Annotation Cluster 1 Enrichment Score: 3.6487241024884702 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF001630:serpin 12 1.0714285714285714 5.703672437609278E-7 SERPINB5, SERPINB8, SERPINB7, SERPINE1, SERPINB10, SERPINB2, SERPINB11, SERPINB4, SERPINB12, SERPIND1, SERPINB3, SERPINB13 395 33 7396 6.808745684695052 2.155756398615205E-4 2.155756398615205E-4 7.889971084695802E-4 INTERPRO IPR000215:Protease inhibitor I4, serpin 13 1.1607142857142858 9.828786771079073E-7 HMSD, SERPINB5, SERPINB8, SERPINB7, SERPINE1, SERPINB2, SERPINB10, SERPINB11, SERPINB12, SERPINB4, SERPINB13, SERPINB3, SERPIND1 920 40 16659 5.8849728260869565 0.001289687973991538 0.001289687973991538 0.001606767385575747 SMART SM00093:SERPIN 13 1.1607142857142858 1.1898479969480089E-6 HMSD, SERPINB5, SERPINB8, SERPINB7, SERPINE1, SERPINB2, SERPINB10, SERPINB11, SERPINB12, SERPINB4, SERPINB13, SERPINB3, SERPIND1 513 40 9079 5.7518031189083825 3.235864822968004E-4 3.235864822968004E-4 0.001566210569126092 UP_SEQ_FEATURE site:Reactive bond 13 1.1607142857142858 2.8848004818525847E-6 SERPINB8, SERPINB7, SERPINE1, SERPINB2, TFPI, SERPINB10, SERPINB11, SERPINB12, SERPINB4, SERPINB13, SERPINB3, SERPIND1, TFPI2 1024 45 19113 5.392122395833334 0.007426620548086849 0.007426620548086849 0.005108089768002255 SP_PIR_KEYWORDS Serine protease inhibitor 14 1.25 2.961499384056673E-4 HMSD, SERPINB8, SERPINB7, SERPINE1, SERPINB2, TFPI, SERPINB10, SERPINB11, SERPINB12, SERPINB4, SERPINB13, SERPINB3, SERPIND1, TFPI2 1027 80 19235 3.2776290165530675 0.15208929233425317 0.15208929233425317 0.4320661977330609 GOTERM_MF_FAT GO:0004867~serine-type endopeptidase inhibitor activity 15 1.3392857142857142 5.44269401130392E-4 HMSD, SERPINB5, SERPINB8, SERPINB7, SERPINE1, SERPINB2, TFPI, SERPINB10, SERPINB11, SERPINB12, SERPINB4, SERPIND1, SERPINB13, SERPINB3, TFPI2 725 92 12983 2.9197151424287857 0.3762527450102173 0.3762527450102173 0.8409546944795343 SP_PIR_KEYWORDS serine proteinase inhibitor 7 0.625 8.095340610726203E-4 SERPINB5, SERPINB10, TFPI, SERPINB4, SERPIND1, SERPINB13, TFPI2 1027 22 19235 5.959325484641941 0.3630684488904954 0.13960557523200479 1.176946943184587 SP_PIR_KEYWORDS protease inhibitor 14 1.25 0.004539199848490984 HMSD, SERPINB8, SERPINB7, SERPINE1, SERPINB2, TFPI, SERPINB10, SERPINB11, SERPINB12, SERPINB4, SERPINB13, SERPINB3, SERPIND1, TFPI2 1027 107 19235 2.450563750693882 0.9206661234866877 0.30372658899700156 6.434560130170097 GOTERM_MF_FAT GO:0004866~endopeptidase inhibitor activity 16 1.4285714285714286 0.015297521828080292 HMSD, SERPINB5, SERPINB8, TNFAIP8, SERPINB7, SERPINE1, SERPINB2, TFPI, SERPINB10, SERPINB11, SERPINB12, SERPINB4, SERPIND1, SERPINB13, SERPINB3, TFPI2 725 145 12983 1.9760095124851367 0.9999984315821087 0.9309613393380073 21.268886644298323 GOTERM_MF_FAT GO:0030414~peptidase inhibitor activity 16 1.4285714285714286 0.023755948134930503 HMSD, SERPINB5, SERPINB8, TNFAIP8, SERPINB7, SERPINE1, SERPINB2, TFPI, SERPINB10, SERPINB11, SERPINB12, SERPINB4, SERPIND1, SERPINB13, SERPINB3, TFPI2 725 153 12983 1.8726887536623844 0.9999999991146123 0.9261429961522066 31.13033519031656 GOTERM_MF_FAT GO:0004857~enzyme inhibitor activity 20 1.7857142857142856 0.1765385972939458 HMSD, ANXA5, SERPINB5, SERPINB8, PRKRIP1, TNFAIP8, SERPINB7, SERPINE1, SERPINB10, LMTK2, SERPINB2, TFPI, SERPINB11, SERPINB12, SCG5, SERPINB4, SERPIND1, SERPINB3, SERPINB13, TFPI2 725 270 12983 1.3264878671775224 1.0 0.9800871941236808 95.08591849988561 Annotation Cluster 2 Enrichment Score: 2.0565636567107175 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005626~insoluble fraction 66 5.892857142857142 0.004032968846487607 CYP3A4, SEPT5, ALS2, CYP3A5, CYP3A7, MAEA, VAPA, SCN3A, HPS4, LSS, CYP3A43, DGCR2, SLC23A1, DES, ATP8B1, RAPGEF4, SLC4A3, SLC1A1, SLC12A6, ABCB11, SCN2A, DHRS9, CYB5A, PTPRN, MAPK1, DOC2A, PSEN2, AVEN, STEAP2, DEGS1, GALNT3, SNAP29, TPST2, SCN1A, GAL3ST4, NAPG, ATG12, CYP51A1, CHKB, COMT, LMAN1, ATF2, FMO5, BCL2, RAC1, GRID2IP, YES1, ACSL6, CPT1B, MLC1, SEC11C, SLC12A2, DLGAP4, EPHX1, ABCB1, CAPN2, ABCB4, PPP1R9A, P2RX6, KREMEN1, ARSA, SPCS3, ABCC1, JAK2, LRP2, VLDLR, ABCC6 713 839 12782 1.4102342500171345 0.8579906678392385 0.47827822678516463 5.626584280765712 GOTERM_CC_FAT GO:0005624~membrane fraction 63 5.625 0.006300500782172683 CYP3A4, SEPT5, ALS2, CYP3A5, CYP3A7, MAEA, VAPA, SCN3A, HPS4, LSS, CYP3A43, DGCR2, SLC23A1, ATP8B1, RAPGEF4, SLC4A3, SLC1A1, SLC12A6, ABCB11, SCN2A, DHRS9, CYB5A, PTPRN, DOC2A, PSEN2, AVEN, STEAP2, DEGS1, GALNT3, SNAP29, TPST2, SCN1A, GAL3ST4, NAPG, ATG12, CYP51A1, CHKB, COMT, LMAN1, ATF2, FMO5, BCL2, RAC1, GRID2IP, YES1, ACSL6, CPT1B, MLC1, SEC11C, SLC12A2, DLGAP4, EPHX1, ABCB1, ABCB4, PPP1R9A, P2RX6, KREMEN1, ARSA, SPCS3, ABCC1, JAK2, LRP2, VLDLR, ABCC6 713 809 12782 1.3960510872599108 0.9527720308470669 0.4569499547975061 8.659335213185715 GOTERM_CC_FAT GO:0000267~cell fraction 76 6.785714285714286 0.02662619405223621 ALS2, CYP3A4, SEPT5, CYP3A5, INSL4, MAEA, CYP3A7, VAPA, SCN3A, HPS4, LSS, CYP3A43, DGCR2, SLC23A1, DES, SERPINE1, ATP8B1, RAPGEF4, SLC4A3, SLC1A1, SLC12A6, ABCB11, SCN2A, DHRS9, CYB5A, PTPRN, MAPK1, DOC2A, PSEN2, AVEN, STEAP2, CRYBA4, DEGS1, GALNT3, SNAP29, TPST2, GAL3ST4, SCN1A, NAPG, ATG12, CYP51A1, PPP4R1, CHKB, ASNS, COMT, LMAN1, ATF2, ADCYAP1, FMO5, BCL2, RAC1, GRID2IP, YES1, ACSL6, ACTB, CPT1B, ACTC1, MLC1, SEC11C, SLC12A2, HTT, DLGAP4, EPHX1, ABCB1, CAPN2, ABCB4, PPP1R9A, P2RX6, MAPK12, KREMEN1, ARSA, SPCS3, ABCC1, JAK2, LRP2, VLDLR, ABCC6 713 1083 12782 1.2580399104352746 0.9999978169014542 0.6058621930769325 32.072881601537304 Annotation Cluster 3 Enrichment Score: 2.030368644536883 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF003152:G protein-coupled olfactory receptor, class II 39 3.482142857142857 2.2281098355323972E-5 OR13G1, OR2AK2, OR2L8, OR1C1, OR2L5, OR2T2, OR6F1, OR2T1, OR2T4, OR2T3, OR2L3, OR2L13, OR2L2, OR2G3, OR2G2, OR2T10, OR2T11, OR2G6, OR2T12, OR2T5, OR2T33, OR2T6, OR2T35, OR2T34, OR2T8, OR2C3, OR14C36, OR2M7, OR2B11, OR11L1, OR2M2, OR2W3, OR2M3, OR2AE1, OR2M4, OR2M5, OR14A16, OR2T29, OR2T27, OR14I1 395 353 7396 2.068662817800409 0.008386980392113053 0.004202319942506083 0.030817466406518612 SP_PIR_KEYWORDS olfaction 40 3.571428571428571 3.3066840169902566E-4 OR13G1, OR2AK2, OR2L8, OR1C1, OR2L5, OR2T2, OR6F1, OR2T1, OR2T4, OR2T3, OR2L3, OR2L13, OR2L2, OR2G3, OR2G2, OR2T10, OR2T11, OR2G6, OR2T12, OR2T5, OR2T33, OR2T6, OR2T35, OR2T34, OR2T8, OR2C3, OR14C36, OR2M7, OR2B11, OR11L1, OR2W5, OR2M2, OR2W3, OR2M3, OR2AE1, OR2M4, OR2M5, OR14A16, OR2T29, OR2T27, OR14I1 1027 409 19235 1.8317172289503696 0.1682411784216591 0.08799187417088161 0.482313380413002 GOTERM_BP_FAT GO:0007608~sensory perception of smell 42 3.75 5.119480987958028E-4 OR13G1, OR2AK2, OR2L8, OR1C1, OR2L5, OR2T2, OR6F1, OR2T1, OR2T4, OR2T3, OR2L3, OR2L13, OR2L2, OR2G3, OR2G2, OR2T10, OR2T11, OR2G6, OR2T12, OR2T5, OR2T33, OR2T6, OR2T35, OR2T34, OR2T8, OR2C3, OR14C36, OR2M7, OR2B11, OR11L1, UBR3, OR2W5, OR2M2, OR2W3, OR2M3, OR2AE1, OR2M4, OR2M5, GNAL, OR14A16, OR2T29, OR2T27, OR14I1 751 431 13528 1.7553578986718406 0.7569195255586058 0.5069680796932168 0.9094378648920043 KEGG_PATHWAY hsa04740:Olfactory transduction 38 3.392857142857143 0.0013575796052678923 OR13G1, OR2AK2, OR2L8, OR1C1, OR2T2, OR6F1, OR2T1, OR2T4, OR2T3, OR2L3, OR2L13, OR2L2, OR2G3, OR2G2, OR2T10, OR2T11, OR2G6, OR2T12, OR2T33, OR2T5, OR2T6, OR2T34, OR2T8, OR2C3, OR14C36, OR2M7, OR2B11, OR11L1, OR2M2, OR2W3, OR2M3, OR2AE1, OR2M4, OR2M5, GNAL, OR14A16, OR2T29, OR2T27, OR14I1 301 379 5085 1.6938262081539985 0.19863264619619148 0.19863264619619148 1.6321130498466285 INTERPRO IPR000725:Olfactory receptor 40 3.571428571428571 0.0014592728227499484 OR13G1, OR2AK2, OR2L8, OR1C1, OR2L5, OR2T2, OR6F1, OR2T1, OR2T4, OR2T3, OR2L3, OR2L13, OR2L2, OR2G3, OR2G2, OR2T10, OR2T11, OR2G6, OR2T12, OR2T5, OR2T33, OR2T6, OR2T35, OR2T34, OR2T8, OR2C3, OR14C36, OR2M7, OR2B11, OR11L1, OR2W5, OR2M2, OR2W3, OR2M3, OR2AE1, OR2M4, OR2M5, OR14A16, OR2T29, OR2T27, OR14I1 920 428 16659 1.6922998780983338 0.8530149766795866 0.38081807306059545 2.359045167553442 GOTERM_MF_FAT GO:0004984~olfactory receptor activity 40 3.571428571428571 0.0019796465629076765 OR13G1, OR2AK2, OR2L8, OR1C1, OR2L5, OR2T2, OR6F1, OR2T1, OR2T4, OR2T3, OR2L3, OR2L13, OR2L2, OR2G3, OR2G2, OR2T10, OR2T11, OR2G6, OR2T12, OR2T5, OR2T33, OR2T6, OR2T35, OR2T34, OR2T8, OR2C3, OR14C36, OR2M7, OR2B11, OR11L1, OR2W5, OR2M2, OR2W3, OR2M3, OR2AE1, OR2M4, OR2M5, OR14A16, OR2T29, OR2T27, OR14I1 725 431 12983 1.6619569565565244 0.820585176080603 0.4359909044445507 3.0271440604129007 GOTERM_BP_FAT GO:0007606~sensory perception of chemical stimulus 42 3.75 0.0036018357469337755 OR13G1, OR2AK2, OR2L8, OR1C1, OR2L5, OR2T2, OR6F1, OR2T1, OR2T4, OR2T3, OR2L3, OR2L13, OR2L2, OR2G3, OR2G2, OR2T10, OR2T11, OR2G6, OR2T12, OR2T5, OR2T33, OR2T6, OR2T35, OR2T34, OR2T8, OR2C3, OR14C36, OR2M7, OR2B11, OR11L1, UBR3, OR2W5, OR2M2, OR2W3, OR2M3, OR2AE1, OR2M4, OR2M5, GNAL, OR14A16, OR2T29, OR2T27, OR14I1 751 478 13528 1.5827599462919733 0.9999530407093423 0.8100583288625076 6.234782839475561 SP_PIR_KEYWORDS sensory transduction 48 4.285714285714286 0.004673143696969792 OR2AK2, RP9, OR2T10, OR2T11, OR2T12, OR14C36, MYO3B, OR2W5, OR2AE1, OR2W3, OR14I1, OR13G1, OR2L8, OR2L5, BBS5, OR1C1, BBS7, OR6F1, OR2T2, OR2T1, BBS9, OR2T4, OR2T3, OR2L3, OR2L13, OR2L2, OR2G3, OR2G2, OR2G6, OR2T33, OR2T5, OR2T6, OR2T35, OR2T8, OR2T34, OR2C3, OR2M7, OR2B11, OR11L1, CYP4V2, OR2M2, OR2M3, KCNV2, OR2M4, OR2M5, OR14A16, OR2T29, OR2T27, ABCC6 1027 595 19235 1.5109358251577163 0.9263949773124309 0.2782888227025917 6.6184384130446805 GOTERM_BP_FAT GO:0050890~cognition 69 6.1607142857142865 0.0067266131989870345 GJA8, OR2AK2, RP9, CRYBB1, OR2T10, OR2T11, OR2T12, CHRNA7, OR14C36, GJD2, EGR1, RAX, MYO3B, UBR3, OR2W5, OR2W3, OR2AE1, MAPK1, GNAL, ALDH7A1, SLC26A5, PSEN2, OR14I1, CRYBA4, OR13G1, OR2L8, OR1C1, BBS5, OR2L5, OR6F1, OR2T2, BBS7, OR2T1, OR2T4, BBS9, OR2T3, ABI2, TAC1, COMT, OR2L3, GJC3, OR2L13, OR2L2, OR2G3, OR2G2, OR2G6, OR2T5, OR2T33, OR2T6, OR2T35, OR2T8, OR2T34, OR2C3, OR2M7, SLC12A2, HTT, OR2B11, OR11L1, TBX1, CYP4V2, OR2M2, KCNV2, OR2M3, OR2M4, OR2M5, OR14A16, OR2T29, OR2T27, VLDLR, ABCC6 751 909 13528 1.3673473872021022 0.9999999919827779 0.8449747674736383 11.344728620318934 GOTERM_BP_FAT GO:0007600~sensory perception 62 5.535714285714286 0.00864954538164717 GJA8, OR2AK2, RP9, CRYBB1, OR2T10, OR2T11, OR2T12, OR14C36, GJD2, RAX, MYO3B, UBR3, OR2W5, OR2W3, OR2AE1, MAPK1, GNAL, ALDH7A1, SLC26A5, OR14I1, CRYBA4, OR13G1, OR2L8, OR1C1, BBS5, OR2L5, OR6F1, OR2T2, BBS7, OR2T1, BBS9, OR2T4, OR2T3, TAC1, OR2L3, GJC3, OR2L13, OR2L2, OR2G3, OR2G2, OR2G6, OR2T5, OR2T33, OR2T6, OR2T35, OR2T8, OR2T34, OR2C3, OR2M7, SLC12A2, OR2B11, OR11L1, TBX1, CYP4V2, OR2M2, KCNV2, OR2M3, OR2M4, OR2M5, OR14A16, OR2T29, OR2T27, ABCC6 751 810 13528 1.378796994953231 0.99999999996202 0.8645966149603265 14.357408286932195 GOTERM_BP_FAT GO:0050877~neurological system process 86 7.678571428571429 0.01267110597853965 ALS2, OR2AK2, SEPT5, GJA8, GLRA3, RP9, MBP, CRYBB1, OR2T10, OR2T11, OR2T12, CHRNA7, CHRNA1, SLC1A1, OR14C36, GJD2, EGR1, RAX, MYO3B, PI4KA, UBR3, OR2W5, OR2W3, OR2AE1, MAPK1, GNAL, CHRM5, ALDH7A1, DOC2A, SLC26A5, PSEN2, NAB1, OR14I1, CRYBA4, OR13G1, OR2L8, OR1C1, BBS5, ACHE, OR2L5, SCN1A, OR6F1, OR2T2, BBS7, OR2T1, OR2T4, BBS9, OR2T3, ABI2, TAC1, AKAP9, COMT, OR2L3, GJC3, OR2L13, OR2L2, OR2G3, OR2G2, OR2G6, NPTX2, OR2T5, OR2T33, OR2T6, OR2T35, OR2T8, OR2T34, GAD1, OR2C3, OR2M7, DLGAP1, SLC12A2, HTT, OR2B11, OR11L1, TBX1, CYP4V2, OR2M2, AFG3L2, KCNV2, OR2M3, OR2M4, OR2M5, OR14A16, OR2T29, OR2T27, VLDLR, ABCC6 751 1210 13528 1.2802852395153568 0.9999999999999994 0.8740457039297361 20.348488289360557 GOTERM_BP_FAT GO:0007166~cell surface receptor linked signal transduction 124 11.071428571428571 0.017765662023321634 OR2AK2, QRFPR, BTRC, ITPKB, GALR1, BHLHA15, RAPGEF4, NPSR1, WNT6, OR14C36, WNT10A, GNB1L, PTPRT, MAPK1, VEGFC, MC2R, COL1A2, CSNK1G3, OR13G1, TWSG1, OR2L8, OR2L5, FGFR3, OR2T2, OR2T1, OR2T4, OR2T3, BMPR2, NPY6R, OR2L3, EPHB4, SRC, GPR141, OR2L13, ADCYAP1, OR2L2, ITGAV, FBXW4, OR2T5, OR2T33, OR2T6, OR2T35, OR2T8, OR2T34, OR2C3, OR2M7, ADAM29, PTPN2, HTT, MSTN, MALT1, OR2M2, OR2M3, OR2M4, OR2M5, GNGT1, OR14A16, EPHA4, SEMA6A, LAMA1, GPR35, OR2T29, ITGA6, OR2T27, CD274, SFRP4, ADM2, ADAM22, AP3S1, BUD31, OR2T10, OR2T11, VN1R5, OR2T12, MC5R, LBP, CALCRL, PILRB, BRD8, KIAA1324L, SLA2, OR2W5, INHA, OR2W3, OR2AE1, LEFTY1, GRP, GNAL, CHRM5, GNB2, GHRH, PSEN2, OR14I1, CALCR, OR1C1, OR6F1, COL3A1, TAC1, GNG11, OR2G3, OR2G2, OR2G6, GP1BB, DISP1, LEFTY2, TGM2, WDR12, SH2B2, SCG5, GIGYF1, WNT8A, BCL9, PTPRD, SLC12A2, OR2B11, OR11L1, FZD1, STAT1, FZD7, KREMEN1, MAPK8IP2, MC4R, JAK2, HPGD, IL2 751 1856 13528 1.2034758253363331 1.0 0.8946480034200059 27.37098983052595 SP_PIR_KEYWORDS transducer 61 5.446428571428571 0.026569028862392676 QRFPR, OR2AK2, OR2T10, GALR1, OR2T11, OR2T12, VN1R5, MC5R, NPSR1, CALCRL, OR14C36, OR2W5, OR2W3, OR2AE1, GNAL, CHRM5, GNB2, MC2R, OR14I1, CALCR, OR13G1, OR2L8, OR1C1, OR2L5, OR6F1, OR2T2, OR2T1, OR2T4, OR2T3, GNG11, NPY6R, OR2L3, OR2L13, GPR141, OR2L2, OR2G3, OR2G2, PLCL1, OR2G6, OR2T33, OR2T5, OR2T6, OR2T35, OR2T8, OR2T34, OR2C3, OR2M7, OR2B11, OR11L1, FZD1, OR2M2, OR2M3, OR2M4, FZD7, OR2M5, OR14A16, GNGT1, GPR35, OR2T29, PLCG1, OR2T27, MC4R 1027 874 19235 1.3071943119302851 0.9999996938219635 0.5458947445752682 32.54184174706174 SP_PIR_KEYWORDS cell membrane 135 12.053571428571429 0.05116905343083565 OR2AK2, QRFPR, CDIPT, MAEA, VAPA, ZAN, MEGF10, SEZ6L2, CDH20, GALR1, RAPGEF6, CHRNA7, NPSR1, CHRNA1, OR14C36, GJD2, SLC12A9, CTNNA1, PDCD1LG2, MC2R, SLC40A1, ADD1, OR13G1, OR2L8, OR2L5, ACHE, BBS5, BBS7, OR2T2, OR2T1, PANX2, BBS9, OR2T4, OR2T3, NOSTRIN, OR2L3, GPR141, OR2L13, OR2L2, PPP1R16B, RAC1, OR2T5, POTEC, OR2T33, OR2T6, GRID2IP, OR2T35, OR2T8, MFAP3L, OR2T34, OR2C3, EWSR1, OR2M7, PCDH10, OR2M2, OR2M3, SHANK3, DAGLB, OR2M4, OR2M5, ABCB4, GNGT1, OR14A16, GPR35, OR2T29, ITGA6, OR2T27, CDC42SE2, CD274, ECSCR, GJA8, STEAP4, GLRA3, CLDN5, GJA5, MBP, TMEM173, GPC2, OR2T10, OR2T11, MAPT, VN1R5, RASL10A, OR2T12, TICAM2, MC5R, CALCRL, GPC1, IHH, PILRA, RAB39B, SLA2, OR2W5, RFTN2, OR2W3, OR2AE1, ELMO1, FMN1, CHRM5, SLC26A5, DOK7, OR14I1, SLC27A6, SGCE, STEAP2, CALCR, OR1C1, OR6F1, TFR2, GNG11, COMT, CLDN12, GJC3, MYOT, CLDN15, NETO1, OR2G3, OR2G2, TMED7, OR2G6, SH2B2, RASA4, DLGAP1, CNST, NF2, OR2B11, OR11L1, RTN4R, CAPN2, KCNV2, RAPH1, RAB31, CDH19, MC4R, ABCC1, MUC17, GFRA3 1027 2194 19235 1.1524415086200392 0.9999999999998032 0.6228858623281609 53.599111604257054 SP_PIR_KEYWORDS g-protein coupled receptor 55 4.910714285714286 0.05878187588134154 OR2AK2, QRFPR, OR2T10, GALR1, OR2T11, VN1R5, OR2T12, MC5R, NPSR1, CALCRL, OR14C36, OR2W5, OR2W3, OR2AE1, CHRM5, MC2R, OR14I1, OR13G1, CALCR, OR2L8, OR1C1, OR2L5, OR2T2, OR6F1, OR2T1, OR2T4, OR2T3, NPY6R, OR2L3, OR2L13, GPR141, OR2L2, OR2G3, OR2G2, OR2G6, OR2T33, OR2T5, OR2T6, OR2T35, OR2T8, OR2T34, OR2C3, OR2M7, OR2B11, OR11L1, FZD1, OR2M2, OR2M3, OR2M4, FZD7, OR2M5, OR14A16, GPR35, OR2T29, OR2T27, MC4R 1027 816 19235 1.2623921282242205 0.9999999999999978 0.6403137466428723 58.754055205706294 PIR_SUPERFAMILY PIRSF800006:rhodopsin-like G protein-coupled receptors 47 4.196428571428571 0.059795159098344944 OR13G1, QRFPR, OR2AK2, OR2L8, OR1C1, OR2L5, OR2T2, OR6F1, OR2T1, OR2T4, OR2T3, OR2L3, OR2L13, GPR141, OR2L2, OR2G3, OR2G2, GALR1, OR2T10, OR2T11, OR2G6, OR2T12, OR2T5, OR2T33, MC5R, OR2T6, OR2T35, OR2T34, OR2T8, OR2C3, OR14C36, OR2M7, OR2B11, OR11L1, OR2M2, OR2W3, OR2M3, OR2AE1, OR2M4, OR2M5, OR14A16, GPR35, CHRM5, OR2T29, OR2T27, MC2R, MC4R, OR14I1 395 686 7396 1.2828431191644831 0.9999999999244736 0.9457046897599461 57.38313998272554 INTERPRO IPR000276:7TM GPCR, rhodopsin-like 51 4.553571428571428 0.06219088339300886 OR2AK2, QRFPR, GALR1, OR2T10, OR2T11, VN1R5, OR2T12, MC5R, NPSR1, OR14C36, OR2W5, OR2W3, OR2AE1, CHRM5, MC2R, OR14I1, OR13G1, OR2L8, OR2L5, OR1C1, OR2T2, OR6F1, OR2T1, OR2T4, OR2T3, NPY6R, OR2L3, OR2L13, GPR141, OR2L2, OR2G3, OR2G2, OR2G6, OR2T33, OR2T5, OR2T6, OR2T35, OR2T8, OR2T34, OR2C3, OR2M7, OR2B11, OR11L1, OR2M2, OR2M3, OR2M4, OR2M5, OR14A16, GPR35, OR2T29, OR2T27, MC4R 920 727 16659 1.2702724119370852 1.0 0.9907550606289579 64.9945469752357 SP_PIR_KEYWORDS receptor 99 8.839285714285715 0.0653867805237546 QRFPR, OR2AK2, TLR3, TLR5, SEZ6L2, GALR1, PGRMC2, CHRNA7, NPSR1, CHRNA1, OR14C36, PTPRM, PLXNB2, COLEC12, PTPRT, PTPRN, PDCD1LG2, RYR3, MC2R, CD226, OR13G1, OR2L8, OR2L5, FGFR3, OR2T2, OR2T1, OR2T4, OR2T3, BMPR2, NPY6R, OR2L3, EPHB4, GPR141, OR2L13, OR2L2, ITGAV, OR2T33, OR2T5, OR2T6, OR2T35, OR2T8, OR2T34, OR2C3, OR2M7, TRPC3, PTPN2, TRPC7, OR2M2, OR2M3, OR2M4, OR2M5, GNGT1, OR14A16, EPHA4, GPR35, OR2T29, P2RX6, ITGA6, OR2T27, CD274, ADAM22, GLRA3, DGCR2, TNFRSF11A, OR2T10, OR2T11, VN1R5, OR2T12, MC5R, CALCRL, LBR, PILRB, PILRA, FBXL18, KDELR2, OR2W5, NLRP3, OR2W3, OR2AE1, CHRM5, OR14I1, CALCR, OR1C1, OR6F1, TFR2, NETO1, SCARF2, OR2G3, OR2G2, OR2G6, PTPRD, OR2B11, OR11L1, FZD1, RTN4R, FZD7, MC4R, LRP2, VLDLR, GFRA3 1027 1583 19235 1.171321262119858 1.0 0.6590992343744109 62.78899350994318 GOTERM_BP_FAT GO:0007186~G-protein coupled receptor protein signaling pathway 75 6.696428571428571 0.06582773953736172 QRFPR, OR2AK2, BUD31, OR2T10, GALR1, BHLHA15, OR2T11, OR2T12, VN1R5, MC5R, RAPGEF4, CALCRL, NPSR1, OR14C36, KIAA1324L, GNB1L, OR2W5, OR2W3, OR2AE1, GRP, GNAL, CHRM5, GNB2, GHRH, MC2R, OR14I1, CALCR, OR13G1, OR2L8, OR1C1, OR2L5, OR6F1, OR2T2, OR2T1, OR2T4, OR2T3, TAC1, GNG11, NPY6R, OR2L3, OR2L13, GPR141, OR2L2, ADCYAP1, OR2G3, OR2G2, OR2G6, OR2T5, OR2T33, TGM2, OR2T6, OR2T35, SCG5, OR2T8, OR2T34, OR2C3, OR2M7, SLC12A2, HTT, OR2B11, OR11L1, FZD1, OR2M2, OR2M3, OR2M4, FZD7, OR2M5, OR14A16, GNGT1, GPR35, OR2T29, OR2T27, MC4R, ADM2, JAK2, IL2 751 1123 13528 1.203026418915474 1.0 0.9652130966904792 70.32514083698118 INTERPRO IPR017452:GPCR, rhodopsin-like superfamily 50 4.464285714285714 0.0817263671194967 OR2AK2, QRFPR, GALR1, OR2T10, OR2T11, OR2T12, MC5R, NPSR1, OR14C36, OR2W5, OR2W3, OR2AE1, CHRM5, MC2R, OR14I1, OR13G1, OR2L8, OR2L5, OR1C1, OR2T2, OR6F1, OR2T1, OR2T4, OR2T3, NPY6R, OR2L3, OR2L13, GPR141, OR2L2, OR2G3, OR2G2, OR2G6, OR2T33, OR2T5, OR2T6, OR2T35, OR2T8, OR2T34, OR2C3, OR2M7, OR2B11, OR11L1, OR2M2, OR2M3, OR2M4, OR2M5, OR14A16, GPR35, OR2T29, OR2T27, MC4R 920 726 16659 1.2470804886812792 1.0 0.9923053176460259 75.18697943771919 UP_SEQ_FEATURE topological domain:Extracellular 142 12.678571428571427 0.67548348606768 OR2AK2, QRFPR, FAM200A, ZAN, TLR5, MEGF10, SEZ6L2, CDH20, FAM171B, GALR1, PRRT2, CHRNA7, NPSR1, CHRNA1, MUC12, OR14C36, GJD2, TMEFF2, SLC12A9, PTPRM, ABCB11, PLXNB2, COLEC12, C1ORF101, PTPRT, PTPRN, PDCD1LG2, PKD2L2, ATP9B, UPK3BL, MC2R, CD226, OR13G1, OR2L8, ERMP1, OR2L5, FGFR3, OR2T2, OR2T1, PANX2, OR2T4, OR2T3, BMPR2, SLC38A11, NPY6R, OR2L3, EPHB4, OR2L13, GPR141, OR2L2, TMEM129, MIA3, ITGAV, OR2T5, OR2T33, OR2T6, OR2T35, OR2T8, MFAP3L, OR2T34, OR2C3, OR2M7, ADAM29, NOMO3, TRPC3, PCDH10, TRPC7, OR2M2, OR2M3, OR2M4, DAGLB, OR2M5, ABCB4, OR14A16, EPHA4, SEMA6A, GPR35, OR2T29, P2RX6, ITGA6, OR2T27, CD274, ECSCR, ADAM22, GJA8, GLRA3, CLDN5, APCDD1, GJA5, TMEM173, DGCR2, TNFRSF11A, SLC23A3, OR2T10, OR2T11, VN1R5, OR2T12, ATP8B1, MC5R, CALCRL, SLC1A1, PILRB, PILRA, KIAA1324L, HEPACAM2, OR2W3, OR2AE1, CHRM5, SLC26A5, OR14I1, SGCE, SUSD4, CALCR, OR1C1, MFSD8, OR6F1, TFR2, CLDN12, GJC3, NETO1, CLDN15, SCARF2, OR2G3, OR2G2, GPM6A, OR2G6, GP1BB, LRRTM2, PTPRD, OR2B11, OR11L1, FZD1, GDPD3, FZD7, CDH19, KREMEN1, MC4R, ABCC1, LRP2, SP9, MUC17, ABCC6, VLDLR 1024 2719 19113 0.9747832095899228 1.0 0.9999999909709376 99.99999977853439 Annotation Cluster 4 Enrichment Score: 1.8669254099952537 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0031674~I band 10 0.8928571428571428 0.0031103730415758275 SRI, ALDOA, ACTC1, DES, SORBS2, PSEN2, PDLIM3, OBSL1, MYOZ2, MYOT 713 55 12782 3.259467040673212 0.7779052991383363 0.7779052991383363 4.366043965467714 GOTERM_CC_FAT GO:0044449~contractile fiber part 14 1.25 0.01003137810653694 ALDOA, SRI, ACTC1, PDLIM3, MYOZ2, LMAN1, MYOT, MYL9, DES, SORBS2, PSEN2, MYH11, OBSL1, MYOM1 713 113 12782 2.221052762228649 0.9923237272791423 0.5012549160111905 13.452706704678906 GOTERM_CC_FAT GO:0030018~Z disc 8 0.7142857142857143 0.012969051504208155 SRI, DES, SORBS2, PSEN2, PDLIM3, OBSL1, MYOZ2, MYOT 713 46 12782 3.117751082383072 0.9981729012101141 0.5453049212853432 17.06117562921795 GOTERM_CC_FAT GO:0043292~contractile fiber 14 1.25 0.017136137758820398 ALDOA, SRI, ACTC1, PDLIM3, MYOZ2, LMAN1, MYOT, MYL9, DES, SORBS2, PSEN2, MYH11, OBSL1, MYOM1 713 121 12782 2.0742062986102257 0.9997632465008459 0.5660600439661085 21.94023807570534 GOTERM_CC_FAT GO:0030017~sarcomere 12 1.0714285714285714 0.020193412141096927 SRI, ALDOA, ACTC1, DES, SORBS2, PSEN2, PDLIM3, OBSL1, MYOZ2, MYOM1, LMAN1, MYOT 713 98 12782 2.195151272290122 0.9999474235153175 0.5313699657296378 25.348581191532602 GOTERM_CC_FAT GO:0030016~myofibril 12 1.0714285714285714 0.04489971575194167 SRI, ALDOA, ACTC1, DES, SORBS2, PSEN2, PDLIM3, OBSL1, MYOZ2, MYOM1, LMAN1, MYOT 713 111 12782 1.9380614836435313 0.9999999997689774 0.6189092033938549 48.22804757412001 Annotation Cluster 5 Enrichment Score: 1.7262048793862523 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007010~cytoskeleton organization 41 3.660714285714286 0.001213594222475706 ALDOA, HAUS3, MAEA, CEP120, PDLIM3, ABI2, ANLN, CETN1, SPC25, TUBGCP6, NDE1, DES, SEH1L, MAPT, BCL2, RAC1, GRID2IP, NEFH, OBSL1, RANBP1, SH2B2, WIPF1, PPP4C, ACTC1, TAOK2, NF2, PCNT, FSCN1, NDC80, TACC3, ELMO1, ARPC1A, FMN1, EPB41L3, SEMA6A, PPP1R9A, EPB41L1, CAPN10, XIRP2, MYH11, ADD1 751 436 13528 1.6939127035512282 0.9650551034168728 0.673065122891541 2.143183937655535 GOTERM_CC_FAT GO:0015629~actin cytoskeleton 27 2.410714285714286 0.004392590706236328 ALDOA, MAEA, STK17B, PDLIM3, ANLN, MYOT, MYL9, SORBS2, SH2B2, WIPF1, MYOM1, ACTC1, MYO1B, FSCN1, MYO3B, MYL12B, MYOZ2, MYL12A, CTNNA1, ARPC1A, FMN1, ARPC1B, PPP1R9A, MYH11, SEPT7, DYNC1I2, ADD1 713 269 12782 1.7993712101857693 0.8807215625796029 0.4123205760826779 6.113734731579812 GOTERM_BP_FAT GO:0030036~actin cytoskeleton organization 23 2.0535714285714284 0.0073246520948180936 ALDOA, ACTC1, NF2, TAOK2, FSCN1, PDLIM3, ABI2, ELMO1, FMN1, ARPC1A, EPB41L3, PPP1R9A, EPB41L1, CAPN10, XIRP2, BCL2, RAC1, MYH11, OBSL1, GRID2IP, SH2B2, WIPF1, ADD1 751 226 13528 1.8332135323992786 0.9999999984808946 0.8421203437528901 12.292236966510295 GOTERM_BP_FAT GO:0030029~actin filament-based process 23 2.0535714285714284 0.014846278201379159 ALDOA, ACTC1, NF2, TAOK2, FSCN1, PDLIM3, ABI2, ELMO1, FMN1, ARPC1A, EPB41L3, PPP1R9A, EPB41L1, CAPN10, XIRP2, BCL2, RAC1, MYH11, OBSL1, GRID2IP, SH2B2, WIPF1, ADD1 751 241 13528 1.719113105071523 1.0 0.8992545928024377 23.421799169367063 GOTERM_BP_FAT GO:0007015~actin filament organization 10 0.8928571428571428 0.017577471524449714 ALDOA, PPP1R9A, ACTC1, BCL2, FSCN1, RAC1, PDLIM3, ABI2, WIPF1, ADD1 751 72 13528 2.5018493860038467 1.0 0.9029389957253906 27.1223264956723 SP_PIR_KEYWORDS actin-binding 20 1.7857142857142856 0.0695634914015843 ENAH, MAEA, BAIAP2L1, MYO1B, FSCN1, MYO3B, SPIRE1, ANLN, KLHL3, MYOT, FMN1, ARPC1A, EPB41L3, ARPC1B, PPP1R9A, EPB41L1, XIRP2, MYH11, WIPF1, ADD1 1027 247 19235 1.5165432118232816 1.0 0.6622397511392009 65.14740617903954 GOTERM_MF_FAT GO:0008092~cytoskeletal protein binding 37 3.303571428571429 0.07669093202380727 ALDOA, ENAH, MAEA, PDLIM3, ABI2, ANLN, KLHL3, MYOT, TUBGCP6, NDE1, SORBS2, MAPT, OBSL1, GRID2IP, WIPF1, ACTC1, NF2, HTT, BAIAP2L1, MYO1B, FSCN1, MYO3B, SPIRE1, PTPRT, CTNNA1, CAPN2, ARPC1A, FMN1, EPB41L3, ARPC1B, PPP1R9A, EPB41L1, CAPN10, XIRP2, MAPK8IP2, MYH11, ADD1 725 504 12983 1.3146442255062947 1.0 0.9569115623125648 70.99600793551798 GOTERM_MF_FAT GO:0003779~actin binding 22 1.9642857142857142 0.2851545727728541 ALDOA, ENAH, MAEA, MYO1B, BAIAP2L1, FSCN1, MYO3B, SPIRE1, ANLN, KLHL3, MYOT, FMN1, ARPC1A, EPB41L3, ARPC1B, PPP1R9A, EPB41L1, XIRP2, MYH11, GRID2IP, WIPF1, ADD1 725 326 12983 1.2084874127353502 1.0 0.9908520996608157 99.45233923505187 Annotation Cluster 6 Enrichment Score: 1.5817537540506468 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS endoplasmic reticulum 53 4.732142857142857 0.013852497688616152 CYP3A4, CYP3A5, CDIPT, CYP3A7, SEC31A, ORMDL1, TLR3, CYP3A43, SEZ6L2, TMEM173, P4HA2, XYLT1, RESP18, PLOD3, AGPAT9, TICAM2, SCD5, RPN2, MLANA, KDELR2, PGAP1, DHRS9, CYB5A, LPIN2, LPCAT4, PIGN, LRPAP1, PSEN2, SIL1, KDSR, DEGS1, FKBP9, ERMP1, CRELD2, CYP51A1, LMF2, TMX3, BET1, LMAN1, G6PC2, FMO5, TMED7, MIA3, BCL2, ACSL6, MOGAT3, NOMO3, SEC11C, ARMC10, EPHX1, CYP4V2, SDF2L1, SPCS3, ALG12 1027 713 19235 1.3922207002790028 0.9995776945831658 0.4499111787992546 18.447546981034346 GOTERM_CC_FAT GO:0005789~endoplasmic reticulum membrane 25 2.232142857142857 0.015432271122457868 CYP3A4, CYP3A5, CYP3A7, VAPA, CYP51A1, ORMDL1, RP9, LMAN1, FMO5, MIA3, BCL2, AGPAT9, RPN2, MLANA, NOMO3, SEC11C, PGAP1, DHRS9, PIGN, RYR3, SPCS3, ASPHD1, KDSR, ALG12, SRP9 713 269 12782 1.6660844538757125 0.9994534583472173 0.5659760489027739 19.978452616164677 GOTERM_CC_FAT GO:0042175~nuclear envelope-endoplasmic reticulum network 25 2.232142857142857 0.027689411733799178 CYP3A4, CYP3A5, CYP3A7, VAPA, CYP51A1, ORMDL1, RP9, LMAN1, FMO5, MIA3, BCL2, AGPAT9, RPN2, MLANA, NOMO3, SEC11C, PGAP1, DHRS9, PIGN, RYR3, SPCS3, ASPHD1, KDSR, ALG12, SRP9 713 284 12782 1.5780870355372063 0.999998712277391 0.5951245086663282 33.12844372858418 GOTERM_CC_FAT GO:0005783~endoplasmic reticulum 68 6.071428571428571 0.03088739933440468 CYP3A4, CYP3A5, CDIPT, CYP3A7, SEC31A, VAPA, ORMDL1, TLR3, RP9, FAM57B, CYP3A43, SEZ6L2, TMEM173, GPC2, P4HA2, XYLT1, RESP18, EMID1, PLOD3, AGPAT9, TICAM2, RPN2, SCD5, MLANA, KDELR2, AIFM3, PGAP1, DHRS9, CYB5A, LPCAT4, LRPAP1, PIGN, RYR3, PSEN2, ASPHD1, SIL1, KDSR, SRP9, DEGS1, TPST2, FKBP9, ERMP1, CRELD2, NAPG, CYP51A1, LMF2, TMX3, BET1, LMAN1, G6PC2, TMED7, FMO5, KIAA0020, MIA3, BCL2, ACSL6, MOGAT3, NOMO3, SEC11C, ARMC10, RTN4R, EPHX1, CRIPAK, CYP4V2, CNIH4, SDF2L1, SPCS3, LRP2, ALG12 713 960 12782 1.2698340345956054 0.9999997377242583 0.589920438044679 36.21215827362555 GOTERM_CC_FAT GO:0044432~endoplasmic reticulum part 29 2.5892857142857144 0.031281194058783726 CYP3A4, CYP3A5, CYP3A7, VAPA, CYP51A1, ORMDL1, RP9, LMAN1, FMO5, MIA3, P4HA2, BCL2, AGPAT9, RPN2, MLANA, NOMO3, SEC11C, PGAP1, DHRS9, PIGN, LRPAP1, RYR3, SDF2L1, SPCS3, ASPHD1, SIL1, KDSR, ALG12, SRP9 713 347 12782 1.4982276454967645 0.9999997844718459 0.5737748113704829 36.5825957527392 GOTERM_CC_FAT GO:0012505~endomembrane system 55 4.910714285714286 0.05651206147926305 CYP3A4, CYP3A5, CYP3A7, SEC31A, AP1B1, VAPA, ORMDL1, RP9, VGF, AP1S1, SEH1L, AGPAT9, RPN2, LBR, MLANA, PGAP1, DHRS9, AP4M1, PIGN, MAD2L1, CHSY3, CHPF, RYR3, ASPHD1, KDSR, CUX1, STEAP2, MATR3, SRP9, MVP, THAP7, CLCN3, LMNB1, CYP51A1, BET1, AHCTF1, LMAN1, SLC32A1, FMO5, SUMO1, MIA3, GP1BB, BCL2, GAD1, NOMO3, SEC11C, ABCB4, ZG16, SPCS3, HSPD1, LRP2, PARP1, ALG12, CLTCL1, VLDLR 713 782 12782 1.260855217140213 0.9999999999993724 0.6606255331654445 56.55270520664997 Annotation Cluster 7 Enrichment Score: 1.5643598909849645 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0021988~olfactory lobe development 4 0.35714285714285715 0.011083720796189078 SALL3, DLX2, HTT, RAC1 751 9 13528 8.005918035212309 0.9999999999999573 0.8715578943564216 18.032574646496947 GOTERM_BP_FAT GO:0021537~telencephalon development 9 0.8035714285714285 0.02658647776021148 SALL3, DLX2, NDE1, DLX1, CEP120, HTT, RAC1, RELN, TACC3 751 65 13528 2.4941513878930657 1.0 0.9364866816705901 38.167910814044525 GOTERM_BP_FAT GO:0021772~olfactory bulb development 3 0.26785714285714285 0.06879770406522681 SALL3, DLX2, RAC1 751 8 13528 6.754993342210386 1.0 0.9644498661223166 71.9640108276302 Annotation Cluster 8 Enrichment Score: 1.5585146333299256 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002520~immune system development 29 2.5892857142857144 0.0014943322460055767 CALCR, CSF2, TWSG1, MAEA, ITPKB, CTNNBL1, TNFRSF11A, BCL2, CASP8, PMS2, PMS2CL, EPO, EGR1, EXO1, POLL, CDK6, MALT1, TBX1, INHA, TACC3, CRKL, SP3, PSEN2, JAK2, HSPD1, SCAND1, NHEJ1, IL2, ADD1 751 276 13528 1.8927034485420404 0.9839240763533889 0.6439229496507825 2.6327489333431098 GOTERM_BP_FAT GO:0048534~hemopoietic or lymphoid organ development 23 2.0535714285714284 0.03272987563662524 EGR1, CALCR, CSF2, TWSG1, MAEA, CDK6, MALT1, ITPKB, TBX1, INHA, TACC3, TNFRSF11A, CRKL, SP3, BCL2, PSEN2, CASP8, JAK2, SCAND1, NHEJ1, ADD1, IL2, EPO 751 260 13528 1.593485608931681 1.0 0.9624689126155985 44.772116711412544 GOTERM_BP_FAT GO:0030099~myeloid cell differentiation 11 0.9821428571428571 0.03294006476363843 CALCR, CSF2, MAEA, SP3, PSEN2, CASP8, JAK2, INHA, SCAND1, ADD1, EPO 751 93 13528 2.130607219048437 1.0 0.9588318925735395 44.98583645320371 GOTERM_BP_FAT GO:0002573~myeloid leukocyte differentiation 6 0.5357142857142857 0.03787977885246975 CALCR, CSF2, SP3, PSEN2, CASP8, SCAND1 751 34 13528 3.1788203963342996 1.0 0.9525150989847984 49.7894072372416 GOTERM_BP_FAT GO:0030097~hemopoiesis 20 1.7857142857142856 0.06579968037046795 EGR1, CALCR, CSF2, TWSG1, MAEA, CDK6, MALT1, ITPKB, INHA, TACC3, SP3, BCL2, PSEN2, CASP8, JAK2, SCAND1, NHEJ1, ADD1, IL2, EPO 751 236 13528 1.5265521677311609 1.0 0.9672243642029877 70.309234705546 GOTERM_BP_FAT GO:0002521~leukocyte differentiation 12 1.0714285714285714 0.11095963237858428 CALCR, EGR1, CSF2, BCL2, SP3, PSEN2, CASP8, MALT1, ITPKB, SCAND1, NHEJ1, IL2 751 131 13528 1.6500747095475752 1.0 0.9672690005819427 87.73379774724404 Annotation Cluster 9 Enrichment Score: 1.357150202309992 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005070~SH3/SH2 adaptor activity 8 0.7142857142857143 0.018142750887688623 CRKL, TP53BP2, SLA2, CHN1, ABI2, SH2B2, SRC, SH3BP2 725 49 12983 2.9236875439831103 0.9999998723795638 0.9290443955362189 24.724692411893457 SP_PIR_KEYWORDS SH2 domain 12 1.0714285714285714 0.03470526947487793 STAT4, CRKL, PLCG1, SLA2, SOCS6, CHN1, SH2B2, JAK2, YES1, STAT1, SRC, SH3BP2 1027 111 19235 2.0247901260559487 0.9999999971451452 0.5910996750257584 40.33146650042069 INTERPRO IPR000980:SH2 motif 12 1.0714285714285714 0.042525435201055097 STAT4, CRKL, PLCG1, SLA2, SOCS6, CHN1, SH2B2, JAK2, YES1, STAT1, SRC, SH3BP2 920 111 16659 1.9575793184488834 1.0 0.983017357482073 50.855594940500936 SMART SM00252:SH2 12 1.0714285714285714 0.04800407071235503 STAT4, CRKL, PLCG1, SLA2, SOCS6, CHN1, SH2B2, JAK2, YES1, STAT1, SRC, SH3BP2 513 111 9079 1.913281702755387 0.9999984556531426 0.9884411414390634 47.66777242247829 UP_SEQ_FEATURE domain:SH2 10 0.8928571428571428 0.07143516959309486 STAT4, CRKL, SLA2, SOCS6, CHN1, SH2B2, YES1, STAT1, SRC, SH3BP2 1024 96 19113 1.9442749023437502 1.0 0.9999936660409817 73.08214907311199 GOTERM_MF_FAT GO:0030674~protein binding, bridging 10 0.8928571428571428 0.07837206933403552 CRKL, TP53BP2, SLA2, FSCN1, COL1A2, CHN1, ABI2, SH2B2, SRC, SH3BP2 725 94 12983 1.9050623624358034 1.0 0.9475709415453452 71.80446744124849 Annotation Cluster 10 Enrichment Score: 1.3557143973965422 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006826~iron ion transport 6 0.5357142857142857 0.02025897602962927 FTMT, STEAP4, TFR2, STEAP2, STEAP1, SLC40A1 751 29 13528 3.7268928784609026 1.0 0.9051454853166 30.59081759405239 GOTERM_BP_FAT GO:0055072~iron ion homeostasis 6 0.5357142857142857 0.04691848013978986 SRI, FTMT, HTT, TFR2, ABCB6, SLC40A1 751 36 13528 3.002219263204616 1.0 0.9607284615033269 57.57127237634894 GOTERM_BP_FAT GO:0006879~cellular iron ion homeostasis 5 0.4464285714285714 0.09013539824861948 SRI, FTMT, TFR2, ABCB6, SLC40A1 751 31 13528 2.905373480520596 1.0 0.9647339453027349 81.460153728269 Annotation Cluster 11 Enrichment Score: 1.343437446712638 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR004825:Insulin/IGF/relaxin 4 0.35714285714285715 0.014993865730532147 INSL4, RLN1, RLN2, INSL6 920 10 16659 7.243043478260869 0.999999997571591 0.9162152014917604 21.883684389485968 SMART SM00078:IlGF 4 0.35714285714285715 0.015885165921926195 INSL4, RLN1, RLN2, INSL6 513 10 9079 7.079142300194932 0.9871633508410254 0.8867010628515223 19.004644064603138 UP_SEQ_FEATURE propeptide:Connecting peptide 3 0.26785714285714285 0.03717273472930775 RLN1, RLN2, INSL6 1024 6 19113 9.33251953125 1.0 0.9999991547172156 48.86883897113757 GOTERM_MF_FAT GO:0005179~hormone activity 11 0.9821428571428571 0.07869030621423351 GRP, INSL4, RLN1, GHRH, RLN2, ADM2, INHA, INSL6, VGF, ADCYAP1, EPO 725 108 12983 1.823920817369093 1.0 0.9417108636923535 71.95511440618594 SP_PIR_KEYWORDS hormone 9 0.8035714285714285 0.09237389564694143 INSL4, RLN1, GHRH, RLN2, ADM2, INHA, INSL6, ADCYAP1, EPO 1027 87 19235 1.9375146895880202 1.0 0.6987119336963157 75.75361670131275 SP_PIR_KEYWORDS cleavage on pair of basic residues 20 1.7857142857142856 0.13513720729715847 INSL4, ADAMTS19, TAC1, MSTN, INHA, INSL6, ADCYAP1, GRP, VEGFC, CDH20, ITGA6, RLN1, RESP18, GHRH, ITGAV, CDH19, RLN2, ADM2, SCG5, ADAM22 1027 271 19235 1.3822368019201128 1.0 0.7401875446181394 88.02601842484673 Annotation Cluster 12 Enrichment Score: 1.3266136063262544 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0021537~telencephalon development 9 0.8035714285714285 0.02658647776021148 SALL3, DLX2, NDE1, DLX1, CEP120, HTT, RAC1, RELN, TACC3 751 65 13528 2.4941513878930657 1.0 0.9364866816705901 38.167910814044525 GOTERM_BP_FAT GO:0021543~pallium development 7 0.625 0.04032181445334017 DLX2, NDE1, DLX1, CEP120, RAC1, RELN, TACC3 751 46 13528 2.741156718578128 1.0 0.9536871071932321 52.01517312422237 GOTERM_BP_FAT GO:0030900~forebrain development 15 1.3392857142857142 0.04277583250390177 TWSG1, RAX, CEP120, HTT, TACC3, SRC, SALL3, DLX2, DLX1, NDE1, GHRH, PSEN2, RAC1, RELN, LRP2 751 152 13528 1.77762982689747 1.0 0.9547751323203946 54.157810352312254 GOTERM_BP_FAT GO:0021987~cerebral cortex development 5 0.4464285714285714 0.10768277343791284 NDE1, CEP120, RAC1, RELN, TACC3 751 33 13528 2.7292902392769234 1.0 0.9673033957101151 86.90165742929717 Annotation Cluster 13 Enrichment Score: 1.3146037497863055 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006457~protein folding 18 1.607142857142857 0.019210069213734738 FKBP9, PPIL2, VBP1, LMAN1, LRPAP1, DNAJC18, PPIG, TXNDC2, PPIC, HSPA4L, PPIL3, SIL1, DNAJB2, HSPE1, HSPD1, DNAJC2, ALG12, HSPA9 751 177 13528 1.8318626012773929 1.0 0.9026384894711138 29.25305081234164 GOTERM_MF_FAT GO:0051082~unfolded protein binding 13 1.1607142857142858 0.02654439142982118 VBP1, AFG3L2, LMAN1, LRPAP1, DNAJC18, PPIC, SIL1, SCG5, HSPE1, DNAJB2, HSPD1, DNAJC2, HSPA9 725 115 12983 2.024335832083958 0.9999999999258513 0.9251044624009015 34.11933574561422 SP_PIR_KEYWORDS Chaperone 12 1.0714285714285714 0.22319632939735667 DNAJC18, PSMG2, HSPA4L, VBP1, DNAJB2, HSPE1, SCG5, HSPD1, DNAJC2, CDC37L1, SCO2, HSPA9 1027 158 19235 1.4224791391912046 1.0 0.827697249257024 97.50843003694143 Annotation Cluster 14 Enrichment Score: 1.271598955327771 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016445~somatic diversification of immunoglobulins 6 0.5357142857142857 0.006181900258283137 POLL, EXO1, PMS2, PMS2CL, HSPD1, CTNNBL1 751 22 13528 4.912722430698462 0.9999999635528721 0.8508860943138912 10.473306919661173 GOTERM_BP_FAT GO:0016446~somatic hypermutation of immunoglobulin genes 4 0.35714285714285715 0.011083720796189078 POLL, EXO1, PMS2, PMS2CL 751 9 13528 8.005918035212309 0.9999999999999573 0.8715578943564216 18.032574646496947 GOTERM_BP_FAT GO:0002566~somatic diversification of immune receptors via somatic mutation 4 0.35714285714285715 0.011083720796189078 POLL, EXO1, PMS2, PMS2CL 751 9 13528 8.005918035212309 0.9999999999999573 0.8715578943564216 18.032574646496947 GOTERM_BP_FAT GO:0002200~somatic diversification of immune receptors 6 0.5357142857142857 0.01508150523780703 POLL, EXO1, PMS2, PMS2CL, HSPD1, CTNNBL1 751 27 13528 4.002959017606155 1.0 0.8901978183731829 23.74736115198597 GOTERM_BP_FAT GO:0002377~immunoglobulin production 6 0.5357142857142857 0.023234219915688265 POLL, EXO1, PMS2, PMS2CL, HSPD1, CTNNBL1 751 30 13528 3.6026631158455396 1.0 0.9255186759547263 34.256689741334334 GOTERM_BP_FAT GO:0002440~production of molecular mediator of immune response 6 0.5357142857142857 0.026477716268794065 POLL, EXO1, PMS2, PMS2CL, HSPD1, CTNNBL1 751 31 13528 3.4864481766247155 1.0 0.9421936349309066 38.044538247658075 GOTERM_BP_FAT GO:0006298~mismatch repair 5 0.4464285714285714 0.04686664718811671 EXO1, PMS2, ZNF12, PMS2CL, PMS1 751 25 13528 3.6026631158455396 1.0 0.9636452882068104 57.5300860511725 GOTERM_BP_FAT GO:0016447~somatic recombination of immunoglobulin gene segments 4 0.35714285714285715 0.0744267744773043 EXO1, PMS2, PMS2CL, HSPD1 751 18 13528 4.0029590176061545 1.0 0.9681099967953578 74.83852576136626 GOTERM_BP_FAT GO:0016444~somatic cell DNA recombination 4 0.35714285714285715 0.14521793225697405 EXO1, PMS2, PMS2CL, HSPD1 751 24 13528 3.002219263204616 1.0 0.9776648994000899 93.9153601112244 GOTERM_BP_FAT GO:0002562~somatic diversification of immune receptors via germline recombination within a single locus 4 0.35714285714285715 0.14521793225697405 EXO1, PMS2, PMS2CL, HSPD1 751 24 13528 3.002219263204616 1.0 0.9776648994000899 93.9153601112244 GOTERM_BP_FAT GO:0002252~immune effector process 11 0.9821428571428571 0.2094597331328188 POLL, EXO1, BCL2, SLA2, SAMHD1, PMS2, LBP, PMS2CL, HSPD1, NLRP3, CTNNBL1 751 134 13528 1.4787050102351096 1.0 0.9831410441731622 98.4903858081283 GOTERM_MF_FAT GO:0043566~structure-specific DNA binding 11 0.9821428571428571 0.29002574771161554 EXO1, EGR1, HMGB2, MCM7, SP3, PMS2, ZNF12, PMS2CL, HSPD1, PMS1, FEV 725 145 12983 1.3585065398335316 1.0 0.9910295379139573 99.50745319827065 GOTERM_BP_FAT GO:0006310~DNA recombination 4 0.35714285714285715 0.9356134193962355 EXO1, PMS2, PMS2CL, HSPD1 751 105 13528 0.6862215458753408 1.0 0.9999875057392845 100.0 Annotation Cluster 15 Enrichment Score: 1.2634593496614885 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE metal ion-binding site:Iron (heme axial ligand) 13 1.1607142857142858 0.006041697109028472 CYP3A4, CYP3A5, STEAP4, CYP3A7, CYP51A1, CYB5A, CYP20A1, CYP4V2, CYP3A43, DGCR8, CYBRD1, STEAP2, STEAP1 1024 98 19113 2.4759745695153064 0.9999998417511221 0.994591042782367 10.17499883948595 SP_PIR_KEYWORDS iron 26 2.3214285714285716 0.010200034312526068 CYP3A4, FTMT, STEAP4, CYP3A5, CYP3A7, CYP51A1, CYP3A43, P4HA2, DGCR8, PLOD3, MIOX, KDM3B, SCD5, PPP4C, AIFM3, CYB5A, CYP20A1, CYP4V2, CDO1, NDUFV2, AOX1, CYBRD1, KDM4C, STEAP2, STEAP1, SLC40A1 1027 285 19235 1.708638685320897 0.9966892912865032 0.37866367032172443 13.918771363512072 GOTERM_MF_FAT GO:0005506~iron ion binding 27 2.410714285714286 0.02355330007703102 CYP3A4, FTMT, STEAP4, CYP3A5, CYP3A7, CYP51A1, CYP3A43, P4HA2, PLOD3, PGRMC2, MIOX, KDM3B, SCD5, PPP4C, AIFM3, CYB5A, CYP20A1, CYP4V2, CDO1, EIF2AK1, NDUFV2, AOX1, CYBRD1, KDM4C, STEAP2, STEAP1, SLC40A1 725 308 12983 1.569820868786386 0.9999999989400488 0.9477726506217244 30.90823993427151 SP_PIR_KEYWORDS oxidoreductase 38 3.392857142857143 0.10927177889643555 NDUFB3, CYP3A4, STEAP4, FTMT, CYP3A5, CYP3A7, CYP51A1, GLDC, CYP3A43, FMO5, P4HA2, PLOD3, MIOX, SCD5, LOX, HSD17B4, KDM3B, CTBP1, AIFM3, DHRS9, CYP4V2, CYP20A1, CDO1, SCCPDH, PYCR2, ALDH7A1, NDUFV2, AOX1, CYBRD1, ASPHD1, KDM4C, TXNRD2, KDSR, STEAP2, HPGD, STEAP1, PMPCB, DEGS1 1027 562 19235 1.2663945361364164 1.0 0.7462375819393936 81.57824285788556 GOTERM_MF_FAT GO:0009055~electron carrier activity 18 1.607142857142857 0.11157276976244157 CYP3A4, STEAP4, CYP3A5, CYP3A7, AIFM3, CYP51A1, CYP20A1, CYP4V2, GLDC, CYP3A43, FMO5, P4HA2, NDUFV2, AOX1, TXNRD2, STEAP2, STEAP1, DEGS1 725 221 12983 1.4585364331408956 1.0 0.9510381904739498 84.04074014603633 GOTERM_BP_FAT GO:0055114~oxidation reduction 41 3.660714285714286 0.23640598884795258 NDUFB3, CYP3A4, STEAP4, FTMT, CYP3A5, CYP3A7, CYP51A1, GLDC, CYP3A43, FMO5, P4HA2, PLOD3, MIOX, SCD5, LOX, HSD17B4, KDM3B, SCO2, CTBP1, AIFM3, F8, DHRS9, CYB5A, CYP4V2, CYP20A1, CDO1, SLC25A12, SCCPDH, PYCR2, ALDH7A1, NDUFV2, AOX1, CYBRD1, ASPHD1, KDM4C, TXNRD2, KDSR, STEAP2, HPGD, STEAP1, DEGS1 751 639 13528 1.1557839417031854 1.0 0.9817790379442762 99.18687999538241 SP_PIR_KEYWORDS metalloprotein 9 0.8035714285714285 0.34217439155383633 CYP3A43, CYP3A4, CYP3A5, CYP3A7, CYP51A1, NDUFV2, AOX1, CYB5A, PPP4C 1027 124 19235 1.359385306404498 1.0 0.8800558387944747 99.78072839133756 Annotation Cluster 16 Enrichment Score: 1.198347014801102 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS microsome 12 1.0714285714285714 0.025831007969312314 CYP3A43, CYP3A4, FMO5, CYP3A5, CYP3A7, SEC11C, CYP51A1, SPCS3, DHRS9, EPHX1, CYB5A, ACSL6 1027 106 19235 2.120299094266135 0.9999995330115976 0.5550668307950384 31.790295514135035 GOTERM_CC_FAT GO:0042598~vesicular fraction 20 1.7857142857142856 0.08742074681985515 ALS2, CYP3A4, CPT1B, CYP3A5, CYP3A7, SEC11C, CYP51A1, CHKB, EPHX1, DHRS9, LSS, CYB5A, COMT, LMAN1, CYP3A43, FMO5, DGCR2, BCL2, SPCS3, STEAP2, ACSL6 713 244 12782 1.4694318625985792 1.0 0.7273479970834559 73.0435239485193 GOTERM_CC_FAT GO:0005792~microsome 19 1.6964285714285714 0.11251309980309004 ALS2, CYP3A4, CPT1B, CYP3A5, CYP3A7, SEC11C, CYP51A1, CHKB, EPHX1, DHRS9, LSS, CYB5A, COMT, LMAN1, CYP3A43, FMO5, DGCR2, BCL2, SPCS3, ACSL6 713 237 12782 1.4371911635035892 1.0 0.7719627972042971 81.9223529381791 Annotation Cluster 17 Enrichment Score: 1.1477226597664751 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044449~contractile fiber part 14 1.25 0.01003137810653694 ALDOA, SRI, ACTC1, PDLIM3, MYOZ2, LMAN1, MYOT, MYL9, DES, SORBS2, PSEN2, MYH11, OBSL1, MYOM1 713 113 12782 2.221052762228649 0.9923237272791423 0.5012549160111905 13.452706704678906 GOTERM_CC_FAT GO:0043292~contractile fiber 14 1.25 0.017136137758820398 ALDOA, SRI, ACTC1, PDLIM3, MYOZ2, LMAN1, MYOT, MYL9, DES, SORBS2, PSEN2, MYH11, OBSL1, MYOM1 713 121 12782 2.0742062986102257 0.9997632465008459 0.5660600439661085 21.94023807570534 SP_PIR_KEYWORDS muscle protein 8 0.7142857142857143 0.039774790534075816 ACTC1, DES, MYH11, MYL12B, MYL12A, MYOM1, MYOT, MYL9 1027 60 19235 2.4972411554690037 0.9999999998480087 0.6101396097423274 44.75227061497593 GOTERM_MF_FAT GO:0008307~structural constituent of muscle 6 0.5357142857142857 0.08263621561721127 SORBS2, MYH11, PDLIM3, MYOM1, MYOT, MYL9 725 42 12983 2.558226600985222 1.0 0.9436484152969902 73.76154929533601 GOTERM_CC_FAT GO:0016459~myosin complex 7 0.625 0.1526511421938067 MYO1B, MYO3B, MYH11, MYL12B, MYL12A, MYOM1, MYL9 713 65 12782 1.930607401014133 1.0 0.8444195502879884 90.68665165424251 GOTERM_CC_FAT GO:0005859~muscle myosin complex 3 0.26785714285714285 0.307257322009368 MYH11, MYOM1, MYL9 713 20 12782 2.6890603085553995 1.0 0.9234397030697409 99.48079608661652 GOTERM_CC_FAT GO:0016460~myosin II complex 3 0.26785714285714285 0.3488889509782188 MYH11, MYOM1, MYL9 713 22 12782 2.4446002805049085 1.0 0.9345772341010842 99.78639604563242 Annotation Cluster 18 Enrichment Score: 1.1080979232961767 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010033~response to organic substance 56 5.0 0.009833515777647572 TLR3, AP3S1, PMAIP1, VGF, AGXT, DGCR8, VN1R5, CASP8, VPS4B, CHRNA7, LBP, LOX, CCNA2, IHH, EGR1, COLEC12, PTPRN, CDO1, MAPK1, GNAL, CAPN10, GNB2, STEAP2, CALCR, HMGB2, NNAT, COL3A1, TAC1, ASNS, GNG11, COMT, ATP5G3, SRC, SRRT, BCL2, HSPE1, SH2B2, PGGT1B, ACTC1, PTPN2, EPHX1, MSTN, MALT1, CRIPAK, STAT1, ANXA5, HERPUD2, ABCB4, HSPA4L, ARSA, MC4R, DNAJB2, JAK2, HSPD1, PARP1, VLDLR 751 721 13528 1.3990924721730251 0.9999999999986 0.8774926241152007 16.163998921122957 GOTERM_BP_FAT GO:0009725~response to hormone stimulus 29 2.5892857142857144 0.05522010305915753 CALCR, HMGB2, AP3S1, TAC1, GNG11, VGF, AGXT, SRC, BCL2, SH2B2, LOX, CCNA2, IHH, PTPN2, MSTN, CRIPAK, STAT1, PTPRN, CDO1, ABCB4, MAPK1, CAPN10, GNB2, ARSA, MC4R, JAK2, PARP1, STEAP2, VLDLR 751 367 13528 1.4233955089852948 1.0 0.9693909581297522 63.70264559507186 GOTERM_BP_FAT GO:0009719~response to endogenous stimulus 31 2.767857142857143 0.06605601955969592 CALCR, HMGB2, AP3S1, TAC1, GNG11, ASNS, VGF, AGXT, SRC, BCL2, SH2B2, LOX, CCNA2, IHH, PTPN2, MSTN, CRIPAK, CDO1, STAT1, PTPRN, ABCB4, MAPK1, GNAL, CAPN10, GNB2, ARSA, MC4R, JAK2, PARP1, STEAP2, VLDLR 751 405 13528 1.378796994953231 1.0 0.9635362070854764 70.45424922237864 GOTERM_BP_FAT GO:0043434~response to peptide hormone stimulus 14 1.25 0.08596154308228732 PTPN2, AP3S1, VGF, STAT1, CDO1, PTPRN, CAPN10, BCL2, MC4R, SH2B2, JAK2, PARP1, CCNA2, VLDLR 751 154 13528 1.6375741435661542 1.0 0.9711749907257586 79.88275082449647 GOTERM_BP_FAT GO:0032868~response to insulin stimulus 10 0.8928571428571428 0.10252680857991919 CAPN10, PTPN2, MC4R, AP3S1, SH2B2, PTPRN, PARP1, VGF, STAT1, VLDLR 751 100 13528 1.8013315579227698 1.0 0.9714700066260075 85.48362672225394 GOTERM_BP_FAT GO:0032869~cellular response to insulin stimulus 7 0.625 0.1743134760843781 CAPN10, PTPN2, AP3S1, SH2B2, PARP1, STAT1, VLDLR 751 68 13528 1.8543118978616748 1.0 0.9849846212410408 96.71977868968814 GOTERM_BP_FAT GO:0032870~cellular response to hormone stimulus 10 0.8928571428571428 0.3177777601660172 CAPN10, GNB2, PTPN2, AP3S1, SH2B2, JAK2, GNG11, PARP1, STAT1, VLDLR 751 133 13528 1.35438463001712 1.0 0.9875062149742191 99.89108744735731 Annotation Cluster 19 Enrichment Score: 1.07946945037879 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS motor protein 14 1.25 0.02408695098519501 KIF22, DNAH14, MYO1B, MYO3B, MYL12B, MYL12A, DNAH7, MYL9, KIF1A, SLC26A5, MYH11, DYNC1I2, KIF20A, KIF26B 1027 132 19235 1.9864418282139802 0.9999987352734355 0.5956105880276226 29.983167881786542 GOTERM_BP_FAT GO:0007018~microtubule-based movement 12 1.0714285714285714 0.04866914382621216 KIF22, NDE1, KIF1A, HTT, DNAH14, TUBB6, TUBA4A, TUBA4B, DNAH7, DYNC1I2, KIF26B, KIF20A 751 113 13528 1.9129184685905518 1.0 0.9594321344234683 58.94040928160764 GOTERM_MF_FAT GO:0003774~motor activity 14 1.25 0.05361425076756111 KIF22, DNAH14, MYO1B, MYO3B, MYL12B, MYL12A, DNAH7, MYL9, KIF1A, SLC26A5, MYH11, DYNC1I2, KIF20A, KIF26B 725 142 12983 1.7655366682855755 1.0 0.9296466823373479 57.46314865237028 SP_PIR_KEYWORDS myosin 6 0.5357142857142857 0.13450563254757664 MYO1B, MYO3B, MYH11, MYL12B, MYL12A, MYL9 1027 51 19235 2.2034480783550032 1.0 0.7442992814985063 87.8975515275046 GOTERM_CC_FAT GO:0016459~myosin complex 7 0.625 0.1526511421938067 MYO1B, MYO3B, MYH11, MYL12B, MYL12A, MYOM1, MYL9 713 65 12782 1.930607401014133 1.0 0.8444195502879884 90.68665165424251 GOTERM_MF_FAT GO:0003777~microtubule motor activity 7 0.625 0.258480027844674 KIF22, KIF1A, DNAH14, DNAH7, DYNC1I2, KIF26B, KIF20A 725 77 12983 1.627962382445141 1.0 0.9910326549668913 99.03323367244347 Annotation Cluster 20 Enrichment Score: 1.0681952331743974 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007368~determination of left/right symmetry 6 0.5357142857142857 0.08106071005410247 BBS7, DISP1, TGIF1, RFX3, TBX1, RTTN 751 42 13528 2.5733307970325283 1.0 0.9677301435718144 77.86897197894633 GOTERM_BP_FAT GO:0009855~determination of bilateral symmetry 6 0.5357142857142857 0.08776107784401374 BBS7, DISP1, TGIF1, RFX3, TBX1, RTTN 751 43 13528 2.5134858947759575 1.0 0.9675600347200944 80.57777206379373 GOTERM_BP_FAT GO:0009799~determination of symmetry 6 0.5357142857142857 0.08776107784401374 BBS7, DISP1, TGIF1, RFX3, TBX1, RTTN 751 43 13528 2.5134858947759575 1.0 0.9675600347200944 80.57777206379373 Annotation Cluster 21 Enrichment Score: 1.0459953606364707 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR002099:DNA mismatch repair protein 4 0.35714285714285715 0.019783486147079258 PMS2, ZNF12, PMS2CL, PMS1 920 11 16659 6.584584980237154 0.9999999999959653 0.9274594988921718 27.866833565476057 GOTERM_BP_FAT GO:0006298~mismatch repair 5 0.4464285714285714 0.04686664718811671 EXO1, PMS2, ZNF12, PMS2CL, PMS1 751 25 13528 3.6026631158455396 1.0 0.9636452882068104 57.5300860511725 INTERPRO IPR003594:ATP-binding region, ATPase-like 5 0.4464285714285714 0.0808004561400942 PDK1, SMCHD1, PMS2, ZNF12, PMS1 920 30 16659 3.0179347826086955 1.0 0.9934501651997225 74.77479010122217 SMART SM00387:HATPase_c 5 0.4464285714285714 0.0859053616554708 PDK1, SMCHD1, PMS2, ZNF12, PMS1 513 30 9079 2.9496426250812213 0.9999999999754757 0.982954908969741 69.34378954336047 GOTERM_MF_FAT GO:0030983~mismatched DNA binding 4 0.35714285714285715 0.08604904038077521 PMS2, ZNF12, PMS2CL, PMS1 725 19 12983 3.770018148820326 1.0 0.9443851614420733 75.23555243314107 GOTERM_MF_FAT GO:0043566~structure-specific DNA binding 11 0.9821428571428571 0.29002574771161554 EXO1, EGR1, HMGB2, MCM7, SP3, PMS2, ZNF12, PMS2CL, HSPD1, PMS1, FEV 725 145 12983 1.3585065398335316 1.0 0.9910295379139573 99.50745319827065 GOTERM_MF_FAT GO:0003690~double-stranded DNA binding 8 0.7142857142857143 0.29665324089713174 EGR1, HMGB2, SP3, PMS2, ZNF12, PMS2CL, PMS1, FEV 725 97 12983 1.4769143263419837 1.0 0.9908488404125965 99.57414211958088 Annotation Cluster 22 Enrichment Score: 1.0455986045155135 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE DNA-binding region:DM 3 0.26785714285714285 0.03717273472930775 DMRT3, DMRT1, DMRT2 1024 6 19113 9.33251953125 1.0 0.9999991547172156 48.86883897113757 INTERPRO IPR001275:DM DNA-binding 3 0.26785714285714285 0.05305141074306079 DMRT3, DMRT1, DMRT2 920 7 16659 7.760403726708074 1.0 0.988590008698113 58.98040485308673 SMART SM00301:DM 3 0.26785714285714285 0.055181881837397466 DMRT3, DMRT1, DMRT2 513 7 9079 7.584795321637427 0.9999998028876208 0.9789293237113555 52.63000382671377 GOTERM_BP_FAT GO:0007548~sex differentiation 9 0.8035714285714285 0.6037923765936329 ERMP1, HMGB2, DMRT3, BCL2, DMRT1, DMRT2, INHA, HSD17B4, VGF 751 151 13528 1.0736413259142334 1.0 0.9965081192667111 99.99999329256066 Annotation Cluster 23 Enrichment Score: 1.0378013265657946 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS gap junction 5 0.4464285714285714 0.04163487628747041 GJD2, GJA8, PANX2, GJA5, GJC3 1027 25 19235 3.7458617332035056 0.9999999999483861 0.5978970975143841 46.29634692162079 GOTERM_CC_FAT GO:0005921~gap junction 5 0.4464285714285714 0.07510975984339635 GJD2, GJA8, PANX2, GJA5, GJC3 713 29 12782 3.0908739178797697 1.0 0.7037465709828881 67.3366909250249 INTERPRO IPR000500:Connexins 4 0.35714285714285715 0.09486206667382867 GJD2, GJA8, GJA5, GJC3 920 20 16659 3.6215217391304346 1.0 0.9946708307376539 80.39411491623471 INTERPRO IPR019570:Gap junction protein, cysteine-rich domain 4 0.35714285714285715 0.09486206667382867 GJD2, GJA8, GJA5, GJC3 920 20 16659 3.6215217391304346 1.0 0.9946708307376539 80.39411491623471 INTERPRO IPR017991:Connexin region 4 0.35714285714285715 0.10634340490335653 GJD2, GJA8, GJA5, GJC3 920 21 16659 3.449068322981366 1.0 0.9948683980872918 84.08695803357283 INTERPRO IPR017990:Connexin, conserved site 4 0.35714285714285715 0.10634340490335653 GJD2, GJA8, GJA5, GJC3 920 21 16659 3.449068322981366 1.0 0.9948683980872918 84.08695803357283 INTERPRO IPR013092:Connexin, N-terminal 4 0.35714285714285715 0.10634340490335653 GJD2, GJA8, GJA5, GJC3 920 21 16659 3.449068322981366 1.0 0.9948683980872918 84.08695803357283 SMART SM00037:CNX 4 0.35714285714285715 0.11167400279123349 GJD2, GJA8, GJA5, GJC3 513 21 9079 3.371020142949967 0.9999999999999897 0.9821572968085279 78.95992250022626 GOTERM_CC_FAT GO:0005922~connexon complex 4 0.35714285714285715 0.12088306905258034 GJD2, GJA8, GJA5, GJC3 713 22 12782 3.259467040673212 1.0 0.7889607527801852 84.21778138142282 Annotation Cluster 24 Enrichment Score: 1.0029027042085146 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007017~microtubule-based process 26 2.3214285714285716 0.0037098864685614556 KIF22, HAUS3, CEP120, DNAH14, CETN1, DNAH7, SPC25, NDE1, TUBGCP6, PEX1, SEH1L, MAPT, NEFH, TUBB6, RANBP1, PPP4C, HTT, PCNT, NDC80, TACC3, KIF1A, TUBA4A, TUBA4B, DYNC1I2, KIF26B, KIF20A 751 253 13528 1.8511707709878265 0.9999651953871034 0.7692769561657462 6.416024589046721 GOTERM_BP_FAT GO:0007018~microtubule-based movement 12 1.0714285714285714 0.04866914382621216 KIF22, NDE1, KIF1A, HTT, DNAH14, TUBB6, TUBA4A, TUBA4B, DNAH7, DYNC1I2, KIF26B, KIF20A 751 113 13528 1.9129184685905518 1.0 0.9594321344234683 58.94040928160764 GOTERM_CC_FAT GO:0015630~microtubule cytoskeleton 36 3.214285714285714 0.22681066781010512 ALS2, HAUS3, KIF22, SDCCAG8, BBS5, MAEA, CEP120, VAPA, CEP76, DNAH14, BBS9, AKAP9, CETN1, DNAH7, FAM83D, TUBGCP6, CDC45, MAP1LC3C, NDE1, CEP170, MAPT, TUBB6, RANBP1, PPP4C, CEP192, PCNT, PLK4, KIF1A, MAD2L1, SPAG4, TUBA4A, TUBA4B, SEPT7, DYNC1I2, KIF26B, KIF20A 713 549 12782 1.1755454900788633 1.0 0.8869242180693349 97.4933388198286 SP_PIR_KEYWORDS microtubule 16 1.4285714285714286 0.2523600507574826 KIF22, HAUS3, DNAH14, DNAH7, KIF1A, NDE1, MAP1LC3C, TUBGCP6, MAPT, CEP170, TUBB6, TUBA4A, TUBA4B, DYNC1I2, KIF20A, KIF26B 1027 231 19235 1.2972681327111708 1.0 0.8380004784989329 98.57595009997428 GOTERM_MF_FAT GO:0003777~microtubule motor activity 7 0.625 0.258480027844674 KIF22, KIF1A, DNAH14, DNAH7, DYNC1I2, KIF26B, KIF20A 725 77 12983 1.627962382445141 1.0 0.9910326549668913 99.03323367244347 GOTERM_CC_FAT GO:0005874~microtubule 18 1.607142857142857 0.3596320377959295 KIF22, HAUS3, VAPA, DNAH14, DNAH7, KIF1A, NDE1, MAP1LC3C, TUBGCP6, SPAG4, MAPT, CEP170, TUBB6, TUBA4A, TUBA4B, DYNC1I2, KIF20A, KIF26B 713 274 12782 