MSTRG.5778 SmMSTRG.5778 ovo-2 Transcriptional regulator ovo 2 OVO Zinc 1 0 Epidermis (Wurtzel et al., 2017) 1.92294757952467 3.4526273318997 6.81009908879639 0.157803957293608 0.283334949863024 0.558861092843368 MA0126.1 1.05351E-46 SMESG000006550.1 MSTRG.1647 SMEST006550001 ovo-3 Transcriptional regulator ovo 3 OVO Zinc 1 0 0 (Wurtzel et al., 2017) 0.439296070837775 6.97522943509147 5.76641831101226 0.0333281195139566 0.529190438254216 0.437481442231827 MA0126.1 5.37894E-47 SMESG000073727.1 MSTRG.20466 SmMSTRG.20466 gli-1 gli-1 Zinc finger protein GLI1  GLI Zinc 1 Posterior defects Gut (Rink et al., 2009; Cheng et al., 2018; Scimone et al., 2018) 7.04901853799327 8.5277287043546 17.6892578749421 0.211898558697977 0.256349648065265 0.531751793236758 MA0734.1 1.28547E-77 SMESG000060276.1 MSTRG.17923 SMEST060276001 gli-2 gli-2 Zinc finger protein GLI2 GLI Zinc 1 0 0 (Rink et al., 2009) 1.95764538148349 0.115043065228842 0.12258606620887 0.891754252126991 0.0524048653376641 0.055840882535345 MA0734.1 3.87381E-69 SMESG000078300.1 MSTRG.22990 SMEST078300001 gli-3 gli-3 Zinc finger protein GLI3 GLI Zinc 1 0 0 (Rink et al., 2009) 0.210246128434095 1.37543079741674 1.21740201559481 0.0750054254004219 0.490685716010331 0.434308858589247 MA0737.1 3.45396E-72 SMESG000022958.1 MSTRG.7487 SMEST022958001 zic-1 zicA Zic family member 1 ZIC Zinc 1 Anterior defects Anterior pole (Vásquez-Doorman et al., 2014; Vogg et al., 2014; Fincher et al., 2018) 1.27797166944053 1.07996587864421 1.55977076270665 0.326203884531254 0.275662656065901 0.398133459402845 MA0697.1 1.97433E-84 SMESG000052644.1 MSTRG.16036 SMEST052644001 zic-2 zicB Zic family member 2 ZIC Zinc 1 Cyclops Anterior expression (Vásquez-Doorman et al., 2014; Fincher et al., 2018) 2.51092357010107 4.71294775308099 3.86116009480292 0.226514790569489 0.425163229166354 0.348321980264157 MA0697.1 6.15173E-82 SMESG000076673.1 MSTRG.22489 SMEST076673001 snail-1 snail-1 Zinc finger protein Snail 1 SNAI Zinc 1 Defective cell migration 0 (Abnave et al., 2017) 0.188082162013577 2.9321909169173 2.98416368908461 0.0308107314665037 0.480337667232572 0.488851601300924 MA0745.1 6.31126E-40 SMESG000064846.1 MSTRG.17678 SMEST064846001 snail-2 snail-like/snail Zinc finger protein Snail 2 SNAI ZInc 1 Defective cell migration Neoblasts (Scimone et al., 2014; Abnave et al., 2017; Wurtzel et al., 2017; Scimone et al., 2018) 9.39569930932496 7.22226589881642 14.2583605466151 0.304301081156897 0.233909499342027 0.461789419501076 MA0745.1 1.54596E-52 SMESG000041786.1 MSTRG.9027 SMEST041786001 scratch-like Transcriptional repressor scratch-like SCRT Zinc 1 0 0 (Scimone et al., 2014) 5.55563436904139 2.9960964342183 0.951349101772808 0.584614085597588 0.315276359260294 0.100109555142118 MA0743.1 1.79888E-75 SMESG000039253.1 MSTRG.12623 SmMSTRG.12623 yy2 Yy2 transcription factor YY Zinc 0 0 0 9.73298821008367 3.9063318459295 2.38236752575422 0.607488328580303 0.243815255165435 0.148696416254261 MA0095.2 4.96328E-49 SMESG000069311.1 MSTRG.19125 SmMSTRG.19125 prdm1-1 blimp1 PR domain zinc finger protein 1 PRDM Zinc 1 0 Epidermis (Wurtzel et al., 2017; Cheng et al., 2018) 3.32747281828316 12.8969870402056 6.09425216601657 0.149088926575588 0.577855345149176 0.273055728275236 MA0537.1 3.83086E-54 SMESG000037965.1 MSTRG.11704 SMEST037965001 prdm8 PR domain zinc finger protein 8 PRDM Zinc 0 0 0 0.360988098231667 0.486401837638542 0.486232419015398 0.270682398888425 0.364722318770866 0.364595282340708 0 0 SMESG000027218.1 MSTRG.308 SmMSTRG.308 prdm13 PR domain zinc finger protein 13 PRDM Zinc 0 0 0 0.34899325457459 1.02726769673999 0.483632721243529 0.187641508610857 0.552326034491574 0.260032456897569 MA0528.1 1.06478E-20 SMESG000053472.1 MSTRG.16138 SMEST053472002 prdm14 PR domain zinc finger protein 14 PRDM Zinc 0 0 0 0.0358322113623958 0.431605506039147 0.451153897463368 0.0390077710078655 0.469855699806947 0.491136529185187 MA0483.1 6.47336E-27 SMESG000072463.1 MSTRG.21308 SmMSTRG.21308 prdm15 PR domain zinc finger protein 15 PRDM Zinc 0 0 0 7.11288017377461 8.68041870167633 2.17365750861053 0.395886761326168 0.483132396835824 0.120980841838008 MA0146.2 1.09033E-09 SMESG000079499.1 MSTRG.23304 SMEST079499001 fezf2 FEZ Family Zinc Finger 2 FEZF Zinc 0 0 0 0.092390438012446 0.787246359095394 1.63145115197033 0.0367929916777159 0.313508078991974 0.64969892933031 MA0038.1 7.76176E-47 SMESG000042630.1 MSTRG.8862 SMEST042630001 gfi1 Growth factor independent 1 transcriptional repressor GFI Zinc 0 0 0 5.33861902109143 4.53625626473866 3.86416336387242 0.38857296767318 0.330172756653311 0.281254275673509 MA0038.1 3.60676E-80 SMESG000011176.1 MSTRG.4171 SMEST011176001 bcl11b B-cell lymphoma/leukemia 11B BCL Zinc 0 0 0 2.49047718527307 2.16672698463991 0.408062027961143 0.491677453461047 0.427761720706659 0.080560825832294 0 0 SMESG000042801.1 MSTRG.8925 SmMSTRG.8925 sall4 Sal-like protein 4 SALL Zinc 0 0 0 0.744211171074959 4.7522381508385 0.569691005003612 0.122682814931382 0.783403926505221 0.0939132585633969 MA0056.1 3.60844E-05 SMESG000014973.1 MSTRG.4514 SMEST014973001 ikzf1 Ikaros family zinc finger 4 IKZF Zinc 0 0 0 8.74320275164209 7.99426637706257 1.49420868969002 0.479561060629358 0.438482209739184 0.0819567296314578 MA0543.1 0.0117631 SMESG000014189.1 MSTRG.4288 SMEST014189001 hinfp-1 Histone H4 transcription factor 1 HINFP Zinc 0 0 0 23.347489873807 12.8562037081988 8.27336207672463 0.524933351095692 0.289052490498554 0.186014158405754 MA0139.1 5.71622E-13 SMESG000014197.1 MSTRG.4289 SmMSTRG.4289 hinfp-2 Histone H4 transcription factor 2 HINFP Zinc 0 0 0 4.90609774598808 0.50790716467488 1.715357168674 0.688153819569276 0.0712416004437408 0.240604579986984 MA0139.1 5.47299E-11 SMESG000027936.1 MSTRG.9440 SMEST027936001 rreb1 RREBP1 Ras-responsive element-binding protein 1 RREB Zinc 1 Anterior defects 0 (Mihaylova et al., 2018) 1.54981836410864 2.06569079196993 1.82680603367992 0.284771886609055 0.379561036056347 0.335667077334598 MA0698.1 1.32899E-09 SMESG000075452.1 MSTRG.22163 SmMSTRG.22163 rest-1 rest RE1-silencing transcription factor 1 REST Zinc 1 0 Epidermis (Cheng et al., 2018) 10.836892293534 38.2453703495251 12.9894779790085 0.174586570070846 0.616147863202151 0.209265566727003 MA0139.1 0.17717 SMESG000073676.1 MSTRG.20458 SMEST073676001 rest-2 RE1-silencing transcription factor 2 REST Zinc 0 0 0 2.35143836993072 15.8398107955699 9.38281875856848 0.0852771660824905 0.574445919230637 0.340276914686872 MA0531.1 6.37464E-10 SMESG000080385.1 MSTRG.23516 SmMSTRG.23516 dmd-1 Doublesex/male-abnormal-3 domain transcription factor 1 DMRT Zinc 1 Loss of male germ cells Testis, CNS (Chong et al., 2013) 3.15074102517737 12.3313152932364 0.620984976733953 0.195661239850808 0.765775549302737 0.0385632108464549 0 0 SMESG000075920.1 MSTRG.22289 SMEST075920001 dmd-2 Doublesex/male-abnormal-3 domain transcription factor 2 DMRT Zinc 1 0 0 (Chong et al., 2013) 0.484190498777946 0.461704374830838 0.556579482031421 0.322262071868529 0.307296010143285 0.370441917988186 0 0 SMESG000023052.1 MSTRG.7259 SmMSTRG.7259 dmd-3 Doublesex/male-abnormal-3 domain transcription factor 3 DMRT Zinc 1 0 0 (Chong et al., 2013) 6.36752635828229 3.47641302968602 1.41392727025804 0.565606837564505 0.308798561505943 0.125594600929552 0 0 SMESG000006521.1 MSTRG.1891 SMEST006521001 dmd-4 Doublesex/male-abnormal-3 domain transcription factor 4 DMRT Zinc 1 0 0 (Chong et al., 2013) 0.599268344350813 0.433499844053936 0.271720032835682 0.459389617010855 0.332314111385171 0.208296271603974 0 0 SMESG000002896.1 MSTRG.804 SmMSTRG.804 dmd-5 Doublesex/male-abnormal-3 domain transcription factor 5 DMRT Zinc 0 0 0 5.2473716261514 12.3004347956958 5.64552709837932 0.226244822529511 0.530343548285924 0.243411629184565 0 0 SMESG000080385.1 MSTRG.23516 SmMSTRG.23516 mab-3 Protein male abnormal 3 DMRT Zinc 0 0 0 3.15074102517737 12.3313152932364 0.620984976733953 0.195661239850808 0.765775549302737 0.0385632108464549 0 0 SMESG000068540.1 MSTRG.20349 SMEST068540001 myt1l Myelin transcription factor 1 like MYT1 Zinc 0 0 0 0.168964289530264 1.17875358079096 0.500852885990515 0.0914026628157749 0.637656728456965 0.27094060872726 0 0 SMESG000027385.1 MSTRG.9306 SmMSTRG.9306 st18 Suppression of tumorigenicity 18 protein ST18 Zinc 0 0 0 5.20685604475088 3.18544751381237 2.73928370092312 0.467755040083218 0.286162919946364 0.246082039970418 0 0 SMESG000025138.1 MSTRG.8252 SMEST025138001 l3mbtl4 Lethal(3)malignant brain tumor-like protein 4 L3MBTL4 Zinc 0 0 0 45.0698714053784 39.328131923532 29.1118947106329 0.397056751735232 0.346473149943552 0.256470098321216 0 0 SMESG000000679.1 MSTRG.1201 SMEST000679001 gl glass-like Protein glass GL Zinc 1 0 Neoblasts (Scimone et al., 2014) 0.125855879798036 0.94096402911149 0.179971871462678 0.100943783700968 0.75470823911799 0.144347977181042 MA0528.1 6.87663E-33 SMESG000032379.1 MSTRG.10215 SMEST032379001 cbt Transcription factor cabut CBT Zinc 0 0 0 1.07045609808426 1.08469075758959 0.0921240290642484 0.476336032898415 0.48267023123739 0.0409937358641944 MA0599.1 1.02282E-23 SMESG000041297.1 MSTRG.12851 SMEST041297001 nerfin2-1 Nervous fingers 2 protein 1 NERFIN Zinc 0 0 0 0.440988815739137 1.25214926125524 1.2775076957478 0.148448805234716 0.421507428702747 0.430043766062536 MA0155.1 5.03073E-22 SMESG000047651.1 MSTRG.14752 SMEST047651001 nerfin2-2 Nervous fingers 2 protein 2 NERFIN Zinc 0 0 0 0.701430065921455 0.208112509766656 0.128095928475469 0.67598692907687 0.200563596022693 0.123449474900437 0 0 SMESG000016937.1 MSTRG.5260 SMEST016937001 ctcf CCCTC-binding factor CTCF Zinc 0 0 0 0.452599664507672 0.733706948286207 0.22650424071865 0.320354039879025 0.51932425806474 0.160321702056235 MA0073.1 5.27511E-05 SMESG000018930.1 MSTRG.6059 SMEST018930001 eny2 Enhancer of yellow 2 homolog ENY Zinc 0 0 0 0.294760863649286 0 0 1 0 0 0 0 SMESG000052241.1 MSTRG.16105 SmMSTRG.16105 ccdc17 Coiled-coil domain-containing protein 17 CCDC Zinc 0 0 0 2.50033681025929 1.58063166014527 1.66853325810912 0.434878869217361 0.274916285755058 0.290204845027581 0 0 SMESG000012090.1 MSTRG.3565 SmMSTRG.3565 Xfin Zinc finger protein xfin Xfin Zinc 0 0 0 4.85309937474064 13.0910958431589 3.6334600978158 0.224913193937529 0.606696865420055 0.168389940642415 MA0163.1 3.59195E-12 SMESG000042352.1 MSTRG.8792 SMEST042352001 mzf1 Myeloid zinc finger 1 MZF Zinc 0 0 0 8.67447383181613 11.4041884181716 7.14333478440681 0.318656776755066 0.41893283596213 0.262410387282804 0 0 SMESG000057357.1 MSTRG.17155 SMEST057357001 atmin ATM interactor ATMIN Zinc 0 0 0 14.1806500406796 16.4119757095501 13.1412796132328 0.324248427457541 0.375268926320527 0.300482646221932 MA0740.1 0.0760194 SMESG000018020.1 MSTRG.6367 SMEST018020001 gm5141 Predicted gene 5141 GM Zinc 0 0 0 11.2390576061919 25.9607897742408 16.4572855317466 0.209460643836242 0.483827375136328 0.30671198102743 0 0 SMESG000062731.1 MSTRG.18725 SmMSTRG.18725 lin-28 Protein lin-28 homolog LIN Zinc 0 0 0 0.686555873429892 0.842005357526809 3.81188297133153 0.12855782167628 0.157665790640792 0.713776387682928 0 0 SMESG000050053.1 MSTRG.15562 SmMSTRG.19410 lin54-1 Protein lin-54 homolog 1 LIN Zinc 0 0 0 11.2577712788864 7.98122776681124 2.1445586117098 0.52646858204096 0.37324134246887 0.10029007549017 0 0 SMESG000065196.1 MSTRG.19410 SmMSTRG.19410 lin54-2 Protein lin-54 homolog 2 LIN Zinc 0 0 0 9.10307588895795 7.01304880356711 3.52049880425515 0.463576433619078 0.357141277609006 0.179282288771916 0 0 SMESG000017121.1 MSTRG.5364 SMEST017121002 hb-1 Hunchback 1 HB Zinc 1 Lysis, protonephridia loss Ubiquitous (Reddien et al., 2005; Scimone et al., 2011) 8.53414695640951 22.7908094110613 12.3537434492221 0.195384638101063 0.521783146172113 0.282832215726824 MA0049.1 1.17707E-50 SMESG000062486.1 MSTRG.18607 SMEST062486001 hb-2 Hunchback 2 HB Zinc 0 0 0 0.248784621188539 0.423126999827427 0.317099509545221 0.251548858754879 0.427828349704553 0.320622791540568 MA0049.1 8.01856E-50 SMESG000014324.1 MSTRG.4330 SmMSTRG.4330 fir1 Factor for initiating regeneration 1 FIR Zinc 1 Anterior and posterior blastema defects Neoblasts (Han et al., 2019) 253.982720135442 114.562248588012 43.1005687498075 0.616993741009374 0.27830314714745 0.104703111843177 MA0056.1 6.28466E-08 SMESG000003775.1 MSTRG.2029 SmMSTRG.2029 zmat1 Zinc finger matrin-type 1 ZMAT Zinc 0 0 0 85.9525377641069 42.2456964362668 38.333007694344 0.516134611056625 0.253680306203294 0.230185082740081 0 0 SMESG000022969.1 MSTRG.7498 SmMSTRG.7498 zmat3 Zinc finger matrin-type 3 ZMAT Zinc 0 0 0 37.5823155830073 42.4716233929017 26.3755475792692 0.353119391997844 0.39905880191278 0.247821806089376 0 0 SMESG000072403.1 MSTRG.21281 SmMSTRG.21281 zmat4 Zinc finger matrin-type 4 ZMAT Zinc 0 0 0 137.624706586786 181.48578170944 69.653540564786 0.354005762801652 0.466827608102404 0.179166629095944 0 0 SMESG000054487.1 MSTRG.16494 SmMSTRG.16494 zmat5 Zinc finger matrin-type 5 ZMAT Zinc 0 0 0 21.9943913766278 22.274673163379 10.8171980109162 0.399271803134142 0.404359855468281 0.196368341397577 0 0 SMESG000032173.1 MSTRG.10122 SmMSTRG.10122 zmym-1 ZMYM-1 Zinc finger MYM-type containing 1 ZMYM Zinc 1 Failed colony expansion 0 (Wagner et al., 2012) 43.8680550989606 29.3947024776245 7.2142074149006 0.545100763971426 0.365256101304695 0.0896431347238784 0 0 SMESG000043416.1 SMESG000043416.1 SMEST043416001 zmym-2 Zinc finger MYM-type containing 2 ZMYM Zinc 1 0 0 (Roberts-Galbraith et al., 2016) 0.0604627898796084 0.106697466963587 0.043266488049813 0.287334149992915 0.507052784653573 0.205613065353512 0 0 SMESG000070784.1 MSTRG.20851 SmMSTRG.20851 zmym-3 Zinc finger MYM-type containing 3 ZMYM Zinc 0 0 0 0.674696474913254 4.3012933378148 2.021867084459 0.0964147287985358 0.614658659216624 0.288926611984841 0 0 SMESG000066384.1 MSTRG.19740 SMEST066384001 zfp-1 Zinc finger protein 1 ZFP Zinc 1 Lesions, failed colony expansion Neoblasts (Wagner et al., 2012; van Wolfswinkel et al., 2014; Wurtzel et al., 2015; Wurtzel et al., 2017; Cheng et al., 2018; Fincher et al., 2018; Mihaylova et al., 2018; Raz et al., 2021) 113.659003237853 26.8982746488052 10.4428988902683 0.752707749513182 0.178134060654394 0.0691581898324242 0 0 SMESG000022971.1 MSTRG.7499 SMEST022971001 zfp-2 Zinc finger protein 2 ZFP Zinc 1 0 Posterior photoreceptors (Lapan and Reddien, 2012) 3.22728860033372 0.254332105783721 0.0147044866906542 0.923051610580223 0.0727426917572997 0.0042056976624775 MA0130.1 2.8853E-26 SMESG000004948.1 MSTRG.2385 SMEST004948001 zfp-3 Zinc finger protein 3 ZFP Zinc 1 0 0 (Stückemann et al., 2017) 0.689445052546779 2.18028417710532 0.386710189373562 0.211717450820278 0.669530089940279 0.118752459239443 MA0537.1 0.0417532 SMESG000020158.1 MSTRG.7049 SmMSTRG.7049 zfp-4 Zinc finger protein 4 ZFP Zinc 1 Loss of neoblasts Ubiquitous (Roberts-Galbraith et al., 2016) 20.5126398948511 14.9280823846237 1.76676434510862 0.551304099140578 0.401211792004263 0.0474841088551596 MA0163.1 0.0713701 SMESG000000595.1 MSTRG.1175 SMEST000595001 zfp-5 Zinc finger protein 5 ZFP Zinc 0 0 0 1.13756049667274 0.104326715762532 0 0.915993405264273 0.0840065947357271 0 0 0 SMESG000009964.1 MSTRG.3737 SmMSTRG.3737 zfp-6 Zinc finger protein 6 ZFP Zinc 0 0 0 33.8938422257668 46.6108864074809 12.259016477768 0.365378113887102 0.502468786180409 0.132153099932489 MA0698.1 6.86246E-16 SMESG000047505.1 MSTRG.14619 SMEST047505001 zfp-7 Zinc finger protein 7 ZFP Zinc 0 0 0 3.28369395773912 6.18265147082572 3.61040111213477 0.251109398466894 0.472797377511528 0.276093224021578 MA0138.2 1.11809E-09 SMESG000048367.1 MSTRG.14931 SmMSTRG.14931 zfp-8 Zinc finger protein 8 ZFP Zinc 0 0 0 35.3676474399149 55.0566752909661 8.54012717867074 0.35737729530391 0.556327806007965 0.0862948986881244 MA0056.1 2.21204E-25 SMESG000072526.1 MSTRG.21226 zfp-9 Zinc finger protein 9 ZFP Zinc 0 0 0 0.14033359977082 1.76413675316436 6.45793837123081 0.0167814805996361 0.21096035979039 0.772258159609973 0 0 SMESG000080376.1 MSTRG.23512 SMEST080376001 zfp-10 Zinc finger protein 10 ZFP Zinc 0 0 0 2.82829121672109 4.43687223819781 1.6616917739943 0.31682951545585 0.497025226064742 0.186145258479407 MA0073.1 1.61233E-06 SMESG000047572.1 MSTRG.14621 SmMSTRG.14621 zfp112 Zinc finger protein 112 ZFP Zinc 0 0 0 12.0905924905428 21.6302970408288 18.5746423502985 0.231197428451448 0.413616541653539 0.355186029895013 MA0146.2 1.20134E-23 SMESG000038394.1 MSTRG.12358 SmMSTRG.16707 zfp236-1 Zinc finger protein 236 protein 1 ZFP Zinc 0 0 0 5.42773146731288 8.23468816966619 1.37078000934721 0.361049649775607 0.547766833634683 0.0911835165897096 MA0056.1 1.14052E-24 SMESG000054710.1 MSTRG.16707 SmMSTRG.16707 zfp236-2 Zinc finger protein 236 protein 2 ZFP Zinc 0 0 0 2.76733449120928 3.80458681515265 0.721173694538684 0.379445830729964 0.521669718368241 0.0988844509017949 MA0130.1 6.35051E-22 SMESG000042947.1 MSTRG.13661 SmMSTRG.13661 zfp257 Zinc finger protein 257 ZFP Zinc 0 0 0 29.1499539369313 52.7217915529102 21.7099246839239 0.281420003056818 0.508987656449889 0.209592340493294 0 0 SMESG000065210.1 MSTRG.19417 SmMSTRG.19417 zfp354 Zinc finger protein 354 ZFP Zinc 0 0 0 25.8373942904278 29.4117305965686 14.0447428246298 0.372866967073521 0.424449256014523 0.202683776911956 MA0056.1 4.75256E-07 SMESG000010233.1 MSTRG.3909 SMEST010233001 zfp362 Zinc finger protein 362 ZFP Zinc 0 0 0 12.8703791919599 8.66614418082525 6.45133030560633 0.459855883907837 0.309639470050399 0.230504646041764 MA0543.1 1.31386E-16 SMESG000010914.1 MSTRG.4068 SMEST010914001 zfp408 Zinc finger protein 408 ZFP Zinc 0 0 0 1.30296533358808 4.39747093424048 4.52466940523758 0.127428055537872 0.43006606238054 0.442505882081588 MA0146.2 0.000734633 SMESG000015209.1 MSTRG.5535 SMEST015209001 zfp541 Zinc finger protein 541 ZFP Zinc 0 0 0 6.12660566478138 13.4290580309332 5.76721059544046 0.241939583727323 0.530313339494159 0.227747076778518 MA0038.1 4.38108E-17 SMESG000075268.1 MSTRG.22126 SMEST075268001 zfp560-1 Zinc finger protein 560 protein 1 ZFP Zinc 0 0 0 10.0022637427003 13.8515809172157 4.67393628230549 0.350614853744084 0.485547086374153 0.163838059881763 MA0015.1 1.8682E-15 SMESG000075372.1 MSTRG.22089 SMEST075372001 zfp560-2 Zinc finger protein 560 protein 2 ZFP Zinc 0 0 0 12.887411699026 9.44678786381464 7.00340603909283 0.43927960154242 0.322002688017323 0.238717710440257 MA0130.1 3.08551E-18 SMESG000055679.1 MSTRG.16827 SMEST055679001 zfp674 Zinc finger protein 674 ZFP Zinc 0 0 0 1.35628720244862 5.16505268930339 5.63448904729687 0.111575048419096 0.424903370654665 0.46352158092624 MA0139.1 1.24315E-16 SMESG000029867.1 MSTRG.9977 SmMSTRG.9977 zfp677 Zinc finger protein 677 ZFP Zinc 0 0 0 13.1475645340251 14.970630512588 12.1759902340319 0.326289375066244 0.371533272315075 0.302177352618681 MA0073.1 1.04942E-14 SMESG000075102.1 MSTRG.22069 SMEST075102001 zfp878 Zinc finger protein 878 ZFP Zinc 0 0 0 48.3094435488211 39.5951931632139 35.1787975062922 0.392493464743022 0.321693925869662 0.285812609387316 MA0537.1 5.94272E-15 SMESG000030062.1 MSTRG.9571 SMEST030062001 znf-1 Zinc finger 1 ZNF Zinc 0 0 0 28.4620749522733 22.1598661432428 4.23391582510808 0.518852070681489 0.4039653628109 0.0771825665076112 MA0139.1 4.28342E-05 SMESG000026243.1 MSTRG.624 SMEST026243001 znf91 Zinc finger 91 ZNF Zinc 1 0 Neoblasts (Wurtzel et al., 2015; Molinaro et al., 2016) 13.2219732439268 33.1145168068152 17.9495137604258 0.205674213048998 0.515112385957059 0.279213400993943 MA0139.1 2.61367E-06 SMESG000025574.1 MSTRG.432 SmMSTRG.432 znf101 Zinc finger 101 ZNF Zinc 0 0 0 1.52993695500941 3.67039138952509 0.420759993022739 0.272178066440826 0.652968103169881 0.0748538303892923 MA0056.1 5.64363E-07 SMESG000009146.1 MSTRG.2722 SMEST009146001 znf143 Zinc finger 143 ZNF Zinc 0 0 0 15.0721590292507 12.9320569151484 7.37607020394915 0.426004441175339 0.365515893820778 0.208479665003883 MA0696.1 3.36149E-07 SMESG000064097.1 MSTRG.17449 SmMSTRG.17449 znf180 Zinc finger 180 ZNF Zinc 0 0 0 11.4804767803919 17.7179074708714 13.8789749210609 0.266508370080582 0.411304402389053 0.322187227530365 MA0533.1 1.13091E-22 SMESG000017103.1 MSTRG.5349 SmMSTRG.5349 znf181 Zinc finger 181 ZNF Zinc 0 0 0 8.46141882370531 1.85101928500983 2.96421454429373 0.637315673223379 0.139419124186422 0.223265202590199 MA0508.1 3.36966E-15 SMESG000077995.1 MSTRG.21518 SmMSTRG.21518 znf207 znf207-1 Zinc finger 207 ZNF Zinc 1 Tissue maintenance defects 0 (Wagner et al., 2012) 123.264940851475 116.73393258559 67.1043036961324 0.401379568919316 0.380113073642869 0.218507357437816 MA0695.1 1.88544E-13 SMESG000024007.1 MSTRG.8490 SMEST024007001 znf208 Zinc finger 208 ZNF Zinc 0 0 0 1.22572708420961 0.804207079253184 0.996177142412389 0.405050231242277 0.265755948134432 0.329193820623291 0 0 SMESG000036361.1 MSTRG.11386 SMEST036361001 znf333-1 Zinc finger 333 protein 1 ZNF Zinc 0 0 0 0.454379657180441 1.2629638522111 0.202483430659267 0.23667740445835 0.657852968860659 0.105469626680991 MA0139.1 2.76649E-13 SMESG000068480.1 MSTRG.20330 znf333-2 Zinc finger 333 protein 2 ZNF Zinc 0 0 0 0.110666733209765 0.171751379577961 0.015606538747516 0.371334158566001 0.576299237976464 0.0523666034575349 MA0694.1 2.19208E-09 SMESG000042841.1 MSTRG.8933 SmMSTRG.8933 znf341 Zinc finger 341 ZNF Zinc 0 0 0 8.06545727711748 11.1656731813915 5.48862739995931 0.326275739564111 0.451690232781404 0.222034027654485 MA0528.1 1.08029E-15 SMESG000014806.1 MSTRG.4483 SMEST014806001 znf362 Zinc finger 362 ZNF Zinc 0 0 0 0.46543237874505 1.86291021477688 1.53733933882763 0.120401105649724 0.481909853779565 0.397689040570711 MA0463.1 9.04801E-29 SMESG000072474.1 MSTRG.21315 SMEST072474002 znf425 Zinc finger 425 ZNF Zinc 0 0 0 85.3010039326941 131.634893540008 105.747142789208 0.264349201195881 0.407938680115213 0.327712118688906 MA0056.1 7.22592E-11 SMESG000067419.1 MSTRG.20054 SmMSTRG.20054 znf486 Zinc finger 486 ZNF Zinc 0 0 0 8.49705083513376 17.1848748967969 5.52674696623921 0.272265690928664 0.550644209159354 0.177090099911981 MA0146.2 0.000536268 SMESG000000518.1 SMESG000000518.1 SMEST000518001 znf551 Zinc finger 551 ZNF Zinc 0 0 0 0.865007043092348 0.252866291133079 0.267932444902126 0.624190673845307 0.182468780937162 0.193340545217531 0 0 SMESG000000427.1 MSTRG.1123 SMEST000427001 znf595 Zinc finger 595 ZNF Zinc 0 0 0 0.166359805627747 0.0854216165460594 0.359081305091513 0.272335826368877 0.139837663575368 0.587826510055755 0 0 SMESG000022366.1 MSTRG.7896 SmMSTRG.7896 znf596 Zinc finger 596 ZNF Zinc 1 0 0 (Fincher et al., 2018) 13.6392179795863 11.7595464711278 12.7619416415755 0.357415241389942 0.308158513699614 0.334426244910444 MA0277.1 3.02198E-14 SMESG000065334.1 MSTRG.19447 SMEST065334001 znf622 Zinc finger 622 ZNF Zinc 0 0 0 95.5774841984543 54.0562170250213 61.4082841910764 0.452883742591363 0.256139634579527 0.290976622829109 0 0 SMESG000075339.1 MSTRG.22087 SMEST075339001 znf652 Zinc finger 652 ZNF Zinc 0 0 0 11.1013107708664 5.02530595259775 2.31813313050678 0.601868328860877 0.272451835475333 0.12567983566379 MA0139.1 1.80263E-12 SMESG000018550.1 MSTRG.6529 SMEST018550001 znf660 Zinc finger 660 ZNF Zinc 0 0 0 8.17897026413821 10.8146877358611 6.40776017126067 0.321988725550457 0.425751336517786 0.252259937931758 MA0056.1 4.41075E-34 - MSTRG.1069 SmMSTRG.1069 znf799 Zinc finger 799 ZNF Zinc 0 0 0 3.63224753557089 0.260848723937808 0.229509139433009 0.881056318536648 0.0632727847309298 0.0556708967324218 MA0130.1 0.0172151 SMESG000065225.1 MSTRG.19418 SmMSTRG.19418 zbed-1 Zinc finger BED domain-containing protein 1 ZBED Zinc 0 0 0 9.84383871390504 8.01147392485301 4.18207276888751 0.446688140712457 0.363540128588646 0.189771730698897 MA0163.1 0.000615028 SMESG000077712.1 MSTRG.21614 SMEST077712001 zbed-2 Zinc finger BED domain-containing protein 2 ZBED Zinc 0 0 0 0.192624882213903 0.0661414460444455 0 0.744397014520333 0.255602985479667 0 0 0 SMESG000074376.1 MSTRG.21828 SmMSTRG.21828 zbed-3 Zinc finger BED domain-containing protein 3 ZBED Zinc 0 0 0 30.663166403355 22.3408041860362 16.5572336430737 0.44080844691651 0.321167588062104 0.238023965021386 0 0 SMESG000010119.1 MSTRG.3814 SMEST010119002 zbed-4 Zinc finger BED domain-containing protein 4 ZBED Zinc 0 0 0 5.01105896725188 5.12681616957349 3.25844434803873 0.374062366377097 0.382703336940124 0.243234296682779 0 0 SMESG000005754.1 MSTRG.1684 SMEST005754001 zbed1 Zinc finger BED domain-containing 1 ZBED Zinc 0 0 0 0.335753666996534 0.4141998894928 0.788833384925861 0.218193732972381 0.269172994873395 0.512633272154224 MA0537.1 1.40601E-55 SMESG000045018.1 SMESG000045018.1 SMEST045018001 zbed4 Zinc finger BED domain-containing 4 ZBED Zinc 0 0 0 0.307548820121799 0.307523231117019 0.137355505561428 0.408742100607895 0.40870809201192 0.182549807380185 0 0 SMESG000032275.1 MSTRG.10151 SMEST032275001 zbed5-1 Zinc finger BED domain-containing 5 protein 1 ZBED Zinc 0 0 0 0.269267946452164 0.319843728191939 0.16912973087116 0.355121659795383 0.421823084133198 0.22305525607142 0 0 SMESG000020077.1 MSTRG.7064 SMEST020077001 zbed5-2 Zinc finger BED domain-containing 5 protein 2 ZBED Zinc 0 0 0 0.222147420180961 2.66509893239518 1.76704475891871 0.0477295929410853 0.572611138528293 0.379659268530622 0 0 SMESG000057001.1 MSTRG.17183 SmMSTRG.17183 zbed8 Zinc finger BED domain-containing 8 ZBED Zinc 0 0 0 9.50015810868183 24.4805987252746 14.7496857744476 0.194953248937727 0.502367666183534 0.302679084878739 MA0095.2 9.09331E-73 SMESG000028779.1 SMESG000028779.1 SMEST028779001 zbed9 Zinc finger BED domain-containing 9 ZBED Zinc 0 0 0 0.962464655427064 1.22207180247763 0 0.440580724548866 0.559419275451134 0 0 0 SMESG000055576.1 MSTRG.16801 SMEST055576001 zfand1 AN1-type zinc finger protein 1 ZFAND Zinc 0 0 0 85.2944194288011 67.7194922016913 124.401557857624 0.307460934266518 0.244108565130295 0.448430500603187 0 0 SMESG000067619.1 MSTRG.20090 SmMSTRG.20090 zfand5 AN1-type zinc finger protein 5 ZFAND Zinc 0 0 0 170.588812282672 153.251108674143 176.322447032349 0.341066867882327 0.306402717362101 0.352530414755573 0 0 SMESG000017254.1 MSTRG.5444 SmMSTRG.5444 zfand6 AN1-type zinc finger protein 6 ZFAND Zinc 0 0 0 35.0452474721696 41.741558581428 35.4568465922546 0.312224759672988 0.371883465990988 0.315891774336024 0 0 SMESG000018039.1 MSTRG.6378 SmMSTRG.6378 zbtb24 Zinc finger and BTB domain-containing protein 24 ZBTB Zinc 0 0 0 10.6579926998116 15.5584445116059 22.1998361909393 0.220132446197166 0.321347419333776 0.458520134469058 MA0508.1 3.06682E-16 SMESG000031886.1 MSTRG.10038 SmMSTRG.10038 zscan-like-1 Zinc finger and SCAN domain-containing protein-like 1 ZSCAN-LIKE Zinc 0 0 0 50.0802442566235 38.5975534601226 15.6917811586238 0.479835645561294 0.369816127228153 0.150348227210553 MA0130.1 4.16225E-20 SMESG000031902.1 MSTRG.10044 SMEST031902003 zscan-like-2 Zinc finger and SCAN domain-containing protein-like 2 ZSCAN-LIKE Zinc 0 0 0 3.35284040362863 0.534951807519236 0.372803616751631 0.786941671789977 0.125557980415845 0.0875003477941781 MA0139.1 3.29802E-16 SMESG000049972.1 MSTRG.15548 SMEST031902003 zscan-like-3 Zinc finger and SCAN domain-containing protein-like 3 ZSCAN-LIKE Zinc 0 0 0 22.250132337343 3.20362538946709 1.11061729235174 0.837592916125193 