1.1776906460826568 1.0 0.9321861056528478 99.83170714223493 Annotation Cluster 25 Enrichment Score: 0.9926053068036051 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS cell cycle 41 3.660714285714286 0.0017375672722289058 SEPT5, HAUS3, MAEA, ZAK, LIN9, DBF4, NEK1, AHCTF1, CETN1, ANLN, FAM83D, SPC25, CDC45, NDE1, MCM7, SEH1L, VPS4B, STAG3, TLK1, CCNA2, DSN1, TP53BP2, SGOL2, RBL1, CDC23, CDK6, NDC80, PIM3, STRADB, CDC25C, MAPK1, UHRF2, CHMP1B, MAD2L1, MAPK12, DMTF1, MAPK3, LIN54, SEPT7, TXNL4A, BLCAP 1027 461 19235 1.6657302718150078 0.6204112223866007 0.17612244241666764 2.510293652767115 SP_PIR_KEYWORDS kinetochore 9 0.8035714285714285 0.018325436868370473 SPC25, NDE1, MAD2L1, SEH1L, DSN1, SGOL2, AHCTF1, NDC80, SEPT7 1027 63 19235 2.67561552371679 0.9999664325330805 0.5209037682842219 23.691246150083877 SP_PIR_KEYWORDS cell division 23 2.0535714285714284 0.025700966960829345 SEPT5, HAUS3, MAEA, DSN1, SGOL2, NEK1, CDC23, AHCTF1, CDK6, NDC80, CETN1, ANLN, CDC25C, FAM83D, SPC25, NDE1, CHMP1B, MAD2L1, SEH1L, VPS4B, CCNA2, SEPT7, TXNL4A 1027 264 19235 1.6317200731757695 0.9999994969684319 0.5739058198658438 31.657065753750224 GOTERM_CC_FAT GO:0000779~condensed chromosome, centromeric region 9 0.8035714285714285 0.02953417388702654 SPC25, NDE1, MAD2L1, SEH1L, DSN1, SGOL2, AHCTF1, NDC80, SEPT7 713 66 12782 2.4446002805049085 0.9999994854125384 0.5954555941550497 34.923797827874296 SP_PIR_KEYWORDS mitosis 17 1.5178571428571428 0.035901399079944656 ACTB, HAUS3, DSN1, NEK1, CDC23, NDC80, CETN1, ANLN, CDC25C, FAM83D, SPC25, NDE1, MAD2L1, SEH1L, SEPT7, CCNA2, TXNL4A 1027 183 19235 1.7398811329087318 0.9999999985689688 0.5874629061743475 41.403274662269894 GOTERM_CC_FAT GO:0000777~condensed chromosome kinetochore 8 0.7142857142857143 0.041237714267323616 SPC25, NDE1, MAD2L1, SEH1L, DSN1, AHCTF1, NDC80, SEPT7 713 58 12782 2.472699134303816 0.9999999985331522 0.6032910054911295 45.309594104735275 GOTERM_CC_FAT GO:0000793~condensed chromosome 13 1.1607142857142858 0.055834331719524746 HMGB2, DSN1, SGOL2, AHCTF1, NDC80, SPC25, NDE1, MAD2L1, RGS12, SEH1L, STAG3, SEPT7, TOP3B 713 129 12782 1.8066038248692606 0.9999999999991123 0.6704424143725947 56.10331808950373 GOTERM_BP_FAT GO:0051301~cell division 24 2.142857142857143 0.06324939574871101 SEPT5, HAUS3, MAEA, DSN1, SGOL2, NEK1, CDC23, AHCTF1, CDK6, NDC80, CETN1, ANLN, CDC25C, FAM83D, SPC25, TOP1, NDE1, CHMP1B, MAD2L1, SEH1L, VPS4B, CCNA2, SEPT7, TXNL4A 751 295 13528 1.4654900810219142 1.0 0.9688973863864928 68.82944311850675 GOTERM_CC_FAT GO:0000776~kinetochore 9 0.8035714285714285 0.06402420691716394 SPC25, KIF22, NDE1, MAD2L1, SEH1L, DSN1, AHCTF1, NDC80, SEPT7 713 77 12782 2.0953716690042072 0.9999999999999868 0.6677941783030577 61.25537117020562 GOTERM_BP_FAT GO:0007059~chromosome segregation 9 0.8035714285714285 0.0793319210993508 SPC25, MAD2L1, SEH1L, DSN1, SGOL2, STAG3, CDC23, NDC80, TOP3B 751 81 13528 2.0014795088030772 1.0 0.971762659412687 77.11428192853924 GOTERM_BP_FAT GO:0022403~cell cycle phase 31 2.767857142857143 0.0807829532611754 HAUS3, KIF22, CEP120, DBF4, NEK1, CETN1, ANLN, ZNF655, FAM83D, SPC25, NDE1, SEH1L, BCL2, STAG3, RANBP1, DNAJC2, CCNA2, NFATC1, EXO1, DSN1, SGOL2, PCNT, CDC23, CDK6, NDC80, TACC3, CDC25C, BOLL, MAD2L1, SEPT7, TXNL4A 751 414 13528 1.3488231472368564 1.0 0.9689579158090841 77.74932453874165 GOTERM_BP_FAT GO:0007049~cell cycle 53 4.732142857142857 0.08765003445963701 SEPT5, KIF22, MAEA, ZAK, DBF4, BTRC, FAM83D, NDE1, CDC45, MCM7, SEH1L, VPS4B, STAG3, RANBP1, TLK1, CCNA2, DNAJC2, DSN1, SGOL2, RBL1, CDK6, INHA, TACC3, BOLL, MAPK1, CHMP1B, MAD2L1, UHRF2, MAPK3, PRDM5, SEPT7, HAUS3, CEP120, LIN9, NEK1, CETN1, ANLN, ZNF655, SPC25, BCL2, NFATC1, EXO1, TP53BP2, PCNT, CDC23, NDC80, STRADB, CDC25C, MAPK12, DMTF1, PSMC2, GAS2L1, TXNL4A 751 776 13528 1.2302908836328197 1.0 0.9689054496876274 80.53554930614064 GOTERM_BP_FAT GO:0000279~M phase 25 2.232142857142857 0.10480791286190158 KIF22, HAUS3, CEP120, NEK1, CETN1, ANLN, FAM83D, SPC25, NDE1, SEH1L, STAG3, RANBP1, CCNA2, EXO1, DSN1, PCNT, SGOL2, CDC23, NDC80, TACC3, CDC25C, BOLL, MAD2L1, SEPT7, TXNL4A 751 329 13528 1.3687929771449618 1.0 0.9702505717902379 86.12798955711244 GOTERM_BP_FAT GO:0048285~organelle fission 18 1.607142857142857 0.13519017380813295 HAUS3, KIF22, DSN1, NEK1, CDC23, NDC80, CETN1, ANLN, CDC25C, FAM83D, FIS1, SPC25, NDE1, MAD2L1, SEH1L, SEPT7, CCNA2, TXNL4A 751 229 13528 1.4158938009873299 1.0 0.9772822417965453 92.50790721388002 GOTERM_BP_FAT GO:0000280~nuclear division 17 1.5178571428571428 0.16227069571412275 HAUS3, KIF22, DSN1, NEK1, CDC23, NDC80, CETN1, ANLN, CDC25C, FAM83D, SPC25, NDE1, MAD2L1, SEH1L, SEPT7, CCNA2, TXNL4A 751 220 13528 1.391938022031231 1.0 0.9824316525372268 95.75286341026379 GOTERM_BP_FAT GO:0007067~mitosis 17 1.5178571428571428 0.16227069571412275 HAUS3, KIF22, DSN1, NEK1, CDC23, NDC80, CETN1, ANLN, CDC25C, FAM83D, SPC25, NDE1, MAD2L1, SEH1L, SEPT7, CCNA2, TXNL4A 751 220 13528 1.391938022031231 1.0 0.9824316525372268 95.75286341026379 GOTERM_BP_FAT GO:0000087~M phase of mitotic cell cycle 17 1.5178571428571428 0.1797338696718558 HAUS3, KIF22, DSN1, NEK1, CDC23, NDC80, CETN1, ANLN, CDC25C, FAM83D, SPC25, NDE1, MAD2L1, SEH1L, SEPT7, CCNA2, TXNL4A 751 224 13528 1.3670819859235304 1.0 0.9831561621977706 97.08344241479917 GOTERM_BP_FAT GO:0022402~cell cycle process 37 3.303571428571429 0.21711440006927302 HAUS3, KIF22, CEP120, ZAK, BTRC, DBF4, NEK1, CETN1, ANLN, ZNF655, FAM83D, SPC25, NDE1, SEH1L, BCL2, STAG3, RANBP1, DNAJC2, CCNA2, NFATC1, EXO1, DSN1, SGOL2, PCNT, CDC23, CDK6, NDC80, INHA, TACC3, CDC25C, BOLL, MAD2L1, MAPK12, PSMC2, GAS2L1, SEPT7, TXNL4A 751 565 13528 1.1796330556308403 1.0 0.9837922066347253 98.73095921774394 GOTERM_BP_FAT GO:0000278~mitotic cell cycle 25 2.232142857142857 0.24435789112300588 KIF22, HAUS3, DBF4, BTRC, NEK1, CETN1, ANLN, FAM83D, SPC25, NDE1, SEH1L, BCL2, CCNA2, DNAJC2, NFATC1, DSN1, CDC23, NDC80, CDK6, CDC25C, MAD2L1, PSMC2, PRDM5, SEPT7, TXNL4A 751 370 13528 1.217115917515385 1.0 0.9822365574288782 99.3254049121428 GOTERM_CC_FAT GO:0000775~chromosome, centromeric region 10 0.8928571428571428 0.25403992303432177 SPC25, KIF22, NDE1, MAD2L1, SEH1L, DSN1, SGOL2, AHCTF1, NDC80, SEPT7 713 124 12782 1.4457313486856986 1.0 0.8980438685947016 98.50042557114853 GOTERM_BP_FAT GO:0000070~mitotic sister chromatid segregation 4 0.35714285714285715 0.3220749149897021 MAD2L1, SEH1L, CDC23, NDC80 751 36 13528 2.0014795088030772 1.0 0.9877246963956805 99.902698545993 GOTERM_BP_FAT GO:0000819~sister chromatid segregation 4 0.35714285714285715 0.3375344566127625 MAD2L1, SEH1L, CDC23, NDC80 751 37 13528 1.9473854680246159 1.0 0.9882369591368333 99.93552649686761 GOTERM_CC_FAT GO:0005819~spindle 10 0.8928571428571428 0.4345645951950262 FAM83D, HAUS3, KIF22, NDE1, TUBGCP6, MAEA, MAD2L1, CEP170, CETN1, SEPT7 713 147 12782 1.2195284846056236 1.0 0.9498800370098198 99.9717148634381 GOTERM_CC_FAT GO:0005694~chromosome 23 2.0535714285714284 0.8013593645136963 KIF22, THAP7, HMGB2, SMCHD1, DSN1, SGOL2, HIRA, AHCTF1, NDC80, SPC25, TOP1, NDE1, MAD2L1, MCM7, RGS12, SEH1L, PRDM6, HNRNPD, STAG3, LIN54, CHD6, SEPT7, TOP3B 713 460 12782 0.8963534361851332 1.0 0.990139772732685 99.99999999126908 GOTERM_CC_FAT GO:0044427~chromosomal part 14 1.25 0.9843429958326979 KIF22, DSN1, SGOL2, HIRA, AHCTF1, NDC80, SPC25, NDE1, MCM7, MAD2L1, SEH1L, STAG3, CHD6, SEPT7 713 386 12782 0.6502045651083868 1.0 0.9999584746792044 100.0 Annotation Cluster 26 Enrichment Score: 0.9865152314645292 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA h_biopeptidesPathway:Bioactive Peptide Induced Signaling Pathway 6 0.5357142857142857 0.029691825136705277 MAPK1, GNGT1, PLCG1, MAPT, MAPK3, JAK2 87 30 1437 3.303448275862069 0.9967428244687757 0.6818966573542972 31.24483501178418 BIOCARTA h_epoPathway:EPO Signaling Pathway 4 0.35714285714285715 0.08805856020258128 PLCG1, MAPK3, JAK2, EPO 87 18 1437 3.6704980842911876 0.9999999752417068 0.7965207801979448 68.19877309205215 BIOCARTA h_TPOPathway:TPO Signaling Pathway 4 0.35714285714285715 0.11301026459801083 PLCG1, MAPK3, JAK2, STAT1 87 20 1437 3.3034482758620687 0.9999999998727866 0.8035821653375691 77.47321300928786 BIOCARTA h_ghPathway:Growth Hormone Signaling Pathway 3 0.26785714285714285 0.3831887126887804 PLCG1, MAPK3, JAK2 87 22 1437 2.2523510971786833 1.0 0.9274183496133456 99.75346428844685 Annotation Cluster 27 Enrichment Score: 0.9808363532461655 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA h_mrpPathway:Multi-Drug Resistance Factors 4 0.35714285714285715 0.0036315171109495823 ABCB11, ABCB1, ABCC1, ABCB4 87 6 1437 11.011494252873565 0.49904757606145145 0.49904757606145145 4.420990018568405 UP_SEQ_FEATURE domain:ABC transmembrane type-1 1 5 0.4464285714285714 0.006928178231639916 ABCB11, ABCB1, ABCC1, ABCB4, ABCC6 1024 15 19113 6.2216796875 0.9999999842230534 0.9887925776354164 11.583052356489343 UP_SEQ_FEATURE domain:ABC transmembrane type-1 2 5 0.4464285714285714 0.006928178231639916 ABCB11, ABCB1, ABCC1, ABCB4, ABCC6 1024 15 19113 6.2216796875 0.9999999842230534 0.9887925776354164 11.583052356489343 INTERPRO IPR001140:ABC transporter, transmembrane region 6 0.5357142857142857 0.008932443816093445 ABCB11, ABCB1, ABCC1, ABCB6, ABCB4, ABCC6 920 24 16659 4.526902173913043 0.9999923514460032 0.8141841473931999 13.643050465131967 PIR_SUPERFAMILY PIRSF002773:multidrug resistance protein 3 0.26785714285714285 0.01580961124838451 ABCB11, ABCB1, ABCB4 395 4 7396 14.043037974683543 0.997579488267958 0.6335754763053997 19.78379209393484 INTERPRO IPR017940:ABC transporter integral membrane type 1 6 0.5357142857142857 0.017225165988423087 ABCB11, ABCB1, ABCC1, ABCB6, ABCB4, ABCC6 920 28 16659 3.880201863354037 0.9999999998763661 0.9207268027403073 24.726730791624817 SP_PIR_KEYWORDS intrahepatic cholestasis 3 0.26785714285714285 0.04990985511876379 ABCB11, ATP8B1, ABCB4 1027 7 19235 8.026846571150369 0.9999999999995879 0.6259487862039855 52.69071678360564 UP_SEQ_FEATURE domain:ABC transporter 1 5 0.4464285714285714 0.08950774898288624 ABCB11, ABCB1, ABCC1, ABCB4, ABCC6 1024 32 19113 2.916412353515625 1.0 0.999983525550143 80.99398863101416 UP_SEQ_FEATURE domain:ABC transporter 2 5 0.4464285714285714 0.08950774898288624 ABCB11, ABCB1, ABCC1, ABCB4, ABCC6 1024 32 19113 2.916412353515625 1.0 0.999983525550143 80.99398863101416 INTERPRO IPR003593:ATPase, AAA+ type, core 13 1.1607142857142858 0.10082566438236382 ABCB11, ABCB1, AFG3L2, DNAH7, ABCB6, ABCB4, NVL, MCM7, PEX1, PSMC2, VPS4B, ABCC1, ABCC6 920 144 16659 1.6347146739130434 1.0 0.9943056247505192 82.40235830565224 COG_ONTOLOGY Defense mechanisms 4 0.35714285714285715 0.10640769869641559 ABCB11, ABCB1, ABCC1, ABCB4 109 21 1950 3.4076015727391877 0.9463431861588244 0.9463431861588244 60.25292331275125 SMART SM00382:AAA 13 1.1607142857142858 0.11274554992146166 ABCB11, ABCB1, AFG3L2, DNAH7, ABCB6, ABCB4, NVL, MCM7, PEX1, PSMC2, VPS4B, ABCC1, ABCC6 513 144 9079 1.5977230885856617 0.9999999999999926 0.9730908028741452 79.29156081524036 KEGG_PATHWAY hsa02010:ABC transporters 6 0.5357142857142857 0.11497590439980655 ABCB11, ABCB1, ABCC1, ABCB6, ABCB4, ABCC6 301 44 5085 2.303684687405618 0.9999999977422259 0.8096848450994698 77.22506329737642 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 1 5 0.4464285714285714 0.11527236861171894 ABCB11, ABCB1, ABCC1, ABCB4, ABCC6 1024 35 19113 2.6664341517857144 1.0 0.9999631597939792 88.56754213504894 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 2 5 0.4464285714285714 0.11527236861171894 ABCB11, ABCB1, ABCC1, ABCB4, ABCC6 1024 35 19113 2.6664341517857144 1.0 0.9999631597939792 88.56754213504894 INTERPRO IPR003960:ATPase, AAA-type, conserved site 5 0.4464285714285714 0.11546934862906856 NVL, PEX1, PSMC2, VPS4B, AFG3L2 920 34 16659 2.6628836317135547 1.0 0.996132947921246 86.54515054596979 INTERPRO IPR003439:ABC transporter-like 6 0.5357142857142857 0.12349110568866312 ABCB11, ABCB1, ABCC1, ABCB6, ABCB4, ABCC6 920 48 16659 2.2634510869565214 1.0 0.9955205926359836 88.40693589765965 BIOCARTA h_nuclearRsPathway:Nuclear Receptors in Lipid Metabolism and Toxicity 5 0.4464285714285714 0.16432428695595983 CYP3A43, CYP3A4, ABCB11, ABCB1, ABCB4 87 36 1437 2.294061302681992 0.9999999999999984 0.8338968739226852 89.25921341452579 INTERPRO IPR017871:ABC transporter, conserved site 6 0.5357142857142857 0.20490948353459737 ABCB11, ABCB1, ABCC1, ABCB6, ABCB4, ABCC6 920 57 16659 1.9060640732265444 1.0 0.9969414296219423 97.64472782532054 GOTERM_MF_FAT GO:0016887~ATPase activity 23 2.0535714285714284 0.2448315818051276 ATP5J2, ACTC1, HELQ, RALBP1, ABCB11, ABCB1, MOV10L1, CETN1, DNAH7, ABCB6, ABCB4, CHD1L, PEX1, ATP9B, PSMC2, VPS4B, ATP8B1, ABCC1, DHX35, HSPD1, CHD6, SMARCA2, ABCC6 725 334 12983 1.2331571340078464 1.0 0.9898846488158575 98.71709936947848 GOTERM_MF_FAT GO:0043492~ATPase activity, coupled to movement of substances 9 0.8035714285714285 0.2705437390093185 RALBP1, ABCB11, ATP9B, ATP8B1, ABCB1, ABCC1, ABCB6, ABCB4, ABCC6 725 110 12983 1.465166144200627 1.0 0.9902996885042122 99.25041832857234 INTERPRO IPR003959:ATPase, AAA-type, core 5 0.4464285714285714 0.28452438765586846 NVL, PEX1, PSMC2, VPS4B, AFG3L2 920 49 16659 1.847715173025732 1.0 0.9989602662007125 99.5802781601801 GOTERM_MF_FAT GO:0042623~ATPase activity, coupled 18 1.607142857142857 0.35916100031138753 HELQ, RALBP1, ABCB11, ABCB1, MOV10L1, CETN1, ABCB6, ABCB4, CHD1L, PEX1, ATP9B, VPS4B, ATP8B1, ABCC1, DHX35, CHD6, SMARCA2, ABCC6 725 272 12983 1.1850608519269776 1.0 0.9941653114980934 99.89947976704896 GOTERM_MF_FAT GO:0042626~ATPase activity, coupled to transmembrane movement of substances 8 0.7142857142857143 0.4066274202428998 ABCB11, ATP9B, ATP8B1, ABCB1, ABCC1, ABCB6, ABCB4, ABCC6 725 109 12983 1.3143182537171778 1.0 0.9957122649205762 99.96953413107315 GOTERM_MF_FAT GO:0016820~hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 8 0.7142857142857143 0.4251129573925112 ABCB11, ATP9B, ATP8B1, ABCB1, ABCC1, ABCB6, ABCB4, ABCC6 725 111 12983 1.290636843740292 1.0 0.9962307379041411 99.98135341534183 GOTERM_MF_FAT GO:0015399~primary active transmembrane transporter activity 8 0.7142857142857143 0.52468392297857 ABCB11, ATP9B, ATP8B1, ABCB1, ABCC1, ABCB6, ABCB4, ABCC6 725 122 12983 1.1742679479932163 1.0 0.9982038140933478 99.99902435354608 GOTERM_MF_FAT GO:0015405~P-P-bond-hydrolysis-driven transmembrane transporter activity 8 0.7142857142857143 0.52468392297857 ABCB11, ATP9B, ATP8B1, ABCB1, ABCC1, ABCB6, ABCB4, ABCC6 725 122 12983 1.1742679479932163 1.0 0.9982038140933478 99.99902435354608 GOTERM_MF_FAT GO:0015662~ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 3 0.26785714285714285 0.8032699336864526 ABCB11, ATP9B, ATP8B1 725 53 12983 1.0136369551073519 1.0 0.9998245774333405 99.99999999888726 GOTERM_MF_FAT GO:0042625~ATPase activity, coupled to transmembrane movement of ions 3 0.26785714285714285 0.9236733672125954 ABCB11, ATP9B, ATP8B1 725 74 12983 0.7259832246039143 1.0 0.9999909929146089 100.0 Annotation Cluster 28 Enrichment Score: 0.9771474809642589 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Isomerase 12 1.0714285714285714 0.055711573569849855 FKBP9, TOP1, PPIG, PPIL2, TMX3, PPIC, DSEL, PPIL3, LSS, HSD17B4, ENOSF1, TOP3B 1027 120 19235 1.8729308666017526 0.9999999999999865 0.6429844945183842 56.74284086524064 UP_SEQ_FEATURE domain:PPIase cyclophilin-type 4 0.35714285714285715 0.0684535432295853 PPIG, PPIL2, PPIC, PPIL3 1024 18 19113 4.147786458333333 1.0 0.9999979296968259 71.50989252696436 INTERPRO IPR002130:Peptidyl-prolyl cis-trans isomerase, cyclophilin-type 4 0.35714285714285715 0.10634340490335653 PPIG, PPIL2, PPIC, PPIL3 920 21 16659 3.449068322981366 1.0 0.9948683980872918 84.08695803357283 SP_PIR_KEYWORDS Rotamase 5 0.4464285714285714 0.13283806601536177 FKBP9, PPIG, PPIL2, PPIC, PPIL3 1027 37 19235 2.5309876575699364 1.0 0.7516183259212998 87.55215888096409 GOTERM_MF_FAT GO:0003755~peptidyl-prolyl cis-trans isomerase activity 5 0.4464285714285714 0.14908968465046654 FKBP9, PPIG, PPIL2, PPIC, PPIL3 725 37 12983 2.4199440820130476 1.0 0.9772486793088635 91.82770049203735 GOTERM_MF_FAT GO:0016859~cis-trans isomerase activity 5 0.4464285714285714 0.1707234013476004 FKBP9, PPIG, PPIL2, PPIC, PPIL3 725 39 12983 2.295844385499558 1.0 0.9790239582279897 94.51912223799017 Annotation Cluster 29 Enrichment Score: 0.9719635908724826 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR008072:Cytochrome P450, E-class, CYP3A 4 0.35714285714285715 6.418387843783559E-4 CYP3A43, CYP3A4, CYP3A5, CYP3A7 920 4 16659 18.107608695652175 0.5695847718861349 0.3439396154972737 1.0441059350145943 PIR_SUPERFAMILY PIRSF000051:cytochrome P450 CYP3A5 4 0.35714285714285715 0.0013843709912669641 CYP3A43, CYP3A4, CYP3A5, CYP3A7 395 5 7396 14.979240506329115 0.4076483307869946 0.12270651507836072 1.8981085138499831 INTERPRO IPR002402:Cytochrome P450, E-class, group II 4 0.35714285714285715 0.0015385998020822377 CYP3A43, CYP3A4, CYP3A5, CYP3A7 920 5 16659 14.486086956521739 0.8675747920927532 0.2860598975294557 2.4857749769792825 UP_SEQ_FEATURE metal ion-binding site:Iron (heme axial ligand) 13 1.1607142857142858 0.006041697109028472 CYP3A4, CYP3A5, STEAP4, CYP3A7, CYP51A1, CYB5A, CYP20A1, CYP4V2, CYP3A43, DGCR8, CYBRD1, STEAP2, STEAP1 1024 98 19113 2.4759745695153064 0.9999998417511221 0.994591042782367 10.17499883948595 PIR_SUPERFAMILY PIRSF000052:trichodiene oxygenase 3 0.26785714285714285 0.025426438086664265 CYP3A43, CYP3A4, CYP3A7 395 5 7396 11.234430379746835 0.9999408535714671 0.7511201196204613 29.97218706925171 SP_PIR_KEYWORDS microsome 12 1.0714285714285714 0.025831007969312314 CYP3A43, CYP3A4, FMO5, CYP3A5, CYP3A7, SEC11C, CYP51A1, SPCS3, DHRS9, EPHX1, CYB5A, ACSL6 1027 106 19235 2.120299094266135 0.9999995330115976 0.5550668307950384 31.790295514135035 GOTERM_MF_FAT GO:0009055~electron carrier activity 18 1.607142857142857 0.11157276976244157 CYP3A4, STEAP4, CYP3A5, CYP3A7, AIFM3, CYP51A1, CYP20A1, CYP4V2, GLDC, CYP3A43, FMO5, P4HA2, NDUFV2, AOX1, TXNRD2, STEAP2, STEAP1, DEGS1 725 221 12983 1.4585364331408956 1.0 0.9510381904739498 84.04074014603633 INTERPRO IPR001128:Cytochrome P450 7 0.625 0.11885800463117303 CYP3A43, CYP3A4, CYP3A5, CYP3A7, CYP51A1, CYP4V2, CYP20A1 920 61 16659 2.0779223093371346 1.0 0.9960659286192013 87.36348077328518 SP_PIR_KEYWORDS Monooxygenase 8 0.7142857142857143 0.12190388737019456 CYP3A43, CYP3A4, FMO5, CYP3A5, CYP3A7, CYP51A1, CYP4V2, CYP20A1 1027 78 19235 1.9209547349761564 1.0 0.7383945740000672 85.04977244288419 COG_ONTOLOGY Secondary metabolites biosynthesis, transport, and catabolism 7 0.625 0.14686415789508883 CYP3A43, CYP3A4, CYP3A5, CYP3A7, CYP51A1, CYP4V2, CYP20A1 109 65 1950 1.9266055045871562 0.9839130805200652 0.8731657795390582 72.81712186916526 INTERPRO IPR017973:Cytochrome P450, C-terminal region 6 0.5357142857142857 0.19508888878770103 CYP3A43, CYP3A4, CYP3A5, CYP3A7, CYP51A1, CYP4V2 920 56 16659 1.9401009316770186 1.0 0.997018539727866 97.12130044967073 SP_PIR_KEYWORDS heme 10 0.8928571428571428 0.19734605948731826 CYP3A43, CYP3A4, CYP3A5, CYP3A7, DGCR8, CYP51A1, CYBRD1, CYB5A, CYP4V2, CYP20A1 1027 121 19235 1.5478767492576468 1.0 0.8131306081493923 95.9792151105469 KEGG_PATHWAY hsa00591:Linoleic acid metabolism 4 0.35714285714285715 0.22693151455178856 CYP3A43, CYP3A4, CYP3A5, CYP3A7 301 28 5085 2.4133839582344567 1.0 0.8643691372663533 95.57448894669254 GOTERM_MF_FAT GO:0016712~oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 4 0.35714285714285715 0.2329499649167563 CYP3A43, CYP3A4, CYP3A5, CYP3A7 725 30 12983 2.38767816091954 1.0 0.9899343261015631 98.36557987083191 GOTERM_MF_FAT GO:0020037~heme binding 10 0.8928571428571428 0.23327301735971065 CYP3A43, CYP3A4, CYP3A5, EIF2AK1, CYP3A7, CYP51A1, PGRMC2, CYB5A, CYP4V2, CYP20A1 725 121 12983 1.4799658022228555 1.0 0.9890631387490223 98.3762252058911 SP_PIR_KEYWORDS chromoprotein 6 0.5357142857142857 0.23491390413014818 CYP3A4, CYP3A5, CYP3A7, CYP51A1, AOX1, CYB5A 1027 62 19235 1.812513741872664 1.0 0.823468820487057 98.00485520560048 KEGG_PATHWAY hsa00983:Drug metabolism 5 0.4464285714285714 0.24668863715715494 CYP3A43, CYP3A4, CYP3A5, TYMP, CYP3A7 301 43 5085 1.9643822915861857 1.0 0.8539666873604357 96.76578109364868 INTERPRO IPR017972:Cytochrome P450, conserved site 6 0.5357142857142857 0.2561947701621312 CYP3A43, CYP3A4, CYP3A5, CYP3A7, CYP51A1, CYP4V2 920 62 16659 1.7523492286115006 1.0 0.9990313252877858 99.20812721836349 INTERPRO IPR002401:Cytochrome P450, E-class, group I 5 0.4464285714285714 0.28452438765586846 CYP3A43, CYP3A4, CYP3A5, CYP4V2, CYP20A1 920 49 16659 1.847715173025732 1.0 0.9989602662007125 99.5802781601801 KEGG_PATHWAY hsa00140:Steroid hormone biosynthesis 5 0.4464285714285714 0.2865831233035064 CYP3A43, CYP3A4, CYP3A5, CYP3A7, COMT 301 46 5085 1.8362704030044779 1.0 0.8796140516684204 98.3269034062787 GOTERM_MF_FAT GO:0046906~tetrapyrrole binding 10 0.8928571428571428 0.29272628147586083 CYP3A43, CYP3A4, CYP3A5, EIF2AK1, CYP3A7, CYP51A1, PGRMC2, CYB5A, CYP4V2, CYP20A1 725 129 12983 1.3881849772788024 1.0 0.9908297549372475 99.53572679731894 KEGG_PATHWAY hsa00982:Drug metabolism 6 0.5357142857142857 0.30206441626428526 CYP3A43, CYP3A4, FMO5, CYP3A5, CYP3A7, AOX1 301 62 5085 1.634873003965277 1.0 0.8767513519346718 98.7173560482833 SP_PIR_KEYWORDS metalloprotein 9 0.8035714285714285 0.34217439155383633 CYP3A43, CYP3A4, CYP3A5, CYP3A7, CYP51A1, NDUFV2, AOX1, CYB5A, PPP4C 1027 124 19235 1.359385306404498 1.0 0.8800558387944747 99.78072839133756 KEGG_PATHWAY hsa00830:Retinol metabolism 5 0.4464285714285714 0.3956943004718002 CYP3A43, CYP3A4, CYP3A5, CYP3A7, DHRS9 301 54 5085 1.5642303433001108 1.0 0.9106038451875275 99.775962085279 GOTERM_MF_FAT GO:0070330~aromatase activity 3 0.26785714285714285 0.4101436160593942 CYP3A43, CYP3A5, CYP3A7 725 25 12983 2.1489103448275864 1.0 0.995696972253086 99.97221734913879 KEGG_PATHWAY hsa00980:Metabolism of xenobiotics by cytochrome P450 5 0.4464285714285714 0.47607960654878717 CYP3A43, CYP3A4, CYP3A5, CYP3A7, EPHX1 301 60 5085 1.4078073089700998 1.0 0.9038129635896166 99.96024348568953 SP_PIR_KEYWORDS electron transfer 4 0.35714285714285715 0.5029805362536823 CYP3A4, CYP3A5, CYP3A7, CYB5A 1027 50 19235 1.4983446932814022 1.0 0.9318203061089363 99.99635818665689 GOTERM_MF_FAT GO:0019825~oxygen binding 3 0.26785714285714285 0.7003142920667182 CYP3A4, CYP3A5, CYP3A7 725 43 12983 1.2493664795509223 1.0 0.9993621560597382 99.99999923801563 Annotation Cluster 30 Enrichment Score: 0.9581580212988753 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS ank repeat 20 1.7857142857142856 0.05593256724716056 SNCAIP, TRPC3, TP53BP2, TRPC7, ANKMY1, ANKRD30B, ANKAR, SHANK3, KANK1, FEM1C, ANKRD44, PPP1R16B, KRIT1, ANKRD12, GLS, ANKRD37, POTEC, ANKIB1, ASB5, ANKZF1 1027 240 19235 1.5607757221681273 0.9999999999999881 0.6328054304117083 56.89060037582681 INTERPRO IPR002110:Ankyrin 20 1.7857142857142856 0.06795768916471714 SNCAIP, TRPC3, TP53BP2, TRPC7, ANKMY1, ANKRD30B, ANKAR, SHANK3, KANK1, FEM1C, ANKRD44, PPP1R16B, KRIT1, ANKRD12, GLS, ANKRD37, POTEC, ANKIB1, ASB5, ANKZF1 920 238 16659 1.5216477895506029 1.0 0.9901497109308999 68.35222749516213 UP_SEQ_FEATURE repeat:ANK 1 19 1.6964285714285714 0.07116202866016424 SNCAIP, TRPC3, TP53BP2, TRPC7, ANKMY1, ANKRD30B, ANKAR, KANK1, SHANK3, FEM1C, ANKRD44, PPP1R16B, KRIT1, ANKRD12, ANKRD37, POTEC, ANKIB1, ASB5, ANKZF1 1024 231 19113 1.5352196631493507 1.0 0.999996999981085 72.94159751820098 UP_SEQ_FEATURE repeat:ANK 2 19 1.6964285714285714 0.07348663828851229 SNCAIP, TRPC3, TP53BP2, TRPC7, ANKMY1, ANKRD30B, ANKAR, KANK1, SHANK3, FEM1C, ANKRD44, PPP1R16B, KRIT1, ANKRD12, ANKRD37, POTEC, ANKIB1, ASB5, ANKZF1 1024 232 19113 1.5286023370150863 1.0 0.9999908492560079 74.11598079795594 SMART SM00248:ANK 20 1.7857142857142856 0.07914066239499912 SNCAIP, TRPC3, TP53BP2, TRPC7, ANKMY1, ANKRD30B, ANKAR, SHANK3, KANK1, FEM1C, ANKRD44, PPP1R16B, KRIT1, ANKRD12, GLS, ANKRD37, POTEC, ANKIB1, ASB5, ANKZF1 513 238 9079 1.4872147689485151 0.9999999998177882 0.9887250320545496 66.21928482111811 UP_SEQ_FEATURE repeat:ANK 4 14 1.25 0.08169104270207184 TRPC3, SNCAIP, TRPC7, ANKMY1, ANKRD30B, ANKAR, KANK1, SHANK3, FEM1C, ANKRD44, PPP1R16B, KRIT1, POTEC, ASB5 1024 158 19113 1.653864220727848 1.0 0.9999834744619484 77.88786668243024 UP_SEQ_FEATURE repeat:ANK 5 12 1.0714285714285714 0.09274063596387234 FEM1C, ANKRD44, PPP1R16B, SNCAIP, TRPC3, POTEC, ANKMY1, ANKRD30B, ANKAR, ASB5, SHANK3, KANK1 1024 131 19113 1.709774570610687 1.0 0.9999718753502014 82.15416846921475 UP_SEQ_FEATURE repeat:ANK 3 16 1.4285714285714286 0.09788531903520883 SNCAIP, TRPC3, TRPC7, ANKMY1, ANKRD30B, ANKAR, KANK1, SHANK3, FEM1C, ANKRD44, PPP1R16B, KRIT1, ANKRD12, ANKRD37, POTEC, ASB5 1024 194 19113 1.5393846649484535 1.0 0.9999642145661638 83.86366773747604 UP_SEQ_FEATURE repeat:ANK 6 7 0.625 0.37026704161398033 FEM1C, ANKRD44, SNCAIP, POTEC, ANKMY1, ASB5, SHANK3 1024 92 19113 1.420166015625 1.0 0.9999982877871104 99.97222874533989 UP_SEQ_FEATURE repeat:ANK 7 4 0.35714285714285715 0.6067124725433922 FEM1C, ANKRD44, POTEC, ANKMY1 1024 58 19113 1.287244073275862 1.0 0.999999952527601 99.99999334118034 Annotation Cluster 31 Enrichment Score: 0.9511592961820455 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006909~phagocytosis 7 0.625 0.04818789955476964 GULP1, CDC42SE2, ITGAV, COLEC12, LBP, MEGF10, ELMO1 751 48 13528 2.626941855304039 1.0 0.9611413700186991 58.56825948539628 GOTERM_BP_FAT GO:0010324~membrane invagination 18 1.607142857142857 0.1042467480748344 AP1B1, GULP1, SNX2, NOSTRIN, COLEC12, MEGF10, ELMO1, MARCH3, AP1S1, CDC42SE2, ITGAV, RAC1, GRK4, LBP, LRP2, STEAP2, CLTCL1, VLDLR 751 220 13528 1.4738167292095388 1.0 0.9708613717534726 85.97202504316226 GOTERM_BP_FAT GO:0006897~endocytosis 18 1.607142857142857 0.1042467480748344 AP1B1, GULP1, SNX2, NOSTRIN, COLEC12, MEGF10, ELMO1, MARCH3, AP1S1, CDC42SE2, ITGAV, RAC1, GRK4, LBP, LRP2, STEAP2, CLTCL1, VLDLR 751 220 13528 1.4738167292095388 1.0 0.9708613717534726 85.97202504316226 GOTERM_BP_FAT GO:0016192~vesicle-mediated transport 40 3.571428571428571 0.11427769488074288 CPLX4, ALS2, SNAP29, SEPT5, SEC31A, AP1B1, NAPG, GULP1, SNX2, BET1, AP3S1, NOSTRIN, LMAN1, MEGF10, SRC, AP1S1, MIA3, ITGAV, RAC1, VPS4B, RAPGEF4, LBP, RBM12, KDELR2, HTT, COLEC12, AP4M1, ELMO1, LRPAP1, MARCH3, DOC2A, TRIM36, CDC42SE2, CPNE1, GRK4, LRP2, STEAP2, CUX1, CLTCL1, KIF20A, VLDLR 751 576 13528 1.2509246930019233 1.0 0.9672921309809713 88.52538303577369 GOTERM_BP_FAT GO:0016044~membrane organization 25 2.232142857142857 0.2932101624866145 SNAP29, SEC31A, AP1B1, NAPG, VAPA, GULP1, SNX2, NOSTRIN, MEGF10, AP1S1, BCL2, ITGAV, RAC1, LBP, SCLT1, HTT, COLEC12, MARCH3, ELMO1, CDC42SE2, GRK4, STEAP2, LRP2, CLTCL1, VLDLR 751 381 13528 1.1819760878758332 1.0 0.9853359267945944 99.79526409086643 Annotation Cluster 32 Enrichment Score: 0.9379276472258804 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:F-box 8 0.7142857142857143 0.08987525947828327 BTRC, FBXW4, FBXO28, FBXL13, FBXO24, FBXO15, FBXO8, FBXL18 1024 72 19113 2.0738932291666665 1.0 0.9999745857498589 81.12937468300626 INTERPRO IPR001810:Cyclin-like F-box 8 0.7142857142857143 0.09040271873444655 BTRC, FBXW4, FBXO28, FBXL13, FBXO24, FBXO15, FBXO8, FBXL18 920 70 16659 2.0694409937888203 1.0 0.9943933198881665 78.7539227383983 SMART SM00256:FBOX 8 0.7142857142857143 0.09278119544443349 BTRC, FBXW4, FBXO28, FBXL13, FBXO24, FBXO15, FBXO8, FBXL18 513 69 9079 2.051925304404328 0.9999999999968546 0.9772589331051228 72.24413605941649 GOTERM_CC_FAT GO:0000151~ubiquitin ligase complex 8 0.7142857142857143 0.23496750127842708 BRCC3, FBXW4, PPIL2, CDC23, FBXO24, FBXO15, UBE2L3, FBXO8 713 90 12782 1.5935172198846812 1.0 0.8883773639615754 97.84676998518536 Annotation Cluster 33 Enrichment Score: 0.9208169551336508 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF037643:Casp8 and Fadd-like apoptosis regulator/caspase, types 8/10 3 0.26785714285714285 0.008193084392755247 CASP10, CFLAR, CASP8 395 3 7396 18.724050632911393 0.9553875610784114 0.46310273297362414 10.7566568100106 UP_SEQ_FEATURE domain:DED 2 3 0.26785714285714285 0.008280614470504861 CASP10, CFLAR, CASP8 1024 3 19113 18.6650390625 0.9999999995336993 0.9863939142019857 13.691152294232378 UP_SEQ_FEATURE domain:DED 1 3 0.26785714285714285 0.008280614470504861 CASP10, CFLAR, CASP8 1024 3 19113 18.6650390625 0.9999999995336993 0.9863939142019857 13.691152294232378 INTERPRO IPR011600:Peptidase C14, caspase catalytic 4 0.35714285714285715 0.04631734224303256 CASP10, CFLAR, CASP8, MALT1 920 15 16659 4.828695652173913 1.0 0.9842546099113388 53.942419519178465 INTERPRO IPR001309:Peptidase C14, ICE, catalytic subunit p20 4 0.35714285714285715 0.04631734224303256 CASP10, CFLAR, CASP8, MALT1 920 15 16659 4.828695652173913 1.0 0.9842546099113388 53.942419519178465 INTERPRO IPR001875:Death effector 3 0.26785714285714285 0.05305141074306079 CASP10, CFLAR, CASP8 920 7 16659 7.760403726708074 1.0 0.988590008698113 58.98040485308673 SMART SM00031:DED 3 0.26785714285714285 0.055181881837397466 CASP10, CFLAR, CASP8 513 7 9079 7.584795321637427 0.9999998028876208 0.9789293237113555 52.63000382671377 BIOCARTA h_fasPathway:FAS signaling pathway ( CD95 ) 5 0.4464285714285714 0.1095644012277199 CASP10, CFLAR, LMNB1, CASP8, PARP1 87 31 1437 2.664071190211346 0.9999999997342472 0.816590695640748 76.36105542874162 BBID 86.Apoptosis_Nematode&_Vert 3 0.26785714285714285 0.12461994096681506 CFLAR, BCL2, CASP8 26 9 358 4.589743589743589 0.999659749356394 0.9815541158085066 73.65401810126441 BIOCARTA h_caspasePathway:Caspase Cascade in Apoptosis 4 0.35714285714285715 0.16959830777126805 CASP10, LMNB1, CASP8, PARP1 87 24 1437 2.752873563218391 0.9999999999999996 0.8289046752098221 90.07197474987207 INTERPRO IPR015917:Peptidase C14, caspase precursor p45, core 3 0.26785714285714285 0.17878580823904877 CASP10, CFLAR, CASP8 920 14 16659 3.880201863354037 1.0 0.9981781196837055 96.00459716149608 BIOCARTA h_d4gdiPathway:D4-GDI Signaling Pathway 3 0.26785714285714285 0.18022156427800698 CASP10, CASP8, PARP1 87 13 1437 3.8116710875331563 1.0 0.8343624801058096 91.5400998482569 SMART SM00115:CASc 3 0.26785714285714285 0.18501683376233383 CASP10, CFLAR, CASP8 513 14 9079 3.7923976608187133 1.0 0.9812178643322114 93.23245940655937 GOTERM_MF_FAT GO:0004197~cysteine-type endopeptidase activity 7 0.625 0.21223189019040983 CASP10, CFLAR, CAPN10, CAPN8, CASP8, MALT1, CAPN2 725 72 12983 1.7410153256704983 1.0 0.9899088089903751 97.52877305808077 BIOCARTA h_deathPathway:Induction of apoptosis through DR3 and DR4/5 Death Receptors 4 0.35714285714285715 0.2655576850731786 CASP10, CFLAR, BCL2, CASP8 87 30 1437 2.2022988505747128 1.0 0.886043446571154 97.84207095224237 INTERPRO IPR002398:Peptidase C14, caspase precursor p45 3 0.26785714285714285 0.30319138703650256 CASP10, CFLAR, CASP8 920 20 16659 2.716141304347826 1.0 0.9986227888200117 99.72756152617909 BIOCARTA h_HivnefPathway:HIV-I Nef: negative effector of Fas and TNF 5 0.4464285714285714 0.3928167232442782 CFLAR, LMNB1, BCL2, CASP8, PARP1 87 53 1437 1.5582303188028628 1.0 0.9228532029430166 99.79724990888813 KEGG_PATHWAY hsa04210:Apoptosis 7 0.625 0.4080947343516078 CASP10, CFLAR, IL3, BCL2, CASP8, CAPN2, AKT3 301 87 5085 1.359262229350441 1.0 0.9069302412540567 99.82571962138495 BIOCARTA h_tnfr1Pathway:TNFR1 Signaling Pathway 3 0.26785714285714285 0.5455099176887992 LMNB1, CASP8, PARP1 87 30 1437 1.6517241379310346 1.0 0.9763821178776797 99.99446017366444 INTERPRO IPR011029:DEATH-like 4 0.35714285714285715 0.722615271782072 CASP10, CFLAR, CASP8, NLRP3 920 67 16659 1.08105126541207 1.0 0.9999968230498154 99.99999992135218 GOTERM_BP_FAT GO:0008624~induction of apoptosis by extracellular signals 5 0.4464285714285714 0.8748105024842399 CASP10, CFLAR, PSEN2, CASP8, RAC1 751 112 13528 0.8041658740726649 1.0 0.99989568597603 99.99999999999999 Annotation Cluster 34 Enrichment Score: 0.9187400373175985 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030175~filopodium 6 0.5357142857142857 0.01786695278407585 PPP1R9A, ENAH, NF2, FSCN1, ABI2, RAPH1 713 28 12782 3.8415147265077136 0.9998347023096303 0.5468874705898655 22.767889462055923 GOTERM_CC_FAT GO:0030027~lamellipodium 7 0.625 0.1939286769625751 ALS2, ENAH, PTPRM, NF2, RAC1, ABI2, RAPH1 713 70 12782 1.7927068723702664 1.0 0.8649938398405339 95.4469986955993 GOTERM_CC_FAT GO:0031252~cell leading edge 9 0.8035714285714285 0.5059264251616576 ALS2, ENAH, PTPRM, NF2, RAC1, ABI2, SH2B2, CDK6, RAPH1 713 138 12782 1.1691566558936521 1.0 0.9597533469173263 99.99590812267324 Annotation Cluster 35 Enrichment Score: 0.9128700235808674 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0060090~molecular adaptor activity 12 1.0714285714285714 0.0011037588203419862 CRKL, TP53BP2, BAIAP2L1, SORBS2, SLA2, CHN1, ABI2, OBSL1, SH2B2, SRC, SH3BP2, EPO 725 67 12983 3.2073288728769946 0.6161438523541771 0.38043874584846504 1.6985264267117328 INTERPRO IPR001452:Src homology-3 domain 15 1.3392857142857142 0.2877707949827273 TP53BP2, BAIAP2L1, SLA2, RIMBP3, MPP4, ABI2, NOSTRIN, SRC, SHANK3, MIA3, CRKL, PLCG1, SORBS2, MAPK8IP2, YES1 920 213 16659 1.2751837109614206 1.0 0.9988304284502931 99.61035065583586 INTERPRO IPR011511:Variant SH3 6 0.5357142857142857 0.28832595181879384 MIA3, CRKL, BAIAP2L1, RIMBP3, MPP4, SHANK3 920 65 16659 1.6714715719063544 1.0 0.9987260538111492 99.61528614752325 SMART SM00326:SH3 15 1.3392857142857142 0.31526178815211614 TP53BP2, BAIAP2L1, SLA2, RIMBP3, MPP4, ABI2, NOSTRIN, SRC, SHANK3, MIA3, CRKL, PLCG1, SORBS2, MAPK8IP2, YES1 513 213 9079 1.2463278697526288 1.0 0.986324441777481 99.31612724121202 SP_PIR_KEYWORDS sh3 domain 14 1.25 0.33050496543255437 TP53BP2, BAIAP2L1, SLA2, MPP4, ABI2, NOSTRIN, SRC, SHANK3, MIA3, CRKL, PLCG1, SORBS2, MAPK8IP2, YES1 1027 210 19235 1.2486205777345019 1.0 0.8737276841855085 99.71645581343135 UP_SEQ_FEATURE domain:SH3 12 1.0714285714285714 0.34924154217017417 MIA3, PLCG1, TP53BP2, BAIAP2L1, SLA2, MPP4, MAPK8IP2, ABI2, NOSTRIN, YES1, SRC, SHANK3 1024 177 19113 1.2654263771186443 1.0 0.9999978720443748 99.95032221052703 Annotation Cluster 36 Enrichment Score: 0.9001680179483076 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044450~microtubule organizing center part 8 0.7142857142857143 0.03495222181769606 PLK4, TUBGCP6, CEP76, CEP192, CEP170, PCNT, AKAP9, CETN1 713 56 12782 2.5610098176718092 0.9999999655588424 0.5588129568721161 39.94088887467829 GOTERM_CC_FAT GO:0005815~microtubule organizing center 19 1.6964285714285714 0.17156734277295305 ALS2, HAUS3, SDCCAG8, BBS5, CEP120, CEP192, CEP76, BBS9, PCNT, CETN1, AKAP9, PLK4, NDE1, TUBGCP6, CDC45, MAD2L1, CEP170, RANBP1, PPP4C 713 253 12782 1.3463016037563265 1.0 0.8614199505515777 93.26099017742152 GOTERM_CC_FAT GO:0005813~centrosome 17 1.5178571428571428 0.18439750394993115 ALS2, HAUS3, SDCCAG8, CEP120, CEP192, CEP76, BBS9, PCNT, CETN1, AKAP9, PLK4, NDE1, TUBGCP6, CDC45, CEP170, RANBP1, PPP4C 713 224 12782 1.3605364656381487 1.0 0.8713964754217444 94.61165540862666 GOTERM_CC_FAT GO:0015630~microtubule cytoskeleton 36 3.214285714285714 0.22681066781010512 ALS2, HAUS3, KIF22, SDCCAG8, BBS5, MAEA, CEP120, VAPA, CEP76, DNAH14, BBS9, AKAP9, CETN1, DNAH7, FAM83D, TUBGCP6, CDC45, MAP1LC3C, NDE1, CEP170, MAPT, TUBB6, RANBP1, PPP4C, CEP192, PCNT, PLK4, KIF1A, MAD2L1, SPAG4, TUBA4A, TUBA4B, SEPT7, DYNC1I2, KIF26B, KIF20A 713 549 12782 1.1755454900788633 1.0 0.8869242180693349 97.4933388198286 Annotation Cluster 37 Enrichment Score: 0.8933916045377733 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0034329~cell junction assembly 6 0.5357142857142857 0.0746439974540461 TAOK2, ITGA6, BCL2, TRIP6, CTNNA1, GJA5 751 41 13528 2.636094962813809 1.0 0.9666621915733327 74.94367140201307 GOTERM_BP_FAT GO:0034330~cell junction organization 7 0.625 0.09457474369866539 NF2, TAOK2, ITGA6, BCL2, TRIP6, CTNNA1, GJA5 751 57 13528 2.2121615623612962 1.0 0.9689915774350024 83.0093891320008 GOTERM_BP_FAT GO:0007160~cell-matrix adhesion 9 0.8035714285714285 0.11983515379709357 EPDR1, TAOK2, ITGA6, BCL2, ITGAV, COL3A1, SGCE, TRIP6, RAPH1 751 89 13528 1.8215712383488682 1.0 0.970565395788451 89.744217325445 GOTERM_BP_FAT GO:0007044~cell-substrate junction assembly 4 0.35714285714285715 0.1322041383236578 TAOK2, ITGA6, BCL2, TRIP6 751 23 13528 3.1327505355178604 1.0 0.9776830735063082 92.03271526188209 GOTERM_BP_FAT GO:0031589~cell-substrate adhesion 9 0.8035714285714285 0.1761154814690726 EPDR1, TAOK2, ITGA6, BCL2, ITGAV, COL3A1, SGCE, TRIP6, RAPH1 751 98 13528 1.654284083806625 1.0 0.984704861465696 96.84517936668378 GOTERM_BP_FAT GO:0048041~focal adhesion formation 3 0.26785714285714285 0.22143868232650876 TAOK2, BCL2, TRIP6 751 16 13528 3.377496671105193 1.0 0.983274567091393 98.85036637838091 Annotation Cluster 38 Enrichment Score: 0.8909078676665991 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0018212~peptidyl-tyrosine modification 7 0.625 0.04818789955476964 TPST2, ABI2, JAK2, RELN, CLK1, STAT1, SRC 751 48 13528 2.626941855304039 1.0 0.9611413700186991 58.56825948539628 GOTERM_BP_FAT GO:0018108~peptidyl-tyrosine phosphorylation 6 0.5357142857142857 0.1095146998281183 ABI2, JAK2, RELN, CLK1, STAT1, SRC 751 46 13528 2.349562901638395 1.0 0.9668957308487218 87.37321217090576 GOTERM_MF_FAT GO:0004715~non-membrane spanning protein tyrosine kinase activity 4 0.35714285714285715 0.4025927812737434 JAK2, CLK1, YES1, SRC 725 41 12983 1.747081581160639 1.0 0.9956900777070927 99.9661572363916 Annotation Cluster 39 Enrichment Score: 0.886208183468981 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006941~striated muscle contraction 6 0.5357142857142857 0.1095146998281183 ALDOA, ACTC1, RYR3, PSEN2, MYOM1, CHRNA1 751 46 13528 2.349562901638395 1.0 0.9668957308487218 87.37321217090576 GOTERM_BP_FAT GO:0003012~muscle system process 14 1.25 0.14068382567971643 ALDOA, ACTC1, TBX20, MSTN, GJA5, MYOT, P2RX6, DES, RYR3, PSEN2, MYH11, SCN7A, MYOM1, CHRNA1 751 168 13528 1.5011096316023083 1.0 0.9777852542610566 93.31308225131158 GOTERM_BP_FAT GO:0006936~muscle contraction 13 1.1607142857142858 0.1424488221829287 ALDOA, ACTC1, TBX20, GJA5, MYOT, P2RX6, DES, RYR3, PSEN2, MYH11, MYOM1, SCN7A, CHRNA1 751 153 13528 1.5305431537905887 1.0 0.9773980918165531 93.55392878183328 Annotation Cluster 40 Enrichment Score: 0.879700781412765 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR011600:Peptidase C14, caspase catalytic 4 0.35714285714285715 0.04631734224303256 CASP10, CFLAR, CASP8, MALT1 920 15 16659 4.828695652173913 1.0 0.9842546099113388 53.942419519178465 INTERPRO IPR001309:Peptidase C14, ICE, catalytic subunit p20 4 0.35714285714285715 0.04631734224303256 CASP10, CFLAR, CASP8, MALT1 920 15 16659 4.828695652173913 1.0 0.9842546099113388 53.942419519178465 GOTERM_BP_FAT GO:0009967~positive regulation of signal transduction 24 2.142857142857143 0.06324939574871101 ALS2, TWSG1, CSF2, VAPA, TLR3, ITPKB, SRC, GPR89B, TMED7, CASP8, RAC1, TGM2, TICAM2, LBP, EPO, CFLAR, IL3, TAOK2, MALT1, GHRH, MAPK8IP2, RELN, JAK2, CD226, IL2 751 295 13528 1.4654900810219142 1.0 0.9688973863864928 68.82944311850675 GOTERM_BP_FAT GO:0010740~positive regulation of protein kinase cascade 15 1.3392857142857142 0.08035829811436868 CSF2, IL3, CFLAR, TAOK2, VAPA, TLR3, MALT1, GPR89B, TMED7, CASP8, MAPK8IP2, TGM2, TICAM2, JAK2, EPO, IL2 751 167 13528 1.6179624771761403 1.0 0.969974109487114 77.56521765234068 GOTERM_BP_FAT GO:0010647~positive regulation of cell communication 25 2.232142857142857 0.10480791286190158 ALS2, CSF2, TWSG1, VAPA, TAC1, TLR3, ITPKB, SRC, GPR89B, TMED7, RAC1, CASP8, TICAM2, TGM2, LBP, EPO, CFLAR, IL3, TAOK2, MALT1, GHRH, MAPK8IP2, JAK2, RELN, CD226, IL2 751 329 13528 1.3687929771449618 1.0 0.9702505717902379 86.12798955711244 GOTERM_MF_FAT GO:0004197~cysteine-type endopeptidase activity 7 0.625 0.21223189019040983 CASP10, CFLAR, CAPN10, CAPN8, CASP8, MALT1, CAPN2 725 72 12983 1.7410153256704983 1.0 0.9899088089903751 97.52877305808077 GOTERM_BP_FAT GO:0010627~regulation of protein kinase cascade 18 1.607142857142857 0.22551936434996464 CSF2, IL3, CFLAR, ZAK, TAOK2, VAPA, NF2, TLR3, MALT1, GPR89B, TMED7, AIDA, CASP8, MAPK8IP2, TICAM2, TGM2, JAK2, EPO, IL2 751 249 13528 1.302167391269472 1.0 0.9826937822375955 98.9532528977751 GOTERM_MF_FAT GO:0008234~cysteine-type peptidase activity 11 0.9821428571428571 0.2616421451562426 CASP10, CFLAR, CAPN10, BRCC3, UFSP2, UFD1L, CAPN8, CASP8, OTUD7A, MALT1, CAPN2 725 141 12983 1.3970457324529224 1.0 0.9908696102403739 99.09524369160218 GOTERM_BP_FAT GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB cascade 8 0.7142857142857143 0.29164301977787294 TMED7, GPR89B, CFLAR, VAPA, CASP8, TICAM2, TGM2, TLR3, MALT1 751 97 13528 1.4856342745754803 1.0 0.9854868297528886 99.78701211042893 GOTERM_BP_FAT GO:0043122~regulation of I-kappaB kinase/NF-kappaB cascade 8 0.7142857142857143 0.3823578155259655 TMED7, GPR89B, CFLAR, VAPA, CASP8, TICAM2, TGM2, TLR3, MALT1 751 107 13528 1.3467899498487998 1.0 0.9895142166757022 99.98152663364037 Annotation Cluster 41 Enrichment Score: 0.8745531027565195 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS membrane 373 33.30357142857142 0.00507135368529395 CYP3A4, CYP3A5, FAM200A, CDIPT, SEC31A, CYP3A7, SCN3A, VAPA, PVRIG, MEGF10, GOLGA8B, CDH20, FAM171B, PRRT2, PPAPDC2, PLOD3, VPS4B, RAPGEF6, RAPGEF4, CHRNA7, SCD5, NPSR1, CHRNA1, GOLGA8A, MUC12, GJD2, SLC12A6, TMEFF2, SLC12A9, PTPRM, ABCB11, PLD5, SCN2A, UBR3, PTPRT, C1ORF101, TMEM200C, COLEC12, AP4M1, CTNNA1, PTPRN, PDCD1LG2, LPCAT4, NAPEPLD, DOC2A, RYR3, SPAG4, MC2R, ASPHD1, RAB12, CD226, ADD1, BLCAP, OR13G1, ORAI2, TPST2, ERMP1, KIAA1109, SCN1A, CLCN3, C16ORF92, LMNB1, OR2T2, OR2T1, CYP51A1, OR2T4, CHKB, OR2T3, TMX3, NPY6R, EPHB4, GPR141, SLC32A1, TMEM129, GORASP2, RAC1, POTEC, OR2T5, OR2T6, OR2T8, OR2C3, GPR155, TRPC3, MLC1, TAOK2, PCDH10, TRPC7, AFG3L2, DAGLB, TMEM191B, SEMA6A, GNGT1, EPHA4, TMEM191A, GTSCR1, CNIH3, CNIH4, CLTCL1, ALG12, GJA8, STEAP4, AP1B1, ORMDL1, GLRA3, AP3S1, APCDD1, GJA5, FAM57B, DNAJC18, SLC23A1, MAP1LC3C, AP1S1, TNFRSF11A, SLC23A3, XYLT1, MAPT, AGPAT9, TICAM2, MC5R, SLC25A1, KCNG2, IHH, KDELR2, KIAA1324L, ZDHHC4, PGAP1, ZDHHC8, CYB5A, CLIC2, OR2W5, RFTN2, OR2AE1, OR2W3, RHBDD3, ELMO1, FMN1, AQPEP, SLC26A5, CHMP1B, CHSY3, PSEN2, DOK7, CYBRD1, SLC27A6, AVEN, MOSPD3, SUSD4, SGCE, STEAP2, STEAP1, DEGS1, SNAP29, MFSD6, OR1C1, MFSD8, OR6F1, SLC39A10, TFR2, CTXN3, BET1, GNG11, CLDN12, GJC3, CLDN15, NETO1, OR2G3, FMO5, OR2G2, KIAA1432, SUMO1, GPM6A, OR2G6, DISP1, LRRTM2, BCL2, C1ORF95, MANBAL, RASA4, ACSL6, MOGAT3, CPT1B, DLGAP1, CNST, DLGAP4, RTN4R, FZD1, CRIPAK, CYP4V2, CAPN2, RAPH1, KCNV2, FZD7, MARCH3, RAB31, KREMEN1, CDH19, MC4R, ABCC1, C4ORF3, LRP2, VLDLR, ABCC6, GFRA3, QRFPR, OR2AK2, MAEA, ZAN, TLR3, ROMO1, TLR5, GPR89B, SEZ6L2, AQP12A, AQP12B, GALR1, ADIG, PGRMC2, RPN2, BRI3, SLC4A3, PQLC1, OR14C36, ATG9A, PLXNB2, PKD2L2, CBLN2, SLC25A31, ATP9B, CHPF, UPK3BL, KDSR, SLC40A1, SRI, STK16, OR2L8, ACHE, OR2L5, BBS5, GAL3ST4, FGFR3, BBS7, NAPG, PANX2, BBS9, TMEM63A, BMPR2, TMEM219, NOSTRIN, SLC38A11, LMAN1, OR2L3, OR2L13, CASD1, OR2L2, G6PC2, FIS1, KIAA1024L, MIA3, PPP1R16B, ITGAV, LMTK2, OR2T33, SCN9A, GRID2IP, OR2T35, MFAP3L, OR2T34, TMEM198, EWSR1, OR2M7, ATP5J2, NOMO3, ADAM29, SEC11C, EPHX1, ABCB1, OR2M2, REEP2, HERPUD2, ABCB6, OR2M3, OR2M4, SHANK3, OR2M5, ABCB4, SLC25A12, OR14A16, GPR35, P2RX6, OR2T29, ITGA6, OR2T27, CDC42SE2, CD274, NDUFV2, ECSCR, SPCS3, COQ10B, ADAM22, NAT8L, CLDN5, DPY19L1, MBP, CYP3A43, TMEM173, DGCR2, GPC2, OR2T10, PEX1, OR2T11, HPSE, RASL10A, SDPR, OR2T12, VN1R5, DSEL, GALNTL6, ATP8B1, SCN7A, CALCRL, GPC1, DCAF17, LBR, SLC1A1, MLANA, AKT3, PILRB, CCDC108, PILRA, RAB39B, RALBP1, SLA2, DHRS9, HEPACAM2, LPIN2, PIGN, BPI, MUC3A, COQ2, CHRM5, FAM134A, KRIT1, DPY19L2P1, ZFYVE28, OR14I1, MFSD10, C16ORF54, CUX1, GALNT3, NDUFB3, PHLPP1, CALCR, CPLX4, GALNT7, TMEM194B, LMF2, COMT, ATP5G3, MYOT, SCARF2, TMED7, MPPE1, GP1BB, SH2B2, SLC25A40, PTPRD, SLC12A2, NF2, OR2B11, OR11L1, ARMC10, ANKAR, CYP20A1, GDPD3, JAK2, SP9, MUC17 1027 6256 19235 1.1166931157967612 0.9411009872146483 0.269962221179183 7.163115396266939 UP_SEQ_FEATURE transmembrane region 288 25.71428571428571 0.04142590756036592 CYP3A4, FAM200A, CDIPT, VAPA, SCN3A, PVRIG, MEGF10, CDH20, FAM171B, PRRT2, PPAPDC2, CHRNA7, SCD5, NPSR1, CHRNA1, MUC12, GJD2, SLC12A6, TMEFF2, SLC12A9, PTPRM, ABCB11, PLD5, SCN2A, UBR3, PTPRT, C1ORF101, COLEC12, TMEM200C, PTPRN, PDCD1LG2, LPCAT4, RYR3, SPAG4, MC2R, ASPHD1, CD226, BLCAP, ORAI2, OR13G1, TPST2, ERMP1, KIAA1109, SCN1A, CLCN3, C16ORF92, OR2T2, CYP51A1, OR2T1, CHKB, OR2T4, OR2T3, TMX3, NPY6R, EPHB4, GPR141, SLC32A1, TMEM129, OR2T5, OR2T6, OR2T8, OR2C3, GPR155, TRPC3, MLC1, TAOK2, PCDH10, TRPC7, AFG3L2, DAGLB, TMEM191B, SEMA6A, EPHA4, GTSCR1, TMEM191A, CNIH3, CNIH4, ALG12, GJA8, STEAP4, ORMDL1, GLRA3, APCDD1, GJA5, FAM57B, DNAJC18, SLC23A1, TNFRSF11A, SLC23A3, XYLT1, AGPAT9, TICAM2, MC5R, SLC25A1, KCNG2, KDELR2, KIAA1324L, ZDHHC4, ZDHHC8, PGAP1, CLIC2, CYB5A, OR2W5, OR2AE1, OR2W3, RHBDD3, SLC26A5, AQPEP, CHSY3, PSEN2, CYBRD1, SLC27A6, MOSPD3, SUSD4, SGCE, STEAP2, STEAP1, DEGS1, MFSD6, OR1C1, MFSD8, OR6F1, SLC39A10, TFR2, BET1, CTXN3, CLDN12, GJC3, CLDN15, NETO1, OR2G3, OR2G2, KIAA1432, GPM6A, OR2G6, DISP1, LRRTM2, BCL2, C1ORF95, MANBAL, ACSL6, MOGAT3, CPT1B, CNST, FZD1, CYP4V2, KCNV2, FZD7, MARCH3, CDH19, KREMEN1, MC4R, ABCC1, C4ORF3, LRP2, ABCC6, VLDLR, QRFPR, OR2AK2, ZAN, TLR3, ROMO1, TLR5, GPR89B, SEZ6L2, AQP12A, AQP12B, GALR1, ADIG, PGRMC2, RPN2, BRI3, SLC4A3, PQLC1, OR14C36, ATG9A, PLXNB2, PKD2L2, CBLN2, SLC25A31, ATP9B, CHPF, UPK3BL, KDSR, SLC40A1, OR2L8, GAL3ST4, OR2L5, FGFR3, PANX2, TMEM63A, BMPR2, TMEM219, SLC38A11, LMAN1, OR2L3, OR2L13, CASD1, OR2L2, G6PC2, FIS1, KIAA1024L, MIA3, ITGAV, LMTK2, OR2T33, SCN9A, OR2T35, MFAP3L, OR2T34, TMEM198, OR2M7, NOMO3, ADAM29, SEC11C, EPHX1, ABCB1, OR2M2, REEP2, HERPUD2, ABCB6, OR2M3, OR2M4, OR2M5, ABCB4, SLC25A12, OR14A16, GPR35, P2RX6, OR2T29, ITGA6, OR2T27, CD274, ECSCR, SPCS3, ADAM22, NAT8L, CLDN5, DPY19L1, TMEM173, DGCR2, OR2T10, OR2T11, OR2T12, VN1R5, DSEL, GALNTL6, ATP8B1, SCN7A, CALCRL, DCAF17, LBR, SLC1A1, MLANA, PILRB, CCDC108, PILRA, HEPACAM2, PIGN, MUC3A, COQ2, CHRM5, FAM134A, DPY19L2P1, OR14I1, MFSD10, C16ORF54, CUX1, GALNT3, NDUFB3, CALCR, TMEM194B, GALNT7, LMF2, COMT, ATP5G3, SCARF2, TMED7, MPPE1, GP1BB, SLC25A40, PTPRD, SLC12A2, OR2B11, OR11L1, ARMC10, ANKAR, CYP20A1, GDPD3, SP9, MUC17 1024 4911 19113 1.094589951130116 1.0 0.9999988382921626 52.724091385907116 SP_PIR_KEYWORDS transmembrane 290 25.892857142857146 0.04494723743106686 CYP3A4, FAM200A, CDIPT, VAPA, SCN3A, PVRIG, MEGF10, CDH20, FAM171B, PRRT2, PPAPDC2, CHRNA7, SCD5, NPSR1, CHRNA1, MUC12, GJD2, SLC12A6, TMEFF2, SLC12A9, PTPRM, ABCB11, PLD5, SCN2A, UBR3, PTPRT, C1ORF101, COLEC12, TMEM200C, PTPRN, PDCD1LG2, LPCAT4, RYR3, SPAG4, MC2R, ASPHD1, CD226, BLCAP, ORAI2, OR13G1, TPST2, ERMP1, KIAA1109, SCN1A, CLCN3, C16ORF92, OR2T2, CYP51A1, OR2T1, CHKB, OR2T4, OR2T3, TMX3, NPY6R, EPHB4, GPR141, SLC32A1, TMEM129, OR2T5, OR2T6, OR2T8, OR2C3, GPR155, TRPC3, MLC1, TAOK2, PCDH10, TRPC7, AFG3L2, DAGLB, TMEM191B, SEMA6A, EPHA4, GTSCR1, TMEM191A, CNIH3, CNIH4, ALG12, GJA8, STEAP4, ORMDL1, GLRA3, APCDD1, GJA5, FAM57B, DNAJC18, SLC23A1, TNFRSF11A, SLC23A3, XYLT1, AGPAT9, TICAM2, MC5R, SLC25A1, KCNG2, FBXL18, KDELR2, KIAA1324L, ZDHHC4, ZDHHC8, PGAP1, CLIC2, CYB5A, OR2W5, OR2AE1, OR2W3, RHBDD3, SLC26A5, AQPEP, CHSY3, PSEN2, CYBRD1, SLC27A6, MOSPD3, SUSD4, SGCE, STEAP2, STEAP1, DEGS1, MFSD6, OR1C1, MFSD8, OR6F1, SLC39A10, TFR2, BET1, CTXN3, CLDN12, GJC3, CLDN15, NETO1, OR2G3, FMO5, OR2G2, KIAA1432, GPM6A, OR2G6, DISP1, LRRTM2, BCL2, C1ORF95, MANBAL, ACSL6, MOGAT3, CPT1B, CNST, FZD1, CYP4V2, KCNV2, FZD7, MARCH3, CDH19, KREMEN1, MC4R, ABCC1, C4ORF3, LRP2, ABCC6, VLDLR, QRFPR, OR2AK2, ZAN, TLR3, ROMO1, TLR5, GPR89B, SEZ6L2, AQP12A, AQP12B, GALR1, ADIG, PGRMC2, RPN2, BRI3, SLC4A3, PQLC1, OR14C36, ATG9A, PLXNB2, PKD2L2, CBLN2, SLC25A31, ATP9B, CHPF, UPK3BL, KDSR, SLC40A1, OR2L8, GAL3ST4, OR2L5, FGFR3, PANX2, TMEM63A, BMPR2, TMEM219, SLC38A11, LMAN1, OR2L3, OR2L13, CASD1, OR2L2, G6PC2, FIS1, KIAA1024L, MIA3, ITGAV, LMTK2, OR2T33, SCN9A, OR2T35, MFAP3L, OR2T34, TMEM198, OR2M7, NOMO3, ADAM29, SEC11C, EPHX1, ABCB1, OR2M2, REEP2, HERPUD2, ABCB6, OR2M3, OR2M4, OR2M5, ABCB4, SLC25A12, OR14A16, GPR35, P2RX6, OR2T29, ITGA6, OR2T27, CD274, ECSCR, SPCS3, ADAM22, NAT8L, CLDN5, DPY19L1, TMEM173, DGCR2, OR2T10, OR2T11, OR2T12, VN1R5, DSEL, GALNTL6, ATP8B1, SCN7A, CALCRL, DCAF17, LBR, SLC1A1, MLANA, PILRB, CCDC108, PILRA, HEPACAM2, PIGN, MUC3A, COQ2, CHRM5, FAM134A, DPY19L2P1, OR14I1, MFSD10, C16ORF54, CUX1, GALNT3, NDUFB3, CALCR, GALNT7, TMEM194B, LMF2, COMT, ATP5G3, SCARF2, TMED7, MPPE1, GP1BB, SLC25A40, PTPRD, SLC12A2, OR2B11, OR11L1, ARMC10, ANKAR, CYP20A1, GDPD3, SP9, MUC17 1027 4973 19235 1.0921977705902035 0.9999999999924969 0.6127673748393921 48.946872322309 SP_PIR_KEYWORDS receptor 99 8.839285714285715 0.0653867805237546 QRFPR, OR2AK2, TLR3, TLR5, SEZ6L2, GALR1, PGRMC2, CHRNA7, NPSR1, CHRNA1, OR14C36, PTPRM, PLXNB2, COLEC12, PTPRT, PTPRN, PDCD1LG2, RYR3, MC2R, CD226, OR13G1, OR2L8, OR2L5, FGFR3, OR2T2, OR2T1, OR2T4, OR2T3, BMPR2, NPY6R, OR2L3, EPHB4, GPR141, OR2L13, OR2L2, ITGAV, OR2T33, OR2T5, OR2T6, OR2T35, OR2T8, OR2T34, OR2C3, OR2M7, TRPC3, PTPN2, TRPC7, OR2M2, OR2M3, OR2M4, OR2M5, GNGT1, OR14A16, EPHA4, GPR35, OR2T29, P2RX6, ITGA6, OR2T27, CD274, ADAM22, GLRA3, DGCR2, TNFRSF11A, OR2T10, OR2T11, VN1R5, OR2T12, MC5R, CALCRL, LBR, PILRB, PILRA, FBXL18, KDELR2, OR2W5, NLRP3, OR2W3, OR2AE1, CHRM5, OR14I1, CALCR, OR1C1, OR6F1, TFR2, NETO1, SCARF2, OR2G3, OR2G2, OR2G6, PTPRD, OR2B11, OR11L1, FZD1, RTN4R, FZD7, MC4R, LRP2, VLDLR, GFRA3 1027 1583 19235 1.171321262119858 1.0 0.6590992343744109 62.78899350994318 GOTERM_CC_FAT GO:0005886~plasma membrane 228 20.357142857142858 0.09068430924669921 CDIPT, SEC31A, VAPA, SCN3A, MEGF10, CDH20, TRAK2, SERPINE1, RAPGEF6, CHRNA7, NPSR1, CHRNA1, MUC12, GJD2, SLC12A6, SLC12A9, PTPRM, ABCB11, SCN2A, F8, PTPRT, CTNNA1, PTPRN, PDCD1LG2, DOC2A, MC2R, TFPI, CD226, ADD1, OR13G1, SCN1A, CLCN3, OR2T2, OR2T1, OR2T4, OR2T3, NPY6R, EPHB4, GPR141, RAC1, POTEC, OR2T5, OBSL1, OR2T6, OR2T8, OR2C3, TRPC3, PCDH10, DAGLB, EPHA4, GNGT1, CLTCL1, GJA8, STEAP4, AP1B1, GLRA3, AP3S1, GJA5, AP1S1, SLC23A1, MAPT, TICAM2, MC5R, IHH, KCNG2, AIFM3, CYB5A, OR2W5, RFTN2, OR2W3, OR2AE1, LRPAP1, ELMO1, FMN1, GNAL, EPB41L3, EPB41L1, SLC26A5, PSEN2, DOK7, NAB1, CYBRD1, SLC27A6, SGCE, STEAP2, STEAP1, DEGS1, SNAP29, OR1C1, OR6F1, TFR2, ABI2, GNG11, CLDN12, GJC3, NETO1, CLDN15, OR2G3, OR2G2, OR2G6, RASA4, ACSL6, DLGAP1, RTN4R, CRIPAK, CAPN2, KCNV2, RAPH1, FZD7, RAB31, CDH19, ARSA, MC4R, ABCC1, LRP2, GFRA3, ABCC6, VLDLR, QRFPR, SEPT5, OR2AK2, ENAH, MAEA, ZAN, TLR3, TLR5, AZGP1, SEZ6L2, GALR1, SLC4A3, OR14C36, GNB1L, COL1A2, SLC40A1, SRI, OR2L8, BBS5, OR2L5, ACHE, FGFR3, BBS7, PANX2, BBS9, BMPR2, NOSTRIN, OR2L3, OR2L13, SRC, OR2L2, AZGP1P1, PPP1R16B, ITGAV, OR2T33, SCN9A, GRID2IP, OR2T35, MFAP3L, OR2T34, EWSR1, OR2M7, ADAM29, FSCN1, ABCB1, OR2M2, OR2M3, OR2M4, SHANK3, OR2M5, ABCB4, OR14A16, GPR35, OR2T29, P2RX6, PLCG1, ITGA6, OR2T27, CDC42SE2, CD274, ECSCR, KCTD18, HSPD1, FABP2, TRIP6, KCTD13, CLDN5, MBP, TMEM173, GPC2, DES, OR2T10, OR2T11, OR2T12, VN1R5, SDPR, RASL10A, CASP8, ATP8B1, CALCRL, SCN7A, GPC1, SLC1A1, MLANA, PILRB, PILRA, RAB39B, SLA2, INHA, BPI, MUC3A, CHRM5, CAPN10, XIRP2, OR14I1, CALCR, CPLX4, TAC1, COMT, MYOT, TMED7, GP1BB, TGM2, SH2B2, SCLT1, PTPRD, NF2, SLC12A2, OR2B11, OR11L1, PPP1R9A, JAK2, MUC17 713 3777 12782 1.0821741247032586 1.0 0.7306836902345817 74.39254502017708 SP_PIR_KEYWORDS glycoprotein 248 22.142857142857142 0.10957099224665849 GLB1L, SCN3A, MEGF10, CDH20, FAM171B, TRAK2, PRRT2, PLOD3, SERPINE1, CCBE1, CHRNA7, NPSR1, CHRNA1, MUC12, F11, SLC12A6, TMEFF2, WNT10A, SLC12A9, PTPRM, ABCB11, PLD5, SCN2A, F8, PTPRT, C1ORF101, COLEC12, PTPRN, PDCD1LG2, LPCAT4, VEGFC, RYR3, MC2R, TFPI, CD226, OR13G1, TPST2, ERMP1, SCN1A, CLCN3, CRELD2, OR2T2, OR2T1, DNAH14, OR2T4, TMX3, OR2T3, NPY6R, EPHB4, GPR141, SLC32A1, TMEM129, KLKB1, OR2T5, OR2T6, OR2T8, OR2C3, GPR155, PCDH10, TRPC7, MSTN, EMILIN2, EMILIN3, LAMA1, EPHA4, SEMA6A, SFRP4, STEAP4, GLRA3, APCDD1, SLC23A1, TNFRSF11A, P4HA2, XYLT1, SCRG1, MAPT, TICAM2, MC5R, IHH, KIAA1324L, PGAP1, OR2W5, OR2W3, OR2AE1, LRPAP1, SLC26A5, AQPEP, CHSY3, SERPINB5, SERPINB2, CYBRD1, SIL1, C4ORF29, SUSD4, SGCE, SERPINB4, SERPINB3, CSF2, OR6F1, EPDR1, SLC39A10, TFR2, COL3A1, PCOLCE, NETO1, OR2G3, OR2G2, GPM6A, OR2G6, DISP1, LRRTM2, HGFAC, WNT8A, MOGAT3, IL3, CNST, FZD1, RTN4R, KCNV2, FZD7, CDH19, KREMEN1, ARSA, MC4R, ABCC1, SERPIND1, LRP2, IL2, GFRA3, ABCC6, VLDLR, QRFPR, OR2AK2, CNDP1, ZAN, TLR3, TLR5, AGXT, AZGP1, SEZ6L2, GPR89B, GALR1, RPN2, LOX, WNT6, SPON2, TFPI2, OR14C36, HHIPL2, PLXNB2, IL21, PKD2L2, C2ORF69, CHPF, UPK3BL, COL1A2, RELN, SLC40A1, OR2L8, TWSG1, GAL3ST4, OR2L5, ACHE, FGFR3, PANX2, TMEM63A, BMPR2, TMEM219, SLC38A11, GREM1, OR2L3, OR2L13, G6PC2, OR2L2, AZGP1P1, MIA3, ITGAV, OR2T33, SCN9A, LMTK2, OR2T35, MFAP3L, OR2T34, OR2M7, NOMO3, ADAM29, ABCB1, OR2M2, OR2M3, OR2M4, OR2M5, ABCB4, OR14A16, GPR35, P2RX6, OR2T29, ITGA6, OR2T27, CD274, ECSCR, SPCS3, ADAM22, HMSD, GPC2, DGCR2, OR2T10, OR2T11, HPSE, OR2T12, VN1R5, EMID1, AOAH, DSEL, GALNTL6, CLUL1, SCN7A, CALCRL, LBP, GPC1, SLC1A1, PILRB, PILRA, HEPACAM2, INHA, LEFTY1, PIGN, BPI, MUC3A, CHRM5, OR14I1, GALNT3, CALCR, FKBP9, ADAMTS19, LMF2, SPOCK1, SCARF2, TMED7, GP1BB, NPTX2, LEFTY2, EPO, PTPRD, NF2, SLC12A2, OR2B11, OR11L1, COL5A2, BMPER, SP9, MUC17 1027 4318 19235 1.075699061874096 1.0 0.7398990888997288 81.66850131372323 GOTERM_CC_FAT GO:0031224~intrinsic to membrane 320 28.57142857142857 0.1561597454095162 CYP3A4, FAM200A, CDIPT, SCN3A, VAPA, PVRIG, MEGF10, CDH20, FAM171B, PRRT2, PPAPDC2, CHRNA7, SCD5, NPSR1, CHRNA1, MUC12, GJD2, SLC12A6, TMEFF2, SLC12A9, PTPRM, ABCB11, PLD5, SCN2A, UBR3, PTPRT, C1ORF101, COLEC12, TMEM200C, PTPRN, PDCD1LG2, LPCAT4, MAD2L1, RYR3, SPAG4, FER1L4, MC2R, ASPHD1, RAB12, CD226, BLCAP, ORAI2, OR13G1, TPST2, ERMP1, KIAA1109, SCN1A, CLCN3, C16ORF92, OR2T2, CYP51A1, OR2T1, CHKB, OR2T4, OR2T3, TMX3, AHCTF1, NPY6R, EPHB4, GPR141, SLC32A1, TMEM129, GORASP2, OR2T5, OR2T6, OR2T8, OR2C3, GPR155, TRPC3, MLC1, TMCO5B, TAOK2, PCDH10, TRPC7, AFG3L2, DAGLB, TMEM191B, SEMA6A, EPHA4, GTSCR1, TMEM191A, CNIH3, CNIH4, ALG12, GJA8, STEAP4, ORMDL1, GLRA3, APCDD1, GJA5, FAM57B, DNAJC18, SLC23A1, MAP1LC3C, TNFRSF11A, SLC23A3, SEH1L, XYLT1, AGPAT9, TICAM2, MC5R, SLC25A1, KCNG2, FBXL18, KDELR2, KIAA1324L, ZDHHC4, ZDHHC8, PGAP1, CLIC2, CYB5A, OR2W5, RFTN2, OR2AE1, OR2W3, RHBDD3, LRPAP1, SLC26A5, AQPEP, CHSY3, PSEN2, CYBRD1, SLC27A6, MOSPD3, SUSD4, SGCE, STEAP2, STEAP1, DEGS1, MFSD6, OR1C1, MFSD8, OR6F1, SLC39A10, TFR2, BET1, CTXN3, CLDN12, GJC3, CLDN15, NETO1, OR2G3, FMO5, OR2G2, KIAA1432, SUMO1, GPM6A, OR2G6, DISP1, LRRTM2, BCL2, C1ORF95, MANBAL, ACSL6, MOGAT3, CPT1B, CNST, RTN4R, FZD1, CYP4V2, TECPR1, KCNV2, FZD7, MARCH3, KREMEN1, CDH19, MC4R, ABCC1, C4ORF3, LRP2, VLDLR, ABCC6, GFRA3, QRFPR, OR2AK2, MAEA, ZAN, TLR3, ROMO1, TLR5, GPR89B, SEZ6L2, AQP12A, AQP12B, GALR1, ADIG, PGRMC2, RPN2, BRI3, SLC4A3, PQLC1, OR14C36, ATG9A, PLXNB2, PKD2L2, CBLN2, SLC25A31, ATP9B, CHPF, UPK3BL, KDSR, SLC40A1, MVP, STK16, OR2L8, ACHE, GAL3ST4, OR2L5, FGFR3, PANX2, TMEM63A, BMPR2, TMEM219, SLC38A11, LMAN1, OR2L3, OR2L13, CASD1, OR2L2, G6PC2, FIS1, KIAA1024L, MIA3, PPP1R16B, ITGAV, LMTK2, OR2T33, SCN9A, OR2T35, MFAP3L, OR2T34, TMEM198, OR2M7, NOMO3, ADAM29, SEC11C, EPHX1, ABCB1, OR2M2, REEP2, HERPUD2, ABCB6, OR2M3, OR2M4, OR2M5, ABCB4, SLC25A12, OR14A16, GPR35, P2RX6, OR2T29, ITGA6, OR2T27, CDC42SE2, CD274, ECSCR, SPCS3, KCTD18, ADAM22, HSPD1, TRIP6, KCTD13, NAT8L, CLDN5, DPY19L1, TMEM173, GPC2, DGCR2, OR2T10, OR2T11, OR2T12, VN1R5, DSEL, GALNTL6, ATP8B1, SCN7A, CALCRL, GPC1, DCAF17, LBR, SLC1A1, MLANA, PILRB, CCDC108, PILRA, DHRS9, HEPACAM2, PIGN, BPI, MUC3A, COQ2, CHRM5, FAM134A, SBF1, DPY19L2P1, OR14I1, MFSD10, C16ORF54, CUX1, GALNT3, NDUFB3, CALCR, CPLX4, GALNT7, TMEM194B, LMF2, COMT, ATP5G3, SCARF2, TMED7, MPPE1, GP1BB, SLC25A40, PTPRD, SLC12A2, OR2B11, OR11L1, ARMC10, ANKAR, CYP20A1, GDPD3, SP9, MUC17 713 5485 12782 1.0458818580829266 1.0 0.8449261624905775 91.22428725362276 UP_SEQ_FEATURE glycosylation site:N-linked (GlcNAc...) 