0.120598560559253 0.0418085233155536 MA0533.1 8.98149E-21 SMESG000049967.1 SMESG000049967.1 SMEST049970001 zscan-like-4 Zinc finger and SCAN domain-containing protein-like 4 ZSCAN-LIKE Zinc 0 0 0 0.570048811309934 0.153977629095553 0.0398522540786576 0.746255675706329 0.201573404530592 0.0521709197630786 MA0740.1 1.32813E-15 SMESG000049970.1 SMESG000049970.1 SMEST049970001 zscan-like-5 Zinc finger and SCAN domain-containing protein-like 5 ZSCAN-LIKE Zinc 0 0 0 0.39072717256357 0.155472883297979 0.070671138284091 0.633401553309234 0.25203459777905 0.114563848911716 MA0015.1 6.42066E-15 SMESG000014054.1 MSTRG.5025 SMEST014054001 zscan-like-6 Zinc finger and SCAN domain-containing protein-like 6 ZSCAN-LIKE Zinc 0 0 0 33.0120776926399 22.0632044235736 13.1865254301901 0.483609779453886 0.323214476976387 0.193175743569727 MA0139.1 2.27396E-18 SMESG000061747.1 SMESG000061747.1 SMEST061747001 zscan-like-7 Zinc finger and SCAN domain-containing protein-like 7 ZSCAN-LIKE Zinc 0 0 0 0 0.0420745021026769 0.0483167669852632 0 0.465470863803708 0.534529136196292 MA0537.1 2.95024E-10 SMESG000031904.1 SMESG000031904.1 SMEST049970001 zscan-like-8 Zinc finger and SCAN domain-containing protein-like 8 ZSCAN-LIKE Zinc 0 0 0 0.0487953318012915 0 0 1 0 0 MA0015.1 7.70302E-15 SMESG000055233.1 MSTRG.16706 SmMSTRG.16706 zf-1 Zinc finger 1 ZF Zinc 0 0 0 4.77163632395138 6.56294544991909 2.53660709857197 0.343996204494849 0.473135036244625 0.182868759260526 0 0 SMESG000059614.1 MSTRG.17842 SmMSTRG.17842 zf-2 Zinc finger 2 ZF Zinc 0 0 0 13.3523174017739 29.4623736495133 4.23736775277048 0.283777537926192 0.626165451594915 0.0900570104788924 MA0698.1 2.51779E-09 SMESG000067728.1 MSTRG.20132 SmMSTRG.20132 zf-3 Zinc finger 3 ZF Zinc 0 0 0 10.4261055866294 28.7810425092775 30.2505793095153 0.150107208745438 0.4143677540914 0.435525037163162 0 0 SMESG000060422.1 MSTRG.17936 SmMSTRG.17936 zf-4 Zinc finger 4 ZF Zinc 0 0 0 0.637838538162378 7.80026336160373 2.31492293766464 0.0593171268369151 0.725401780385683 0.215281092777402 MA0463.1 1.87084E-21 SMESG000071581.1 MSTRG.20936 SMEST071581001 zf-5 Zinc finger 5 ZF Zinc 0 0 0 2.73570668731798 1.38591083046249 1.23213793068819 0.510988354557823 0.258867040865473 0.230144604576704 MA0163.1 8.14983E-06 SMESG000026829.1 MSTRG.221 SMEST026829001 zf-6 Zinc finger 6 ZF Zinc 0 0 0 7.08974259337489 82.1938074163649 87.6340451796654 0.0400736997684414 0.464588088756065 0.495338211475494 MA0015.1 1.81301E-12 SMESG000022723.1 MSTRG.7329 SmMSTRG.7329 zf-7 Zinc finger 7 ZF Zinc 0 0 0 44.3262761119067 81.9907657290503 19.2573069337999 0.304492353803976 0.56322261730267 0.132285028893354 0 0 SMESG000030429.1 MSTRG.9645 SMEST030429001 zf-8 Zinc finger 8 ZF Zinc 0 0 0 16.3266325132501 22.4675485252749 7.31480860828397 0.354087839232886 0.487270458480536 0.158641702286578 MA0698.1 8.1865E-15 SMESG000040582.1 MSTRG.12959 SMEST040582001 pogo-1 Pogo transposable element 1 POGO Zinc 0 0 0 3.05302038053906 3.88871586672531 9.18454472501703 0.189319557670286 0.241141517589171 0.569538924740543 0 0 SMESG000052069.1 MSTRG.13271 SMEST052069001 pogo-2 Pogo transposable element 2 POGO Zinc 0 0 0 0.191003859676386 0.308868982524183 0.0650621038794724 0.338098857225455 0.546733716275398 0.115167426499146 0 0 SMESG000062992.1 MSTRG.18657 SMEST062992001 pogo-3 Pogo transposable element 3 POGO Zinc 0 0 0 0.246401413031942 0.0996641018676164 0 0.712007993929869 0.287992006070131 0 0 0 SMESG000055010.1 MSTRG.16625 SMEST055010001 pogo-4 Pogo transposable element 4 POGO Zinc 0 0 0 0.615877215632633 1.33494499594329 0.315386774435707 0.271765410619316 0.589065264582107 0.139169324798577 0 0 SMESG000009320.1 MSTRG.2780 SMEST009320001 pogo-5 Pogo transposable element 5 POGO Zinc 0 0 0 105.782964572488 117.871072312022 134.082000950866 0.29570116897523 0.329491747673082 0.374807083351688 0 0 SMESG000080661.1 MSTRG.23578 SMEST080661001 hox1 Homeobox protein 1 HOX Helix-turn-helix 1 Fission defects CNS (Currie et al., 2016; Stückemann et al., 2017) 0.0198687364718512 0.314671042429253 0.230690104554321 0.035151603008651 0.556713386251929 0.40813501073942 MA0904.1 1.28308E-15 SMESG000029666.1 MSTRG.9913 SmMSTRG.9913 hox3a Hox2/3a Homeobox protein 2/3a HOX Helix-turn-helix 1 Fission defects CNS (Currie et al., 2016) 0.105873310261338 1.29703328827969 2.36226698522843 0.0281191047121242 0.344481671142817 0.627399224145059 MA0912.1 4.46243E-22 SMESG000025656.1 MSTRG.442 SmMSTRG.442 hox3b Xlox Homeobox protein 3b HOX Helix-turn-helix 1 Fission defects Anterior axially restricted (Currie et al., 2016; Stückemann et al., 2017) 1.64565354585944 0.765388044008876 0.190008415025075 0.632688161612983 0.294261180126849 0.0730506582601678 0 0 SMESG000071019.1 MSTRG.20904 SMEST071019001 hox4a Homeobox protein 4a HOX Helix-turn-helix 1 No fission defect CNS (Currie et al., 2016) 2.3556511206614 2.42256344726652 2.45002054451 0.325895752423428 0.33515282909073 0.338951418485842 MA0904.1 7.00419E-30 SMESG000044469.1 MSTRG.13843 SmMSTRG.13843 hox4b hoxD Homeobox protein 4b HOX Helix-turn-helix 1 No fission defect CNS, Pharynx, Posterior axially restricted (Currie et al., 2016; Roberts-Galbraith et al., 2016; Fincher et al., 2018; Tewari et al., 2019) 0.258137116382228 5.22273516213379 7.14172631570365 0.0204503941447079 0.413760694610495 0.565788911244797 MA0158.1 3.94709E-31 SMESG000043155.1 MSTRG.13724 SMEST043155001 lox4 Lophotrochozoan hox 4 HOX Helix-turn-helix 1 No fission defect Mesenchyme (Currie et al., 2016) 0.808149755294019 2.5182130707971 0.943171696412666 0.189282871712229 0.589809745658256 0.220907382629515 MA0206.1 2.55353E-35 SMESG000022667.1 MSTRG.7998 SMEST022667001 lox5a Lophotrochozoan hox 5a HOX Helix-turn-helix 1 No fission defect Posteior axially restricted (Currie et al., 2016; Cheng et al., 2018; Fincher et al., 2018; Tewari et al., 2019) 2.64255353168915 3.32688713513962 7.2922562585903 0.199262096438359 0.250864361766772 0.549873541794868 MA0166.1 3.55309E-34 SMESG000079807.1 MSTRG.23420 lox5b Plox6 Lophotrochozoan hox 5b HOX Helix-turn-helix 1 Fission defects Mesenchyme (Currie et al., 2016; Stückemann et al., 2017) 0.0672141075971627 0.586331094310012 0.232823125598869 0.0758308995384364 0.661498246400297 0.262670854061266 MA0166.1 2.02019E-33 SMESG000003389.1 MSTRG.934 SMEST003389001 post-1 Post-1 HOX Helix-turn-helix 1 No fission defect Primordial germ cells (Currie et al., 2016) 0.313160546654024 0.313068854039169 0.0392010355629432 0.47061350006161 0.470475705620809 0.0589107943175806 0 0 SMESG000054107.1 MSTRG.16300 SmMSTRG.16300 post-2a Post-2a HOX Helix-turn-helix 1 No fission defect Radial expression (Currie et al., 2016; Wurtzel et al., 2017; Cheng et al., 2018) 1.49355628481805 7.1073185922307 2.38449208496389 0.13595870670345 0.646980534815795 0.217060758480755 0 0 SMESG000033048.1 MSTRG.10796 SMEST033048001 post-2b abdBb Post-2b HOX Helix-turn-helix 1 Fission defects Radial expression, CNS (van Wolfswinkel et al., 2014; Currie et al., 2016; Wurtzel et al., 2017; Cheng et al., 2018) 13.7728524063886 25.4329398489312 5.05266993326055 0.311191390873547 0.574645809892 0.114162799234453 0 0 SMESG000022668.1 MSTRG.7999 SmMSTRG.7999 post-2c abdBa Post-2c HOX Helix-turn-helix 1 No fission defect Pharynx, Posterior axially restricted (Currie et al., 2016; Roberts-Galbraith et al., 2016; Stückemann et al., 2017; Fincher et al., 2018; Tewari et al., 2019) 30.7898688685992 28.4509493876307 28.8022609867237 0.349713675774958 0.323148050162134 0.327138274062908 0 0 - MSTRG.9883 SmMSTRG.9883 post-2d abdBa Post-2d HOX Helix-turn-helix 1 No fission defect CNS, Posterior axially restricted (van Wolfswinkel et al., 2014; Currie et al., 2016; Cheng et al., 2018; Tewari et al., 2019) 10.0632717801428 5.04970207382589 2.33943475075809 0.576612203396228 0.289341270204861 0.134046526398911 0 0 SMESG000015136.1 MSTRG.5503 SmMSTRG.5503 eve Eve Even-skipped EVX Helix-turn-helix 1 0 0 (Currie et al., 2016) 1.70841317814921 2.7459035237934 1.57596980088809 0.283305474349728 0.45535208360406 0.261342442046213 0 0 SMESG000022963.1 SMESG000022963.1 SMEST022963001 barhl1 BarH-like 1 homeobox protein BARHL Helix-turn-helix 0 0 0 0.0558923657442283 0.102964867153848 0.141973962679596 0.185793117754629 0.342267918578489 0.471938963666882 MA0877.1 7.78043E-35 SMESG000074896.1 MSTRG.21923 SmMSTRG.21923 barhl2-1 BARHL1 BarH-like 2 homeobox protein 1 BARHL Helix-turn-helix 1 Reduction DV boundary, pharyngeal lesions DV-boundary epidermis (Önal et al., 2012; Wurtzel et al., 2017) 1.10348378971546 4.89923625841107 2.86788112053402 0.124397858581898 0.552300364457808 0.323301776960294 MA0635.1 3.00725E-46 SMESG000030375.1 MSTRG.9638 SmMSTRG.9638 barhl2-2 BARHL2-1 BarH-like 2 homeobox protein 2 BARHL Helix-turn-helix 1 0 0 (Önal et al., 2012; Cheng et al., 2018) 6.9311713776733 3.36249422950159 2.64959324316813 0.535504346920297 0.259787296876356 0.204708356203346 MA0635.1 9.79129E-46 - MSTRG.22261 SmMSTRG.22261 barx2 Homeobox protein BarH-like 2 BARX Helix-turn-helix 0 0 0 0.0178358437964906 0.220705121584012 0.434726271135376 0.0264914774240168 0.327812062749628 0.645696459826355 0 0 SMESG000033607.1 MSTRG.10410 SMEST033607001 bsx Brain specific homeobox BSX Helix-turn-helix 0 0 0 0.125260221234454 0.887828998349164 0.0713749197973044 0.115504253839099 0.818679904764754 0.0658158413961475 MA0876.1 1.59606E-31 SMESG000004481.1 MSTRG.2221 SMEST004481001 dbx Developing brain homeobox DBX Helix-turn-helix 0 0 0 0.0090526733097812 0.106498187056782 0.077543316835859 0.0468821662099692 0.551534948385001 0.40158288540503 MA0174.1 5.5868E-24 SMESG000045025.1 MSTRG.14008 SMEST045025001 dll-1 dlx Distal-less 1 DLX Helix-turn-helix 1 Eye defects Optic pigment cup (Lapan and Reddien, 2011; Currie et al., 2016) 0.643999092574766 4.2668515025338 1.55465008755082 0.0996054480826186 0.659941389222584 0.240453162694797 MA0879.1 1.64033E-37 SMESG000036140.1 MSTRG.11324 SMEST036140001 dll-2 Distal-less 2 DLX Helix-turn-helix 0 0 0 0.32230892667619 2.18868534858443 3.64509935605709 0.0523560793546929 0.355531523667866 0.592112396977441 0 0 SMESG000017219.1 MSTRG.5081 SMEST017219001 emx1 Homeobox protein EMX1 EMX Helix-turn-helix 0 0 0 1.36466050062417 1.03300860325163 0.267123762727523 0.512107532906914 0.387650618627013 0.100241848466073 MA0886.1 2.42348E-30 SMESG000025335.1 MSTRG.345 SmMSTRG.345 en EN2 Engrailed EMX Helix-turn-helix 0 0 0 (Currie et al., 2016) 0.598159795322097 1.06395748936256 3.10978264676874 0.125350448231196 0.222963076478116 0.651686475290688 0 0 SMESG000063219.1 MSTRG.18888 SmMSTRG.18888 lbx lbx1 Ladybird LBX Helix-turn-helix 1 No defects Body muscle layer (Scimone et al., 2017; Scimone et al., 2018) 1.41529130090523 1.19606486552166 2.64645770680481 0.269178661517609 0.227483302824963 0.503338035657427 MA0618.1 1.31972E-30 SMESG000019757.1 MSTRG.6954 SmMSTRG.6954 msx MSX-1 Msh homeobox MSX Helix-turn-helix 1 0 0 (Önal et al., 2012) 0.948955612254017 2.3502664582121 3.72057088547448 0.135182849153827 0.334805666344213 0.53001148450196 MA0666.1 1.07815E-40 SMESG000062714.1 MSTRG.18714 SMEST062714001 meox mox Mesenchyme homeobox MEOX Helix-turn-helix 1 0 0 (Roberts-Galbraith et al., 2016) 1.48415756870224 1.90896248635675 8.06359012744351 0.129544829629098 0.166623965863451 0.70383120450745 MA0661.1 5.95513E-27 SMESG000041571.1 MSTRG.8974 SMEST041571001 nkx1 NK1 homeobox NKX Helix-turn-helix 1 0 CNS (Lapan and Reddien, 2012) 0.187888294558687 4.56002882858883 1.85554384654207 0.0284530029663398 0.690551341110325 0.280995655923335 MA0245.1 1.26223E-33 SMESG000051002.1 MSTRG.13371 SMEST051002001 nkx1-1 NK1 homeobox 1 NKX Helix-turn-helix 1 Circular fiber loss Muscle (Currie et al., 2016b; Scimone et al., 2017; Scimone et al., 2018) 0.638916196831238 1.81573803219019 5.04095861574636 0.0852386869576948 0.242240103617096 0.672521209425209 MA0245.1 2.12124E-35 SMESG000077917.1 SMESG000077917.1 SMEST077917001 nkx1-2 NK1 homeobox 2 NKX Helix-turn-helix 0 0 0 0.0733312796283862 0.271875289416253 0.144828004766167 0.149645113931692 0.554808382808555 0.295546503259753 MA0245.1 3.27049E-31 SMESG000018735.1 MSTRG.6003 SmMSTRG.6003 nkx2l-1 nkx2l-1 NK2 homeobox-like 1 NKX Helix-turn-helix 1 Photoreceptor defects Ubiquitous (Cowles et al., 2014) 11.0711782074064 14.3551563540582 20.3321879844943 0.241947894980367 0.313715468842776 0.444336636176858 MA0672.1 3.70519E-28 SMESG000081885.1 MSTRG.22888 SmMSTRG.22888 nkx2l-2 nkx2-like NK2 homeobox-like 2 NKX Helix-turn-helix 1 0 Medial brain (Scimone et al., 2014; Fincher et al., 2018) 4.42335488551619 7.35056926945127 2.29233519156582 0.314465614243516 0.522567449409559 0.162966936346924 MA0253.1 5.26988E-29 - MSTRG.18812 SmMSTRG.18812 nkx2-1 NK2 homeobox 1 NKX Helix-turn-helix 0 0 0 0.0508757714064803 0 0.74774775112359 0.0637043237160156 0 0.936295676283984 0 0 SMESG000079512.1 MSTRG.23238 SmMSTRG.23238 nkx2-2 DTH-1, nkx2.2 NK2 homeobox 2 NKX Helix-turn-helix 1 Blastema defects, Neoblast proliferation defects Neoblasts (Forsthoefel et al., 2012; Önal et al., 2012; van Wolfswinkel et al., 2014; Fincher et al., 2018; Forsthoefel et al., 2020) 10.025304797035 4.99009844581133 13.3827741472283 0.35302634599849 0.17571896876577 0.47125468523574 MA0253.1 8.55227E-28 SMESG000062916.1 MSTRG.18813 SmMSTRG.18813 nkx2-3 NK2 homeobox 3 NKX Helix-turn-helix 0 0 0 0.125676454378252 1.12685066869366 1.75236500461013 0.0418239487602498 0.375005364855778 0.583170686383972 MA0253.1 3.94696E-23 SMESG000037282.1 MSTRG.12028 SMEST037282001 nkx2-4 nkx2.4 NK2 homeobox 4 NKX Helix-turn-helix 1 0 0 (van Wolfswinkel et al., 2014) 26.7004217860168 48.5666192446035 13.379762483667 0.301200051524853 0.547866559416053 0.150933389059094 MA0253.1 2.88125E-28 SMESG000021901.1 MSTRG.7792 SmMSTRG.7792 nkx3-1 NK3 homeobox 1 NKX Helix-turn-helix 0 0 0 0.798351013152869 0.828184557360089 0.277704270855179 0.419249191099415 0.434916095844872 0.145834713055713 MA0896.1 6.20198E-14 SMESG000027004.1 MSTRG.261 nkx3-2 NK3 homeobox 2 NKX Helix-turn-helix 0 0 0 0.406354114002084 0.400850599679894 0.623752545422387 0.28397362074701 0.280127583915948 0.435898795337041 MA0122.2 6.47503E-29 SMESG000033792.1 MSTRG.10592 SMEST033792001 nkx5-1 hmx-1 NK5 homeobox 1 NKX Helix-turn-helix 1 0 0 (Wenemoser et al., 2012; Currie et al., 2016) 0.405535729578225 1.06404612137663 0.161023105659748 0.248702622872055 0.652546845917701 0.0987505312102434 MA0897.1 6.44411E-32 SMESG000019482.1 MSTRG.6856 SMEST019482001 nkx5-2 NK5 homeobox 2 HMX Helix-turn-helix 0 0 0 0.385547922053773 0.810353459930285 0.283944724830945 0.260532443392758 0.54759306133147 0.191874495275772 MA0896.1 1.24203E-27 SMESG000039526.1 MSTRG.12684 SmMSTRG.12684 nkx5-3 NK5 homeobox 3 HMX Helix-turn-helix 0 0 0 0.156696311894346 0.314588471345092 0.317073126934303 0.198762909425001 0.399042702921268 0.402194387653731 MA0444.1 5.57696E-32 SMESG000002774.1 MSTRG.764 SmMSTRG.764 nkx6-1 nkx6-like NK6 homeobox 1 NKX Helix-turn-helix 1 0 Medial brain (Scimone et al., 2014; Fincher et al., 2018) 3.9085772853238 13.9103849907524 12.5811051066622 0.128571336244575 0.457577439405642 0.413851224349782 MA0674.1 1.64083E-36 SMESG000023118.1 MSTRG.7287 SMEST023118001 nkx6-2 NK6 homeobox 2 NKX Helix-turn-helix 1 No phenotype Muscle (Scimone et al., 2017; Scimone et al., 2018) 7.33731869442937 2.1110939708355 3.63429252639674 0.560841094172624 0.161365248234825 0.277793657592551 MA0191.1 6.16824E-38 SMESG000055068.1 MSTRG.16673 SMEST055068001 vax2 Ventral anterior homeobox 2 VAX Helix-turn-helix 0 0 0 0.0833544877842552 0.432118284424128 0.798255148462919 0.0634488210783112 0.328925249760483 0.607625929161206 0 0 SMESG000016670.1 MSTRG.5100 SmMSTRG.5100 alx3-1 alx-3 Homeobox protein aristaless-like 3 protein 1 ALX Helix-turn-helix 1 0 Neoblast (Molinaro et al., 2016) 2.88671919070917 8.78938509318193 1.94712006080621 0.211896913510992 0.645176565458463 0.142926521030544 0 0 SMESG000020038.1 MSTRG.6974 SmMSTRG.6974 alx3-2 Homeobox protein aristaless-like 3 protein 2 ALX Helix-turn-helix 0 0 0 0.602371518076135 3.20085612602546 5.44571469107413 0.0651286921516621 0.346078071419249 0.588793236429089 MA0853.1 5.48062E-33 SMESG000080420.1 MSTRG.23589 SMEST080420001 alx4 Homeobox protein aristaless-like 4 ALX Helix-turn-helix 0 0 0 0.0681766419291486 0.65674268052681 0.228641391950763 0.0714969072226996 0.6887266543226 0.2397764384547 MA0208.1 3.07287E-32 SMESG000017304.1 MSTRG.5091 SMEST017304001 arx Aristaless-related homeobox protein ARX Helix-turn-helix 0 0 0 0.874362380641881 0.594162867654327 0.258261081750343 0.506352387338108 0.34408592268524 0.149561689976652 MA0226.1 1.01671E-25 SMESG000067397.1 MSTRG.20047 SmMSTRG.20047 otp Homeobox protein orthopedia OTP Helix-turn-helix 0 0 0 0.231356001424247 4.09634312185823 0.527390783536389 0.0476522589415517 0.843721372925557 0.108626368132891 MA0236.1 5.41965E-35 SMESG000031965.1 MSTRG.10065 SmMSTRG.10065 otx-1 OTX2-1, otxA Orthodenticle homeobox 1 OTX Helix-turn-helix 1 Photoreceptor neuron defects Photoreceptors, CNS, Neoblasts (Lapan and Reddien, 2011; Lapan and Reddien, 2012; Wenemoser et al., 2012; Zhu et al., 2015; Roberts-Galbraith et al., 2016) 0.941286990154449 7.88201378619236 1.4268939569213 0.0918311324466257 0.768962345721144 0.13920652183223 MA0711.1 4.79879E-20 SMESG000023717.1 MSTRG.8421 SmMSTRG.8421 otx-2 otxB Orthodenticle homeobox 2 OTX Helix-turn-helix 1 0 CNS, Neoblasts (Scimone et al., 2014; Wurtzel et al., 2017) 0.203427715935702 4.49640679438224 1.32929378996747 0.0337408172133394 0.745780578955234 0.220478603831427 MA0711.1 3.48126E-19 SMESG000052478.1 MSTRG.15991 SMEST052478001 phox Paired-like homeobox PHOX Helix-turn-helix 0 0 0 0.0589711824401352 3.65882450141891 1.03099906092188 0.0124181367293135 0.770474340976744 0.217107522293942 MA0713.1 6.32207E-37 SMESG000080359.1 MSTRG.23506 SmMSTRG.23506 pitx Paired-like homeodomain transcription factor PITX Helix-turn-helix 1 Serotonergic neuron defects, blastemal defects Serotonergic neurons, blastemal pole (Currie and Pearson, 2013; März et al., 2013; Scimone et al., 2018) 2.18851904643105 4.20320396245676 4.60936123347899 0.198936668260637 0.382071791275772 0.41899154046359 MA0714.1 1.63475E-43 SMESG000033843.1 MSTRG.10612 SMEST033843001 rx Retinal homeobox protein Rx RAX Helix-turn-helix 0 0 0 0.110873930088146 0.733956132081283 0.335179040772544 0.0939602328589822 0.621991923834655 0.284047843306363 MA0202.1 9.60694E-40 SMESG000047763.1 MSTRG.14638 SMEST047763001 shox Short-stature homeobox SHOX Helix-turn-helix 0 0 0 1.86268117106638 0.780473474971972 1.1498093924355 0.491088539773199 0.205768751576671 0.30314270865013 MA0630.1 2.12146E-25 SMESG000005018.1 MSTRG.2333 SmMSTRG.2333 uncx Homeobox protein unc-4 homolog UNCX Helix-turn-helix 0 0 0 0.576554546008557 1.54016564458997 1.3234431249123 0.167595109048753 0.447701316285117 0.38470357466613 MA0721.1 4.27287E-41 SMESG000048803.1 MSTRG.15051 SMEST048803002 vsx Visual system homeobox VSX Helix-turn-helix 0 0 0 0.313344188352321 3.30054943577373 2.14092067288022 0.0544490529460398 0.573528399950407 0.372022547103553 MA0726.1 1.88687E-61 SMESG000022899.1 MSTRG.7450 SMEST022899001 irx-1 Iroquois homeobox 1 IRX Helix-turn-helix 0 0 0 2.58912580673129 4.2330549819963 6.22207137531535 0.198487868386072 0.324514960977595 0.476997170636333 MA0217.1 6.35944E-29 SMESG000015279.1 MSTRG.5557 SmMSTRG.5557 irx6-1 Iroquois homeobox 6 protein 1 IRX Helix-turn-helix 0 0 0 1.32709584149739 2.72804790182562 0.447243324318621 0.294753832036153 0.60591145559917 0.0993347123646765 MA0217.1 4.73654E-35 SMESG000026100.1 MSTRG.572 SmMSTRG.572 irx6-2 Iroquois homeobox 6 protein 2 IRX Helix-turn-helix 0 0 0 2.55005734960424 1.15315536581687 1.15605661988773 0.524782055416191 0.237310444481378 0.237907500102431 MA0217.1 3.74541E-36 SMESG000061184.1 MSTRG.18286 SmMSTRG.18286 irx6-3 Iroquois homeobox 6 protein 3 IRX Helix-turn-helix 0 0 0 6.88109050072477 8.41840841819843 9.50998479625552 0.277357263041908 0.339322192869655 0.383320544088437 MA0217.1 6.08505E-42 SMESG000013307.1 MSTRG.4755 SmMSTRG.4755 prep PBX/Knotted 1 Homeobox PNOX Helix-turn-helix 1 Anterior defects Anterior axially restricted (Felix and Aboobaker, 2010; Chen et al. 2013; Raz et al., 2021) 1.71701843271816 15.1426495805822 5.30542157041801 0.0774649895382969 0.683175654372514 0.239359356089189 MA0783.1 4.20675E-63 SMESG000001913.1 MSTRG.1510 pbx-1 Pbx Pre-B-cell leukemia transcription factor 1 PBX Helix-turn-helix 1 Anterior and posterior blastema defects Neoblasts (Blassberg et al., 2013; Chen et al., 2013) 91.4020866386063 119.161333616978 83.8404271546348 0.310464986930852 0.404754675134866 0.284780337934281 MA0222.1 1.11688E-130 SMESG000022232.1 MSTRG.7854 SmMSTRG.7854 pbx-2 Pre-B-cell leukemia transcription factor 2 PBX Helix-turn-helix 0 0 0 34.2235058839726 56.9639172400872 18.7784371432539 0.311219371182833 0.518014564716856 0.170766064100311 MA0222.1 4.1525E-64 SMESG000005966.1 MSTRG.1741 SmMSTRG.1741 pbx-3 Pre-B-cell leukemia transcription factor 3 PBX Helix-turn-helix 0 0 0 0.266068136043966 0.0396961400289299 0.0154499826971219 0.828319817005585 0.123581500338537 0.0480986826558773 0 0 SMESG000062973.1 MSTRG.18649 pbx-4 Pre-B-cell leukemia transcription factor 4 PBX Helix-turn-helix 0 0 0 0.159482618867653 0.35122913454559 0.173182880459167 0.233197646199702 0.513571999471364 0.253230354328934 MA0782.1 5.32196E-28 SMESG000014778.1 MSTRG.4467 SMEST014778001 pbx-5 Pre-B-cell leukemia transcription factor 5 PBX Helix-turn-helix 0 0 0 0.0715196584820935 0.828231060109551 0.330735572195243 0.0581230843590766 0.673092472716541 0.268784442924382 0 0 SMESG000006530.1 MSTRG.1897 SMEST006530001 meis-1 meis Meis Homeobox 1 MEIS Helix-turn-helix 1 Eye defects Pigment cup progenitors (Lapan and Reddien, 2012; Scimone et al., 2018) 3.48971618156964 5.48960584741802 4.10650932684802 0.266678981768582 0.419507610799975 0.313813407431443 MA0498.2 6.38888E-55 SMESG000078684.1 MSTRG.23026 meis-2 meis2 Meis homeobox 2 MEIS Helix-turn-helix 1 0 Neoblasts (van Wolfswinkel et al., 2014) 9.57854074246306 13.4906949208459 5.92024922226512 0.330414313337095 0.465365113388379 0.204220573274525 MA0227.1 4.63112E-49 SMESG000049852.1 MSTRG.15193 SmMSTRG.15193 meis-3 pbx4 Meis Homeobox 3 MEIS Helix-turn-helix 1 0 Ubiquitous (van Wolfswinkel et al., 2014) 3.97193738965872 9.87360536736888 4.88429265717928 0.212064724639595 0.527159216779855 0.26077605858055 0 0 SMESG000071247.1 MSTRG.20883 SmMSTRG.20883 meis-4 Meis Homeobox 4 MEIS Helix-turn-helix 0 0 0 9.80438205210639 9.97554453695086 5.29669536101804 0.390976985322258 0.397802565146575 0.211220449531167 0 0 SMESG000029617.1 MSTRG.9897 SMEST029617001 lim-1 LIM domain-binding protein 1 LIM Helix-turn-helix 0 0 0 0.120807335504839 0.79290025399423 15.4404474300484 0.0073869506165523 0.0484831073844236 0.944129941999024 0 0 SMESG000011768.1 MSTRG.3473 SMEST011768001 lim-2 LIM domain-binding protein 2 LIM Helix-turn-helix 0 0 0 117.136878740105 192.109743750882 117.729283850118 0.274340722744496 0.44993111062667 0.275728166628835 0 0 SMESG000036525.1 MSTRG.11416 SMEST036525001 lim-3 LIM domain-binding protein 3 LIM Helix-turn-helix 0 0 0 0.92066734917009 6.46647598301363 235.510555501807 0.0037903502321745 0.0266222200294831 0.969587429738342 0 0 SMESG000031934.1 MSTRG.10008 SMEST031934001 limd1 LIM domain containing 1 LIM Helix-turn-helix 0 0 0 5.33620430291397 6.19615283275495 37.2147211450985 0.109467161748221 0.127108188865538 0.76342464938624 0 0 SMESG000013182.1 MSTRG.4772 SmMSTRG.4772 lmpt-1 Limpet 1 LIM Helix-turn-helix 0 0 0 0.468784346470958 2.52513177806414 68.2967124534534 0.0065756798028247 0.035420248473497 0.958004071723678 0 0 SMESG000029176.1 MSTRG.9788 SmMSTRG.9788 lmpt-2 Limpet 2 LIM Helix-turn-helix 0 0 0 13.4626458452891 16.7763388123512 12.4207089411884 0.315582338023608 0.39325971185156 0.291157950124833 0 0 SMESG000009923.1 MSTRG.3802 SMEST009923001 lmpt-3 Limpet 3 LIM Helix-turn-helix 0 0 0 29.5630414307459 69.18193399534 82.3762375617572 0.163222413007637 0.381964833682863 0.4548127533095 MA0056.1 0.00165511 SMESG000072127.1 MSTRG.21174 SMEST072127001 lmpt-4 Limpet 4 LIM Helix-turn-helix 0 0 0 0.11285615781867 0.323479063329199 0.037398733671836 0.238226871159407 0.682828537068468 0.0789445917721251 0 0 SMESG000037769.1 MSTRG.11811 SMEST037769002 lmpt-5 Limpet 5 LIM Helix-turn-helix 0 0 0 0.23075985098378 3.15114089031338 39.7832687402508 0.0053459734724874 0.0730019348507462 0.921652091676766 0 0 SMESG000037556.1 MSTRG.11748 SMEST037556001 lmo1-1 lmo-1 LIM domain only 1 protein 1 LIM Helix-turn-helix 1 0 Neoblasts (Cheng et al., 2018) 142.79848899232 75.1806072243677 45.7394119495486 0.541480724979326 0.28507899482344 0.173440280197234 0 0 SMESG000028893.1 MSTRG.9218 SmMSTRG.9218 lmo1-2 LIM domain only 1 protein 2 LIM Helix-turn-helix 0 0 0 2.56076496718021 9.14558819754598 6.29090286336211 0.142286410949737 0.508165699441763 0.349547889608499 0 0 - MSTRG.20033 SmMSTRG.20033 lmo4 LIM domain only 4 LIM Helix-turn-helix 0 0 0 0.20058309390332 2.03470073784729 3.27975565650832 0.036370200853565 0.368936748717575 0.59469305042886 0 0 SMESG000081952.1 MSTRG.22894 SmMSTRG.22894 awh LIM/homeobox protein arrowhead LIM Helix-turn-helix 1 Brain defects CNS (Roberts-Galbraith et al., 2016; Scimone et al., 2020) 0.245113431758345 0.747475273872882 0.745071882398688 0.141059441324064 0.430161838866552 0.428778719809384 0 0 SMESG000059633.1 MSTRG.17848 SMEST059633001 isl-1 islet1 Insulin gene enhancer protein 1 ISL Helix-turn-helix 1 Anterior and posterior blastema defects Blastemal poles (März et al., 2013; Stückemann et al., 2017) 2.17290469900009 11.3746417292191 3.41284758068662 0.128116404480881 0.67065904973943 0.201224545779689 MA0914.1 4.29545E-46 SMESG000029651.1 MSTRG.9911 SmMSTRG.9911 isl-2 Insulin gene enhancer protein 2 ISL Helix-turn-helix 0 0 0 0.0534824785448027 0.514893462289023 0.330105790032473 0.0595253934581796 0.573070597431706 0.367404009110115 MA0914.1 1.94434E-23 SMESG000043039.1 MSTRG.13692 SmMSTRG.13692 lhx1-1 Lhx1/5-1 LIM homeobox 1 protein 1 LHX Helix-turn-helix 1 Serotonergic neuron defects CNS (Currie and Pearson, 2013; Scimone et al., 2018) 3.46869297295715 4.32277321911543 3.98525581410648 0.294538070197902 0.367060818523808 0.33840111127829 MA0704.1 1.25298E-36 SMESG000020988.1 MSTRG.6701 SMEST020988001 lhx1-2 lhx-1 LIM homeobox 1 protein 2 LHX Helix-turn-helix 1 0 CNS (van Wolfswinkel et al., 2014) 23.7113844123428 17.6760187009562 15.1708631272086 0.419238176635628 0.312527591029593 0.268234232334779 0 0 SMESG000022856.1 MSTRG.7427 SMEST022856001 lhx1-3 lhx1 LIM homeobox 1 protein 3 LHX Helix-turn-helix 1 0 0 (Roberts-Galbraith et al., 2016) 0.114322359013194 0.657370896069702 1.98877383655056 0.041414135803208 0.238137559423219 0.720448304773573 MA0194.1 5.31038E-37 SMESG000016568.1 MSTRG.5965 SMEST016568001 lhx1-4 LIM homeobox 1 protein 4 LHX Helix-turn-helix 0 0 0 0.295926885598717 1.1282111410216 3.21518912493055 0.0637865957566264 0.24318421705709 0.693029187186283 MA0704.1 1.21811E-36 SMESG000010916.1 MSTRG.4069 SmMSTRG.4069 lhx2-1 lhx2/9 LIM homeobox 2 protein 1 LHX Helix-turn-helix 