235 20.982142857142858 0.1667329349245238 GLB1L, SCN3A, MEGF10, CDH20, FAM171B, PRRT2, PLOD3, SERPINE1, CCBE1, CHRNA7, NPSR1, CHRNA1, MUC12, F11, SLC12A6, TMEFF2, WNT10A, SLC12A9, PTPRM, ABCB11, PLD5, SCN2A, F8, PTPRT, COLEC12, C1ORF101, PTPRN, PDCD1LG2, LPCAT4, VEGFC, RYR3, MC2R, TFPI, CD226, OR13G1, TPST2, ERMP1, SCN1A, CLCN3, CRELD2, OR2T2, OR2T1, DNAH14, OR2T4, TMX3, OR2T3, NPY6R, EPHB4, GPR141, SLC32A1, TMEM129, KLKB1, OR2T5, OR2T6, OR2T8, OR2C3, GPR155, PCDH10, TRPC7, MSTN, EMILIN2, EMILIN3, LAMA1, EPHA4, SEMA6A, SFRP4, STEAP4, GLRA3, APCDD1, SLC23A1, TNFRSF11A, P4HA2, XYLT1, SCRG1, TICAM2, MC5R, IHH, KIAA1324L, PGAP1, OR2W5, OR2W3, OR2AE1, LRPAP1, SLC26A5, AQPEP, CHSY3, SERPINB5, SERPINB2, CYBRD1, SIL1, C4ORF29, SUSD4, SGCE, CSF2, OR6F1, EPDR1, SLC39A10, TFR2, PCOLCE, NETO1, OR2G3, OR2G2, GPM6A, OR2G6, DISP1, LRRTM2, HGFAC, WNT8A, MOGAT3, IL3, CNST, FZD1, RTN4R, KCNV2, FZD7, CDH19, KREMEN1, ARSA, MC4R, ABCC1, SERPIND1, LRP2, GFRA3, ABCC6, VLDLR, QRFPR, OR2AK2, CNDP1, ZAN, TLR3, TLR5, AZGP1, SEZ6L2, GPR89B, GALR1, RPN2, LOX, WNT6, TFPI2, OR14C36, HHIPL2, PLXNB2, IL21, PKD2L2, C2ORF69, CHPF, UPK3BL, COL1A2, RELN, SLC40A1, OR2L8, TWSG1, GAL3ST4, OR2L5, ACHE, FGFR3, PANX2, TMEM63A, BMPR2, TMEM219, SLC38A11, GREM1, OR2L3, OR2L13, G6PC2, OR2L2, AZGP1P1, MIA3, ITGAV, OR2T33, SCN9A, LMTK2, OR2T35, MFAP3L, OR2T34, OR2M7, NOMO3, ADAM29, ABCB1, OR2M2, OR2M3, OR2M4, OR2M5, ABCB4, OR14A16, GPR35, P2RX6, OR2T29, ITGA6, OR2T27, CD274, SPCS3, ADAM22, HMSD, DGCR2, OR2T10, OR2T11, HPSE, OR2T12, VN1R5, EMID1, AOAH, DSEL, GALNTL6, CLUL1, SCN7A, CALCRL, LBP, GPC1, SLC1A1, PILRB, PILRA, HEPACAM2, INHA, LEFTY1, PIGN, BPI, CHRM5, OR14I1, CALCR, GALNT3, FKBP9, ADAMTS19, LMF2, SCARF2, TMED7, GP1BB, NPTX2, LEFTY2, EPO, PTPRD, SLC12A2, OR2B11, OR11L1, COL5A2, BMPER, SP9, MUC17 1024 4129 19113 1.062311499076653 1.0 0.9999923676127783 96.0436055557022 GOTERM_CC_FAT GO:0016021~integral to membrane 308 27.500000000000004 0.1851405693605618 CYP3A4, FAM200A, CDIPT, VAPA, SCN3A, PVRIG, MEGF10, CDH20, FAM171B, PRRT2, PPAPDC2, CHRNA7, SCD5, NPSR1, CHRNA1, MUC12, GJD2, SLC12A6, TMEFF2, SLC12A9, PTPRM, ABCB11, PLD5, SCN2A, UBR3, PTPRT, C1ORF101, COLEC12, TMEM200C, PTPRN, PDCD1LG2, LPCAT4, MAD2L1, RYR3, SPAG4, FER1L4, MC2R, ASPHD1, CD226, BLCAP, ORAI2, OR13G1, TPST2, ERMP1, KIAA1109, SCN1A, CLCN3, C16ORF92, OR2T2, CYP51A1, OR2T1, CHKB, OR2T4, OR2T3, TMX3, AHCTF1, NPY6R, EPHB4, GPR141, SLC32A1, TMEM129, OR2T5, OR2T6, OR2T8, OR2C3, GPR155, TRPC3, MLC1, TMCO5B, TAOK2, PCDH10, TRPC7, AFG3L2, DAGLB, TMEM191B, SEMA6A, EPHA4, GTSCR1, TMEM191A, CNIH3, CNIH4, ALG12, GJA8, STEAP4, ORMDL1, GLRA3, APCDD1, GJA5, FAM57B, DNAJC18, SLC23A1, TNFRSF11A, SLC23A3, SEH1L, XYLT1, AGPAT9, TICAM2, MC5R, SLC25A1, KCNG2, FBXL18, KDELR2, KIAA1324L, ZDHHC4, ZDHHC8, PGAP1, CLIC2, CYB5A, OR2W5, OR2AE1, OR2W3, RHBDD3, LRPAP1, SLC26A5, AQPEP, CHSY3, PSEN2, CYBRD1, SLC27A6, MOSPD3, SUSD4, SGCE, STEAP2, STEAP1, DEGS1, MFSD6, OR1C1, MFSD8, OR6F1, SLC39A10, TFR2, BET1, CTXN3, CLDN12, GJC3, CLDN15, NETO1, OR2G3, FMO5, OR2G2, KIAA1432, SUMO1, GPM6A, OR2G6, DISP1, LRRTM2, BCL2, C1ORF95, MANBAL, ACSL6, MOGAT3, CPT1B, CNST, FZD1, CYP4V2, TECPR1, KCNV2, FZD7, MARCH3, CDH19, KREMEN1, MC4R, ABCC1, C4ORF3, LRP2, VLDLR, ABCC6, QRFPR, OR2AK2, MAEA, ZAN, TLR3, ROMO1, TLR5, GPR89B, SEZ6L2, AQP12A, AQP12B, GALR1, ADIG, PGRMC2, RPN2, BRI3, SLC4A3, PQLC1, OR14C36, ATG9A, PLXNB2, PKD2L2, CBLN2, SLC25A31, ATP9B, CHPF, UPK3BL, KDSR, SLC40A1, MVP, OR2L8, GAL3ST4, OR2L5, FGFR3, PANX2, TMEM63A, BMPR2, TMEM219, SLC38A11, LMAN1, OR2L3, OR2L13, CASD1, OR2L2, G6PC2, FIS1, KIAA1024L, MIA3, ITGAV, LMTK2, OR2T33, SCN9A, OR2T35, MFAP3L, OR2T34, TMEM198, OR2M7, NOMO3, ADAM29, SEC11C, EPHX1, ABCB1, OR2M2, REEP2, HERPUD2, ABCB6, OR2M3, OR2M4, OR2M5, ABCB4, SLC25A12, OR14A16, GPR35, P2RX6, OR2T29, ITGA6, OR2T27, CD274, ECSCR, SPCS3, KCTD18, ADAM22, HSPD1, TRIP6, KCTD13, NAT8L, CLDN5, DPY19L1, TMEM173, DGCR2, OR2T10, OR2T11, OR2T12, VN1R5, DSEL, GALNTL6, ATP8B1, SCN7A, CALCRL, GPC1, DCAF17, LBR, SLC1A1, MLANA, PILRB, CCDC108, PILRA, DHRS9, HEPACAM2, PIGN, BPI, MUC3A, COQ2, CHRM5, FAM134A, SBF1, DPY19L2P1, OR14I1, MFSD10, C16ORF54, CUX1, GALNT3, NDUFB3, CALCR, GALNT7, TMEM194B, LMF2, COMT, ATP5G3, SCARF2, TMED7, MPPE1, GP1BB, SLC25A40, PTPRD, SLC12A2, OR2B11, OR11L1, ARMC10, ANKAR, CYP20A1, GDPD3, SP9, MUC17 713 5297 12782 1.0423894972438021 1.0 0.8670986374646151 94.68157932373457 UP_SEQ_FEATURE topological domain:Cytoplasmic 183 16.339285714285715 0.4794888086868193 OR2AK2, QRFPR, FAM200A, VAPA, ZAN, TLR3, TLR5, MEGF10, SEZ6L2, CDH20, FAM171B, GALR1, PRRT2, CHRNA7, RPN2, NPSR1, CHRNA1, SLC4A3, OR14C36, MUC12, GJD2, SLC12A6, TMEFF2, SLC12A9, ATG9A, PTPRM, ABCB11, PLXNB2, PTPRT, C1ORF101, COLEC12, PTPRN, PDCD1LG2, PKD2L2, CHPF, ATP9B, RYR3, UPK3BL, MC2R, ASPHD1, KDSR, CD226, OR13G1, OR2L8, ERMP1, TPST2, CLCN3, OR2L5, GAL3ST4, FGFR3, OR2T2, PANX2, OR2T1, CHKB, OR2T4, TMX3, OR2T3, BMPR2, SLC38A11, NPY6R, LMAN1, OR2L3, EPHB4, OR2L13, GPR141, G6PC2, OR2L2, SLC32A1, TMEM129, FIS1, MIA3, ITGAV, OR2T5, OR2T33, OR2T6, OR2T35, OR2T8, MFAP3L, OR2T34, OR2C3, OR2M7, ADAM29, NOMO3, TRPC3, SEC11C, PCDH10, TRPC7, ABCB1, OR2M2, OR2M3, OR2M4, DAGLB, OR2M5, ABCB4, EPHA4, OR14A16, SEMA6A, GPR35, P2RX6, OR2T29, ITGA6, OR2T27, ECSCR, CD274, SPCS3, ADAM22, GJA8, GLRA3, CLDN5, APCDD1, GJA5, TMEM173, DGCR2, TNFRSF11A, SLC23A3, OR2T10, OR2T11, XYLT1, VN1R5, OR2T12, GALNTL6, ATP8B1, TICAM2, MC5R, CALCRL, SLC1A1, MLANA, PILRB, KCNG2, PILRA, KDELR2, KIAA1324L, ZDHHC8, PGAP1, HEPACAM2, OR2W3, OR2AE1, PIGN, CHRM5, AQPEP, SLC26A5, CHSY3, PSEN2, OR14I1, SGCE, SUSD4, CUX1, GALNT3, CALCR, OR1C1, MFSD8, GALNT7, OR6F1, TFR2, BET1, CLDN12, GJC3, NETO1, CLDN15, SCARF2, OR2G3, OR2G2, TMED7, GPM6A, OR2G6, GP1BB, LRRTM2, ACSL6, CPT1B, PTPRD, SLC12A2, OR2B11, OR11L1, FZD1, GDPD3, KCNV2, FZD7, CDH19, KREMEN1, MC4R, ABCC1, LRP2, SP9, MUC17, VLDLR, ABCC6 1024 3374 19113 1.012359854308684 1.0 0.9999995177909167 99.9990477910308 UP_SEQ_FEATURE disulfide bond 148 13.214285714285715 0.6514403808366385 OR2AK2, ZAN, TLR3, MEGF10, AZGP1, SEZ6L2, RLN1, GALR1, RLN2, CCBE1, CHRNA7, NPSR1, SPON2, CHRNA1, TFPI2, MUC12, OR14C36, F11, TMEFF2, PTPRM, F8, COLEC12, PTPRT, IL21, PDCD1LG2, VEGFC, TXNDC2, TFPI, RELN, CD226, OR13G1, OR2L8, ERMP1, OR2L5, ACHE, FGFR3, CRELD2, OR2T2, OR2T1, OR2T4, TMX3, OR2T3, BMPR2, CNPY4, NPY6R, LMAN1, OR2L3, GREM1, OR2L13, OR2L2, AZGP1P1, KLKB1, ITGAV, OR2T5, OR2T33, OR2T6, MTCP1, OR2T35, OR2T8, MFAP3L, OR2T34, OR2C3, OR2M7, ADAM29, MSTN, MALT1, EMILIN2, OR2M2, EMILIN3, OR2M3, OR2M4, OR2M5, GNGT1, OR14A16, SEMA6A, LAMA1, GPR35, OR2T29, ITGA6, OR2T27, CD274, SFRP4, ADM2, ADAM22, INSL4, GLRA3, INSL6, DGCR2, TNFRSF11A, OR2T10, OR2T11, EMID1, AOAH, MAPT, OR2T12, GALNTL6, CLUL1, KIAA1324L, CLIC2, OR2W5, HEPACAM2, INHA, OR2W3, OR2AE1, LEFTY1, BPI, CHRM5, MUC3A, OR14I1, SERPINB2, TXNRD2, SUSD4, GALNT3, CSF2, OR1C1, ADAMTS19, GALNT7, OR6F1, TFR2, COL3A1, SPOCK1, PCOLCE, NETO1, SCARF2, OR2G3, OR2G2, OR2G6, NPTX2, SPEG, LEFTY2, SCG5, MYOM1, HGFAC, EPO, IL3, PTPRD, OR2B11, ALPK2, OR11L1, FZD1, RTN4R, FZD7, KREMEN1, VSTM2L, ARSA, LRP2, MUC17, IL2, VLDLR, TXNL4A 1024 2819 19113 0.9799311036715148 1.0 0.9999999853046981 99.99999921486061 UP_SEQ_FEATURE topological domain:Extracellular 142 12.678571428571427 0.67548348606768 OR2AK2, QRFPR, FAM200A, ZAN, TLR5, MEGF10, SEZ6L2, CDH20, FAM171B, GALR1, PRRT2, CHRNA7, NPSR1, CHRNA1, MUC12, OR14C36, GJD2, TMEFF2, SLC12A9, PTPRM, ABCB11, PLXNB2, COLEC12, C1ORF101, PTPRT, PTPRN, PDCD1LG2, PKD2L2, ATP9B, UPK3BL, MC2R, CD226, OR13G1, OR2L8, ERMP1, OR2L5, FGFR3, OR2T2, OR2T1, PANX2, OR2T4, OR2T3, BMPR2, SLC38A11, NPY6R, OR2L3, EPHB4, OR2L13, GPR141, OR2L2, TMEM129, MIA3, ITGAV, OR2T5, OR2T33, OR2T6, OR2T35, OR2T8, MFAP3L, OR2T34, OR2C3, OR2M7, ADAM29, NOMO3, TRPC3, PCDH10, TRPC7, OR2M2, OR2M3, OR2M4, DAGLB, OR2M5, ABCB4, OR14A16, EPHA4, SEMA6A, GPR35, OR2T29, P2RX6, ITGA6, OR2T27, CD274, ECSCR, ADAM22, GJA8, GLRA3, CLDN5, APCDD1, GJA5, TMEM173, DGCR2, TNFRSF11A, SLC23A3, OR2T10, OR2T11, VN1R5, OR2T12, ATP8B1, MC5R, CALCRL, SLC1A1, PILRB, PILRA, KIAA1324L, HEPACAM2, OR2W3, OR2AE1, CHRM5, SLC26A5, OR14I1, SGCE, SUSD4, CALCR, OR1C1, MFSD8, OR6F1, TFR2, CLDN12, GJC3, NETO1, CLDN15, SCARF2, OR2G3, OR2G2, GPM6A, OR2G6, GP1BB, LRRTM2, PTPRD, OR2B11, OR11L1, FZD1, GDPD3, FZD7, CDH19, KREMEN1, MC4R, ABCC1, LRP2, SP9, MUC17, ABCC6, VLDLR 1024 2719 19113 0.9747832095899228 1.0 0.9999999909709376 99.99999977853439 SP_PIR_KEYWORDS disulfide bond 152 13.571428571428571 0.6849092964965158 OR2AK2, ZAN, TLR3, MEGF10, AZGP1, SEZ6L2, RLN1, GALR1, RLN2, CCBE1, CHRNA7, NPSR1, SPON2, CHRNA1, TFPI2, MUC12, OR14C36, F11, TMEFF2, PTPRM, F8, COLEC12, PTPRT, IL21, PDCD1LG2, VEGFC, EIF2AK1, TXNDC2, TFPI, RELN, CD226, OR13G1, OR2L8, ERMP1, OR2L5, ACHE, FGFR3, CRELD2, OR2T2, OR2T1, OR2T4, TMX3, OR2T3, BMPR2, CNPY4, NPY6R, LMAN1, GREM1, OR2L3, OR2L13, OR2L2, AZGP1P1, KLKB1, ITGAV, OR2T5, OR2T33, OR2T6, MTCP1, OR2T35, OR2T8, MFAP3L, OR2T34, OR2C3, OR2M7, ADAM29, MSTN, MALT1, EMILIN2, OR2M2, EMILIN3, OR2M3, OR2M4, OR2M5, LAMA1, GNGT1, OR14A16, SEMA6A, GPR35, OR2T29, ITGA6, OR2T27, CD274, SFRP4, ADM2, ADAM22, INSL4, GLRA3, INSL6, DGCR2, TNFRSF11A, OR2T10, OR2T11, XYLT1, EMID1, AOAH, MAPT, OR2T12, GALNTL6, CLUL1, KIAA1324L, CLIC2, OR2W5, HEPACAM2, INHA, OR2W3, OR2AE1, LEFTY1, BPI, CHRM5, MUC3A, OR14I1, SERPINB2, TXNRD2, SUSD4, CUX1, GALNT3, CSF2, OR1C1, ADAMTS19, GALNT7, OR6F1, TFR2, COL3A1, SPOCK1, PCOLCE, NETO1, SCARF2, OR2G3, OR2G2, OR2G6, NPTX2, SPEG, GP1BB, LEFTY2, SCG5, MYOM1, HGFAC, EPO, IL3, PTPRD, OR2B11, ALPK2, OR11L1, FZD1, RTN4R, FZD7, KREMEN1, VSTM2L, ARSA, LRP2, MUC17, IL2, VLDLR, TXNL4A 1027 2924 19235 0.9736165927615129 1.0 0.9708262379037632 99.99999534748582 Annotation Cluster 42 Enrichment Score: 0.8440736669280201 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030424~axon 16 1.4285714285714286 0.03182183976674209 SLC12A6, ACTB, ALS2, CALCR, SCN1A, HTT, SCN2A, TAC1, STAT1, MBP, SEMA6A, MAPK1, GHRH, MAPT, NEFH, GAD1 713 159 12782 1.8039817583600166 0.9999998354108892 0.560490285354708 37.087915060018005 GOTERM_CC_FAT GO:0042995~cell projection 44 3.9285714285714284 0.2668951007683302 ALS2, CALCR, BBS5, SCN1A, ENAH, BBS7, DNAH14, BBS9, TAC1, ABI2, CETN1, VGF, DNAH7, MBP, MAPT, RAC1, NEFH, SH2B2, GAD1, ACTB, SLC12A6, PTPRM, NF2, HTT, TTC21B, SCN2A, FSCN1, CDK6, INHA, STAT1, RAPH1, MAPK1, SEMA6A, PPP1R9A, SLC25A31, P2RX6, TXNDC2, GHRH, SPAG4, CYBRD1, RELN, GRK4, FABP2, LRP2 713 697 12782 1.1316944387990204 1.0 0.9074719092761677 98.83108893118859 GOTERM_CC_FAT GO:0043005~neuron projection 22 1.9642857142857142 0.34571093192844693 SLC12A6, CALCR, ACTB, ALS2, SCN1A, HTT, SCN2A, ABI2, TAC1, VGF, STAT1, MBP, MAPK1, SEMA6A, PPP1R9A, P2RX6, GHRH, MAPT, NEFH, GRK4, RELN, GAD1 713 342 12782 1.1532032512323351 1.0 0.9349036501637378 99.77095951178225 Annotation Cluster 43 Enrichment Score: 0.8392790770306573 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0030554~adenyl nucleotide binding 105 9.375 0.03531259299910278 FASTKD1, ZAK, ITPKB, CLK1, TOP1, VPS4B, PMS2, RAPGEF4, TLK1, DHX35, PMS1, ABCB11, MYO3B, OLA1, PIM3, HNRNPU, NVL, NME5, MAPK1, EIF2AK1, ATP9B, MAPK3, CSNK1G3, SMARCA2, KIF26B, STK16, CLCN3, GAL3ST4, FGFR3, DNAH14, CHKB, NEK1, STK17B, BMPR2, EPHB4, SRC, UBE2D2, LMTK2, HSPE1, SMCHD1, TAOK2, MYO1B, AK3, ABCB1, AFG3L2, UBE2L3, ABCB6, ABCB4, EPHA4, PLK4, P2RX6, PSMC2, MYH11, GRK4, HSPD1, KIF22, STEAP4, HELQ, ZNF12, MOV10L1, MCM7, PEX1, ACTR5, ATP8B1, PMS2CL, CDK15, CDK14, AKT3, AIFM3, PI4KA, CDK6, NLRP3, KIF1A, TXNRD2, STEAP2, STEAP1, TOP3B, CETN1, AKAP9, ASNS, DNAH7, FMO5, CHD1L, SPEG, TGM2, MARS2, ACTL6B, CHD6, YES1, ACSL6, HSPA9, PDK1, ACTB, CPT1B, ACTC1, ALPK2, MAPK11, STRADB, MAPK12, AOX1, HSPA4L, JAK2, ABCC1, TSSK2, ABCC6, KIF20A 725 1577 12983 1.1923250169461879 0.9999999999999709 0.9255383729748842 42.746482089809 GOTERM_MF_FAT GO:0001883~purine nucleoside binding 106 9.464285714285714 0.04074523431521979 FASTKD1, ZAK, ITPKB, CLK1, TOP1, VPS4B, PMS2, RAPGEF4, TLK1, DHX35, PMS1, ABCB11, MYO3B, OLA1, PIM3, HNRNPU, NVL, NME5, MAPK1, EIF2AK1, ATP9B, PDE5A, MAPK3, CSNK1G3, SMARCA2, KIF26B, STK16, CLCN3, GAL3ST4, FGFR3, DNAH14, CHKB, NEK1, STK17B, BMPR2, EPHB4, SRC, UBE2D2, LMTK2, HSPE1, SMCHD1, TAOK2, MYO1B, AK3, ABCB1, AFG3L2, UBE2L3, ABCB6, ABCB4, EPHA4, PLK4, P2RX6, PSMC2, MYH11, GRK4, HSPD1, KIF22, STEAP4, HELQ, ZNF12, MOV10L1, MCM7, PEX1, ACTR5, ATP8B1, PMS2CL, CDK15, CDK14, AKT3, AIFM3, PI4KA, CDK6, NLRP3, KIF1A, TXNRD2, STEAP2, STEAP1, TOP3B, CETN1, AKAP9, ASNS, DNAH7, FMO5, CHD1L, SPEG, TGM2, MARS2, ACTL6B, CHD6, YES1, ACSL6, HSPA9, PDK1, ACTB, CPT1B, ACTC1, ALPK2, MAPK11, STRADB, MAPK12, AOX1, HSPA4L, JAK2, ABCC1, TSSK2, ABCC6, KIF20A 725 1601 12983 1.1856365633547998 0.9999999999999998 0.9096801503750632 47.54869359080792 GOTERM_MF_FAT GO:0001882~nucleoside binding 106 9.464285714285714 0.04738265967600515 FASTKD1, ZAK, ITPKB, CLK1, TOP1, VPS4B, PMS2, RAPGEF4, TLK1, DHX35, PMS1, ABCB11, MYO3B, OLA1, PIM3, HNRNPU, NVL, NME5, MAPK1, EIF2AK1, ATP9B, PDE5A, MAPK3, CSNK1G3, SMARCA2, KIF26B, STK16, CLCN3, GAL3ST4, FGFR3, DNAH14, CHKB, NEK1, STK17B, BMPR2, EPHB4, SRC, UBE2D2, LMTK2, HSPE1, SMCHD1, TAOK2, MYO1B, AK3, ABCB1, AFG3L2, UBE2L3, ABCB6, ABCB4, EPHA4, PLK4, P2RX6, PSMC2, MYH11, GRK4, HSPD1, KIF22, STEAP4, HELQ, ZNF12, MOV10L1, MCM7, PEX1, ACTR5, ATP8B1, PMS2CL, CDK15, CDK14, AKT3, AIFM3, PI4KA, CDK6, NLRP3, KIF1A, TXNRD2, STEAP2, STEAP1, TOP3B, CETN1, AKAP9, ASNS, DNAH7, FMO5, CHD1L, SPEG, TGM2, MARS2, ACTL6B, CHD6, YES1, ACSL6, HSPA9, PDK1, ACTB, CPT1B, ACTC1, ALPK2, MAPK11, STRADB, MAPK12, AOX1, HSPA4L, JAK2, ABCC1, TSSK2, ABCC6, KIF20A 725 1612 12983 1.1775459912723538 1.0 0.927948126533925 52.904481993513826 INTERPRO IPR017441:Protein kinase, ATP binding site 34 3.0357142857142856 0.0654601018989366 STK16, FGFR3, ZAK, NEK1, BMPR2, STK17B, AKAP9, CLK1, EPHB4, SRC, SPEG, LMTK2, TLK1, YES1, CDK15, CDK14, AKT3, TAOK2, MYO3B, CDK6, MAPK11, PIM3, STRADB, MAPK1, EPHA4, PLK4, EIF2AK1, MAPK12, MAPK3, TSSK2, JAK2, GRK4, ABCC1, CSNK1G3 920 455 16659 1.3530960344003824 1.0 0.9907069878811502 66.93696253105628 GOTERM_MF_FAT GO:0017076~purine nucleotide binding 122 10.892857142857142 0.07332468892662398 SEPT5, FASTKD1, ZAK, ITPKB, CLK1, TOP1, VPS4B, PMS2, RAPGEF4, TLK1, DHX35, PMS1, ABCB11, MYO3B, OLA1, PIM3, HNRNPU, NVL, NME5, MAPK1, EIF2AK1, ATP9B, PDE5A, MAPK3, TUBA4A, RAB12, TUBA4B, CSNK1G3, SMARCA2, SEPT7, KIF26B, STK16, ADSS, CLCN3, GAL3ST4, FGFR3, DNAH14, NEK1, CHKB, STK17B, BMPR2, EPHB4, SRC, UBE2D2, RAC1, GMPPA, LMTK2, HSPE1, SMCHD1, TAOK2, MYO1B, AK3, ABCB1, DOCK8, AFG3L2, UBE2L3, ABCB6, ABCB4, EPHA4, PLK4, P2RX6, PSMC2, MYH11, GRK4, HSPD1, KIF22, STEAP4, HELQ, GTPBP10, ZNF12, MOV10L1, MCM7, PEX1, ACTR5, RASL10A, ATP8B1, TUBB6, PMS2CL, CDK15, AKT3, CDK14, AIFM3, RAB39B, PI4KA, CDK6, NLRP3, GNAL, KIF1A, TXNRD2, STEAP2, STEAP1, TOP3B, CETN1, AKAP9, ASNS, DNAH7, FMO5, CHD1L, SPEG, TGM2, MARS2, ACTL6B, SCG5, CHD6, YES1, ACSL6, HSPA9, ACTB, PDK1, CPT1B, ACTC1, ALPK2, MAPK11, STRADB, RAB31, MAPK12, AOX1, HSPA4L, TSSK2, JAK2, ABCC1, ABCC6, KIF20A 725 1918 12983 1.1390643989788214 1.0 0.9631607199138825 69.31157089930615 GOTERM_MF_FAT GO:0005524~ATP binding 96 8.571428571428571 0.07499333316066054 FASTKD1, ZAK, ITPKB, CLK1, TOP1, VPS4B, PMS2, TLK1, DHX35, PMS1, ABCB11, MYO3B, OLA1, PIM3, HNRNPU, NVL, NME5, MAPK1, EIF2AK1, ATP9B, MAPK3, CSNK1G3, SMARCA2, KIF26B, STK16, CLCN3, FGFR3, DNAH14, NEK1, CHKB, BMPR2, STK17B, EPHB4, SRC, UBE2D2, LMTK2, HSPE1, SMCHD1, TAOK2, MYO1B, AK3, ABCB1, AFG3L2, UBE2L3, ABCB6, ABCB4, EPHA4, PLK4, P2RX6, PSMC2, MYH11, GRK4, HSPD1, KIF22, HELQ, ZNF12, MOV10L1, MCM7, PEX1, ACTR5, ATP8B1, PMS2CL, CDK15, CDK14, AKT3, PI4KA, CDK6, NLRP3, KIF1A, TOP3B, AKAP9, CETN1, ASNS, DNAH7, CHD1L, SPEG, TGM2, ACTL6B, MARS2, CHD6, YES1, ACSL6, HSPA9, PDK1, ACTB, CPT1B, ACTC1, ALPK2, MAPK11, STRADB, MAPK12, HSPA4L, JAK2, TSSK2, ABCC1, KIF20A, ABCC6 725 1477 12983 1.1639324819648402 1.0 0.9599809770857232 70.15766438583586 GOTERM_MF_FAT GO:0032559~adenyl ribonucleotide binding 97 8.660714285714285 0.07703354251430218 FASTKD1, ZAK, ITPKB, CLK1, TOP1, VPS4B, PMS2, TLK1, RAPGEF4, DHX35, PMS1, ABCB11, MYO3B, OLA1, PIM3, HNRNPU, NVL, NME5, MAPK1, EIF2AK1, ATP9B, MAPK3, CSNK1G3, SMARCA2, KIF26B, STK16, CLCN3, FGFR3, DNAH14, CHKB, NEK1, BMPR2, STK17B, EPHB4, SRC, UBE2D2, LMTK2, HSPE1, SMCHD1, TAOK2, MYO1B, AK3, ABCB1, AFG3L2, UBE2L3, ABCB6, ABCB4, EPHA4, PLK4, P2RX6, PSMC2, MYH11, GRK4, HSPD1, KIF22, HELQ, ZNF12, MOV10L1, MCM7, PEX1, ACTR5, ATP8B1, PMS2CL, CDK15, CDK14, AKT3, PI4KA, CDK6, NLRP3, KIF1A, TOP3B, CETN1, AKAP9, ASNS, DNAH7, CHD1L, SPEG, TGM2, ACTL6B, MARS2, CHD6, YES1, ACSL6, HSPA9, PDK1, ACTB, CPT1B, ACTC1, ALPK2, MAPK11, STRADB, MAPK12, HSPA4L, JAK2, ABCC1, TSSK2, ABCC6, KIF20A 725 1497 12983 1.1603445972404578 1.0 0.951285249805267 71.16250837413163 UP_SEQ_FEATURE active site:Proton acceptor 44 3.9285714285714284 0.10426698245316895 ALDOA, STK16, FGFR3, ZAK, CNDP1, CNDP2, CHKB, NEK1, STK17B, BMPR2, LSS, CLK1, EPHB4, SRC, SPEG, LMTK2, TLK1, HSD17B4, YES1, CDK15, CDK14, AKT3, CPT1B, TAOK2, MYO3B, DHRS9, CDK6, PIM3, MAPK11, MAPK1, EPHA4, PLK4, ALDH7A1, EIF2AK1, MAPK12, MAPK3, TXNRD2, KDSR, TSSK2, JAK2, GRK4, CSNK1G3, HPGD, PMPCB, CROT 1024 658 19113 1.2481181136018236 1.0 0.9999613840810301 85.76982808275008 GOTERM_MF_FAT GO:0000166~nucleotide binding 139 12.410714285714286 0.10774956804084332 SEPT5, FASTKD1, ZAK, TRMT2A, ITPKB, CLK1, TOP1, MIOX, VPS4B, PMS2, RAPGEF4, TLK1, DHX35, PMS1, RBM12, ABCB11, MYO3B, OLA1, PIM3, BOLL, HNRNPU, NVL, NME5, MAPK1, EIF2AK1, ATP9B, MAPK3, PDE5A, TUBA4A, TUBA4B, RAB12, CSNK1G3, SMARCA2, SEPT7, KIF26B, STK16, ADSS, CLCN3, GAL3ST4, FGFR3, DNAH14, NEK1, CHKB, STK17B, BMPR2, EPHB4, SRC, UBE2D2, RAC1, GMPPA, HNRNPD, LMTK2, HSPE1, EWSR1, SMCHD1, TAOK2, MYO1B, AK3, SSB, ABCB1, DOCK8, AFG3L2, UBE2L3, ABCB6, HNRNPA0, ABCB4, EPHA4, PLK4, P2RX6, PSMC2, NDUFV2, MYH11, CPNE1, GRK4, HSPD1, PARP1, KIF22, STEAP4, HELQ, GTPBP10, KIAA0430, ZNF12, MOV10L1, MCM7, PEX1, ACTR5, RASL10A, ATP8B1, TUBB6, PMS2CL, CDK15, AKT3, CDK14, CTBP1, AIFM3, RAB39B, PI4KA, CDK6, NLRP3, GNAL, KIF1A, SLC27A6, TXNRD2, RBM39, STEAP2, STEAP1, MATR3, TOP3B, CETN1, AKAP9, ASNS, DNAH7, TYMS, FMO5, CHD1L, SPEG, TGM2, MARS2, ACTL6B, SCG5, YES1, CHD6, ACSL6, HSPA9, ACTB, PDK1, CPT1B, ACTC1, ALPK2, MAPK11, STRADB, RAB31, MAPK12, AOX1, HSPA4L, TSSK2, JAK2, ABCC1, HPGD, KIF20A, ABCC6 725 2245 12983 1.1087547807388065 1.0 0.9544486932638008 82.94147365587024 SP_PIR_KEYWORDS serine/threonine-protein kinase 27 2.410714285714286 0.11759328947647026 STK16, ZAK, NEK1, BMPR2, STK17B, AKAP9, CLK1, SPEG, LMTK2, TLK1, CDK15, AKT3, CDK14, TAOK2, ALPK2, MYO3B, MAPK11, PIM3, CDK6, MAPK1, PLK4, EIF2AK1, MAPK12, MAPK3, GRK4, TSSK2, CSNK1G3 1027 381 19235 1.3272738424736832 1.0 0.738164044017209 83.9402610407902 SP_PIR_KEYWORDS atp-binding 81 7.232142857142858 0.12670360695992378 KIF22, HELQ, ZAK, MOV10L1, ITPKB, CLK1, TOP1, MCM7, PEX1, VPS4B, ATP8B1, TLK1, DHX35, CDK15, CDK14, AKT3, ABCB11, MYO3B, PI4KA, OLA1, PIM3, CDK6, NLRP3, HNRNPU, NVL, MAPK1, KIF1A, EIF2AK1, ATP9B, MAPK3, CSNK1G3, SMARCA2, TOP3B, KIF26B, STK16, CLCN3, FGFR3, DNAH14, CHKB, NEK1, STK17B, BMPR2, ASNS, AKAP9, DNAH7, EPHB4, SRC, CHD1L, UBE2D2, SPEG, LMTK2, MARS2, YES1, CHD6, ACSL6, HSPA9, ACTB, PDK1, CPT1B, ACTC1, TAOK2, MYO1B, MAPK11, ABCB1, STRADB, UBE2L3, AFG3L2, ABCB6, ABCB4, EPHA4, PLK4, MAPK12, PSMC2, HSPA4L, MYH11, ABCC1, GRK4, JAK2, TSSK2, HSPD1, ABCC6, KIF20A 1027 1326 19235 1.1440980406843284 1.0 0.7464123209501633 86.20095014680021 GOTERM_MF_FAT GO:0032553~ribonucleotide binding 114 10.178571428571429 0.1361894962833584 SEPT5, FASTKD1, ZAK, ITPKB, CLK1, TOP1, VPS4B, PMS2, RAPGEF4, TLK1, DHX35, PMS1, ABCB11, MYO3B, OLA1, PIM3, HNRNPU, NVL, NME5, MAPK1, EIF2AK1, ATP9B, PDE5A, MAPK3, TUBA4A, RAB12, TUBA4B, CSNK1G3, SMARCA2, SEPT7, KIF26B, STK16, ADSS, CLCN3, FGFR3, DNAH14, NEK1, CHKB, STK17B, BMPR2, EPHB4, SRC, UBE2D2, GMPPA, RAC1, LMTK2, HSPE1, SMCHD1, TAOK2, MYO1B, AK3, ABCB1, DOCK8, AFG3L2, UBE2L3, ABCB6, ABCB4, EPHA4, PLK4, P2RX6, PSMC2, MYH11, GRK4, HSPD1, KIF22, HELQ, GTPBP10, ZNF12, MOV10L1, MCM7, PEX1, ACTR5, RASL10A, ATP8B1, TUBB6, PMS2CL, CDK15, CDK14, AKT3, RAB39B, PI4KA, CDK6, NLRP3, GNAL, KIF1A, TOP3B, CETN1, AKAP9, ASNS, DNAH7, CHD1L, SPEG, TGM2, MARS2, ACTL6B, SCG5, CHD6, YES1, ACSL6, HSPA9, ACTB, PDK1, CPT1B, ACTC1, ALPK2, MAPK11, STRADB, RAB31, MAPK12, HSPA4L, JAK2, ABCC1, TSSK2, ABCC6, KIF20A 725 1836 12983 1.1119089474870407 1.0 0.9733930597057028 89.67924103095747 GOTERM_MF_FAT GO:0032555~purine ribonucleotide binding 114 10.178571428571429 0.1361894962833584 SEPT5, FASTKD1, ZAK, ITPKB, CLK1, TOP1, VPS4B, PMS2, RAPGEF4, TLK1, DHX35, PMS1, ABCB11, MYO3B, OLA1, PIM3, HNRNPU, NVL, NME5, MAPK1, EIF2AK1, ATP9B, PDE5A, MAPK3, TUBA4A, RAB12, TUBA4B, CSNK1G3, SMARCA2, SEPT7, KIF26B, STK16, ADSS, CLCN3, FGFR3, DNAH14, NEK1, CHKB, STK17B, BMPR2, EPHB4, SRC, UBE2D2, GMPPA, RAC1, LMTK2, HSPE1, SMCHD1, TAOK2, MYO1B, AK3, ABCB1, DOCK8, AFG3L2, UBE2L3, ABCB6, ABCB4, EPHA4, PLK4, P2RX6, PSMC2, MYH11, GRK4, HSPD1, KIF22, HELQ, GTPBP10, ZNF12, MOV10L1, MCM7, PEX1, ACTR5, RASL10A, ATP8B1, TUBB6, PMS2CL, CDK15, CDK14, AKT3, RAB39B, PI4KA, CDK6, NLRP3, GNAL, KIF1A, TOP3B, CETN1, AKAP9, ASNS, DNAH7, CHD1L, SPEG, TGM2, MARS2, ACTL6B, SCG5, CHD6, YES1, ACSL6, HSPA9, ACTB, PDK1, CPT1B, ACTC1, ALPK2, MAPK11, STRADB, RAB31, MAPK12, HSPA4L, JAK2, ABCC1, TSSK2, ABCC6, KIF20A 725 1836 12983 1.1119089474870407 1.0 0.9733930597057028 89.67924103095747 UP_SEQ_FEATURE binding site:ATP 36 3.214285714285714 0.14638457413877012 STK16, FGFR3, ZAK, CHKB, NEK1, BMPR2, STK17B, ITPKB, CLK1, EPHB4, SRC, SPEG, LMTK2, MARS2, TLK1, YES1, CDK15, CDK14, AKT3, PDK1, CPT1B, TAOK2, MYO3B, CDK6, MAPK11, PIM3, STRADB, MAPK1, EPHA4, PLK4, EIF2AK1, MAPK12, MAPK3, TSSK2, JAK2, GRK4, CSNK1G3 1024 542 19113 1.2397442919741697 1.0 0.9999883545200007 93.9349035180794 INTERPRO IPR008271:Serine/threonine protein kinase, active site 25 2.232142857142857 0.16981532083315204 STK16, ZAK, NEK1, BMPR2, STK17B, AKAP9, CLK1, SPEG, TLK1, CDK15, AKT3, CDK14, TAOK2, MYO3B, MAPK11, PIM3, CDK6, STRADB, MAPK1, EIF2AK1, MAPK12, MAPK3, GRK4, TSSK2, CSNK1G3 920 354 16659 1.2787859248341928 1.0 0.9980994379676137 95.22807776458936 INTERPRO IPR002290:Serine/threonine protein kinase 19 1.6964285714285714 0.1851047916002238 TAOK2, NEK1, MYO3B, STK17B, CDK6, MAPK11, PIM3, CLK1, MAPK1, PLK4, MAPK12, SPEG, MAPK3, GRK4, TLK1, TSSK2, CDK15, CDK14, AKT3 920 259 16659 1.3283573946617424 1.0 0.9974523073769207 96.47856823094408 SP_PIR_KEYWORDS nucleotide-binding 99 8.839285714285715 0.18934844840408 SEPT5, ZAK, ITPKB, CLK1, TOP1, VPS4B, TLK1, RAPGEF4, DHX35, ABCB11, MYO3B, OLA1, PIM3, HNRNPU, NVL, MAPK1, EIF2AK1, ATP9B, PDE5A, MAPK3, TUBA4A, RAB12, TUBA4B, CSNK1G3, SEPT7, SMARCA2, KIF26B, STK16, ADSS, CLCN3, FGFR3, DNAH14, CHKB, NEK1, BMPR2, STK17B, EPHB4, SRC, UBE2D2, GMPPA, RAC1, LMTK2, TAOK2, MYO1B, AK3, ABCB1, UBE2L3, AFG3L2, ABCB6, ABCB4, EPHA4, PLK4, PSMC2, MYH11, GRK4, HSPD1, KIF22, HELQ, GTPBP10, MOV10L1, MCM7, PEX1, RASL10A, ATP8B1, TUBB6, CDK15, CDK14, AKT3, RAB39B, PI4KA, CDK6, NLRP3, GNAL, KIF1A, SLC27A6, TOP3B, AKAP9, ASNS, DNAH7, CHD1L, SPEG, MARS2, CHD6, YES1, ACSL6, HSPA9, PDK1, ACTB, CPT1B, ACTC1, MAPK11, STRADB, RAB31, MAPK12, HSPA4L, ABCC1, JAK2, TSSK2, ABCC6, KIF20A 1027 1686 19235 1.0997636761184668 1.0 0.8073371314009361 95.35208747312791 INTERPRO IPR000719:Protein kinase, core 32 2.857142857142857 0.1894382275795071 STK16, FGFR3, ZAK, NEK1, BMPR2, STK17B, AKAP9, CLK1, EPHB4, SRC, SPEG, LMTK2, TLK1, YES1, CDK15, CDK14, AKT3, TAOK2, MYO3B, CDK6, MAPK11, PIM3, STRADB, MAPK1, PLK4, EIF2AK1, MAPK12, MAPK3, TSSK2, JAK2, GRK4, CSNK1G3 920 476 16659 1.2173182316404823 1.0 0.9971696935564079 96.77251813450223 INTERPRO IPR017442:Serine/threonine protein kinase-related 25 2.232142857142857 0.18989686533097577 STK16, NEK1, BMPR2, STK17B, AKAP9, CLK1, SPEG, TLK1, CDK15, AKT3, CDK14, TAOK2, MYO3B, MAPK11, PIM3, CDK6, STRADB, MAPK1, PLK4, EIF2AK1, MAPK12, MAPK3, GRK4, TSSK2, CSNK1G3 920 359 16659 1.2609755359089256 1.0 0.9968508273621766 96.80224294781968 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 59 5.267857142857143 0.19216326665553302 KIF22, HELQ, ZAK, MOV10L1, ITPKB, CLK1, MCM7, PEX1, VPS4B, TLK1, DHX35, CDK15, CDK14, AKT3, MYO3B, OLA1, PIM3, CDK6, NLRP3, HNRNPU, NVL, MAPK1, KIF1A, EIF2AK1, MAPK3, CSNK1G3, SMARCA2, KIF26B, STK16, CLCN3, FGFR3, DNAH14, CHKB, NEK1, STK17B, BMPR2, DNAH7, EPHB4, SRC, CHD1L, SPEG, LMTK2, CHD6, YES1, PDK1, CPT1B, TAOK2, MAPK11, STRADB, AFG3L2, ABCB6, EPHA4, PLK4, MAPK12, PSMC2, MYH11, JAK2, TSSK2, GRK4, KIF20A 1024 962 19113 1.1447373229599793 1.0 0.9999919689989242 97.71467545194008 GOTERM_MF_FAT GO:0004672~protein kinase activity 40 3.571428571428571 0.19810424932212478 STK16, FASTKD1, FGFR3, ZAK, POLR2J, NEK1, STK17B, BMPR2, AKAP9, CLK1, EPHB4, SRC, SPEG, LMTK2, TLK1, PPP4C, YES1, CDK15, CDK14, AKT3, PDK1, TAOK2, ALPK2, MYO3B, CDK6, MAPK11, PIM3, STRADB, MAPK1, EPHA4, PLK4, CRKL, EIF2AK1, MAPK12, MAPK3, RELN, TSSK2, JAK2, GRK4, CSNK1G3 725 606 12983 1.1820188915443268 1.0 0.98709710862893 96.74418887027785 SMART SM00220:S_TKc 19 1.6964285714285714 0.20999987665607894 TAOK2, NEK1, MYO3B, STK17B, CDK6, MAPK11, PIM3, CLK1, MAPK1, PLK4, MAPK12, SPEG, MAPK3, GRK4, TLK1, TSSK2, CDK15, CDK14, AKT3 513 259 9079 1.2982982982982982 1.0 0.976983751092115 95.50794775054561 UP_SEQ_FEATURE domain:Protein kinase 30 2.6785714285714284 0.23890250064265323 STK16, FGFR3, ZAK, NEK1, BMPR2, STK17B, CLK1, EPHB4, SRC, LMTK2, TLK1, YES1, CDK15, AKT3, CDK14, TAOK2, MYO3B, CDK6, MAPK11, PIM3, STRADB, EPHA4, MAPK1, PLK4, EIF2AK1, MAPK12, MAPK3, GRK4, TSSK2, CSNK1G3 1024 469 19113 1.1939257396055438 1.0 0.999996616887257 99.20453041072179 GOTERM_BP_FAT GO:0006793~phosphorus metabolic process 60 5.357142857142857 0.25172137829214536 IMPA2, ZAK, CLK1, TOP1, CHRNA7, TLK1, CDK15, CDK14, AKT3, CTBP1, PTPRM, MYO3B, PI4KA, PIM3, PTPRT, CDK6, PTPRN, PPM1F, MAPK1, EIF2AK1, SBF1, MAPK3, RELN, CSNK1G3, CTDP1, NDUFB3, INPP1, STK16, FGFR3, NEK1, STK17B, BMPR2, ABI2, AKAP9, ATP5G3, EPHB4, SRC, STAT4, SPEG, BCL2, LMTK2, YES1, PDK1, PTPRD, TAOK2, PTPN2, ALPK2, AK3, MAPK11, STRADB, CDC25C, STAT1, EPHA4, DUSP28, PLK4, MAPK12, NDUFV2, JAK2, TSSK2, GRK4 751 973 13528 1.1107902721003717 1.0 0.9831995422470035 99.43354046852009 GOTERM_BP_FAT GO:0006796~phosphate metabolic process 60 5.357142857142857 0.25172137829214536 IMPA2, ZAK, CLK1, TOP1, CHRNA7, TLK1, CDK15, CDK14, AKT3, CTBP1, PTPRM, MYO3B, PI4KA, PIM3, PTPRT, CDK6, PTPRN, PPM1F, MAPK1, EIF2AK1, SBF1, MAPK3, RELN, CSNK1G3, CTDP1, NDUFB3, INPP1, STK16, FGFR3, NEK1, STK17B, BMPR2, ABI2, AKAP9, ATP5G3, EPHB4, SRC, STAT4, SPEG, BCL2, LMTK2, YES1, PDK1, PTPRD, TAOK2, PTPN2, ALPK2, AK3, MAPK11, STRADB, CDC25C, STAT1, EPHA4, DUSP28, PLK4, MAPK12, NDUFV2, JAK2, TSSK2, GRK4 751 973 13528 1.1107902721003717 1.0 0.9831995422470035 99.43354046852009 GOTERM_BP_FAT GO:0006468~protein amino acid phosphorylation 42 3.75 0.2726737497114933 STK16, FGFR3, ZAK, NEK1, STK17B, BMPR2, ABI2, AKAP9, CLK1, EPHB4, SRC, STAT4, SPEG, BCL2, LMTK2, CHRNA7, TLK1, YES1, CDK15, CDK14, AKT3, PDK1, CTBP1, TAOK2, ALPK2, MYO3B, CDK6, PIM3, MAPK11, STRADB, STAT1, MAPK1, EPHA4, PLK4, EIF2AK1, MAPK12, MAPK3, RELN, TSSK2, JAK2, GRK4, CSNK1G3 751 667 13528 1.1342717456185356 1.0 0.9838926343650902 99.65871505785908 GOTERM_MF_FAT GO:0004674~protein serine/threonine kinase activity 28 2.5 0.29721735220968026 STK16, ZAK, NEK1, BMPR2, STK17B, AKAP9, CLK1, SPEG, LMTK2, TLK1, PPP4C, CDK15, AKT3, CDK14, TAOK2, ALPK2, MYO3B, CDK6, MAPK11, PIM3, MAPK1, PLK4, EIF2AK1, MAPK12, MAPK3, GRK4, TSSK2, CSNK1G3 725 430 12983 1.166075380914194 1.0 0.9902773344327559 99.5794096535217 SP_PIR_KEYWORDS kinase 41 3.660714285714286 0.30491906847276623 STK16, CDK5R2, FGFR3, ZAK, CHKB, NEK1, STK17B, BMPR2, AKAP9, ITPKB, CLK1, EPHB4, SRC, SPEG, LMTK2, OBSL1, TLK1, YES1, CDK15, CDK14, AKT3, PDK1, CPT1B, TAOK2, ALPK2, MYO3B, PI4KA, AK3, CDK6, MAPK11, PIM3, MAPK1, EPHA4, PLK4, EIF2AK1, MAPK12, MAPK3, MAPK8IP2, TSSK2, JAK2, GRK4, CSNK1G3 1027 688 19235 1.1161361268993002 1.0 0.8627888984880258 99.50939344265024 SP_PIR_KEYWORDS transferase 79 7.053571428571429 0.3414308162530169 CDIPT, RNMT, ZAK, ITPKB, CLK1, AGXT, XYLT1, AGPAT9, GALNTL6, TFB2M, TLK1, RPN2, CDK15, CDK14, AKT3, POLL, AADAT, METTL8, ZDHHC4, METTL5, METTL4, ZDHHC8, MYO3B, PI4KA, PIM3, CDK6, LPCAT4, PIGN, MAPK1, COQ2, EIF2AK1, CHSY3, CHPF, PRDM6, MAPK3, CSNK1G3, CROT, GALNT3, STK16, TPST2, GAL3ST4, FGFR3, GALNT7, CHKB, NEK1, STK17B, BMPR2, NFS1, HAT1, COMT, EPHB4, CASD1, SRC, TYMS, TYMP, SPEG, GMPPA, LMTK2, TGM2, POLN, YES1, MEPCE, PGGT1B, MOGAT3, PDK1, CPT1B, TAOK2, ALPK2, AK3, SMYD3, MAPK11, EPHA4, PLK4, MAPK12, GRK4, JAK2, TSSK2, PARP1, ALG12, NAT8L 1027 1394 19235 1.0614170621344223 1.0 0.881685890968608 99.77707701458951 GOTERM_BP_FAT GO:0016310~phosphorylation 48 4.285714285714286 0.3530737244906828 NDUFB3, STK16, FGFR3, ZAK, NEK1, STK17B, BMPR2, ABI2, AKAP9, CLK1, EPHB4, ATP5G3, SRC, TOP1, STAT4, SPEG, BCL2, LMTK2, CHRNA7, TLK1, YES1, CDK15, CDK14, AKT3, PDK1, CTBP1, TAOK2, ALPK2, MYO3B, PI4KA, AK3, CDK6, PIM3, MAPK11, STRADB, STAT1, MAPK1, EPHA4, PLK4, EIF2AK1, MAPK12, MAPK3, NDUFV2, RELN, TSSK2, JAK2, GRK4, CSNK1G3 751 800 13528 1.080798934753662 1.0 0.9887623598825649 99.95778491628228 Annotation Cluster 44 Enrichment Score: 0.8271327057757755 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051057~positive regulation of small GTPase mediated signal transduction 5 0.4464285714285714 0.012497282330686458 ALS2, RAC1, ITPKB, RELN, EPO 751 17 13528 5.298033993890499 0.9999999999999992 0.8859293405655736 20.09793319807207 GOTERM_BP_FAT GO:0046579~positive regulation of Ras protein signal transduction 4 0.35714285714285715 0.05539318769295443 ALS2, RAC1, ITPKB, EPO 751 16 13528 4.503328894806924 1.0 0.9673420922982696 63.821100012799306 GOTERM_BP_FAT GO:0051056~regulation of small GTPase mediated signal transduction 13 1.1607142857142858 0.7470777879510302 ALS2, AGFG2, RALBP1, RALGAPB, ITPKB, RAC1, RAPGEF6, RAPGEF4, RELN, SH2B2, RASA4, FBXO8, EPO 751 252 13528 0.9292583433728573 1.0 0.9989829312750539 99.9999999977679 GOTERM_BP_FAT GO:0046578~regulation of Ras protein signal transduction 8 0.7142857142857143 0.9502358547498732 ALS2, RALBP1, AGFG2, RAC1, SH2B2, ITPKB, FBXO8, EPO 751 210 13528 0.6862215458753408 1.0 0.9999944305111258 100.0 Annotation Cluster 45 Enrichment Score: 0.8262885759852701 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS cytoskeleton 50 4.464285714285714 0.006359258075487145 SEPT5, ENAH, MAEA, CEP76, KLHL3, FAM83D, NDE1, MAPT, PPP4C, MYO3B, SPIRE1, CTNNA1, ARPC1A, ARPC1B, EPB41L3, TRIM36, EPB41L1, SPAG4, SGCE, SEPT7, ADD1, HAUS3, SDCCAG8, BBS5, CEP120, DNAH14, BBS9, ABI2, CETN1, AKAP9, NOSTRIN, ANLN, DNAH7, MYOT, TUBGCP6, CEP170, WIPF1, ACTB, ACTC1, NF2, CEP192, TTC21B, PCNT, RAPH1, PLK4, PPP1R9A, ITGA6, CDC42SE2, GAS2L1, TRIP6 1027 636 19235 1.472429926573705 0.9713733538175492 0.29906612857077064 8.904530586876735 GOTERM_CC_FAT GO:0005856~cytoskeleton 89 7.946428571428571 0.09893299943992646 ALS2, SEPT5, KIF22, ENAH, MAEA, VAPA, CEP76, HINT1, PDLIM3, KLHL3, FAM83D, CDC45, MAP1LC3C, NDE1, DES, MAPT, CASP8, TUBB6, RANBP1, PPP4C, MYO3B, SPIRE1, CTNNA1, ELMO1, FMN1, ARPC1A, EPB41L3, MAPK1, ARPC1B, KIF1A, EPB41L1, MAD2L1, TRIM36, KRIT1, SPAG4, MAPK3, TUBA4A, SGCE, TUBA4B, RBM39, SEPT7, DYNC1I2, ADD1, KIF26B, ALDOA, HAUS3, SDCCAG8, BBS5, CEP120, LMNB1, DNAH14, BBS9, STK17B, ABI2, ANLN, NOSTRIN, CETN1, AKAP9, DNAH7, MYOT, MYL9, TUBGCP6, SORBS2, CEP170, NEFH, SH2B2, WIPF1, MYOM1, ACTB, ACTC1, DLGAP1, NF2, MYO1B, CEP192, PCNT, FSCN1, MYL12B, MYOZ2, MYL12A, RAPH1, SHANK3, PPP1R9A, PLK4, P2RX6, CDC42SE2, MYH11, GAS2L1, JAK2, KIF20A 713 1381 12782 1.155328831578231 1.0 0.7339650238240498 77.52743902007703 GOTERM_CC_FAT GO:0044430~cytoskeletal part 57 5.089285714285714 0.35297406660616215 SEPT5, ALS2, KIF22, MAEA, VAPA, CEP76, FAM83D, NDE1, MAP1LC3C, CDC45, DES, MAPT, TUBB6, RANBP1, PPP4C, MYO3B, ARPC1B, KIF1A, MAD2L1, SPAG4, TUBA4A, TUBA4B, SEPT7, DYNC1I2, KIF26B, ADD1, HAUS3, SDCCAG8, BBS5, CEP120, LMNB1, DNAH14, BBS9, CETN1, AKAP9, ANLN, DNAH7, MYL9, TUBGCP6, CEP170, NEFH, SH2B2, WIPF1, MYOM1, DLGAP1, ACTC1, MYO1B, CEP192, PCNT, MYL12B, MYL12A, SHANK3, PPP1R9A, PLK4, P2RX6, MYH11, KIF20A 713 952 12782 1.0733644088771555 1.0 0.9325209571459567 99.80481834406474 GOTERM_CC_FAT GO:0043228~non-membrane-bounded organelle 144 12.857142857142856 0.5768107525546223 ALS2, MRPL40, SEPT5, ENAH, MAEA, VAPA, CEP76, PDLIM3, HIRA, KLHL3, CTNNBL1, TOP1, WDR75, STAG3, TFB2M, PPP4C, SGOL2, MYO3B, SPIRE1, CTNNA1, ZNF3, NVL, ARPC1A, ARPC1B, RCL1, MAPK1, TRIM36, MAD2L1, MRPS18C, SPAG4, PRDM6, MAPK3, PRKRIP1, TUBA4A, TUBA4B, SEPT7, ADD1, KIF26B, ALDOA, HMGB2, BBS5, LMNB1, DNAH14, BBS9, STK17B, AHCTF1, NOSTRIN, ANLN, MYL9, SPC25, CEP170, HNRNPD, SMCHD1, MYO1B, PCNT, FSCN1, SSB, NDC80, MYL12B, MYOZ2, MYL12A, NOP10, SHANK3, NOP14, PLK4, P2RX6, CSRNP3, CDC42SE2, DLX5, MYH11, PARP1, POP7, KIF22, TAF1A, ZNF532, HINT1, GTPBP10, DGCR14, FAM83D, CDC45, NDE1, MAP1LC3C, MCM7, DES, DGCR8, SEH1L, MAPT, CASP8, TUBB6, RANBP1, DCAF17, BRD8, EXOSC9, DSN1, ELMO1, FMN1, EPB41L3, KIF1A, EPB41L1, KRIT1, SGCE, RBM39, LIN54, DYNC1I2, TOP3B, HAUS3, THAP7, SDCCAG8, CEP120, YPEL3, ABI2, CETN1, AKAP9, ZNF655, DNAH7, MYOT, KIAA0020, TUBGCP6, STAT4, RGS12, CIR1, SORBS2, WDR12, NEFH, SH2B2, MYOM1, WIPF1, KDM3B, CHD6, HSPA9, ACTB, DLGAP1, ACTC1, NF2, CEP192, STAT1, RAPH1, PPP1R9A, GAS2L1, NOP58, JAK2, RPL19P12, HPGD, KIF20A 713 2596 12782 0.9944136734257256 1.0 0.9620112237196838 99.99955526091803 GOTERM_CC_FAT GO:0043232~intracellular non-membrane-bounded organelle 144 12.857142857142856 0.5768107525546223 ALS2, MRPL40, SEPT5, ENAH, MAEA, VAPA, CEP76, PDLIM3, HIRA, KLHL3, CTNNBL1, TOP1, WDR75, STAG3, TFB2M, PPP4C, SGOL2, MYO3B, SPIRE1, CTNNA1, ZNF3, NVL, ARPC1A, ARPC1B, RCL1, MAPK1, TRIM36, MAD2L1, MRPS18C, SPAG4, PRDM6, MAPK3, PRKRIP1, TUBA4A, TUBA4B, SEPT7, ADD1, KIF26B, ALDOA, HMGB2, BBS5, LMNB1, DNAH14, BBS9, STK17B, AHCTF1, NOSTRIN, ANLN, MYL9, SPC25, CEP170, HNRNPD, SMCHD1, MYO1B, PCNT, FSCN1, SSB, NDC80, MYL12B, MYOZ2, MYL12A, NOP10, SHANK3, NOP14, PLK4, P2RX6, CSRNP3, CDC42SE2, DLX5, MYH11, PARP1, POP7, KIF22, TAF1A, ZNF532, HINT1, GTPBP10, DGCR14, FAM83D, CDC45, NDE1, MAP1LC3C, MCM7, DES, DGCR8, SEH1L, MAPT, CASP8, TUBB6, RANBP1, DCAF17, BRD8, EXOSC9, DSN1, ELMO1, FMN1, EPB41L3, KIF1A, EPB41L1, KRIT1, SGCE, RBM39, LIN54, DYNC1I2, TOP3B, HAUS3, THAP7, SDCCAG8, CEP120, YPEL3, ABI2, CETN1, AKAP9, ZNF655, DNAH7, MYOT, KIAA0020, TUBGCP6, STAT4, RGS12, CIR1, SORBS2, WDR12, NEFH, SH2B2, MYOM1, WIPF1, KDM3B, CHD6, HSPA9, ACTB, DLGAP1, ACTC1, NF2, CEP192, STAT1, RAPH1, PPP1R9A, GAS2L1, NOP58, JAK2, RPL19P12, HPGD, KIF20A 713 2596 12782 0.9944136734257256 1.0 0.9620112237196838 99.99955526091803 Annotation Cluster 46 Enrichment Score: 0.8236041208815489 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0034464~BBSome 3 0.26785714285714285 0.053982431388143716 BBS5, BBS7, BBS9 713 7 12782 7.683029453015427 0.9999999999977127 0.6726808335631665 54.85321863662334 GOTERM_CC_FAT GO:0060170~cilium membrane 3 0.26785714285714285 0.06937504935608518 BBS5, BBS7, BBS9 713 8 12782 6.7226507713884995 0.9999999999999992 0.6857519856183851 64.31136176550199 SP_PIR_KEYWORDS cilium 8 0.7142857142857143 0.08365820385828039 BBS5, SLC25A31, BBS7, TTC21B, DNAH14, BBS9, SPAG4, DNAH7 1027 71 19235 2.11034463842451 1.0 0.6860864039531978 72.11806513255003 GOTERM_CC_FAT GO:0044441~cilium part 6 0.5357142857142857 0.09618418131063483 BBS5, BBS7, TTC21B, DNAH14, BBS9, DNAH7 713 44 12782 2.4446002805049085 1.0 0.7329053811755937 76.52478737225083 SP_PIR_KEYWORDS Bardet-Biedl syndrome 3 0.26785714285714285 0.1317167744728186 BBS5, BBS7, BBS9 1027 12 19235 4.682327166504382 1.0 0.7545855643610745 87.31477318623966 SP_PIR_KEYWORDS obesity 4 0.35714285714285715 0.21365054066327574 BBS5, BBS7, BBS9, MC4R 1027 30 19235 2.4972411554690037 1.0 0.8242450368851335 97.02137123097255 GOTERM_CC_FAT GO:0031253~cell projection membrane 5 0.4464285714285714 0.49325613132852775 BBS5, BBS7, BBS9, CYBRD1, LRP2 713 65 12782 1.3790052864386664 1.0 0.9587276966733208 99.9941181785035 SP_PIR_KEYWORDS vision 8 0.7142857142857143 0.6161430045504357 BBS5, BBS7, BBS9, MYO3B, RP9, CYP4V2, KCNV2, ABCC6 1027 139 19235 1.077945822504606 1.0 0.9613012003818062 99.9999166277994 Annotation Cluster 47 Enrichment Score: 0.8217453793802323 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006268~DNA unwinding during replication 4 0.35714285714285715 0.039069284627950784 TOP1, HMGB2, MCM7, TOP3B 751 14 13528 5.146661594065056 1.0 0.9530000313210109 50.88547032413779 GOTERM_BP_FAT GO:0032392~DNA geometric change 4 0.35714285714285715 0.0744267744773043 TOP1, HMGB2, MCM7, TOP3B 751 18 13528 4.0029590176061545 1.0 0.9681099967953578 74.83852576136626 GOTERM_BP_FAT GO:0032508~DNA duplex unwinding 4 0.35714285714285715 0.0744267744773043 TOP1, HMGB2, MCM7, TOP3B 751 18 13528 4.0029590176061545 1.0 0.9681099967953578 74.83852576136626 GOTERM_BP_FAT GO:0006261~DNA-dependent DNA replication 5 0.4464285714285714 0.40234939480136184 TOP1, HMGB2, CDC45, MCM7, TOP3B 751 58 13528 1.5528720326920427 1.0 0.9905470804522601 99.98972915722901 GOTERM_CC_FAT GO:0000228~nuclear chromosome 7 0.625 0.8940790028842989 TOP1, HMGB2, MCM7, RGS12, SGOL2, HIRA, STAG3 713 162 12782 0.7746264263328312 1.0 0.9971528350888723 99.99999999999893 Annotation Cluster 48 Enrichment Score: 0.818757119899275 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051656~establishment of organelle localization 8 0.7142857142857143 0.08683753571460659 SEPT5, SNAP29, NDE1, BBS5, BBS7, SEH1L, CDC23, NDC80 751 69 13528 2.088500357011907 1.0 0.9693394869800066 80.22396076646136 GOTERM_BP_FAT GO:0050000~chromosome localization 3 0.26785714285714285 0.20068299549505783 NDE1, SEH1L, CDC23 751 15 13528 3.6026631158455396 1.0 0.9842706217035536 98.16170849218689 GOTERM_BP_FAT GO:0051303~establishment of chromosome localization 3 0.26785714285714285 0.20068299549505783 NDE1, SEH1L, CDC23 751 15 13528 3.6026631158455396 1.0 0.9842706217035536 98.16170849218689 Annotation Cluster 49 Enrichment Score: 0.8110569678534048 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR001357:BRCT 4 0.35714285714285715 0.14369837743039904 POLL, DBF4, PARP1, CTDP1 920 24 16659 3.0179347826086955 1.0 0.9970314710693783 92.0822217992796 SMART SM00292:BRCT 4 0.35714285714285715 0.15055342516468684 POLL, DBF4, PARP1, CTDP1 513 24 9079 2.9496426250812213 1.0 0.9823099824303024 88.32644313874127 UP_SEQ_FEATURE domain:BRCT 3 0.26785714285714285 0.1704851640160386 POLL, PARP1, CTDP1 1024 14 19113 3.999651227678571 1.0 0.999992345055512 96.34748367818815 Annotation Cluster 50 Enrichment Score: 0.7997180295366789 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030099~myeloid cell differentiation 11 0.9821428571428571 0.03294006476363843 CALCR, CSF2, MAEA, SP3, PSEN2, CASP8, JAK2, INHA, SCAND1, ADD1, EPO 751 93 13528 2.130607219048437 1.0 0.9588318925735395 44.98583645320371 GOTERM_BP_FAT GO:0020027~hemoglobin metabolic process 3 0.26785714285714285 0.10281192278861273 INHA, ADD1, EPO 751 10 13528 5.403994673768309 1.0 0.9705564143541067 85.56568310768964 GOTERM_BP_FAT GO:0030218~erythrocyte differentiation 5 0.4464285714285714 0.21392439268920058 MAEA, SP3, INHA, ADD1, EPO 751 43 13528 2.0945715789799646 1.0 0.9839061040231646 98.63547032767866 GOTERM_BP_FAT GO:0034101~erythrocyte homeostasis 5 0.4464285714285714 0.2875514643679107 MAEA, SP3, INHA, ADD1, EPO 751 49 13528 1.8380934264518056 1.0 0.9855538585206268 99.76396257452596 GOTERM_BP_FAT GO:0048872~homeostasis of number of cells 7 0.625 0.4815773259205166 MAEA, BCL2, SP3, SH2B2, INHA, ADD1, EPO 751 100 13528 1.260932090545939 1.0 0.9937083716997132 99.9991877530511 Annotation Cluster 51 Enrichment Score: 0.7943883911933138 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS anticoagulant 4 0.35714285714285715 0.002679769772435266 TFPI, SERPIND1, ANXA5, TFPI2 1027 6 19235 12.486205777345019 0.7756695964684842 0.22050256652846845 3.8468381250394867 SP_PIR_KEYWORDS blood coagulation 8 0.7142857142857143 0.008180629796508753 F11, GP1BB, KLKB1, TFPI, F8, SERPIND1, ANXA5, TFPI2 1027 44 19235 3.4053288483668234 0.9896973181551233 0.3402808098912514 11.315364989070986 GOTERM_BP_FAT GO:0007599~hemostasis 12 1.0714285714285714 0.03688639519954784 F11, GP1BB, KLKB1, HPS4, SERPINE1, COL3A1, TFPI, F8, SERPIND1, LMAN1, ANXA5, TFPI2 751 108 13528 2.0014795088030777 1.0 0.952789527366241 48.856408125704185 GOTERM_BP_FAT GO:0007596~blood coagulation 11 0.9821428571428571 0.05611264402767441 F11, GP1BB, KLKB1, SERPINE1, COL3A1, TFPI, F8, SERPIND1, LMAN1, ANXA5, TFPI2 751 102 13528 1.9426124644265161 1.0 0.9664138915121426 64.30957680018507 GOTERM_BP_FAT GO:0050817~coagulation 11 0.9821428571428571 0.05611264402767441 F11, GP1BB, KLKB1, SERPINE1, COL3A1, TFPI, F8, SERPIND1, LMAN1, ANXA5, TFPI2 751 102 13528 1.9426124644265161 1.0 0.9664138915121426 64.30957680018507 BIOCARTA h_intrinsicPathway:Intrinsic Prothrombin Activation Pathway 4 0.35714285714285715 0.07657971776806408 F11, KLKB1, F8, CYP4V2 87 17 1437 3.8864097363083165 0.9999997333830465 0.7799158452064453 62.849735345543245 GOTERM_BP_FAT GO:0050878~regulation of body fluid levels 12 1.0714285714285714 0.15931195932461856 F11, GP1BB, KLKB1, HPS4, SERPINE1, COL3A1, TFPI, F8, SERPIND1, LMAN1, ANXA5, TFPI2 751 141 13528 1.533048134402357 1.0 0.9827834950163519 95.47713499231479 GOTERM_BP_FAT GO:0050819~negative regulation of coagulation 4 0.35714285714285715 0.17240077394888698 F11, KLKB1, SERPINE1, ANXA5 751 26 13528 2.771279319881184 1.0 0.985225647256458 96.58153483081125 GOTERM_BP_FAT GO:0042060~wound healing 15 1.3392857142857142 0.17473293030531972 F11, COL3A1, F8, MSTN, LMAN1, ANXA5, MIA3, GP1BB, KLKB1, SERPINE1, SERPINB2, TFPI, SERPIND1, LOX, TFPI2 751 191 13528 1.4146582915623844 1.0 0.9846504762038794 96.74938157306094 GOTERM_BP_FAT GO:0050818~regulation of coagulation 5 0.4464285714285714 0.19065231224939572 F11, KLKB1, PSEN2, SERPINE1, ANXA5 751 41 13528 2.1967458023448407 1.0 0.9841331399108887 97.70362705688565 GOTERM_BP_FAT GO:0030195~negative regulation of blood coagulation 3 0.26785714285714285 0.36716575204022195 F11, KLKB1, SERPINE1 751 23 13528 2.349562901638395 1.0 0.988861079767052 99.97150149109886 KEGG_PATHWAY hsa04610:Complement and coagulation cascades 6 0.5357142857142857 0.3853726442492836 F11, KLKB1, SERPINE1, TFPI, F8, SERPIND1 301 69 5085 1.4690163224035822 1.0 0.9096619253750085 99.72494700634765 GOTERM_BP_FAT GO:0009611~response to wounding 30 2.6785714285714284 0.5577009480867984 ACHE, COL3A1, TLR3, TAC1, TLR5, LMAN1, TMED7, MIA3, GP1BB, AOAH, BCL2, KLKB1, RAC1, SERPINE1, SCN9A, TICAM2, LOX, LBP, TFPI2, EPO, F11, F8, MSTN, ANXA5, CDO1, NLRP3, AOX1, SERPINB2, TFPI, JAK2, SERPIND1 751 530 13528 1.0196216365600583 1.0 0.9954394897751295 99.99995222144165 GOTERM_BP_FAT GO:0030193~regulation of blood coagulation 3 0.26785714285714285 0.6009253636524992 F11, KLKB1, SERPINE1 751 36 13528 1.501109631602308 1.0 0.9964851617831675 99.99999237179881 SP_PIR_KEYWORDS plasma 5 0.4464285714285714 0.7377258162928657 F11, KLKB1, F8, SERPIND1, HGFAC 1027 93 19235 1.0069520788181467 1.0 0.9789853347298164 99.99999968168706 GOTERM_MF_FAT GO:0017171~serine hydrolase activity 8 0.7142857142857143 0.8810339922908966 F11, ACHE, SEC11C, KLKB1, SERPINE1, SERPINB2, RELN, HGFAC 725 180 12983 0.7958927203065134 1.0 0.9999627415700235 99.99999999999955 GOTERM_MF_FAT GO:0008236~serine-type peptidase activity 7 0.625 0.9367586127621829 F11, SEC11C, KLKB1, SERPINE1, SERPINB2, RELN, HGFAC 725 178 12983 0.7042309182487408 1.0 0.9999943786657383 100.0 GOTERM_MF_FAT GO:0004252~serine-type endopeptidase activity 5 0.4464285714285714 0.9753007503032762 F11, KLKB1, SERPINE1, SERPINB2, HGFAC 725 154 12983 0.5814151365875504 1.0 0.9999997687508754 100.0 Annotation Cluster 52 Enrichment Score: 0.7676742439453432 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:SAM 9 0.8035714285714285 0.06775994967172519 EPHA4, PPP1R9A, L3MBTL4, ZAK, SAMD9, SAMHD1, SAMD9L, EPHB4, SHANK3 1024 81 19113 2.0738932291666665 1.0 0.9999991228867381 71.13192787501939 INTERPRO IPR001660:Sterile alpha motif SAM 9 0.8035714285714285 0.14085001886711335 EPHA4, PPP1R9A, L3MBTL4, ZAK, SAMD9, SAMHD1, SAMD9L, EPHB4, SHANK3 920 93 16659 1.752349228611501 1.0 0.9971561981762492 91.64050076501545 SMART SM00454:SAM 9 0.8035714285714285 0.15316298983198362 EPHA4, PPP1R9A, L3MBTL4, ZAK, SAMD9, SAMHD1, SAMD9L, EPHB4, SHANK3 513 93 9079 1.7126957177890965 1.0 0.9769079325596888 88.78978339758426 INTERPRO IPR013761:Sterile alpha motif-type 7 0.625 0.25075759930161423 EPHA4, PPP1R9A, L3MBTL4, ZAK, SAMD9, EPHB4, SHANK3 920 77 16659 1.6461462450592885 1.0 0.9989840005385812 99.10799948875166 INTERPRO IPR011510:Sterile alpha motif homology 2 4 0.35714285714285715 0.3958137320787338 EPHA4, PPP1R9A, ZAK, SAMHD1 920 41 16659 1.7665959703075294 1.0 0.9996546328381818 99.9735363896882 Annotation Cluster 53 Enrichment Score: 0.7524208305214474 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043030~regulation of macrophage activation 3 0.26785714285714285 0.12120616114417043 BPI, LBP, HSPD1 751 11 13528 4.912722430698462 1.0 0.9707918536778892 90.02552137246539 GOTERM_MF_FAT GO:0001530~lipopolysaccharide binding 3 0.26785714285714285 0.1416628292578552 BPI, LBP, HSPD1 725 12 12983 4.4768965517241375 1.0 0.9747499885061646 90.64832706821572 GOTERM_BP_FAT GO:0032675~regulation of interleukin-6 production 4 0.35714285714285715 0.3220749149897021 BPI, TLR3, LBP, HSPD1 751 36 13528 2.0014795088030772 1.0 0.9877246963956805 99.902698545993 Annotation Cluster 54 Enrichment Score: 0.7403768054503963 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002757~immune response-activating signal transduction 7 0.625 0.06657965112130493 MAPK1, SLA2, PSEN2, TLR3, SH2B2, MALT1, HSPD1 751 52 13528 2.424869404896036 1.0 0.9624111797553132 70.74839942877699 GOTERM_BP_FAT GO:0002764~immune response-regulating signal transduction 7 0.625 0.08853648114201976 MAPK1, SLA2, PSEN2, TLR3, SH2B2, MALT1, HSPD1 751 56 13528 2.2516644474034617 1.0 0.9670896665835401 80.87020800529275 GOTERM_BP_FAT GO:0048584~positive regulation of response to stimulus 19 1.6964285714285714 0.10596093420554722 BRCC3, TAOK2, FAM175A, SLA2, TLR3, TAC1, MALT1, IL21, SRC, MAPK1, GHRH, PSEN2, MAPK8IP2, TGM2, SH2B2, JAK2, HSPD1, LBP, CD226 751 236 13528 1.4502245593446028 1.0 0.9702657288634913 86.44332663446339 GOTERM_BP_FAT GO:0050851~antigen receptor-mediated signaling pathway 5 0.4464285714285714 0.10768277343791284 MAPK1, SLA2, PSEN2, SH2B2, MALT1 751 33 13528 2.7292902392769234 1.0 0.9673033957101151 86.90165742929717 GOTERM_BP_FAT GO:0031349~positive regulation of defense response 8 0.7142857142857143 0.10907558785531317 TGM2, TLR3, TAC1, JAK2, LBP, HSPD1, IL21, CD226 751 73 13528 1.9740619812852271 1.0 0.967616226613153 87.26166362465403 GOTERM_BP_FAT GO:0002429~immune response-activating cell surface receptor signaling pathway 5 0.4464285714285714 0.16825245860016524 MAPK1, SLA2, PSEN2, SH2B2, MALT1 751 39 13528 2.30939943323432 1.0 0.9840269833257305 96.26257993026721 GOTERM_BP_FAT GO:0002768~immune response-regulating cell surface receptor signaling pathway 5 0.4464285714285714 0.20218827037598214 MAPK1, SLA2, PSEN2, SH2B2, MALT1 751 42 13528 2.14444233086044 1.0 0.9835021512991359 98.22250190063903 GOTERM_BP_FAT GO:0050852~T cell receptor signaling pathway 3 0.26785714285714285 0.36716575204022195 MAPK1, PSEN2, MALT1 751 23 13528 2.349562901638395 1.0 0.988861079767052 99.97150149109886 GOTERM_BP_FAT GO:0050778~positive regulation of immune response 10 0.8928571428571428 0.4129851967535603 MAPK1, SLA2, PSEN2, TLR3, SH2B2, MALT1, LBP, HSPD1, IL21, CD226 751 145 13528 1.2422976261536343 1.0 0.9914480147542912 99.99254450076718 GOTERM_BP_FAT GO:0002253~activation of immune response 7 0.625 0.42220158299995353 MAPK1, SLA2, PSEN2, TLR3, SH2B2, MALT1, HSPD1 751 94 13528 1.3414171176020624 1.0 0.9918493073829787 99.9943783855851 GOTERM_BP_FAT GO:0002684~positive regulation of immune system process 15 1.3392857142857142 0.4490946807435034 SLA2, TAC1, TLR3, MALT1, ITPKB, IL21, PDCD1LG2, MAPK1, MIA3, PSEN2, SH2B2, HSPD1, LBP, CD226, IL2 751 238 13528 1.1352929986908211 1.0 0.992667745172272 99.99759804878055 Annotation Cluster 55 Enrichment Score: 0.7369275812402577 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF005524:melanocortin receptor 3 0.26785714285714285 0.025426438086664265 MC2R, MC4R, MC5R 395 5 7396 11.234430379746835 0.9999408535714671 0.7511201196204613 29.97218706925171 INTERPRO IPR001671:Melanocortin/ACTH receptor 3 0.26785714285714285 0.02718968103952446 MC2R, MC4R, MC5R 920 5 16659 10.864565217391304 0.9999999999999998 0.9510128557465979 36.27817237430829 GOTERM_MF_FAT GO:0004977~melanocortin receptor activity 3 0.26785714285714285 0.04009518587638619 MC2R, MC4R, MC5R 725 6 12983 8.953793103448275 0.9999999999999996 0.9206739295277402 46.99460675112015 GOTERM_BP_FAT GO:0007187~G-protein signaling, coupled to cyclic nucleotide second messenger 9 0.8035714285714285 0.306068404259753 CALCR, GNAL, CHRM5, GALR1, GHRH, MC2R, MC4R, MC5R, CALCRL 751 115 13528 1.4097377409830372 1.0 0.9863552889712822 99.85245084767318 GOTERM_MF_FAT GO:0042562~hormone binding 4 0.35714285714285715 0.5197307996690993 CALCR, MC2R, MC4R, MC5R 725 49 12983 1.4618437719915551 1.0 0.9982682999756888 99.99885413901144 GOTERM_MF_FAT GO:0001653~peptide receptor activity 7 0.625 0.6166180935741554 QRFPR, GALR1, MC2R, MC4R, MC5R, NPSR1, NPY6R 725 114 12983 1.099588626739262 1.0 0.9992739869638941 99.99996522908936 GOTERM_MF_FAT GO:0008528~peptide receptor activity, G-protein coupled 7 0.625 0.6166180935741554 QRFPR, GALR1, MC2R, MC4R, MC5R, NPSR1, NPY6R 725 114 12983 1.099588626739262 1.0 0.9992739869638941 99.99996522908936 UP_SEQ_FEATURE lipid moiety-binding region:S-palmitoyl cysteine 9 0.8035714285714285 0.7588710733332098 STK16, GNAL, GALR1, CDC42SE2, MC2R, MC4R, MC5R, RFTN2, SLC4A3 1024 181 19113 0.9280958649861879 1.0 0.9999999994759492 99.99999999884845 Annotation Cluster 56 Enrichment Score: 0.7299357839586333 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE region of interest:N-terminal arm 3 0.26785714285714285 0.0502225909653637 CRYBB1, CRYBA2, CRYBA4 1024 7 19113 7.999302455357142 1.0 0.9999996241796358 59.84474922773539 PIR_SUPERFAMILY PIRSF002281:beta/gamma crystallins 3 0.26785714285714285 0.11331272678059284 CRYBB1, CRYBA2, CRYBA4 395 11 7396 5.106559263521288 1.0 0.9893897905992712 