1 0 Neoblasts (Scimone et al., 2014) 4.40126938424355 4.58863247709294 10.3498168315138 0.22757670130283 0.237264696036624 0.535158602660547 MA0700.1 1.09397E-73 SMESG000005304.1 MSTRG.2513 SmMSTRG.2513 lhx2-2 lhx-2 LIM homeobox 2 protein 2 LHX Helix-turn-helix 1 0 CNS (van Wolfswinkel et al., 2014) 11.251728806046 10.6020582774835 6.11908729765362 0.402237133471519 0.379012114844204 0.218750751684276 0 0 SMESG000001774.1 MSTRG.1469 SMEST001774001 lhx2-3 LIM homeobox 2 protein 3 LHX Helix-turn-helix 0 0 0 0.0831540338065434 0.586562345281065 0.746128541849047 0.0587310323164013 0.414284316458206 0.526984651225393 MA0701.1 1.89323E-60 SMESG000057112.1 MSTRG.17209 SMEST057112001 lhx2-4 LIM homeobox 2 protein 4 LHX Helix-turn-helix 0 0 0 1.35228038810541 3.44608301971819 3.23753903975595 0.168279841240821 0.428835845407278 0.402884313351901 MA0700.1 9.30426E-31 SMESG000071273.1 MSTRG.20979 SMEST071273001 lhx3 lhx3/4 LIM homeobox 3 LHX Helix-turn-helix 1 0 Neoblasts (Scimone et al., 2014) 0.106205336236044 2.12830350725013 3.05278306438277 0.020086906130146 0.402531871577325 0.577381222292529 MA0195.1 4.89902E-87 SMESG000039808.1 MSTRG.12466 SMEST039808001 lmx1-1 LIM homeobox transcription factor 1 protein 1 LMX Helix-turn-helix 0 0 0 0.206557329510873 1.95048125870394 3.86390462777255 0.0343064736040697 0.323949452558337 0.641744073837594 MA0703.1 5.56843E-34 SMESG000053732.1 MSTRG.16327 SmMSTRG.16327 lmx1-2 LIM homeobox transcription factor 1 protein 2 LMX Helix-turn-helix 0 0 0 0.205947991636278 3.42465900263101 3.75563329231841 0.0278826552678369 0.463653884757933 0.50846345997423 MA0702.1 3.13918E-44 SMESG000001688.1 MSTRG.1403 SMEST001688001 six1/2-1 six1/2 Sine oculis-related homeobox 1/2 protein 1 SIX Helix-turn-helix 1 Eye defects Optic pigment cup (Lapan and Reddien, 2011) 0.015610931215132 0.0424419080587479 0 0.268909004458564 0.731090995541436 0 0 0 SMESG000001687.1 MSTRG.1402 SmMSTRG.1402 six1/2-2 six-1/2 Sine oculis-related homeobox 1/2 protein 2 SIX Helix-turn-helix 0 0 0 (Fincher et al., 2018) 3.0238375834295 5.32379089306449 0.699016129738096 0.334249626800463 0.58848237382919 0.0772679993703472 MA0246.1 1.0996E-102 SMESG000005975.1 MSTRG.1743 SMEST005975001 six1/2-3 six1/2-2 Sine oculis-related homeobox 1/2 protein 3 SIX Helix-turn-helix 1 Lysis, protonephridia loss Protonephridia (Scimone et al., 2011; Raz et al., 2021) 78.7001618472047 106.876265750731 49.4405244981145 0.334870149345825 0.454759815398555 0.210370035255621 MA0246.1 3.868E-110 SMESG000009894.1 MSTRG.3785 SMEST009894001 six3 six3-1 Sine oculis-related homeobox 3 SIX Helix-turn-helix 1 0 0 (Wenemoser et al., 2012; Cheng et al., 2018) 4.27615154751523 1.12204534131938 0.87746539937046 0.681386497733018 0.178793136053263 0.139820366213719 MA0631.1 3.42805E-83 SMESG000029688.1 MSTRG.9925 SmMSTRG.9925 six4 Sine oculis-related homeobox 4 SIX Helix-turn-helix 0 0 0 1.22412321536395 3.68413602745811 1.41461791337084 0.193602245484872 0.582667658480397 0.223730096034731 MA0204.1 5.73391E-74 SMESG000060967.1 MSTRG.18230 SmMSTRG.18230 six6-1 six6 Sine oculis-related homeobox 6 protein 1 SIX Helix-turn-helix 1 0 DV boundary (van Wolfswinkel et al., 2014; Cheng et al., 2018) 10.6951452075917 12.0521356081505 7.9498566802914 0.348408551415377 0.392614314924567 0.258977133660056 0 0 SMESG000017729.1 MSTRG.6271 SmMSTRG.6271 six6-2 Sine oculis-related homeobox 6 protein 2 SIX Helix-turn-helix 0 0 0 2.60181684290101 6.6485364694884 4.55533705514459 0.188459741862641 0.481579427938161 0.329960830199198 MA0631.1 4.12068E-107 SMESG000020326.1 MSTRG.7110 SMEST020326001 six6-3 Sine oculis-related homeobox 6 protein 3 SIX Helix-turn-helix 0 0 0 0.0186959134299205 0.428362171752572 0.695518986659229 0.0163629341868243 0.374908776229944 0.608728289583232 MA0631.1 8.36981E-84 SMESG000068287.1 MSTRG.20222 SMEST068287001 prox-1 Prospero homeobox protein 1 PROX Helix-turn-helix 1 0 Neoblasts (Wagner et al., 2012; van Wolfswinkel et al., 2014; Fincher et al., 2018) 19.3404087783971 8.1725143948743 2.0517469606354 0.654172994009366 0.276428397741584 0.0693986082490504 0 0 SMESG000035419.1 MSTRG.11112 SMEST035419001 prox-2 Prospero homeobox protein 2 PROX Helix-turn-helix 1 0 Neoblasts (Scimone et al., 2014) 0.0640808814418178 0.304637565251601 0.0369737094252303 0.157954450130105 0.750908196417055 0.0911373534528407 0 0 SMESG000032751.1 MSTRG.10720 SmMSTRG.10720 prox-3 Prospero homeobox protein 3 PROX Helix-turn-helix 0 0 0 0.062141207317123 3.53947875752648 0.635444093516628 0.0146661005028968 0.835361162534861 0.149972736962242 0 0 SMESG000012837.1 MSTRG.4605 SMEST012837001 prox-4 Prospero homeobox protein 4 PROX Helix-turn-helix 0 0 0 0.190239832631378 0.40373166731219 0.823404611254398 0.134219725539601 0.284844413647522 0.580935860812877 0 0 SMESG000013012.1 MSTRG.4666 SmMSTRG.4666 zeb-1 Zinc finger E-Box binding homeobox 1 ZEB Helix-turn-helix 1 Defective cell migration Migrating neoblasts (Abnave et al., 2017) 0.475186161267249 6.48160469405975 2.71865525226377 0.0491125841623412 0.669902412972429 0.28098500286523 MA0103.2 2.04058E-39 SMESG000064905.1 MSTRG.17691 SMEST064905001 zfhx3 hox3 Zinc finger homeobox protein 3 ZFHX Helix-turn-helix 1 0 Ubiquitous (van Wolfswinkel et al., 2014; Zhu et al., 2015) 11.3348919925923 20.4770929747477 6.83620090592785 0.29328393394093 0.529833225339337 0.176882840719733 MA0038.1 1.68234E-06 SMESG000007728.1 MSTRG.3166 SMEST007728001 onecut-1 One cut homeobox 1 Onecut Helix-turn-helix 0 0 0 3.39384819768434 7.508033434387 8.44705932365203 0.175402271651485 0.388033301231722 0.436564427116793 MA0679.1 1.86004E-77 SMESG000022199.1 MSTRG.7853 SMEST022199001 onecut-2 One cut homeobox 2 Onecut Helix-turn-helix 0 0 0 0.290032386037154 0.854135663766336 0.0214709948786432 0.248818351924927 0.732761713553664 0.0184199345214094 MA0679.1 1.75042E-47 SMESG000011334.1 MSTRG.4161 SMEST011334006 onecut-3 One cut homeobox 3 Onecut Helix-turn-helix 0 0 0 0.399970218098454 0.289713015049721 0 0.579933219882297 0.420066780117703 0 MA0679.1 2.83535E-79 - MSTRG.3339 SmMSTRG.3339 onecut-4 One cut homeobox 4 Onecut Helix-turn-helix 0 0 0 0.039771899384589 0.64958000325112 0.207044428243978 0.0443686548176279 0.724657142018474 0.230974203163898 MA0235.1 5.76075E-27 - MSTRG.1496 SmMSTRG.1496 onecut-5 One cut homeobox 5 Onecut Helix-turn-helix 0 0 0 0.943843523558406 2.39542385906242 1.02885658189457 0.216075260506742 0.548387334819645 0.235537404673613 MA0679.1 1.21081E-73 SMESG000055165.1 MSTRG.16685 SMEST055165001 hnf6 Hepatocyte nuclear factor 6 Onecut Helix-turn-helix 1 0 Ubiquitous (van Wolfswinkel et al., 2014) 11.8965935637229 27.282770358166 17.1863568519417 0.211060790146876 0.484031251328074 0.30490795852505 MA0679.1 2.17688E-71 SMESG000065026.1 MSTRG.17728 SmMSTRG.17728 cux-1 Cut-like1 Homeobox protein cut-like 1 CUX Helix-turn-helix 1 0 Neoblasts (Molinaro et al., 2016; Mihaylova et al., 2018) 4.74498077975826 7.05940366220887 2.08616145839225 0.341597861869165 0.508216431006231 0.150185707124605 0 0 SMESG000001909.1 MSTRG.1504 SMEST001909001 cux-2 Homeobox protein cut-like 2 CUX Helix-turn-helix 0 0 0 0.694090430507003 1.94119515681207 0 0.263383381993567 0.736616618006433 0 MA0679.1 1.88836E-47 SMESG000057970.1 MSTRG.15832 SMEST057970001 pou1 POU class 1 POU Helix-turn-helix 1 0 0 (Önal et al., 2012) 0.241921645236964 2.26496342982145 1.03847126900289 0.0682362001896364 0.638853534036262 0.292910265774101 MA0789.1 3.63593E-83 SMESG000076173.1 MSTRG.22352 SMEST076173001 pou2/3-1 POU50, pou2/3 POU class 2/3 homeobox 1 POU Helix-turn-helix 1 Lysis, protonephridia loss Protonephridia (Reddien et al., 2005; Scimone et al., 2011; Önal et al., 2012; Fincher et al., 2018; Raz et al., 2021) 5.64004202580807 19.7462467558454 1.53640857877827 0.209490228646155 0.733442362460547 0.0570674088932978 MA0254.1 2.59535E-80 SMESG000008858.1 MSTRG.2646 SMEST008858001 pou2/3-2 POU2/3-2 POU class 2/3 homeobox 2 POU Helix-turn-helix 1 0 CNS (Roberts-Galbraith et al., 2016) 0.044206905130245 0.569656989006159 0.64002942910519 0.0352557145897869 0.454310568887526 0.510433716522687 MA0254.1 5.16978E-65 SMESG000026461.1 MSTRG.85 SmMSTRG.85 pou2/3-3 pou2-2, pou2f3 POU class 2/3 homeobox 3 POU Helix-turn-helix 1 0 Ubiquitous (van Wolfswinkel et al., 2014) 4.85779565058643 7.0722084875187 4.68827738068763 0.292316365268755 0.425567979428023 0.282115655303221 0 0 SMESG000013430.1 MSTRG.4837 SmMSTRG.4837 pou4-1 pou4l-1/pou4 POU class 4 homeobox 1 POU Helix-turn-helix 1 Brain defects CNS (Önal et al., 2012; van Wolfswinkel et al., 2014; Cowles et al., 2014) 5.45249417676764 5.75661103642606 2.501232974517 0.397692172294845 0.419873744732717 0.182434082972438 MA0791.1 1.0901E-75 SMESG000030759.1 MSTRG.9708 SMEST030759001 pou4-2 POU class 4 homeobox 2 POU Helix-turn-helix 1 0 0 (Önal et al., 2012) 0.0598776633465027 2.19207248131302 2.06682233981736 0.0138645097795086 0.507568409586766 0.478567080633725 MA0791.1 4.65931E-79 SMESG000048750.1 MSTRG.15043 SMEST048750001 pou5 POU class 5 POU Helix-turn-helix 0 0 0 0.743750757239245 0.168466394821102 0.0689450842543362 0.758030353912547 0.17170085495124 0.0702687911362131 0 0 SMESG000062200.1 MSTRG.18538 SmMSTRG.18538 pou6-1 POU6F1 POU class 6 homeobox 1 POU Helix-turn-helix 1 0 Ubiquitous (van Wolfswinkel et al., 2014) 12.3697181609423 14.3499297037775 7.89856820282028 0.357318185801632 0.414519618104549 0.228162196093819 0 0 SMESG000058834.1 MSTRG.15683 SmMSTRG.15683 pou6-2 POU6 POU class 6 homeobox 2 POU Helix-turn-helix 1 0 CNS (Önal et al., 2012; van Wolfswinkel et al., 2014) 5.85660579238115 8.50199786707948 2.75656182721351 0.342188090260716 0.496752302728194 0.16105960701109 MA0628.1 8.42905E-71 SMESG000032046.1 MSTRG.10087 SMEST032046001 pou-p1 pou2-1 POU class P homeobox 1 POU Helix-turn-helix 1 0 CNS (Önal et al., 2012; van Wolfswinkel et al., 2014) 26.6322822283538 13.7297249732697 11.3410047554505 0.515101175352512 0.265549809451501 0.219349015195987 MA0481.1 0.0224501 SMESG000058788.1 MSTRG.15676 SmMSTRG.15676 phtf Protein PHTF PHTF Helix-turn-helix 0 0 0 6.84241061811284 14.1295108974765 10.4068108300525 0.218058860464553 0.450289410733284 0.331651728802163 0 0 SMESG000004009.1 MSTRG.2111 SmMSTRG.2111 pax2/5/8-1 pax-2/5/8 Paired box 2/5/8 protein 1 PAX Helix-turn-helix 1 Loss of epidermal precursors Epidermis (Cheng et al., 2018) 2.45307293660957 32.060530785216 6.85461177821395 0.0592984954017954 0.775003958901379 0.165697545696826 MA0014.2 3.10618E-71 SMESG000066574.1 MSTRG.19704 SmMSTRG.19704 pax2/5/8-2 Paired box 2/5/8 protein 2 PAX Helix-turn-helix 0 0 0 8.00465608728968 9.02182752159762 6.89244127968046 0.334657854589257 0.377183655353576 0.288158490057166 0 0 SMESG000080212.1 MSTRG.23527 SmMSTRG.23527 pax2/5/8-3 Paired box 2/5/8 protein 3 PAX Helix-turn-helix 0 0 0 1.85302530404841 1.32985101788729 2.42858253481001 0.330221668082059 0.236988464468314 0.432789867449627 0 0 - MSTRG.11299 SmMSTRG.11299 pax2/5/8-4 Paired box 2/5/8 protein 4 PAX Helix-turn-helix 0 0 0 0.666675464221234 0.735440569355652 1.30575954258697 0.246198706502493 0.271593191293346 0.482208102204161 0 0 - MSTRG.11300 SmMSTRG.11300 pax2/5/8-5 Paired box 2/5/8 protein 5 PAX Helix-turn-helix 0 0 0 8.87909510952319 4.1428250354946 4.90290093239775 0.495351951976271 0.231122253193052 0.273525794830676 0 0 SMESG000030143.1 MSTRG.9597 SMEST030143001 pax3/7-1 Pax3/7-like Paired box 3/7 protein 1 PAX Helix-turn-helix 1 Loss of neurons CNS (Scimone et al., 2014) 0.502340245954262 2.18417415356299 0.410611309551333 0.162195626894761 0.705226186708401 0.132578186396837 MA0854.1 6.19168E-25 SMESG000042806.1 MSTRG.8926 SMEST042806001 pax3/7-2 Paired box 3/7 protein 2 PAX Helix-turn-helix 0 0 0 1.8195855673814 0.278144628681202 0.0483017168618404 0.847883741347449 0.129608803581196 0.0225074550713547 0 0 SMESG000039056.1 MSTRG.12215 SmMSTRG.12215 pax6-1 Pax6a Paired box 6 protein 1 PAX Helix-turn-helix 1 0 Neoblasts, CNS (Wenemoser et al., 2012; Scimone et al., 2014; Fincher et al., 2018) 3.994218882455 9.84319722939058 1.81949225228815 0.255109041297374 0.628680771482256 0.11621018722037 MA0069.1 3.78629E-82 SMESG000077501.1 MSTRG.21546 SmMSTRG.21546 pax6-2 Pax6b Paired box 6 protein 2 PAX Helix-turn-helix 1 0 Neoblasts, CNS (Wenemoser et al., 2012; Scimone et al., 2014) 0.914027504673638 1.13601083846671 0.619215434136911 0.342428101986609 0.425591170138002 0.231980727875389 MA0069.1 3.66606E-56 SMESG000065670.1 MSTRG.19539 SMEST065670001 foxA1 foxA Forkhead box A1 FOX Helix-turn-helix 1 Pharynx defects Pharynx (Adler et al., 2014; Roberts-Galbraith et al., 2016; Fincher et al., 2018; Mihaylova et al., 2018; Pascual-Carreras et al., 2021) 3.12672174322867 2.24720393617701 0.897998359543733 0.498526723826906 0.358295783275052 0.143177492898041 MA0446.1 2.90768E-65 SMESG000067799.1 MSTRG.20157 SMEST067799001 foxA2 Forkhead box A2 FOX Helix-turn-helix 1 Mild regeneration defects Ventral discrete cells in D/V margin (Pascual-Carreras et al., 2021) 0.257800036580291 0.548822764015714 2.89958584330763 0.0695589647939404 0.148081993418928 0.782359041787131 MA0446.1 1.3737E-57 SMESG000028135.1 MSTRG.9479 SMEST028135001 foxA(P) Forkhead box A(P) FOX Helix-turn-helix 1 Anterior defects 0 (Pascual-Carreras et al., 2021) 0.167731216598359 0.0566081604846264 2.22859819208588 0.0683797332254124 0.0230777012819804 0.908542565492607 MA0148.3 5.74136E-33 SMESG000015673.1 MSTRG.5625 SMEST015673001 foxC1 Forkhead box C1 FOX Helix-turn-helix 1 Mild regeneration defects Pharynx (Pascual-Carreras et al., 2021) 2.89219913375231 