81.05481201102343 UP_SEQ_FEATURE domain:Beta/gamma crystallin 'Greek key' 4 3 0.26785714285714285 0.1704851640160386 CRYBB1, CRYBA2, CRYBA4 1024 14 19113 3.999651227678571 1.0 0.999992345055512 96.34748367818815 UP_SEQ_FEATURE domain:Beta/gamma crystallin 'Greek key' 2 3 0.26785714285714285 0.1901068575534391 CRYBB1, CRYBA2, CRYBA4 1024 15 19113 3.7330078125 1.0 0.9999928216140932 97.60944363856603 UP_SEQ_FEATURE domain:Beta/gamma crystallin 'Greek key' 3 3 0.26785714285714285 0.1901068575534391 CRYBB1, CRYBA2, CRYBA4 1024 15 19113 3.7330078125 1.0 0.9999928216140932 97.60944363856603 UP_SEQ_FEATURE domain:Beta/gamma crystallin 'Greek key' 1 3 0.26785714285714285 0.1901068575534391 CRYBB1, CRYBA2, CRYBA4 1024 15 19113 3.7330078125 1.0 0.9999928216140932 97.60944363856603 INTERPRO IPR001064:Beta and gamma crystallin 3 0.26785714285714285 0.19916557223801218 CRYBB1, CRYBA2, CRYBA4 920 15 16659 3.6215217391304346 1.0 0.9970688892748505 97.35060555376069 SMART SM00247:XTALbg 3 0.26785714285714285 0.20596239176724973 CRYBB1, CRYBA2, CRYBA4 513 15 9079 3.5395711500974656 1.0 0.9801711177868314 95.19617689663824 SP_PIR_KEYWORDS eye lens protein 3 0.26785714285714285 0.2289266149381103 CRYBB1, CRYBA2, CRYBA4 1027 17 19235 3.3051721175325044 1.0 0.8216237420007 97.76403375711013 GOTERM_MF_FAT GO:0005212~structural constituent of eye lens 3 0.26785714285714285 0.24443432549795174 CRYBB1, CRYBA2, CRYBA4 725 17 12983 3.160162271805274 1.0 0.9906583551143602 98.70659060876002 UP_SEQ_FEATURE region of interest:Connecting peptide 3 0.26785714285714285 0.6109250827066781 CRYBB1, CRYBA2, CRYBA4 1024 38 19113 1.473555715460526 1.0 0.9999999505564676 99.99999449723313 Annotation Cluster 57 Enrichment Score: 0.7239209538717034 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001508~regulation of action potential 9 0.8035714285714285 0.03373887529311394 SRI, GJD2, SCN1A, NAB1, TAC1, CHRNA1, AFG3L2, GJC3, MBP 751 68 13528 2.3841152972507245 1.0 0.9575672724140195 45.79096476457259 GOTERM_BP_FAT GO:0042391~regulation of membrane potential 12 1.0714285714285714 0.12446423624884823 SRI, GJD2, SCN1A, AIFM3, HTT, BCL2, NAB1, TAC1, CHRNA1, AFG3L2, GJC3, MBP 751 134 13528 1.6131327384383014 1.0 0.9726556557468273 90.66507735958649 GOTERM_BP_FAT GO:0019228~regulation of action potential in neuron 6 0.5357142857142857 0.17840917535562695 SCN1A, NAB1, CHRNA1, AFG3L2, GJC3, MBP 751 54 13528 2.0014795088030777 1.0 0.9846269749974524 96.9982569041437 GOTERM_BP_FAT GO:0042552~myelination 4 0.35714285714285715 0.35297248777143886 NAB1, AFG3L2, GJC3, MBP 751 38 13528 1.8961384820239682 1.0 0.9889317932629438 99.95766690010403 GOTERM_BP_FAT GO:0008366~axon ensheathment 4 0.35714285714285715 0.4140669122585251 NAB1, AFG3L2, GJC3, MBP 751 42 13528 1.7155538646883521 1.0 0.991325357664011 99.99278584307227 GOTERM_BP_FAT GO:0007272~ensheathment of neurons 4 0.35714285714285715 0.4140669122585251 NAB1, AFG3L2, GJC3, MBP 751 42 13528 1.7155538646883521 1.0 0.991325357664011 99.99278584307227 Annotation Cluster 58 Enrichment Score: 0.7209176888565736 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032720~negative regulation of tumor necrosis factor production 4 0.35714285714285715 0.011083720796189078 BPI, CIDEA, CHRNA7, LBP 751 9 13528 8.005918035212309 0.9999999999999573 0.8715578943564216 18.032574646496947 GOTERM_BP_FAT GO:0032680~regulation of tumor necrosis factor production 5 0.4464285714285714 0.09013539824861948 BPI, CIDEA, TLR3, CHRNA7, LBP 751 31 13528 2.905373480520596 1.0 0.9647339453027349 81.460153728269 GOTERM_BP_FAT GO:0032675~regulation of interleukin-6 production 4 0.35714285714285715 0.3220749149897021 BPI, TLR3, LBP, HSPD1 751 36 13528 2.0014795088030772 1.0 0.9877246963956805 99.902698545993 GOTERM_BP_FAT GO:0001818~negative regulation of cytokine production 4 0.35714285714285715 0.35297248777143886 BPI, CIDEA, CHRNA7, LBP 751 38 13528 1.8961384820239682 1.0 0.9889317932629438 99.95766690010403 GOTERM_BP_FAT GO:0001817~regulation of cytokine production 12 1.0714285714285714 0.42137903821493844 TLR3, CIDEA, MALT1, INHA, NLRP3, IL21, TMED7, BPI, TICAM2, JAK2, CHRNA7, HSPD1, LBP 751 181 13528 1.194252966578632 1.0 0.9918721312709224 99.9942338827295 GOTERM_BP_FAT GO:0042742~defense response to bacterium 3 0.26785714285714285 0.9875116401091653 BPI, TLR3, LBP 751 112 13528 0.48249952444359895 1.0 0.9999999512665181 100.0 Annotation Cluster 59 Enrichment Score: 0.7205957508282947 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006826~iron ion transport 6 0.5357142857142857 0.02025897602962927 FTMT, STEAP4, TFR2, STEAP2, STEAP1, SLC40A1 751 29 13528 3.7268928784609026 1.0 0.9051454853166 30.59081759405239 GOTERM_BP_FAT GO:0000041~transition metal ion transport 9 0.8035714285714285 0.042096432768886693 FTMT, STEAP4, SLC39A10, TFR2, TRPC7, STEAP2, STEAP1, SLC40A1, SCO2 751 71 13528 2.283378031169708 1.0 0.9561076237032479 53.57383722596458 GOTERM_MF_FAT GO:0009055~electron carrier activity 18 1.607142857142857 0.11157276976244157 CYP3A4, STEAP4, CYP3A5, CYP3A7, AIFM3, CYP51A1, CYP20A1, CYP4V2, GLDC, CYP3A43, FMO5, P4HA2, NDUFV2, AOX1, TXNRD2, STEAP2, STEAP1, DEGS1 725 221 12983 1.4585364331408956 1.0 0.9510381904739498 84.04074014603633 UP_SEQ_FEATURE domain:Ferric oxidoreductase 3 0.26785714285714285 0.1142847264848825 STEAP4, STEAP2, STEAP1 1024 11 19113 5.090465198863637 1.0 0.9999711418782754 88.33943567872686 SP_PIR_KEYWORDS iron transport 4 0.35714285714285715 0.12146009536904318 STEAP4, STEAP2, STEAP1, SLC40A1 1027 23 19235 3.2572710723508744 1.0 0.7435721917505029 84.9389329081347 INTERPRO IPR013130:Ferric reductase-like transmembrane component, N-terminal 3 0.26785714285714285 0.13919377835588823 STEAP4, STEAP2, STEAP1 920 12 16659 4.526902173913043 1.0 0.9974294631310744 91.37312168827751 GOTERM_MF_FAT GO:0048037~cofactor binding 19 1.6964285714285714 0.16036133019724175 AADAT, STEAP4, CTBP1, AIFM3, NFS1, ASNS, AGXT, GLDC, TYMS, FMO5, MIOX, AOX1, NDUFV2, TXNRD2, PARP1, STEAP2, GAD1, HPGD, STEAP1 725 249 12983 1.3664423210081706 1.0 0.9814600351066969 93.35480586280778 GOTERM_MF_FAT GO:0050660~FAD binding 7 0.625 0.21223189019040983 FMO5, STEAP4, AIFM3, AOX1, TXNRD2, STEAP2, STEAP1 725 72 12983 1.7410153256704983 1.0 0.9899088089903751 97.52877305808077 GOTERM_MF_FAT GO:0005507~copper ion binding 6 0.5357142857142857 0.34042756695084 STEAP4, F8, LOX, STEAP2, STEAP1, SCO2 725 69 12983 1.5571814092953522 1.0 0.992864364504377 99.84283125291654 SP_PIR_KEYWORDS copper 5 0.4464285714285714 0.36200898625156286 STEAP4, LOX, STEAP2, STEAP1, SCO2 1027 57 19235 1.6429218128085552 1.0 0.8887421157887481 99.85984565175659 GOTERM_MF_FAT GO:0050662~coenzyme binding 12 1.0714285714285714 0.4289959086811715 FMO5, STEAP4, CTBP1, AIFM3, NDUFV2, AOX1, MIOX, TXNRD2, STEAP2, PARP1, STEAP1, HPGD 725 181 12983 1.1872432844351306 1.0 0.9962434951718091 99.98321419098751 SP_PIR_KEYWORDS Flavoprotein 7 0.625 0.5098243359617166 FMO5, STEAP4, AIFM3, AOX1, TXNRD2, STEAP2, STEAP1 1027 107 19235 1.225281875346941 1.0 0.932902404775172 99.99702636358253 SP_PIR_KEYWORDS FAD 7 0.625 0.5724134857820921 FMO5, STEAP4, AIFM3, AOX1, TXNRD2, STEAP2, STEAP1 1027 114 19235 1.1500452689659886 1.0 0.9527864247996456 99.99959637098272 UP_SEQ_FEATURE nucleotide phosphate-binding region:FAD 3 0.26785714285714285 0.8451988924403908 FMO5, AIFM3, TXNRD2 1024 61 19113 0.9179527407786886 1.0 0.9999999999791913 99.99999999999955 Annotation Cluster 60 Enrichment Score: 0.7194631294440866 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:MORN 3 3 0.26785714285714285 0.1704851640160386 ALS2, RSPH10B2, ANKMY1, RSPH10B 1024 14 19113 3.999651227678571 1.0 0.999992345055512 96.34748367818815 UP_SEQ_FEATURE repeat:MORN 1 3 0.26785714285714285 0.1901068575534391 ALS2, RSPH10B2, ANKMY1, RSPH10B 1024 15 19113 3.7330078125 1.0 0.9999928216140932 97.60944363856603 UP_SEQ_FEATURE repeat:MORN 2 3 0.26785714285714285 0.1901068575534391 ALS2, RSPH10B2, ANKMY1, RSPH10B 1024 15 19113 3.7330078125 1.0 0.9999928216140932 97.60944363856603 INTERPRO IPR003409:MORN motif 3 0.26785714285714285 0.19916557223801218 ALS2, RSPH10B2, ANKMY1, RSPH10B 920 15 16659 3.6215217391304346 1.0 0.9970688892748505 97.35060555376069 SMART SM00698:MORN 3 0.26785714285714285 0.20596239176724973 ALS2, RSPH10B2, ANKMY1, RSPH10B 513 15 9079 3.5395711500974656 1.0 0.9801711177868314 95.19617689663824 Annotation Cluster 61 Enrichment Score: 0.7143117513229139 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF002448:voltage-gated sodium channel 5 0.4464285714285714 0.0012884437109565241 SCN1A, SCN3A, SCN2A, SCN9A, SCN7A 395 10 7396 9.362025316455696 0.38574538168661054 0.14994020337010316 1.76766836421689 INTERPRO IPR001696:Na+ channel 5 0.4464285714285714 0.0014779199974623027 SCN1A, SCN3A, SCN2A, SCN9A, SCN7A 920 10 16659 9.053804347826086 0.8565751866084907 0.32185141688655605 2.388849088946965 INTERPRO IPR010526:Sodium ion transport-associated 5 0.4464285714285714 0.0014779199974623027 SCN1A, SCN3A, SCN2A, SCN9A, SCN7A 920 10 16659 9.053804347826086 0.8565751866084907 0.32185141688655605 2.388849088946965 GOTERM_CC_FAT GO:0001518~voltage-gated sodium channel complex 5 0.4464285714285714 0.0032977754960487023 SCN1A, SCN3A, SCN2A, SCN9A, SCN7A 713 12 12782 7.469611968209444 0.7971843303301105 0.5496493925063611 4.623352065254527 GOTERM_CC_FAT GO:0034706~sodium channel complex 5 0.4464285714285714 0.007956766597296251 SCN1A, SCN3A, SCN2A, SCN9A, SCN7A 713 15 12782 5.9756895745675545 0.9789001480241409 0.4743299488845051 10.81696985459123 GOTERM_MF_FAT GO:0005248~voltage-gated sodium channel activity 5 0.4464285714285714 0.007988482949624062 SCN1A, SCN3A, SCN2A, SCN9A, SCN7A 725 15 12983 5.96919540229885 0.9990450266377554 0.8242085232755652 11.69879645407066 SP_PIR_KEYWORDS sodium channel 5 0.4464285714285714 0.06622964715601329 SCN1A, SCN3A, SCN2A, SCN9A, SCN7A 1027 29 19235 3.2291911493133667 1.0 0.653623898613309 63.276575360812046 GOTERM_MF_FAT GO:0005272~sodium channel activity 5 0.4464285714285714 0.10033464686971036 SCN1A, SCN3A, SCN2A, SCN9A, SCN7A 725 32 12983 2.7980603448275865 1.0 0.9576181300525566 80.60472874157587 INTERPRO IPR005821:Ion transport 10 0.8928571428571428 0.1533232776692135 SCN1A, TRPC3, SCN3A, RYR3, SCN2A, TRPC7, SCN9A, SCN7A, KCNV2, KCNG2 920 110 16659 1.6461462450592885 1.0 0.9976895266173255 93.41811754862077 INTERPRO IPR000048:IQ calmodulin-binding region 8 0.7142857142857143 0.20378253876885688 SCN1A, SCN3A, MYO1B, SCN2A, MYO3B, MYH11, SCN9A, SCN7A 920 87 16659 1.6650674662668665 1.0 0.9971682732061418 97.58955648167317 SMART SM00015:IQ 8 0.7142857142857143 0.21877978937046133 SCN1A, SCN3A, MYO1B, SCN2A, MYO3B, MYH11, SCN9A, SCN7A 513 87 9079 1.6273890345275706 1.0 0.9708279080604449 96.1224744049161 GOTERM_BP_FAT GO:0030001~metal ion transport 31 2.767857142857143 0.2209359426554794 SRI, STEAP4, FTMT, SCN1A, SCN3A, SLC39A10, TFR2, SLC38A11, SLC23A1, BHLHA15, SCN9A, VPS4B, CHRNA7, SCN7A, NEDD4L, SCO2, NFATC1, KCNG2, SLC12A6, TRPC3, SLC12A2, TRPC7, SCN2A, KCNV2, RYR3, PSEN2, KCTD18, KCTD13, STEAP2, SLC40A1, STEAP1 751 465 13528 1.2008877052818465 1.0 0.9835027614009837 98.83704984808377 GOTERM_BP_FAT GO:0006814~sodium ion transport 10 0.8928571428571428 0.2946346601545055 SLC12A6, SCN1A, SLC23A1, SLC12A2, SCN3A, SCN2A, SCN9A, SLC38A11, NEDD4L, SCN7A 751 130 13528 1.385639659940592 1.0 0.9854224923857187 99.80250226826207 GOTERM_BP_FAT GO:0006811~ion transport 47 4.196428571428571 0.3152265182524284 SRI, STEAP4, FTMT, CLCN3, SCN1A, SCN3A, SLC39A10, CHKB, GLRA3, TFR2, SLC38A11, ATP5G3, SLC23A1, BHLHA15, VPS4B, SCN9A, CHRNA7, SLC25A1, SCN7A, NEDD4L, CHRNA1, SLC4A3, SLC1A1, SCO2, NFATC1, KCNG2, SLC12A6, CPT1B, ATP5J2, TRPC3, MLC1, SLC12A2, HTT, SCN2A, TRPC7, CLIC2, KCNV2, PKD2L2, SLC25A12, P2RX6, SLC26A5, RYR3, PSEN2, KCTD18, KCTD13, STEAP2, SLC40A1, STEAP1 751 768 13528 1.102377385707945 1.0 0.987425215604611 99.88358760630162 GOTERM_BP_FAT GO:0006812~cation transport 34 3.0357142857142856 0.359656314515535 SRI, STEAP4, FTMT, SCN1A, SCN3A, SLC39A10, CHKB, TFR2, SLC38A11, ATP5G3, SLC23A1, BHLHA15, SCN9A, VPS4B, CHRNA7, SCN7A, NEDD4L, SCO2, NFATC1, KCNG2, SLC12A6, CPT1B, ATP5J2, TRPC3, SLC12A2, TRPC7, SCN2A, KCNV2, RYR3, PSEN2, KCTD18, KCTD13, STEAP2, SLC40A1, STEAP1 751 553 13528 1.1075094569507082 1.0 0.988632004697962 99.96482580398515 UP_SEQ_FEATURE domain:IQ 5 0.4464285714285714 0.3890630787421081 SCN3A, SCN2A, MYH11, SCN9A, EWSR1 1024 59 19113 1.5817829713983051 1.0 0.9999982632565095 99.98376074662413 UP_SEQ_FEATURE repeat:I 3 0.26785714285714285 0.40905874301878076 SCN1A, SCN2A, SCN9A 1024 26 19113 2.1536583533653846 1.0 0.9999978925619387 99.99099137347375 UP_SEQ_FEATURE repeat:II 3 0.26785714285714285 0.40905874301878076 SCN1A, SCN2A, SCN9A 1024 26 19113 2.1536583533653846 1.0 0.9999978925619387 99.99099137347375 UP_SEQ_FEATURE repeat:III 3 0.26785714285714285 0.40905874301878076 SCN1A, SCN2A, SCN9A 1024 26 19113 2.1536583533653846 1.0 0.9999978925619387 99.99099137347375 UP_SEQ_FEATURE repeat:IV 3 0.26785714285714285 0.40905874301878076 SCN1A, SCN2A, SCN9A 1024 26 19113 2.1536583533653846 1.0 0.9999978925619387 99.99099137347375 SP_PIR_KEYWORDS Sodium transport 8 0.7142857142857143 0.42464220940511305 SCN1A, SLC23A1, SLC12A2, SCN3A, SCN2A, SCN9A, SLC38A11, SCN7A 1027 116 19235 1.2916764597253467 1.0 0.9097691196903885 99.96905708205301 SP_PIR_KEYWORDS Sodium 8 0.7142857142857143 0.42464220940511305 SCN1A, SLC23A1, SLC12A2, SCN3A, SCN2A, SCN9A, SLC38A11, SCN7A 1027 116 19235 1.2916764597253467 1.0 0.9097691196903885 99.96905708205301 GOTERM_MF_FAT GO:0015267~channel activity 25 2.232142857142857 0.45476686153778206 GJA8, SCN1A, CLCN3, SCN3A, GLRA3, GJA5, GPM6A, SCN9A, CHRNA7, SCN7A, CHRNA1, KCNG2, GJD2, MLC1, TRPC3, TRPC7, SCN2A, CLIC2, KCNV2, PKD2L2, P2RX6, RYR3, KCTD18, KCTD13, STEAP1 725 412 12983 1.0866253766320724 1.0 0.9972842068472116 99.99179998347881 GOTERM_CC_FAT GO:0034703~cation channel complex 9 0.8035714285714285 0.4554189259789585 SCN1A, SCN3A, SCN2A, SCN9A, KCTD18, SCN7A, KCTD13, KCNV2, KCNG2 713 132 12782 1.2223001402524543 1.0 0.9559637091013419 99.98349254081535 GOTERM_MF_FAT GO:0022803~passive transmembrane transporter activity 25 2.232142857142857 0.46176111475991716 GJA8, SCN1A, CLCN3, SCN3A, GLRA3, GJA5, GPM6A, SCN9A, CHRNA7, SCN7A, CHRNA1, KCNG2, GJD2, MLC1, TRPC3, TRPC7, SCN2A, CLIC2, KCNV2, PKD2L2, P2RX6, RYR3, KCTD18, KCTD13, STEAP1 725 413 12983 1.0839943224513653 1.0 0.997439096714747 99.99328825868898 GOTERM_CC_FAT GO:0034702~ion channel complex 13 1.1607142857142858 0.472413340580223 SCN1A, SCN3A, GLRA3, SCN2A, CLIC2, KCNV2, SCN9A, KCTD18, CHRNA7, SCN7A, KCTD13, CHRNA1, KCNG2 713 205 12782 1.136838504429925 1.0 0.9585814464526174 99.98951980900473 GOTERM_MF_FAT GO:0046873~metal ion transmembrane transporter activity 20 1.7857142857142856 0.47994695305752566 SCN1A, TRPC3, SCN3A, SLC39A10, ABCB11, SCN2A, TRPC7, KCNV2, SLC23A1, P2RX6, GPM6A, RYR3, SCN9A, KCTD18, CHRNA7, SCN7A, CHRNA1, KCTD13, SLC40A1, KCNG2 725 328 12983 1.0919259882253995 1.0 0.9977466364078549 99.99606197732639 GOTERM_MF_FAT GO:0031402~sodium ion binding 8 0.7142857142857143 0.4800371415907617 SCN1A, SLC23A1, SLC12A2, SCN3A, SCN2A, SCN9A, SLC38A11, SCN7A 725 117 12983 1.2244503389330974 1.0 0.9975995209990194 99.99607255788217 GOTERM_MF_FAT GO:0005261~cation channel activity 16 1.4285714285714286 0.5735431795284411 SCN1A, TRPC3, SCN3A, SCN2A, TRPC7, KCNV2, P2RX6, GPM6A, RYR3, SCN9A, KCTD18, CHRNA7, SCN7A, KCTD13, CHRNA1, KCNG2 725 275 12983 1.0418959247648902 1.0 0.998931635942582 99.99981863515859 GOTERM_MF_FAT GO:0022843~voltage-gated cation channel activity 9 0.8035714285714285 0.5798481384298549 SCN1A, SCN3A, SCN2A, SCN9A, KCTD18, SCN7A, KCTD13, KCNV2, KCNG2 725 147 12983 1.0963828289936663 1.0 0.9989895256875913 99.9998560511177 SP_PIR_KEYWORDS ionic channel 17 1.5178571428571428 0.6315246889275653 SCN1A, MLC1, TRPC3, SCN3A, GLRA3, SCN2A, TRPC7, CLIC2, KCNV2, PKD2L2, P2RX6, RYR3, SCN9A, CHRNA7, SCN7A, CHRNA1, KCNG2 1027 318 19235 1.0012523500701194 1.0 0.9620379325772448 99.99995414630942 GOTERM_MF_FAT GO:0022832~voltage-gated channel activity 11 0.9821428571428571 0.6532458489860529 CLCN3, SCN1A, SCN3A, SCN2A, SCN9A, KCTD18, CLIC2, SCN7A, KCTD13, KCNV2, KCNG2 725 195 12983 1.0101715296198055 1.0 0.9993549545823529 99.99999267630083 GOTERM_MF_FAT GO:0005244~voltage-gated ion channel activity 11 0.9821428571428571 0.6532458489860529 CLCN3, SCN1A, SCN3A, SCN2A, SCN9A, KCTD18, CLIC2, SCN7A, KCTD13, KCNV2, KCNG2 725 195 12983 1.0101715296198055 1.0 0.9993549545823529 99.99999267630083 SP_PIR_KEYWORDS ion transport 30 2.6785714285714284 0.6614540551408373 STEAP4, CLCN3, SCN1A, SCN3A, SLC39A10, GLRA3, SLC38A11, ATP5G3, SLC23A1, SCN9A, CHRNA7, SCN7A, CHRNA1, SLC4A3, KCNG2, SLC12A6, ATP5J2, TRPC3, MLC1, SLC12A2, TRPC7, SCN2A, CLIC2, KCNV2, PKD2L2, P2RX6, RYR3, STEAP2, STEAP1, SLC40A1 1027 578 19235 0.9721094463330896 1.0 0.9669054004053975 99.99998670971932 GOTERM_MF_FAT GO:0022836~gated channel activity 17 1.5178571428571428 0.6623115163476393 CLCN3, SCN1A, TRPC3, SCN3A, GLRA3, SCN2A, CLIC2, KCNV2, P2RX6, RYR3, SCN9A, KCTD18, CHRNA7, SCN7A, KCTD13, CHRNA1, KCNG2 725 310 12983 0.9820289210233593 1.0 0.9993596251211684 99.99999514425024 GOTERM_MF_FAT GO:0005216~ion channel activity 21 1.875 0.6666578270776883 CLCN3, SCN1A, MLC1, TRPC3, SCN3A, GLRA3, SCN2A, TRPC7, CLIC2, KCNV2, PKD2L2, P2RX6, GPM6A, RYR3, SCN9A, KCTD18, CHRNA7, SCN7A, KCTD13, CHRNA1, KCNG2 725 386 12983 0.9742469179917814 1.0 0.9993785892840789 99.99999602822236 GOTERM_BP_FAT GO:0015672~monovalent inorganic cation transport 17 1.5178571428571428 0.6922900873012247 SLC12A6, SCN1A, ATP5J2, SCN3A, SLC12A2, SCN2A, SLC38A11, KCNV2, ATP5G3, SLC23A1, SCN9A, VPS4B, KCTD18, NEDD4L, SCN7A, KCTD13, KCNG2 751 318 13528 0.9629759900844995 1.0 0.9983098125339809 99.99999992621771 SP_PIR_KEYWORDS voltage-gated channel 8 0.7142857142857143 0.6944148827414733 SCN1A, SCN3A, SCN2A, SCN9A, CLIC2, SCN7A, KCNV2, KCNG2 1027 150 19235 0.9988964621876015 1.0 0.9723684259930374 99.99999702691743 GOTERM_MF_FAT GO:0022838~substrate specific channel activity 21 1.875 0.7182476704812752 CLCN3, SCN1A, MLC1, TRPC3, SCN3A, GLRA3, SCN2A, TRPC7, CLIC2, KCNV2, PKD2L2, P2RX6, GPM6A, RYR3, SCN9A, KCTD18, CHRNA7, SCN7A, KCTD13, CHRNA1, KCNG2 725 398 12983 0.9448726390573559 1.0 0.9994590995170168 99.99999970742145 GOTERM_MF_FAT GO:0031420~alkali metal ion binding 12 1.0714285714285714 0.7323310506599846 SLC12A6, INPP1, SCN1A, SLC23A1, SLC12A2, SCN3A, SCN2A, SCN9A, SLC38A11, SCN7A, KCNV2, KCNG2 725 228 12983 0.9425045372050818 1.0 0.999533005442974 99.99999986793324 Annotation Cluster 62 Enrichment Score: 0.7068879332807038 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR004001:Actin, conserved site 4 0.35714285714285715 0.05473850463956089 ACTB, ACTC1, ACTR5, ACTL6B 920 16 16659 4.526902173913044 1.0 0.9870655185530421 60.158914189470636 INTERPRO IPR004000:Actin/actin-like 4 0.35714285714285715 0.36537810324594794 ACTB, ACTC1, ACTR5, ACTL6B 920 39 16659 1.857190635451505 1.0 0.9993707932311255 99.94090136111758 SMART SM00268:ACTIN 4 0.35714285714285715 0.37870475151304733 ACTB, ACTC1, ACTR5, ACTL6B 513 39 9079 1.8151646923576747 1.0 0.984641212625178 99.80983149357807 Annotation Cluster 63 Enrichment Score: 0.703022445514187 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001707~mesoderm formation 5 0.4464285714285714 0.13659761381226146 TBX6, TWSG1, NF2, HTT, BMPR2 751 36 13528 2.5018493860038467 1.0 0.9758076125253744 92.72248734241295 GOTERM_BP_FAT GO:0048332~mesoderm morphogenesis 5 0.4464285714285714 0.1574240930818083 TBX6, TWSG1, NF2, HTT, BMPR2 751 38 13528 2.37017310252996 1.0 0.9824666619803236 95.29246340943317 GOTERM_BP_FAT GO:0001704~formation of primary germ layer 5 0.4464285714285714 0.17933442787876092 TBX6, TWSG1, NF2, HTT, BMPR2 751 40 13528 2.2516644474034617 1.0 0.9840046750609639 97.05799935870924 GOTERM_BP_FAT GO:0048729~tissue morphogenesis 14 1.25 0.19963475368992217 TWSG1, TBX6, ACTC1, NF2, HTT, BMPR2, GREM1, SHANK3, VEGFC, LAMA1, BCL2, CASP8, COL1A2, TGIF1 751 180 13528 1.4010356561621542 1.0 0.9843271086894949 98.11821967435876 GOTERM_BP_FAT GO:0007498~mesoderm development 7 0.625 0.22647639962595484 TBX6, TWSG1, NF2, HTT, BMPR2, TBX1, JAK2 751 74 13528 1.703962284521539 1.0 0.9822255801103692 98.97609123190189 GOTERM_BP_FAT GO:0007369~gastrulation 6 0.5357142857142857 0.3470789235848293 TBX6, TWSG1, NF2, HTT, HIRA, BMPR2 751 70 13528 1.5439984782195169 1.0 0.9890153484787034 99.95023354441966 Annotation Cluster 64 Enrichment Score: 0.7012666744334303 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS cilium 8 0.7142857142857143 0.08365820385828039 BBS5, SLC25A31, BBS7, TTC21B, DNAH14, BBS9, SPAG4, DNAH7 1027 71 19235 2.11034463842451 1.0 0.6860864039531978 72.11806513255003 GOTERM_CC_FAT GO:0044441~cilium part 6 0.5357142857142857 0.09618418131063483 BBS5, BBS7, TTC21B, DNAH14, BBS9, DNAH7 713 44 12782 2.4446002805049085 1.0 0.7329053811755937 76.52478737225083 GOTERM_CC_FAT GO:0044463~cell projection part 18 1.607142857142857 0.1587550855016216 ALS2, CALCR, SCN1A, BBS5, BBS7, DNAH14, TTC21B, BBS9, DNAH7, MBP, MAPK1, PPP1R9A, TXNDC2, P2RX6, GHRH, SPAG4, CYBRD1, LRP2 713 234 12782 1.3790052864386664 1.0 0.8436248822451238 91.60324618306073 GOTERM_CC_FAT GO:0005930~axoneme 5 0.4464285714285714 0.19284310425899143 TXNDC2, TTC21B, DNAH14, SPAG4, DNAH7 713 41 12782 2.1862278931344714 1.0 0.8685268211067109 95.35833560442889 GOTERM_CC_FAT GO:0005929~cilium 10 0.8928571428571428 0.29162107201838416 BBS5, SLC25A31, BBS7, TTC21B, DNAH14, BBS9, SPAG4, CETN1, INHA, DNAH7 713 129 12782 1.3896952498994313 1.0 0.9197921852985017 99.2850888724288 GOTERM_CC_FAT GO:0035085~cilium axoneme 3 0.26785714285714285 0.40959147189336764 TTC21B, DNAH14, DNAH7 713 25 12782 2.15124824684432 1.0 0.9463583056016248 99.94745470742451 SP_PIR_KEYWORDS cell projection 13 1.1607142857142858 0.419198309268311 BBS5, ENAH, BBS7, NF2, DNAH14, TTC21B, BBS9, ABI2, DNAH7, RAPH1, SLC25A31, SPAG4, MAPT 1027 206 19235 1.1819466633894555 1.0 0.9094573147394461 99.96449000090377 Annotation Cluster 65 Enrichment Score: 0.6974493036656607 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051656~establishment of organelle localization 8 0.7142857142857143 0.08683753571460659 SEPT5, SNAP29, NDE1, BBS5, BBS7, SEH1L, CDC23, NDC80 751 69 13528 2.088500357011907 1.0 0.9693394869800066 80.22396076646136 GOTERM_BP_FAT GO:0051650~establishment of vesicle localization 4 0.35714285714285715 0.27582046409861966 SEPT5, SNAP29, BBS5, BBS7 751 33 13528 2.183432191421539 1.0 0.9838620344096096 99.68411984099707 GOTERM_BP_FAT GO:0051648~vesicle localization 4 0.35714285714285715 0.3375344566127625 SEPT5, SNAP29, BBS5, BBS7 751 37 13528 1.9473854680246159 1.0 0.9882369591368333 99.93552649686761 Annotation Cluster 66 Enrichment Score: 0.6938326648463032 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR001007:von Willebrand factor, type C 5 0.4464285714285714 0.17718482812495917 DGCR2, BMPER, ZAN, COL3A1, COL5A2 920 40 16659 2.2634510869565214 1.0 0.998341185956054 95.87533970843519 SMART SM00214:VWC 5 0.4464285714285714 0.1869002290953859 DGCR2, BMPER, ZAN, COL3A1, COL5A2 513 40 9079 2.2122319688109164 1.0 0.9765248554533 93.43545724920264 UP_SEQ_FEATURE domain:VWFC 3 0.26785714285714285 0.2503027609538955 DGCR2, COL3A1, COL5A2 1024 18 19113 3.11083984375 1.0 0.9999978710703087 99.39107624754556 Annotation Cluster 67 Enrichment Score: 0.6920048072158197 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:SCAN box 6 0.5357142857142857 0.1885292127545751 ZSCAN21, ZKSCAN1, ZNF394, SCAND1, ZNF496, ZKSCAN5 1024 57 19113 1.9647409539473686 1.0 0.999993830531873 97.52562986889654 INTERPRO IPR003309:Transcriptional regulator SCAN 6 0.5357142857142857 0.20490948353459737 ZSCAN21, ZKSCAN1, ZNF394, SCAND1, ZNF496, ZKSCAN5 920 57 16659 1.9060640732265444 1.0 0.9969414296219423 97.64472782532054 SMART SM00431:SCAN 6 0.5357142857142857 0.21729256454631646 ZSCAN21, ZKSCAN1, ZNF394, SCAND1, ZNF496, ZKSCAN5 513 57 9079 1.862932184261824 1.0 0.9753299738376789 96.02417423813036 Annotation Cluster 68 Enrichment Score: 0.6910872337396077 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0031985~Golgi cisterna 4 0.35714285714285715 0.12088306905258034 CHSY3, CHPF, GORASP2, AP4M1 713 22 12782 3.259467040673212 1.0 0.7889607527801852 84.21778138142282 GOTERM_CC_FAT GO:0031984~organelle subcompartment 4 0.35714285714285715 0.1466929030274961 CHSY3, CHPF, GORASP2, AP4M1 713 24 12782 2.9878447872837772 1.0 0.8386713077549324 89.70290521228972 GOTERM_CC_FAT GO:0005795~Golgi stack 4 0.35714285714285715 0.47639118617946263 CHSY3, CHPF, GORASP2, AP4M1 713 46 12782 1.558875541191536 1.0 0.9587802195744197 99.99059698043463 Annotation Cluster 69 Enrichment Score: 0.6878495052659902 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS GTP binding 7 0.625 0.14652557223527227 GNGT1, GNAL, RAB31, GNB2, RAC1, GNG11, SEPT7 1027 67 19235 1.9567934427182492 1.0 0.7646628862431222 90.13534178110032 SP_PIR_KEYWORDS nucleotide binding 9 0.8035714285714285 0.21162364203884257 GNAL, RAB31, MYO1B, RAC1, ABCB1, ABCC1, SEPT7, HNRNPU, ABCB4 1027 107 19235 1.5753624111603528 1.0 0.8249484618004294 96.9071398260533 SP_PIR_KEYWORDS P-loop 9 0.8035714285714285 0.27859535664538176 GNAL, RAB31, MYO1B, RAC1, ABCB1, ABCC1, SEPT7, HNRNPU, ABCB4 1027 116 19235 1.453136017191015 1.0 0.8496365253910055 99.15523837905074 Annotation Cluster 70 Enrichment Score: 0.6850149673950784 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS fatty acid metabolism 8 0.7142857142857143 0.04628293177282808 CPT1B, CHKB, SLC27A6, HSD17B4, LPIN2, HPGD, CROT, ACSL6, LPIN3 1027 62 19235 2.416684989163552 0.999999999996559 0.6104204522981256 49.98078773086421 SP_PIR_KEYWORDS lipid metabolism 11 0.9821428571428571 0.28632850825466716 MOGAT3, CPT1B, NAPEPLD, CHKB, SLC27A6, HSD17B4, LPIN2, HPGD, CROT, ACSL6, VLDLR, LPIN3 1027 151 19235 1.3643867240145215 1.0 0.8472483877096382 99.27837885718421 GOTERM_BP_FAT GO:0006631~fatty acid metabolic process 11 0.9821428571428571 0.6647672962205972 CPT1B, CHKB, PRKAB2, RNPEPL1, SLC27A6, HSD17B4, SCD5, FABP2, HPGD, CROT, ACSL6, DEGS1 751 198 13528 1.0007397544015386 1.0 0.997915354999373 99.99999965980874 Annotation Cluster 71 Enrichment Score: 0.6776371114859251 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA h_edg1Pathway:Phospholipids as signalling intermediaries 6 0.5357142857142857 0.009758200978551582 MAPK1, GNGT1, ITGAV, MAPK3, RAC1, SRC 87 23 1437 4.308845577211394 0.8448190782345215 0.6060699024376552 11.474251419458103 BIOCARTA h_pyk2Pathway:Links between Pyk2 and Map Kinases 6 0.5357142857142857 0.016549861812986233 MAPK1, CRKL, PLCG1, MAPK3, RAC1, SRC 87 26 1437 3.8116710875331563 0.9580293513644103 0.5473772069292941 18.731628877376984 UP_SEQ_FEATURE short sequence motif:TXY 4 0.35714285714285715 0.0233880446036934 MAPK1, MAPK12, MAPK3, MAPK11 1024 12 19113 6.2216796875 1.0 0.9999625351745725 34.2335111258238 INTERPRO IPR003527:MAP kinase, conserved site 4 0.35714285714285715 0.025315371141020726 MAPK1, MAPK12, MAPK3, MAPK11 920 12 16659 6.035869565217391 0.9999999999999976 0.9531423475534415 34.24117432894883 BIOCARTA h_biopeptidesPathway:Bioactive Peptide Induced Signaling Pathway 6 0.5357142857142857 0.029691825136705277 MAPK1, GNGT1, PLCG1, MAPT, MAPK3, JAK2 87 30 1437 3.303448275862069 0.9967428244687757 0.6818966573542972 31.24483501178418 KEGG_PATHWAY hsa04620:Toll-like receptor signaling pathway 12 1.0714285714285714 0.03458468795647166 TLR3, MAPK11, TLR5, STAT1, MAPK1, TMED7, MAPK12, RAC1, CASP8, MAPK3, TICAM2, LBP, AKT3 301 101 5085 2.007170816749449 0.9967758756780903 0.7617115759864017 34.71099558688543 KEGG_PATHWAY hsa04664:Fc epsilon RI signaling pathway 10 0.8928571428571428 0.03883070628201184 PDK1, CSF2, MAPK1, IL3, MAPK12, PLCG1, MAPK3, RAC1, MAPK11, AKT3 301 78 5085 2.1658573984155383 0.9984282562223147 0.7250356752494458 38.10553147371313 GOTERM_MF_FAT GO:0004707~MAP kinase activity 4 0.35714285714285715 0.03964950333463485 MAPK1, MAPK12, MAPK3, MAPK11 725 14 12983 5.116453201970443 0.9999999999999994 0.9326712576374246 46.61155782257863 BBID 54.T-cell_anergy 4 0.35714285714285715 0.04356799462527838 MAPK1, PLCG1, MAPK3, IL2 26 12 358 4.58974358974359 0.9309369050093479 0.9309369050093479 36.00855071451793 BIOCARTA h_fMLPpathway:fMLP induced chemokine gene expression in HMC-1 cells 5 0.4464285714285714 0.05767060833175213 MAPK1, GNGT1, MAPK3, RAC1, NFATC1 87 25 1437 3.3034482758620687 0.9999874535730762 0.8005708766430862 52.20579359327979 BIOCARTA h_pelp1Pathway:Pelp1 Modulation of Estrogen Receptor Activity 3 0.26785714285714285 0.061080272722849764 MAPK1, MAPK3, SRC 87 7 1437 7.078817733990147 0.9999936990192894 0.7761660190830797 54.31125921637317 BIOCARTA h_sam68Pathway:Regulation of Splicing through Sam68 3 0.26785714285714285 0.061080272722849764 MAPK1, MAPK3, SRC 87 7 1437 7.078817733990147 0.9999936990192894 0.7761660190830797 54.31125921637317 KEGG_PATHWAY hsa04370:VEGF signaling pathway 9 0.8035714285714285 0.07284686609926438 MAPK1, MAPK12, PLCG1, MAPK3, RAC1, MAPK11, SRC, AKT3, NFATC1 301 75 5085 2.0272425249169435 0.9999955772772885 0.8718805835425173 59.996347915701506 BIOCARTA h_At1rPathway:Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling 5 0.4464285714285714 0.07310763397158904 MAPK1, MAPK3, RAC1, SRC, ATF2 87 27 1437 3.05874840357599 0.9999994560386989 0.7986498300851808 61.075836025652144 BIOCARTA h_bArrestin-srcPathway:Roles of ???-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling 4 0.35714285714285715 0.08805856020258128 MAPK1, GNGT1, MAPK3, SRC 87 18 1437 3.6704980842911876 0.9999999752417068 0.7965207801979448 68.19877309205215 BIOCARTA h_sppaPathway:Aspirin Blocks Signaling Pathway Involved in Platelet Activation 4 0.35714285714285715 0.10021691128022858 MAPK1, GNGT1, MAPK3, SRC 87 19 1437 3.4773139745916515 0.9999999980671995 0.8121336843934284 73.08491118901192 KEGG_PATHWAY hsa04660:T cell receptor signaling pathway 11 0.9821428571428571 0.10301016356049586 PDK1, CSF2, MAPK1, MAPK12, PLCG1, MAPK3, MALT1, MAPK11, AKT3, IL2, NFATC1 301 108 5085 1.720653377630122 0.9999999798457743 0.860385807559944 73.2017485937378 BIOCARTA h_mPRPathway:How Progesterone Initiates the Oocyte Maturation 4 0.35714285714285715 0.11301026459801083 GNGT1, MAPK3, CDC25C, SRC 87 20 1437 3.3034482758620687 0.9999999998727866 0.8035821653375691 77.47321300928786 BIOCARTA h_gpcrPathway:Signaling Pathway from G-Protein Families 4 0.35714285714285715 0.1263924753140802 GNGT1, PLCG1, MAPK3, NFATC1 87 21 1437 3.1461412151067325 0.9999999999929188 0.7990297154068174 81.35155705634689 KEGG_PATHWAY hsa05212:Pancreatic cancer 8 0.7142857142857143 0.13025033218593085 MAPK1, VEGFC, RALBP1, MAPK3, RAC1, CDK6, STAT1, AKT3 301 72 5085 1.8770764119601329 0.9999999998677894 0.8261809368639124 81.55530339789607 KEGG_PATHWAY hsa04914:Progesterone-mediated oocyte maturation 9 0.8035714285714285 0.13299304447484128 MAPK1, MAD2L1, MAPK12, MAPK3, CDC23, MAPK11, CDC25C, CCNA2, AKT3 301 86 5085 1.767944062427567 0.9999999999209902 0.8101521114053718 82.24764476177991 BIOCARTA h_cxcr4Pathway:CXCR4 Signaling Pathway 4 0.35714285714285715 0.15473422512979323 MAPK1, GNGT1, PLCG1, MAPK3 87 23 1437 2.87256371814093 0.9999999999999866 0.8472284121953078 87.62269097484963 KEGG_PATHWAY hsa04621:NOD-like receptor signaling pathway 7 0.625 0.15685649928711598 MAPK1, MAPK12, MAPK3, CASP8, MAPK11, TRIP6, NLRP3 301 62 5085 1.90735183795949 0.9999999999991646 0.8241584525157934 87.34007832482979 KEGG_PATHWAY hsa04520:Adherens junction 8 0.7142857142857143 0.16708621441964588 ACTB, MAPK1, PTPRM, MAPK3, RAC1, YES1, CTNNA1, SRC 301 77 5085 1.755188333261423 0.9999999999998858 0.8267414806505536 89.0802270215838 BIOCARTA h_RacCycDPathway:Influence of Ras and Rho proteins on G1 to S Transition 4 0.35714285714285715 0.16959830777126805 MAPK1, MAPK3, RAC1, CDK6 87 24 1437 2.752873563218391 0.9999999999999996 0.8289046752098221 90.07197474987207 BIOCARTA h_erk5Pathway:Role of Erk5 in Neuronal Survival 3 0.26785714285714285 0.18022156427800698 MAPK1, PLCG1, MAPK3 87 13 1437 3.8116710875331563 1.0 0.8343624801058096 91.5400998482569 KEGG_PATHWAY hsa04722:Neurotrophin signaling pathway 11 0.9821428571428571 0.1947549964572577 PDK1, MAPK1, CRKL, MAPK12, PLCG1, BCL2, MAPK3, RAC1, SH2B2, MAPK11, AKT3 301 124 5085 1.4986335869681708 0.9999999999999996 0.8593544069397822 92.74748224395375 BIOCARTA h_bcrPathway:BCR Signaling Pathway 4 0.35714285714285715 0.20047605433480023 PLCG1, MAPK3, RAC1, NFATC1 87 26 1437 2.5411140583554377 1.0 0.8551837533773443 93.8009099701371 BIOCARTA h_barr-mapkPathway:Role of ???-arrestins in the activation and targeting of MAP kinases 3 0.26785714285714285 0.20248755754944353 MAPK1, GNGT1, MAPK3 87 14 1437 3.5394088669950734 1.0 0.8457354859106221 93.99198622594577 BIOCARTA h_agrPathway:Agrin in Postsynaptic Differentiation 4 0.35714285714285715 0.21639710688083713 MAPK1, MAPK3, RAC1, SRC 87 27 1437 2.446998722860792 1.0 0.8549246667159036 95.17209964757765 BIOCARTA h_spryPathway:Sprouty regulation of tyrosine kinase signals 3 0.26785714285714285 0.22505084799071623 MAPK1, MAPK3, SRC 87 15 1437 3.303448275862069 1.0 0.8559622342874407 95.79450433630426 GOTERM_BP_FAT GO:0007265~Ras protein signal transduction 9 0.8035714285714285 0.22657314751280977 MAPK1, CRKL, MAPK12, MAPK3, COL1A2, RAPGEF6, MAPK11, SRC, ELMO1 751 105 13528 1.5439984782195166 1.0 0.9818517012031401 98.97837362318278 KEGG_PATHWAY hsa05219:Bladder cancer 5 0.4464285714285714 0.2336721317326326 MAPK1, VEGFC, TYMP, FGFR3, MAPK3 301 42 5085 2.011153298528714 1.0 0.8608069961230242 96.01991137666455 BIOCARTA h_erkPathway:Erk1/Erk2 Mapk Signaling pathway 4 0.35714285714285715 0.24898045317229478 MAPK1, GNGT1, MAPK3, SRC 87 29 1437 2.2782401902497025 1.0 0.8766050099913009 97.15216550788278 BIOCARTA h_fcer1Pathway:Fc Epsilon Receptor I Signaling in Mast Cells 4 0.35714285714285715 0.2655576850731786 MAPK1, PLCG1, MAPK3, NFATC1 87 30 1437 2.2022988505747128 1.0 0.886043446571154 97.84207095224237 SP_PIR_KEYWORDS signal transduction 4 0.35714285714285715 0.28623883689483526 MAPK1, GNGT1, GNB2, MAPK3 1027 35 19235 2.1404924189734316 1.0 0.8500141698973522 99.27705222504574 BIOCARTA h_crebPathway:Transcription factor CREB and its extracellular signals 3 0.26785714285714285 0.2934478480488387 MAPK1, MAPK3, RAC1 87 18 1437 2.7528735632183907 1.0 0.9053030912948138 98.6662675294566 BIOCARTA h_malPathway:Role of MAL in Rho-Mediated Activation of SRF 3 0.26785714285714285 0.3161808994327358 MAPK1, MAPK3, RAC1 87 19 1437 2.607985480943739 1.0 0.9099201252383076 99.11173023248125 KEGG_PATHWAY hsa04666:Fc gamma R-mediated phagocytosis 8 0.7142857142857143 0.32779890484170465 ARPC1A, MAPK1, ARPC1B, CRKL, PLCG1, MAPK3, RAC1, AKT3 301 95 5085 1.422626333275048 1.0 0.8927427578130982 99.18629712608505 BIOCARTA h_integrinPathway:Integrin Signaling Pathway 4 0.35714285714285715 0.33285544830599323 MAPK1, CRKL, MAPK3, SRC 87 34 1437 1.9432048681541583 1.0 0.9163167835510166 99.34642720535652 BIOCARTA h_metPathway:Signaling of Hepatocyte Growth Factor Receptor 4 0.35714285714285715 0.33285544830599323 MAPK1, CRKL, MAPK3, SRC 87 34 1437 1.9432048681541583 1.0 0.9163167835510166 99.34642720535652 BIOCARTA h_tcrPathway:T Cell Receptor Signaling Pathway 4 0.35714285714285715 0.33285544830599323 PLCG1, MAPK3, RAC1, NFATC1 87 34 1437 1.9432048681541583 1.0 0.9163167835510166 99.34642720535652 BIOCARTA h_mapkPathway:MAPKinase Signaling Pathway 7 0.625 0.34416777910739044 MAPK1, MAPK12, MAPK3, RAC1, MAPK11, STAT1, ATF2 87 80 1437 1.4452586206896552 1.0 0.9118605417531702 99.47157410942393 BIOCARTA h_CCR3Pathway:CCR3 signaling in Eosinophils 3 0.26785714285714285 0.361109408003334 MAPK1, GNGT1, MAPK3 87 21 1437 2.3596059113300494 1.0 0.9182142838925001 99.61830449943051 KEGG_PATHWAY hsa05210:Colorectal cancer 7 0.625 0.37582178957977086 MAPK1, BCL2, MAPK3, RAC1, FZD1, AKT3, FZD7 301 84 5085 1.4078073089700998 1.0 0.9093530491275728 99.66846073723427 BIOCARTA h_ecmPathway:Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia 3 0.26785714285714285 0.3831887126887804 MAPK1, MAPK3, SRC 87 22 1437 2.2523510971786833 1.0 0.9274183496133456 99.75346428844685 BIOCARTA h_nfatPathway:NFAT and Hypertrophy of the heart (Transcription in the broken heart) 4 0.35714285714285715 0.3833969179146269 MAPK1, HAND2, MAPK3, NFATC1 87 37 1437 1.7856477166821993 1.0 0.9220714305962917 99.75449658632735 PIR_SUPERFAMILY PIRSF000564:kinase-related transforming protein 4 0.35714285714285715 0.38914680822811787 MAPK1, MAPK3, CDK6, CSNK1G3 395 42 7396 1.7832429174201327 1.0 0.9999983392858685 99.89064889576204 KEGG_PATHWAY hsa05223:Non-small cell lung cancer 5 0.4464285714285714 0.3956943004718002 MAPK1, PLCG1, MAPK3, CDK6, AKT3 301 54 5085 1.5642303433001108 1.0 0.9106038451875275 99.775962085279 KEGG_PATHWAY hsa05211:Renal cell carcinoma 6 0.5357142857142857 0.39732207929493635 MAPK1, VEGFC, CRKL, MAPK3, RAC1, AKT3 301 70 5085 1.4480303749406738 1.0 0.9054142442248413 99.78316368147692 KEGG_PATHWAY hsa05220:Chronic myeloid leukemia 6 0.5357142857142857 0.4565500575620446 MAPK1, CTBP1, CRKL, MAPK3, CDK6, AKT3 301 75 5085 1.3514950166112956 1.0 0.9062077803755983 99.9380647016023 KEGG_PATHWAY hsa04662:B cell receptor signaling pathway 6 0.5357142857142857 0.4565500575620446 MAPK1, MAPK3, RAC1, MALT1, AKT3, NFATC1 301 75 5085 1.3514950166112956 1.0 0.9062077803755983 99.9380647016023 KEGG_PATHWAY hsa05214:Glioma 5 0.4464285714285714 0.5147698734275943 MAPK1, PLCG1, MAPK3, CDK6, AKT3 301 63 5085 1.3407688656858092 1.0 0.9185595632655325 99.9843026388226 KEGG_PATHWAY hsa04062:Chemokine signaling pathway 12 1.0714285714285714 0.5499763148929393 MAPK1, GNGT1, CRKL, GNB2, MAPK3, RAC1, GRK4, JAK2, GNG11, STAT1, AKT3, ELMO1 301 187 5085 1.0840869117202905 1.0 0.9220684972960003 99.9936965918553 KEGG_PATHWAY hsa05120:Epithelial cell signaling in Helicobacter pylori infection 5 0.4464285714285714 0.5761283141450627 MAPK12, PLCG1, RAC1, MAPK11, SRC 301 68 5085 1.2421829196794998 1.0 0.9250450782780743 99.99694774439558 KEGG_PATHWAY hsa04012:ErbB signaling pathway 6 0.5357142857142857 0.5900082281588535 MAPK1, CRKL, PLCG1, MAPK3, SRC, AKT3 301 87 5085 1.1650819108718065 1.0 0.9253724694551382 99.99796073759441 KEGG_PATHWAY hsa05213:Endometrial cancer 4 0.35714285714285715 0.6001262246761752 MAPK1, MAPK3, CTNNA1, AKT3 301 52 5085 1.2995144390493227 1.0 0.9272824503790437 99.99849332988259 KEGG_PATHWAY hsa04150:mTOR signaling pathway 4 0.35714285714285715 0.6001262246761752 MAPK1, VEGFC, MAPK3, AKT3 301 52 5085 1.2995144390493227 1.0 0.9272824503790437 99.99849332988259 KEGG_PATHWAY hsa04540:Gap junction 6 0.5357142857142857 0.6104851667337421 GJD2, MAPK1, MAPK3, TUBB6, TUBA4A, SRC 301 89 5085 1.1389002948971592 1.0 0.9293306260791665 99.99890367098926 SP_PIR_KEYWORDS phosphotransferase 11 0.9821428571428571 0.6349236832640743 PDK1, MAPK1, FGFR3, MAPK12, MAPK3, PI4KA, CDK6, MAPK11, ITPKB, CLK1, SRC 1027 201 19235 1.0249870414238447 1.0 0.9617320270792075 99.99995995602559 KEGG_PATHWAY hsa04360:Axon guidance 8 0.7142857142857143 0.64611054337145 EPHA4, MAPK1, SEMA6A, PLXNB2, MAPK3, RAC1, EPHB4, NFATC1 301 129 5085 1.0476705555126324 1.0 0.9348433974702289 99.99965695629884 KEGG_PATHWAY hsa05218:Melanoma 4 0.35714285714285715 0.7990756452574354 MAPK1, MAPK3, CDK6, AKT3 301 71 5085 0.9517570539516168 1.0 0.9679971761199369 99.99999963900285 KEGG_PATHWAY hsa04650:Natural killer cell mediated cytotoxicity 7 0.625 0.8062622767298671 CSF2, MAPK1, PLCG1, MAPK3, RAC1, SH3BP2, NFATC1 301 133 5085 0.889141458296905 1.0 0.9676063096556315 99.99999976778372 KEGG_PATHWAY hsa04910:Insulin signaling pathway 7 0.625 0.8174646550451463 MAPK1, CRKL, PRKAB2, MAPK3, SH2B2, AKT3, G6PC2 301 135 5085 0.875968992248062 1.0 0.9700812289721362 99.99999988713529 SP_PIR_KEYWORDS serine/threonine-specific protein kinase 3 0.26785714285714285 0.8370651720749291 MAPK1, MAPK3, CDK6 1027 60 19235 0.9364654333008763 1.0 0.9907099640787124 99.99999999969764 KEGG_PATHWAY hsa04912:GnRH signaling pathway 5 0.4464285714285714 0.839180563039571 MAPK1, MAPK12, MAPK3, MAPK11, SRC 301 98 5085 0.8619228422265917 1.0 0.9758501315313224 99.99999997566503 KEGG_PATHWAY hsa05221:Acute myeloid leukemia 3 0.26785714285714285 0.8652213434806253 MAPK1, MAPK3, AKT3 301 58 5085 0.8738114331538549 1.0 0.9813852750915886 99.99999999713623 KEGG_PATHWAY hsa04010:MAPK signaling pathway 13 1.1607142857142858 0.8745695004250815 FGFR3, TAOK2, ZAK, MAPK11, ATF2, MAPK1, CRKL, MAPK12, MAPT, MAPK3, RAC1, MAPK8IP2, AKT3 301 267 5085 0.8225391018701705 1.0 0.9821978365950315 99.99999999880109 KEGG_PATHWAY hsa05215:Prostate cancer 4 0.35714285714285715 0.9039406396099899 MAPK1, BCL2, MAPK3, AKT3 301 89 5085 0.7592668632647729 1.0 0.9875913713401524 99.99999999995265 Annotation Cluster 72 Enrichment Score: 0.6754586861184206 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042522~regulation of tyrosine phosphorylation of Stat5 protein 6 0.5357142857142857 4.5786358750042134E-4 CSF2, IL3, NF2, JAK2, IL2, EPO 751 13 13528 8.313837959643552 0.7177349705420547 0.7177349705420547 0.8137308561776524 GOTERM_BP_FAT GO:0042523~positive regulation of tyrosine phosphorylation of Stat5 protein 5 0.4464285714285714 0.0015038570150597425 CSF2, IL3, JAK2, IL2, EPO 751 10 13528 9.006657789613847 0.9843420962975562 0.5645415488222298 2.6493180820106543 GOTERM_BP_FAT GO:0042509~regulation of tyrosine phosphorylation of STAT protein 6 0.5357142857142857 0.026477716268794065 CSF2, IL3, NF2, JAK2, IL2, EPO 751 31 13528 3.4864481766247155 1.0 0.9421936349309066 38.044538247658075 GOTERM_BP_FAT GO:0042531~positive regulation of tyrosine phosphorylation of STAT protein 5 0.4464285714285714 0.03577374097325148 CSF2, IL3, JAK2, IL2, EPO 751 23 13528 3.915938169397325 1.0 0.9569031016180732 47.79196570653965 GOTERM_BP_FAT GO:0046425~regulation of JAK-STAT cascade 6 0.5357142857142857 0.04691848013978986 CSF2, IL3, NF2, JAK2, IL2, EPO 751 36 13528 3.002219263204616 1.0 0.9607284615033269 57.57127237634894 GOTERM_BP_FAT GO:0046427~positive regulation of JAK-STAT cascade 5 0.4464285714285714 0.053049482815073906 CSF2, IL3, JAK2, IL2, EPO 751 26 13528 3.46409914985148 1.0 0.9673412804242849 62.18570397457718 BIOCARTA h_stemPathway:Regulation of hematopoiesis by cytokines 4 0.35714285714285715 0.055826169682913276 CSF2, IL3, IL2, EPO 87 15 1437 4.4045977011494255 0.999981808345731 0.8378269446396915 51.03002059731627 BIOCARTA h_erythPathway:Erythrocyte Differentiation Pathway 3 0.26785714285714285 0.18022156427800698 CSF2, IL3, EPO 87 13 1437 3.8116710875331563 1.0 0.8343624801058096 91.5400998482569 GOTERM_BP_FAT GO:0051054~positive regulation of DNA metabolic process 6 0.5357142857142857 0.1977277202689705 CSF2, IL3, BRCC3, FAM175A, IL2, EPO 751 56 13528 1.9299980977743958 1.0 0.984512621625945 98.03660037117544 SP_PIR_KEYWORDS pharmaceutical 5 0.4464285714285714 0.20629845570953326 CSF2, GHRH, F8, IL2, EPO 1027 44 19235 2.1283305302292646 1.0 0.8243220629756107 96.58728089581338 GOTERM_BP_FAT GO:0001934~positive regulation of protein amino acid phosphorylation 8 0.7142857142857143 0.2232336176159377 CSF2, VEGFC, IL3, BCL2, BMPR2, JAK2, IL2, EPO 751 89 13528 1.619174434087883 1.0 0.9826911473718664 98.89674561238907 GOTERM_BP_FAT GO:0050731~positive regulation of peptidyl-tyrosine phosphorylation 5 0.4464285714285714 0.26251415028267433 CSF2, IL3, JAK2, IL2, EPO 751 47 13528 1.9163101680029462 1.0 0.9838009811758658 99.56288194727257 GOTERM_BP_FAT GO:0042327~positive regulation of phosphorylation 8 0.7142857142857143 0.29164301977787294 CSF2, VEGFC, IL3, BCL2, BMPR2, JAK2, IL2, EPO 751 97 13528 1.4856342745754803 1.0 0.9854868297528886 99.78701211042893 GOTERM_BP_FAT GO:0048678~response to axon injury 3 0.26785714285714285 0.3052723359325553 BCL2, JAK2, EPO 751 20 13528 2.7019973368841543 1.0 0.986420887367379 99.849401625874 GOTERM_BP_FAT GO:0045937~positive regulation of phosphate metabolic process 8 0.7142857142857143 0.31846517890212356 CSF2, VEGFC, IL3, BCL2, BMPR2, JAK2, IL2, EPO 751 100 13528 1.4410652463382159 1.0 0.9874234374054248 99.89302882861598 GOTERM_BP_FAT GO:0010562~positive regulation of phosphorus metabolic process 8 0.7142857142857143 0.31846517890212356 CSF2, VEGFC, IL3, BCL2, BMPR2, JAK2, IL2, EPO 751 100 13528 1.4410652463382159 1.0 0.9874234374054248 99.89302882861598 GOTERM_BP_FAT GO:0050730~regulation of peptidyl-tyrosine phosphorylation 6 0.5357142857142857 0.32483136133259183 CSF2, IL3, NF2, JAK2, IL2, EPO 751 68 13528 1.5894101981671498 1.0 0.9880632980644617 99.90952038028445 GOTERM_BP_FAT GO:0001932~regulation of protein amino acid phosphorylation 12 1.0714285714285714 0.36407728510921333 CSF2, VEGFC, IL3, ZAK, NF2, BCL2, PSEN2, BMPR2, RAPGEF4, JAK2, IL2, EPO 751 173 13528 1.2494785372874702 1.0 0.9884993014371808 99.96891546198482 GOTERM_BP_FAT GO:0045597~positive regulation of cell differentiation 15 1.3392857142857142 0.3922179853616437 CSF2, PLXNB2, BMPR2, ITPKB, IL21, VEGFC, ADIG, MAPT, DLX5, BCL2, TGIF1, TGIF2, JAK2, IHH, IL2 751 229 13528 1.179911500822775 1.0 0.9899450537559844 99.986137113256 GOTERM_BP_FAT GO:0051052~regulation of DNA metabolic process 8 0.7142857142857143 0.44660782062010324 CSF2, IL3, CDC45, BRCC3, NF2, FAM175A, IL2, EPO 751 114 13528 1.264092321349312 1.0 0.9927185065449012 99.99739707278457 GOTERM_BP_FAT GO:0006275~regulation of DNA replication 5 0.4464285714285714 0.4526769537896687 CSF2, IL3, CDC45, NF2, EPO 751 62 13528 1.452686740260298 1.0 0.9928437410815578 99.99786195603494 GOTERM_BP_FAT GO:0045740~positive regulation of DNA replication 3 0.26785714285714285 0.46488239648518154 CSF2, IL3, EPO 751 28 13528 1.9299980977743958 1.0 0.9930054318474782 99.99857020628914 BIOCARTA h_inflamPathway:Cytokines and Inflammatory Response 3 0.26785714285714285 0.4679118298302691 CSF2, IL3, IL2 87 26 1437 1.9058355437665782 1.0 0.9537567526101114 99.96070381222097 SP_PIR_KEYWORDS T-cell 3 0.26785714285714285 0.4980175243676665 CSF2, IL3, IL2 1027 31 19235 1.812513741872664 1.0 0.9304580753023823 99.99578885201198 GOTERM_BP_FAT GO:0032270~positive regulation of cellular protein metabolic process 14 1.25 0.5315723358045052 CSF2, IL3, BTRC, BMPR2, CDC23, BOLL, VEGFC, MAPK1, KLKB1, BCL2, PSMC2, JAK2, EPO, IL2 751 233 13528 1.0823451420995183 1.0 0.9951551638729643 99.999866971025 GOTERM_BP_FAT GO:0031401~positive regulation of protein modification process 11 0.9821428571428571 0.592936115709401 CSF2, VEGFC, IL3, PSMC2, BCL2, BTRC, BMPR2, CDC23, JAK2, IL2, EPO 751 187 13528 1.0596067987780997 1.0 0.9962218737981918 99.9999891356165 GOTERM_BP_FAT GO:0051247~positive regulation of protein metabolic process 14 1.25 0.5935640549678306 CSF2, IL3, BTRC, BMPR2, CDC23, BOLL, VEGFC, MAPK1, KLKB1, BCL2, PSMC2, JAK2, EPO, IL2 751 243 13528 1.0378041897497439 1.0 0.9962107215624378 99.999989430769 GOTERM_BP_FAT GO:0031399~regulation of protein modification process 16 1.4285714285714286 0.673024094297307 CSF2, IL3, ZAK, NF2, BTRC, BMPR2, CDC23, VEGFC, MAD2L1, BCL2, PSMC2, PSEN2, RAPGEF4, JAK2, EPO, IL2 751 295 13528 0.9769933873479428 1.0 0.9980204910457836 99.999999781981 KEGG_PATHWAY hsa04630:Jak-STAT signaling pathway 9 0.8035714285714285 0.7039103621222071 CSF2, IL3, STAT4, JAK2, IL21, STAT1, AKT3, IL2, EPO 301 155 5085 0.9809238023791662 1.0 0.9435929889461139 99.99996044049804 GOTERM_BP_FAT GO:0032268~regulation of cellular protein metabolic process 25 2.232142857142857 0.7082798508161945 CSF2, ZAK, BTRC, BMPR2, ITGAV, BCL2, KLKB1, SERPINB10, RAPGEF4, EPO, IL3, NF2, PAIP2, CDC23, ETF1, BOLL, VEGFC, MAPK1, MAD2L1, EIF2AK1, PSMC2, PSEN2, JAK2, SRP9, IL2 751 474 13528 0.9500693870900684 1.0 0.998505658527549 99.9999999715235 INTERPRO IPR012351:Four-helical cytokine, core 3 0.26785714285714285 0.7294653246820955 CSF2, IL3, IL2 920 46 16659 1.180931001890359 1.0 0.9999969950146977 99.99999994774149 KEGG_PATHWAY hsa04640:Hematopoietic cell lineage 5 0.4464285714285714 0.7561194353225127 CSF2, IL3, ITGA6, GP1BB, EPO 301 86 5085 0.9821911457930929 1.0 0.9571804377598072 99.99999622633703 UP_SEQ_FEATURE glycosylation site:O-linked (GalNAc...) 4 0.35714285714285715 0.8764092096147494 CSF2, TFPI, IL2, EPO 1024 92 19113 0.8115234375 1.0 0.9999999999978776 99.99999999999999 KEGG_PATHWAY hsa04060:Cytokine-cytokine receptor interaction 8 0.7142857142857143 0.9960254910090014 CSF2, VEGFC, IL3, TNFRSF11A, BMPR2, IL21, IL2, EPO 301 262 5085 0.5158377925997312 1.0 0.9999239891004619 100.0 Annotation Cluster 73 Enrichment Score: 0.6717150684661815 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001654~eye development 11 0.9821428571428571 0.19685725551748856 GJA8, GNGT1, TWSG1, PTPRM, RAX, SP3, ABI2, TGIF1, TGIF2, COL5A2, CRYBA4 751 132 13528 1.501109631602308 1.0 0.9846373599922937 97.99824477253489 GOTERM_BP_FAT GO:0007423~sensory organ development 17 1.5178571428571428 0.2028220830867764 GJA8, TWSG1, RAX, PTPRM, MAFB, ABI2, TBX1, COL5A2, GNGT1, DLX6, SP3, BCL2, DLX5, TGIF1, TGIF2, CUX1, CRYBA4 751 229 13528 1.3372330342658116 1.0 0.9832949709761133 98.24752753851229 GOTERM_BP_FAT GO:0043010~camera-type eye development 9 0.8035714285714285 0.24187341123257064 GJA8, TWSG1, PTPRM, RAX, SP3, ABI2, TGIF1, TGIF2, CRYBA4 751 107 13528 1.5151386935798996 1.0 0.9821423423415365 99.28471875555167 Annotation Cluster 74 Enrichment Score: 0.6657313448848685 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:20 6 0.5357142857142857 0.06631585854345462 MUC3A, TXNDC2, NEFH, EWSR1, MUC17, MUC12 1024 41 19113 2.731469131097561 1.0 0.9999996171198247 70.32975692854384 UP_SEQ_FEATURE repeat:19 6 0.5357142857142857 0.07818891773762651 MUC3A, TXNDC2, NEFH, EWSR1, MUC17, MUC12 1024 43 19113 2.6044240552325584 1.0 0.9999916024634322 76.34610199294761 UP_SEQ_FEATURE repeat:18 6 0.5357142857142857 0.08452500123763872 MUC3A, TXNDC2, NEFH, EWSR1, MUC17, MUC12 1024 44 19113 2.5452325994318183 1.0 0.9999809150197226 79.06555171007619 UP_SEQ_FEATURE repeat:9 10 0.8928571428571428 0.10029841758293684 MUC3A, ENAH, TUBGCP6, TXNDC2, ADAM29, NEFH, CRIPAK, EWSR1, MUC17, MUC12 1024 103 19113 1.8121397148058254 1.0 0.9999595372920361 84.61113878841613 UP_SEQ_FEATURE repeat:28 4 0.35714285714285715 0.11060200558920948 NEFH, EWSR1, MUC17, MUC12 1024 22 19113 3.3936434659090913 1.0 0.9999708733150274 87.4504429204532 UP_SEQ_FEATURE repeat:17 6 0.5357142857142857 0.12785676910908877 MUC3A, TXNDC2, NEFH, EWSR1, MUC17, MUC12 1024 50 19113 2.2398046875 1.0 0.9999777235578684 91.12908284529357 UP_SEQ_FEATURE repeat:22 5 0.4464285714285714 0.1340450692468847 TXNDC2, NEFH, EWSR1, MUC17, MUC12 1024 37 19113 2.5223025760135136 1.0 0.9999757134116581 92.17997488038301 UP_SEQ_FEATURE repeat:27 4 0.35714285714285715 0.14722351595573438 NEFH, EWSR1, MUC17, MUC12 1024 25 19113 2.98640625 1.0 0.999985219775851 94.0395919353403 UP_SEQ_FEATURE repeat:21 5 0.4464285714285714 0.1539656851869014 TXNDC2, NEFH, EWSR1, MUC17, MUC12 1024 39 19113 2.3929537259615388 1.0 0.9999845478792058 94.8211348623924 UP_SEQ_FEATURE repeat:26 4 0.35714285714285715 0.17351659165486716 NEFH, EWSR1, MUC17, MUC12 1024 27 19113 2.7651909722222223 1.0 0.9999919103642804 96.57676133858706 UP_SEQ_FEATURE repeat:16 6 0.5357142857142857 0.17929004330646583 MUC3A, TXNDC2, NEFH, EWSR1, MUC17, MUC12 1024 56 19113 1.9998256138392856 1.0 0.9999930273192584 96.97637235793141 UP_SEQ_FEATURE domain:SEA 3 0.26785714285714285 0.1901068575534391 MUC3A, MUC17, MUC12 1024 15 19113 3.7330078125 1.0 0.9999928216140932 97.60944363856603 UP_SEQ_FEATURE repeat:8 10 0.8928571428571428 0.19359279626622977 MUC3A, ENAH, TUBGCP6, TXNDC2, ADAM29, NEFH, CRIPAK, EWSR1, MUC17, MUC12 1024 120 19113 1.555419921875 1.0 0.9999906779420581 97.78523613256641 UP_SEQ_FEATURE repeat:25 4 0.35714285714285715 0.21509972985514833 NEFH, EWSR1, MUC17, MUC12 1024 30 19113 2.488671875 1.0 0.9999953161794585 98.62771369310288 UP_SEQ_FEATURE repeat:24 4 0.35714285714285715 0.21509972985514833 NEFH, EWSR1, MUC17, MUC12 1024 30 19113 2.488671875 1.0 0.9999953161794585 98.62771369310288 UP_SEQ_FEATURE repeat:30 3 0.26785714285714285 0.23009729231383255 NEFH, EWSR1, MUC17 1024 17 19113 3.2938304227941178 1.0 0.99999632087134 99.02482739180175 UP_SEQ_FEATURE repeat:6 11 0.9821428571428571 0.2363912789782167 MUC3A, ENAH, TUBGCP6, TXNDC2, ADAM29, NEFH, CRIPAK, MYOM1, EWSR1, MUC17, MUC12 1024 143 19113 1.4357722355769231 1.0 0.9999968590503969 99.15675179786268 UP_SEQ_FEATURE repeat:7 10 0.8928571428571428 0.2540869079421829 MUC3A, ENAH, TUBGCP6, TXNDC2, ADAM29, NEFH, CRIPAK, EWSR1, MUC17, MUC12 1024 129 19113 1.4469022529069768 1.0 0.9999978716593687 99.443265890143 UP_SEQ_FEATURE repeat:3 15 1.3392857142857142 0.2571557227513794 SRRD, ENAH, ADAM29, CRIPAK, VEGFC, MUC3A, TUBGCP6, TXNDC2, RYR3, NEFH, MYOM1, MUC17, EWSR1, MUC12, NFATC1 1024 214 19113 1.3082971305490654 1.0 0.9999972457851839 99.48246018030811 UP_SEQ_FEATURE repeat:23 4 0.35714285714285715 0.25848579599469335 NEFH, EWSR1, MUC17, MUC12 1024 33 19113 2.2624289772727275 1.0 0.9999968509774285 99.49862575664876 UP_SEQ_FEATURE repeat:4 13 1.1607142857142858 0.26960702049391483 ENAH, ADAM29, CRIPAK, VEGFC, MUC3A, TUBGCP6, TXNDC2, RYR3, NEFH, MYOM1, MUC17, EWSR1, MUC12 1024 182 19113 1.3332170758928572 1.0 0.9999962342656884 99.61633619758933 UP_SEQ_FEATURE repeat:15 6 0.5357142857142857 0.28848647457152776 MUC3A, TXNDC2, NEFH, EWSR1, MUC17, MUC12 1024 67 19113 1.6714960354477613 1.0 0.9999958284274505 99.75869979458037 UP_SEQ_FEATURE repeat:29 3 0.26785714285714285 0.2907849863225447 NEFH, EWSR1, MUC17 1024 20 19113 2.7997558593750003 1.0 0.9999938436072899 99.77213656121276 UP_SEQ_FEATURE repeat:1 16 1.4285714285714286 0.3253841254160074 SRRD, ENAH, ADAM29, CRIPAK, VEGFC, MUC3A, TUBGCP6, TXNDC2, RYR3, NEFH, SERPIND1, MYOM1, MUC17, EWSR1, MUC12, NFATC1 1024 243 19113 1.228973765432099 1.0 0.9999981659784222 99.90601746139824 UP_SEQ_FEATURE repeat:2 16 1.4285714285714286 0.3315477426184072 SRRD, ENAH, ADAM29, CRIPAK, VEGFC, MUC3A, TUBGCP6, TXNDC2, RYR3, NEFH, SERPIND1, MYOM1, MUC17, EWSR1, MUC12, NFATC1 1024 246 19113 1.2139862804878048 1.0 0.9999977624449223 99.92011543740865 UP_SEQ_FEATURE repeat:5 11 0.9821428571428571 0.3319594731932573 MUC3A, ENAH, TUBGCP6, TXNDC2, ADAM29, NEFH, CRIPAK, MYOM1, EWSR1, MUC17, MUC12 1024 157 19113 1.307741590366242 1.0 0.9999974237183462 99.92098225082879 INTERPRO IPR000082:SEA 3 0.26785714285714285 0.34446998334290113 MUC3A, MUC17, MUC12 920 22 16659 2.4692193675889325 1.0 0.9992543307236836 99.89960488928914 SMART SM00200:SEA 3 0.26785714285714285 0.35455886450644486 MUC3A, MUC17, MUC12 513 22 9079 2.4133439659755447 1.0 0.9835340640451303 99.68587461505423 UP_SEQ_FEATURE repeat:14 6 0.5357142857142857 0.36319741956845863 MUC3A, TXNDC2, NEFH, EWSR1, MUC17, MUC12 1024 74 19113 1.5133815456081081 1.0 0.9999979604561682 99.96615865743726 UP_SEQ_FEATURE repeat:10 7 0.625 0.389618551020384 MUC3A, TXNDC2, NEFH, CRIPAK, EWSR1, MUC17, MUC12 1024 94 19113 1.3899497174202127 1.0 0.9999980564480914 99.98402021825167 UP_SEQ_FEATURE repeat:13 6 0.5357142857142857 0.40623267942316016 MUC3A, TXNDC2, NEFH, EWSR1, MUC17, MUC12 1024 78 19113 1.4357722355769231 1.0 0.9999981594566509 99.99019725232168 UP_SEQ_FEATURE repeat:12 6 0.5357142857142857 0.42763195273506505 MUC3A, TXNDC2, NEFH, EWSR1, MUC17, MUC12 1024 80 19113 1.3998779296875001 1.0 0.9999977151509187 99.99488227692049 UP_SEQ_FEATURE repeat:11 6 0.5357142857142857 0.4803300895977088 MUC3A, TXNDC2, NEFH, EWSR1, MUC17, MUC12 1024 85 19113 1.3175321691176471 1.0 0.9999994731223456 99.99907467805765 Annotation Cluster 75 Enrichment Score: 0.6357459042305053 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001947~heart looping 4 0.35714285714285715 0.11962626040693587 BBS5, BBS7, HAND2, TBX20 751 22 13528 3.2751482871323088 1.0 0.9714064937460164 89.70070464043107 GOTERM_BP_FAT GO:0035239~tube morphogenesis 10 0.8928571428571428 0.27194674888812903 BBS5, BBS7, HAND2, BCL2, TBX20, CASP8, TGIF1, GREM1, SHANK3, IHH 751 127 13528 1.4183713054509997 1.0 0.9839963203626834 99.65257743421132 GOTERM_BP_FAT GO:0003007~heart morphogenesis 6 0.5357142857142857 0.38058519457777285 ACTC1, BBS5, BBS7, HAND2, TBX20, TBX1 751 73 13528 1.4805464859639204 1.0 0.9895575142188829 99.9805575287798 Annotation Cluster 76 Enrichment Score: 0.6318714679818244 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0017124~SH3 domain binding 9 0.8035714285714285 0.16636537813021146 ENAH, TP53BP2, BAIAP2L1, MAPT, ABI2, LRP2, SHANK3, SH3BP2, ELMO1 725 96 12983 1.6788362068965517 1.0 0.9806291252969558 94.05487464742764 SP_PIR_KEYWORDS sh3-binding 6 0.5357142857142857 0.2249992962397592 ENAH, TP53BP2, LRP2, SHANK3, SH3BP2, ELMO1 1027 61 19235 1.842227081903363 1.0 0.8267069737534871 97.5916471572016 UP_SEQ_FEATURE short sequence motif:SH3-binding 5 0.4464285714285714 0.33973593407442126 TP53BP2, LRP2, SHANK3, SH3BP2, ELMO1 1024 55 19113 1.6968217329545454 1.0 0.99999756019745 99.93577853068443 Annotation Cluster 77 Enrichment Score: 0.6299856297076457 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE DNA-binding region:T-box 3 0.26785714285714285 0.21000617503107583 TBX6, TBX20, TBX1 1024 16 19113 3.49969482421875 1.0 0.9999948809114606 98.46117761525099 INTERPRO IPR001699:Transcription factor, T-box 3 0.26785714285714285 0.24059334615333738 TBX6, TBX20, TBX1 920 17 16659 3.1954603580562657 1.0 0.9987590418850757 98.88818476972305 INTERPRO IPR018186:Transcription factor, T-box, conserved site 3 0.26785714285714285 0.24059334615333738 TBX6, TBX20, TBX1 920 17 16659 3.1954603580562657 1.0 0.9987590418850757 98.88818476972305 SMART SM00425:TBOX 3 0.26785714285714285 0.24846097868998013 TBX6, TBX20, TBX1 513 17 9079 3.1231510147918815 1.0 0.9794438927701566 97.67124389593297 Annotation Cluster 78 Enrichment Score: 0.6241770192014753 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0050727~regulation of inflammatory response 9 0.8035714285714285 0.0588652717985745 AOAH, KLKB1, TGM2, TAC1, CHRNA7, JAK2, CALCRL, LBP, IL2 751 76 13528 2.133155792276964 1.0 0.9695294270939832 66.12160920984243 GOTERM_BP_FAT GO:0050728~negative regulation of inflammatory response 4 0.35714285714285715 0.2453656722812405 AOAH, CHRNA7, CALCRL, IL2 751 31 13528 2.3242987844164773 1.0 0.982204817845849 99.3412772635567 GOTERM_BP_FAT GO:0032101~regulation of response to external stimulus 12 1.0714285714285714 0.26744622307743016 F11, AOAH, KLKB1, SERPINE1, TGM2, TAC1, CHRNA7, JAK2, CALCRL, LBP, GREM1, IL2 751 159 13528 1.3594955154134112 1.0 0.9836389145279211 99.61220074479174 GOTERM_BP_FAT GO:0032102~negative regulation of response to external stimulus 5 0.4464285714285714 0.3001964328976009 AOAH, CHRNA7, CALCRL, GREM1, IL2 751 50 13528 1.8013315579227698 1.0 0.9859904298040922 99.82851523778635 GOTERM_BP_FAT GO:0031348~negative regulation of defense response 4 0.35714285714285715 0.3220749149897021 AOAH, CHRNA7, CALCRL, IL2 751 36 13528 2.0014795088030772 1.0 0.9877246963956805 99.902698545993 GOTERM_BP_FAT GO:0048585~negative regulation of response to stimulus 7 0.625 0.4815773259205166 AIDA, AOAH, COL3A1, CHRNA7, CALCRL, GREM1, IL2 751 100 13528 1.260932090545939 1.0 0.9937083716997132 99.9991877530511 Annotation Cluster 79 Enrichment Score: 0.6223285401925188 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0046879~hormone secretion 6 0.5357142857142857 0.10199373402603615 HTT, GHRH, MC4R, RAPGEF4, LRP2, VGF 751 45 13528 2.401775410563693 1.0 0.9721213056379714 85.32902427536213 GOTERM_BP_FAT GO:0009914~hormone transport 6 0.5357142857142857 0.1336146384052389 HTT, GHRH, MC4R, RAPGEF4, LRP2, VGF 751 49 13528 2.205712111742167 1.0 0.9778307645809532 92.26061850994137 GOTERM_BP_FAT GO:0030072~peptide hormone secretion 5 0.4464285714285714 0.16825245860016524 HTT, GHRH, MC4R, RAPGEF4, VGF 751 39 13528 2.30939943323432 1.0 0.9840269833257305 96.26257993026721 GOTERM_BP_FAT GO:0015833~peptide transport 6 0.5357142857142857 0.17840917535562695 HTT, DISP1, GHRH, MC4R, RAPGEF4, VGF 751 54 13528 2.0014795088030777 1.0 0.9846269749974524 96.9982569041437 GOTERM_BP_FAT GO:0030073~insulin secretion 4 0.35714285714285715 0.18649429452494828 HTT, MC4R, RAPGEF4, VGF 751 27 13528 2.66863934507077 1.0 0.9839338083980474 97.48378934825249 GOTERM_BP_FAT GO:0002790~peptide secretion 5 0.4464285714285714 0.19065231224939572 HTT, GHRH, MC4R, RAPGEF4, VGF 751 41 13528 2.1967458023448407 1.0 0.9841331399108887 97.70362705688565 GOTERM_BP_FAT GO:0003001~generation of a signal involved in cell-cell signaling 8 0.7142857142857143 0.1913905813017831 SEPT5, DOC2A, HTT, GHRH, MC4R, RAPGEF4, LRP2, VGF 751 85 13528 1.6953708780449597 1.0 0.9839507551179114 97.74071285740126 GOTERM_BP_FAT GO:0032940~secretion by cell 14 1.25 0.3620941455024773 SNAP29, SEPT5, CPLX4, HTT, NLRP3, VGF, MIA3, DOC2A, TRIM36, GHRH, MC4R, RAPGEF4, STEAP2, LRP2 751 207 13528 1.2182918749236122 1.0 0.9885129757042405 99.96713982625533 GOTERM_BP_FAT GO:0040014~regulation of multicellular organism growth 5 0.4464285714285714 0.4402075660676469 GHRH, BCL2, MC4R, AFG3L2, VGF 751 61 13528 1.4765012769858765 1.0 0.9926686151826412 99.99680434483778 GOTERM_BP_FAT GO:0010817~regulation of hormone levels 10 0.8928571428571428 0.4608707929602465 HTT, GHRH, MC4R, DHRS9, RAPGEF4, SCG5, RELN, COMT, LRP2, VGF 751 151 13528 1.1929348065713705 1.0 0.9928880699341566 99.99836641130454 GOTERM_BP_FAT GO:0046903~secretion 16 1.4285714285714286 0.6977398707172824 SNAP29, SEPT5, CPLX4, HTT, NLRP3, VGF, AGXT, MIA3, DOC2A, TRIM36, GHRH, MC4R, RAPGEF4, NEDD4L, STEAP2, LRP2 751 300 13528 0.9607101642254772 1.0 0.9984064618420166 99.99999994635922 Annotation Cluster 80 Enrichment Score: 0.6157699595896243 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0046605~regulation of centrosome cycle 3 0.26785714285714285 0.06879770406522681 PLK4, CEP76, RANBP1 751 8 13528 6.754993342210386 1.0 0.9644498661223166 71.9640108276302 GOTERM_BP_FAT GO:0032886~regulation of microtubule-based process 6 0.5357142857142857 0.1336146384052389 PLK4, CEP120, CEP76, MAPT, RANBP1, TACC3 751 49 13528 2.205712111742167 1.0 0.9778307645809532 92.26061850994137 GOTERM_BP_FAT GO:0070507~regulation of microtubule cytoskeleton organization 4 0.35714285714285715 0.4140669122585251 PLK4, CEP76, MAPT, RANBP1 751 42 13528 1.7155538646883521 1.0 0.991325357664011 99.99278584307227 GOTERM_BP_FAT GO:0010564~regulation of cell cycle process 8 0.7142857142857143 0.44660782062010324 PLK4, MAD2L1, PSMG2, CEP76, CDC23, RANBP1, ANLN, CDC25C 751 114 13528 1.264092321349312 1.0 0.9927185065449012 99.99739707278457 GOTERM_BP_FAT GO:0010638~positive regulation of organelle organization 6 0.5357142857142857 0.49059753828727765 PLK4, NF2, MAPT, RAC1, TAC1, RANBP1 751 83 13528 1.302167391269472 1.0 0.9939285171970772 99.99940613550633 Annotation Cluster 81 Enrichment Score: 0.612807539780928 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0019209~kinase activator activity 5 0.4464285714285714 0.047708370369673736 ALS2, CDK5R2, MAPK8IP2, MALT1, IL2 725 25 12983 3.58151724137931 1.0 0.9173451545466031 53.1536481109172 GOTERM_MF_FAT GO:0030295~protein kinase activator activity 3 0.26785714285714285 0.26555573033642405 ALS2, CDK5R2, MAPK8IP2 725 18 12983 2.9845977011494256 1.0 0.9908554253352713 99.16683949029085 GOTERM_MF_FAT GO:0019207~kinase regulator activity 7 0.625 0.4176534843890966 ALS2, CDK5R2, PRKRIP1, MAPK8IP2, MALT1, RAPGEF4, IL2 725 93 12983 1.34788283277716 1.0 0.9959742100718059 99.97722536507398 GOTERM_MF_FAT GO:0019887~protein kinase regulator activity 5 0.4464285714285714 0.6686571184823196 ALS2, CDK5R2, PRKRIP1, MAPK8IP2, RAPGEF4 725 81 12983 1.1054065559812687 1.0 0.9993681399351173 99.99999638209198 Annotation Cluster 82 Enrichment Score: 0.6090438457967009 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:WD 6 15 1.3392857142857142 0.1494599338582501 SEC31A, GNB1L, BTRC, HIRA, ARPC1A, WDR75, ARPC1B, DMXL1, GNB2, WDR17, WDR26, SEH1L, WDR64, WDR12, DYNC1I2 1024 192 19113 1.4582061767578125 1.0 0.9999834329642385 94.31039844024444 INTERPRO IPR017986:WD40 repeat, region 18 1.607142857142857 0.16628799647949832 SEC31A, GNB1L, BTRC, HIRA, ARPC1A, WDR75, ARPC1B, DMXL1, WDR17, GNB2, WDR26, SEH1L, FBXW4, WDR64, WDR12, LRWD1, NBEAL1, DYNC1I2 920 238 16659 1.3694830105955427 1.0 0.9984255195191714 94.88559622133431 INTERPRO IPR019781:WD40 repeat, subgroup 18 1.607142857142857 0.1832154457421839 SEC31A, GNB1L, BTRC, HIRA, ARPC1A, WDR75, ARPC1B, DMXL1, WDR17, GNB2, WDR26, SEH1L, FBXW4, WDR64, WDR12, LRWD1, NBEAL1, DYNC1I2 920 242 16659 1.3468469277757815 1.0 0.9982122221574182 96.34269647909905 INTERPRO IPR019782:WD40 repeat 2 17 1.5178571428571428 0.18404808086472965 SEC31A, GNB1L, BTRC, HIRA, ARPC1A, WDR75, ARPC1B, DMXL1, WDR17, GNB2, WDR26, SEH1L, FBXW4, WDR64, WDR12, LRWD1, NBEAL1 920 226 16659 1.3620767602924202 1.0 0.9979923506506329 96.40317072757331 UP_SEQ_FEATURE repeat:WD 1 19 1.6964285714285714 0.2190539440459197 SEC31A, GNB1L, BTRC, HIRA, ARPC1A, WDR75, KIAA1432, ARPC1B, DMXL1, WDR17, GNB2, WDR26, SEH1L, FBXW4, WDR64, WDR12, LRWD1, NBEAL1, DYNC1I2 1024 274 19113 1.294291029881387 1.0 0.9999953858524636 98.74511275219277 UP_SEQ_FEATURE repeat:WD 2 19 1.6964285714285714 0.2190539440459197 SEC31A, GNB1L, BTRC, HIRA, ARPC1A, WDR75, KIAA1432, ARPC1B, DMXL1, WDR17, GNB2, WDR26, SEH1L, FBXW4, WDR64, WDR12, LRWD1, NBEAL1, DYNC1I2 1024 274 19113 1.294291029881387 1.0 0.9999953858524636 98.74511275219277 SP_PIR_KEYWORDS wd repeat 19 1.6964285714285714 0.21922328130365343 SEC31A, GNB1L, BTRC, HIRA, ARPC1A, WDR75, KIAA1432, ARPC1B, DMXL1, WDR17, GNB2, WDR26, SEH1L, FBXW4, WDR64, WDR12, LRWD1, NBEAL1, DYNC1I2 1027 276 19235 1.2893364661388877 1.0 0.8253187436623051 97.31550572515968 UP_SEQ_FEATURE repeat:WD 5 16 1.4285714285714286 0.2670483545371457 SEC31A, GNB1L, BTRC, HIRA, ARPC1A, WDR75, ARPC1B, DMXL1, WDR17, GNB2, WDR26, SEH1L, WDR64, WDR12, LRWD1, DYNC1I2 1024 233 19113 1.2817194206008584 1.0 0.9999970762069521 99.59182767149682 INTERPRO IPR019775:WD40 repeat, conserved site 19 1.6964285714285714 0.2676480342777565 SEC31A, GNB1L, BTRC, HIRA, AHCTF1, ARPC1A, WDR75, KIAA1432, ARPC1B, WDR17, GNB2, WDR26, SEH1L, FBXW4, WDR64, WDR12, LRWD1, NBEAL1, DYNC1I2 920 277 16659 1.24203814157903 1.0 0.998774960059842 99.38555616485264 UP_SEQ_FEATURE repeat:WD 4 17 1.5178571428571428 0.2737170764906622 SEC31A, GNB1L, BTRC, HIRA, ARPC1A, WDR75, ARPC1B, DMXL1, WDR17, GNB2, WDR26, SEH1L, FBXW4, WDR64, WDR12, LRWD1, DYNC1I2 1024 251 19113 1.2641659922808766 1.0 0.99999560209483 99.65282019866262 INTERPRO IPR015943:WD40/YVTN repeat-like 20 1.7857142857142856 0.2978485040194331 GNB1L, BTRC, PLXNB2, HIRA, ARPC1A, WDR75, SEMA6A, KIAA1432, ARPC1B, DMXL1, WDR26, WDR17, GNB2, SEH1L, FBXW4, WDR64, WDR12, LRWD1, NBEAL1, DYNC1I2 920 300 16659 1.2071739130434782 1.0 0.9986833175253969 99.69132683281983 INTERPRO IPR001680:WD40 repeat 18 1.607142857142857 0.2981212660900598 SEC31A, GNB1L, BTRC, HIRA, ARPC1A, WDR75, ARPC1B, DMXL1, WDR17, GNB2, WDR26, SEH1L, FBXW4, WDR64, WDR12, LRWD1, NBEAL1, DYNC1I2 920 266 16659 1.2253269042170647 1.0 0.9985647379046088 99.69328123632451 SMART SM00320:WD40 18 1.607142857142857 0.33178829544909216 SEC31A, GNB1L, BTRC, HIRA, ARPC1A, WDR75, ARPC1B, DMXL1, WDR17, GNB2, WDR26, SEH1L, FBXW4, WDR64, WDR12, LRWD1, NBEAL1, DYNC1I2 513 266 9079 1.1975992613111726 1.0 0.985265618888104 99.50419916711016 UP_SEQ_FEATURE repeat:WD 3 17 1.5178571428571428 0.34994333379489473 SEC31A, GNB1L, BTRC, HIRA, ARPC1A, WDR75, ARPC1B, DMXL1, WDR17, GNB2, WDR26, SEH1L, FBXW4, WDR64, WDR12, LRWD1, DYNC1I2 1024 265 19113 1.1973798643867923 1.0 0.999997602069762 99.95126235769288 UP_SEQ_FEATURE repeat:WD 7 10 0.8928571428571428 0.41150147703561607 WDR75, DMXL1, SEC31A, GNB2, WDR17, BTRC, WDR64, HIRA, WDR12, DYNC1I2 1024 150 19113 1.2443359375 1.0 0.9999972492035555 99.99162848137667 Annotation Cluster 83 Enrichment Score: 0.5846446122015084 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051047~positive regulation of secretion 11 0.9821428571428571 0.08015421927889256 SEPT5, VEGFC, ACHE, CAPN10, GHRH, NNAT, TAC1, JAK2, INHA, NLRP3, IL2 751 109 13528 1.8178575355183912 1.0 0.9712811205147995 77.47622971587703 GOTERM_BP_FAT GO:0002793~positive regulation of peptide secretion 4 0.35714285714285715 0.1322041383236578 CAPN10, GHRH, NNAT, JAK2 751 23 13528 3.1327505355178604 1.0 0.9776830735063082 92.03271526188209 GOTERM_BP_FAT GO:0046887~positive regulation of hormone secretion 5 0.4464285714285714 0.13659761381226146 CAPN10, GHRH, NNAT, JAK2, INHA 751 36 13528 2.5018493860038467 1.0 0.9758076125253744 92.72248734241295 GOTERM_BP_FAT GO:0032024~positive regulation of insulin secretion 3 0.26785714285714285 0.26334319804522643 CAPN10, NNAT, JAK2 751 18 13528 3.002219263204616 1.0 0.9833917920438355 99.57156628706772 GOTERM_BP_FAT GO:0046883~regulation of hormone secretion 6 0.5357142857142857 0.30274741765076346 CAPN10, GHRH, NNAT, SCG5, JAK2, INHA 751 66 13528 1.6375741435661542 1.0 0.9860833559609836 99.83933199332252 GOTERM_BP_FAT GO:0002791~regulation of peptide secretion 4 0.35714285714285715 0.47321150705057435 CAPN10, GHRH, NNAT, JAK2 751 46 13528 1.5663752677589302 1.0 0.9933628548354431 99.99891925394545 GOTERM_BP_FAT GO:0051050~positive regulation of transport 13 1.1607142857142858 0.5848082063909185 SEPT5, ACHE, NNAT, TAC1, INHA, NLRP3, VEGFC, CAPN10, GHRH, JAK2, NEDD4L, TRIP6, IL2 751 223 13528 1.0501035987890586 1.0 0.9960852765188306 99.99998454066017 GOTERM_BP_FAT GO:0050796~regulation of insulin secretion 3 0.26785714285714285 0.6585022200966021 CAPN10, NNAT, JAK2 751 40 13528 1.3509986684420772 1.0 0.9977706214315416 99.99999952664024 Annotation Cluster 84 Enrichment Score: 0.5725451895921941 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007018~microtubule-based movement 12 1.0714285714285714 0.04866914382621216 KIF22, NDE1, KIF1A, HTT, DNAH14, TUBB6, TUBA4A, TUBA4B, DNAH7, DYNC1I2, KIF26B, KIF20A 751 113 13528 1.9129184685905518 1.0 0.9594321344234683 58.94040928160764 GOTERM_MF_FAT GO:0003777~microtubule motor activity 7 0.625 0.258480027844674 KIF22, KIF1A, DNAH14, DNAH7, DYNC1I2, KIF26B, KIF20A 725 77 12983 1.627962382445141 1.0 0.9910326549668913 99.03323367244347 UP_SEQ_FEATURE domain:Kinesin-motor 4 0.35714285714285715 0.40661002006804864 KIF22, KIF1A, KIF26B, KIF20A 1024 43 19113 1.7362827034883723 1.0 0.9999979407930867 99.99030697952365 INTERPRO IPR019821:Kinesin, motor region, conserved site 4 0.35714285714285715 0.41088928455423784 KIF22, KIF1A, KIF26B, KIF20A 920 42 16659 1.724534161490683 1.0 0.999718019977725 99.98249142790159 INTERPRO IPR001752:Kinesin, motor region 4 0.35714285714285715 0.41088928455423784 KIF22, KIF1A, KIF26B, KIF20A 920 42 16659 1.724534161490683 1.0 0.999718019977725 99.98249142790159 SMART SM00129:KISc 4 0.35714285714285715 0.4250308527874216 KIF22, KIF1A, KIF26B, KIF20A 513 42 9079 1.6855100714749836 1.0 0.9895554835342514 99.9314273986115 Annotation Cluster 85 Enrichment Score: 0.5643815590902236 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS amino-acid biosynthesis 4 0.35714285714285715 0.1336026708385943 PYCR2, ASNSD1, ASNS, ENOPH1 1027 24 19235 3.1215514443362546 1.0 0.7477277749630884 87.71165106335505 GOTERM_BP_FAT GO:0008652~cellular amino acid biosynthetic process 6 0.5357142857142857 0.15088297822135743 PYCR2, ASNSD1, ASNS, ENOPH1, CDO1, AGXT 751 51 13528 2.1192135975561994 1.0 0.9803217813561558 94.59603210378314 GOTERM_BP_FAT GO:0009067~aspartate family amino acid biosynthetic process 3 0.26785714285714285 0.20068299549505783 ASNSD1, ASNS, ENOPH1 751 15 13528 3.6026631158455396 1.0 0.9842706217035536 98.16170849218689 GOTERM_BP_FAT GO:0009064~glutamine family amino acid metabolic process 5 0.4464285714285714 0.3256583395960351 PYCR2, GLS, ASNSD1, ASNS, GAD1 751 52 13528 1.73204957492574 1.0 0.9880125791679204 99.91147732024697 GOTERM_BP_FAT GO:0046394~carboxylic acid biosynthetic process 11 0.9821428571428571 0.35724076737411825 PYCR2, HTT, PRKAB2, RNPEPL1, ASNSD1, ASNS, SCD5, ENOPH1, CDO1, AGXT, DEGS1 751 155 13528 1.2783643314290623 1.0 0.9885716533358778 99.96238183711007 GOTERM_BP_FAT GO:0016053~organic acid biosynthetic process 11 0.9821428571428571 0.35724076737411825 PYCR2, HTT, PRKAB2, RNPEPL1, ASNSD1, ASNS, SCD5, ENOPH1, CDO1, AGXT, DEGS1 751 155 13528 1.2783643314290623 1.0 0.9885716533358778 99.96238183711007 GOTERM_BP_FAT GO:0009066~aspartate family amino acid metabolic process 3 0.26785714285714285 0.3873428265619751 ASNSD1, ASNS, ENOPH1 751 24 13528 2.251664447403462 1.0 0.9899768849534346 99.98401340122311 GOTERM_BP_FAT GO:0009309~amine biosynthetic process 6 0.5357142857142857 0.46903128914295455 PYCR2, ASNSD1, ASNS, ENOPH1, CDO1, AGXT 751 81 13528 1.334319672535385 1.0 0.9931359207518544 99.99875558444647 Annotation Cluster 86 Enrichment Score: 0.5628476626240475 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY hsa04340:Hedgehog signaling pathway 7 0.625 0.11012931138301395 WNT10A, BTRC, CSNK1G3, LRP2, WNT6, WNT8A, IHH 301 56 5085 2.1117109634551494 0.9999999945009839 0.8225333228341072 75.66746719982541 SP_PIR_KEYWORDS wnt signaling pathway 11 0.9821428571428571 0.1166505297353731 WNT10A, BTRC, FBXW4, SFRP4, KREMEN1, FZD1, CSNK1G3, WNT6, WNT8A, FZD7, BCL9 1027 122 19235 1.688708158411416 1.0 0.7419624082005445 83.68759479771741 GOTERM_BP_FAT GO:0016055~Wnt receptor signaling pathway 11 0.9821428571428571 0.20311678560675717 WNT10A, BTRC, FBXW4, SFRP4, KREMEN1, FZD1, CSNK1G3, WNT6, WNT8A, FZD7, BCL9 751 133 13528 1.489823093018832 1.0 0.982958525724499 98.25905003701607 PIR_SUPERFAMILY PIRSF001784:int-1 transforming protein 3 0.26785714285714285 0.2687309501357192 WNT10A, WNT6, WNT8A 395 19 7396 2.956429047301799 1.0 0.9999786598199394 98.68249090101007 INTERPRO IPR018161:Secreted growth factor Wnt protein, conserved site 3 0.26785714285714285 0.28235845500665085 WNT10A, WNT6, WNT8A 920 19 16659 2.859096109839817 1.0 0.9990070420973196 99.5590170561346 INTERPRO IPR005817:Wnt superfamily 3 0.26785714285714285 0.28235845500665085 WNT10A, WNT6, WNT8A 920 19 16659 2.859096109839817 1.0 0.9990070420973196 99.5590170561346 INTERPRO IPR005816:Secreted growth factor Wnt protein 3 0.26785714285714285 0.28235845500665085 WNT10A, WNT6, WNT8A 920 19 16659 2.859096109839817 1.0 0.9990070420973196 99.5590170561346 SMART SM00097:WNT1 3 0.26785714285714285 0.29119900911404567 WNT10A, WNT6, WNT8A 513 19 9079 2.794398276392736 1.0 0.9858114832256079 98.92249278961181 GOTERM_BP_FAT GO:0007223~Wnt receptor signaling pathway, calcium modulating pathway 3 0.26785714285714285 0.3260881212751439 WNT10A, WNT6, WNT8A 751 21 13528 2.5733307970325283 1.0 0.9878826382571414 99.91247849890985 KEGG_PATHWAY hsa05217:Basal cell carcinoma 5 0.4464285714285714 0.4092905094808479 WNT10A, FZD1, WNT6, WNT8A, FZD7 301 55 5085 1.535789791603745 1.0 0.8954522794791174 99.82993692516284 KEGG_PATHWAY hsa04916:Melanogenesis 7 0.625 0.5339325674627906 WNT10A, MAPK1, MAPK3, FZD1, WNT6, WNT8A, FZD7 301 99 5085 1.1945031712473573 1.0 0.9251645737954465 99.99036486070726 KEGG_PATHWAY hsa04310:Wnt signaling pathway 10 0.8928571428571428 0.537687027431227 WNT10A, CTBP1, BTRC, SFRP4, RAC1, FZD1, WNT6, WNT8A, FZD7, NFATC1 301 151 5085 1.118787265406702 1.0 0.9191478411247856 99.99126408722161 Annotation Cluster 87 Enrichment Score: 0.5545745080068255 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS coated pit 5 0.4464285714285714 0.0886435327769227 AP1S1, AP4M1, LRP2, CLTCL1, VLDLR 1027 32 19235 2.9264544790652387 1.0 0.6911907723532884 74.25531341245836 GOTERM_CC_FAT GO:0005905~coated pit 6 0.5357142857142857 0.09618418131063483 AP1S1, AP4M1, HSPD1, LRP2, CLTCL1, VLDLR 713 44 12782 2.4446002805049085 1.0 0.7329053811755937 76.52478737225083 INTERPRO IPR000804:Clathrin adaptor, sigma subunit/coatomer, zeta subunit 3 0.26785714285714285 0.13919377835588823 AP1S1, AP3S1, AP4M1 920 12 16659 4.526902173913043 1.0 0.9974294631310744 91.37312168827751 GOTERM_CC_FAT GO:0030119~AP-type membrane coat adaptor complex 4 0.35714285714285715 0.23244970669449322 AP1S1, AP1B1, AP3S1, AP4M1 713 30 12782 2.3902758298270217 1.0 0.889536875811999 97.7429600534493 GOTERM_CC_FAT GO:0030117~membrane coat 6 0.5357142857142857 0.2732970528231804 AP1S1, SEC31A, AP1B1, AP3S1, AP4M1, CLTCL1 713 63 12782 1.7073398784478726 1.0 0.9067228478373294 98.96915292170243 GOTERM_CC_FAT GO:0048475~coated membrane 6 0.5357142857142857 0.2732970528231804 AP1S1, SEC31A, AP1B1, AP3S1, AP4M1, CLTCL1 713 63 12782 1.7073398784478726 1.0 0.9067228478373294 98.96915292170243 GOTERM_CC_FAT GO:0030118~clathrin coat 4 0.35714285714285715 0.37121289876982366 AP1S1, AP1B1, AP4M1, CLTCL1 713 39 12782 1.8386737152515553 1.0 0.9349664890769079 99.87043621526283 GOTERM_CC_FAT GO:0030131~clathrin adaptor complex 3 0.26785714285714285 0.4859012326223264 AP1S1, AP1B1, AP4M1 713 29 12782 1.854524350727862 1.0 0.9571727205209081 99.9927691039922 GOTERM_MF_FAT GO:0008565~protein transporter activity 6 0.5357142857142857 0.5380037008103361 AZGP1P1, AZGP1, AP1S1, AP1B1, SNX2, AP3S1, LRP2 725 87 12983 1.2350059453032105 1.0 0.9982983424766251 99.99937221645254 GOTERM_BP_FAT GO:0006898~receptor-mediated endocytosis 4 0.35714285714285715 0.5693919538771506 AP1S1, GRK4, LRP2, CLTCL1 751 53 13528 1.359495515413411 1.0 0.9957036194155368 99.99997037395654 KEGG_PATHWAY hsa04142:Lysosome 7 0.625 0.697177450687724 AP1S1, MFSD8, AP1B1, ARSA, AP3S1, AP4M1, CLTCL1 301 117 5085 1.0107334525939178 1.0 0.9429339747781884 99.99994805591395 Annotation Cluster 88 Enrichment Score: 0.5448305988645396 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030054~cell junction 40 3.571428571428571 0.03344406877475239 CPLX4, SNAP29, GJA8, SCN1A, ENAH, ACHE, VAPA, PANX2, GLRA3, CLDN5, ABI2, CLDN12, GJA5, GJC3, CLDN15, GRID2IP, OBSL1, CHRNA7, CHRNA1, GJD2, DLGAP1, PTPRM, NF2, ABCB11, SCN2A, ABCB1, CTNNA1, SHANK3, ABCB4, FMN1, EPB41L3, PPP1R9A, CHRM5, DOC2A, P2RX6, ITGA6, XIRP2, DOK7, TRIP6, STEAP1 713 518 12782 1.3843296311739508 0.9999999267788969 0.5602237078255694 38.58175607496186 SP_PIR_KEYWORDS cell junction 26 2.3214285714285716 0.22765101788308087 SNAP29, GJA8, CPLX4, ENAH, ACHE, PANX2, GLRA3, CLDN5, CLDN12, GJA5, GJC3, CLDN15, GRID2IP, CHRNA7, CHRNA1, GJD2, DLGAP1, CTNNA1, SHANK3, FMN1, CHRM5, PPP1R9A, DOC2A, XIRP2, DOK7, TRIP6 1027 399 19235 1.2204562038006408 1.0 0.8270369996753777 97.70934525101694 GOTERM_CC_FAT GO:0045202~synapse 23 2.0535714285714284 0.3341649373519563 CPLX4, ALS2, SNAP29, SEPT5, DLGAP1, ENAH, ACHE, SNCAIP, GLRA3, DLGAP4, SHANK3, SLC32A1, PPP1R9A, CHRM5, DOC2A, DES, P2RX6, DOK7, GRID2IP, CHRNA7, CHRNA1, GAD1, SLC40A1 713 355 12782 1.161472058155384 1.0 0.9321864621326466 99.7057069587078 SP_PIR_KEYWORDS synapse 14 1.25 0.34896175395906626 SNAP29, CPLX4, ACHE, ENAH, DLGAP1, GLRA3, SHANK3, CHRM5, PPP1R9A, DOC2A, DOK7, GRID2IP, CHRNA7, CHRNA1 1027 213 19235 1.2310343724142976 1.0 0.8816889808740231 99.81157655232674 GOTERM_CC_FAT GO:0044456~synapse part 15 1.3392857142857142 0.5097466432768557 ALS2, SEPT5, DLGAP1, SNCAIP, GLRA3, DLGAP4, SHANK3, SLC32A1, CHRM5, DOC2A, P2RX6, GRID2IP, CHRNA7, CHRNA1, SLC40A1 713 246 12782 1.0931139465672355 1.0 0.9599545947290768 99.99633887781779 SP_PIR_KEYWORDS postsynaptic cell membrane 7 0.625 0.5371006842166278 DLGAP1, CHRM5, GLRA3, GRID2IP, CHRNA7, CHRNA1, SHANK3 1027 110 19235 1.1918650969283882 1.0 0.9405455693452105 99.99871238427454 GOTERM_CC_FAT GO:0045211~postsynaptic membrane 8 0.7142857142857143 0.6316090049724821 DLGAP1, CHRM5, GLRA3, DLGAP4, GRID2IP, CHRNA7, CHRNA1, SHANK3 713 135 12782 1.0623448132564541 1.0 0.9665158108082536 99.9999390392547 Annotation Cluster 89 Enrichment Score: 0.5421173712199862 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR001300:Peptidase C2, calpain 3 0.26785714285714285 0.19916557223801218 CAPN10, CAPN8, CAPN2 920 15 16659 3.6215217391304346 1.0 0.9970688892748505 97.35060555376069 SMART SM00720:calpain_III 3 0.26785714285714285 0.20596239176724973 CAPN10, CAPN8, CAPN2 513 15 9079 3.5395711500974656 1.0 0.9801711177868314 95.19617689663824 SMART SM00230:CysPc 3 0.26785714285714285 0.20596239176724973 CAPN10, CAPN8, CAPN2 513 15 9079 3.5395711500974656 1.0 0.9801711177868314 95.19617689663824 GOTERM_MF_FAT GO:0004197~cysteine-type endopeptidase activity 7 0.625 0.21223189019040983 CASP10, CFLAR, CAPN10, CAPN8, CASP8, MALT1, CAPN2 725 72 12983 1.7410153256704983 1.0 0.9899088089903751 97.52877305808077 GOTERM_MF_FAT GO:0004198~calcium-dependent cysteine-type endopeptidase activity 3 0.26785714285714285 0.22338313997552375 CAPN10, CAPN8, CAPN2 725 16 12983 3.3576724137931038 1.0 0.990566645955627 98.01907665525161 INTERPRO IPR000169:Peptidase, cysteine peptidase active site 3 0.26785714285714285 0.5980866463844321 CAPN10, CAPN8, CAPN2 920 36 16659 1.5089673913043478 1.0 0.9999724210347241 99.99996623395975 SP_PIR_KEYWORDS thiol protease 7 0.625 0.6695193617099189 CASP10, CAPN10, UFSP2, CAPN8, CASP8, OTUD7A, CAPN2 1027 126 19235 1.040517148112085 1.0 0.9681058258901434 99.99999065775812 Annotation Cluster 90 Enrichment Score: 0.5420268326742296 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA h_TPOPathway:TPO Signaling Pathway 4 0.35714285714285715 0.11301026459801083 PLCG1, MAPK3, JAK2, STAT1 87 20 1437 3.3034482758620687 0.9999999998727866 0.8035821653375691 77.47321300928786 BIOCARTA h_pdgfPathway:PDGF Signaling Pathway 3 0.26785714285714285 0.4473398470998817 PLCG1, MAPK3, STAT1 87 25 1437 1.9820689655172412 1.0 0.948442628954062 99.93703393259644 BIOCARTA h_egfPathway:EGF Signaling Pathway 3 0.26785714285714285 0.4679118298302691 PLCG1, MAPK3, STAT1 87 26 1437 1.9058355437665782 1.0 0.9537567526101114 99.96070381222097 Annotation Cluster 91 Enrichment Score: 0.5306289572807965 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR015526:Frizzled related 3 0.26785714285714285 0.24059334615333738 SFRP4, FZD1, FZD7 920 17 16659 3.1954603580562657 1.0 0.9987590418850757 98.88818476972305 INTERPRO IPR000024:Frizzled cysteine-rich domain 3 0.26785714285714285 0.30319138703650256 SFRP4, FZD1, FZD7 920 20 16659 2.716141304347826 1.0 0.9986227888200117 99.72756152617909 UP_SEQ_FEATURE domain:FZ 3 0.26785714285714285 0.35084287079437515 SFRP4, FZD1, FZD7 1024 23 19113 2.4345703125 1.0 0.9999969103543479 99.95244287567957 Annotation Cluster 92 Enrichment Score: 0.5283214002013785 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048545~response to steroid hormone stimulus 15 1.3392857142857142 0.1795493580043187 CALCR, HMGB2, MSTN, CRIPAK, PTPRN, CDO1, AGXT, SRC, ABCB4, MAPK1, BCL2, ARSA, LOX, CCNA2, IHH 751 192 13528 1.4072902796271638 1.0 0.9835890195446874 97.07171558395991 GOTERM_BP_FAT GO:0031960~response to corticosteroid stimulus 7 0.625 0.33203504475376444 CALCR, BCL2, MSTN, CDO1, AGXT, SRC, ABCB4 751 85 13528 1.4834495182893397 1.0 0.9882078698563701 99.92527994892527 GOTERM_BP_FAT GO:0051384~response to glucocorticoid stimulus 6 0.5357142857142857 0.4361822806166731 CALCR, BCL2, MSTN, CDO1, AGXT, ABCB4 751 78 13528 1.3856396599405922 1.0 0.9925532564709083 99.99636858769404 Annotation Cluster 93 Enrichment Score: 0.525946578315447 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS myosin 6 0.5357142857142857 0.13450563254757664 MYO1B, MYO3B, MYH11, MYL12B, MYL12A, MYL9 1027 51 19235 2.2034480783550032 1.0 0.7442992814985063 87.8975515275046 GOTERM_CC_FAT GO:0016459~myosin complex 7 0.625 0.1526511421938067 MYO1B, MYO3B, MYH11, MYL12B, MYL12A, MYOM1, MYL9 713 65 12782 1.930607401014133 1.0 0.8444195502879884 90.68665165424251 INTERPRO IPR000048:IQ calmodulin-binding region 8 0.7142857142857143 0.20378253876885688 SCN1A, SCN3A, MYO1B, SCN2A, MYO3B, MYH11, SCN9A, SCN7A 920 87 16659 1.6650674662668665 1.0 0.9971682732061418 97.58955648167317 SMART SM00015:IQ 8 0.7142857142857143 0.21877978937046133 SCN1A, SCN3A, MYO1B, SCN2A, MYO3B, MYH11, SCN9A, SCN7A 513 87 9079 1.6273890345275706 1.0 0.9708279080604449 96.1224744049161 UP_SEQ_FEATURE domain:Myosin head-like 3 0.26785714285714285 0.5657627159753336 MYO1B, MYO3B, MYH11 1024 35 19113 1.5998604910714287 1.0 0.9999999370305898 99.99996153085335 INTERPRO IPR001609:Myosin head, motor region 3 0.26785714285714285 0.6277530912791587 MYO1B, MYO3B, MYH11 920 38 16659 1.4295480549199084 1.0 0.999984732383867 99.99999035992872 SMART SM00242:MYSc 3 0.26785714285714285 0.640230073172919 MYO1B, MYO3B, MYH11 513 38 9079 1.397199138196368 1.0 0.9979278703811899 99.9998568267186 Annotation Cluster 94 Enrichment Score: 0.5252453835972138 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS tyrosine-specific phosphatase 5 0.4464285714285714 0.08080883895094076 PTPRD, PTPRM, PTPN2, PTPRN, CDC25C 1027 31 19235 3.0208562364544402 1.0 0.6906669559727594 70.8234332629662 GOTERM_MF_FAT GO:0016791~phosphatase activity 20 1.7857142857142856 0.10517559678172339 PHLPP1, INPP1, IMPA2, PTPRD, PTPRM, PTPN2, ACP6, PTPRT, LPIN2, PTPRN, CDC25C, G6PC2, LPIN3, PPM1F, DUSP28, SBF1, PHOSPHO2, ENOPH1, PPP4C, CTDP1 725 249 12983 1.4383603379033374 1.0 0.959707614331706 82.16192149292736 UP_SEQ_FEATURE domain:Tyrosine-protein phosphatase 2 3 0.26785714285714285 0.13246406285625856 PTPRD, PTPRM, PTPRT 1024 12 19113 4.666259765625 1.0 0.9999795897633352 91.923268800267 UP_SEQ_FEATURE domain:Tyrosine-protein phosphatase 1 3 0.26785714285714285 0.13246406285625856 PTPRD, PTPRM, PTPRT 1024 12 19113 4.666259765625 1.0 0.9999795897633352 91.923268800267 INTERPRO IPR000242:Protein-tyrosine phosphatase, receptor/non-receptor type 5 0.4464285714285714 0.17718482812495917 PTPRD, PTPRM, PTPN2, PTPRT, PTPRN 920 40 16659 2.2634510869565214 1.0 0.998341185956054 95.87533970843519 SMART SM00194:PTPc 5 0.4464285714285714 0.1869002290953859 PTPRD, PTPRM, PTPN2, PTPRT, PTPRN 513 40 9079 2.2122319688109164 1.0 0.9765248554533 93.43545724920264 GOTERM_BP_FAT GO:0006470~protein amino acid dephosphorylation 11 0.9821428571428571 0.20311678560675717 PPM1F, DUSP28, PTPRD, PTPRM, SBF1, PTPN2, BCL2, PTPRT, PTPRN, CDC25C, CTDP1 751 133 13528 1.489823093018832 1.0 0.982958525724499 98.25905003701607 SP_PIR_KEYWORDS protein phosphatase 10 0.8928571428571428 0.2580204241729706 PHLPP1, PPM1F, DUSP28, PTPRD, PTPRM, PTPN2, PTPRT, CDC25C, PPP4C, CTDP1 1027 130 19235 1.4407160512321175 1.0 0.8390522915223766 98.72569065179282 GOTERM_MF_FAT GO:0019198~transmembrane receptor protein phosphatase activity 3 0.26785714285714285 0.26555573033642405 PTPRD, PTPRM, PTPRN 725 18 12983 2.9845977011494256 1.0 0.9908554253352713 99.16683949029085 SP_PIR_KEYWORDS phosphoric monoester hydrolase 6 0.5357142857142857 0.3071181828056176 PTPRD, PTPRM, PTPN2, PTPRN, CDC25C, PPP4C 1027 69 19235 1.628635536175437 1.0 0.862493923587053 99.53160236336682 GOTERM_MF_FAT GO:0004721~phosphoprotein phosphatase activity 12 1.0714285714285714 0.3145989953297943 PHLPP1, PPM1F, DUSP28, PTPRD, PTPRM, SBF1, PTPN2, PTPRT, PTPRN, CDC25C, PPP4C, CTDP1 725 165 12983 1.302369905956113 1.0 0.9907090872525056 99.71480348439465 GOTERM_BP_FAT GO:0016311~dephosphorylation 11 0.9821428571428571 0.3497714882176984 PPM1F, DUSP28, PTPRD, PTPRM, SBF1, PTPN2, BCL2, PTPRT, PTPRN, CDC25C, CTDP1 751 154 13528 1.286665398516264 1.0 0.989114767601599 99.95377063673779 UP_SEQ_FEATURE active site:Phosphocysteine intermediate 6 0.5357142857142857 0.4594205466153167 DUSP28, PTPRD, PTPRM, PTPN2, PTPRT, PTPRN 1024 83 19113 1.3492799322289157 1.0 0.9999990058088455 99.99813939459492 INTERPRO IPR000387:Protein-tyrosine phosphatase 6 0.5357142857142857 0.46460348300254845 DUSP28, PTPRD, PTPRM, PTPN2, PTPRT, PTPRN 920 81 16659 1.3413043478260869 1.0 0.999865807541475 99.99633163867726 INTERPRO IPR000387:Dual-specific/protein-tyrosine phosphatase, conserved region 6 0.5357142857142857 0.4753913538942552 DUSP28, PTPRD, PTPRM, PTPN2, PTPRT, PTPRN 920 82 16659 1.3249469777306468 1.0 0.9998891952260573 99.99736999279583 GOTERM_MF_FAT GO:0004725~protein tyrosine phosphatase activity 7 0.625 0.5259330684205363 DUSP28, PTPRD, PTPRM, PTPN2, PTPRT, PTPRN, CDC25C 725 104 12983 1.205318302387268 1.0 0.9981319511664255 99.99906337769518 INTERPRO IPR016130:Protein-tyrosine phosphatase, active site 6 0.5357142857142857 0.5485658282764125 DUSP28, PTPRD, PTPRM, PTPN2, PTPRT, PTPRN 920 89 16659 1.2207376648754276 1.0 0.9999520503335576 99.99977435946025 UP_SEQ_FEATURE domain:Fibronectin type-III 4 4 0.35714285714285715 0.6519233759101682 PTPRD, PTPRM, PTPRT, MYOM1 1024 62 19113 1.2041960685483872 1.0 0.9999999838388378 99.99999923390406 UP_SEQ_FEATURE domain:Fibronectin type-III 3 4 0.35714285714285715 0.8281832032633714 PTPRD, PTPRM, PTPRT, MYOM1 1024 83 19113 0.8995199548192772 1.0 0.9999999999492708 99.99999999999714 UP_SEQ_FEATURE domain:Tyrosine-protein phosphatase 3 0.26785714285714285 0.8516414096795544 DUSP28, PTPN2, PTPRN 1024 62 19113 0.9031470514112904 1.0 0.9999999999846817 99.99999999999979 Annotation Cluster 95 Enrichment Score: 0.5246087307210526 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009069~serine family amino acid metabolic process 4 0.35714285714285715 0.17240077394888698 NFS1, CDO1, AGXT, GLDC 751 26 13528 2.771279319881184 1.0 0.985225647256458 96.58153483081125 INTERPRO IPR015421:Pyridoxal phosphate-dependent transferase, major region, subdomain 1 5 0.4464285714285714 0.18839863192086587 AADAT, NFS1, AGXT, GAD1, GLDC 920 41 16659 2.2082449628844114 1.0 0.9974157927614367 96.70417764246596 SP_PIR_KEYWORDS pyridoxal phosphate 6 0.5357142857142857 0.23491390413014818 AADAT, NFS1, PHOSPHO2, AGXT, GAD1, GLDC 1027 62 19235 1.812513741872664 1.0 0.823468820487057 98.00485520560048 GOTERM_MF_FAT GO:0070279~vitamin B6 binding 5 0.4464285714285714 0.3552957299145792 AADAT, NFS1, AGXT, GAD1, GLDC 725 54 12983 1.6581098339719027 1.0 0.9941598104115348 99.88965178531856 GOTERM_MF_FAT GO:0030170~pyridoxal phosphate binding 5 0.4464285714285714 0.3552957299145792 AADAT, NFS1, AGXT, GAD1, GLDC 725 54 12983 1.6581098339719027 1.0 0.9941598104115348 99.88965178531856 GOTERM_MF_FAT GO:0019842~vitamin binding 7 0.625 0.7389957846237286 AADAT, P4HA2, PLOD3, NFS1, AGXT, GAD1, GLDC 725 130 12983 0.9642546419098145 1.0 0.9995294690821861 99.99999991068431 Annotation Cluster 96 Enrichment Score: 0.5238373202413134 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009310~amine catabolic process 8 0.7142857142857143 0.14069426971911475 ACHE, GLS, HIBCH, COMT, CDO1, GAD1, GLDC, ENOSF1 751 78 13528 1.8475195465874563 1.0 0.977017084094058 93.3145320753631 GOTERM_BP_FAT GO:0009063~cellular amino acid catabolic process 6 0.5357142857142857 0.32483136133259183 GLS, HIBCH, CDO1, GAD1, GLDC, ENOSF1 751 68 13528 1.5894101981671498 1.0 0.9880632980644617 99.90952038028445 GOTERM_BP_FAT GO:0046395~carboxylic acid catabolic process 8 0.7142857142857143 0.4191391020306839 CPT1B, CHKB, GLS, HIBCH, HSD17B4, CDO1, GAD1, GLDC, ENOSF1 751 111 13528 1.2982569786830773 1.0 0.9918448207251498 99.99382239366066 GOTERM_BP_FAT GO:0016054~organic acid catabolic process 8 0.7142857142857143 0.4191391020306839 CPT1B, CHKB, GLS, HIBCH, HSD17B4, CDO1, GAD1, GLDC, ENOSF1 751 111 13528 1.2982569786830773 1.0 0.9918448207251498 99.99382239366066 Annotation Cluster 97 Enrichment Score: 0.5214661146331 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF002255:collagen alpha 1(I) chain 3 0.26785714285714285 0.025426438086664265 COL3A1, COL1A2, COL5A2 395 5 7396 11.234430379746835 0.9999408535714671 0.7511201196204613 29.97218706925171 UP_SEQ_FEATURE propeptide:C-terminal propeptide 3 0.26785714285714285 0.06463382783608126 COL3A1, COL1A2, COL5A2 1024 8 19113 6.9993896484375 1.0 0.9999998474795769 69.36890506049397 GOTERM_MF_FAT GO:0005201~extracellular matrix structural constituent 9 0.8035714285714285 0.10612569258624062 LAMA1, MUC3A, COL3A1, COL1A2, EMILIN2, WNT6, TFPI2, COL5A2, MUC17 725 86 12983 1.8740497193263832 1.0 0.9566177118437544 82.45346800275266 SP_PIR_KEYWORDS Ehlers-Danlos syndrome 3 0.26785714285714285 0.11362689848520618 COL3A1, COL1A2, COL5A2 1027 11 19235 5.107993272550234 1.0 0.7391153242418442 82.85203261782922 UP_SEQ_FEATURE domain:Fibrillar collagen NC1 3 0.26785714285714285 0.1142847264848825 COL3A1, COL1A2, COL5A2 1024 11 19113 5.090465198863637 1.0 0.9999711418782754 88.33943567872686 INTERPRO IPR000885:Fibrillar collagen, C-terminal 3 0.26785714285714285 0.12021404381515462 COL3A1, COL1A2, COL5A2 920 11 16659 4.938438735177865 1.0 0.9955934584254277 87.67766816700721 SMART SM00038:COLFI 3 0.26785714285714285 0.1246713261487474 COL3A1, COL1A2, COL5A2 513 11 9079 4.826687931951089 0.9999999999999998 0.973266524541169 82.67047042464351 GOTERM_CC_FAT GO:0005583~fibrillar collagen 3 0.26785714285714285 0.1414051368628812 COL3A1, COL1A2, COL5A2 713 12 12782 4.481767180925666 1.0 0.8340437133973868 88.74975327517012 GOTERM_BP_FAT GO:0030199~collagen fibril organization 4 0.35714285714285715 0.21550119930791434 COL3A1, COL1A2, LOX, COL5A2 751 29 13528 2.4845952523072685 1.0 0.9840462233185785 98.68348738439265 KEGG_PATHWAY hsa04512:ECM-receptor interaction 8 0.7142857142857143 0.2252991123558652 LAMA1, ITGA6, GP1BB, ITGAV, COL3A1, COL1A2, RELN, COL5A2 301 84 5085 1.6089226388229712 1.0 0.8751344781214104 95.45995530476668 SP_PIR_KEYWORDS pyroglutamic acid 5 0.4464285714285714 0.22913255741349012 AZGP1P1, AZGP1, COL3A1, RLN2, COL1A2, COL5A2 1027 46 19235 2.0357944202192964 1.0 0.8182875655483209 97.77274820778918 GOTERM_CC_FAT GO:0005581~collagen 4 0.35714285714285715 0.3091763140152463 COL3A1, COL1A2, LOX, COL5A2 713 35 12782 2.0488078541374475 1.0 0.922082714261556 99.50103071078762 SP_PIR_KEYWORDS collagen 7 0.625 0.39614163746246134 EMID1, CCBE1, COL3A1, COL1A2, COLEC12, EMILIN2, COL5A2 1027 95 19235 1.3800543227591862 1.0 0.9000361509389216 99.93726422604122 SP_PIR_KEYWORDS trimer 3 0.26785714285714285 0.40735101590736766 COL3A1, COL1A2, COL5A2 1027 26 19235 2.1610740768481764 1.0 0.9046279259911103 99.95229614346097 GOTERM_BP_FAT GO:0043588~skin development 3 0.26785714285714285 0.4833550777522807 COL3A1, COL1A2, COL5A2 751 29 13528 1.8634464392304513 1.0 0.9936970108784132 99.99923603662074 INTERPRO IPR008160:Collagen triple helix repeat 6 0.5357142857142857 0.4967447103920529 EMID1, CCBE1, COL3A1, COL1A2, COLEC12, COL5A2 920 84 16659 1.2934006211180122 1.0 0.9999244210128863 99.99866669769426 SP_PIR_KEYWORDS triple helix 3 0.26785714285714285 0.4980175243676665 COL3A1, COL1A2, COL5A2 1027 31 19235 1.812513741872664 1.0 0.9304580753023823 99.99578885201198 SP_PIR_KEYWORDS hydroxylysine 3 0.26785714285714285 0.4980175243676665 COL3A1, COL1A2, COL5A2 1027 31 19235 1.812513741872664 1.0 0.9304580753023823 99.99578885201198 SP_PIR_KEYWORDS hydroxyproline 3 0.26785714285714285 0.5943670646298251 COL3A1, COL1A2, COL5A2 1027 37 19235 1.5185925945419616 1.0 0.9576128759794093 99.99981321389183 GOTERM_BP_FAT GO:0043062~extracellular structure organization 9 0.8035714285714285 0.6885903598767572 ALS2, ACHE, COL3A1, MYH11, COL1A2, LOX, CHRNA1, AFG3L2, COL5A2 751 163 13528 0.9946002467058236 1.0 0.9982846450084171 99.99999990868191 GOTERM_MF_FAT GO:0046332~SMAD binding 3 0.26785714285714285 0.7351773950536937 COL3A1, COL1A2, COL5A2 725 46 12983 1.1678860569715144 1.0 0.9995138520954607 99.99999988811513 GOTERM_CC_FAT GO:0044420~extracellular matrix part 6 0.5357142857142857 0.7875076617332144 LAMA1, ACHE, COL3A1, COL1A2, LOX, COL5A2 713 117 12782 0.9193368576257777 1.0 0.9889639906257179 99.99999997706047 GOTERM_BP_FAT GO:0030198~extracellular matrix organization 5 0.4464285714285714 0.8355175734589274 COL3A1, MYH11, COL1A2, LOX, COL5A2 751 104 13528 0.86602478746287 1.0 0.9997252001039699 99.99999999999896 SP_PIR_KEYWORDS hydroxylation 3 0.26785714285714285 0.8983858086757148 COL3A1, COL1A2, COL5A2 1027 71 19235 0.7913792394091912 1.0 0.9959680666941565 99.9999999999997 GOTERM_BP_FAT GO:0007398~ectoderm development 6 0.5357142857142857 0.9875900560126212 NF2, BCL2, PSEN2, COL3A1, COL1A2, COL5A2 751 199 13528 0.5431150425897798 1.0 0.999999951304455 100.0 GOTERM_BP_FAT GO:0008544~epidermis development 5 0.4464285714285714 0.9926375538382852 BCL2, PSEN2, COL3A1, COL1A2, COL5A2 751 184 13528 0.48949227117466565 1.0 0.9999999917076725 100.0 Annotation Cluster 98 Enrichment Score: 0.5184578681341652 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA h_badPathway:Regulation of BAD phosphorylation 4 0.35714285714285715 0.08805856020258128 MAPK1, IL3, BCL2, MAPK3 87 18 1437 3.6704980842911876 0.9999999752417068 0.7965207801979448 68.19877309205215 BIOCARTA h_ceramidePathway:Ceramide Signaling Pathway 4 0.35714285714285715 0.1263924753140802 MAPK1, BCL2, MAPK3, CASP8 87 21 1437 3.1461412151067325 0.9999999999929188 0.7990297154068174 81.35155705634689 KEGG_PATHWAY hsa05210:Colorectal cancer 7 0.625 0.37582178957977086 MAPK1, BCL2, MAPK3, RAC1, FZD1, AKT3, FZD7 301 84 5085 1.4078073089700998 1.0 0.9093530491275728 99.66846073723427 BIOCARTA h_keratinocytePathway:Keratinocyte Differentiation 3 0.26785714285714285 0.676232425674927 MAPK1, BCL2, MAPK3 87 38 1437 1.3039927404718694 1.0 0.9931464622526847 99.99991817812192 KEGG_PATHWAY hsa05215:Prostate cancer 4 0.35714285714285715 0.9039406396099899 MAPK1, BCL2, MAPK3, AKT3 301 89 5085 0.7592668632647729 1.0 0.9875913713401524 99.99999999995265 Annotation Cluster 99 Enrichment Score: 0.5165405219985925 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016701~oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 7 0.625 0.16927926797843026 P4HA2, PLOD3, MIOX, ASPHD1, KDM4C, KDM3B, CDO1 725 67 12983 1.8709418425115802 1.0 0.9801952681740252 94.36917891516217 SP_PIR_KEYWORDS dioxygenase 6 0.5357142857142857 0.27566928370116506 P4HA2, PLOD3, ASPHD1, KDM4C, KDM3B, CDO1 1027 66 19235 1.7026644241834115 1.0 0.8490657003163053 99.10374060130559 GOTERM_MF_FAT GO:0016702~oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 6 0.5357142857142857 0.30698019357986783 P4HA2, PLOD3, ASPHD1, KDM4C, KDM3B, CDO1 725 66 12983 1.6279623824451412 1.0 0.9913063704166455 99.66145466975779 UP_SEQ_FEATURE metal ion-binding site:Iron; catalytic 3 0.26785714285714285 0.38991614178854317 KDM4C, KDM3B, CDO1 1024 25 19113 2.2398046875 1.0 0.9999978057232672 99.98415761431416 GOTERM_MF_FAT GO:0016706~oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors 3 0.26785714285714285 0.46797609565580217 P4HA2, PLOD3, ASPHD1 725 28 12983 1.9186699507389164 1.0 0.9975519711994475 99.99439477672789 Annotation Cluster 100 Enrichment Score: 0.5107746229911454 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0050727~regulation of inflammatory response 9 0.8035714285714285 0.0588652717985745 AOAH, KLKB1, TGM2, TAC1, CHRNA7, JAK2, CALCRL, LBP, IL2 751 76 13528 2.133155792276964 1.0 0.9695294270939832 66.12160920984243 GOTERM_BP_FAT GO:0019725~cellular homeostasis 34 3.0357142857142856 0.08925489378050953 SRI, CALCR, ALDOA, FTMT, CLCN3, SCN1A, TFR2, TMX3, TAC1, BUD31, GJC3, MBP, BCL2, TGM2, CHRNA7, NEDD4L, CHRNA1, SCO2, GJD2, SLC12A6, AIFM3, SLC12A2, HTT, AFG3L2, ABCB6, TXNDC2, GHRH, RYR3, NAB1, TXNRD2, JAK2, SLC40A1, IL2, ADD1 751 466 13528 1.3142762439779865 1.0 0.9650409515309536 81.13743676321631 GOTERM_BP_FAT GO:0006873~cellular ion homeostasis 28 2.5 0.09862919318079787 CALCR, SRI, FTMT, CLCN3, SCN1A, TFR2, TAC1, BUD31, GJC3, MBP, BCL2, TGM2, CHRNA7, NEDD4L, CHRNA1, SCO2, SLC12A6, GJD2, AIFM3, HTT, AFG3L2, ABCB6, GHRH, RYR3, NAB1, JAK2, SLC40A1, IL2 751 374 13528 1.348590471172127 1.0 0.9697296464156424 84.3167927401772 GOTERM_BP_FAT GO:0055082~cellular chemical homeostasis 28 2.5 0.11282423588515281 CALCR, SRI, FTMT, CLCN3, SCN1A, TFR2, TAC1, BUD31, GJC3, MBP, BCL2, TGM2, CHRNA7, NEDD4L, CHRNA1, SCO2, SLC12A6, GJD2, AIFM3, HTT, AFG3L2, ABCB6, GHRH, RYR3, NAB1, JAK2, SLC40A1, IL2 751 380 13528 1.3272969374167778 1.0 0.9669161890671193 88.1847606353686 GOTERM_BP_FAT GO:0045822~negative regulation of heart contraction 3 0.26785714285714285 0.16001778417741222 TAC1, JAK2, IL2 751 13 13528 4.156918979821776 1.0 0.9819303419800376 95.54440576186273 GOTERM_BP_FAT GO:0050801~ion homeostasis 28 2.5 0.20174767200417965 CALCR, SRI, FTMT, CLCN3, SCN1A, TFR2, TAC1, BUD31, GJC3, MBP, BCL2, TGM2, CHRNA7, NEDD4L, CHRNA1, SCO2, SLC12A6, GJD2, AIFM3, HTT, AFG3L2, ABCB6, GHRH, RYR3, NAB1, JAK2, SLC40A1, IL2 751 409 13528 1.233185418626835 1.0 0.9837815984929803 98.20490684477058 GOTERM_BP_FAT GO:0050729~positive regulation of inflammatory response 4 0.35714285714285715 0.23034338770126905 TGM2, TAC1, JAK2, LBP 751 30 13528 2.401775410563693 1.0 0.9819992455462694 99.06366928169487 GOTERM_BP_FAT GO:0030003~cellular cation homeostasis 18 1.607142857142857 0.2517905063665504 SRI, CALCR, FTMT, CLCN3, TFR2, TAC1, ABCB6, BUD31, GHRH, RYR3, BCL2, TGM2, CHRNA7, JAK2, NEDD4L, SLC40A1, SCO2, IL2 751 254 13528 1.2765341749058998 1.0 0.9828696160243363 99.43447338003308 GOTERM_BP_FAT GO:0055066~di-, tri-valent inorganic cation homeostasis 17 1.5178571428571428 0.25278275047287585 SRI, CALCR, FTMT, HTT, TFR2, TAC1, ABCB6, BUD31, GHRH, RYR3, BCL2, TGM2, CHRNA7, JAK2, SLC40A1, SCO2, IL2 751 239 13528 1.2812818612839785 1.0 0.9828348336037281 99.4477053281723 GOTERM_BP_FAT GO:0030005~cellular di-, tri-valent inorganic cation homeostasis 16 1.4285714285714286 0.27797802469372657 SRI, CALCR, FTMT, TFR2, TAC1, ABCB6, BUD31, GHRH, RYR3, BCL2, TGM2, CHRNA7, JAK2, SLC40A1, SCO2, IL2 751 227 13528 1.2696610099896175 1.0 0.9841651465296615 99.7004954302451 GOTERM_BP_FAT GO:0042592~homeostatic process 46 4.107142857142857 0.31695664216740177 SRI, ALDOA, CALCR, FTMT, CLCN3, SCN1A, MAEA, TFR2, TMX3, TAC1, VGF, BUD31, GJC3, MBP, BHLHA15, BCL2, RAC1, SERPINE1, TGM2, CHRNA7, SH2B2, NEDD4L, CHRNA1, SCO2, EPO, GJD2, SLC12A6, AIFM3, SLC12A2, HTT, CIDEA, INHA, AFG3L2, ABCB6, MUC3A, TXNDC2, GHRH, SP3, RYR3, NAB1, TXNRD2, JAK2, PARP1, SLC40A1, ADD1, IL2 751 751 13528 1.10334556144404 1.0 0.9875612844779293 99.88872488626131 GOTERM_BP_FAT GO:0055080~cation homeostasis 19 1.6964285714285714 0.32906678210620244 SRI, CALCR, FTMT, CLCN3, HTT, TFR2, TAC1, ABCB6, BUD31, GHRH, RYR3, BCL2, TGM2, CHRNA7, JAK2, NEDD4L, SLC40A1, SCO2, IL2 751 286 13528 1.1966887972214204 1.0 0.987833859049444 99.9191291497369 GOTERM_BP_FAT GO:0048878~chemical homeostasis 31 2.767857142857143 0.4113603076095826 CALCR, SRI, FTMT, CLCN3, SCN1A, TFR2, TAC1, VGF, BUD31, GJC3, MBP, BHLHA15, BCL2, SERPINE1, TGM2, CHRNA7, NEDD4L, CHRNA1, SCO2, GJD2, SLC12A6, AIFM3, HTT, AFG3L2, ABCB6, GHRH, RYR3, NAB1, JAK2, SLC40A1, IL2 751 512 13528 1.0906499667110519 1.0 0.9913678633012032 99.99216760415044 GOTERM_BP_FAT GO:0007204~elevation of cytosolic calcium ion concentration 7 0.625 0.5756591074277878 CALCR, GHRH, TGM2, TAC1, JAK2, BUD31, IL2 751 110 13528 1.146301900496308 1.0 0.9958333384340993 99.99997719260386 GOTERM_BP_FAT GO:0051480~cytosolic calcium ion homeostasis 7 0.625 0.6443454597726423 CALCR, GHRH, TGM2, TAC1, JAK2, BUD31, IL2 751 118 13528 1.0685865174118125 1.0 0.9975489732698721 99.99999902295555 GOTERM_BP_FAT GO:0006875~cellular metal ion homeostasis 11 0.9821428571428571 0.6522588642962555 CALCR, GHRH, BCL2, RYR3, TGM2, TAC1, CHRNA7, JAK2, NEDD4L, BUD31, IL2 751 196 13528 1.0109513845484932 1.0 0.997648938306344 99.99999934601574 GOTERM_BP_FAT GO:0006874~cellular calcium ion homeostasis 10 0.8928571428571428 0.6916350562432776 CALCR, GHRH, BCL2, RYR3, TGM2, TAC1, CHRNA7, JAK2, BUD31, IL2 751 183 13528 0.9843341846572511 1.0 0.9983534945442657 99.99999992336477 GOTERM_BP_FAT GO:0032103~positive regulation of response to external stimulus 4 0.35714285714285715 0.6966201803615009 TGM2, TAC1, JAK2, LBP 751 64 13528 1.125832223701731 1.0 0.9984147694424113 99.99999994270132 GOTERM_BP_FAT GO:0055065~metal ion homeostasis 11 0.9821428571428571 0.7064438063401908 CALCR, GHRH, BCL2, RYR3, TGM2, TAC1, CHRNA7, JAK2, NEDD4L, BUD31, IL2 751 205 13528 0.96656815303173 1.0 0.9985119360702557 99.99999996815068 GOTERM_BP_FAT GO:0055074~calcium ion homeostasis 10 0.8928571428571428 0.721577985341973 CALCR, GHRH, BCL2, RYR3, TGM2, TAC1, CHRNA7, JAK2, BUD31, IL2 751 188 13528 0.9581550840014731 1.0 0.9985900520032207 99.99999998761267 GOTERM_BP_FAT GO:0060191~regulation of lipase activity 3 0.26785714285714285 0.9577224893073373 TGM2, JAK2, BUD31 751 87 13528 0.6211488130768171 1.0 0.9999965947186146 100.0 Annotation Cluster 101 Enrichment Score: 0.5097449832145899 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0046907~intracellular transport 47 4.196428571428571 0.06119411858693652 ALS2, ENAH, SEC31A, AP1B1, NAPG, CHKB, HPS4, SNX2, BET1, AP3S1, LMAN1, AGXT, AP1S1, NDE1, TRAK2, PEX1, BHLHA15, BCL2, VPS4B, RANBP1, SLC25A1, SCG5, TLK1, WIPF1, HSPA9, CPT1B, MCM3AP, KDELR2, ACTC1, TAOK2, HTT, PGAP1, MALT1, AP4M1, STRADB, SLC25A12, MAPK1, PHAX, KIF1A, NOP58, SIL1, JAK2, THOC5, LRP2, STEAP2, CUX1, CLTCL1, SRP9 751 657 13528 1.2886237933389677 1.0 0.9715442065626958 67.58649905526006 GOTERM_BP_FAT GO:0006886~intracellular protein transport 25 2.232142857142857 0.26305419721898154 NAPG, AP1B1, HPS4, SNX2, AP3S1, AGXT, AP1S1, PEX1, TRAK2, SCG5, TLK1, HSPA9, KDELR2, MCM3AP, TAOK2, HTT, PGAP1, STRADB, AP4M1, MAPK1, SIL1, NOP58, JAK2, CLTCL1, SRP9 751 374 13528 1.2040986349751135 1.0 0.9836342268041097 99.56855764135119 GOTERM_BP_FAT GO:0015031~protein transport 46 4.107142857142857 0.3525415215815807 SNAP29, SEC31A, AP1B1, NAPG, HPS4, SNX2, BET1, AP3S1, LMAN1, AGXT, AP1S1, MIA3, TRAK2, PEX1, SEH1L, RANBP6, VPS4B, SCG5, TLK1, SNX24, HSPA9, MCM3AP, KDELR2, ATG9A, RAB39B, TAOK2, HTT, PGAP1, SNX25, AP4M1, STRADB, NLRP3, MAPK1, PHAX, RAB31, CHMP1B, PSEN2, NOP58, SIL1, JAK2, RAB12, LRP2, CLTCL1, SRP9, MVP, KIF20A 751 762 13528 1.0874180008457663 1.0 0.989042113388938 99.95716100985518 GOTERM_BP_FAT GO:0045184~establishment of protein localization 46 4.107142857142857 0.3674503169650331 SNAP29, SEC31A, AP1B1, NAPG, HPS4, SNX2, BET1, AP3S1, LMAN1, AGXT, AP1S1, MIA3, TRAK2, PEX1, SEH1L, RANBP6, VPS4B, SCG5, TLK1, SNX24, HSPA9, MCM3AP, KDELR2, ATG9A, RAB39B, TAOK2, HTT, PGAP1, SNX25, AP4M1, STRADB, NLRP3, MAPK1, PHAX, RAB31, CHMP1B, PSEN2, NOP58, SIL1, JAK2, RAB12, LRP2, CLTCL1, SRP9, MVP, KIF20A 751 769 13528 1.077519527496065 1.0 0.9885517280349584 99.97172925670989 GOTERM_BP_FAT GO:0034613~cellular protein localization 25 2.232142857142857 0.4393252917016356 NAPG, AP1B1, HPS4, SNX2, AP3S1, AGXT, AP1S1, PEX1, TRAK2, SCG5, TLK1, HSPA9, KDELR2, MCM3AP, TAOK2, HTT, PGAP1, STRADB, AP4M1, MAPK1, SIL1, NOP58, JAK2, CLTCL1, SRP9 751 411 13528 1.0957004610235825 1.0 0.9926813697296283 99.99671328473181 SP_PIR_KEYWORDS protein transport 28 2.5 0.43990013096711555 