2.82838741872143 1.24361465307976 0.41529517146144 0.406132352475108 0.178572476063451 MA0846.1 3.0051E-57 SMESG000004239.1 MSTRG.2171 SMEST004239001 foxC2 Forkhead box C2 FOX Helix-turn-helix 1 Anterior defects Discrete cells around pharynx (Pascual-Carreras et al., 2021) 1.52692326024623 1.00153162769011 1.53303332548816 0.375951665992594 0.246592277278987 0.377456056728419 MA0846.1 1.57796E-49 SMESG000077075.1 MSTRG.22528 SMEST077075001 foxD1 foxD Forkhead box D1 FOX Helix-turn-helix 1 Loss of anterior identity Anterior pole (Scimone et al., 2014; Vásquez-Doorman et al., 2014; Vogg et al., 2014; Fincher et al., 2018; Pascual-Carreras et al., 2021; Raz et al., 2021) 1.36640808411756 1.82035810201734 0.821038906148372 0.340936760310146 0.454203250932113 0.204859988757742 MA0847.1 5.82887E-50 SMESG000065690.1 MSTRG.19546 SMEST065690001 foxD2 Forkhead box D2 FOX Helix-turn-helix 1 Anterior defects 0 (Pascual-Carreras et al., 2021) 0.748300715062068 0.691354972487573 8.33862544058885 0.0765268154245145 0.0707031188230101 0.852770065752475 MA0847.1 5.63903E-46 SMESG000021762.1 MSTRG.7741 SMEST021762001 foxD3 Forkhead box D3 FOX Helix-turn-helix 1 Anterior defects 0 (Pascual-Carreras et al., 2021) 0.980314206496422 0.839881346815608 1.97707245401667 0.25816302789385 0.221180423713745 0.520656548392406 MA0847.1 1.93326E-44 SMESG000075929.1 MSTRG.22295 SmMSTRG.22295 foxF1 FoxF-like Forkhead box F1 FOX Helix-turn-helix 1 Mild regeneration defects Anterior D/V margin (Scimone et al., 2014; Pascual-Carreras et al., 2021) 6.12202694449218 6.16683386563508 2.00825567651884 0.428200116450777 0.431334099529445 0.140465784019778 MA0030.1 9.09548E-39 SMESG000066497.1 MSTRG.19765 SmMSTRG.19765 foxF2 foxF-1, FOXF1 Forkhead box F2 FOX Helix-turn-helix 1 Defects in muscular system Ubiquitous (Wang et al., 2016; He et al., 2017; Fincher et al., 2018; Scimone et al., 2018; Pascual-Carreras et al., 2021) 2.53252080611728 22.8317211679403 15.9647649385996 0.0612770786259005 0.552438175352044 0.386284746022056 MA0030.1 3.9931E-46 SMESG000010270.1 MSTRG.3929 SMEST010270001 foxG Forkhead box G FOX Helix-turn-helix 1 Posterior defects D/V margin (Pascual-Carreras et al., 2020; Pascual-Carreras et al., 2021) 3.41694993006866 3.58300780833475 2.04823862222319 0.377638790525986 0.395991384971073 0.22636982450294 MA0613.1 2.264E-52 SMESG000021434.1 MSTRG.6819 SMEST021434001 foxL1 Forkhead box L1 FOX Helix-turn-helix 1 Mild regeneration defects 0 (Pascual-Carreras et al., 2021) 0.33426445566992 1.03433140757742 3.78823174165191 0.0648197848135065 0.200575137822089 0.734605077364404 MA0033.2 3.1027E-48 SMESG000062929.1 MSTRG.18815 SmMSTRG.18815 foxQ/D foxQ2 Forkhead box Q/D FOX Helix-turn-helix 1 Eye defects Eyes (Lapan et al., 2012; Scimone et al., 2014; Pascual-Carreras et al., 2021) 0.0967775205607087 0.683668625962639 0.307794112408681 0.0889302888460345 0.628233168504144 0.282836542649821 MA0851.1 1.85976E-24 SMESG000072183.1 MSTRG.21195 SMEST072183001 foxJ1-1 Forkhead box J1-1 FOX Helix-turn-helix 1 0 1 (Vij et al., 2012; Pascual-Carreras et al., 2021) 0.0532231254484922 0.588853815027435 0.434571647744551 0.0494340735043931 0.54693223162138 0.403633694874226 MA0851.1 1.65631E-25 SMESG000072873.1 SMESG000072873.1 SMEST072873001 foxJ1-2 Forkhead box J1-2 FOX Helix-turn-helix 1 0 1 (Vij et al., 2012; Pascual-Carreras et al., 2021) 0.0118276461194962 0.0120333375221171 0 0.495689796244146 0.504310203755854 0 MA0851.1 2.85923E-21 SMESG000067319.1 MSTRG.19883 SMEST067319002 foxJ1-3 Forkhead box J1-3 FOX Helix-turn-helix 1 0 0 (Vij et al. 2012; Pascual-Carreras et al. 2021) 6.56153225194938 1.47297768839894 1.98378443714535 0.6549550257467 0.147028788823376 0.198016185429924 MA0851.1 1.55679E-25 SMESG000010030.1 MSTRG.3843 SMEST010030001 foxJ1-4 Forkhead box J1-4 FOX Helix-turn-helix 1 Edemas and cilia defetcs Ventral widely (Vij et al., 2012; Wurtzel et al., 2017; Pascual-Carreras et al., 2021) 0.544374318515105 2.11649981303078 3.19795394414146 0.0929152232293895 0.361249687768398 0.545835089002212 MA0851.1 3.23712E-30 SMESG000017088.1 MSTRG.5337 SMEST017088001 foxJ1-5 Forkhead box J1-5 FOX Helix-turn-helix 1 Mild regeneration defects Dorsal widely (Pascual-Carreras et al., 2021) 0.877336052422166 1.8178424252885 0.944078606170585 0.241075591034225 0.49950920844256 0.259415200523215 MA0851.1 6.43264E-18 SMESG000061695.1 MSTRG.18451 SmMSTRG.18451 foxK1 foxK-2 Forkhead box K1 FOX Helix-turn-helix 1 Anterior defects CNS (van Wolfswinkel et al., 2014; Pascual-Carreras et al., 2021) 18.7651868801232 38.044467809959 20.1307842421582 0.243892381438702 0.494466477419811 0.261641141141486 MA0852.1 1.32485E-48 SMESG000040645.1 MSTRG.12975 SMEST040645001 foxK2 foxK-1 Forkhead box K2 FOX Helix-turn-helix 1 Anterior defects CNS (van Wolfswinkel et al., 2014; Pascual-Carreras et al., 2021) 3.33923244582681 11.380298321787 7.49477578561166 0.150319004458951 0.512295906897648 0.337385088643401 MA0852.1 4.35071E-51 SMESG000064173.1 MSTRG.17474 SmMSTRG.17474 foxK3 Forkhead box K3 FOX Helix-turn-helix 1 Anterior defects CNS (Pascual-Carreras et al., 2021) 3.69657376387684 9.13893238835358 17.2011724313826 0.123068659325521 0.304259086533605 0.572672254140874 MA0852.1 3.50348E-47 SMESG000048193.1 MSTRG.14880 SmMSTRG.14880 foxN2/3-1 foxN Forkhead box N2/3-1 FOX Helix-turn-helix 1 Anterior defects CNS (van Wolfswinkel et al., 2014; Pascual-Carreras et al., 2021) 8.07181926234694 15.7562086075312 4.58267576881863 0.284111909546398 0.554587060141322 0.16130103031228 MA0851.1 8.45477E-24 SMESG000015734.1 MSTRG.5693 SMEST015734001 foxN2/3-2 Forkhead box N2/3-2 FOX Helix-turn-helix 1 Anterior defects CNS (Pascual-Carreras et al., 2021) 6.51005950993551 12.5819061143805 4.3214313765081 0.278048482657444 0.537380633572209 0.184570883770347 MA0851.1 4.24716E-22 SMESG000033244.1 MSTRG.10837 SmMSTRG.10837 foxN2/3-3 foxJ Forkhead box N2/3-13 FOX Helix-turn-helix 1 0 0 (van Wolfswinkel et al., 2014; Pascual-Carreras et al., 2021) 20.0690115519441 42.4013144460544 12.0986807618567 0.269133416468521 0.568618468831228 0.16224811470025 MA0851.1 6.48629E-19 SMESG000044628.1 MSTRG.13758 SmMSTRG.13758 foxN(P) foxJ2 Forkhead box N(P) FOX Helix-turn-helix 1 Anterior defects CNS (Wurtzel et al., 2017; Pascual-Carreras et al., 2021) 4.02264003477075 7.03035146291327 6.16227949911514 0.233666959731199 0.408378785568953 0.357954254699847 MA0614.1 1.99337E-28 SMESG000037781.1 MSTRG.11814 SMEST037781001 foxO Forkhead box O FOX Helix-turn-helix 1 Defects in cell death Ubiquitous (van Wolfswinkel et al., 2014; Pascual-Carreras et al., 2021) 37.6020511049209 36.9984278278433 34.4351162954268 0.344860327732672 0.339324307354975 0.315815364912354 MA0848.1 1.71178E-26 SMESG000068148.1 MSTRG.20250 SMEST068148001 foxP albino Forkhead box P FOX Helix-turn-helix 1 Defects in pigment cells Ubiquitous (van Wolfswinkel et al., 2014; Wang et al., 2016; He et al., 2017; Pascual-Carreras et al., 2021) 15.4949897122737 26.0504269871937 18.6462613624259 0.257427441985264 0.432791173564007 0.309781384450729 MA0481.1 5.94565E-25 SMESG000039870.1 MSTRG.12479 SMEST039870002 e2f5 Transcription factor E2F5 E2F Helix-turn-helix 0 0 0 90.7625394940836 61.295540537145 56.6976628529054 0.434778647236832 0.29362325409733 0.271598098665838 0 0 SMESG000048838.1 MSTRG.15064 SmMSTRG.15064 dp-2 Transcription factor Dp-2 DP Helix-turn-helix 0 0 0 79.6174939485469 91.0058330458486 29.2877502271306 0.398264543691698 0.455231567508402 0.146503888799899 0 0 SMESG000017202.1 MSTRG.5418 SMEST017202001 rfx3 Transcription factor RFX3 RFX Helix-turn-helix 1 0 Ubiquitous (van Wolfswinkel et al., 2014) 22.5345683318637 27.5231928516638 11.1382375312185 0.368235976291595 0.449754778575609 0.182009245132796 MA0798.1 7.39495E-115 SMESG000058756.1 MSTRG.15672 SmMSTRG.15672 rfx4 Transcription factor RFX4 RFX Helix-turn-helix 0 0 0 0.138657619393918 0.38520030391704 1.08121379281922 0.0863871800870189 0.239989465919789 0.673623353993192 MA0799.1 8.33743E-46 SMESG000021065.1 MSTRG.6725 SmMSTRG.6725 rfx7 Transcription factor RFX7 RFX Helix-turn-helix 1 0 Ubiquitous (van Wolfswinkel et al., 2014) 24.8614012697634 6.28322285824432 2.77535794337528 0.732942641816371 0.185236620851437 0.0818207373321915 MA0510.2 9.23383E-29 SMESG000056045.1 MSTRG.16929 SMEST056045001 hsf-1 Heat shock transcription factor 1 HSF Helix-turn-helix 0 0 0 23.673040935011 28.7610159392437 22.2946547908582 0.316786418600372 0.38487236429463 0.298341217104998 0 0 SMESG000057343.1 MSTRG.17153 SMEST057343001 hsf-2 Heat shock transcription factor 2 HSF Helix-turn-helix 0 0 0 11.9814416421752 12.881413050949 7.94241900245148 0.365229132162098 0.392662873978286 0.242107993859617 0 0 SMESG000028667.1 MSTRG.9154 SMEST028667001 hsf-3 Heat shock transcription factor 3 HSF Helix-turn-helix 0 0 0 20.8656752574022 16.7277318854405 11.5519738460987 0.424570424270337 0.340372412398319 0.235057163331343 0 0 SMESG000016880.1 MSTRG.5224 SMEST016880001 myb-1 Transcriptional activator Myb 1 MYB Helix-turn-helix 1 Defective epidermal differentiation Neoblasts (Zhu et al., 2015; Zhu and Pearson, 2018) 47.8135690801463 150.801713351167 24.9853567525443 0.213834670842919 0.674424339311342 0.11174098984574 0 0 SMESG000041758.1 MSTRG.9023 SmMSTRG.9023 myb-2 Transcriptional activator Myb 2 MYB Helix-turn-helix 0 0 0 11.310799210744 10.0363764614928 4.6975858875846 0.434283077799141 0.385351059499645 0.180365862701214 0 0 SMESG000016533.1 MSTRG.5955 SMEST016533001 ehf Ets homologous factor EHF Helix-turn-helix 0 0 0 4.80093147301566 7.5318730122714 9.67755390590172 0.218121458437386 0.342196745659833 0.439681795902781 0 0 SMESG000065612.1 MSTRG.19528 SmMSTRG.19528 ets-1 ETS1 ETS proto-oncogene 1 ETS Helix-turn-helix 1 Pigmentation defects Pigment cells (He at al., 2017; Fincher et al., 2018) 5.37987666220983 26.3959629972236 22.2486225996626 0.0995822343665073 0.488592794697912 0.411824970935581 MA0098.3 6.03806E-41 SMESG000031150.1 MSTRG.10251 SmMSTRG.10251 ets-2 ETS proto-oncogene 2 ETS Helix-turn-helix 0 0 0 0.871970401088692 0.799000715519367 0.933667664111413 0.334775941886203 0.306760661568074 0.358463396545723 0 0 SMESG000033821.1 MSTRG.10604 SmMSTRG.10604 ets-3 ETS proto-oncogene 3 ETS Helix-turn-helix 0 0 0 0.259514299126922 1.42050528831571 5.58385221909212 0.0357267179320891 0.195557593271097 0.768715688796813 MA0641.1 2.4029E-19 MSTRG.6709 SmMSTRG.6709 ets-4 ETS proto-oncogene 4 ETS Helix-turn-helix 1 No defects 0 (Mihaylova et al., 2018) 4.04662703969684 2.78223631342812 0.986257972039729 0.517794525680197 0.356006797293001 0.126198677026802 0 0 SMESG000036336.1 MSTRG.11379 SmMSTRG.11379 ets-5 ETS proto-oncogene 5 ETS Helix-turn-helix 0 0 0 1.5426681299398 4.23053062689143 1.79015213229793 0.203966225097011 0.559346074102154 0.236687700800835 MA0474.2 3.998E-57 SMESG000009191.1 MSTRG.2731 SMEST009191001 elf1 ETS-related transcription factor 1 ELF Helix-turn-helix 0 0 0 21.4646989465323 79.9902789285473 81.9370541760039 0.117042701945488 0.436170961376698 0.446786336677814 MA0026.1 1.75985E-31 SMESG000069596.1 MSTRG.19189 SmMSTRG.19189 elf3 ETS-related transcription factor 3 ELF Helix-turn-helix 0 0 0 5.55396167439189 3.02744709051892 6.15066460514921 0.376997964568871 0.205500408155148 0.417501627275981 0 0 MSTRG.5700 SmMSTRG.5700 elf5 ETS-related transcription factor 5 ELF Helix-turn-helix 1 No defects 0 (Mihaylova et al., 2018) 0.972344433247141 1.07154602739704 0.52100172654667 0.379097584726196 0.417774295835268 0.203128119438536 0 0 SMESG000008885.1 MSTRG.2656 SMEST008885001 etv4 ETS translocation variant 4 ETV Helix-turn-helix 0 0 0 0.0910686714871531 0.948362815347206 3.44415770803882 0.0203115556597573 0.211518668220457 0.768169776119786 MA0764.1 2.76072E-34 SMESG000008317.1 MSTRG.3296 SmMSTRG.3296 etv7 ETS translocation variant 7 ETV Helix-turn-helix 0 0 0 0.451198985095268 1.63127159003123 4.91531866583876 0.0644773612863239 0.233112420774509 0.702410217939167 0 0 SMESG000035130.1 MSTRG.11027 SMEST035130001 spdef-1 SAM pointed domain-containing Ets transcription factor 1 SPDEF Helix-turn-helix 0 0 0 0.693987196704276 1.81630443342822 9.75627265745838 0.0565755153956458 0.148069532009516 0.795354952594838 0 0 SMESG000080567.1 MSTRG.23616 SmMSTRG.23616 spdef-2 SAM pointed domain-containing Ets transcription factor 2 SPDEF Helix-turn-helix 0 0 0 9.05309182991369 11.1420418444307 10.4847057402373 0.295082764533992 0.363171452557702 0.341745782908305 0 0 SMESG000003750.1 MSTRG.2025 SmMSTRG.2025 irf Interferon regulatory factor IRF Helix-turn-helix 0 0 0 9.47260323717621 11.7131072212179 5.44732902229747 0.355671129614915 0.439796112257846 0.204532758127238 0 0 SMESG000080027.1 MSTRG.23472 SMEST080027001 fli-1 elf-like Friend leukemia integration 1 FLI Helix-turn-helix 1 Behavioural defects Neoblasts, CNS (Scimone et al., 2014; Roberts-Galbraith et al., 2016) 0.526056691238133 9.85843816180775 3.09011216991875 0.039040596162959 0.731630847935388 0.229328555901653 MA0475.2 1.26895E-54 SMESG000078333.1 MSTRG.22994 SMEST078333001 fli-2 fli1-like Friend leukemia integration 2 FLI Helix-turn-helix 1 0 Neoblasts (Scimone et al., 2014) 2.78695572062837 14.1918508820369 4.75879552642539 0.128208976504298 0.652871038753831 0.218919984741871 MA0474.2 1.08391E-56 SMESG000014306.1 MSTRG.4327 SmMSTRG.4327 fli-3 fli-2 Friend leukemia integration 3 FLI Helix-turn-helix 1 0 0 (Roberts-Galbraith et al., 2016) 0.342296657613841 1.29273848234407 1.39720590301991 0.112885701618789 0.426331041635968 0.460783256745243 MA0474.2 8.35057E-49 SMESG000077205.1 MSTRG.22628 SMEST077205001 