SNAP29, SEC31A, NAPG, AP1B1, BET1, SNX2, AP3S1, AHCTF1, LMAN1, AP1S1, MIA3, PEX1, SEH1L, RANBP6, VPS4B, SNX24, KDELR2, ATG9A, RAB39B, PGAP1, SNX25, AP4M1, PHAX, CHMP1B, SIL1, RAB12, MVP, KIF20A 1027 485 19235 1.0812796755638985 1.0 0.9133523933448532 99.97911079361926 GOTERM_BP_FAT GO:0070727~cellular macromolecule localization 25 2.232142857142857 0.44255377136863816 NAPG, AP1B1, HPS4, SNX2, AP3S1, AGXT, AP1S1, PEX1, TRAK2, SCG5, TLK1, HSPA9, KDELR2, MCM3AP, TAOK2, HTT, PGAP1, STRADB, AP4M1, MAPK1, SIL1, NOP58, JAK2, CLTCL1, SRP9 751 414 13528 1.087760602610368 1.0 0.9925981664131328 99.99703505095493 GOTERM_BP_FAT GO:0008104~protein localization 51 4.553571428571428 0.4685651349828356 ALS2, SEC31A, AP1B1, HPS4, AP3S1, AGXT, AP1S1, TRAK2, PEX1, SEH1L, RANBP6, VPS4B, TLK1, MCM3AP, KDELR2, ATG9A, RAB39B, SGOL2, PGAP1, AP4M1, TACC3, NLRP3, MAPK1, CHMP1B, PSEN2, SIL1, RAB12, SRP9, MVP, SNAP29, NAPG, SNX2, BET1, LMAN1, MIA3, SCG5, SNX24, HSPA9, TAOK2, HTT, SNX25, NDC80, STRADB, GNGT1, PHAX, RAB31, NOP58, JAK2, LRP2, CLTCL1, KIF20A 751 882 13528 1.0415862749893565 1.0 0.9931858980701405 99.99873594822618 Annotation Cluster 102 Enrichment Score: 0.5032156487695322 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF800009:TGF-beta-like cysteine-knot cytokine 4 0.35714285714285715 0.09805193233879825 LEFTY2, MSTN, INHA, LEFTY1 395 21 7396 3.5664858348402655 1.0 0.9868893457754945 76.01070391904395 GOTERM_BP_FAT GO:0007179~transforming growth factor beta receptor signaling pathway 6 0.5357142857142857 0.23831043251648265 LEFTY2, COL3A1, COL1A2, MSTN, HPGD, LEFTY1 751 60 13528 1.8013315579227698 1.0 0.9816708277767885 99.22231090098451 INTERPRO IPR015615:Transforming growth factor-beta-related 4 0.35714285714285715 0.25814471461086064 LEFTY2, MSTN, INHA, LEFTY1 920 32 16659 2.263451086956522 1.0 0.9989701089461138 99.24139007649761 SP_PIR_KEYWORDS growth factor 10 0.8928571428571428 0.26511233206959506 CSF2, VEGFC, IL3, TYMP, LEFTY2, MSTN, INHA, VGF, LEFTY1, IL2 1027 131 19235 1.429718218779964 1.0 0.8419610113304069 98.89261246806034 INTERPRO IPR001111:Transforming growth factor beta (TGFb), N-terminal 3 0.26785714285714285 0.3239122272686463 LEFTY2, MSTN, LEFTY1 920 21 16659 2.5868012422360245 1.0 0.9990368291572153 99.83368047759556 INTERPRO IPR017948:Transforming growth factor beta, conserved site 4 0.35714285714285715 0.3346962982126366 LEFTY2, MSTN, INHA, LEFTY1 920 37 16659 1.9575793184488839 1.0 0.9991241361675699 99.87212519078562 INTERPRO IPR001839:Transforming growth factor beta 4 0.35714285714285715 0.3346962982126366 LEFTY2, MSTN, INHA, LEFTY1 920 37 16659 1.9575793184488839 1.0 0.9991241361675699 99.87212519078562 GOTERM_BP_FAT GO:0007178~transmembrane receptor protein serine/threonine kinase signaling pathway 8 0.7142857142857143 0.3456894499901396 TWSG1, LEFTY2, COL3A1, COL1A2, BMPR2, MSTN, HPGD, LEFTY1 751 103 13528 1.3990924721730251 1.0 0.9891481774598133 99.94830981228534 SMART SM00204:TGFB 4 0.35714285714285715 0.3473749924671896 LEFTY2, MSTN, INHA, LEFTY1 513 37 9079 1.913281702755387 1.0 0.9864197270683693 99.63660452568783 GOTERM_MF_FAT GO:0008083~growth factor activity 10 0.8928571428571428 0.5459751927882237 CSF2, VEGFC, IL3, TYMP, LEFTY2, MSTN, INHA, VGF, LEFTY1, IL2 725 161 12983 1.112272435210966 1.0 0.9984326362643456 99.99952075824604 GOTERM_MF_FAT GO:0005125~cytokine activity 10 0.8928571428571428 0.7662116262469362 CSF2, IL3, LEFTY2, MSTN, INHA, IL33, GREM1, IL21, LEFTY1, IL2 725 195 12983 0.9183377541998232 1.0 0.9997203885483066 99.99999998381683 Annotation Cluster 103 Enrichment Score: 0.5006083425829717 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0042641~actomyosin 4 0.35714285714285715 0.18829283584138473 ACTC1, MYH11, SH2B2, SEPT7 713 27 12782 2.6558620331411356 1.0 0.8667098668036872 94.9689325453065 GOTERM_CC_FAT GO:0001725~stress fiber 3 0.26785714285714285 0.3896412186362481 MYH11, SH2B2, SEPT7 713 24 12782 2.240883590462833 1.0 0.9415055200568749 99.91540243383918 GOTERM_CC_FAT GO:0032432~actin filament bundle 3 0.26785714285714285 0.42921637561925036 MYH11, SH2B2, SEPT7 713 26 12782 2.0685079296579993 1.0 0.9490169656767504 99.96762960011155 Annotation Cluster 104 Enrichment Score: 0.4978877952178958 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030097~hemopoiesis 20 1.7857142857142856 0.06579968037046795 EGR1, CALCR, CSF2, TWSG1, MAEA, CDK6, MALT1, ITPKB, INHA, TACC3, SP3, BCL2, PSEN2, CASP8, JAK2, SCAND1, NHEJ1, ADD1, IL2, EPO 751 236 13528 1.5265521677311609 1.0 0.9672243642029877 70.309234705546 GOTERM_BP_FAT GO:0002521~leukocyte differentiation 12 1.0714285714285714 0.11095963237858428 CALCR, EGR1, CSF2, BCL2, SP3, PSEN2, CASP8, MALT1, ITPKB, SCAND1, NHEJ1, IL2 751 131 13528 1.6500747095475752 1.0 0.9672690005819427 87.73379774724404 GOTERM_BP_FAT GO:0042110~T cell activation 10 0.8928571428571428 0.2645017576344656 EGR1, BCL2, SP3, SLA2, PSEN2, MALT1, ITPKB, HSPD1, NHEJ1, IL2 751 126 13528 1.4296282205736266 1.0 0.9830816457960394 99.58342980104705 GOTERM_BP_FAT GO:0030217~T cell differentiation 6 0.5357142857142857 0.2917923662337483 EGR1, BCL2, SP3, ITPKB, NHEJ1, IL2 751 65 13528 1.6627675919287106 1.0 0.9852505123169953 99.78781184350781 GOTERM_BP_FAT GO:0042113~B cell activation 6 0.5357142857142857 0.4140318586526262 EXO1, BCL2, SP3, MALT1, HSPD1, NHEJ1 751 76 13528 1.4221038615179762 1.0 0.9914526348355741 99.99277813923139 GOTERM_BP_FAT GO:0045321~leukocyte activation 15 1.3392857142857142 0.4846853837888777 EXO1, EGR1, CSF2, SLA2, TLR3, MALT1, ITPKB, ZNF3, SP3, BCL2, PSEN2, HSPD1, LBP, NHEJ1, IL2 751 242 13528 1.1165278251587416 1.0 0.9937327766663201 99.99927038133461 GOTERM_BP_FAT GO:0030183~B cell differentiation 4 0.35714285714285715 0.5017500387973651 BCL2, SP3, MALT1, NHEJ1 751 48 13528 1.501109631602308 1.0 0.9943294218838696 99.99959990001346 GOTERM_BP_FAT GO:0030098~lymphocyte differentiation 7 0.625 0.5105844595748477 EGR1, BCL2, SP3, MALT1, ITPKB, NHEJ1, IL2 751 103 13528 1.224205913151397 1.0 0.9947464602529621 99.99970922781192 GOTERM_BP_FAT GO:0001775~cell activation 17 1.5178571428571428 0.5401433296396455 EXO1, EGR1, CSF2, SLA2, COL3A1, TLR3, MALT1, ITPKB, ZNF3, GP1BB, SP3, BCL2, PSEN2, HSPD1, LBP, NHEJ1, IL2 751 287 13528 1.06699081828178 1.0 0.9951275188213214 99.99990431123899 GOTERM_BP_FAT GO:0046649~lymphocyte activation 11 0.9821428571428571 0.6709235847117374 EXO1, EGR1, BCL2, SP3, SLA2, PSEN2, MALT1, ITPKB, HSPD1, NHEJ1, IL2 751 199 13528 0.9957109114145963 1.0 0.9980244550911561 99.99999975559494 Annotation Cluster 105 Enrichment Score: 0.49745234849598474 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS cytoplasmic vesicle 19 1.6964285714285714 0.08637329092105922 CLCN3, CNST, SEC31A, ATG9A, TAOK2, AP1B1, ZDHHC8, SLA2, AP3S1, NOSTRIN, VGF, MARCH3, SLC32A1, AP1S1, MAP1LC3C, DOC2A, TRIM36, WIPF1, CLTCL1 1027 238 19235 1.4951969103123235 1.0 0.6896734433500233 73.30171136085137 GOTERM_CC_FAT GO:0031982~vesicle 42 3.75 0.29346797285246595 SRI, ALDOA, SEPT5, CALCR, CLCN3, SEC31A, VAPA, AP1B1, HPS4, AP3S1, NOSTRIN, VGF, SLC32A1, AP1S1, MAP1LC3C, GP1BB, LEFTY2, RAC1, SCG5, WIPF1, GAD1, MLANA, ATG9A, TAOK2, HTT, ZDHHC8, SLA2, PI4KA, F8, LRPAP1, MARCH3, VEGFC, DOC2A, TRIM36, ZG16, MYH11, ARSA, HSPD1, LRP2, STEAP2, SLC40A1, CLTCL1 713 670 12782 1.1237863976052416 1.0 0.9182668409181025 99.31134045959267 GOTERM_CC_FAT GO:0031988~membrane-bounded vesicle 34 3.0357142857142856 0.4285482469872658 ALDOA, SEPT5, CALCR, CLCN3, SEC31A, HPS4, AP3S1, NOSTRIN, VGF, SLC32A1, AP1S1, GP1BB, LEFTY2, RAC1, SCG5, WIPF1, GAD1, MLANA, TAOK2, HTT, SLA2, F8, PI4KA, VEGFC, DOC2A, TRIM36, ZG16, ARSA, MYH11, HSPD1, LRP2, STEAP2, SLC40A1, CLTCL1 713 568 12782 1.0730991841653004 1.0 0.9503647338076588 99.96708235075126 GOTERM_CC_FAT GO:0031410~cytoplasmic vesicle 37 3.303571428571429 0.5205972403904695 SEPT5, CALCR, CLCN3, SEC31A, AP1B1, HPS4, AP3S1, NOSTRIN, VGF, SLC32A1, AP1S1, MAP1LC3C, GP1BB, LEFTY2, RAC1, SCG5, WIPF1, MLANA, ATG9A, TAOK2, HTT, ZDHHC8, SLA2, PI4KA, F8, MARCH3, VEGFC, DOC2A, TRIM36, ZG16, MYH11, ARSA, HSPD1, LRP2, STEAP2, SLC40A1, CLTCL1 713 642 12782 1.033179973172895 1.0 0.9580220685374081 99.99734342290778 GOTERM_CC_FAT GO:0016023~cytoplasmic membrane-bounded vesicle 31 2.767857142857143 0.5758329255399541 SEPT5, CALCR, SEC31A, HPS4, AP3S1, NOSTRIN, VGF, SLC32A1, AP1S1, GP1BB, LEFTY2, RAC1, SCG5, WIPF1, MLANA, TAOK2, HTT, SLA2, F8, PI4KA, VEGFC, DOC2A, TRIM36, ZG16, ARSA, MYH11, HSPD1, LRP2, STEAP2, CLTCL1, SLC40A1 713 550 12782 1.0104347826086957 1.0 0.9626556426956002 99.99954030578351 Annotation Cluster 106 Enrichment Score: 0.48956391492505924 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045072~regulation of interferon-gamma biosynthetic process 3 0.26785714285714285 0.16001778417741222 TLR3, INHA, IL21 751 13 13528 4.156918979821776 1.0 0.9819303419800376 95.54440576186273 GOTERM_BP_FAT GO:0032649~regulation of interferon-gamma production 4 0.35714285714285715 0.23034338770126905 TLR3, INHA, HSPD1, IL21 751 30 13528 2.401775410563693 1.0 0.9819992455462694 99.06366928169487 GOTERM_BP_FAT GO:0042035~regulation of cytokine biosynthetic process 3 0.26785714285714285 0.9220707661916964 TLR3, INHA, IL21 751 74 13528 0.7302695505092309 1.0 0.9999762345299629 100.0 Annotation Cluster 107 Enrichment Score: 0.484287618715936 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0051287~NAD or NADH binding 5 0.4464285714285714 0.2659144179000187 CTBP1, NDUFV2, AOX1, PARP1, HPGD 725 47 12983 1.9050623624358034 1.0 0.9901566131915154 99.17312905797252 SP_PIR_KEYWORDS nad 13 1.1607142857142858 0.3089883520053572 NDUFB3, STEAP4, CTBP1, DHRS9, SCCPDH, ALDH7A1, AOX1, NDUFV2, HSD17B4, STEAP2, PARP1, STEAP1, HPGD 1027 189 19235 1.2882593262340096 1.0 0.8618596114092844 99.54974857159495 GOTERM_MF_FAT GO:0050662~coenzyme binding 12 1.0714285714285714 0.4289959086811715 FMO5, STEAP4, CTBP1, AIFM3, NDUFV2, AOX1, MIOX, TXNRD2, STEAP2, PARP1, STEAP1, HPGD 725 181 12983 1.1872432844351306 1.0 0.9962434951718091 99.98321419098751 Annotation Cluster 108 Enrichment Score: 0.48361919562258154 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0012501~programmed cell death 43 3.8392857142857144 0.08675332331412405 PHLPP1, FASTKD1, GULP1, STK17B, RNF216, PMAIP1, GREM1, CTNNBL1, TOP1, FIS1, TMEM173, PEG10, HAND2, BCL2, CASP8, RAC1, TGM2, SPATA4, HSPE1, EPO, CFLAR, ACTC1, AIFM3, TAOK2, HTT, TP53BP2, AIMP2, SCN2A, CIDEA, STAT1, NLRP3, ELMO1, PPM1F, CASP10, SEMA6A, CSRNP3, TNFAIP8, PSEN2, MFSD10, AVEN, JAK2, HSPD1, BLCAP 751 611 13528 1.26771288037118 1.0 0.9707031046910806 80.19139788401858 GOTERM_BP_FAT GO:0016265~death 49 4.375 0.1124326811970453 ALS2, FASTKD1, ZAK, RNF216, PMAIP1, CTNNBL1, TOP1, TMEM173, CASP8, CLUL1, AIFM3, SCN2A, NLRP3, ELMO1, PPM1F, TNFAIP8, PSEN2, MFSD10, AVEN, BLCAP, PHLPP1, MFSD8, GULP1, STK17B, GREM1, FIS1, PEG10, HAND2, BCL2, RAC1, TGM2, NEFH, SPATA4, HSPE1, EPO, CFLAR, ACTC1, TAOK2, TP53BP2, AIMP2, HTT, CIDEA, STAT1, AFG3L2, CASP10, SEMA6A, CSRNP3, JAK2, HSPD1 751 724 13528 1.2191332367156866 1.0 0.9676623607481161 88.09137968355475 GOTERM_BP_FAT GO:0006915~apoptosis 41 3.660714285714286 0.13517027457808944 PHLPP1, FASTKD1, GULP1, STK17B, RNF216, PMAIP1, GREM1, CTNNBL1, FIS1, TMEM173, PEG10, HAND2, BCL2, CASP8, RAC1, SPATA4, HSPE1, EPO, CFLAR, ACTC1, AIFM3, TAOK2, HTT, TP53BP2, AIMP2, SCN2A, CIDEA, STAT1, NLRP3, ELMO1, PPM1F, CASP10, SEMA6A, CSRNP3, TNFAIP8, PSEN2, MFSD10, AVEN, JAK2, HSPD1, BLCAP 751 602 13528 1.2268204962596936 1.0 0.9780732293702449 92.50483096688377 GOTERM_BP_FAT GO:0008219~cell death 48 4.285714285714286 0.13588499226546774 PHLPP1, ALS2, FASTKD1, MFSD8, ZAK, GULP1, STK17B, RNF216, PMAIP1, GREM1, CTNNBL1, FIS1, TOP1, TMEM173, PEG10, HAND2, BCL2, CASP8, RAC1, TGM2, CLUL1, NEFH, SPATA4, HSPE1, EPO, CFLAR, ACTC1, AIFM3, TAOK2, HTT, TP53BP2, AIMP2, SCN2A, CIDEA, STAT1, NLRP3, ELMO1, PPM1F, CASP10, SEMA6A, CSRNP3, TNFAIP8, PSEN2, MFSD10, AVEN, JAK2, HSPD1, BLCAP 751 719 13528 1.2025579246215987 1.0 0.9761287001472922 92.61457579544746 SP_PIR_KEYWORDS Apoptosis 26 2.3214285714285716 0.16546642796237304 PHLPP1, GULP1, STK17B, RNF216, PMAIP1, CTNNBL1, FIS1, PEG10, TMEM173, BCL2, CASP8, CFLAR, AIFM3, AIMP2, TP53BP2, HTT, CIDEA, NLRP3, ELMO1, PPM1F, CASP10, CSRNP3, TNFAIP8, AVEN, MFSD10, BLCAP 1027 381 19235 1.2781155520116947 1.0 0.7877567437647952 92.89447537787524 GOTERM_BP_FAT GO:0006916~anti-apoptosis 15 1.3392857142857142 0.2532555610678717 CSF2, IL3, CFLAR, HTT, MALT1, STRADB, ANXA5, NME5, BCL2, TNFAIP8, TGM2, SERPINB2, AVEN, IL2, HSPA9 751 206 13528 1.311649192662211 1.0 0.9826338399837354 99.45390711724744 GOTERM_BP_FAT GO:0043066~negative regulation of apoptosis 23 2.0535714285714284 0.326894547389541 CSF2, CFLAR, IL3, MAEA, HTT, CIDEA, MALT1, ASNS, PIM3, STRADB, ANXA5, NME5, DLX1, BCL2, PSEN2, TNFAIP8, SERPINB2, TGM2, AVEN, HSPD1, HSPA9, IL2, IHH 751 354 13528 1.1703566619272232 1.0 0.9878284764441158 99.91432829576185 GOTERM_BP_FAT GO:0043069~negative regulation of programmed cell death 23 2.0535714285714284 0.3514642487705753 CSF2, CFLAR, IL3, MAEA, HTT, CIDEA, MALT1, ASNS, PIM3, STRADB, ANXA5, NME5, DLX1, BCL2, PSEN2, TNFAIP8, SERPINB2, TGM2, AVEN, HSPD1, HSPA9, IL2, IHH 751 359 13528 1.1540564298669553 1.0 0.9890388861358483 99.95587137517238 GOTERM_BP_FAT GO:0060548~negative regulation of cell death 23 2.0535714285714284 0.35655930692754867 CSF2, CFLAR, IL3, MAEA, HTT, CIDEA, MALT1, ASNS, PIM3, STRADB, ANXA5, NME5, DLX1, BCL2, PSEN2, TNFAIP8, SERPINB2, TGM2, AVEN, HSPD1, HSPA9, IL2, IHH 751 360 13528 1.1508507175617695 1.0 0.9886363801149886 99.96166389452648 GOTERM_BP_FAT GO:0043065~positive regulation of apoptosis 25 2.232142857142857 0.5295289852441706 ZAK, STK17B, PMAIP1, SRC, CTNNBL1, BCL2, RAC1, CASP8, TGM2, CFLAR, AIFM3, TP53BP2, HTT, CIDEA, INHA, NLRP3, STAT1, MAPK1, CASP10, CAPN10, CSRNP3, PSEN2, JAK2, HSPD1, SCAND1 751 430 13528 1.0472857894899825 1.0 0.9951382535125253 99.99985622887634 GOTERM_BP_FAT GO:0043068~positive regulation of programmed cell death 25 2.232142857142857 0.5312497999182813 ZAK, STK17B, PMAIP1, SRC, CTNNBL1, BCL2, RAC1, CASP8, TGM2, CFLAR, AIFM3, TP53BP2, HTT, CIDEA, INHA, NLRP3, STAT1, MAPK1, CASP10, CAPN10, CSRNP3, PSEN2, JAK2, HSPD1, SCAND1 751 433 13528 1.0400297678537933 1.0 0.9951973555936604 99.99986532733519 GOTERM_BP_FAT GO:0010942~positive regulation of cell death 25 2.232142857142857 0.5406223723130027 ZAK, STK17B, PMAIP1, SRC, CTNNBL1, BCL2, RAC1, CASP8, TGM2, CFLAR, AIFM3, TP53BP2, HTT, CIDEA, INHA, NLRP3, STAT1, MAPK1, CASP10, CAPN10, CSRNP3, PSEN2, JAK2, HSPD1, SCAND1 751 435 13528 1.0352480217946953 1.0 0.9950979361911482 99.99990607413058 GOTERM_BP_FAT GO:0006917~induction of apoptosis 18 1.607142857142857 0.608159038877352 CFLAR, AIFM3, HTT, TP53BP2, STK17B, CIDEA, INHA, PMAIP1, NLRP3, STAT1, CASP10, MAPK1, PSEN2, RAC1, CASP8, TGM2, JAK2, SCAND1 751 320 13528 1.0132490013315578 1.0 0.9966534130592235 99.99999449587477 GOTERM_BP_FAT GO:0012502~induction of programmed cell death 18 1.607142857142857 0.6133564991382583 CFLAR, AIFM3, HTT, TP53BP2, STK17B, CIDEA, INHA, PMAIP1, NLRP3, STAT1, CASP10, MAPK1, PSEN2, RAC1, CASP8, TGM2, JAK2, SCAND1 751 321 13528 1.0100924623865997 1.0 0.9967547412431649 99.99999566263016 GOTERM_BP_FAT GO:0042981~regulation of apoptosis 43 3.8392857142857144 0.6817150813922332 CSF2, MAEA, ZAK, STK17B, ASNS, PMAIP1, SRC, CTNNBL1, BCL2, CASP8, RAC1, TGM2, HSPE1, HSPA9, IHH, CFLAR, IL3, AIFM3, HTT, TP53BP2, CIDEA, MALT1, PIM3, INHA, STRADB, ANXA5, STAT1, NLRP3, CASP10, MAPK1, NME5, DLX1, CAPN10, PSMG2, CSRNP3, TNFAIP8, PSEN2, SERPINB2, AVEN, JAK2, HSPD1, SCAND1, IL2 751 804 13528 0.9633987187895409 1.0 0.9982296789885754 99.99999986517804 GOTERM_BP_FAT GO:0043067~regulation of programmed cell death 43 3.8392857142857144 0.7060848979453509 CSF2, MAEA, ZAK, STK17B, ASNS, PMAIP1, SRC, CTNNBL1, BCL2, CASP8, RAC1, TGM2, HSPE1, HSPA9, IHH, CFLAR, IL3, AIFM3, HTT, TP53BP2, CIDEA, MALT1, PIM3, INHA, STRADB, ANXA5, STAT1, NLRP3, CASP10, MAPK1, NME5, DLX1, CAPN10, PSMG2, CSRNP3, TNFAIP8, PSEN2, SERPINB2, AVEN, JAK2, HSPD1, SCAND1, IL2 751 812 13528 0.9539071057965406 1.0 0.9985393890854106 99.99999996744876 GOTERM_BP_FAT GO:0010941~regulation of cell death 43 3.8392857142857144 0.714957643009754 CSF2, MAEA, ZAK, STK17B, ASNS, PMAIP1, SRC, CTNNBL1, BCL2, CASP8, RAC1, TGM2, HSPE1, HSPA9, IHH, CFLAR, IL3, AIFM3, HTT, TP53BP2, CIDEA, MALT1, PIM3, INHA, STRADB, ANXA5, STAT1, NLRP3, CASP10, MAPK1, NME5, DLX1, CAPN10, PSMG2, CSRNP3, TNFAIP8, PSEN2, SERPINB2, AVEN, JAK2, HSPD1, SCAND1, IL2 751 815 13528 0.950395791296676 1.0 0.9985744311007405 99.99999998116091 Annotation Cluster 109 Enrichment Score: 0.4828993355923521 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:CCHC-type 4 0.35714285714285715 0.14722351595573438 PEG10, ZCCHC2, RP9, CPSF4 1024 25 19113 2.98640625 1.0 0.999985219775851 94.0395919353403 INTERPRO IPR001878:Zinc finger, CCHC-type 4 0.35714285714285715 0.48417658789248896 PEG10, ZCCHC2, RP9, CPSF4 920 47 16659 1.5410730804810362 1.0 0.9999035748778938 99.9980044778855 SMART SM00343:ZnF_C2HC 4 0.35714285714285715 0.49925338998584756 PEG10, ZCCHC2, RP9, CPSF4 513 47 9079 1.5062004894031769 1.0 0.9938086335469825 99.9888824550147 Annotation Cluster 110 Enrichment Score: 0.47133787068068805 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0031572~G2/M transition DNA damage checkpoint 3 0.26785714285714285 0.16001778417741222 BRCC3, FAM175A, CCNA2 751 13 13528 4.156918979821776 1.0 0.9819303419800376 95.54440576186273 GOTERM_BP_FAT GO:0031576~G2/M transition checkpoint 3 0.26785714285714285 0.22143868232650876 BRCC3, FAM175A, CCNA2 751 16 13528 3.377496671105193 1.0 0.983274567091393 98.85036637838091 GOTERM_BP_FAT GO:0031570~DNA integrity checkpoint 5 0.4464285714285714 0.3256583395960351 CDC45, BRCC3, ZAK, FAM175A, CCNA2 751 52 13528 1.73204957492574 1.0 0.9880125791679204 99.91147732024697 GOTERM_BP_FAT GO:0000075~cell cycle checkpoint 7 0.625 0.3921257134076101 CDC45, MAD2L1, BRCC3, PSMG2, ZAK, FAM175A, CCNA2 751 91 13528 1.385639659940592 1.0 0.9900851217665704 99.98609951661201 GOTERM_BP_FAT GO:0000077~DNA damage checkpoint 4 0.35714285714285715 0.5017500387973651 BRCC3, ZAK, FAM175A, CCNA2 751 48 13528 1.501109631602308 1.0 0.9943294218838696 99.99959990001346 GOTERM_BP_FAT GO:0042770~DNA damage response, signal transduction 5 0.4464285714285714 0.6544494307647502 BRCC3, ZAK, FAM175A, CIDEA, CCNA2 751 80 13528 1.1258322237017309 1.0 0.9976455200380379 99.99999941574347 Annotation Cluster 111 Enrichment Score: 0.46340385663826433 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:FERM 5 0.4464285714285714 0.2545014061319628 EPB41L3, EPB41L1, NF2, KRIT1, JAK2 1024 48 19113 1.9442749023437502 1.0 0.999997408188109 99.44871870316202 INTERPRO IPR000299:FERM domain 5 0.4464285714285714 0.2596671742820674 EPB41L3, EPB41L1, NF2, KRIT1, JAK2 920 47 16659 1.926341350601295 1.0 0.9988931275754613 99.2664439744241 INTERPRO IPR000798:Ezrin/radixin/moesin ERM 3 0.26785714285714285 0.2614709191269608 EPB41L3, EPB41L1, NF2 920 18 16659 3.0179347826086955 1.0 0.9988234202762591 99.29512117244956 INTERPRO IPR019747:FERM conserved site 5 0.4464285714285714 0.29708352986847314 EPB41L3, EPB41L1, NF2, KRIT1, JAK2 920 50 16659 1.8107608695652175 1.0 0.9987789509890433 99.68578305508315 INTERPRO IPR019749:Band 4.1 domain 5 0.4464285714285714 0.29708352986847314 EPB41L3, EPB41L1, NF2, KRIT1, JAK2 920 50 16659 1.8107608695652175 1.0 0.9987789509890433 99.68578305508315 SMART SM00295:B41 5 0.4464285714285714 0.3110470571276692 EPB41L3, EPB41L1, NF2, KRIT1, JAK2 513 50 9079 1.769785575048733 1.0 0.9877984315385473 99.25859553704254 INTERPRO IPR018980:FERM, C-terminal PH-like domain 3 0.26785714285714285 0.40474118459356984 EPB41L3, EPB41L1, NF2 920 25 16659 2.172913043478261 1.0 0.9996990892889511 99.97925272589725 INTERPRO IPR019750:Band 4.1 subgroup 3 0.26785714285714285 0.40474118459356984 EPB41L3, EPB41L1, NF2 920 25 16659 2.172913043478261 1.0 0.9996990892889511 99.97925272589725 INTERPRO IPR014352:FERM/acyl-CoA-binding protein, 3-helical bundle 4 0.35714285714285715 0.42584603438416346 EPB41L3, EPB41L1, NF2, KRIT1 920 43 16659 1.684428715874621 1.0 0.999746140319082 99.98850071894272 INTERPRO IPR019748:FERM central domain 4 0.35714285714285715 0.48417658789248896 EPB41L3, EPB41L1, NF2, KRIT1 920 47 16659 1.5410730804810362 1.0 0.9999035748778938 99.9980044778855 INTERPRO IPR018979:FERM, N-terminal 3 0.26785714285714285 0.4986921224298277 EPB41L3, EPB41L1, NF2 920 30 16659 1.8107608695652173 1.0 0.9999208766522166 99.99874858292111 Annotation Cluster 112 Enrichment Score: 0.4625188723647577 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044439~peroxisomal part 5 0.4464285714285714 0.21630831327751449 FIS1, PEX1, HSD17B4, CROT, ACSL6 713 43 12782 2.0845428748491472 1.0 0.8824012398929396 96.95867539495516 GOTERM_CC_FAT GO:0044438~microbody part 5 0.4464285714285714 0.21630831327751449 FIS1, PEX1, HSD17B4, CROT, ACSL6 713 43 12782 2.0845428748491472 1.0 0.8824012398929396 96.95867539495516 SP_PIR_KEYWORDS peroxisome 7 0.625 0.3479820399719057 FIS1, PEX1, KIAA0430, HSD17B4, AGXT, CROT, ACSL6 1027 90 19235 1.4567240073569188 1.0 0.8830632232606026 99.8073886393797 GOTERM_CC_FAT GO:0042579~microbody 8 0.7142857142857143 0.3501298842222059 FIS1, PEX1, KIAA0430, ISOC1, HSD17B4, AGXT, CROT, ACSL6 713 103 12782 1.3923936872778768 1.0 0.9330250961929675 99.79215642680148 GOTERM_CC_FAT GO:0005777~peroxisome 8 0.7142857142857143 0.3501298842222059 FIS1, PEX1, KIAA0430, ISOC1, HSD17B4, AGXT, CROT, ACSL6 713 103 12782 1.3923936872778768 1.0 0.9330250961929675 99.79215642680148 GOTERM_BP_FAT GO:0007031~peroxisome organization 3 0.26785714285714285 0.36716575204022195 FIS1, PEX1, AGXT 751 23 13528 2.349562901638395 1.0 0.988861079767052 99.97150149109886 GOTERM_CC_FAT GO:0031903~microbody membrane 3 0.26785714285714285 0.5216901323733929 FIS1, PEX1, ACSL6 713 31 12782 1.7348776184228385 1.0 0.9572466634904839 99.9974289038217 GOTERM_CC_FAT GO:0005778~peroxisomal membrane 3 0.26785714285714285 0.5216901323733929 FIS1, PEX1, ACSL6 713 31 12782 1.7348776184228385 1.0 0.9572466634904839 99.9974289038217 Annotation Cluster 113 Enrichment Score: 0.4610740663464676 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051047~positive regulation of secretion 11 0.9821428571428571 0.08015421927889256 SEPT5, VEGFC, ACHE, CAPN10, GHRH, NNAT, TAC1, JAK2, INHA, NLRP3, IL2 751 109 13528 1.8178575355183912 1.0 0.9712811205147995 77.47622971587703 GOTERM_BP_FAT GO:0051046~regulation of secretion 17 1.5178571428571428 0.0957738012137629 SEPT5, CPLX4, ACHE, SNCAIP, NNAT, CIDEA, TAC1, INHA, NLRP3, VEGFC, DOC2A, CAPN10, GHRH, SCG5, RAPGEF4, JAK2, IL2 751 202 13528 1.515972103202331 1.0 0.9690638407827327 83.40637824099827 GOTERM_BP_FAT GO:0032880~regulation of protein localization 12 1.0714285714285714 0.14381891587195775 VEGFC, SUMO1, ACHE, CEP120, BCL2, NNAT, CIDEA, JAK2, TRIP6, NLRP3, TACC3, IL2 751 138 13528 1.56637526775893 1.0 0.9775230764188689 93.73521755234545 GOTERM_BP_FAT GO:0060341~regulation of cellular localization 18 1.607142857142857 0.21969777549163633 CPLX4, SEPT5, ACHE, SNCAIP, NNAT, CIDEA, INHA, NLRP3, TACC3, VEGFC, DOC2A, CAPN10, GHRH, SCG5, RAPGEF4, JAK2, TRIP6, IL2 751 248 13528 1.3074180662342683 1.0 0.9838783493605584 98.80362977831527 GOTERM_BP_FAT GO:0046883~regulation of hormone secretion 6 0.5357142857142857 0.30274741765076346 CAPN10, GHRH, NNAT, SCG5, JAK2, INHA 751 66 13528 1.6375741435661542 1.0 0.9860833559609836 99.83933199332252 GOTERM_BP_FAT GO:0051222~positive regulation of protein transport 6 0.5357142857142857 0.3137638697750964 VEGFC, ACHE, JAK2, TRIP6, NLRP3, IL2 751 67 13528 1.6131327384383014 1.0 0.9873447996981574 99.8790707170307 GOTERM_BP_FAT GO:0050714~positive regulation of protein secretion 4 0.35714285714285715 0.39893272355193987 VEGFC, ACHE, NLRP3, IL2 751 41 13528 1.7573966418758729 1.0 0.9904918093893557 99.98862961100954 GOTERM_BP_FAT GO:0050708~regulation of protein secretion 5 0.4464285714285714 0.40234939480136184 VEGFC, ACHE, CIDEA, NLRP3, IL2 751 58 13528 1.5528720326920427 1.0 0.9905470804522601 99.98972915722901 GOTERM_BP_FAT GO:0042306~regulation of protein import into nucleus 4 0.35714285714285715 0.4439484418354328 JAK2, TRIP6, NLRP3, TACC3 751 44 13528 1.6375741435661544 1.0 0.9926431770001295 99.9971646432946 GOTERM_BP_FAT GO:0051223~regulation of protein transport 8 0.7142857142857143 0.44660782062010324 VEGFC, ACHE, CIDEA, JAK2, TRIP6, NLRP3, TACC3, IL2 751 114 13528 1.264092321349312 1.0 0.9927185065449012 99.99739707278457 GOTERM_BP_FAT GO:0042990~regulation of transcription factor import into nucleus 3 0.26785714285714285 0.501427341333422 TRIP6, NLRP3, TACC3 751 30 13528 1.8013315579227698 1.0 0.994380912767868 99.99959525159535 GOTERM_BP_FAT GO:0070201~regulation of establishment of protein localization 8 0.7142857142857143 0.5095777197919591 VEGFC, ACHE, CIDEA, JAK2, TRIP6, NLRP3, TACC3, IL2 751 121 13528 1.1909630135026579 1.0 0.9948137601701122 99.99969836981832 GOTERM_BP_FAT GO:0032386~regulation of intracellular transport 5 0.4464285714285714 0.5597669663511518 CAPN10, JAK2, TRIP6, NLRP3, TACC3 751 71 13528 1.2685433506498378 1.0 0.9954627878297442 99.99995605033486 GOTERM_BP_FAT GO:0033157~regulation of intracellular protein transport 4 0.35714285714285715 0.5693919538771506 JAK2, TRIP6, NLRP3, TACC3 751 53 13528 1.359495515413411 1.0 0.9957036194155368 99.99997037395654 GOTERM_BP_FAT GO:0051050~positive regulation of transport 13 1.1607142857142858 0.5848082063909185 SEPT5, ACHE, NNAT, TAC1, INHA, NLRP3, VEGFC, CAPN10, GHRH, JAK2, NEDD4L, TRIP6, IL2 751 223 13528 1.0501035987890586 1.0 0.9960852765188306 99.99998454066017 GOTERM_BP_FAT GO:0046822~regulation of nucleocytoplasmic transport 4 0.35714285714285715 0.6310635540215259 JAK2, TRIP6, NLRP3, TACC3 751 58 13528 1.2422976261536343 1.0 0.9972533627706059 99.99999812068505 GOTERM_BP_FAT GO:0051224~negative regulation of protein transport 3 0.26785714285714285 0.6585022200966021 CIDEA, NLRP3, TACC3 751 40 13528 1.3509986684420772 1.0 0.9977706214315416 99.99999952664024 Annotation Cluster 114 Enrichment Score: 0.4572860222607647 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051349~positive regulation of lyase activity 7 0.625 0.10729331262443002 CALCR, FTMT, GNAL, GALR1, GHRH, CALCRL, ADCYAP1 751 59 13528 2.137173034823625 1.0 0.9704667711441964 86.79928666419838 GOTERM_BP_FAT GO:0019933~cAMP-mediated signaling 9 0.8035714285714285 0.15618647663149404 CALCR, GNAL, CHRM5, GALR1, GHRH, TGM2, MC4R, RAPGEF4, CALCRL 751 95 13528 1.7065246338215712 1.0 0.9824651002244059 95.16756153614993 GOTERM_BP_FAT GO:0007189~activation of adenylate cyclase activity by G-protein signaling pathway 5 0.4464285714285714 0.17933442787876092 CALCR, GNAL, GALR1, GHRH, CALCRL 751 40 13528 2.2516644474034617 1.0 0.9840046750609639 97.05799935870924 GOTERM_BP_FAT GO:0010579~positive regulation of adenylate cyclase activity by G-protein signaling pathway 5 0.4464285714285714 0.17933442787876092 CALCR, GNAL, GALR1, GHRH, CALCRL 751 40 13528 2.2516644474034617 1.0 0.9840046750609639 97.05799935870924 GOTERM_BP_FAT GO:0010578~regulation of adenylate cyclase activity involved in G-protein signaling 5 0.4464285714285714 0.17933442787876092 CALCR, GNAL, GALR1, GHRH, CALCRL 751 40 13528 2.2516644474034617 1.0 0.9840046750609639 97.05799935870924 GOTERM_BP_FAT GO:0019935~cyclic-nucleotide-mediated signaling 11 0.9821428571428571 0.18459768025469941 CALCR, GNAL, CHRM5, GALR1, GHRH, MC2R, TGM2, MC4R, MC5R, RAPGEF4, CALCRL 751 130 13528 1.5242036259346512 1.0 0.9836617096335714 97.37704847363655 GOTERM_BP_FAT GO:0007190~activation of adenylate cyclase activity 6 0.5357142857142857 0.1879785024925255 CALCR, GNAL, GALR1, GHRH, CALCRL, ADCYAP1 751 55 13528 1.965088972279385 1.0 0.9840389588007895 97.56444605122925 GOTERM_BP_FAT GO:0045762~positive regulation of adenylate cyclase activity 6 0.5357142857142857 0.1977277202689705 CALCR, GNAL, GALR1, GHRH, CALCRL, ADCYAP1 751 56 13528 1.9299980977743958 1.0 0.984512621625945 98.03660037117544 GOTERM_BP_FAT GO:0031281~positive regulation of cyclase activity 6 0.5357142857142857 0.20764627570898422 CALCR, GNAL, GALR1, GHRH, CALCRL, ADCYAP1 751 57 13528 1.8961384820239682 1.0 0.9833371679953984 98.42739502383805 GOTERM_BP_FAT GO:0019932~second-messenger-mediated signaling 17 1.5178571428571428 0.23223604240220028 CALCR, HMGB2, PI4KA, NDC80, BUD31, TYMS, GNAL, CHRM5, GALR1, BHLHA15, GHRH, MC2R, TGM2, MC4R, MC5R, RAPGEF4, CALCRL 751 235 13528 1.3030909142420037 1.0 0.9822739054976259 99.10390880446953 GOTERM_BP_FAT GO:0007187~G-protein signaling, coupled to cyclic nucleotide second messenger 9 0.8035714285714285 0.306068404259753 CALCR, GNAL, CHRM5, GALR1, GHRH, MC2R, MC4R, MC5R, CALCRL 751 115 13528 1.4097377409830372 1.0 0.9863552889712822 99.85245084767318 GOTERM_BP_FAT GO:0051339~regulation of lyase activity 8 0.7142857142857143 0.3275026705159328 CALCR, FTMT, GNAL, CHRM5, GALR1, GHRH, CALCRL, ADCYAP1 751 101 13528 1.4267972736021939 1.0 0.9877346464247443 99.91569874622998 GOTERM_BP_FAT GO:0007188~G-protein signaling, coupled to cAMP nucleotide second messenger 7 0.625 0.33203504475376444 CALCR, GNAL, CHRM5, GALR1, GHRH, MC4R, CALCRL 751 85 13528 1.4834495182893397 1.0 0.9882078698563701 99.92527994892527 GOTERM_BP_FAT GO:0045761~regulation of adenylate cyclase activity 7 0.625 0.4421467412196738 CALCR, GNAL, CHRM5, GALR1, GHRH, CALCRL, ADCYAP1 751 96 13528 1.3134709276520196 1.0 0.9926630981147089 99.99699618839799 GOTERM_BP_FAT GO:0031279~regulation of cyclase activity 7 0.625 0.4717905970961698 CALCR, GNAL, CHRM5, GALR1, GHRH, CALCRL, ADCYAP1 751 99 13528 1.273668778329231 1.0 0.9933169750258427 99.99886604746516 GOTERM_BP_FAT GO:0030817~regulation of cAMP biosynthetic process 7 0.625 0.4913083567877125 CALCR, GNAL, CHRM5, GALR1, GHRH, CALCRL, ADCYAP1 751 101 13528 1.2484476144019196 1.0 0.9939077894975101 99.99942074745047 GOTERM_BP_FAT GO:0030814~regulation of cAMP metabolic process 7 0.625 0.5105844595748477 CALCR, GNAL, CHRM5, GALR1, GHRH, CALCRL, ADCYAP1 751 103 13528 1.224205913151397 1.0 0.9947464602529621 99.99970922781192 GOTERM_BP_FAT GO:0030808~regulation of nucleotide biosynthetic process 7 0.625 0.5756591074277878 CALCR, GNAL, CHRM5, GALR1, GHRH, CALCRL, ADCYAP1 751 110 13528 1.146301900496308 1.0 0.9958333384340993 99.99997719260386 GOTERM_BP_FAT GO:0030802~regulation of cyclic nucleotide biosynthetic process 7 0.625 0.5756591074277878 CALCR, GNAL, CHRM5, GALR1, GHRH, CALCRL, ADCYAP1 751 110 13528 1.146301900496308 1.0 0.9958333384340993 99.99997719260386 GOTERM_BP_FAT GO:0030799~regulation of cyclic nucleotide metabolic process 7 0.625 0.6021960364899173 CALCR, GNAL, CHRM5, GALR1, GHRH, CALCRL, ADCYAP1 751 113 13528 1.115869106677822 1.0 0.9965097387598048 99.99999279370498 GOTERM_BP_FAT GO:0006140~regulation of nucleotide metabolic process 7 0.625 0.6278105467006154 CALCR, GNAL, CHRM5, GALR1, GHRH, CALCRL, ADCYAP1 751 116 13528 1.08701042288443 1.0 0.9971430540907266 99.99999780204763 GOTERM_BP_FAT GO:0051350~negative regulation of lyase activity 3 0.26785714285714285 0.8170358884003388 GNAL, CHRM5, GALR1 751 55 13528 0.9825444861396925 1.0 0.9996133115346861 99.99999999999308 GOTERM_BP_FAT GO:0007194~negative regulation of adenylate cyclase activity 3 0.26785714285714285 0.8170358884003388 GNAL, CHRM5, GALR1 751 55 13528 0.9825444861396925 1.0 0.9996133115346861 99.99999999999308 GOTERM_BP_FAT GO:0031280~negative regulation of cyclase activity 3 0.26785714285714285 0.8170358884003388 GNAL, CHRM5, GALR1 751 55 13528 0.9825444861396925 1.0 0.9996133115346861 99.99999999999308 KEGG_PATHWAY hsa04080:Neuroactive ligand-receptor interaction 10 0.8928571428571428 0.9714293323576338 CALCR, CHRM5, GPR35, P2RX6, GALR1, GLRA3, MC2R, MC4R, MC5R, CALCRL 301 256 5085 0.6599096760797343 1.0 0.9981622191028392 100.0 Annotation Cluster 115 Enrichment Score: 0.4566707248574017 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0031663~lipopolysaccharide-mediated signaling pathway 3 0.26785714285714285 0.12120616114417043 MAPK1, LBP, STAT1 751 11 13528 4.912722430698462 1.0 0.9707918536778892 90.02552137246539 GOTERM_BP_FAT GO:0002237~response to molecule of bacterial origin 7 0.625 0.3419995841505713 MAPK1, TAC1, MALT1, LBP, COMT, STAT1, VLDLR 751 86 13528 1.4662001052859752 1.0 0.9886751194784756 99.94285475332649 GOTERM_BP_FAT GO:0032496~response to lipopolysaccharide 6 0.5357142857142857 0.42512718856009823 MAPK1, TAC1, LBP, COMT, STAT1, VLDLR 751 77 13528 1.4036349801995607 1.0 0.9920834578741531 99.99486513233684 GOTERM_BP_FAT GO:0009617~response to bacterium 9 0.8035714285714285 0.8457615657669276 MAPK1, BPI, TLR3, TAC1, MALT1, LBP, COMT, STAT1, VLDLR 751 193 13528 0.8399991720883382 1.0 0.9997831023364556 99.99999999999967 Annotation Cluster 116 Enrichment Score: 0.45521834830524227 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE metal ion-binding site:Iron-sulfur (2Fe-2S) 3 0.26785714285714285 0.0968248271657613 AIFM3, NDUFV2, AOX1 1024 10 19113 5.5995117187500005 1.0 0.999973171711018 83.5244537048333 SP_PIR_KEYWORDS 2Fe-2S 3 0.26785714285714285 0.18909827874847995 AIFM3, NDUFV2, AOX1 1027 15 19235 3.745861733203505 1.0 0.811354200206355 95.33107459900154 GOTERM_MF_FAT GO:0051537~2 iron, 2 sulfur cluster binding 3 0.26785714285714285 0.24443432549795174 AIFM3, NDUFV2, AOX1 725 17 12983 3.160162271805274 1.0 0.9906583551143602 98.70659060876002 SP_PIR_KEYWORDS iron-sulfur 3 0.26785714285714285 0.6884415956594591 AIFM3, NDUFV2, AOX1 1027 44 19235 1.2769983181375586 1.0 0.9712605758636108 99.99999605441043 GOTERM_MF_FAT GO:0051540~metal cluster binding 3 0.26785714285714285 0.7762348806929231 AIFM3, NDUFV2, AOX1 725 50 12983 1.0744551724137932 1.0 0.9997433371177654 99.99999999179916 GOTERM_MF_FAT GO:0051536~iron-sulfur cluster binding 3 0.26785714285714285 0.7762348806929231 AIFM3, NDUFV2, AOX1 725 50 12983 1.0744551724137932 1.0 0.9997433371177654 99.99999999179916 Annotation Cluster 117 Enrichment Score: 0.44827794671307786 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051318~G1 phase 4 0.35714285714285715 0.10752237515496998 CDC23, CDK6, ZNF655, CDC25C 751 21 13528 3.4311077293767043 1.0 0.9683373151076069 86.8595874289429 GOTERM_BP_FAT GO:0000080~G1 phase of mitotic cell cycle 3 0.26785714285714285 0.26334319804522643 CDC23, CDK6, CDC25C 751 18 13528 3.002219263204616 1.0 0.9833917920438355 99.57156628706772 GOTERM_BP_FAT GO:0051325~interphase 8 0.7142857142857143 0.37316724702744775 DBF4, BCL2, CDC23, CDK6, ZNF655, CDC25C, DNAJC2, NFATC1 751 106 13528 1.359495515413411 1.0 0.9886596026069628 99.97595687005519 KEGG_PATHWAY hsa04110:Cell cycle 9 0.8035714285714285 0.4591838451169802 CDC45, MCM7, MAD2L1, DBF4, RBL1, CDC23, CDK6, CDC25C, CCNA2 301 125 5085 1.216345514950166 1.0 0.902709160221848 99.94160431850403 GOTERM_BP_FAT GO:0051329~interphase of mitotic cell cycle 7 0.625 0.5105844595748477 DBF4, BCL2, CDC23, CDK6, CDC25C, DNAJC2, NFATC1 751 103 13528 1.224205913151397 1.0 0.9947464602529621 99.99970922781192 GOTERM_BP_FAT GO:0000082~G1/S transition of mitotic cell cycle 3 0.26785714285714285 0.8248094987335071 DBF4, BCL2, NFATC1 751 56 13528 0.9649990488871979 1.0 0.999661782349352 99.99999999999682 Annotation Cluster 118 Enrichment Score: 0.4406578018543417 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:HEAT 3 5 0.4464285714285714 0.27850637328744976 SF3B1, HTT, PPP4R1, RANBP6, KIAA1468 1024 50 19113 1.86650390625 1.0 0.9999950919404639 99.69120137111878 UP_SEQ_FEATURE repeat:HEAT 5 4 0.35714285714285715 0.2880149371989862 SF3B1, HTT, PPP4R1, RANBP6 1024 35 19113 2.1331473214285714 1.0 0.999996418474883 99.75585238544785 INTERPRO IPR000357:HEAT 5 0.4464285714285714 0.3605586271899945 SF3B1, HTT, PPP4R1, RANBP6, KIAA1468 920 55 16659 1.6461462450592885 1.0 0.9994079491523975 99.9331208496495 UP_SEQ_FEATURE repeat:HEAT 7 3 0.26785714285714285 0.37050073171490644 SF3B1, PPP4R1, RANBP6 1024 24 19113 2.3331298828125 1.0 0.9999980395848098 99.97241066800787 UP_SEQ_FEATURE repeat:HEAT 1 5 0.4464285714285714 0.37675354827869456 SF3B1, HTT, PPP4R1, RANBP6, KIAA1468 1024 58 19113 1.6090550915948276 1.0 0.999997733637514 99.97688081396888 UP_SEQ_FEATURE repeat:HEAT 2 5 0.4464285714285714 0.37675354827869456 SF3B1, HTT, PPP4R1, RANBP6, KIAA1468 1024 58 19113 1.6090550915948276 1.0 0.999997733637514 99.97688081396888 UP_SEQ_FEATURE repeat:HEAT 4 4 0.35714285714285715 0.40661002006804864 SF3B1, HTT, PPP4R1, RANBP6 1024 43 19113 1.7362827034883723 1.0 0.9999979407930867 99.99030697952365 UP_SEQ_FEATURE repeat:HEAT 6 3 0.26785714285714285 0.48242487676486906 SF3B1, PPP4R1, RANBP6 1024 30 19113 1.86650390625 1.0 0.9999994548674384 99.99913854804863 Annotation Cluster 119 Enrichment Score: 0.4368004322428765 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005741~mitochondrial outer membrane 8 0.7142857142857143 0.23496750127842708 CPT1B, FIS1, TMEM173, CHKB, BCL2, CASP8, CYB5A, ABCB6, ACSL6 713 90 12782 1.5935172198846812 1.0 0.8883773639615754 97.84676998518536 SP_PIR_KEYWORDS mitochondrion outer membrane 6 0.5357142857142857 0.3177187912913022 CPT1B, FIS1, TMEM173, CHKB, BCL2, ABCB6, ACSL6 1027 70 19235 1.6053693142300736 1.0 0.865870374526206 99.6261217227391 GOTERM_CC_FAT GO:0031968~organelle outer membrane 8 0.7142857142857143 0.35932642809494597 CPT1B, FIS1, TMEM173, CHKB, BCL2, CASP8, CYB5A, ABCB6, ACSL6 713 104 12782 1.3790052864386664 1.0 0.9342656853793735 99.8305525133983 GOTERM_CC_FAT GO:0019867~outer membrane 8 0.7142857142857143 0.39626259926786167 CPT1B, FIS1, TMEM173, CHKB, BCL2, CASP8, CYB5A, ABCB6, ACSL6 713 108 12782 1.3279310165705678 1.0 0.94122648534649 99.92764421417203 GOTERM_CC_FAT GO:0031966~mitochondrial membrane 22 1.9642857142857142 0.6158499271455236 NDUFB3, CPT1B, ATP5J2, AIFM3, CHKB, CYB5A, AFG3L2, ABCB6, ATP5G3, SLC25A12, FIS1, TMEM173, SLC25A31, BCL2, NIPSNAP1, NDUFV2, CASP8, SLC25A1, HSPD1, SCO2, SLC25A40, PMPCB, ACSL6 713 394 12782 1.0010038373641081 1.0 0.9657123058621184 99.9998888915686 Annotation Cluster 120 Enrichment Score: 0.4261627401205074 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051604~protein maturation 10 0.8928571428571428 0.23540233635017657 F11, SEC11C, DISP1, KLKB1, PSEN2, SPCS3, SCG5, HSPD1, PARP1, IHH 751 122 13528 1.4765012769858765 1.0 0.9825953270091532 99.1675999901807 GOTERM_BP_FAT GO:0016485~protein processing 8 0.7142857142857143 0.4283144184408971 F11, SEC11C, KLKB1, PSEN2, SPCS3, SCG5, PARP1, IHH 751 112 13528 1.286665398516264 1.0 0.9919838945890868 99.99535001324111 GOTERM_BP_FAT GO:0051605~protein maturation by peptide bond cleavage 6 0.5357142857142857 0.5223219974035433 F11, SEC11C, KLKB1, PSEN2, SPCS3, SCG5 751 86 13528 1.2567429473879788 1.0 0.9950099155756702 99.99981143360647 Annotation Cluster 121 Enrichment Score: 0.4229005746496451 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042326~negative regulation of phosphorylation 5 0.4464285714285714 0.2379256132539181 NF2, PSEN2, PRKRIP1, INHA, IL2 751 45 13528 2.0014795088030772 1.0 0.9819243145682289 99.21527124200841 GOTERM_BP_FAT GO:0010563~negative regulation of phosphorus metabolic process 5 0.4464285714285714 0.2749851928598685 NF2, PSEN2, PRKRIP1, INHA, IL2 751 48 13528 1.876387039502885 1.0 0.9839326400454799 99.67755619672344 GOTERM_BP_FAT GO:0045936~negative regulation of phosphate metabolic process 5 0.4464285714285714 0.2749851928598685 NF2, PSEN2, PRKRIP1, INHA, IL2 751 48 13528 1.876387039502885 1.0 0.9839326400454799 99.67755619672344 GOTERM_BP_FAT GO:0001933~negative regulation of protein amino acid phosphorylation 3 0.26785714285714285 0.5363235366090169 NF2, PSEN2, IL2 751 32 13528 1.6887483355525965 1.0 0.9952379010264989 99.99988909383956 GOTERM_BP_FAT GO:0031400~negative regulation of protein modification process 6 0.5357142857142857 0.7961785169486193 MAD2L1, NF2, PSMC2, PSEN2, CDC23, IL2 751 119 13528 0.9082343989526569 1.0 0.9994660172324321 99.99999999995254 Annotation Cluster 122 Enrichment Score: 0.4217050227908808 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045638~negative regulation of myeloid cell differentiation 4 0.35714285714285715 0.23034338770126905 MAFB, TLR3, INHA, THOC5 751 30 13528 2.401775410563693 1.0 0.9819992455462694 99.06366928169487 GOTERM_BP_FAT GO:0002762~negative regulation of myeloid leukocyte differentiation 3 0.26785714285714285 0.24235248431389422 TLR3, INHA, THOC5 751 17 13528 3.1788203963342996 1.0 0.981927950213941 99.29274007460285 GOTERM_BP_FAT GO:0045637~regulation of myeloid cell differentiation 5 0.4464285714285714 0.5484132912121372 MAFB, TLR3, CDK6, INHA, THOC5 751 70 13528 1.2866653985162642 1.0 0.9952159761923591 99.99993077702453 GOTERM_BP_FAT GO:0002761~regulation of myeloid leukocyte differentiation 3 0.26785714285714285 0.6718134763314597 TLR3, INHA, THOC5 751 41 13528 1.3180474814069045 1.0 0.9980294565286589 99.99999976712174 Annotation Cluster 123 Enrichment Score: 0.41377117814966047 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006071~glycerol metabolic process 3 0.26785714285714285 0.36716575204022195 MOGAT3, COQ2, GDPD3 751 23 13528 2.349562901638395 1.0 0.988861079767052 99.97150149109886 GOTERM_BP_FAT GO:0019751~polyol metabolic process 4 0.35714285714285715 0.38369269345455764 MOGAT3, COQ2, MIOX, GDPD3 751 40 13528 1.8013315579227698 1.0 0.9895648442492804 99.98222612701208 GOTERM_BP_FAT GO:0019400~alditol metabolic process 3 0.26785714285714285 0.4072309444222758 MOGAT3, COQ2, GDPD3 751 25 13528 2.161597869507324 1.0 0.990948730362974 99.99112722561188 Annotation Cluster 124 Enrichment Score: 0.41019364112392115 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0015813~L-glutamate transport 3 0.26785714285714285 0.1801758674334446 SLC25A12, HTT, SLC1A1 751 14 13528 3.8599961955487916 1.0 0.9828292448503038 97.11135401187137 GOTERM_BP_FAT GO:0046942~carboxylic acid transport 12 1.0714285714285714 0.1926563765318717 CPT1B, HTT, CHKB, SLC38A11, AGXT, SLC32A1, SLC25A12, SLC23A1, ATP8B1, SLC25A1, FABP2, SLC1A1, CROT 751 147 13528 1.4704747411614445 1.0 0.9839726168261791 97.80298579263864 GOTERM_BP_FAT GO:0015849~organic acid transport 12 1.0714285714285714 0.19850099486484912 CPT1B, HTT, CHKB, SLC38A11, AGXT, SLC32A1, SLC25A12, SLC23A1, ATP8B1, SLC25A1, FABP2, SLC1A1, CROT 751 148 13528 1.4605391010184618 1.0 0.984353322863911 98.0700905726671 GOTERM_BP_FAT GO:0015800~acidic amino acid transport 3 0.26785714285714285 0.22143868232650876 SLC25A12, HTT, SLC1A1 751 16 13528 3.377496671105193 1.0 0.983274567091393 98.85036637838091 GOTERM_BP_FAT GO:0006839~mitochondrial transport 6 0.5357142857142857 0.33593970846831084 SLC25A12, CPT1B, BHLHA15, HTT, CHKB, BCL2, SLC25A1 751 69 13528 1.56637526775893 1.0 0.9885438126228219 99.93270061284521 GOTERM_BP_FAT GO:0015711~organic anion transport 4 0.35714285714285715 0.4439484418354328 SLC25A12, HTT, SLC25A1, SLC1A1 751 44 13528 1.6375741435661544 1.0 0.9926431770001295 99.9971646432946 GOTERM_BP_FAT GO:0015837~amine transport 8 0.7142857142857143 0.4828415080925045 SLC25A12, SLC32A1, CPT1B, CHRM5, HTT, CHKB, SERPINB7, SLC38A11, SLC1A1 751 118 13528 1.2212417341849287 1.0 0.9937376561839713 99.99922237390454 GOTERM_BP_FAT GO:0006865~amino acid transport 6 0.5357142857142857 0.5632301128280983 SLC25A12, SLC32A1, CPT1B, HTT, CHKB, SLC38A11, SLC1A1 751 90 13528 1.2008877052818465 1.0 0.9954652670995958 99.99996182648397 GOTERM_MF_FAT GO:0015179~L-amino acid transmembrane transporter activity 3 0.26785714285714285 0.6338424750102879 SLC25A12, SLC32A1, SLC1A1 725 38 12983 1.4137568058076226 1.0 0.999337769085272 99.99998295738519 GOTERM_MF_FAT GO:0015171~amino acid transmembrane transporter activity 3 0.26785714285714285 0.8487692962153919 SLC25A12, SLC32A1, SLC1A1 725 59 12983 0.9105552308591467 1.0 0.9999182770557582 99.9999999999812 GOTERM_MF_FAT GO:0005275~amine transmembrane transporter activity 3 0.26785714285714285 0.9236733672125954 SLC25A12, SLC32A1, SLC1A1 725 74 12983 0.7259832246039143 1.0 0.9999909929146089 100.0 Annotation Cluster 125 Enrichment Score: 0.41016218670049537 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006919~activation of caspase activity 6 0.5357142857142857 0.17840917535562695 AIFM3, HSPE1, PMAIP1, HSPD1, NLRP3, STAT1 751 54 13528 2.0014795088030777 1.0 0.9846269749974524 96.9982569041437 GOTERM_BP_FAT GO:0010952~positive regulation of peptidase activity 6 0.5357142857142857 0.22794848107442703 AIFM3, HSPE1, PMAIP1, HSPD1, NLRP3, STAT1 751 59 13528 1.831862601277393 1.0 0.9819439077522709 99.01030433479592 GOTERM_BP_FAT GO:0043280~positive regulation of caspase activity 6 0.5357142857142857 0.22794848107442703 AIFM3, HSPE1, PMAIP1, HSPD1, NLRP3, STAT1 751 59 13528 1.831862601277393 1.0 0.9819439077522709 99.01030433479592 GOTERM_BP_FAT GO:0043281~regulation of caspase activity 6 0.5357142857142857 0.4471895002190333 AIFM3, HSPE1, PMAIP1, HSPD1, NLRP3, STAT1 751 79 13528 1.3680999174096986 1.0 0.9925656227803545 99.99744545564249 GOTERM_BP_FAT GO:0052548~regulation of endopeptidase activity 6 0.5357142857142857 0.4798521033440926 AIFM3, HSPE1, PMAIP1, HSPD1, NLRP3, STAT1 751 82 13528 1.3180474814069045 1.0 0.9936355616307284 99.99913815319448 GOTERM_BP_FAT GO:0052547~regulation of peptidase activity 6 0.5357142857142857 0.5223219974035433 AIFM3, HSPE1, PMAIP1, HSPD1, NLRP3, STAT1 751 86 13528 1.2567429473879788 1.0 0.9950099155756702 99.99981143360647 GOTERM_BP_FAT GO:0051345~positive regulation of hydrolase activity 11 0.9821428571428571 0.5365917212863055 ALS2, AIFM3, RALBP1, TGM2, HSPE1, JAK2, PMAIP1, HSPD1, NLRP3, STAT1, BUD31 751 179 13528 1.1069635272151097 1.0 0.995192830849068 99.99989023272225 GOTERM_BP_FAT GO:0051336~regulation of hydrolase activity 14 1.25 0.9384921194269981 ALS2, AIFM3, RALBP1, AGFG2, PMAIP1, NLRP3, STAT1, BUD31, RAPGEF6, ALS2CR12, TGM2, JAK2, HSPE1, HSPD1 751 337 13528 0.7483276501756314 1.0 0.9999889214200143 100.0 Annotation Cluster 126 Enrichment Score: 0.40734909334547686 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0033554~cellular response to stress 37 3.303571428571429 0.2201279397345523 KIF22, HMGB2, ZAK, ATG12, FAM175A, NEK1, BMPR2, ROMO1, ZNF12, CETN1, ASNS, TYMS, SUMO1, CHD1L, MCM7, XYLT1, BCL2, POLN, PMS2, TLK1, PMS2CL, CCNA2, PMS1, POLL, EXO1, ATG9A, BRCC3, CIDEA, STRADB, EEPD1, MAPK1, CRKL, MAPK12, MAPK8IP2, JAK2, PARP1, NHEJ1 751 566 13528 1.1775488982887363 1.0 0.9836249444372711 98.81534203242961 GOTERM_BP_FAT GO:0006974~response to DNA damage stimulus 25 2.232142857142857 0.26130513928481136 KIF22, HMGB2, ZAK, FAM175A, NEK1, ZNF12, TYMS, SUMO1, CHD1L, MCM7, PMS2, POLN, TLK1, PMS2CL, CCNA2, PMS1, EXO1, POLL, BRCC3, CIDEA, EEPD1, MAPK1, MAPK12, PARP1, NHEJ1 751 373 13528 1.2073267814495776 1.0 0.9837689166423631 99.54991913691975 GOTERM_BP_FAT GO:0006259~DNA metabolic process 32 2.857142857142857 0.318676919515663 KIF22, HMGB2, ACHE, FAM175A, DNAH14, LIN9, DBF4, ZNF12, TYMS, TOP1, SUMO1, CDC45, TYMP, CHD1L, MCM7, PMS2, POLN, PMS2CL, DNAJC2, PMS1, POLL, EXO1, MCM3AP, BRCC3, CIDEA, CDC25C, EEPD1, HSPD1, KCTD13, PARP1, NHEJ1, TOP3B 751 506 13528 1.1391820129155856 1.0 0.9872400541648676 99.89362020685813 GOTERM_BP_FAT GO:0006281~DNA repair 17 1.5178571428571428 0.5220121050613988 POLL, EXO1, KIF22, HMGB2, BRCC3, FAM175A, ZNF12, EEPD1, TYMS, SUMO1, CHD1L, PMS2, POLN, PMS2CL, PARP1, NHEJ1, PMS1 751 284 13528 1.078261848052362 1.0 0.9950553079162695 99.99980923912337 SP_PIR_KEYWORDS dna repair 11 0.9821428571428571 0.5700811151366599 POLL, EXO1, BRCC3, CHD1L, FAM175A, PMS2, POLN, ZNF12, PARP1, NHEJ1, PMS1 1027 191 19235 1.0786512844303286 1.0 0.952793489003489 99.9995629613612 SP_PIR_KEYWORDS DNA damage 11 0.9821428571428571 0.65934767729881 POLL, EXO1, BRCC3, CHD1L, FAM175A, PMS2, POLN, TLK1, PARP1, NHEJ1, PMS1 1027 205 19235 1.0049872942741112 1.0 0.9668966664670778 99.99998544830434 Annotation Cluster 127 Enrichment Score: 0.4058620417417485 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR002048:Calcium-binding EF-hand 12 1.0714285714285714 0.1664592775792863 SLC25A12, SRI, FKBP9, OCM, CAPN8, EFCAB2, CETN1, MYL12B, MYL12A, CAPN2, OCM2, MYL9 920 143 16659 1.5195196108239586 1.0 0.9981472636862502 94.9027460671142 SMART SM00054:EFh 12 1.0714285714285714 0.1831869589643805 SLC25A12, SRI, FKBP9, OCM, CAPN8, EFCAB2, CETN1, MYL12B, MYL12A, CAPN2, OCM2, MYL9 513 143 9079 1.485134748292643 1.0 0.9855010778631574 93.02968892644877 SP_PIR_KEYWORDS EF hand 6 0.5357142857142857 0.21521375437440582 SRI, OCM, CETN1, MYL12A, CAPN2, OCM2 1027 60 19235 1.8729308666017526 1.0 0.822819090590122 97.10677240486844 INTERPRO IPR011992:EF-Hand type 17 1.5178571428571428 0.23169810530485502 SRI, FKBP9, OCM, CAPN8, SPOCK1, MYL12B, CETN1, MYL12A, OCM2, CAPN2, STAT1, MYL9, SLC25A12, PLCL1, STAT4, RYR3, EFCAB2 920 236 16659 1.304361643330877 1.0 0.9985404636703322 98.6550344612242 SP_PIR_KEYWORDS calcium binding 8 0.7142857142857143 0.3105367388802601 SRI, LAMA1, DOC2A, OCM, MYL12A, CAPN2, ANXA5, OCM2 1027 103 19235 1.4547035857100994 1.0 0.8608958809278768 99.56427466392768 PIR_SUPERFAMILY PIRSF002350:calmodulin 3 0.26785714285714285 0.3683631418798653 CETN1, MYL12A, MYL9 395 24 7396 2.340506329113924 1.0 0.9999994815282055 99.82628872845132 UP_SEQ_FEATURE domain:EF-hand 3 7 0.625 0.389618551020384 SLC25A12, SRI, CETN1, MYL12B, MYL12A, CAPN2, MYL9 1024 94 19113 1.3899497174202127 1.0 0.9999980564480914 99.98402021825167 INTERPRO IPR018247:EF-HAND 1 14 1.25 0.4205118493339337 SRI, FKBP9, OCM, CAPN8, MSTN, CETN1, MYL12B, MYL12A, OCM2, CAPN2, MYL9, SLC25A12, PLCG1, HSPA9 920 217 16659 1.1682328190743339 1.0 0.9997588448195612 99.98662400389833 COG_ONTOLOGY Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only 4 0.35714285714285715 0.4292655579515353 MYL12B, MYL12A, CAPN2, MYL9 109 43 1950 1.6641775122679754 0.9999995351785906 0.945867607185475 98.99406516164612 UP_SEQ_FEATURE domain:EF-hand 2 11 0.9821428571428571 0.5123656848202836 SLC25A12, SRI, FKBP9, OCM, EFCAB2, CETN1, MYL12B, MYL12A, CAPN2, OCM2, MYL9 1024 182 19113 1.1281067565247254 1.0 0.9999997816581848 99.9997000971778 UP_SEQ_FEATURE domain:EF-hand 1 11 0.9821428571428571 0.5123656848202836 SLC25A12, SRI, FKBP9, OCM, EFCAB2, CETN1, MYL12B, MYL12A, CAPN2, OCM2, MYL9 1024 182 19113 1.1281067565247254 1.0 0.9999997816581848 99.9997000971778 INTERPRO IPR018249:EF-HAND 2 13 1.1607142857142858 0.525819671544572 SRI, FKBP9, OCM, CETN1, MYL12B, MYL12A, OCM2, CAPN2, MYL9, SLC25A12, PLCG1, RYR3, EFCAB2 920 215 16659 1.0948786653185036 1.0 0.9999496313637667 99.99949600569855 INTERPRO IPR018248:EF hand 8 0.7142857142857143 0.5810137570907913 SRI, OCM, RYR3, CETN1, MYL12B, MYL12A, OCM2, MYL9 920 130 16659 1.1143143812709029 1.0 0.999971876661406 99.99993334400928 UP_SEQ_FEATURE calcium-binding region:2 7 0.625 0.5844377995428996 SLC25A12, SRI, FKBP9, OCM, CETN1, CAPN2, OCM2 1024 115 19113 1.1361328124999999 1.0 0.9999999432344686 99.9999823371599 UP_SEQ_FEATURE calcium-binding region:1 7 0.625 0.6727770833492337 SLC25A12, SRI, FKBP9, OCM, CETN1, CAPN2, OCM2 1024 126 19113 1.0369466145833333 1.0 0.9999999907992871 99.99999974344821 UP_SEQ_FEATURE domain:EF-hand 4 3 0.26785714285714285 0.831546229327898 SLC25A12, SRI, CETN1 1024 59 19113 0.949069782838983 1.0 0.9999999999559791 99.999999999998 Annotation Cluster 128 Enrichment Score: 0.39800025466531563 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006200~ATP catabolic process 3 0.26785714285714285 0.22143868232650876 VPS4B, OLA1, ABCC6 751 16 13528 3.377496671105193 1.0 0.983274567091393 98.85036637838091 GOTERM_BP_FAT GO:0046034~ATP metabolic process 9 0.8035714285714285 0.22657314751280977 ALDOA, ATP5J2, ATP9B, ATP8B1, AK3, VPS4B, OLA1, ATP5G3, ABCC6 751 105 13528 1.5439984782195166 1.0 0.9818517012031401 98.97837362318278 GOTERM_BP_FAT GO:0006195~purine nucleotide catabolic process 4 0.35714285714285715 0.27582046409861966 PDE5A, VPS4B, OLA1, ABCC6 751 33 13528 2.183432191421539 1.0 0.9838620344096096 99.68411984099707 GOTERM_BP_FAT GO:0009203~ribonucleoside triphosphate catabolic process 3 0.26785714285714285 0.28433811594414127 VPS4B, OLA1, ABCC6 751 19 13528 2.8442077230359524 1.0 0.9850057907059313 99.74423032459922 GOTERM_BP_FAT GO:0009207~purine ribonucleoside triphosphate catabolic process 3 0.26785714285714285 0.28433811594414127 VPS4B, OLA1, ABCC6 751 19 13528 2.8442077230359524 1.0 0.9850057907059313 99.74423032459922 GOTERM_BP_FAT GO:0009146~purine nucleoside triphosphate catabolic process 3 0.26785714285714285 0.3260881212751439 VPS4B, OLA1, ABCC6 751 21 13528 2.5733307970325283 1.0 0.9878826382571414 99.91247849890985 GOTERM_BP_FAT GO:0009154~purine ribonucleotide catabolic process 3 0.26785714285714285 0.36716575204022195 VPS4B, OLA1, ABCC6 751 23 13528 2.349562901638395 1.0 0.988861079767052 99.97150149109886 GOTERM_BP_FAT GO:0009143~nucleoside triphosphate catabolic process 3 0.26785714285714285 0.3873428265619751 VPS4B, OLA1, ABCC6 751 24 13528 2.251664447403462 1.0 0.9899768849534346 99.98401340122311 GOTERM_BP_FAT GO:0009261~ribonucleotide catabolic process 3 0.26785714285714285 0.4072309444222758 VPS4B, OLA1, ABCC6 751 25 13528 2.161597869507324 1.0 0.990948730362974 99.99112722561188 GOTERM_BP_FAT GO:0009166~nucleotide catabolic process 4 0.35714285714285715 0.5430120746542353 PDE5A, VPS4B, OLA1, ABCC6 751 51 13528 1.4128090650374665 1.0 0.9950792468993662 99.99991441978236 GOTERM_BP_FAT GO:0034655~nucleobase, nucleoside, nucleotide and nucleic acid catabolic process 4 0.35714285714285715 0.6310635540215259 PDE5A, VPS4B, OLA1, ABCC6 751 58 13528 1.2422976261536343 1.0 0.9972533627706059 99.99999812068505 GOTERM_BP_FAT GO:0034656~nucleobase, nucleoside and nucleotide catabolic process 4 0.35714285714285715 0.6310635540215259 PDE5A, VPS4B, OLA1, ABCC6 751 58 13528 1.2422976261536343 1.0 0.9972533627706059 99.99999812068505 GOTERM_BP_FAT GO:0044270~nitrogen compound catabolic process 4 0.35714285714285715 0.7259215962206695 PDE5A, VPS4B, OLA1, ABCC6 751 67 13528 1.0754218256255343 1.0 0.998666988848092 99.99999999064279 GOTERM_BP_FAT GO:0046700~heterocycle catabolic process 4 0.35714285714285715 0.8077166334502016 PDE5A, VPS4B, OLA1, ABCC6 751 77 13528 0.9357566534663738 1.0 0.9995612823582513 99.99999999998322 Annotation Cluster 129 Enrichment Score: 0.39780906496019086 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008376~acetylgalactosaminyltransferase activity 5 0.4464285714285714 0.09162456334636833 GALNT3, CHSY3, GALNT7, CHPF, GALNTL6 725 31 12983 2.8883203559510564 1.0 0.9489827126414584 77.4781098547813 GOTERM_MF_FAT GO:0004653~polypeptide N-acetylgalactosaminyltransferase activity 3 0.26785714285714285 0.26555573033642405 GALNT3, GALNT7, GALNTL6 725 18 12983 2.9845977011494256 1.0 0.9908554253352713 99.16683949029085 UP_SEQ_FEATURE region of interest:Catalytic subdomain B 3 0.26785714285714285 0.2705528588363417 GALNT3, GALNT7, GALNTL6 1024 19 19113 2.947111430921052 1.0 0.9999956748544769 99.62503927233907 UP_SEQ_FEATURE region of interest:Catalytic subdomain A 3 0.26785714285714285 0.2705528588363417 GALNT3, GALNT7, GALNTL6 1024 19 19113 2.947111430921052 1.0 0.9999956748544769 99.62503927233907 UP_SEQ_FEATURE domain:Ricin B-type lectin 3 0.26785714285714285 0.40905874301878076 GALNT3, GALNT7, GALNTL6 1024 26 19113 2.1536583533653846 1.0 0.9999978925619387 99.99099137347375 INTERPRO IPR000772:Ricin B lectin 3 0.26785714285714285 0.4434176137459754 GALNT3, GALNT7, GALNTL6 920 27 16659 2.0119565217391306 1.0 0.9998061090478133 99.99308177473887 SMART SM00458:RICIN 3 0.26785714285714285 0.45498934927429324 GALNT3, GALNT7, GALNTL6 513 27 9079 1.9664284167208141 1.0 0.9922153352262079 99.96609657866846 INTERPRO IPR001173:Glycosyl transferase, family 2 3 0.26785714285714285 0.46222647412805895 GALNT3, GALNT7, GALNTL6 920 28 16659 1.9401009316770186 1.0 0.9998703016454031 99.9960561258575 KEGG_PATHWAY hsa00512:O-Glycan biosynthesis 3 0.26785714285714285 0.5358682774914479 GALNT3, GALNT7, GALNTL6 301 30 5085 1.6893687707641196 1.0 0.9221834590370671 99.99083856798013 GOTERM_MF_FAT GO:0030145~manganese ion binding 9 0.8035714285714285 0.6327065649535172 GALNT3, PHLPP1, POLL, PPM1F, CDIPT, GALNT7, GALNTL6, BMPR2, PPP4C 725 154 12983 1.0465472458575906 1.0 0.9993632738770103 99.99998211852858 SP_PIR_KEYWORDS Lectin 8 0.7142857142857143 0.7501845778860422 GALNT3, DGCR2, GALNT7, NPTX2, ZG16, GALNTL6, COLEC12, LMAN1 1027 159 19235 0.9423551530071713 1.0 0.9797966290727236 99.99999984373375 SP_PIR_KEYWORDS glycosyltransferase 7 0.625 0.9743975495363978 GALNT3, TYMP, GALNT7, XYLT1, GALNTL6, PARP1, ALG12 1027 214 19235 0.6126409376734705 1.0 0.9996967527411321 100.0 Annotation Cluster 130 Enrichment Score: 0.3963244274194118 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0031349~positive regulation of defense response 8 0.7142857142857143 0.10907558785531317 TGM2, TLR3, TAC1, JAK2, LBP, HSPD1, IL21, CD226 751 73 13528 1.9740619812852271 1.0 0.967616226613153 87.26166362465403 GOTERM_BP_FAT GO:0050867~positive regulation of cell activation 10 0.8928571428571428 0.16241149690199455 TAC1, MALT1, ITPKB, JAK2, LBP, HSPD1, IL21, CD226, PDCD1LG2, IL2 751 111 13528 1.6228212233538466 1.0 0.9819088702045751 95.76558093395471 GOTERM_BP_FAT GO:0050865~regulation of cell activation 14 1.25 0.1738164728077254 SLA2, TAC1, MALT1, ITPKB, INHA, IL21, PDCD1LG2, BPI, CD274, JAK2, HSPD1, LBP, CD226, IL2 751 175 13528 1.4410652463382159 1.0 0.9852862612159309 96.68437340452462 GOTERM_BP_FAT GO:0002683~negative regulation of immune system process 8 0.7142857142857143 0.17620612895706783 BPI, SLA2, CD274, COL3A1, INHA, GREM1, PDCD1LG2, IL2 751 83 13528 1.736223188359296 1.0 0.9842382834755249 96.85136636566709 GOTERM_BP_FAT GO:0045088~regulation of innate immune response 6 0.5357142857142857 0.17840917535562695 SAMHD1, TLR3, LBP, HSPD1, IL21, CD226 751 54 13528 2.0014795088030777 1.0 0.9846269749974524 96.9982569041437 GOTERM_BP_FAT GO:0002695~negative regulation of leukocyte activation 6 0.5357142857142857 0.20764627570898422 BPI, SLA2, CD274, INHA, PDCD1LG2, IL2 751 57 13528 1.8961384820239682 1.0 0.9833371679953984 98.42739502383805 GOTERM_BP_FAT GO:0002694~regulation of leukocyte activation 13 1.1607142857142858 0.21068448950536042 SLA2, TAC1, ITPKB, MALT1, INHA, IL21, PDCD1LG2, BPI, CD274, HSPD1, LBP, CD226, IL2 751 166 13528 1.4106813405419278 1.0 0.9831620536439942 98.53157219814507 GOTERM_BP_FAT GO:0002699~positive regulation of immune effector process 5 0.4464285714285714 0.2258427795423493 MALT1, LBP, HSPD1, IL21, CD226 751 44 13528 2.0469676794576928 1.0 0.9824042958226361 98.96102401464539 GOTERM_BP_FAT GO:0032649~regulation of interferon-gamma production 4 0.35714285714285715 0.23034338770126905 TLR3, INHA, HSPD1, IL21 751 30 13528 2.401775410563693 1.0 0.9819992455462694 99.06366928169487 GOTERM_BP_FAT GO:0002696~positive regulation of leukocyte activation 9 0.8035714285714285 0.23417948269011 TAC1, MALT1, ITPKB, LBP, HSPD1, IL21, CD226, PDCD1LG2, IL2 751 106 13528 1.5294324548400873 1.0 0.9825605940615174 99.143525861157 GOTERM_BP_FAT GO:0050866~negative regulation of cell activation 6 0.5357142857142857 0.2487983966950528 BPI, SLA2, CD274, INHA, PDCD1LG2, IL2 751 61 13528 1.771801532383052 1.0 0.9829732684412159 99.39273724792704 GOTERM_BP_FAT GO:0045089~positive regulation of innate immune response 5 0.4464285714285714 0.25015522405365453 TLR3, LBP, HSPD1, IL21, CD226 751 46 13528 1.9579690846986626 1.0 0.9830534357138146 99.41201118876437 GOTERM_BP_FAT GO:0032755~positive regulation of interleukin-6 production 3 0.26785714285714285 0.28433811594414127 TLR3, LBP, HSPD1 751 19 13528 2.8442077230359524 1.0 0.9850057907059313 99.74423032459922 GOTERM_BP_FAT GO:0002705~positive regulation of leukocyte mediated immunity 4 0.35714285714285715 0.2911911697136773 MALT1, HSPD1, IL21, CD226 751 34 13528 2.1192135975562 1.0 0.9856460754604113 99.78457514344491 GOTERM_BP_FAT GO:0002708~positive regulation of lymphocyte mediated immunity 4 0.35714285714285715 0.2911911697136773 MALT1, HSPD1, IL21, CD226 751 34 13528 2.1192135975562 1.0 0.9856460754604113 99.78457514344491 GOTERM_BP_FAT GO:0032675~regulation of interleukin-6 production 4 0.35714285714285715 0.3220749149897021 BPI, TLR3, LBP, HSPD1 751 36 13528 2.0014795088030772 1.0 0.9877246963956805 99.902698545993 GOTERM_BP_FAT GO:0051250~negative regulation of lymphocyte activation 5 0.4464285714285714 0.35124712954911025 SLA2, CD274, INHA, PDCD1LG2, IL2 751 54 13528 1.667899590669231 1.0 0.9891868860642569 99.95560705657182 GOTERM_BP_FAT GO:0002706~regulation of lymphocyte mediated immunity 5 0.4464285714285714 0.35124712954911025 MALT1, HSPD1, IL21, CD226, IL2 751 54 13528 1.667899590669231 1.0 0.9891868860642569 99.95560705657182 GOTERM_BP_FAT GO:0001819~positive regulation of cytokine production 7 0.625 0.38208295144430515 TLR3, MALT1, JAK2, LBP, HSPD1, IL21, NLRP3 751 90 13528 1.4010356561621542 1.0 0.9896334840351603 99.9813794113608 GOTERM_BP_FAT GO:0050778~positive regulation of immune response 10 0.8928571428571428 0.4129851967535603 MAPK1, SLA2, PSEN2, TLR3, SH2B2, MALT1, LBP, HSPD1, IL21, CD226 751 145 13528 1.2422976261536343 1.0 0.9914480147542912 99.99254450076718 GOTERM_BP_FAT GO:0050870~positive regulation of T cell activation 6 0.5357142857142857 0.4140318586526262 MALT1, ITPKB, HSPD1, IL21, PDCD1LG2, IL2 751 76 13528 1.4221038615179762 1.0 0.9914526348355741 99.99277813923139 GOTERM_BP_FAT GO:0001817~regulation of cytokine production 12 1.0714285714285714 0.42137903821493844 TLR3, CIDEA, MALT1, INHA, NLRP3, IL21, TMED7, BPI, TICAM2, JAK2, CHRNA7, HSPD1, LBP 751 181 13528 1.194252966578632 1.0 0.9918721312709224 99.9942338827295 GOTERM_BP_FAT GO:0051249~regulation of lymphocyte activation 10 0.8928571428571428 0.43697827431368197 SLA2, CD274, TAC1, MALT1, ITPKB, INHA, HSPD1, IL21, PDCD1LG2, IL2 751 148 13528 1.217115917515385 1.0 0.9925302867089788 99.99645897545957 GOTERM_BP_FAT GO:0002703~regulation of leukocyte mediated immunity 5 0.4464285714285714 0.4402075660676469 MALT1, HSPD1, IL21, CD226, IL2 751 61 13528 1.4765012769858765 1.0 0.9926686151826412 99.99680434483778 GOTERM_BP_FAT GO:0002684~positive regulation of immune system process 15 1.3392857142857142 0.4490946807435034 SLA2, TAC1, TLR3, MALT1, ITPKB, IL21, PDCD1LG2, MAPK1, MIA3, PSEN2, SH2B2, HSPD1, LBP, CD226, IL2 751 238 13528 1.1352929986908211 1.0 0.992667745172272 99.99759804878055 GOTERM_BP_FAT GO:0051251~positive regulation of lymphocyte activation 7 0.625 0.45207006351553214 TAC1, MALT1, ITPKB, HSPD1, IL21, PDCD1LG2, IL2 751 97 13528 1.2999299902535453 1.0 0.9928836462208993 99.99781926259995 GOTERM_BP_FAT GO:0002824~positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 3 0.26785714285714285 0.501427341333422 MALT1, HSPD1, CD226 751 30 13528 1.8013315579227698 1.0 0.994380912767868 99.99959525159535 GOTERM_BP_FAT GO:0002821~positive regulation of adaptive immune response 3 0.26785714285714285 0.519086766779737 MALT1, HSPD1, CD226 751 31 13528 1.7432240883123578 1.0 0.9949040173348078 99.9997873013107 GOTERM_BP_FAT GO:0070664~negative regulation of leukocyte proliferation 3 0.26785714285714285 0.5363235366090169 CD274, PDCD1LG2, IL2 751 32 13528 1.6887483355525965 1.0 0.9952379010264989 99.99988909383956 GOTERM_BP_FAT GO:0050672~negative regulation of lymphocyte proliferation 3 0.26785714285714285 0.5363235366090169 CD274, PDCD1LG2, IL2 751 32 13528 1.6887483355525965 1.0 0.9952379010264989 99.99988909383956 GOTERM_BP_FAT GO:0032945~negative regulation of mononuclear cell proliferation 3 0.26785714285714285 0.5363235366090169 CD274, PDCD1LG2, IL2 751 32 13528 1.6887483355525965 1.0 0.9952379010264989 99.99988909383956 GOTERM_BP_FAT GO:0045621~positive regulation of lymphocyte differentiation 3 0.26785714285714285 0.5854336720661045 ITPKB, IL21, IL2 751 35 13528 1.5439984782195169 1.0 0.9960729596140963 99.99998495092451 GOTERM_BP_FAT GO:0050671~positive regulation of lymphocyte proliferation 4 0.35714285714285715 0.5948108191159199 TAC1, IL21, PDCD1LG2, IL2 751 55 13528 1.3100593148529234 1.0 0.9961881085397631 99.9999899945012 GOTERM_BP_FAT GO:0002822~regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 4 0.35714285714285715 0.5948108191159199 MALT1, HSPD1, CD226, IL2 751 55 13528 1.3100593148529234 1.0 0.9961881085397631 99.9999899945012 GOTERM_BP_FAT GO:0070665~positive regulation of leukocyte proliferation 4 0.35714285714285715 0.6071484092379518 TAC1, IL21, PDCD1LG2, IL2 751 56 13528 1.286665398516264 1.0 0.9966429453318971 99.99999423702566 GOTERM_BP_FAT GO:0002819~regulation of adaptive immune response 4 0.35714285714285715 0.6071484092379518 MALT1, HSPD1, CD226, IL2 751 56 13528 1.286665398516264 1.0 0.9966429453318971 99.99999423702566 GOTERM_BP_FAT GO:0032946~positive regulation of mononuclear cell proliferation 4 0.35714285714285715 0.6071484092379518 TAC1, IL21, PDCD1LG2, IL2 751 56 13528 1.286665398516264 1.0 0.9966429453318971 99.99999423702566 GOTERM_BP_FAT GO:0050863~regulation of T cell activation 7 0.625 0.6361333944349448 CD274, MALT1, ITPKB, HSPD1, IL21, PDCD1LG2, IL2 751 117 13528 1.0777197355093495 1.0 0.9973373575304527 99.99999853179466 GOTERM_BP_FAT GO:0042102~positive regulation of T cell proliferation 3 0.26785714285714285 0.6447617437638916 IL21, PDCD1LG2, IL2 751 39 13528 1.3856396599405922 1.0 0.9975033995637904 99.99999904315868 GOTERM_BP_FAT GO:0002697~regulation of immune effector process 6 0.5357142857142857 0.6655992560359609 MALT1, LBP, HSPD1, IL21, CD226, IL2 751 101 13528 1.0700979552016454 1.0 0.997891944291876 99.99999967456056 GOTERM_BP_FAT GO:0002700~regulation of production of molecular mediator of immune response 3 0.26785714285714285 0.6718134763314597 MALT1, IL21, IL2 751 41 13528 1.3180474814069045 1.0 0.9980294565286589 99.99999976712174 GOTERM_BP_FAT GO:0042129~regulation of T cell proliferation 4 0.35714285714285715 0.6758035376160756 CD274, IL21, PDCD1LG2, IL2 751 62 13528 1.1621493922082387 1.0 0.9980884165956428 99.99999981278125 GOTERM_BP_FAT GO:0050670~regulation of lymphocyte proliferation 5 0.4464285714285714 0.6827915684408095 CD274, TAC1, IL21, PDCD1LG2, IL2 751 83 13528 1.08513949272456 1.0 0.9981953098959779 99.99999987308571 GOTERM_BP_FAT GO:0045619~regulation of lymphocyte differentiation 4 0.35714285714285715 0.6863409912708732 ITPKB, INHA, IL21, IL2 751 63 13528 1.1437025764589015 1.0 0.9982381336236708 99.99999989617008 GOTERM_BP_FAT GO:0070663~regulation of leukocyte proliferation 5 0.4464285714285714 0.691868072674309 CD274, TAC1, IL21, PDCD1LG2, IL2 751 84 13528 1.07222116543022 1.0 0.9983184158768698 99.99999992439137 GOTERM_BP_FAT GO:0032944~regulation of mononuclear cell proliferation 5 0.4464285714285714 0.691868072674309 CD274, TAC1, IL21, PDCD1LG2, IL2 751 84 13528 1.07222116543022 1.0 0.9983184158768698 99.99999992439137 GOTERM_BP_FAT GO:0051240~positive regulation of multicellular organismal process 13 1.1607142857142858 0.7069445958362 BMPR2, TAC1, TLR3, MALT1, NLRP3, IL21, GHRH, BCL2, PSEN2, MC4R, JAK2, HSPD1, LBP 751 244 13528 0.9597258300408198 1.0 0.9984880724848002 99.99999996910624 GOTERM_BP_FAT GO:0050864~regulation of B cell activation 3 0.26785714285714285 0.7827760401224466 SLA2, INHA, IL2 751 51 13528 1.0596067987780997 1.0 0.9994112779525123 99.99999999985216 Annotation Cluster 131 Enrichment Score: 0.39596195367190695 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0050679~positive regulation of epithelial cell proliferation 5 0.4464285714285714 0.19065231224939572 LAMA1, VEGFC, DLX6, DLX5, IHH 751 41 13528 2.1967458023448407 1.0 0.9841331399108887 97.70362705688565 GOTERM_BP_FAT GO:0050678~regulation of epithelial cell proliferation 6 0.5357142857142857 0.35823923256156515 LAMA1, VEGFC, DLX6, DLX5, CDK6, IHH 751 71 13528 1.5222520207798054 1.0 0.9885642342283342 99.9634108697353 GOTERM_BP_FAT GO:0030855~epithelial cell differentiation 5 0.4464285714285714 0.9499459954835944 LAMA1, DLX6, DLX5, FZD1, DHRS9 751 137 13528 0.6574202766141495 1.0 0.9999943983137792 100.0 Annotation Cluster 132 Enrichment Score: 0.39512103600547377 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051651~maintenance of location in cell 5 0.4464285714285714 0.2749851928598685 SRI, KDELR2, SEH1L, NDC80, TACC3 751 48 13528 1.876387039502885 1.0 0.9839326400454799 99.67755619672344 GOTERM_BP_FAT GO:0032507~maintenance of protein location in cell 4 0.35714285714285715 0.39893272355193987 KDELR2, SEH1L, NDC80, TACC3 751 41 13528 1.7573966418758729 1.0 0.9904918093893557 99.98862961100954 GOTERM_BP_FAT GO:0051235~maintenance of location 5 0.4464285714285714 0.47733081313688175 SRI, KDELR2, SEH1L, NDC80, TACC3 751 64 13528 1.4072902796271636 1.0 0.9934854568536916 99.99906049952139 GOTERM_BP_FAT GO:0045185~maintenance of protein location 4 0.35714285714285715 0.5017500387973651 KDELR2, SEH1L, NDC80, TACC3 751 48 13528 1.501109631602308 1.0 0.9943294218838696 99.99959990001346 Annotation Cluster 133 Enrichment Score: 0.3949226509471111 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR018316:Tubulin/FtsZ, 2-layer sandwich domain 3 0.26785714285714285 0.34446998334290113 TUBB6, TUBA4A, TUBA4B 920 22 16659 2.4692193675889325 1.0 0.9992543307236836 99.89960488928914 INTERPRO IPR003008:Tubulin/FtsZ, GTPase domain 3 0.26785714285714285 0.3849215491373238 TUBB6, TUBA4A, TUBA4B 920 24 16659 2.2634510869565214 1.0 0.9995828289409534 99.96455935414392 INTERPRO IPR000217:Tubulin 3 0.26785714285714285 0.3849215491373238 TUBB6, TUBA4A, TUBA4B 920 24 16659 2.2634510869565214 1.0 0.9995828289409534 99.96455935414392 GOTERM_BP_FAT GO:0051258~protein polymerization 4 0.35714285714285715 0.5157195110373526 RAC1, TUBB6, TUBA4A, TUBA4B 751 49 13528 1.4704747411614447 1.0 0.9949287732781553 99.99975910527525 Annotation Cluster 134 Enrichment Score: 0.3917959107222072 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:t-SNARE coiled-coil homology 3 0.26785714285714285 0.3309772146886972 SNAP29, BET1, ABI2 1024 22 19113 2.5452325994318183 1.0 0.9999980484890173 99.91889947022098 INTERPRO IPR000727:Target SNARE coiled-coil region 3 0.26785714285714285 0.4434176137459754 SNAP29, BET1, ABI2 920 27 16659 2.0119565217391306 1.0 0.9998061090478133 99.99308177473887 SMART SM00397:t_SNARE 3 0.26785714285714285 0.45498934927429324 SNAP29, BET1, ABI2 513 27 9079 1.9664284167208141 1.0 0.9922153352262079 99.96609657866846 Annotation Cluster 135 Enrichment Score: 0.3882219016454188 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032989~cellular component morphogenesis 27 2.410714285714286 0.21930961716068167 ALS2, BBS5, BBS7, FIS1, NDE1, BCL2, RAC1, OBSL1, SPON2, NFATC1, ACTB, ACTC1, PTPRM, PCNT, RTN4R, NDC80, STRADB, AFG3L2, LAMA1, SEMA6A, EPHA4, DLX5, MYH11, RELN, JAK2, GFRA3, ADD1 751 397 13528 1.225086953751002 1.0 0.9841451999723794 98.79296749978319 GOTERM_BP_FAT GO:0032990~cell part morphogenesis 18 1.607142857142857 0.2572039880466719 ACTB, ALS2, BBS5, PTPRM, BBS7, PCNT, RTN4R, AFG3L2, SEMA6A, FIS1, EPHA4, BCL2, DLX5, RAC1, JAK2, RELN, SPON2, GFRA3 751 256 13528 1.2665612516644473 1.0 0.9835294284493938 99.50319165059128 GOTERM_BP_FAT GO:0007409~axonogenesis 14 1.25 0.27389925961235373 ACTB, ALS2, PTPRM, RTN4R, AFG3L2, SEMA6A, EPHA4, DLX5, BCL2, RAC1, JAK2, RELN, SPON2, GFRA3 751 193 13528 1.3066653788040816 1.0 0.9839324233420025 99.66883020614577 GOTERM_BP_FAT GO:0048858~cell projection morphogenesis 17 1.5178571428571428 0.290557069332011 ACTB, ALS2, BBS5, PTPRM, BBS7, PCNT, RTN4R, AFG3L2, SEMA6A, EPHA4, BCL2, DLX5, RAC1, JAK2, RELN, SPON2, GFRA3 751 245 13528 1.2499035299872279 1.0 0.9857598070811222 99.78111082656763 GOTERM_BP_FAT GO:0000902~cell morphogenesis 23 2.0535714285714284 0.3373187158649231 ACTB, ALS2, BBS5, PTPRM, BBS7, PCNT, RTN4R, NDC80, STRADB, AFG3L2, LAMA1, SEMA6A, EPHA4, NDE1, BCL2, DLX5, RAC1, JAK2, RELN, SPON2, ADD1, GFRA3, NFATC1 751 356 13528 1.1637816245006658 1.0 0.9883992868365595 99.93515086731034 GOTERM_BP_FAT GO:0048667~cell morphogenesis involved in neuron differentiation 14 1.25 0.3751061067345252 ACTB, ALS2, PTPRM, RTN4R, AFG3L2, SEMA6A, EPHA4, DLX5, BCL2, RAC1, JAK2, RELN, SPON2, GFRA3 751 209 13528 1.206633579469798 1.0 0.9888184619367785 99.97724966647792 GOTERM_BP_FAT GO:0048812~neuron projection morphogenesis 14 1.25 0.4012875705632229 ACTB, ALS2, PTPRM, RTN4R, AFG3L2, SEMA6A, EPHA4, DLX5, BCL2, RAC1, JAK2, RELN, SPON2, GFRA3 751 213 13528 1.1839737939398485 1.0 0.9905395723528637 99.9893986818329 GOTERM_BP_FAT GO:0000904~cell morphogenesis involved in differentiation 15 1.3392857142857142 0.49872366884183916 ACTB, ALS2, PTPRM, RTN4R, AFG3L2, SEMA6A, EPHA4, BCL2, DLX5, RAC1, JAK2, RELN, SPON2, GFRA3, NFATC1 751 244 13528 1.1073759577394076 1.0 0.9944688514448814 99.99955425248189 GOTERM_BP_FAT GO:0007411~axon guidance 7 0.625 0.548271646886354 EPHA4, SEMA6A, PTPRM, RAC1, RELN, SPON2, GFRA3 751 107 13528 1.1784412061176999 1.0 0.9952679229385122 99.99993038862922 GOTERM_BP_FAT GO:0031175~neuron projection development 15 1.3392857142857142 0.5605764222371605 ACTB, ALS2, PTPRM, RTN4R, ABI2, AFG3L2, SEMA6A, EPHA4, BCL2, DLX5, RAC1, JAK2, RELN, SPON2, GFRA3 751 256 13528 1.0554677097203726 1.0 0.9954594210453388 99.99995746995964 GOTERM_BP_FAT GO:0048666~neuron development 19 1.6964285714285714 0.6102405263629772 ACTB, ALS2, SCLT1, PTPRM, HTT, RTN4R, ABI2, AFG3L2, SALL3, GNGT1, SEMA6A, EPHA4, BCL2, DLX5, RAC1, JAK2, RELN, SPON2, GFRA3 751 339 13528 1.0095958584227913 1.0 0.9967190399215567 99.99999499482307 GOTERM_BP_FAT GO:0030182~neuron differentiation 24 2.142857142857143 0.63787490704447 ACTB, ALS2, SCLT1, PTPRM, HTT, NNAT, RTN4R, ABI2, AFG3L2, SALL3, DLX2, GNGT1, SEMA6A, EPHA4, GPC2, DLX1, BCL2, DLX5, RAC1, JAK2, RELN, CUX1, SPON2, GFRA3 751 438 13528 0.9870309906426135 1.0 0.9973783468812105 99.99999865223636 GOTERM_BP_FAT GO:0030030~cell projection organization 20 1.7857142857142856 0.6600550514583328 ACTB, ALS2, BBS5, PTPRM, BBS7, BAIAP2L1, PCNT, RTN4R, ABI2, AFG3L2, SEMA6A, EPHA4, ITGA6, BCL2, DLX5, RAC1, JAK2, RELN, SPON2, GFRA3 751 368 13528 0.9789845423493313 1.0 0.9978000968823098 99.99999956360591 Annotation Cluster 136 Enrichment Score: 0.38569025804943297 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS chromatin regulator 15 1.3392857142857142 0.24779185204720805 BRD1, BRCC3, FAM175A, RBL1, SMYD3, HIRA, HDAC10, PRDM6, PRDM5, ACTL6B, KDM4C, TLK1, KDM3B, CHD6, BRD8 1027 213 19235 1.318965399015319 1.0 0.8350789992479573 98.44331777880335 GOTERM_BP_FAT GO:0016568~chromatin modification 18 1.607142857142857 0.3672149813019091 BRD1, BRCC3, FAM175A, RBL1, SMYD3, HDAC10, HIRA, HAT1, CHD1L, PRDM6, PRDM5, ACTL6B, KDM4C, TLK1, KDM3B, CHD6, SMARCA2, BRD8 751 274 13528 1.1833564979054692 1.0 0.9886906336443401 99.97154101768231 GOTERM_BP_FAT GO:0051276~chromosome organization 29 2.5892857142857144 0.44698491531399015 HMGB2, FAM175A, HIRA, HAT1, CHD1L, SEH1L, ACTL6B, STAG3, TLK1, HIRIP3, KDM3B, CHD6, BRD8, BRD1, SMCHD1, BRCC3, SGOL2, RBL1, SMYD3, HDAC10, CDC23, NDC80, MAD2L1, PRDM6, PRDM5, KDM4C, NCAPH2, PARP1, SMARCA2 751 485 13528 1.0770848490672231 1.0 0.992651735458471 99.99742853632215 GOTERM_BP_FAT GO:0006325~chromatin organization 20 1.7857142857142856 0.704593590657952 BRD1, HMGB2, BRCC3, FAM175A, RBL1, SMYD3, HDAC10, HIRA, HAT1, CHD1L, PRDM6, PRDM5, KDM4C, ACTL6B, TLK1, HIRIP3, KDM3B, CHD6, SMARCA2, BRD8 751 378 13528 0.9530854803824178 1.0 0.9985181895479606 99.99999996437275 Annotation Cluster 137 Enrichment Score: 0.37917943766347884 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007346~regulation of mitotic cell cycle 12 1.0714285714285714 0.22263321104743225 MAEA, MAD2L1, PSMG2, BCL2, CDC23, RANBP1, ANLN, PIM3, ASNS, ZNF655, CDC25C, CCNA2 751 152 13528 1.4221038615179762 1.0 0.9828846512394633 98.88143198981167 GOTERM_BP_FAT GO:0030071~regulation of mitotic metaphase/anaphase transition 3 0.26785714285714285 0.34673430736531674 MAD2L1, PSMG2, CDC23 751 22 13528 2.456361215349231 1.0 0.989143614306072 99.94976282593954 GOTERM_BP_FAT GO:0010564~regulation of cell cycle process 8 0.7142857142857143 0.44660782062010324 PLK4, MAD2L1, PSMG2, CEP76, CDC23, RANBP1, ANLN, CDC25C 751 114 13528 1.264092321349312 1.0 0.9927185065449012 99.99739707278457 GOTERM_BP_FAT GO:0007088~regulation of mitosis 4 0.35714285714285715 0.6071484092379518 MAD2L1, PSMG2, CDC23, CDC25C 751 56 13528 1.286665398516264 1.0 0.9966429453318971 99.99999423702566 GOTERM_BP_FAT GO:0051783~regulation of nuclear division 4 0.35714285714285715 0.6071484092379518 MAD2L1, PSMG2, CDC23, CDC25C 751 56 13528 1.286665398516264 1.0 0.9966429453318971 99.99999423702566 Annotation Cluster 138 Enrichment Score: 0.3739940811297287 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:WD 12 3 0.26785714285714285 0.3309772146886972 DMXL1, WDR17, WDR64 1024 22 19113 2.5452325994318183 1.0 0.9999980484890173 99.91889947022098 UP_SEQ_FEATURE repeat:WD 8 5 0.4464285714285714 0.4013384732142329 WDR75, DMXL1, WDR17, WDR64, HIRA 1024 60 19113 1.555419921875 1.0 0.9999980076192672 99.98866359139163 UP_SEQ_FEATURE repeat:WD 9 4 0.35714285714285715 0.4211432587689184 WDR75, DMXL1, WDR17, WDR64 1024 44 19113 1.6968217329545456 1.0 0.9999973540649136 99.99375162860183 UP_SEQ_FEATURE repeat:WD 11 3 0.26785714285714285 0.48242487676486906 DMXL1, WDR17, WDR64 1024 30 19113 1.86650390625 1.0 0.9999994548674384 99.99913854804863 UP_SEQ_FEATURE repeat:WD 10 3 0.26785714285714285 0.4998746987119485 DMXL1, WDR17, WDR64 1024 31 19113 1.8062941028225807 1.0 0.9999997077788465 99.99953065958842 Annotation Cluster 139 Enrichment Score: 0.3706745625892481 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0042165~neurotransmitter binding 9 0.8035714285714285 0.21604883611358022 QRFPR, CHRM5, ACHE, GALR1, GLRA3, MC2R, CHRNA7, NPY6R, CHRNA1 725 103 12983 1.5647405423501841 1.0 0.9898239875342837 97.70812233650102 GOTERM_MF_FAT GO:0030594~neurotransmitter receptor activity 8 0.7142857142857143 0.27888823332606194 QRFPR, CHRM5, GALR1, GLRA3, MC2R, CHRNA7, NPY6R, CHRNA1 725 95 12983 1.5080072595281304 1.0 0.9904109759976156 99.37293924547323 GOTERM_MF_FAT GO:0008188~neuropeptide receptor activity 4 0.35714285714285715 0.38728363017948114 QRFPR, GALR1, MC2R, NPY6R 725 40 12983 1.790758620689655 1.0 0.9956817544393224 99.94988941143347 GOTERM_MF_FAT GO:0042923~neuropeptide binding 4 0.35714285714285715 0.4025927812737434 QRFPR, GALR1, MC2R, NPY6R 725 41 12983 1.747081581160639 1.0 0.9956900777070927 99.9661572363916 GOTERM_MF_FAT GO:0042562~hormone binding 4 0.35714285714285715 0.5197307996690993 CALCR, MC2R, MC4R, MC5R 725 49 12983 1.4618437719915551 1.0 0.9982682999756888 99.99885413901144 GOTERM_MF_FAT GO:0042277~peptide binding 12 1.0714285714285714 0.5833312870700496 QRFPR, CALCR, KDELR2, PPIG, GALR1, PPIC, MC2R, MC4R, MC5R, NPSR1, NPY6R, PGGT1B 725 203 12983 1.058576524545609 1.0 0.9989278425147103 99.9998734898054 GOTERM_MF_FAT GO:0001653~peptide receptor activity 7 0.625 0.6166180935741554 QRFPR, GALR1, MC2R, MC4R, MC5R, NPSR1, NPY6R 725 114 12983 1.099588626739262 1.0 0.9992739869638941 99.99996522908936 GOTERM_MF_FAT GO:0008528~peptide receptor activity, G-protein coupled 7 0.625 0.6166180935741554 QRFPR, GALR1, MC2R, MC4R, MC5R, NPSR1, NPY6R 725 114 12983 1.099588626739262 1.0 0.9992739869638941 99.99996522908936 Annotation Cluster 140 Enrichment Score: 0.36683493414158835 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007267~cell-cell signaling 37 3.303571428571429 0.33914322640025885 SEPT5, ALS2, INSL4, ACHE, GAL3ST4, GLRA3, TAC1, AKAP9, COMT, GREM1, VGF, GJA5, MBP, ADCYAP1, TNFRSF11A, BHLHA15, NPTX2, RAPGEF4, CHRNA1, WNT6, GAD1, SLC1A1, IHH, GJD2, IL3, DLGAP1, HTT, DLGAP4, PI4KA, FZD1, INHA, MAPK1, DOC2A, GHRH, MC4R, LRP2, IL2 751 600 13528 1.1108211273857078 1.0 0.9883405263455054 99.9382634822199 GOTERM_BP_FAT GO:0019226~transmission of nerve impulse 22 1.9642857142857142 0.3966675541358199 GJD2, ALS2, SEPT5, DLGAP1, ACHE, SCN1A, GLRA3, PI4KA, TAC1, AKAP9, COMT, AFG3L2, GJC3, MBP, MAPK1, CHRM5, DOC2A, NPTX2, NAB1, CHRNA1, GAD1, SLC1A1 751 350 13528 1.1322655506943125 1.0 0.9903089549887286 99.98784037283696 GOTERM_BP_FAT GO:0007268~synaptic transmission 17 1.5178571428571428 0.5897736589829163 ALS2, SEPT5, GJD2, DLGAP1, ACHE, GLRA3, PI4KA, TAC1, AKAP9, COMT, MBP, MAPK1, DOC2A, NPTX2, CHRNA1, GAD1, SLC1A1 751 298 13528 1.0276052511639961 1.0 0.9961820089824136 99.9999875270828 Annotation Cluster 141 Enrichment Score: 0.3661365657398663 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009205~purine ribonucleoside triphosphate metabolic process 10 0.8928571428571428 0.2008082812185982 ALDOA, NME5, ATP5J2, ATP9B, ATP8B1, AK3, VPS4B, OLA1, ATP5G3, ABCC6 751 117 13528 1.5395996221562134 1.0 0.983875733980521 98.16684232903881 GOTERM_BP_FAT GO:0009199~ribonucleoside triphosphate metabolic process 10 0.8928571428571428 0.20755182681805576 ALDOA, NME5, ATP5J2, ATP9B, ATP8B1, AK3, VPS4B, OLA1, ATP5G3, ABCC6 751 118 13528 1.5265521677311609 1.0 0.9837345427854348 98.42404728460623 GOTERM_BP_FAT GO:0046034~ATP metabolic process 9 0.8035714285714285 0.22657314751280977 ALDOA, ATP5J2, ATP9B, ATP8B1, AK3, VPS4B, OLA1, ATP5G3, ABCC6 751 105 13528 1.5439984782195166 1.0 0.9818517012031401 98.97837362318278 GOTERM_BP_FAT GO:0009144~purine nucleoside triphosphate metabolic process 10 0.8928571428571428 0.23540233635017657 ALDOA, NME5, ATP5J2, ATP9B, ATP8B1, AK3, VPS4B, OLA1, ATP5G3, ABCC6 751 122 13528 1.4765012769858765 1.0 0.9825953270091532 99.1675999901807 GOTERM_BP_FAT GO:0009150~purine ribonucleotide metabolic process 11 0.9821428571428571 0.2356168191654476 ALDOA, ADSS, NME5, ATP5J2, ATP9B, ATP8B1, AK3, VPS4B, OLA1, ATP5G3, ABCC6 751 138 13528 1.4358439954456859 1.0 0.9822826616319329 99.17175607427492 GOTERM_BP_FAT GO:0009259~ribonucleotide metabolic process 11 0.9821428571428571 0.29834129260204467 ALDOA, ADSS, NME5, ATP5J2, ATP9B, ATP8B1, AK3, VPS4B, OLA1, ATP5G3, ABCC6 751 147 13528 1.3479351793979908 1.0 0.986065099256094 99.8202211958499 GOTERM_BP_FAT GO:0009141~nucleoside triphosphate metabolic process 10 0.8928571428571428 0.30230319062336136 ALDOA, NME5, ATP5J2, ATP9B, ATP8B1, AK3, VPS4B, OLA1, ATP5G3, ABCC6 751 131 13528 1.3750622579563125 1.0 0.9862334362882558 99.83749590324986 GOTERM_BP_FAT GO:0006163~purine nucleotide metabolic process 12 1.0714285714285714 0.4572427933700747 ALDOA, ADSS, NME5, ATP5J2, ATP9B, PDE5A, ATP8B1, AK3, VPS4B, OLA1, ATP5G3, ABCC6 751 186 13528 1.1621493922082384 1.0 0.9928109979639029 99.99815876689769 GOTERM_BP_FAT GO:0009206~purine ribonucleoside triphosphate biosynthetic process 7 0.625 0.4619531272093341 ALDOA, NME5, ATP5J2, ATP9B, ATP8B1, AK3, ATP5G3 751 98 13528 1.2866653985162642 1.0 0.9929004838449121 99.99842394254456 GOTERM_BP_FAT GO:0009201~ribonucleoside triphosphate biosynthetic process 7 0.625 0.4717905970961698 ALDOA, NME5, ATP5J2, ATP9B, ATP8B1, AK3, ATP5G3 751 99 13528 1.273668778329231 1.0 0.9933169750258427 99.99886604746516 GOTERM_BP_FAT GO:0009145~purine nucleoside triphosphate biosynthetic process 7 0.625 0.4717905970961698 ALDOA, NME5, ATP5J2, ATP9B, ATP8B1, AK3, ATP5G3 751 99 13528 1.273668778329231 1.0 0.9933169750258427 99.99886604746516 GOTERM_BP_FAT GO:0009152~purine ribonucleotide biosynthetic process 8 0.7142857142857143 0.4738378637060062 ALDOA, ADSS, NME5, ATP5J2, ATP9B, ATP8B1, AK3, ATP5G3 751 117 13528 1.2316796977249709 1.0 0.9933303571207825 99.998941951794 GOTERM_BP_FAT GO:0009142~nucleoside triphosphate biosynthetic process 7 0.625 0.5009789250438401 ALDOA, NME5, ATP5J2, ATP9B, ATP8B1, AK3, ATP5G3 751 102 13528 1.236207931907783 1.0 0.9944217459535258 99.999588707516 GOTERM_BP_FAT GO:0009260~ribonucleotide biosynthetic process 8 0.7142857142857143 0.5358252846089807 ALDOA, ADSS, NME5, ATP5J2, ATP9B, ATP8B1, AK3, ATP5G3 751 124 13528 1.1621493922082387 1.0 0.9952664442882737 99.9998869482725 GOTERM_BP_FAT GO:0006754~ATP biosynthetic process 6 0.5357142857142857 0.5531663816345158 ALDOA, ATP5J2, ATP9B, ATP8B1, AK3, ATP5G3 751 89 13528 1.214380825565912 1.0 0.9953056762220782 99.99994268536832 GOTERM_BP_FAT GO:0006164~purine nucleotide biosynthetic process 8 0.7142857142857143 0.7197296026674651 ALDOA, ADSS, NME5, ATP5J2, ATP9B, ATP8B1, AK3, ATP5G3 751 148 13528 0.9736927340123079 1.0 0.9985937811655633 99.99999998606052 GOTERM_BP_FAT GO:0044271~nitrogen compound biosynthetic process 17 1.5178571428571428 0.7244200390820333 ALDOA, ADSS, ATP5J2, HTT, AK3, NFS1, ASNSD1, ASNS, CDO1, AGXT, ATP5G3, TYMS, NME5, PYCR2, ATP9B, ATP8B1, ENOPH1 751 325 13528 0.9422349687596026 1.0 0.9986458756009001 99.99999998968475 GOTERM_BP_FAT GO:0009165~nucleotide biosynthetic process 9 0.8035714285714285 0.8161155600156607 ALDOA, TYMS, ADSS, NME5, ATP5J2, ATP9B, ATP8B1, AK3, ATP5G3 751 186 13528 0.8716120441561788 1.0 0.9996093987559421 99.99999999999244 GOTERM_BP_FAT GO:0034404~nucleobase, nucleoside and nucleotide biosynthetic process 9 0.8035714285714285 0.8457615657669276 ALDOA, TYMS, ADSS, NME5, ATP5J2, ATP9B, ATP8B1, AK3, ATP5G3 751 193 13528 0.8399991720883382 1.0 0.9997831023364556 99.99999999999967 GOTERM_BP_FAT GO:0034654~nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process 9 0.8035714285714285 0.8457615657669276 ALDOA, TYMS, ADSS, NME5, ATP5J2, ATP9B, ATP8B1, AK3, ATP5G3 751 193 13528 0.8399991720883382 1.0 0.9997831023364556 99.99999999999967 Annotation Cluster 142 Enrichment Score: 0.3631770999053857 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030334~regulation of cell migration 12 1.0714285714285714 0.33579421120534547 LAMA1, MAPK1, VEGFC, MIA3, PTPRM, NF2, BCL2, RAC1, TAC1, JAK2, TRIP6, GREM1 751 169 13528 1.2790519937913156 1.0 0.9887181401246027 99.93243705368836 GOTERM_BP_FAT GO:0030335~positive regulation of cell migration 7 0.625 0.3720422112911304 MAPK1, VEGFC, MIA3, BCL2, TAC1, JAK2, TRIP6 751 89 13528 1.4167776298268977 1.0 0.9888173397819937 99.97517524229623 GOTERM_BP_FAT GO:0030336~negative regulation of cell migration 5 0.4464285714285714 0.38961657217886264 MIA3, PTPRM, NF2, BCL2, GREM1 751 57 13528 1.58011540168664 1.0 0.9901675856437008 99.98503948011313 GOTERM_BP_FAT GO:0040013~negative regulation of locomotion 5 0.4464285714285714 0.4402075660676469 MIA3, PTPRM, NF2, BCL2, GREM1 751 61 13528 1.4765012769858765 1.0 0.9926686151826412 99.99680434483778 GOTERM_BP_FAT GO:0040017~positive regulation of locomotion 7 0.625 0.4619531272093341 MAPK1, VEGFC, MIA3, BCL2, TAC1, JAK2, TRIP6 751 98 13528 1.2866653985162642 1.0 0.9929004838449121 99.99842394254456 GOTERM_BP_FAT GO:0051272~positive regulation of cell motion 7 0.625 0.4619531272093341 MAPK1, VEGFC, MIA3, BCL2, TAC1, JAK2, TRIP6 751 98 13528 1.2866653985162642 1.0 0.9929004838449121 99.99842394254456 GOTERM_BP_FAT GO:0051271~negative regulation of cell motion 5 0.4464285714285714 0.4650544644135546 MIA3, PTPRM, NF2, BCL2, GREM1 751 63 13528 1.4296282205736266 1.0 0.9929232962050184 99.99857838654383 GOTERM_BP_FAT GO:0040012~regulation of locomotion 12 1.0714285714285714 0.4998523849994845 LAMA1, MAPK1, VEGFC, MIA3, PTPRM, NF2, BCL2, RAC1, TAC1, JAK2, TRIP6, GREM1 751 192 13528 1.125832223701731 1.0 0.9944842930953388 99.99957182363565 GOTERM_BP_FAT GO:0051270~regulation of cell motion 12 1.0714285714285714 0.506879054675357 LAMA1, MAPK1, VEGFC, MIA3, PTPRM, NF2, BCL2, RAC1, TAC1, JAK2, TRIP6, GREM1 751 193 13528 1.1199988961177842 1.0 0.9946743355341762 99.99966734473794 Annotation Cluster 143 Enrichment Score: 0.36087008892171735 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0055002~striated muscle cell development 6 0.5357142857142857 0.1598514172758459 ALS2, ACTC1, MYH11, OBSL1, CHRNA1, AFG3L2 751 52 13528 2.078459489910888 1.0 0.9824491278156547 95.5286352723849 GOTERM_BP_FAT GO:0007517~muscle organ development 16 1.4285714285714286 0.1940525686166459 ALS2, SRI, CPT1B, ACHE, ACTC1, CHKB, MSTN, MOV10L1, TBX1, AFG3L2, MAPK12, SPEG, NDUFV2, MYH11, OBSL1, SGCE, CHRNA1 751 211 13528 1.3659386221215315 1.0 0.9840444877621815 97.86979331403778 GOTERM_BP_FAT GO:0055001~muscle cell development 6 0.5357142857142857 0.1977277202689705 ALS2, ACTC1, MYH11, OBSL1, CHRNA1, AFG3L2 751 56 13528 1.9299980977743958 1.0 0.984512621625945 98.03660037117544 GOTERM_BP_FAT GO:0007528~neuromuscular junction development 3 0.26785714285714285 0.3052723359325553 ALS2, CHRNA1, AFG3L2 751 20 13528 2.7019973368841543 1.0 0.986420887367379 99.849401625874 GOTERM_BP_FAT GO:0048747~muscle fiber development 4 0.35714285714285715 0.30661847322071817 ALS2, MYH11, CHRNA1, AFG3L2 751 35 13528 2.058664637626023 1.0 0.9862330908720798 99.85452365571125 GOTERM_BP_FAT GO:0030239~myofibril assembly 3 0.26785714285714285 0.3260881212751439 ACTC1, MYH11, OBSL1 751 21 13528 2.5733307970325283 1.0 0.9878826382571414 99.91247849890985 GOTERM_BP_FAT GO:0042692~muscle cell differentiation 9 0.8035714285714285 0.356382984866204 ALS2, ACTC1, MAPK12, SPEG, MYH11, OBSL1, CAPN2, CHRNA1, AFG3L2 751 121 13528 1.3398333901904897 1.0 0.9887913256966518 99.96147603778516 GOTERM_BP_FAT GO:0051146~striated muscle cell differentiation 7 0.625 0.3620101712648382 ALS2, ACTC1, MYH11, OBSL1, CAPN2, CHRNA1, AFG3L2 751 88 13528 1.432877375620385 1.0 0.9886818694907225 99.96706256548045 GOTERM_BP_FAT GO:0048741~skeletal muscle fiber development 3 0.26785714285714285 0.46488239648518154 ALS2, CHRNA1, AFG3L2 751 28 13528 1.9299980977743958 1.0 0.9930054318474782 99.99857020628914 GOTERM_BP_FAT GO:0031032~actomyosin structure organization 3 0.26785714285714285 0.46488239648518154 ACTC1, MYH11, OBSL1 751 28 13528 1.9299980977743958 1.0 0.9930054318474782 99.99857020628914 GOTERM_BP_FAT GO:0010927~cellular component assembly involved in morphogenesis 3 0.26785714285714285 0.6009253636524992 ACTC1, MYH11, OBSL1 751 36 13528 1.501109631602308 1.0 0.9964851617831675 99.99999237179881 GOTERM_BP_FAT GO:0048738~cardiac muscle tissue development 4 0.35714285714285715 0.6192335113012027 ACTC1, NDUFV2, MYH11, OBSL1 751 57 13528 1.264092321349312 1.0 0.9968880761174566 99.99999669973766 GOTERM_BP_FAT GO:0014706~striated muscle tissue development 7 0.625 0.6524451174731668 ALS2, ACTC1, NDUFV2, MYH11, OBSL1, CHRNA1, AFG3L2 751 119 13528 1.0596067987780997 1.0 0.9976265722674198 99.99999935223696 GOTERM_BP_FAT GO:0050808~synapse organization 4 0.35714285714285715 0.6650070900080198 ALS2, ACHE, CHRNA1, AFG3L2 751 61 13528 1.1812010215887014 1.0 0.9978974236495349 99.9999996641241 GOTERM_BP_FAT GO:0043062~extracellular structure organization 9 0.8035714285714285 0.6885903598767572 ALS2, ACHE, COL3A1, MYH11, COL1A2, LOX, CHRNA1, AFG3L2, COL5A2 751 163 13528 0.9946002467058236 1.0 0.9982846450084171 99.99999990868191 GOTERM_BP_FAT GO:0060537~muscle tissue development 7 0.625 0.6986110711229305 ALS2, ACTC1, NDUFV2, MYH11, OBSL1, CHRNA1, AFG3L2 751 125 13528 1.008745672436751 1.0 0.998391192596649 99.99999994905163 GOTERM_BP_FAT GO:0060538~skeletal muscle organ development 3 0.26785714285714285 0.8876143425869762 ALS2, CHRNA1, AFG3L2 751 66 13528 0.8187870717830771 1.0 0.9999257038842717 100.0 GOTERM_BP_FAT GO:0007519~skeletal muscle tissue development 3 0.26785714285714285 0.8876143425869762 ALS2, CHRNA1, AFG3L2 751 66 13528 0.8187870717830771 1.0 0.9999257038842717 100.0 Annotation Cluster 144 Enrichment Score: 0.359509769173179 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006888~ER to Golgi vesicle-mediated transport 4 0.35714285714285715 0.4140669122585251 SEC31A, HTT, BET1, LMAN1 751 42 13528 1.7155538646883521 1.0 0.991325357664011 99.99278584307227 GOTERM_BP_FAT GO:0048193~Golgi vesicle transport 9 0.8035714285714285 0.44160953398490843 AP1S1, SEC31A, NAPG, AP1B1, HTT, BET1, LMAN1, CUX1, STEAP2 751 131 13528 1.2375560321606813 1.0 0.992713549363094 99.9969441602858 SP_PIR_KEYWORDS er-golgi transport 6 0.5357142857142857 0.45641690726722595 KDELR2, MIA3, SEC31A, NAPG, BET1, LMAN1 1027 83 19235 1.3539259276639177 1.0 0.9145972319330502 99.98651399559013 Annotation Cluster 145 Enrichment Score: 0.3592298743009665 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043085~positive regulation of catalytic activity 35 3.125 0.1804338742830764 CALCR, ALS2, FTMT, ZAK, BTRC, TLR3, PMAIP1, BUD31, ADCYAP1, GALR1, BCL2, RAC1, TGM2, CHRNA7, HSPE1, CALCRL, PILRB, AIFM3, TAOK2, RALBP1, CDC23, MALT1, STRADB, STAT1, NLRP3, GNAL, GHRH, PSMC2, PSEN2, RELN, JAK2, HSPD1, NHEJ1, IL2, VLDLR 751 520 13528 1.2124347024480182 1.0 0.9824210592275261 97.12753006674627 GOTERM_BP_FAT GO:0042325~regulation of phosphorylation 30 2.6785714285714284 0.2884954967641892 ALS2, CSF2, CDK5R2, ZAK, BMPR2, TLR3, MCM7, BCL2, RAC1, CHRNA7, RAPGEF4, PILRB, EPO, IL3, NF2, TAOK2, RBL1, MALT1, CRIPAK, STRADB, INHA, CDC25C, VEGFC, PSEN2, ZFYVE28, PRKRIP1, JAK2, RELN, IL2, VLDLR 751 466 13528 1.1596555093923409 1.0 0.9855163864674777 99.76948072731659 GOTERM_BP_FAT GO:0044093~positive regulation of molecular function 36 3.214285714285714 0.35399745468270566 CALCR, ALS2, FTMT, ZAK, BTRC, TLR3, PMAIP1, BUD31, ADCYAP1, GALR1, BCL2, RAC1, TGM2, CHRNA7, HSPE1, CALCRL, PILRB, AIFM3, TAOK2, RALBP1, CDC23, MALT1, STRADB, STAT1, NLRP3, GNAL, GHRH, PSMC2, PSEN2, RELN, JAK2, HSPD1, NHEJ1, IL2, VLDLR, ADD1 751 586 13528 1.1066200697136468 1.0 0.9885510291936896 99.95884749851152 GOTERM_BP_FAT GO:0051174~regulation of phosphorus metabolic process 30 2.6785714285714284 0.36864279712073106 ALS2, CSF2, CDK5R2, ZAK, BMPR2, TLR3, MCM7, BCL2, RAC1, CHRNA7, RAPGEF4, PILRB, EPO, IL3, NF2, TAOK2, RBL1, MALT1, CRIPAK, STRADB, INHA, CDC25C, VEGFC, PSEN2, ZFYVE28, PRKRIP1, JAK2, RELN, IL2, VLDLR 751 485 13528 1.11422570593161 1.0 0.9884009925950422 99.97266516184536 GOTERM_BP_FAT GO:0019220~regulation of phosphate metabolic process 30 2.6785714285714284 0.36864279712073106 ALS2, CSF2, CDK5R2, ZAK, BMPR2, TLR3, MCM7, BCL2, RAC1, CHRNA7, RAPGEF4, PILRB, EPO, IL3, NF2, TAOK2, RBL1, MALT1, CRIPAK, STRADB, INHA, CDC25C, VEGFC, PSEN2, ZFYVE28, PRKRIP1, JAK2, RELN, IL2, VLDLR 751 485 13528 1.11422570593161 1.0 0.9884009925950422 99.97266516184536 GOTERM_BP_FAT GO:0032147~activation of protein kinase activity 8 0.7142857142857143 0.44660782062010324 ZAK, TAOK2, TLR3, MALT1, JAK2, STRADB, PILRB, IL2 751 114 13528 1.264092321349312 1.0 0.9927185065449012 99.99739707278457 GOTERM_BP_FAT GO:0051338~regulation of transferase activity 22 1.9642857142857142 0.5101762306022164 ALS2, FTMT, CDK5R2, ZAK, NF2, TAOK2, RBL1, TLR3, MALT1, CRIPAK, STRADB, CDC25C, PRKRIP1, PSEN2, ZFYVE28, RAC1, CHRNA7, JAK2, RELN, PILRB, VLDLR, IL2 751 372 13528 1.0653036095242185 1.0 0.994787570190324 99.9997048701831 GOTERM_BP_FAT GO:0043549~regulation of kinase activity 21 1.875 0.525677471550086 ALS2, CDK5R2, ZAK, NF2, TAOK2, RBL1, TLR3, MALT1, CRIPAK, STRADB, CDC25C, PRKRIP1, PSEN2, ZFYVE28, RAC1, CHRNA7, JAK2, RELN, PILRB, VLDLR, IL2 751 357 13528 1.0596067987780997 1.0 0.9950556109081272 99.99983371833108 GOTERM_BP_FAT GO:0051347~positive regulation of transferase activity 14 1.25 0.575320703232904 ALS2, FTMT, TAOK2, ZAK, TLR3, MALT1, STRADB, RAC1, RELN, JAK2, CHRNA7, PILRB, VLDLR, IL2 751 240 13528 1.0507767421216156 1.0 0.9958649164336344 99.9999768659155 GOTERM_BP_FAT GO:0033674~positive regulation of kinase activity 13 1.1607142857142858 0.6339667757348609 ALS2, TAOK2, ZAK, TLR3, MALT1, STRADB, RAC1, RELN, JAK2, CHRNA7, PILRB, VLDLR, IL2 751 231 13528 1.0137363745885715 1.0 0.9973114546948803 99.99999836775145 GOTERM_BP_FAT GO:0045859~regulation of protein kinase activity 19 1.6964285714285714 0.6400686391140477 ALS2, CDK5R2, ZAK, NF2, TAOK2, TLR3, MALT1, CRIPAK, STRADB, CDC25C, PSEN2, ZFYVE28, PRKRIP1, CHRNA7, RELN, JAK2, PILRB, VLDLR, IL2 751 345 13528 0.9920376695806558 1.0 0.9974377399070423 99.99999879070386 GOTERM_BP_FAT GO:0045860~positive regulation of protein kinase activity 12 1.0714285714285714 0.6982384989510609 ALS2, ZAK, TAOK2, TLR3, MALT1, CHRNA7, JAK2, RELN, STRADB, PILRB, VLDLR, IL2 751 223 13528 0.969326398882208 1.0 0.9984006175028993 99.99999994791621 Annotation Cluster 146 Enrichment Score: 0.35648468264154015 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0015377~cation:chloride symporter activity 3 0.26785714285714285 0.06951281566774131 SLC12A6, SLC12A9, SLC12A2 725 8 12983 6.7153448275862075 1.0 0.9626572788162446 67.29381891647253 GOTERM_MF_FAT GO:0015296~anion:cation symporter activity 4 0.35714285714285715 0.24809197222413215 SLC12A6, SLC12A9, SLC12A2, SLC1A1 725 31 12983 2.310656284760845 1.0 0.9897256156479338 98.80037886483264 INTERPRO IPR004841:Amino acid permease-associated region 3 0.26785714285714285 0.34446998334290113 SLC12A6, SLC12A9, SLC12A2 920 22 16659 2.4692193675889325 1.0 0.9992543307236836 99.89960488928914 GOTERM_MF_FAT GO:0008509~anion transmembrane transporter activity 9 0.8035714285714285 0.5798481384298549 SLC12A6, CLCN3, SLC12A9, SLC26A5, SLC12A2, GLRA3, CLIC2, SLC4A3, SLC1A1 725 147 12983 1.0963828289936663 1.0 0.9989895256875913 99.9998560511177 GOTERM_MF_FAT GO:0015294~solute:cation symporter activity 6 0.5357142857142857 0.6170052339569514 SLC32A1, SLC12A6, SLC23A1, SLC12A9, SLC12A2, SLC1A1 725 95 12983 1.131005444646098 1.0 0.9992331228670065 99.99996576977718 GOTERM_MF_FAT GO:0015370~solute:sodium symporter activity 3 0.26785714285714285 0.7945975958834225 SLC32A1, SLC23A1, SLC1A1 725 52 12983 1.033129973474801 1.0 0.9998115564943882 99.99999999782725 GOTERM_MF_FAT GO:0015293~symporter activity 6 0.5357142857142857 0.8861164851196469 SLC32A1, SLC12A6, SLC23A1, SLC12A9, SLC12A2, SLC1A1 725 137 12983 0.7842738484772213 1.0 0.9999679942215061 99.99999999999977 SP_PIR_KEYWORDS Symport 4 0.35714285714285715 0.9398366671745872 SLC12A6, SLC23A1, SLC12A2, SLC1A1 1027 111 19235 0.6749300420186496 1.0 0.9984906574891285 100.0 Annotation Cluster 147 Enrichment Score: 0.3543278627124668 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS metalloprotease 12 1.0714285714285714 0.18330884087713506 ERMP1, ADAMTS19, AQPEP, BRCC3, CNDP1, CNDP2, RNPEPL1, OSGEPL1, ADAM22, AFG3L2, PMPCB, DNPEP 1027 151 19235 1.4884218807431144 1.0 0.8096072682560278 94.81935410014015 GOTERM_MF_FAT GO:0008237~metallopeptidase activity 13 1.1607142857142858 0.3233327424762421 ERMP1, BRCC3, ADAM29, ADAMTS19, CNDP1, CNDP2, RNPEPL1, OSGEPL1, AFG3L2, DNPEP, AQPEP, ADAM22, PMPCB 725 183 12983 1.2721236103259845 1.0 0.9909336131176747 99.7662519792299 GOTERM_MF_FAT GO:0008233~peptidase activity 35 3.125 0.39958743147735315 ERMP1, ADAMTS19, CNDP1, CNDP2, TFR2, RNPEPL1, PEG10, KLKB1, SERPINE1, CASP8, OTUD7A, HGFAC, IHH, F11, CFLAR, UFSP2, BRCC3, ADAM29, SEC11C, UFD1L, CAPN8, MALT1, OSGEPL1, AFG3L2, CAPN2, DNPEP, CASP10, CAPN10, AQPEP, PSEN2, SPCS3, SERPINB2, RELN, ADAM22, PMPCB 725 574 12983 1.0919259882253995 1.0 0.9957480119613236 99.96341764470024 SP_PIR_KEYWORDS Protease 28 2.5 0.425889417740632 ERMP1, ADAMTS19, CNDP1, CNDP2, RNPEPL1, KLKB1, CASP8, OTUD7A, HGFAC, IHH, F11, BRCC3, UFSP2, SEC11C, CAPN8, MALT1, OSGEPL1, AFG3L2, CAPN2, DNPEP, CASP10, AQPEP, CAPN10, PSEN2, SPCS3, RELN, ADAM22, PMPCB 1027 484 19235 1.0835137244803528 1.0 0.9089282052525915 99.97002330446895 GOTERM_MF_FAT GO:0070011~peptidase activity, acting on L-amino acid peptides 32 2.857142857142857 0.5192755783895868 ERMP1, ADAMTS19, CNDP1, CNDP2, RNPEPL1, PEG10, KLKB1, SERPINE1, CASP8, OTUD7A, HGFAC, F11, CFLAR, UFSP2, ADAM29, BRCC3, SEC11C, UFD1L, CAPN8, MALT1, OSGEPL1, AFG3L2, CAPN2, DNPEP, CASP10, CAPN10, AQPEP, PSEN2, SERPINB2, RELN, ADAM22, PMPCB 725 549 12983 1.0437937315495258 1.0 0.9983624983493486 99.99883717485895 GOTERM_MF_FAT GO:0004175~endopeptidase activity 20 1.7857142857142856 0.7012940146659183 F11, CFLAR, ADAMTS19, ADAM29, CAPN8, OSGEPL1, MALT1, AFG3L2, CAPN2, CASP10, PEG10, CAPN10, KLKB1, SERPINE1, PSEN2, CASP8, SERPINB2, ADAM22, HGFAC, PMPCB 725 375 12983 0.9550712643678161 1.0 0.9993416801608723 99.99999927575405 UP_SEQ_FEATURE metal ion-binding site:Zinc; catalytic 5 0.4464285714285714 0.9008763060654188 ADAMTS19, AQPEP, BRCC3, RNPEPL1, AFG3L2 1024 123 19113 0.758741425304878 1.0 0.9999999999995551 100.0 Annotation Cluster 148 Enrichment Score: 0.35004929741700125 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Tyrosine-protein phosphatase 2 3 0.26785714285714285 0.13246406285625856 PTPRD, PTPRM, PTPRT 1024 12 19113 4.666259765625 1.0 0.9999795897633352 91.923268800267 UP_SEQ_FEATURE domain:Tyrosine-protein phosphatase 1 3 0.26785714285714285 0.13246406285625856 PTPRD, PTPRM, PTPRT 1024 12 19113 4.666259765625 1.0 0.9999795897633352 91.923268800267 INTERPRO IPR003962:Fibronectin, type III subdomain 4 0.35714285714285715 0.28860980080137566 EPHA4, PTPRD, MYOM1, EPHB4 920 34 16659 2.130306905370844 1.0 0.9986056329620477 99.6177869055314 UP_SEQ_FEATURE domain:Fibronectin type-III 2 8 0.7142857142857143 0.5484638750615509 EPHA4, PTPRD, PTPRM, SPEG, RIMBP3, PTPRT, MYOM1, EPHB4 1024 130 19113 1.1486177884615385 1.0 0.9999999057641966 99.99992317113252 UP_SEQ_FEATURE domain:Fibronectin type-III 1 8 0.7142857142857143 0.5566752661205165 EPHA4, PTPRD, PTPRM, SPEG, RIMBP3, PTPRT, MYOM1, EPHB4 1024 131 19113 1.139849713740458 1.0 0.9999999261756539 99.99994448793059 UP_SEQ_FEATURE domain:Fibronectin type-III 4 4 0.35714285714285715 0.6519233759101682 PTPRD, PTPRM, PTPRT, MYOM1 1024 62 19113 1.2041960685483872 1.0 0.9999999838388378 99.99999923390406 INTERPRO IPR008957:Fibronectin, type III-like fold 10 0.8928571428571428 0.6918414913417035 EPHA4, PTPRD, PTPRM, TRIM36, SPEG, TGM2, OBSL1, PTPRT, MYOM1, EPHB4 920 184 16659 0.9841091682419659 1.0 0.999993739733174 99.99999956082362 INTERPRO IPR003961:Fibronectin, type III 10 0.8928571428571428 0.7272926805934758 EPHA4, PTPRD, PTPRM, TRIM36, SPEG, RIMBP3, OBSL1, PTPRT, MYOM1, EPHB4 920 190 16659 0.9530320366132723 1.0 0.9999970442286898 99.99999994044111 SMART SM00060:FN3 10 0.8928571428571428 0.7519882627459135 EPHA4, PTPRD, PTPRM, TRIM36, SPEG, RIMBP3, OBSL1, PTPRT, MYOM1, EPHB4 513 190 9079 0.931466092130912 1.0 0.9992194768167297 99.9999989301796 UP_SEQ_FEATURE domain:Fibronectin type-III 3 4 0.35714285714285715 0.8281832032633714 PTPRD, PTPRM, PTPRT, MYOM1 1024 83 19113 0.8995199548192772 1.0 0.9999999999492708 99.99999999999714 Annotation Cluster 149 Enrichment Score: 0.33936127760148777 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010558~negative regulation of macromolecule biosynthetic process 36 3.214285714285714 0.20883356767755773 THAP7, GLIS3, HMGB2, TBX20, HAT1, NOSTRIN, SAP30, SUMO1, CDC45, CIR1, ITGAV, ATP8B1, ZNF496, PGGT1B, EGR1, CTBP1, NF2, PAIP2, SLA2, RBL1, FZD1, HDAC10, ZHX3, INHA, MXD4, DLX2, DLX1, EIF2AK1, PRDM6, NAB1, TGIF1, RFX3, LRCH4, CUX1, SMARCA2, SRP9 751 547 13528 1.1855198553056618 1.0 0.9833421462338807 98.46891005682915 GOTERM_BP_FAT GO:0009890~negative regulation of biosynthetic process 36 3.214285714285714 0.2984914424493967 THAP7, GLIS3, HMGB2, TBX20, HAT1, NOSTRIN, SAP30, SUMO1, CDC45, CIR1, ITGAV, ATP8B1, ZNF496, PGGT1B, EGR1, CTBP1, NF2, PAIP2, SLA2, RBL1, FZD1, HDAC10, ZHX3, INHA, MXD4, DLX2, DLX1, EIF2AK1, PRDM6, NAB1, TGIF1, RFX3, LRCH4, CUX1, SMARCA2, SRP9 751 573 13528 1.1317266332499076 1.0 0.9858402092526878 99.82090632639087 GOTERM_BP_FAT GO:0010605~negative regulation of macromolecule metabolic process 45 4.017857142857143 0.31250658907113754 THAP7, GLIS3, HMGB2, TBX20, HAT1, NOSTRIN, SRRT, SAP30, SUMO1, CDC45, CIR1, DGCR8, ITGAV, SERPINB10, ATP8B1, SERPINB12, ZNF496, PGGT1B, EGR1, CTBP1, NF2, PAIP2, SLA2, RBL1, FZD1, HDAC10, ZHX3, CDC23, INHA, MXD4, DLX2, DLX1, EIF2AK1, MAD2L1, PRDM6, PSMC2, NAB1, PSEN2, TGIF1, RFX3, LRCH4, CUX1, SMARCA2, SRP9, IL2 751 734 13528 1.1043585845575563 1.0 0.9873081130884785 99.87505630834505 GOTERM_BP_FAT GO:0031327~negative regulation of cellular biosynthetic process 34 3.0357142857142856 0.3904942598279991 THAP7, GLIS3, HMGB2, TBX20, HAT1, NOSTRIN, SAP30, SUMO1, CDC45, CIR1, ATP8B1, ZNF496, EGR1, CTBP1, NF2, PAIP2, SLA2, RBL1, FZD1, HDAC10, ZHX3, INHA, MXD4, DLX2, DLX1, EIF2AK1, PRDM6, NAB1, TGIF1, RFX3, LRCH4, CUX1, SMARCA2, SRP9 751 561 13528 1.0917160957107697 1.0 0.9901460485536145 99.98541866571178 GOTERM_BP_FAT GO:0016481~negative regulation of transcription 28 2.5 0.4003394213926152 GLIS3, THAP7, HMGB2, TBX20, HAT1, NOSTRIN, SAP30, SUMO1, CIR1, ATP8B1, ZNF496, EGR1, CTBP1, SLA2, RBL1, HDAC10, FZD1, ZHX3, MXD4, DLX2, DLX1, PRDM6, NAB1, TGIF1, RFX3, LRCH4, CUX1, SMARCA2 751 459 13528 1.0988514950291406 1.0 0.9905486245634462 99.98909512664707 GOTERM_BP_FAT GO:0051172~negative regulation of nitrogen compound metabolic process 31 2.767857142857143 0.4357993967019781 GLIS3, THAP7, HMGB2, TBX20, HAT1, NOSTRIN, COMT, SAP30, SUMO1, CDC45, CIR1, ATP8B1, ZNF496, EGR1, CTBP1, NF2, SLA2, RBL1, FZD1, HDAC10, ZHX3, MXD4, DLX2, DLX1, PRDM6, NAB1, TGIF1, RFX3, LRCH4, CUX1, SMARCA2 751 519 13528 1.0759398515530993 1.0 0.9926228858247936 99.99632433828943 GOTERM_BP_FAT GO:0010629~negative regulation of gene expression 30 2.6785714285714284 0.45466218284171706 GLIS3, THAP7, HMGB2, TBX20, HAT1, NOSTRIN, SAP30, SRRT, SUMO1, CIR1, DGCR8, ATP8B1, ZNF496, EGR1, CTBP1, SLA2, RBL1, HDAC10, FZD1, ZHX3, MXD4, DLX2, DLX1, PRDM6, NAB1, TGIF1, RFX3, LRCH4, CUX1, SMARCA2 751 504 13528 1.07222116543022 1.0 0.9928470523955819 99.99799616732507 GOTERM_BP_FAT GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 30 2.6785714285714284 0.49015380344619897 GLIS3, THAP7, HMGB2, TBX20, HAT1, NOSTRIN, SAP30, SUMO1, CDC45, CIR1, ATP8B1, ZNF496, EGR1, CTBP1, NF2, SLA2, RBL1, HDAC10, FZD1, ZHX3, MXD4, DLX2, DLX1, PRDM6, NAB1, TGIF1, RFX3, LRCH4, CUX1, SMARCA2 751 512 13528 1.0554677097203726 1.0 0.9939733739226864 99.99939683821133 GOTERM_MF_FAT GO:0016564~transcription repressor activity 19 1.6964285714285714 0.5137308128679403 THAP7, CTBP1, HMGB2, HTT, HIRA, HDAC10, NOSTRIN, FEV, MXD4, SAP30, CIR1, TSC22D4, SP3, NAB1, PRDM5, TGIF1, RFX3, LRCH4, CUX1 725 316 12983 1.0767219554779572 1.0 0.9984105048491094 99.99861077090331 GOTERM_BP_FAT GO:0045892~negative regulation of transcription, DNA-dependent 19 1.6964285714285714 0.691672887893159 EGR1, GLIS3, CTBP1, SLA2, TBX20, RBL1, HDAC10, HAT1, ZHX3, NOSTRIN, MXD4, SAP30, DLX2, DLX1, CIR1, TGIF1, CUX1, SMARCA2, ZNF496 751 356 13528 0.9613848202396805 1.0 0.9983337020041371 99.99999992353233 SP_PIR_KEYWORDS repressor 22 1.9642857142857142 0.7132010336558134 GLIS3, CTBP1, MAFB, RBL1, HDAC10, HIRA, ZHX3, MXD4, SAP30, CIR1, TSC22D4, BHLHA15, PRDM6, SP3, NAB1, PRDM5, TGIF1, RFX3, LIN54, CUX1, EWSR1, NFATC1 1027 435 19235 0.9472294037985874 1.0 0.9752867806071951 99.99999882404909 GOTERM_BP_FAT GO:0051253~negative regulation of RNA metabolic process 19 1.6964285714285714 0.7179664757140953 EGR1, GLIS3, CTBP1, SLA2, TBX20, RBL1, HDAC10, HAT1, ZHX3, NOSTRIN, MXD4, SAP30, DLX2, DLX1, CIR1, TGIF1, CUX1, SMARCA2, ZNF496 