tead1 TEA domain transcription factor 1 TEAD Helix-turn-helix 0 0 0 28.0265311543181 14.0298442492538 7.74187846345713 0.562801483545073 0.28173365850771 0.155464857947217 MA0243.1 4.34144E-39 SMESG000021468.1 MSTRG.6831 SMEST021468001 tead3 sd2 TEA domain transcription factor 3 TEAD Helix-turn-helix 1 0 0 (Cheng et al., 2018) 6.40162689776701 13.2817048748231 6.43180311462944 0.245130914521904 0.508582664121066 0.24628642135703 0 0 SMESG000015058.1 MSTRG.4536 SmMSTRG.4536 kdm5b Lysine-specific demethylase 5B KDM Helix-turn-helix 0 0 0 20.9565734335612 45.4964723865034 10.1553607817354 0.273554487857849 0.593883548877185 0.132561963264966 MA0372.1 3.09428E-32 SMESG000011244.1 MSTRG.4189 SMEST011244001 soxB1-1 soxB/soxB-1 SRY-box containing gene B1-1 SOX Alpha-helical 1 Eye defects Anterior photoreceptors, Neoblasts (Lapan and Reddien, 2012; Önal et al. 2012; van Wolfswinkel et al., 2014) 8.71371769334947 5.4446031108962 1.28282960269131 0.564317907908909 0.352603463304793 0.0830786287862979 0 0 SMESG000067682.1 MSTRG.20007 SmMSTRG.20007 soxB1-2 SRY-box containing gene B1-2 SOX Alpha-helical 1 Neural and behavioural defects CNS (Ross et al., 2018) 0.231877504984002 3.0806276354062 0.769411389777027 0.0568060378673401 0.75470128128269 0.18849268084997 0 0 SMESG000077970.1 MSTRG.21711 SMEST077970001 soxB2-1 SOXB2-2, SOXB-2 SRY-box containing gene B2-1 SOX Alpha-helical 1 Brain defects CNS, Neoblasts (Labbé et al., 2012; Önal et al., 2012; Roberts-Galbraith et al., 2016) 0.646824375150321 1.11983673048629 0.763997137665821 0.255595308794536 0.442508083993568 0.301896607211896 0 0 SMESG000010063.1 MSTRG.3856 SmMSTRG.3856 soxP-1 soxP-1 SRY-box containing gene P-1 SOX Alpha-helical 1 Stem cell defects Neoblasts (Wagner et al., 2012; Önal et al., 2012; van Wolfswinkel et al., 2014; Roberts-Galbraith et al., 2016; Mihaylova et al., 2018) 105.017225112941 50.851309219809 5.61549942373687 0.650325748434695 0.314899919434087 0.0347743321312178 0 0 SMESG000074761.1 MSTRG.21964 SmMSTRG.21964 soxP-2 soxP-2 SRY-box containing gene P-2 SOX Alpha-helical 1 0 Neoblasts (Wagner et al., 2012; Önal et al., 2012; van Wolfswinkel et al., 2014; Mihaylova et al., 2018; Raz et al., 2021) 30.6784049519923 25.3717168550931 3.46196230926786 0.515498749665906 0.426328824335715 0.0581724259983788 0 0 SMESG000051170.1 MSTRG.13411 SmMSTRG.13411 soxP-3 sox9-1 SRY-box containing gene P-3 SOX Alpha-helical 1 Epidermal defects Neoblasts (Wagner et al., 2012; Önal et al., 2012; van Wolfswinkel et al., 2014; Zhu et al., 2015; Wurtzel et al., 2017; Cheng et al., 2018; Mihaylova et al., 2018; Raz et al., 2021) 40.1329622321347 229.039585893439 164.796637501603 0.0924788292840059 0.527778454044909 0.379742716671085 0 0 SMESG000050484.1 MSTRG.15514 SmMSTRG.15514 soxP-4 SOXD-2 SRY-box containing gene P-4 SOX Alpha-helical 1 0 0 (Önal et al., 2012) 3.22814215590758 8.60057154869255 5.01837012924335 0.191614298815483 0.510508028185577 0.29787767299894 0 0 SMESG000066725.1 MSTRG.19831 SMEST066725002 soxP-5 soxD-1 SRY-box containing gene P-5 SOX Alpha-helical 1 Visual neuron defects Faintly ubiquitous (Önal et al., 2012; van Wolfswinkel et al., 2014; Scimone et al., 2020) 24.4297735920228 7.83768042797526 3.59701415848689 0.68116926955237 0.218536083930475 0.100294646517155 0 0 SMESG000045451.1 MSTRG.14130 SmMSTRG.14130 nf-ya1 NF-YA Nuclear transcription factor Y subunit A1 NF-Y Alpha-helical 1 Lesions Male gonads, Somatic tissue (Zhu et al., 2015; Iyer et al., 2016) 69.8943194632462 67.0670874137105 31.9244400355361 0.413855398430524 0.39711490713879 0.189029694430686 MA0060.2 1.43588E-27 SMESG000010136.1 MSTRG.3824 SMEST010136002 nf-ya2 Nuclear transcription factor Y subunit A2 NF-Y Alpha-helical 1 0 Male gonads, Somatic tissue (Iyer et al., 2016) 8.27531916474363 8.19667743181996 18.7348098479335 0.235048844256565 0.232815136037455 0.53213601970598 MA0060.2 8.27296E-29 SMESG000031441.1 MSTRG.10306 SMEST031441001 nf-ya3 Nuclear transcription factor Y subunit A3 NF-Y Alpha-helical 0 0 0 16.4848993186133 1.209146797008 0.33987422589782 0.914105142222485 0.0670484716639347 0.0188463861135803 0 0 SMESG000017262.1 MSTRG.5449 SmMSTRG.5449 nf-yb1 NF-YB Nuclear transcription factor Y subunit B1 NF-Y Alpha-helical 0 0 (Iyer et al., 2016) 4.36595754979289 6.32014781185193 5.5615011765433 0.268713889613908 0.388989467279205 0.342296643106887 0 0 SMESG000040141.1 MSTRG.12597 SmMSTRG.12597 nf-yb2 Nuclear transcription factor Y subunit B2 NF-Y Alpha-helical 1 Lesions 0 (Iyer et al., 2016) 60.2137323953761 51.8435836041654 40.4536401792895 0.394815781790593 0.339933503160093 0.265250715049314 0 0 SMESG000077821.1 MSTRG.21651 SMEST077821002 nf-yc Nuclear transcription factor Y subunit C NF-Y Alpha-helical Lesions Male gonads, Somatic tissue (Iyer et al., 2016) 50.0065268541934 54.8614146939212 42.9189638079766 0.338369131782705 0.371219727226395 0.2904111409909 0 0 SMESG000040479.1 MSTRG.12930 SmMSTRG.12930 mef2-1 Mef2 Myocyte enhancer factor 2 protein 1 MEF Alpha-helical 1 0 CNS (Reddien et al., 2005; van Wolfswinkel et al., 2014) 20.4242857895164 17.1091726549179 20.9765992394474 0.349073075604621 0.29241421615674 0.358512708238639 MA0052.3 4.1272E-43 SMESG000006802.1 MSTRG.2947 SmMSTRG.2947 mef2-2 Myocyte enhancer factor 2 protein 2 MEF Alpha-helical 0 0 0 6.62140514372102 22.1920869863992 9.54051493058651 0.172639201250619 0.57861195445038 0.248748844299001 MA0660.1 9.55142E-47 SMESG000074732.1 MSTRG.21952 SmMSTRG.21952 srf Serum response factor SRF Alpha-helical 1 0 Ubiquitous (van Wolfswinkel et al., 2014) 32.5399765628905 29.7548539142512 29.6011419436524 0.354095785764028 0.323788443937487 0.322115770298485 0 0 SMESG000001287.1 MSTRG.1359 SmMSTRG.1359 nfat5 Nuclear factor of activated T cells 5 NFAT Immunoglobulin-fold 0 0 0 0.992240654538557 1.25417673561248 2.84982972901561 0.194700263024296 0.246098100481745 0.559201636493959 0 0 SMESG000027221.1 MSTRG.310 SMEST027221003 rbpj Recombination signal binding protein for immunoglobulin kappa J region RBPJ Immunoglobulin-fold 0 0 0 6.26598725466856 18.0563392457204 7.21760189714432 0.198668404559809 0.572491446972739 0.228840148467452 0 0 SMESG000014122.1 MSTRG.5008 SMEST014122001 stat6 Signal transducer and activator of transcription 6 STAT Immunoglobulin-fold 0 0 0 11.4556562002756 8.45076821750176 9.74619269489213 0.386328672330951 0.284992322444653 0.328679005224396 0 0 SMESG000078256.1 MSTRG.21524 SMEST078256002 p53 Cellular tumor antigen p53 p53 Immunoglobulin-fold 1 Hyper-proliferation and terminal depletion Stem cell progeny (Pearson and Sánchez Alvarado, 2010; van Wolfswinkel et al., 2014; Cheng et al., 2018; Raz et al., 2021) 78.782379744503 156.568022531302 164.774637283174 0.196894400388782 0.391297737087068 0.41180786252415 0 0 SMESG000014779.1 MSTRG.4469 SmMSTRG.4469 runt-1 runt Runt-related transcription factor 1 RUNT Immunoglobulin-fold 1 Loss of neural precursors Neoblasts (Sandmann et al., 2011; Wenemoser et al., 2012; van Wolfswinkel et al., 2014; Zhu et al., 2015; Roberts-Galbraith et al., 2016; Owlarn et al., 2017; Fincher et al., 2018) 28.3083385144141 1.63426474003774 0.784465599074806 0.921283401594782 0.0531864834823047 0.0255301149229133 0 0 SMESG000049171.1 MSTRG.15139 SMEST049171002 runt-2 runx2 Runt-related transcription factor 2 RUNT Immunoglobulin-fold 1 0 Ubiquitous (van Wolfswinkel et al., 2014; Zhu et al., 2015; Owlarn et al., 2017) 31.9459280240942 24.3167749342395 31.5571292848629 0.363766671013757 0.276893889604569 0.359339439381674 0 0 SMESG000064684.1 MSTRG.17627 SMEST064684001 tbx-1/10 T-box transcription factor 1/10 TBX Immunoglobulin-fold 1 0 0 (Tewari et al., 2019) 2.41023178672206 1.56471166686224 7.53154998561273 0.209467097813794 0.135985100511336 0.65454780167487 MA0805.1 1.20212E-68 SMESG000080056.1 MSTRG.23477 SMEST080056002 tbx-2/3a tbx-2/3a T-box transcription factor 2/3a TBX Immunoglobulin-fold 1 0 0 (Tewari et al., 2019) 3.64806507447401 14.1540109786513 6.29629792187915 0.151382208536472 0.587342988092567 0.261274803370961 MA0688.1 1.73129E-73 SMESG000023378.1 MSTRG.8305 SmMSTRG.8305 tbx-2/3b tbx-2/3b T-box transcription factor 2/3b TBX Immunoglobulin-fold 1 0 0 (Tewari et al., 2019) 4.31443708780864 5.05391466746275 8.0734147597545 0.247362392111591 0.289759335048365 0.462878272840044 0 0 SMESG000061015.1 MSTRG.18243 SMEST061015001 tbx-2/3c tbx2 T-box transcription factor 2/3c TBX Immunoglobulin-fold 1 0 0 (Wurtzel et al., 2017; Tewari et al., 2019) 3.15002683117714 3.58866454667052 1.55532441749153 0.379795132889341 0.432681180651617 0.187523686459042 MA0688.1 1.24718E-120 SMESG000071435.1 MSTRG.21005 SMEST071435001 tbx-20 tbx-20 T-box transcription factor 20 TBX Immunoglobulin-fold 1 0 0 (Tewari et al., 2019) 3.39739349423873 3.29395150421185 2.26030071311448 0.379527251603521 0.367971612187045 0.252501136209434 MA0689.1 2.0197E-101 SMESG000011457.1 MSTRG.4208 SMEST011457001 smad1 smad1 SMAD family member 1 SMAD Beta-hairpin 1 0 Ubiquitous (van Wolfswinkel et al., 2014) 36.7610321739342 41.2533538537031 27.2647208508782 0.349176899993593 0.391847490702086 0.258975609304321 MA0535.1 0 SMESG000029614.1 MSTRG.9898 SmMSTRG.9898 smad4-1 smad-4 SMAD family member 4 protein 1 SMAD Beta-hairpin 1 0 Neoblasts (Molinaro et al., 2016) 0.139349830031773 3.40185026220812 0.644746392870405 0.0332899215332662 0.812683648562813 0.154026429903921 MA0513.1 4.07209E-56 SMESG000013170.1 MSTRG.4770 SmMSTRG.4770 smad4-2 SMAD family member 4 protein 2 SMAD Beta-hairpin 0 0 0 22.5564082990986 38.1339773781622 35.0552360539263 0.235586838241308 0.398284294244035 0.366128867514657 0 0 SMESG000002697.1 MSTRG.748 SmMSTRG.748 smad6/7-1 smad6/7 SMAD family member 6/7 protein 1 SMAD Beta-hairpin 1 0 Gut (van Wolfswinkel et al., 2014) 34.4589300476288 18.360710930807 15.4996385781977 0.504380758568509 0.268748602882834 0.226870638548658 0 0 SMESG000021574.1 MSTRG.7692 SMEST021574001 smad6/7-2 SMAD family member 6/7 protein 2 SMAD Beta-hairpin 1 0 Photoreceptor neurons (Lapan and Reddien, 2012) 5.55794509945666 7.33845412840784 7.15687896482417 0.277158928632579 0.365947854405341 0.356893216962079 0 0 SMESG000056334.1 MSTRG.16892 SMEST056334001 smad9 SMAD family member 9 SMAD Beta-hairpin 0 0 0 4.30590490323324 17.2956575420581 16.2904253957969 0.113636289584262 0.456446297158987 0.429917413256751 MA0535.1 0 SMESG000010567.1 MSTRG.3965 SmMSTRG.3965 nf-i/a Nuclear factor 1 A-type NF Beta-hairpin 1 0 0 (Lapan and Reddien, 2012) 5.84235006185596 9.9140503294147 15.0368305598204 0.189728387746495 0.321955508506438 0.488316103747067 0 0 SMESG000056241.1 MSTRG.16974 SmMSTRG.16974 gcm-1 GCM2 Glial cells missing 1 GCM Beta-hairpin 1 0 0 (Fincher et al., 2018) 2.74125354463868 7.08624177958307 5.02870661335814 0.184519135924268 0.476988789554474 0.338492074521257 MA0917.1 7.84977E-37 SMESG000036444.1 MSTRG.11405 SmMSTRG.11405 gcm-2 Glial cells missing 2 GCM Beta-hairpin 0 0 0 11.3576433839607 1.01219069919412 0.117774112703933 0.909513111384069 0.0810556099549787 0.0094312786609521 MA0646.1 2.09806E-52 SMESG000068211.1 MSTRG.20269 SMEST068211002 tbp-1 TATA box-binding protein 1 TBP Beta-sheet 0 0 0 1.02470749907739 3.58199020320364 1.81120383285906 0.159663948327468 0.558124829991718 0.282211221680814 0 0 SMESG000081966.1 MSTRG.22902 SmMSTRG.22902 tbp-2 TATA box-binding protein 2 TBP Beta-sheet 0 0 0 29.680000274136 33.2636495770538 20.7045683038402 0.354819276832991 0.397661185267622 0.247519537899387 0 0 SMESG000016335.1 MSTRG.5846 SMEST016335001 tbp-3 TATA box-binding protein 3 TBP Beta-sheet 0 0 0 8.65780488598277 5.38899765896865 1.92521562572111 0.542060796166639 0.337402424752046 0.120536779081315 0 0 SMESG000005716.1 MSTRG.1671 SmMSTRG.1671 tbp-4 TATA box-binding protein 4 TBP Beta-sheet 0 0 0 0.0454779807230933 0.0497224821254756 0 0.47770755900035 0.52229244099965 0 0 0 SMESG000019971.1 MSTRG.6981 SmMSTRG.6981 tbp-5 TATA box-binding protein 5 TBP Beta-sheet 0 0 0 31.6367043910771 13.3247621808411 12.0727348509464 0.554697069509492 0.23362757518157 0.211675355308938 0 0 SMESG000048079.1 MSTRG.14847 SMEST048079001 tbp-6 TATA box-binding protein 6 TBP Beta-sheet 0 0 0 0.109647312597418 0.142085117933924 0 0.43557086532705 0.56442913467295 0 0 0 SMESG000032180.1 MSTRG.10123 SmMSTRG.10123 ybx1-1 yps-1 Y-box-binding protein 1 protein 1 YBX Beta-barrel 1 0 0 (Molinaro et al., 2016) 1248.40093398328 763.904018787349 865.628243329589 0.433783847267526 0.26543493776106 0.300781214971414 0 0 SMESG000008704.1 MSTRG.3360 SMEST008704001 ybx1-2 Y-box-binding protein 1 protein 2 YBX Beta-barrel 1 0 0 420.410088191192 412.880197416117 406.906409115741 0.338986622025367 0.332915092559828 0.328098285414805 0 0 SMESG000058013.1 MSTRG.15845 SmMSTRG.15845 ybx2 Y box binding protein 2 YBX Beta-barrel 0 0 0 5069.36324029088 4097.95133258493 3948.33249688295 0.38651262978702 0.31244751484917 0.301039855363809 0 0 SMESG000032189.1 MSTRG.10125 SMEST032189001 ybx3-1 Y-box-binding protein 3 protein 1 YBX Beta-barrel 0 0 0 669.256901797635 666.780908370488 666.099996861998 0.334271147294491 0.333034472466988 0.332694380238521 0 0 SMESG000076962.1 MSTRG.22567 SMEST076962001 ybx3-2 Y-box-binding protein 3 protein 2 YBX Beta-barrel 0 0 0 0.154523582562836 0.155555465861728 0 0.498336096385526 0.501663903614474 0 0 0 SMESG000073546.1 MSTRG.20385 SMEST073546001 ybx3-3 Y-box-binding protein 3 protein 3 YBX Beta-barrel 0 0 0 661.397236287029 531.873733889911 578.196035816716 0.373361306786539 0.300244786998768 0.326393906214693 0 0 SMESG000064236.1 MSTRG.17403 SMEST064236001 nfx1-1 Transcriptional repressor NF-X1 protein 1 NFX Other 0 0 0 8.95621426864874 14.8362053176999 6.04489542562517 0.300168237827518 0.497236608312313 0.202595153860169 0 0 SMESG000036201.1 MSTRG.11335 SMEST036201001 nfx1-2 Transcriptional repressor NF-X1 protein 2 NFX Other 0 0 0 2.94808053889667 1.69242450442765 1.21996133894425 0.503045380111109 0.28878665860933 0.208167961279561 0 0 SMESG000009225.1 MSTRG.2747 SmMSTRG.2747 tcf1 TCF/LEF transcription factor 1 TCF Other 1 Dorsal-lateral neuronal defects CNS (Wurtzel et al., 2017; Brown et al., 2018) 3.08748455028019 22.7846565737906 6.57494392432183 0.0951544505669896 0.702209660430478 0.202635889002533 0 0 SMESG000059443.1 MSTRG.15807 SmMSTRG.15807 tcf2 tf7-like TCF/LEF transcription factor 2 TCF Other 1 0 Sparse cells in lateral brain (Roberts-Galbraith et al., 2016; Brown et al., 2018) 0.0767663606406012 2.76753144659869 1.1110315356291 0.0194083359402204 0.699696841070555 0.280894822989225 0 0 SMESG000052392.1 MSTRG.15964 SMEST052392001 tcf3 TCF/LEF transcription factor 3 TCF Other 1 0 0 (Brown et al., 2018) 0.188247446405848 0.553689272203341 0.182934197043396 0.203539156891988 0.598666541279072 0.197794301828941 0 0 SMESG000038786.1 MSTRG.12140 SmMSTRG.12140 tcf4 TCF/LEF transcription factor 4 TCF Other 1 0 CNS (Brown et al., 2018) 13.8095303291278 25.0026188755595 12.1276560982893 0.271095074804317 0.49082674593769 0.238078179257992 0 0 SMESG000017328.1 MSTRG.5099 SmMSTRG.5099 tcf5 TCF/LEF transcription factor 5 TCF Other 1 0 CNS (Brown et al., 2018) 5.02420133070743 13.9123883671989 4.02310588577813 0.218827001098295 0.605948293891373 0.175224705010332 0 0 SMESG000080750.1 MSTRG.23684 SmMSTRG.23684 dr1 Protein Dr1 DR Other 0 0 0 51.9724660993793 26.0709943006757 25.2432550465234 0.503186357264505 0.252413819027482 0.244399823708012 0 0 SMESG000010406.1 MSTRG.3987 SmMSTRG.3987 drap1 Dr1-associated corepressor DRAP Other 0 0 0 131.702149965691 84.0808369330729 44.7666231540209 0.505478207927501 0.322705671737674 0.171816120334825 0 0 SMESG000078919.1 MSTRG.23136 SMEST078919002 hr51 Hormone receptor 51 HR Other 0 0 0 0.505217480749537 0.734548863090827 0.427514097578342 0.303018897240612 0.440567072487093 0.256414030272295 MA0164.1 3.95216E-44 SMESG000013159.1 MSTRG.4715 SmMSTRG.4715 dach Dachshund DACH Other 1 No eye defect Scattered in the head (Lapan and Reddien, 2011) 0.902512079723956 5.42826106724947 1.24994391970681 0.119053655714285 0.716061689085915 0.1648846551998 0 0 SMESG000025472.1 SMESG000025472.1 SMEST025472001 jrk-1 Jrk Helix-Turn-Helix Protein 1 JRK Other 0 0 0 0.3795315841657 0.878012494813222 0.0646189846486542 0.287053537197138 0.664072775111602 0.0488736876912603 0 0 SMESG000027161.1 MSTRG.41 jrk-2 Jrk Helix-Turn-Helix Protein 2 JRK Other 0 0 0 0.163028956559855 0.228321512718709 0.0348845628454421 0.382486056454469 0.535670452944568 0.0818434906009625 0 0 SMESG000067290.1 MSTRG.19902 SMEST067290001 ski-1 ski Ski oncogene 1 SKI Other 1 0 Neoblasts (Molinaro et al., 2016; Stückemann et al., 2017) 2.10968196338152 30.6114190500169 23.5613906672744 0.0374838053608414 0.543888838889639 0.41862735574952 MA0508.1 0.77924 SMESG000044463.1 MSTRG.13841 SMEST044463001 ski-3 Ski oncogene 3 SKI Other 1 0 Neoblasts (Molinaro et al., 2016) 12.0643911429258 15.9789605967695 11.8478081752389 0.302432698589173 0.400563950279806 0.297003351131021 0 0 SMESG000002232.1 MSTRG.1590 SmMSTRG.1590 ski-4 Ski oncogene 4 SKI Other 0 0 0 1.73917603180917 2.33038376917236 129.520156241376 0.0130187867998591 0.0174443350746659 0.969536878125475 0 0 - MSTRG.16230 SmMSTRG.16230 ski-5 Ski oncogene 5 SKI Other 0 0 0 0 0 0 0 0 SMESG000070642.1 MSTRG.20769 SMEST070642001 ski-6 Ski oncogene 6 SKI Other 0 0 0 0.290551782125984 0.770395645469202 3.20589197932381 0.0680953170290011 0.180554169491345 0.751350513479654 0 0 SMESG000075612.1 MSTRG.22210 SMEST075612001 ski-7 Ski oncogene 7 SKI Other 0 0 0 0.0846445726365871 0.0958344704586461 0.257310064598774 0.193345542748746 0.218905561546382 0.587748895704872 0 0 SMESG000018825.1 MSTRG.6031 SmMSTRG.6031 ski-8 Ski oncogene 8 SKI Other 0 0 0 6.50087339133842 14.201349091486 14.4588588072316 0.184888324045283 0.403893980800367 0.41121769515435 0 0 - MSTRG.8078 SmMSTRG.8078 ski-9 Ski oncogene 9 SKI Other 0 0 0 0.376289957188442 1.21419720465405 0.0728911072116736 0.226220315720735 0.729958559182374 0.0438211250968916 0 0 SMESG000037051.1 SMESG000037051.1 SMEST037051001 ski-10 Ski oncogene 10 SKI Other 0 0 0 0.181816766693697 0.310298731726105 0.0662010595798438 0.32565175452635 0.55577562098078 0.11857262449287 0 0 SMESG000073656.1 MSTRG.20452 skor2 SKI family transcriptional corepressor 2 SKI Other 0 0 0 0.0281776447178477 0.900946725237591 0.25897608386367 0.0237165507573637 0.758308543980038 0.217974905262598 0 0 SMESG000071434.1 MSTRG.21004 SMEST071434001 tigd1-1 Tigger transposable element-derived 1 protein 1 TIGD Other 0 0 0 0.650905000980319 1.22582167651259 0.474304928445737 0.276859315432489 0.521397361658685 0.201743322908826 0 0 SMESG000007787.1 MSTRG.3137 SmMSTRG.3137 tigd1-2 Tigger transposable element-derived 1 protein 2 TIGD Other 0 0 0 13.1462835374463 6.58673449850857 7.98796209089525 0.474235884780748 0.237608283270214 0.288155831949038 0 0 SMESG000008701.1 MSTRG.3355 SMEST008701001 tigd1-3 Tigger transposable element-derived 1 protein 3 TIGD Other 0 0 0 0.0830259602333684 0.24032726500882 0.0450351151535566 0.225376189007983 0.652374786755319 0.122249024236699 0 0 SMESG000067795.1 SMESG000067795.1 SMEST067795001 tigd1-4 Tigger transposable element-derived 1 protein 4 TIGD Other 0 0 0 0.0139502028029245 0.0026855350926777 0.0177635757000401 0.405537243181844 0.0780694383686167 0.516393318449539 0 0 SMESG000046446.1 SMESG000046446.1 SMEST046446001 tigd2-1 Tigger transposable element-derived 2 protein 1 TIGD Other 0 0 0 0.218823614025129 0.716268386340495 0.0751743916119556 0.216599914401573 0.708989620983443 0.0744104646149843 0 0 SMESG000022824.1 SMESG000022824.1 SMEST022824001 tigd2-2 Tigger transposable element-derived 2 protein 2 TIGD Other 0 0 0 0.0575612436076775 0.0383652719146051 0 0.600055608131692 0.399944391868308 0 0 0 SMESG000027639.1 SMESG000027639.1 SMEST027639001 tigd2-3 Tigger transposable element-derived 2 protein 3 TIGD Other 0 0 0 0.311055306028729 0.285210802629561 0.066464869091601 0.469353804895051 0.430356829852606 0.100289365252343 0 0 SMESG000064026.1 MSTRG.17767 SMEST064026001 tigd4-1 Tigger transposable element-derived 4 protein 1 TIGD Other 0 0 0 0.0236334923350377 0.103398899519762 0 0.186043039810282 0.813956960189718 0 0 0 SMESG000068917.1 SMESG000068917.1 SMEST068917001 tigd4-2 Tigger transposable element derived 4 TIGD Other 0 0 0 0.0881706459491759 0.130714228012425 0 0.402817446237258 0.597182553762742 0 0 0 SMESG000002311.1 SMESG000002311.1 SMEST002311001 tigd4-3 Tigger transposable element derived 4 TIGD Other 0 0 0 0.575154969570909 1.30913366950085 0.135918842198704 0.284700940325796 0.648019414658125 0.0672796450160788 0 0 SMESG000006066.1 SMESG000006066.1 SMEST006066001 tigd4-4 Tigger transposable element derived 4 TIGD Other 0 0 0 0.0328419472190922 0.0698885120264224 0.101446105148655 0.160850719163291 0.342294485333293 0.496854795503415 0 0 SMESG000017329.1 SMESG000017329.1 SMEST017329001 tigd4-5 Tigger transposable element derived 4 TIGD Other 0 0 0 0.400139718635556 0.529798019907154 0.181677439788743 0.359962446029362 0.476602002414529 0.163435551556108 0 0 SMESG000013943.1 SMESG000013943.1 SMEST013943001 tigd5 Tigger transposable element derived 5 TIGD Other 0 0 0 0.121708311667219 0.220659868512483 0.0494300816299384 0.310640254260118 0.563197670896491 0.126162074843391 0 0 SMESG000035581.1 SMESG000035581.1 SMEST035581001 tigd6 Tigger transposable element derived 6  TIGD Other 0 0 0 0.0095523555375183 0 0 1 0 0 0 0 SMESG000059729.1 SMESG000059729.1 SMEST059729001 tigd7 Tigger transposable element derived 7 TIGD Other 0 0 0 0.27026564168607 0.0591822410345812 0.332572797588831 0.408243503148158 0.0893963629760245 0.502360133875817 0 0 SMESG000038141.1 MSTRG.12309 SMEST038141001 gtf2a1 Transcription initiation factor IIA subunit 1 GTF Other 0 0 0 10.2767873196413 10.6399070421244 8.47524189758148 0.349646489056095 0.362000888551217 0.288352622392687 MA0052.3 4.66628E-44 - MSTRG.22941 SmMSTRG.22941 gtf2a2-1 Transcription initiation factor IIA subunit 2 protein 1 GTF Other 0 0 0 73.722144906327 27.1489738765056 25.7962663071184 0.58201363242775 0.214332788643471 0.203653578928779 0 0 SMESG000078406.1 MSTRG.22943 SmMSTRG.22943 gtf2a2-2 Transcription initiation factor IIA subunit 2 protein 2 GTF Other 0 0 0 60.6198841534388 95.5151055721606 85.0601942765508 0.251331237828108 0.396007515520331 0.35266124665156 0 0 SMESG000019348.1 SMESG000019348.1 SMEST019348001 gtf2b-1 General transcription factor IIB protein 1 GTF Other 0 0 0 0 0.0154032564453084 0 0 1 0 0 0 SMESG000019400.1 SMESG000019400.1 SMEST019400001 gtf2b-2 General transcription factor IIB protein 2 GTF Other 0 0 0 0.0305591329913961 0 0.0276056370998508 0.525389044664941 0 0.474610955335059 0 0 SMESG000077013.1 MSTRG.22578 SMEST077013001 gtf2b-3 General transcription factor IIB protein 3 GTF Other 0 0 0 14.4298719601952 1.35980008175498 1.21329418956496 0.848667918509966 0.079974285853405 0.071357795636629 0 0 SMESG000033954.1 MSTRG.11128 SmMSTRG.11128 gtf2b-4 General transcription factor IIB protein 4 GTF Other 0 0 0 18.4550255132757 18.8350360368488 7.85267581433284 0.408814941023184 0.417232917994875 0.173952140981941 MA0071.1 2.89783E-24 SMESG000077014.1 MSTRG.22579 SMEST077014001 gtf2b-5 General transcription factor IIB protein 5 GTF Other 0 0 0 0.0526861973643752 0.34595245369801 0.100578608459125 0.105537611850347 0.692989769683842 0.20147261846581 0 0 SMESG000077015.1 MSTRG.22580 SMEST077015001 gtf2b-6 General transcription factor IIB protein 6 GTF Other 0 0 0 0.102509326699319 0.113096200641254 0.0771581856126586 0.350143553192654 0.386305391130631 0.263551055676714 0 0 SMESG000077016.1 MSTRG.22582 SmMSTRG.22582 gtf2b-7 General transcription factor IIB protein 7 GTF Other 0 0 0 186.73730786888 134.691040451545 133.334249485986 0.410625915081021 0.296178799886445 0.293195285032534 0 0 SMESG000077025.1 MSTRG.22583 SMEST077025001 gtf2b-8 General transcription factor IIB protein 8 GTF Other 0 0 0 7.80835531729417 10.3467057263034 6.43177671746328 0.317582740536913 0.420822955227284 0.261594304235803 0 0 SMESG000021979.1 MSTRG.7811 SmMSTRG.7811 gtf2e2 Transcription initiation factor IIE subunit beta GTF Other 0 0 0 98.3759846056806 59.3151868728297 42.7391801960389 0.490823788831242 0.295939144831434 0.213237066337323 0 0 SMESG000026639.1 MSTRG.22 SMEST026639001 gtf2f2-1 General transcription factor IIF subunit 2 protein 1 GTF Other 0 0 0 211.105726475187 131.740159212271 153.599608599073 0.425234449511076 0.265366814138583 0.309398736350341 0 0 SMESG000023050.1 MSTRG.7532 SMEST023050002 gtf2f2-2 General transcription factor IIF subunit 2 protein 2 GTF Other 0 0 0 7.61108443156509 2.69014604840417 1.29118768043263 0.656557098463159 0.232060818647255 0.111382082889586 0 0 SMESG000070633.1 SMESG000070633.1 SMEST070633001 gtf2f2-3 General transcription factor IIF subunit 2 protein 3 GTF Other 0 0 0 0.0596299582510237 0.0862874403876739 0.0287704319141904 0.341351530111139 0.49395221243846 0.164696257450401 0 0 SMESG000070634.1 SMESG000070634.1 SMEST070634001 gtf2f2-4 General transcription factor IIF subunit 2 protein 4 GTF Other 0 0 0 0 0.0558392971540021 0 0 1 0 0 0 SMESG000072537.1 MSTRG.21228 SmMSTRG.21228 gtf2h3 General transcription factor IIH subunit 3 GTF Other 0 0 0 43.2033285452505 35.3048991433033 30.0410031904008 0.398006767946863 0.325243199398368 0.276750032654769 0 0 SMESG000022992.1 MSTRG.7507 SmMSTRG.7507 gtf2h4 General transcription factor IIH subunit 4 GTF Other 0 0 0 19.5965675270369 10.9094708255681 8.96885239948576 0.496431203574615 0.276364813624983 0.227203982800401 0 0 SMESG000018316.1 MSTRG.6506 SMEST018316006 gtf3c1-1 General transcription factor 3C polypeptide 1 protein 1 GTF Other 0 0 0 2.91114535567172 2.64979233837428 2.27919388241086 0.371313329027997 0.337978044441415 0.290708626530587 0 0 SMESG000018366.1 MSTRG.6516 SmMSTRG.6516 gtf3c1-2 General transcription factor 3C polypeptide 1 protein 2 GTF Other 0 0 0 8.40741821519527 7.6247263572994 4.60836623847042 0.407326073089669 0.36940589441463 0.223268032495701 0 0 - MSTRG.1126 SmMSTRG.1126 gtf3c5-1 General transcription factor 3C polypeptide 5 protein 1 GTF Other 0 0 0 0.746669921736121 0.629025031990521 0.808891915749358 0.341789988839043 0.28793775188322 0.370272259277737 0 0 SMESG000015993.1 MSTRG.5716 SMEST015993001 gtf3c5-2 General transcription factor 3C polypeptide 5 protein 2 GTF Other 0 0 0 0.955828163592423 0.8617097362601 3.41183964641763 0.182780484892349 0.16478246763321 0.65243704747444 0 0 SMESG000016003.1 MSTRG.5719 SMEST016003001 gtf3c5-3 General transcription factor 3C polypeptide 5 protein 3 GTF Other 0 0 0 0.36381430750383 0.667084595066899 0.542804676717947 0.231183503864353 0.423894692651347 0.344921803484299 0 0 SMESG000065945.1 MSTRG.19615 SmMSTRG.19615 gtf2ird2a General transcription factor II-I repeat domain-containing protein 2A GTF Other 0 0 0 3.73285411949514 7.68985002219157 5.64948294269525 0.218651195716455 0.4504314522904 0.330917351993145 0 0 SMESG000026051.1 MSTRG.559 SmMSTRG.559 gtf2ird2b General transcription factor II-I repeat domain-containing protein 2B GTF Other 0 0 0 5.9212386704797 4.07924388795818 4.64026696037927 0.404435487600507 0.278622613051012 0.316941899348481 0 0