751 362 13528 0.9454502652080836 1.0 0.9985826908414819 99.99999998441034 GOTERM_BP_FAT GO:0000122~negative regulation of transcription from RNA polymerase II promoter 14 1.25 0.7201263072845256 EGR1, GLIS3, CTBP1, SLA2, RBL1, HDAC10, MXD4, SAP30, DLX2, DLX1, TGIF1, CUX1, SMARCA2, ZNF496 751 266 13528 0.9480692410119841 1.0 0.9985694246903726 99.99999998640835 Annotation Cluster 150 Enrichment Score: 0.3365379555369314 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:LisH 3 0.26785714285714285 0.4464234416176572 MAEA, WDR26, KIAA1468 1024 28 19113 1.9998256138392856 1.0 0.9999986597730182 99.9971662513075 INTERPRO IPR006594:LisH dimerisation motif 3 0.26785714285714285 0.46222647412805895 MAEA, WDR26, KIAA1468 920 28 16659 1.9401009316770186 1.0 0.9998703016454031 99.9960561258575 SMART SM00667:LisH 3 0.26785714285714285 0.47400653144694366 MAEA, WDR26, KIAA1468 513 28 9079 1.8961988304093567 1.0 0.9922043641542613 99.97875749263963 Annotation Cluster 151 Enrichment Score: 0.3311402491300854 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048729~tissue morphogenesis 14 1.25 0.19963475368992217 TWSG1, TBX6, ACTC1, NF2, HTT, BMPR2, GREM1, SHANK3, VEGFC, LAMA1, BCL2, CASP8, COL1A2, TGIF1 751 180 13528 1.4010356561621542 1.0 0.9843271086894949 98.11821967435876 GOTERM_BP_FAT GO:0002009~morphogenesis of an epithelium 8 0.7142857142857143 0.3275026705159328 LAMA1, VEGFC, HTT, BCL2, CASP8, TGIF1, GREM1, SHANK3 751 101 13528 1.4267972736021939 1.0 0.9877346464247443 99.91569874622998 GOTERM_BP_FAT GO:0016331~morphogenesis of embryonic epithelium 5 0.4464285714285714 0.40234939480136184 VEGFC, HTT, CASP8, TGIF1, SHANK3 751 58 13528 1.5528720326920427 1.0 0.9905470804522601 99.98972915722901 GOTERM_BP_FAT GO:0060562~epithelial tube morphogenesis 5 0.4464285714285714 0.5134682986243027 BCL2, CASP8, TGIF1, GREM1, SHANK3 751 67 13528 1.3442772820319178 1.0 0.9948985351240869 99.99973832511834 GOTERM_BP_FAT GO:0001838~embryonic epithelial tube formation 3 0.26785714285714285 0.6971702290839257 CASP8, TGIF1, SHANK3 751 43 13528 1.2567429473879788 1.0 0.9984103209067422 99.99999994452673 GOTERM_BP_FAT GO:0035148~tube lumen formation 3 0.26785714285714285 0.7092284094259473 CASP8, TGIF1, SHANK3 751 44 13528 1.2281806076746156 1.0 0.9985127412245044 99.999999973131 GOTERM_BP_FAT GO:0060429~epithelium development 12 1.0714285714285714 0.7199880977337765 LAMA1, VEGFC, HTT, DLX6, DLX5, BCL2, CASP8, FZD1, DHRS9, TGIF1, GREM1, SHANK3 751 227 13528 0.9522457574922131 1.0 0.9985831994581642 99.99999998628812 Annotation Cluster 152 Enrichment Score: 0.32683850727850805 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:Kelch 5 6 0.5357142857142857 0.2780176267387036 KBTBD2, LZTR1, KLHL22, KLHL23, KLHDC7B, KLHL3 1024 66 19113 1.6968217329545456 1.0 0.9999957926310487 99.68747626076687 UP_SEQ_FEATURE repeat:Kelch 4 6 0.5357142857142857 0.3202729274194579 KBTBD2, LZTR1, KLHL22, KLHL23, KLHDC7B, KLHL3 1024 70 19113 1.5998604910714287 1.0 0.9999980076056627 99.89257830197208 SP_PIR_KEYWORDS kelch repeat 6 0.5357142857142857 0.32836289539767644 KBTBD2, LZTR1, KLHL22, KLHL23, KLHDC7B, KLHL3 1027 71 19235 1.5827584788183824 1.0 0.8740694785791271 99.70290056597192 UP_SEQ_FEATURE repeat:Kelch 1 6 0.5357142857142857 0.330963950534086 KBTBD2, LZTR1, KLHL22, KLHL23, KLHDC7B, KLHL3 1024 71 19113 1.57732724471831 1.0 0.9999983501066504 99.9188709936631 UP_SEQ_FEATURE repeat:Kelch 2 6 0.5357142857142857 0.330963950534086 KBTBD2, LZTR1, KLHL22, KLHL23, KLHDC7B, KLHL3 1024 71 19113 1.57732724471831 1.0 0.9999983501066504 99.9188709936631 UP_SEQ_FEATURE repeat:Kelch 3 6 0.5357142857142857 0.330963950534086 KBTBD2, LZTR1, KLHL22, KLHL23, KLHDC7B, KLHL3 1024 71 19113 1.57732724471831 1.0 0.9999983501066504 99.9188709936631 INTERPRO IPR006652:Kelch repeat type 1 6 0.5357142857142857 0.3321609936642963 KBTBD2, LZTR1, KLHL22, KLHL23, KLHDC7B, KLHL3 920 69 16659 1.5745746691871454 1.0 0.9991477101501482 99.86392172758062 INTERPRO IPR015915:Kelch-type beta propeller 6 0.5357142857142857 0.3321609936642963 KBTBD2, LZTR1, KLHL22, KLHL23, KLHDC7B, KLHL3 920 69 16659 1.5745746691871454 1.0 0.9991477101501482 99.86392172758062 SMART SM00612:Kelch 6 0.5357142857142857 0.3491042721623082 KBTBD2, LZTR1, KLHL22, KLHL23, KLHDC7B, KLHL3 513 69 9079 1.538943978303246 1.0 0.9845689079595386 99.64907712657781 PIR_SUPERFAMILY PIRSF037037:Kelch-like_protein_gigaxonin 4 0.35714285714285715 0.37444437094447364 KBTBD2, KLHL22, KLHL23, KLHL3 395 41 7396 1.8267366471133064 1.0 0.9999988086474308 99.84804763959755 INTERPRO IPR017096:Kelch-like protein, gigaxonin 4 0.35714285714285715 0.3958137320787338 KBTBD2, KLHL22, KLHL23, KLHL3 920 41 16659 1.7665959703075294 1.0 0.9996546328381818 99.9735363896882 UP_SEQ_FEATURE repeat:Kelch 6 4 0.35714285714285715 0.5319513639440402 LZTR1, KLHL22, KLHL23, KLHL3 1024 52 19113 1.4357722355769231 1.0 0.9999998815786241 99.99985487842403 INTERPRO IPR011705:BTB/Kelch-associated 4 0.35714285714285715 0.603621833777279 KBTBD2, KLHL22, KLHL23, KLHL3 920 56 16659 1.2934006211180125 1.0 0.9999742093992091 99.99997308324421 INTERPRO IPR013089:Kelch related 5 0.4464285714285714 0.6405735614621229 KBTBD2, KLHL22, KLHL23, KLHDC7B, KLHL3 920 79 16659 1.146051183269125 1.0 0.9999849402481427 99.99999456435911 INTERPRO IPR011333:BTB/POZ fold 9 0.8035714285714285 0.7875286552065397 KBTBD2, LZTR1, KLHL22, KCTD18, KLHL23, KCTD13, KCNV2, KLHL3, KCNG2 920 181 16659 0.9003783329329811 1.0 0.9999991898063452 99.99999999899326 INTERPRO IPR000210:BTB/POZ-like 8 0.7142857142857143 0.870314804757414 KBTBD2, LZTR1, KLHL22, KCTD18, KLHL23, KCTD13, KLHL3, KCNG2 920 179 16659 0.8092786009230022 1.0 0.999999965841861 99.99999999999969 UP_SEQ_FEATURE domain:BTB 6 0.5357142857142857 0.8827949214397127 KBTBD2, KLHL22, KCTD18, KLHL23, KCTD13, KLHL3 1024 142 19113 0.788663622359155 1.0 0.9999999999985921 100.0 SMART SM00225:BTB 8 0.7142857142857143 0.8852332213995022 KBTBD2, LZTR1, KLHL22, KCTD18, KLHL23, KCTD13, KLHL3, KCNG2 513 179 9079 0.7909656201335119 1.0 0.9999127443182856 99.99999999995791 INTERPRO IPR013069:BTB/POZ 5 0.4464285714285714 0.9250877200382814 KBTBD2, LZTR1, KLHL22, KLHL23, KLHL3 920 127 16659 0.7128979801437864 1.0 0.9999999984000888 100.0 Annotation Cluster 153 Enrichment Score: 0.32675290337717505 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044448~cell cortex part 7 0.625 0.31608300217211294 SEPT5, ACTB, PPP1R9A, MAEA, ANLN, FABP2, SEPT7 713 83 12782 1.5119214586255258 1.0 0.921810615812455 99.56794537348857 GOTERM_BP_FAT GO:0000910~cytokinesis 4 0.35714285714285715 0.39893272355193987 SEPT5, AHCTF1, ANLN, SEPT7 751 41 13528 1.7573966418758729 1.0 0.9904918093893557 99.98862961100954 GOTERM_CC_FAT GO:0005938~cell cortex 7 0.625 0.8299281323407988 SEPT5, ACTB, PPP1R9A, MAEA, ANLN, FABP2, SEPT7 713 146 12782 0.8595169936021826 1.0 0.9922623206412701 99.99999999905663 Annotation Cluster 154 Enrichment Score: 0.3220013180475495 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS glycoprotein 248 22.142857142857142 0.10957099224665849 GLB1L, SCN3A, MEGF10, CDH20, FAM171B, TRAK2, PRRT2, PLOD3, SERPINE1, CCBE1, CHRNA7, NPSR1, CHRNA1, MUC12, F11, SLC12A6, TMEFF2, WNT10A, SLC12A9, PTPRM, ABCB11, PLD5, SCN2A, F8, PTPRT, C1ORF101, COLEC12, PTPRN, PDCD1LG2, LPCAT4, VEGFC, RYR3, MC2R, TFPI, CD226, OR13G1, TPST2, ERMP1, SCN1A, CLCN3, CRELD2, OR2T2, OR2T1, DNAH14, OR2T4, TMX3, OR2T3, NPY6R, EPHB4, GPR141, SLC32A1, TMEM129, KLKB1, OR2T5, OR2T6, OR2T8, OR2C3, GPR155, PCDH10, TRPC7, MSTN, EMILIN2, EMILIN3, LAMA1, EPHA4, SEMA6A, SFRP4, STEAP4, GLRA3, APCDD1, SLC23A1, TNFRSF11A, P4HA2, XYLT1, SCRG1, MAPT, TICAM2, MC5R, IHH, KIAA1324L, PGAP1, OR2W5, OR2W3, OR2AE1, LRPAP1, SLC26A5, AQPEP, CHSY3, SERPINB5, SERPINB2, CYBRD1, SIL1, C4ORF29, SUSD4, SGCE, SERPINB4, SERPINB3, CSF2, OR6F1, EPDR1, SLC39A10, TFR2, COL3A1, PCOLCE, NETO1, OR2G3, OR2G2, GPM6A, OR2G6, DISP1, LRRTM2, HGFAC, WNT8A, MOGAT3, IL3, CNST, FZD1, RTN4R, KCNV2, FZD7, CDH19, KREMEN1, ARSA, MC4R, ABCC1, SERPIND1, LRP2, IL2, GFRA3, ABCC6, VLDLR, QRFPR, OR2AK2, CNDP1, ZAN, TLR3, TLR5, AGXT, AZGP1, SEZ6L2, GPR89B, GALR1, RPN2, LOX, WNT6, SPON2, TFPI2, OR14C36, HHIPL2, PLXNB2, IL21, PKD2L2, C2ORF69, CHPF, UPK3BL, COL1A2, RELN, SLC40A1, OR2L8, TWSG1, GAL3ST4, OR2L5, ACHE, FGFR3, PANX2, TMEM63A, BMPR2, TMEM219, SLC38A11, GREM1, OR2L3, OR2L13, G6PC2, OR2L2, AZGP1P1, MIA3, ITGAV, OR2T33, SCN9A, LMTK2, OR2T35, MFAP3L, OR2T34, OR2M7, NOMO3, ADAM29, ABCB1, OR2M2, OR2M3, OR2M4, OR2M5, ABCB4, OR14A16, GPR35, P2RX6, OR2T29, ITGA6, OR2T27, CD274, ECSCR, SPCS3, ADAM22, HMSD, GPC2, DGCR2, OR2T10, OR2T11, HPSE, OR2T12, VN1R5, EMID1, AOAH, DSEL, GALNTL6, CLUL1, SCN7A, CALCRL, LBP, GPC1, SLC1A1, PILRB, PILRA, HEPACAM2, INHA, LEFTY1, PIGN, BPI, MUC3A, CHRM5, OR14I1, GALNT3, CALCR, FKBP9, ADAMTS19, LMF2, SPOCK1, SCARF2, TMED7, GP1BB, NPTX2, LEFTY2, EPO, PTPRD, NF2, SLC12A2, OR2B11, OR11L1, COL5A2, BMPER, SP9, MUC17 1027 4318 19235 1.075699061874096 1.0 0.7398990888997288 81.66850131372323 UP_SEQ_FEATURE glycosylation site:N-linked (GlcNAc...) 235 20.982142857142858 0.1667329349245238 GLB1L, SCN3A, MEGF10, CDH20, FAM171B, PRRT2, PLOD3, SERPINE1, CCBE1, CHRNA7, NPSR1, CHRNA1, MUC12, F11, SLC12A6, TMEFF2, WNT10A, SLC12A9, PTPRM, ABCB11, PLD5, SCN2A, F8, PTPRT, COLEC12, C1ORF101, PTPRN, PDCD1LG2, LPCAT4, VEGFC, RYR3, MC2R, TFPI, CD226, OR13G1, TPST2, ERMP1, SCN1A, CLCN3, CRELD2, OR2T2, OR2T1, DNAH14, OR2T4, TMX3, OR2T3, NPY6R, EPHB4, GPR141, SLC32A1, TMEM129, KLKB1, OR2T5, OR2T6, OR2T8, OR2C3, GPR155, PCDH10, TRPC7, MSTN, EMILIN2, EMILIN3, LAMA1, EPHA4, SEMA6A, SFRP4, STEAP4, GLRA3, APCDD1, SLC23A1, TNFRSF11A, P4HA2, XYLT1, SCRG1, TICAM2, MC5R, IHH, KIAA1324L, PGAP1, OR2W5, OR2W3, OR2AE1, LRPAP1, SLC26A5, AQPEP, CHSY3, SERPINB5, SERPINB2, CYBRD1, SIL1, C4ORF29, SUSD4, SGCE, CSF2, OR6F1, EPDR1, SLC39A10, TFR2, PCOLCE, NETO1, OR2G3, OR2G2, GPM6A, OR2G6, DISP1, LRRTM2, HGFAC, WNT8A, MOGAT3, IL3, CNST, FZD1, RTN4R, KCNV2, FZD7, CDH19, KREMEN1, ARSA, MC4R, ABCC1, SERPIND1, LRP2, GFRA3, ABCC6, VLDLR, QRFPR, OR2AK2, CNDP1, ZAN, TLR3, TLR5, AZGP1, SEZ6L2, GPR89B, GALR1, RPN2, LOX, WNT6, TFPI2, OR14C36, HHIPL2, PLXNB2, IL21, PKD2L2, C2ORF69, CHPF, UPK3BL, COL1A2, RELN, SLC40A1, OR2L8, TWSG1, GAL3ST4, OR2L5, ACHE, FGFR3, PANX2, TMEM63A, BMPR2, TMEM219, SLC38A11, GREM1, OR2L3, OR2L13, G6PC2, OR2L2, AZGP1P1, MIA3, ITGAV, OR2T33, SCN9A, LMTK2, OR2T35, MFAP3L, OR2T34, OR2M7, NOMO3, ADAM29, ABCB1, OR2M2, OR2M3, OR2M4, OR2M5, ABCB4, OR14A16, GPR35, P2RX6, OR2T29, ITGA6, OR2T27, CD274, SPCS3, ADAM22, HMSD, DGCR2, OR2T10, OR2T11, HPSE, OR2T12, VN1R5, EMID1, AOAH, DSEL, GALNTL6, CLUL1, SCN7A, CALCRL, LBP, GPC1, SLC1A1, PILRB, PILRA, HEPACAM2, INHA, LEFTY1, PIGN, BPI, CHRM5, OR14I1, CALCR, GALNT3, FKBP9, ADAMTS19, LMF2, SCARF2, TMED7, GP1BB, NPTX2, LEFTY2, EPO, PTPRD, SLC12A2, OR2B11, OR11L1, COL5A2, BMPER, SP9, MUC17 1024 4129 19113 1.062311499076653 1.0 0.9999923676127783 96.0436055557022 GOTERM_CC_FAT GO:0005615~extracellular space 40 3.571428571428571 0.4833999349077145 CSF2, TWSG1, INSL4, COL3A1, TAC1, IL33, VGF, GREM1, GPC2, SCRG1, KLKB1, LEFTY2, LOX, LBP, HGFAC, GPC1, EPO, IHH, F11, IL3, F8, MSTN, INHA, IL21, LEFTY1, GRP, VEGFC, SERPINB5, GHRH, SFRP4, COL1A2, ARSA, SERPINB2, TFPI, RELN, KDSR, HSPD1, LRP2, VLDLR, IL2 713 685 12782 1.0468361298512505 1.0 0.9588342506695418 99.99224826347117 GOTERM_CC_FAT GO:0044421~extracellular region part 55 4.910714285714286 0.48434909051403857 INSL4, VGF, GPC2, SCRG1, EMID1, LBP, LOX, WNT6, SPON2, TFPI2, GPC1, IHH, F11, TFIP11, WNT10A, F8, INHA, IL21, LEFTY1, GRP, VEGFC, GHRH, SERPINB5, COL1A2, SERPINB2, TFPI, RELN, KDSR, ALDOA, CSF2, TWSG1, ACHE, ADAMTS19, COL3A1, TAC1, SPOCK1, IL33, GREM1, KLKB1, LEFTY2, HGFAC, WNT8A, EPO, IL3, MSTN, EMILIN2, COL5A2, EMILIN3, LAMA1, SFRP4, ARSA, HSPD1, LRP2, VLDLR, IL2 713 960 12782 1.0270716456287985 1.0 0.9578852608342099 99.99244988105964 SP_PIR_KEYWORDS Secreted 86 7.678571428571429 0.7342029506686559 HMSD, INSL4, GLB1L, CNDP1, LRRC17, VGF, INSL6, AZGP1, GPC2, RLN1, RESP18, SCRG1, XYLT1, HPSE, EMID1, CCBE1, SERPINE1, RLN2, CLUL1, LOX, LBP, SPON2, WNT6, GPC1, TFPI2, PILRA, IHH, F11, TMEFF2, HHIPL2, WNT10A, F8, INHA, IL21, PDCD1LG2, LEFTY1, GRP, C2ORF66, VEGFC, BPI, MUC3A, C2ORF69, SERPINB5, GHRH, COL1A2, SERPINB2, TFPI, C4ORF29, RELN, CSF2, TWSG1, ACHE, ADAMTS19, CRELD2, EPDR1, ACP6, COL3A1, TAC1, SPOCK1, IL33, TMEM155, C2ORF88, CNPY4, GREM1, PCOLCE, NETO1, ADCYAP1, AZGP1P1, NPTX2, KLKB1, LEFTY2, SCG5, HGFAC, WNT8A, EPO, IL3, MSTN, EMILIN2, EMILIN3, COL5A2, LAMA1, BMPER, ZG16, SFRP4, ADM2, MUC17, IL2 1027 1689 19235 0.9536533719819464 1.0 0.9785910176633336 99.99999961313 SP_PIR_KEYWORDS signal 158 14.107142857142858 0.9269018619183448 GLB1L, CNDP1, ZAN, TLR3, TLR5, MEGF10, AZGP1, SEZ6L2, CDH20, FAM171B, RLN1, PLOD3, RLN2, SERPINE1, CCBE1, CHRNA7, RPN2, LOX, WNT6, SPON2, CHRNA1, TFPI2, MUC12, F11, TMEFF2, HHIPL2, WNT10A, PTPRM, PLXNB2, F8, C1ORF101, PTPRT, PTPRN, IL21, PDCD1LG2, C2ORF66, VEGFC, C2ORF69, UPK3BL, COL1A2, TFPI, RELN, KDSR, CD226, TWSG1, ACHE, FGFR3, CRELD2, ACP6, TMX3, BMPR2, CNPY4, LMAN1, GREM1, EPHB4, CASD1, ADCYAP1, AZGP1P1, TMEM129, MIA3, KLKB1, ITGAV, LMTK2, MFAP3L, ADAM29, NOMO3, PCDH10, MSTN, EMILIN2, EMILIN3, LAMA1, EPHA4, SEMA6A, ITGA6, ECSCR, CD274, SFRP4, ADM2, ADAM22, INSL4, HMSD, GLRA3, LRRC17, INSL6, VGF, APCDD1, DGCR2, GPC2, TNFRSF11A, P4HA2, HPSE, SCRG1, RESP18, AOAH, EMID1, DSEL, CLUL1, TICAM2, CALCRL, LBP, GPC1, PILRB, IHH, PILRA, KIAA1324L, DHRS9, HEPACAM2, INHA, LRPAP1, LEFTY1, GRP, BPI, MUC3A, GHRH, SERPINB2, SIL1, C4ORF29, SUSD4, CALCR, CSF2, FKBP9, ADAMTS19, EPDR1, SLC39A10, COL3A1, TAC1, SPOCK1, C2ORF88, TMEM155, PCOLCE, NETO1, SCARF2, TMED7, NPTX2, GP1BB, LRRTM2, LEFTY2, SCG5, HGFAC, WNT8A, EPO, IL3, PTPRD, FZD1, RTN4R, COL5A2, FZD7, BMPER, ZG16, SDF2L1, CDH19, KREMEN1, VSTM2L, ARSA, SERPIND1, LRP2, MUC17, IL2, GFRA3, VLDLR 1027 3250 19235 0.9105325443786982 1.0 0.9976915742719463 100.0 UP_SEQ_FEATURE signal peptide 158 14.107142857142858 0.9337067511036696 GLB1L, CNDP1, ZAN, TLR3, TLR5, MEGF10, AZGP1, SEZ6L2, CDH20, FAM171B, RLN1, PLOD3, RLN2, SERPINE1, CCBE1, CHRNA7, RPN2, LOX, WNT6, SPON2, CHRNA1, TFPI2, MUC12, F11, TMEFF2, HHIPL2, WNT10A, PTPRM, PLXNB2, F8, C1ORF101, PTPRT, PTPRN, IL21, PDCD1LG2, C2ORF66, VEGFC, C2ORF69, UPK3BL, COL1A2, TFPI, RELN, KDSR, CD226, TWSG1, ACHE, FGFR3, CRELD2, ACP6, TMX3, BMPR2, CNPY4, LMAN1, GREM1, EPHB4, CASD1, ADCYAP1, AZGP1P1, TMEM129, MIA3, KLKB1, ITGAV, LMTK2, MFAP3L, ADAM29, NOMO3, PCDH10, MSTN, EMILIN2, EMILIN3, LAMA1, EPHA4, SEMA6A, ITGA6, ECSCR, CD274, SFRP4, ADM2, ADAM22, INSL4, HMSD, GLRA3, LRRC17, INSL6, VGF, APCDD1, DGCR2, GPC2, TNFRSF11A, P4HA2, HPSE, SCRG1, RESP18, AOAH, EMID1, DSEL, CLUL1, TICAM2, CALCRL, LBP, GPC1, PILRB, IHH, PILRA, KIAA1324L, DHRS9, HEPACAM2, INHA, LRPAP1, LEFTY1, GRP, BPI, MUC3A, GHRH, SERPINB2, SIL1, C4ORF29, SUSD4, CALCR, CSF2, FKBP9, ADAMTS19, EPDR1, SLC39A10, COL3A1, TAC1, SPOCK1, C2ORF88, TMEM155, PCOLCE, NETO1, SCARF2, TMED7, NPTX2, GP1BB, LRRTM2, LEFTY2, SCG5, HGFAC, WNT8A, EPO, IL3, PTPRD, FZD1, RTN4R, COL5A2, FZD7, BMPER, ZG16, SDF2L1, CDH19, KREMEN1, VSTM2L, ARSA, SERPIND1, LRP2, MUC17, IL2, GFRA3, VLDLR 1024 3250 19113 0.9074080528846153 1.0 0.9999999999999876 100.0 GOTERM_CC_FAT GO:0005576~extracellular region 95 8.482142857142858 0.976668117878894 HMSD, INSL4, GLB1L, CNDP1, VGF, INSL6, AZGP1, GPC2, RLN1, RESP18, SCRG1, XYLT1, HPSE, EMID1, CCBE1, SERPINE1, RLN2, CLUL1, LOX, LBP, SPON2, WNT6, GPC1, TFPI2, PILRA, IHH, TFIP11, F11, TMEFF2, HHIPL2, WNT10A, F8, INHA, IL21, PDCD1LG2, LEFTY1, GRP, C2ORF66, VEGFC, BPI, MUC3A, C2ORF69, SERPINB5, GHRH, COL1A2, TFPI, SERPINB2, TUBA4A, KDSR, C4ORF29, RELN, ALDOA, CSF2, TWSG1, ACHE, CRELD2, ADAMTS19, EPDR1, ACP6, COL3A1, TAC1, SPOCK1, IL33, TMEM155, C2ORF88, CNPY4, GREM1, PCOLCE, NETO1, ADCYAP1, AZGP1P1, NPTX2, KLKB1, LEFTY2, SCG5, HGFAC, WNT8A, EPO, IL3, MSTN, EMILIN2, EMILIN3, COL5A2, LAMA1, BMPER, ZG16, SFRP4, ARSA, ADM2, ADAM22, SERPIND1, HSPD1, LRP2, MUC17, IL2, VLDLR 713 2010 12782 0.8472992680356981 1.0 0.9999049040673612 100.0 Annotation Cluster 155 Enrichment Score: 0.3219229891882396 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007249~I-kappaB kinase/NF-kappaB cascade 7 0.625 0.13519760116141566 TMED7, TICAM2, TLR3, MALT1, TLR5, TRIP6, TNIP2, STAT1 751 63 13528 2.0014795088030772 1.0 0.9764695483947345 92.50905511229341 INTERPRO IPR000157:Toll-Interleukin receptor 3 0.26785714285714285 0.3648196181659567 TMED7, TICAM2, TLR3, TLR5 920 23 16659 2.361862003780718 1.0 0.9994178320935416 99.94004537704008 UP_SEQ_FEATURE domain:TIR 3 0.26785714285714285 0.37050073171490644 TMED7, TICAM2, TLR3, TLR5 1024 24 19113 2.3331298828125 1.0 0.9999980395848098 99.97241066800787 SMART SM00255:TIR 3 0.26785714285714285 0.37526510907257393 TMED7, TICAM2, TLR3, TLR5 513 23 9079 2.308415967454869 1.0 0.9859511242377708 99.79549665753582 GOTERM_BP_FAT GO:0045087~innate immune response 8 0.7142857142857143 0.649517985717939 TMED7, TMEM173, TICAM2, SAMHD1, TLR3, COLEC12, MALT1, TLR5, LBP 751 138 13528 1.0442501785059535 1.0 0.9975712775562611 99.99999924768616 SP_PIR_KEYWORDS inflammatory response 4 0.35714285714285715 0.7857345239551055 TMED7, KLKB1, TICAM2, TLR3, TLR5 1027 77 19235 0.972951099533378 1.0 0.9838427594915465 99.9999999834321 SP_PIR_KEYWORDS innate immunity 4 0.35714285714285715 0.7930178566670998 TMEM173, SAMHD1, TLR3, TLR5 1027 78 19235 0.9604773674880782 1.0 0.9840518451554557 99.99999999000687 SP_PIR_KEYWORDS immune response 8 0.7142857142857143 0.9578371453446792 EXO1, TMED7, TMEM173, TICAM2, SAMHD1, TLR3, TLR5, SPON2, IL2 1027 224 19235 0.6689038809291974 1.0 0.9992299330005515 100.0 Annotation Cluster 156 Enrichment Score: 0.3202139890510672 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0042802~identical protein binding 40 3.571428571428571 0.3077804240083529 ALDOA, ALS2, CLCN3, ACHE, FGFR3, ZAK, HPS4, CLDN5, NFS1, ASNS, LMAN1, CLDN12, AGXT, CLDN15, NDE1, BHLHA15, HAND2, BCL2, MAPT, CASP8, CHRNA7, AK3, CIDEA, TBX1, ZNF3, CASP10, EIF2AK1, MAD2L1, PRDM6, SPAG4, COL1A2, TXNRD2, CRYBA2, KCTD13, PARP1, TRIP6, HPGD, SCAND1, NHEJ1, ADD1 725 640 12983 1.1192241379310346 1.0 0.990814359768371 99.66746812592098 GOTERM_MF_FAT GO:0042803~protein homodimerization activity 20 1.7857142857142856 0.513986454701385 ALS2, CLCN3, ACHE, HPS4, NFS1, CIDEA, ASNS, TBX1, AGXT, EIF2AK1, MAD2L1, BHLHA15, HAND2, PRDM6, BCL2, TXNRD2, CHRNA7, CRYBA2, HPGD, ADD1 725 334 12983 1.0723105513111708 1.0 0.9983103477014563 99.99862205706117 GOTERM_MF_FAT GO:0046983~protein dimerization activity 29 2.5892857142857144 0.6920944478375743 ALS2, CLCN3, ACHE, CNDP1, VAPA, CNDP2, POLR2J, HPS4, NFS1, ASNS, AGXT, ATF2, HAND2, BHLHA15, BCL2, CHRNA7, CIDEA, TBX1, INHA, POLR2J2, POLR2J3, P2RX6, MAD2L1, EIF2AK1, ZBED4, PRDM6, TXNRD2, CRYBA2, HPGD, ADD1 725 542 12983 0.9581549815498155 1.0 0.9993891600066207 99.99999884058921 Annotation Cluster 157 Enrichment Score: 0.3198793981939479 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:EGF-like 7 0.625 0.22106731385851883 TMEFF2, MUC3A, ADAM29, ZAN, ADAM22, MUC17, MUC12 1024 76 19113 1.7191483347039471 1.0 0.999994870090342 98.80118303632813 INTERPRO IPR013032:EGF-like region, conserved site 20 1.7857142857142856 0.2663891610846454 TMEFF2, ADAM29, CRELD2, ZAN, PCDH10, EPHB4, MEGF10, SCARF2, LAMA1, MUC3A, TNFRSF11A, FLJ44313, CCBE1, RELN, ADAM22, LRP2, HGFAC, MUC17, MUC12, VLDLR 920 293 16659 1.2360142454370084 1.0 0.9988625248216937 99.36806016635329 INTERPRO IPR006210:EGF-like 13 1.1607142857142858 0.43156065892964884 TMEFF2, CRELD2, ZAN, MEGF10, SCARF2, MUC3A, CCBE1, RELN, ADAM22, LRP2, HGFAC, MUC17, VLDLR 920 201 16659 1.1711388708630759 1.0 0.9997596180860162 99.99023544670337 SP_PIR_KEYWORDS egf-like domain 14 1.25 0.45565761226545776 TMEFF2, CRELD2, ADAM29, ZAN, MEGF10, SCARF2, MUC3A, CCBE1, RELN, ADAM22, LRP2, HGFAC, MUC12, VLDLR 1027 230 19235 1.140044875322806 1.0 0.9156398872371853 99.98623597457998 SMART SM00181:EGF 13 1.1607142857142858 0.4621973105915001 TMEFF2, CRELD2, ZAN, MEGF10, SCARF2, MUC3A, CCBE1, RELN, ADAM22, LRP2, HGFAC, MUC17, VLDLR 513 201 9079 1.144637436598683 1.0 0.9919359047265079 99.97154663817133 INTERPRO IPR000742:EGF-like, type 3 12 1.0714285714285714 0.5070182304306787 TMEFF2, MUC3A, CRELD2, CCBE1, ZAN, RELN, LRP2, HGFAC, MEGF10, MUC17, SCARF2, VLDLR 920 194 16659 1.120058269834155 1.0 0.999923341486821 99.99904831245557 UP_SEQ_FEATURE domain:EGF-like 3 5 0.4464285714285714 0.5751369613470116 RELN, LRP2, MEGF10, SCARF2, VLDLR 1024 75 19113 1.2443359375 1.0 0.99999994010257 99.99997386156268 UP_SEQ_FEATURE domain:EGF-like 1 7 0.625 0.6261086387179805 CRELD2, RELN, LRP2, HGFAC, MEGF10, SCARF2, VLDLR 1024 120 19113 1.0887939453125 1.0 0.9999999652970677 99.99999728068076 UP_SEQ_FEATURE domain:EGF-like 2 5 0.4464285714285714 0.6998896581201263 RELN, LRP2, HGFAC, MEGF10, SCARF2 1024 88 19113 1.060513583096591 1.0 0.999999995404755 99.99999994453248 INTERPRO IPR006209:EGF 5 0.4464285714285714 0.9250877200382814 TMEFF2, ZAN, LRP2, HGFAC, VLDLR 920 127 16659 0.7128979801437864 1.0 0.9999999984000888 100.0 Annotation Cluster 158 Enrichment Score: 0.31918869939350913 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010876~lipid localization 11 0.9821428571428571 0.372241311898593 CPT1B, GULP1, ATP9B, CHKB, ATP8B1, VPS4B, CIDEA, SLC27A6, FABP2, LBP, CROT, VLDLR 751 157 13528 1.2620794354872908 1.0 0.9886754943268797 99.9753152933287 GOTERM_BP_FAT GO:0006869~lipid transport 10 0.8928571428571428 0.4129851967535603 CPT1B, GULP1, ATP9B, CHKB, ATP8B1, VPS4B, SLC27A6, FABP2, LBP, CROT, VLDLR 751 145 13528 1.2422976261536343 1.0 0.9914480147542912 99.99254450076718 GOTERM_BP_FAT GO:0015718~monocarboxylic acid transport 4 0.35714285714285715 0.5294763032623697 CPT1B, CHKB, ATP8B1, FABP2, CROT 751 50 13528 1.4410652463382159 1.0 0.9952003961220742 99.99985594138239 SP_PIR_KEYWORDS lipid transport 4 0.35714285714285715 0.6495904319896544 GULP1, SLC27A6, LBP, VLDLR 1027 62 19235 1.208342494581776 1.0 0.9644818506513657 99.99997801085205 Annotation Cluster 159 Enrichment Score: 0.314451817757265 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0035239~tube morphogenesis 10 0.8928571428571428 0.27194674888812903 BBS5, BBS7, HAND2, BCL2, TBX20, CASP8, TGIF1, GREM1, SHANK3, IHH 751 127 13528 1.4183713054509997 1.0 0.9839963203626834 99.65257743421132 GOTERM_BP_FAT GO:0001763~morphogenesis of a branching structure 5 0.4464285714285714 0.5928721788831601 DLX2, BCL2, TBX20, GREM1, IHH 751 74 13528 1.217115917515385 1.0 0.9962653992303526 99.9999891051315 GOTERM_BP_FAT GO:0048754~branching morphogenesis of a tube 4 0.35714285714285715 0.7066422567355238 BCL2, TBX20, GREM1, IHH 751 65 13528 1.1085117279524737 1.0 0.9984986171237576 99.99999996853262 Annotation Cluster 160 Enrichment Score: 0.30951330481978556 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051493~regulation of cytoskeleton organization 11 0.9821428571428571 0.22238623125107915 ARPC1A, ARPC1B, PLK4, NF2, CEP76, MAPT, RAC1, TAC1, RANBP1, CRIPAK, ADD1 751 136 13528 1.4569593483198873 1.0 0.9832028602116055 98.87507460716022 GOTERM_BP_FAT GO:0033043~regulation of organelle organization 16 1.4285714285714286 0.22404538951736758 NF2, CEP76, TAC1, CDC23, CRIPAK, CDC25C, ARPC1A, ARPC1B, PLK4, PSMG2, MAD2L1, MAPT, RAC1, TLK1, RANBP1, ADD1 751 217 13528 1.3281707339522728 1.0 0.9825738361816492 98.91713574324373 GOTERM_BP_FAT GO:0051495~positive regulation of cytoskeleton organization 5 0.4464285714285714 0.2379256132539181 PLK4, NF2, MAPT, RAC1, TAC1 751 45 13528 2.0014795088030772 1.0 0.9819243145682289 99.21527124200841 GOTERM_BP_FAT GO:0010638~positive regulation of organelle organization 6 0.5357142857142857 0.49059753828727765 PLK4, NF2, MAPT, RAC1, TAC1, RANBP1 751 83 13528 1.302167391269472 1.0 0.9939285171970772 99.99940613550633 GOTERM_BP_FAT GO:0032271~regulation of protein polymerization 5 0.4464285714285714 0.525258107205379 ARPC1A, ARPC1B, MAPT, RAC1, ADD1 751 68 13528 1.3245084984726248 1.0 0.9950921252743453 99.99983107582085 GOTERM_BP_FAT GO:0032956~regulation of actin cytoskeleton organization 6 0.5357142857142857 0.5531663816345158 ARPC1A, ARPC1B, NF2, RAC1, TAC1, ADD1 751 89 13528 1.214380825565912 1.0 0.9953056762220782 99.99994268536832 GOTERM_BP_FAT GO:0043254~regulation of protein complex assembly 6 0.5357142857142857 0.5632301128280983 ARPC1A, ARPC1B, SUMO1, MAPT, RAC1, ADD1 751 90 13528 1.2008877052818465 1.0 0.9954652670995958 99.99996182648397 GOTERM_BP_FAT GO:0030833~regulation of actin filament polymerization 4 0.35714285714285715 0.5822240023687149 ARPC1A, ARPC1B, RAC1, ADD1 751 54 13528 1.334319672535385 1.0 0.9960305609212606 99.99998273099122 GOTERM_BP_FAT GO:0032970~regulation of actin filament-based process 6 0.5357142857142857 0.583006438317732 ARPC1A, ARPC1B, NF2, RAC1, TAC1, ADD1 751 92 13528 1.1747814508191976 1.0 0.9960273673621919 99.99998329900089 GOTERM_BP_FAT GO:0031334~positive regulation of protein complex assembly 3 0.26785714285714285 0.5854336720661045 SUMO1, MAPT, RAC1 751 35 13528 1.5439984782195169 1.0 0.9960729596140963 99.99998495092451 GOTERM_BP_FAT GO:0008064~regulation of actin polymerization or depolymerization 4 0.35714285714285715 0.6650070900080198 ARPC1A, ARPC1B, RAC1, ADD1 751 61 13528 1.1812010215887014 1.0 0.9978974236495349 99.9999996641241 GOTERM_BP_FAT GO:0044087~regulation of cellular component biogenesis 8 0.7142857142857143 0.6787978138143902 ARPC1A, ARPC1B, SUMO1, NF2, MAPT, RAC1, TAC1, ADD1 751 142 13528 1.0148346805198702 1.0 0.998161335875217 99.99999984134483 GOTERM_BP_FAT GO:0030832~regulation of actin filament length 4 0.35714285714285715 0.6863409912708732 ARPC1A, ARPC1B, RAC1, ADD1 751 63 13528 1.1437025764589015 1.0 0.9982381336236708 99.99999989617008 GOTERM_BP_FAT GO:0051130~positive regulation of cellular component organization 9 0.8035714285714285 0.7923937716835473 PLK4, SUMO1, NF2, PLXNB2, MAPT, RAC1, TAC1, RANBP1, NEDD4L 751 181 13528 0.8956897249339738 1.0 0.9994394019336397 99.99999999993409 Annotation Cluster 161 Enrichment Score: 0.3064470375953744 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005578~proteinaceous extracellular matrix 20 1.7857142857142856 0.42215555965038254 TFIP11, WNT10A, ACHE, ADAMTS19, COL3A1, SPOCK1, EMILIN2, COL5A2, EMILIN3, LAMA1, GPC2, EMID1, COL1A2, RELN, LOX, WNT6, SPON2, TFPI2, GPC1, WNT8A 713 320 12782 1.1204417952314165 1.0 0.9490251454210126 99.96139317380099 GOTERM_CC_FAT GO:0044421~extracellular region part 55 4.910714285714286 0.48434909051403857 INSL4, VGF, GPC2, SCRG1, EMID1, LBP, LOX, WNT6, SPON2, TFPI2, GPC1, IHH, F11, TFIP11, WNT10A, F8, INHA, IL21, LEFTY1, GRP, VEGFC, GHRH, SERPINB5, COL1A2, SERPINB2, TFPI, RELN, KDSR, ALDOA, CSF2, TWSG1, ACHE, ADAMTS19, COL3A1, TAC1, SPOCK1, IL33, GREM1, KLKB1, LEFTY2, HGFAC, WNT8A, EPO, IL3, MSTN, EMILIN2, COL5A2, EMILIN3, LAMA1, SFRP4, ARSA, HSPD1, LRP2, VLDLR, IL2 713 960 12782 1.0270716456287985 1.0 0.9578852608342099 99.99244988105964 SP_PIR_KEYWORDS extracellular matrix 14 1.25 0.5240787502156707 WNT10A, ADAMTS19, COL3A1, SPOCK1, EMILIN2, COL5A2, EMILIN3, LAMA1, EMID1, COL1A2, RELN, WNT6, SPON2, WNT8A 1027 241 19235 1.0880096320508106 1.0 0.9353586740604541 99.99806837531922 GOTERM_CC_FAT GO:0031012~extracellular matrix 20 1.7857142857142856 0.5548611237691189 TFIP11, WNT10A, ACHE, ADAMTS19, COL3A1, SPOCK1, EMILIN2, COL5A2, EMILIN3, LAMA1, GPC2, EMID1, COL1A2, RELN, LOX, WNT6, SPON2, TFPI2, GPC1, WNT8A 713 345 12782 1.0392503607943573 1.0 0.9635904984036654 99.9990820627562 Annotation Cluster 162 Enrichment Score: 0.30379793123735566 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:EGF-like 7 4 0.35714285714285715 0.17351659165486716 RELN, LRP2, MEGF10, SCARF2 1024 27 19113 2.7651909722222223 1.0 0.9999919103642804 96.57676133858706 UP_SEQ_FEATURE domain:EGF-like 5 4 0.35714285714285715 0.3772386089345945 RELN, LRP2, MEGF10, SCARF2 1024 41 19113 1.8209794207317074 1.0 0.9999974558090845 99.97719736282168 UP_SEQ_FEATURE domain:EGF-like 8 3 0.26785714285714285 0.38991614178854317 RELN, LRP2, MEGF10 1024 25 19113 2.2398046875 1.0 0.9999978057232672 99.98415761431416 INTERPRO IPR000742:EGF-like, type 3 12 1.0714285714285714 0.5070182304306787 TMEFF2, MUC3A, CRELD2, CCBE1, ZAN, RELN, LRP2, HGFAC, MEGF10, MUC17, SCARF2, VLDLR 920 194 16659 1.120058269834155 1.0 0.999923341486821 99.99904831245557 UP_SEQ_FEATURE domain:EGF-like 3 5 0.4464285714285714 0.5751369613470116 RELN, LRP2, MEGF10, SCARF2, VLDLR 1024 75 19113 1.2443359375 1.0 0.99999994010257 99.99997386156268 UP_SEQ_FEATURE domain:EGF-like 4 4 0.35714285714285715 0.6067124725433922 RELN, LRP2, MEGF10, SCARF2 1024 58 19113 1.287244073275862 1.0 0.999999952527601 99.99999334118034 UP_SEQ_FEATURE domain:EGF-like 1 7 0.625 0.6261086387179805 CRELD2, RELN, LRP2, HGFAC, MEGF10, SCARF2, VLDLR 1024 120 19113 1.0887939453125 1.0 0.9999999652970677 99.99999728068076 UP_SEQ_FEATURE domain:EGF-like 6 3 0.26785714285714285 0.6780584647848461 RELN, MEGF10, SCARF2 1024 43 19113 1.3022120276162792 1.0 0.9999999910880367 99.99999980767195 INTERPRO IPR013111:EGF, extracellular 4 0.35714285714285715 0.6829173382964313 RELN, ADAM22, MEGF10, SCARF2 920 63 16659 1.1496894409937888 1.0 0.9999930364515832 99.99999929963727 UP_SEQ_FEATURE domain:EGF-like 2 5 0.4464285714285714 0.6998896581201263 RELN, LRP2, HGFAC, MEGF10, SCARF2 1024 88 19113 1.060513583096591 1.0 0.999999995404755 99.99999994453248 Annotation Cluster 163 Enrichment Score: 0.303199348788297 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR008266:Tyrosine protein kinase, active site 8 0.7142857142857143 0.2874754969725839 EPHA4, PLK4, FGFR3, LMTK2, JAK2, YES1, EPHB4, SRC 920 97 16659 1.4934110264455402 1.0 0.9989369442549841 99.60770122015468 GOTERM_MF_FAT GO:0004713~protein tyrosine kinase activity 12 1.0714285714285714 0.32158136250779973 EPHA4, PLK4, CRKL, FGFR3, ZAK, NEK1, LMTK2, JAK2, CLK1, YES1, EPHB4, SRC 725 166 12983 1.294524304113004 1.0 0.991242620274217 99.75668883102293 SP_PIR_KEYWORDS tyrosine-protein kinase 8 0.7142857142857143 0.3805152061937298 EPHA4, FGFR3, NEK1, JAK2, CLK1, YES1, EPHB4, SRC 1027 111 19235 1.3498600840372992 1.0 0.8976886783786303 99.90885768571763 GOTERM_MF_FAT GO:0004715~non-membrane spanning protein tyrosine kinase activity 4 0.35714285714285715 0.4025927812737434 JAK2, CLK1, YES1, SRC 725 41 12983 1.747081581160639 1.0 0.9956900777070927 99.9661572363916 INTERPRO IPR001245:Tyrosine protein kinase 7 0.625 0.6393428442505527 FGFR3, ZAK, LMTK2, JAK2, YES1, EPHB4, SRC 920 118 16659 1.0741801768607222 1.0 0.9999857479860643 99.99999425196434 SMART SM00219:TyrKc 7 0.625 0.6612572482367302 FGFR3, ZAK, LMTK2, JAK2, YES1, EPHB4, SRC 513 118 9079 1.049872798757723 1.0 0.9980978370238583 99.99993519921901 GOTERM_BP_FAT GO:0046777~protein amino acid autophosphorylation 5 0.4464285714285714 0.7007584399065303 EIF2AK1, LMTK2, JAK2, CLK1, YES1 751 85 13528 1.0596067987780997 1.0 0.9984321822609613 99.99999995515364 GOTERM_MF_FAT GO:0004714~transmembrane receptor protein tyrosine kinase activity 3 0.26785714285714285 0.8945464853553492 EPHA4, FGFR3, EPHB4 725 67 12983 0.8018322182192487 1.0 0.9999720614432301 99.99999999999993 Annotation Cluster 164 Enrichment Score: 0.3028810073419763 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR002067:Mitochondrial carrier protein 4 0.35714285714285715 0.1846345049991398 SLC25A12, SLC25A31, SLC25A1, SLC25A40 920 27 16659 2.682608695652174 1.0 0.9977370607055371 96.44519787128564 INTERPRO IPR002113:Adenine nucleotide translocator 1 3 0.26785714285714285 0.42424849458815617 SLC25A12, SLC25A31, SLC25A1 920 26 16659 2.089339464882943 1.0 0.999759298451631 99.98796634201099 UP_SEQ_FEATURE repeat:Solcar 3 4 0.35714285714285715 0.5187338248730586 SLC25A12, SLC25A31, SLC25A1, SLC25A40 1024 51 19113 1.4639246323529411 1.0 0.9999998125793895 99.99976237573553 INTERPRO IPR001993:Mitochondrial substrate carrier 4 0.35714285714285715 0.5528082189302764 SLC25A12, SLC25A31, SLC25A1, SLC25A40 920 52 16659 1.3928929765886289 1.0 0.999953146784515 99.99980663337638 UP_SEQ_FEATURE repeat:Solcar 1 4 0.35714285714285715 0.557759305639942 SLC25A12, SLC25A31, SLC25A1, SLC25A40 1024 54 19113 1.3825954861111112 1.0 0.9999999201662118 99.99994684306428 UP_SEQ_FEATURE repeat:Solcar 2 4 0.35714285714285715 0.557759305639942 SLC25A12, SLC25A31, SLC25A1, SLC25A40 1024 54 19113 1.3825954861111112 1.0 0.9999999201662118 99.99994684306428 INTERPRO IPR018108:Mitochondrial substrate/solute carrier 4 0.35714285714285715 0.603621833777279 SLC25A12, SLC25A31, SLC25A1, SLC25A40 920 56 16659 1.2934006211180125 1.0 0.9999742093992091 99.99997308324421 SP_PIR_KEYWORDS mitochondrion inner membrane 8 0.7142857142857143 0.8950372614519206 SLC25A12, NDUFB3, ATP5J2, SLC25A31, NDUFV2, COQ10B, SLC25A1, SLC25A40 1027 193 19235 0.776344400663939 1.0 0.995742030725788 99.99999999999952 Annotation Cluster 165 Enrichment Score: 0.3022853818810142 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001503~ossification 8 0.7142857142857143 0.45571685686272173 TWSG1, ACHE, TNFRSF11A, BCL2, SP3, NAB1, COL5A2, IHH 751 115 13528 1.2531002142071443 1.0 0.9928556014099797 99.99806419325567 GOTERM_BP_FAT GO:0001501~skeletal system development 19 1.6964285714285714 0.5158530154246966 TWSG1, ACHE, FGFR3, UFD1L, COL3A1, TBX1, INHA, GJA5, COL5A2, DLX2, DLX1, TNFRSF11A, DLX6, SP3, BCL2, DLX5, NAB1, COL1A2, IHH 751 319 13528 1.0728934044054113 1.0 0.9947965470191832 99.99976028732638 GOTERM_BP_FAT GO:0060348~bone development 8 0.7142857142857143 0.5271361343844115 TWSG1, ACHE, TNFRSF11A, BCL2, SP3, NAB1, COL5A2, IHH 751 123 13528 1.171597761250582 1.0 0.9950960854398075 99.99984260900777 Annotation Cluster 166 Enrichment Score: 0.3010486468756825 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS ribosome biogenesis 6 0.5357142857142857 0.11123085225931534 NOP14, RCL1, GTPBP10, WDR12, NOP58, NOP10 1027 48 19235 2.341163583252191 1.0 0.7382621934171799 82.16176584227219 SP_PIR_KEYWORDS rrna processing 5 0.4464285714285714 0.41100975774503845 NOP14, EXOSC9, WDR12, TFB2M, NOP10 1027 61 19235 1.5351892349194693 1.0 0.9054630268094574 99.95642505843459 GOTERM_BP_FAT GO:0042254~ribosome biogenesis 8 0.7142857142857143 0.5183858419992662 NOP14, RCL1, EXOSC9, GTPBP10, WDR12, TFB2M, NOP58, NOP10 751 122 13528 1.1812010215887014 1.0 0.9949207538991102 99.99978170211004 GOTERM_BP_FAT GO:0006364~rRNA processing 6 0.5357142857142857 0.583006438317732 NOP14, EXOSC9, WDR12, TFB2M, NOP58, NOP10 751 92 13528 1.1747814508191976 1.0 0.9960273673621919 99.99998329900089 GOTERM_BP_FAT GO:0016072~rRNA metabolic process 6 0.5357142857142857 0.6210595802007867 NOP14, EXOSC9, WDR12, TFB2M, NOP58, NOP10 751 96 13528 1.125832223701731 1.0 0.9969381140147401 99.9999969709926 GOTERM_BP_FAT GO:0022613~ribonucleoprotein complex biogenesis 10 0.8928571428571428 0.672743474359379 NOP14, PHAX, RCL1, EXOSC9, GTPBP10, WDR12, TFB2M, NOP58, NOP10, TXNL4A 751 180 13528 1.0007397544015386 1.0 0.9980358493188455 99.99999977861854 GOTERM_BP_FAT GO:0034470~ncRNA processing 10 0.8928571428571428 0.7157461469427973 NOP14, SRRT, EXOSC9, DGCR8, WDR12, TFB2M, NOP58, SSB, NOP10, POP7 751 187 13528 0.9632789079800907 1.0 0.9985597097124976 99.99999998206933 GOTERM_BP_FAT GO:0034660~ncRNA metabolic process 9 0.8035714285714285 0.945072589214953 NOP14, EXOSC9, WDR12, TFB2M, MARS2, NOP58, SSB, NOP10, POP7 751 230 13528 0.7048688704915186 1.0 0.9999925220699428 100.0 Annotation Cluster 167 Enrichment Score: 0.30023254268628236 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008584~male gonad development 6 0.5357142857142857 0.1598514172758459 HMGB2, BCL2, DMRT1, DMRT2, INHA, HSD17B4 751 52 13528 2.078459489910888 1.0 0.9824491278156547 95.5286352723849 GOTERM_BP_FAT GO:0046546~development of primary male sexual characteristics 6 0.5357142857142857 0.2917923662337483 HMGB2, BCL2, DMRT1, DMRT2, INHA, HSD17B4 751 65 13528 1.6627675919287106 1.0 0.9852505123169953 99.78781184350781 GOTERM_BP_FAT GO:0046661~male sex differentiation 6 0.5357142857142857 0.38058519457777285 HMGB2, BCL2, DMRT1, DMRT2, INHA, HSD17B4 751 73 13528 1.4805464859639204 1.0 0.9895575142188829 99.9805575287798 GOTERM_BP_FAT GO:0001541~ovarian follicle development 4 0.35714285714285715 0.39893272355193987 ERMP1, BCL2, INHA, VGF 751 41 13528 1.7573966418758729 1.0 0.9904918093893557 99.98862961100954 GOTERM_BP_FAT GO:0008406~gonad development 8 0.7142857142857143 0.4283144184408971 ERMP1, HMGB2, BCL2, DMRT1, DMRT2, INHA, HSD17B4, VGF 751 112 13528 1.286665398516264 1.0 0.9919838945890868 99.99535001324111 GOTERM_BP_FAT GO:0022602~ovulation cycle process 5 0.4464285714285714 0.4526769537896687 ERMP1, BCL2, MSTN, INHA, VGF 751 62 13528 1.452686740260298 1.0 0.9928437410815578 99.99786195603494 GOTERM_BP_FAT GO:0042698~ovulation cycle 5 0.4464285714285714 0.5134682986243027 ERMP1, BCL2, MSTN, INHA, VGF 751 67 13528 1.3442772820319178 1.0 0.9948985351240869 99.99973832511834 GOTERM_BP_FAT GO:0048608~reproductive structure development 8 0.7142857142857143 0.5530075837541903 ERMP1, HMGB2, BCL2, DMRT1, DMRT2, INHA, HSD17B4, VGF 751 126 13528 1.1437025764589015 1.0 0.9954151053078927 99.99994232088073 GOTERM_BP_FAT GO:0045137~development of primary sexual characteristics 8 0.7142857142857143 0.5614947830014676 ERMP1, HMGB2, BCL2, DMRT1, DMRT2, INHA, HSD17B4, VGF 751 127 13528 1.1346970443608 1.0 0.9954053119787061 99.9999590281423 GOTERM_BP_FAT GO:0048511~rhythmic process 8 0.7142857142857143 0.5699089404201368 PHLPP1, ERMP1, SRRD, GHRH, BCL2, MSTN, INHA, VGF 751 128 13528 1.125832223701731 1.0 0.99562701243897 99.99997100216547 GOTERM_BP_FAT GO:0007548~sex differentiation 9 0.8035714285714285 0.6037923765936329 ERMP1, HMGB2, DMRT3, BCL2, DMRT1, DMRT2, INHA, HSD17B4, VGF 751 151 13528 1.0736413259142334 1.0 0.9965081192667111 99.99999329256066 GOTERM_BP_FAT GO:0009266~response to temperature stimulus 5 0.4464285714285714 0.6827915684408095 XYLT1, BCL2, MSTN, CETN1, VGF 751 83 13528 1.08513949272456 1.0 0.9981953098959779 99.99999987308571 GOTERM_BP_FAT GO:0008585~female gonad development 4 0.35714285714285715 0.6966201803615009 ERMP1, BCL2, INHA, VGF 751 64 13528 1.125832223701731 1.0 0.9984147694424113 99.99999994270132 GOTERM_BP_FAT GO:0046660~female sex differentiation 4 0.35714285714285715 0.7441954661006629 ERMP1, BCL2, INHA, VGF 751 69 13528 1.0442501785059535 1.0 0.9989499576020247 99.99999999726779 GOTERM_BP_FAT GO:0046545~development of primary female sexual characteristics 4 0.35714285714285715 0.7441954661006629 ERMP1, BCL2, INHA, VGF 751 69 13528 1.0442501785059535 1.0 0.9989499576020247 99.99999999726779 GOTERM_BP_FAT GO:0003006~reproductive developmental process 13 1.1607142857142858 0.7918528523050282 ERMP1, HMGB2, DMRT3, ADAD1, DMRT1, DMRT2, MOV10L1, INHA, VGF, NME5, BCL2, LEFTY2, HSD17B4 751 262 13528 0.8937904676716031 1.0 0.9994469028490892 99.99999999993096 Annotation Cluster 168 Enrichment Score: 0.3001605172241258 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003777~microtubule motor activity 7 0.625 0.258480027844674 KIF22, KIF1A, DNAH14, DNAH7, DYNC1I2, KIF26B, KIF20A 725 77 12983 1.627962382445141 1.0 0.9910326549668913 99.03323367244347 SP_PIR_KEYWORDS dynein 3 0.26785714285714285 0.5150661778061705 DNAH14, DNAH7, DYNC1I2 1027 32 19235 1.755872687439143 1.0 0.9331654648454933 99.99745886146842 GOTERM_CC_FAT GO:0030286~dynein complex 3 0.26785714285714285 0.5721505772793147 DNAH14, DNAH7, DYNC1I2 713 34 12782 1.5818001815031761 1.0 0.9633715296464713 99.99947968640211 GOTERM_CC_FAT GO:0005875~microtubule associated complex 5 0.4464285714285714 0.82709913435446 HAUS3, DNAH14, MAPT, DNAH7, DYNC1I2 713 102 12782 0.8787778786128757 1.0 0.9921237374862728 99.99999999880504 Annotation Cluster 169 Enrichment Score: 0.2931979599015512 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:PH 15 1.3392857142857142 0.39113329336734454 ALS2, PHLPP1, ANLN, TECPR1, RAPH1, ELMO1, PLCL1, KIF1A, SBF1, DOK6, DOK7, SH2B2, RASA4, AKT3, SH3BP2 1024 237 19113 1.1813315862341773 1.0 0.9999976241858042 99.98470804961444 INTERPRO IPR011993:Pleckstrin homology-type 18 1.607142857142857 0.5014590163172803 ENAH, GULP1, ANLN, RAPH1, ELMO1, EPB41L3, PLCL1, KIF1A, EPB41L1, SBF1, PLCG1, DOK6, DOK7, MAPK8IP2, RANBP1, RASA4, AKT3, SH3BP2 920 303 16659 1.0756995264743867 1.0 0.9999190803503201 99.99885683809445 INTERPRO IPR001849:Pleckstrin homology 16 1.4285714285714286 0.5675470658916892 ALS2, PHLPP1, ANLN, TECPR1, RAPH1, ELMO1, PLCL1, KIF1A, SBF1, PLCG1, DOK6, DOK7, SH2B2, RASA4, AKT3, SH3BP2 920 277 16659 1.0459268560665516 1.0 0.9999625061312637 99.99988820008556 SMART SM00233:PH 16 1.4285714285714286 0.6034566095554811 ALS2, PHLPP1, ANLN, TECPR1, RAPH1, ELMO1, PLCL1, KIF1A, SBF1, PLCG1, DOK6, DOK7, SH2B2, RASA4, AKT3, SH3BP2 513 277 9079 1.0222588159126256 1.0 0.9974970385691813 99.99948451463754 Annotation Cluster 170 Enrichment Score: 0.2920567896701799 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:PDZ 8 0.7142857142857143 0.3750285111272677 PPP1R9A, RGS12, GORASP2, MPP4, RAPGEF6, PDLIM3, INTU, SHANK3 1024 110 19113 1.3574573863636363 1.0 0.999997871925732 99.97572114174628 INTERPRO IPR001478:PDZ/DHR/GLGF 9 0.8035714285714285 0.5826917404874254 PPP1R9A, RGS12, GORASP2, MPP4, RAPGEF6, PDLIM3, GRID2IP, INTU, SHANK3 920 149 16659 1.0937481762474468 1.0 0.9999676070433934 99.999937576414 SMART SM00228:PDZ 9 0.8035714285714285 0.608592341808668 PPP1R9A, RGS12, GORASP2, MPP4, RAPGEF6, PDLIM3, GRID2IP, INTU, SHANK3 513 149 9079 1.0689979983515836 1.0 0.9969681443817601 99.99956579563684 Annotation Cluster 171 Enrichment Score: 0.28681253947629654 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0042166~acetylcholine binding 4 0.35714285714285715 0.10894671742664222 CHRM5, ACHE, CHRNA7, CHRNA1 725 21 12983 3.410968801313629 1.0 0.9517127023319999 83.29307695565505 GOTERM_MF_FAT GO:0042165~neurotransmitter binding 9 0.8035714285714285 0.21604883611358022 QRFPR, CHRM5, ACHE, GALR1, GLRA3, MC2R, CHRNA7, NPY6R, CHRNA1 725 103 12983 1.5647405423501841 1.0 0.9898239875342837 97.70812233650102 GOTERM_MF_FAT GO:0015464~acetylcholine receptor activity 3 0.26785714285714285 0.26555573033642405 CHRM5, CHRNA7, CHRNA1 725 18 12983 2.9845977011494256 1.0 0.9908554253352713 99.16683949029085 GOTERM_MF_FAT GO:0030594~neurotransmitter receptor activity 8 0.7142857142857143 0.27888823332606194 QRFPR, CHRM5, GALR1, GLRA3, MC2R, CHRNA7, NPY6R, CHRNA1 725 95 12983 1.5080072595281304 1.0 0.9904109759976156 99.37293924547323 SP_PIR_KEYWORDS postsynaptic cell membrane 7 0.625 0.5371006842166278 DLGAP1, CHRM5, GLRA3, GRID2IP, CHRNA7, CHRNA1, SHANK3 1027 110 19235 1.1918650969283882 1.0 0.9405455693452105 99.99871238427454 GOTERM_MF_FAT GO:0043176~amine binding 7 0.625 0.5814880756868044 CHRM5, ACHE, GLRA3, CHRNA7, CHRNA1, AGXT, SLC1A1 725 110 12983 1.1395736677115988 1.0 0.9989567943088312 99.99986452425829 PIR_SUPERFAMILY PIRSF002443:acetylcholine receptor 3 0.26785714285714285 0.6087242494948762 GLRA3, CHRNA7, CHRNA1 395 38 7396 1.4782145236508994 1.0 0.9999999999462263 99.99976946444853 GOTERM_CC_FAT GO:0045211~postsynaptic membrane 8 0.7142857142857143 0.6316090049724821 DLGAP1, CHRM5, GLRA3, DLGAP4, GRID2IP, CHRNA7, CHRNA1, SHANK3 713 135 12782 1.0623448132564541 1.0 0.9665158108082536 99.9999390392547 INTERPRO IPR006202:Neurotransmitter-gated ion-channel ligand-binding 3 0.26785714285714285 0.7181775366464207 GLRA3, CHRNA7, CHRNA1 920 45 16659 1.2071739130434782 1.0 0.9999969298465106 99.99999989805353 INTERPRO IPR006029:Neurotransmitter-gated ion-channel transmembrane region 3 0.26785714285714285 0.7181775366464207 GLRA3, CHRNA7, CHRNA1 920 45 16659 1.2071739130434782 1.0 0.9999969298465106 99.99999989805353 INTERPRO IPR018000:Neurotransmitter-gated ion-channel, conserved site 3 0.26785714285714285 0.7294653246820955 GLRA3, CHRNA7, CHRNA1 920 46 16659 1.180931001890359 1.0 0.9999969950146977 99.99999994774149 INTERPRO IPR006201:Neurotransmitter-gated ion-channel 3 0.26785714285714285 0.7294653246820955 GLRA3, CHRNA7, CHRNA1 920 46 16659 1.180931001890359 1.0 0.9999969950146977 99.99999994774149 GOTERM_MF_FAT GO:0005230~extracellular ligand-gated ion channel activity 4 0.35714285714285715 0.7732679271276282 P2RX6, GLRA3, CHRNA7, CHRNA1 725 72 12983 0.9948659003831417 1.0 0.9997380976910468 99.99999998994002 SP_PIR_KEYWORDS neurotransmitter receptor 3 0.26785714285714285 0.815287266583843 CHRM5, CHRNA7, CHRNA1 1027 57 19235 0.9857530876851329 1.0 0.9874190030632661 99.99999999810765 GOTERM_MF_FAT GO:0015276~ligand-gated ion channel activity 6 0.5357142857142857 0.8434011607109002 TRPC3, P2RX6, RYR3, GLRA3, CHRNA7, CHRNA1 725 127 12983 0.8460276948140104 1.0 0.9999126681902859 99.99999999996768 GOTERM_MF_FAT GO:0022834~ligand-gated channel activity 6 0.5357142857142857 0.8434011607109002 TRPC3, P2RX6, RYR3, GLRA3, CHRNA7, CHRNA1 725 127 12983 0.8460276948140104 1.0 0.9999126681902859 99.99999999996768 Annotation Cluster 172 Enrichment Score: 0.28446049528358835 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS methyltransferase 10 0.8928571428571428 0.3768410717223064 METTL8, TYMS, RNMT, METTL5, METTL4, PRDM6, SMYD3, TFB2M, COMT, MEPCE 1027 146 19235 1.282829360686132 1.0 0.8967903739863032 99.90062804082127 GOTERM_MF_FAT GO:0008170~N-methyltransferase activity 4 0.35714285714285715 0.5734529818252311 RNMT, PRDM6, SMYD3, TFB2M 725 53 12983 1.3515159401431358 1.0 0.9989960906533935 99.99981803920402 SP_PIR_KEYWORDS s-adenosyl-l-methionine 6 0.5357142857142857 0.6485783814657791 RNMT, PRDM6, SMYD3, TFB2M, COMT, MEPCE 1027 103 19235 1.0910276892825743 1.0 0.9648335051857511 99.99997706393954 Annotation Cluster 173 Enrichment Score: 0.2834094604582005 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001568~blood vessel development 16 1.4285714285714286 0.3917681312561312 COL3A1, TBX20, TBX1, GJA5, VEGFC, TYMP, CRKL, HAND2, ITGAV, ECSCR, CCBE1, CASP8, COL1A2, TGM2, LOX, IHH 751 245 13528 1.1763797929291557 1.0 0.9901844192635458 99.98595290688732 GOTERM_BP_FAT GO:0001944~vasculature development 16 1.4285714285714286 0.4282935962946784 COL3A1, TBX20, TBX1, GJA5, VEGFC, TYMP, CRKL, HAND2, ITGAV, ECSCR, CCBE1, CASP8, COL1A2, TGM2, LOX, IHH 751 251 13528 1.1482591604288572 1.0 0.9921017709023017 99.99534699070554 SP_PIR_KEYWORDS angiogenesis 5 0.4464285714285714 0.4710133122600004 VEGFC, TYMP, HAND2, CCBE1, ECSCR 1027 66 19235 1.4188870201528432 1.0 0.9206210855000245 99.99094120199103 GOTERM_BP_FAT GO:0001525~angiogenesis 9 0.8035714285714285 0.580866694569866 VEGFC, TYMP, HAND2, CCBE1, TBX20, ECSCR, CASP8, TBX1, IHH 751 148 13528 1.0954043257638464 1.0 0.9959991401934445 99.99998170216328 GOTERM_BP_FAT GO:0048514~blood vessel morphogenesis 10 0.8928571428571428 0.833820088642355 VEGFC, TYMP, HAND2, CCBE1, TBX20, ECSCR, CASP8, TGM2, TBX1, IHH 751 211 13528 0.8537116388259571 1.0 0.9997197231283043 99.99999999999875 Annotation Cluster 174 Enrichment Score: 0.2828820887027424 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043623~cellular protein complex assembly 13 1.1607142857142858 0.18832448014307435 AHCTF1, ANLN, SRC, PSMG2, RAC1, MYH11, MAPK8IP2, TUBB6, TUBA4A, TUBA4B, HSPD1, PILRB, SCO2 751 162 13528 1.4455129785800003 1.0 0.9836978400668457 97.58289361878599 GOTERM_BP_FAT GO:0070271~protein complex biogenesis 30 2.6785714285714284 0.45672966530063885 STK16, NAPG, POLR2J, NFS1, AHCTF1, ANLN, SRC, TRIM4, MAZ, CASP8, RAC1, TGM2, TUBB6, WIPF1, SLC1A1, PILRB, SCO2, TAF6, MALT1, COLEC12, NLRP3, ANXA5, P2RX6, PSMG2, MAPK8IP2, MYH11, TUBA4A, TUBA4B, HSPD1, SEPT7 751 505 13528 1.0700979552016454 1.0 0.9928598516506234 99.99812746230731 GOTERM_BP_FAT GO:0006461~protein complex assembly 30 2.6785714285714284 0.45672966530063885 STK16, NAPG, POLR2J, NFS1, AHCTF1, ANLN, SRC, TRIM4, MAZ, CASP8, RAC1, TGM2, TUBB6, WIPF1, SLC1A1, PILRB, SCO2, TAF6, MALT1, COLEC12, NLRP3, ANXA5, P2RX6, PSMG2, MAPK8IP2, MYH11, TUBA4A, TUBA4B, HSPD1, SEPT7 751 505 13528 1.0700979552016454 1.0 0.9928598516506234 99.99812746230731 GOTERM_BP_FAT GO:0034621~cellular macromolecular complex subunit organization 21 1.875 0.525677471550086 HMGB2, ABI2, AHCTF1, ANLN, ETF1, SRC, PHAX, MAZ, PSMG2, SEH1L, RAC1, MAPK8IP2, MYH11, TUBB6, TUBA4A, TUBA4B, HSPD1, WIPF1, PILRB, SCO2, TXNL4A 751 357 13528 1.0596067987780997 1.0 0.9950556109081272 99.99983371833108 GOTERM_BP_FAT GO:0034622~cellular macromolecular complex assembly 16 1.4285714285714286 0.7770967448685581 HMGB2, AHCTF1, ANLN, SRC, PHAX, PSMG2, RAC1, MAPK8IP2, MYH11, TUBA4A, TUBB6, TUBA4B, HSPD1, PILRB, SCO2, TXNL4A 751 318 13528 0.9063303436089408 1.0 0.9993494660625498 99.99999999976569 GOTERM_BP_FAT GO:0043933~macromolecular complex subunit organization 36 3.214285714285714 0.7916339146574675 STK16, HMGB2, NAPG, POLR2J, NFS1, AHCTF1, ABI2, ANLN, SRC, TRIM4, MAZ, SEH1L, CASP8, RAC1, TGM2, TUBB6, WIPF1, SLC1A1, PILRB, SCO2, TAF6, MALT1, COLEC12, ANXA5, ETF1, NLRP3, PHAX, P2RX6, PSMG2, MAPK8IP2, MYH11, TUBA4A, TUBA4B, HSPD1, SEPT7, TXNL4A 751 710 13528 0.9133512124678832 1.0 0.9994583970593877 99.99999999992966 GOTERM_BP_FAT GO:0065003~macromolecular complex assembly 33 2.946428571428571 0.8239129211811261 STK16, HMGB2, NAPG, POLR2J, NFS1, AHCTF1, ANLN, SRC, TRIM4, MAZ, CASP8, RAC1, TGM2, TUBB6, WIPF1, SLC1A1, PILRB, SCO2, TAF6, MALT1, COLEC12, ANXA5, NLRP3, PHAX, P2RX6, PSMG2, MAPK8IP2, MYH11, TUBA4A, TUBA4B, HSPD1, SEPT7, TXNL4A 751 665 13528 0.8938938558112991 1.0 0.9996628429797864 99.9999999999965 Annotation Cluster 175 Enrichment Score: 0.2698138984502943 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0070304~positive regulation of stress-activated protein kinase signaling pathway 3 0.26785714285714285 0.3260881212751439 TAOK2, MAPK8IP2, TLR3 751 21 13528 2.5733307970325283 1.0 0.9878826382571414 99.91247849890985 GOTERM_BP_FAT GO:0046328~regulation of JNK cascade 5 0.4464285714285714 0.4894972686714876 AIDA, ZAK, TAOK2, MAPK8IP2, TLR3 751 65 13528 1.385639659940592 1.0 0.9939991715635182 99.999382829886 GOTERM_BP_FAT GO:0080135~regulation of cellular response to stress 7 0.625 0.5105844595748477 BRCC3, AIDA, ZAK, TAOK2, FAM175A, MAPK8IP2, TLR3 751 103 13528 1.224205913151397 1.0 0.9947464602529621 99.99970922781192 GOTERM_BP_FAT GO:0070302~regulation of stress-activated protein kinase signaling pathway 5 0.4464285714285714 0.536908470203118 AIDA, ZAK, TAOK2, MAPK8IP2, TLR3 751 69 13528 1.3053127231324417 1.0 0.9951510955911821 99.99989156362007 GOTERM_BP_FAT GO:0043408~regulation of MAPKKK cascade 6 0.5357142857142857 0.729424971916762 AIDA, ZAK, NF2, TAOK2, MAPK8IP2, TLR3 751 109 13528 0.9915586557373043 1.0 0.9987207020633817 99.99999999256181 GOTERM_BP_FAT GO:0043410~positive regulation of MAPKKK cascade 3 0.26785714285714285 0.7534993514521742 TAOK2, MAPK8IP2, TLR3 751 48 13528 1.125832223701731 1.0 0.9990357186474436 99.99999999858925 Annotation Cluster 176 Enrichment Score: 0.2685113532046178 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009267~cellular response to starvation 4 0.35714285714285715 0.26053521949582087 ATG9A, ATG12, BMPR2, ASNS 751 32 13528 2.251664447403462 1.0 0.9838685333415731 99.5414759773419 GOTERM_BP_FAT GO:0042594~response to starvation 4 0.35714285714285715 0.4140669122585251 ATG9A, ATG12, BMPR2, ASNS 751 42 13528 1.7155538646883521 1.0 0.991325357664011 99.99278584307227 GOTERM_BP_FAT GO:0031669~cellular response to nutrient levels 4 0.35714285714285715 0.4439484418354328 ATG9A, ATG12, BMPR2, ASNS 751 44 13528 1.6375741435661544 1.0 0.9926431770001295 99.9971646432946 GOTERM_BP_FAT GO:0031668~cellular response to extracellular stimulus 5 0.4464285714285714 0.47733081313688175 ATG9A, ATG12, ITGA6, BMPR2, ASNS 751 64 13528 1.4072902796271636 1.0 0.9934854568536916 99.99906049952139 GOTERM_BP_FAT GO:0031667~response to nutrient levels 10 0.8928571428571428 0.770480082272324 ATG9A, ATG12, GHRH, BCL2, ARSA, BMPR2, ASNS, LRP2, STAT1, VLDLR 751 197 13528 0.9143815014836394 1.0 0.9992684006072436 99.99999999960517 GOTERM_BP_FAT GO:0009991~response to extracellular stimulus 11 0.9821428571428571 0.7841160987655375 ATG9A, ATG12, ITGA6, GHRH, BCL2, ARSA, BMPR2, ASNS, LRP2, STAT1, VLDLR 751 220 13528 0.9006657789613848 1.0 0.9994135668072212 99.99999999986761 GOTERM_BP_FAT GO:0007584~response to nutrient 5 0.4464285714285714 0.9554099648650141 BCL2, ARSA, LRP2, STAT1, VLDLR 751 140 13528 0.6433326992581321 1.0 0.9999960110293133 100.0 Annotation Cluster 177 Enrichment Score: 0.26168559509314626 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0014031~mesenchymal cell development 4 0.35714285714285715 0.5430120746542353 HAND2, BCL2, TBX1, NFATC1 751 51 13528 1.4128090650374665 1.0 0.9950792468993662 99.99991441978236 GOTERM_BP_FAT GO:0048762~mesenchymal cell differentiation 4 0.35714285714285715 0.5430120746542353 HAND2, BCL2, TBX1, NFATC1 751 51 13528 1.4128090650374665 1.0 0.9950792468993662 99.99991441978236 GOTERM_BP_FAT GO:0060485~mesenchyme development 4 0.35714285714285715 0.5563194461896196 HAND2, BCL2, TBX1, NFATC1 751 52 13528 1.385639659940592 1.0 0.9954041025064895 99.99994948776472 Annotation Cluster 178 Enrichment Score: 0.2603093032226299 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Rho-GAP 6 0.5357142857142857 0.2676279607982625 ARHGAP40, RALBP1, ARHGAP28, CHN1, ARHGAP11A, FAM13B 1024 65 19113 1.7229266826923075 1.0 0.9999965442316785 99.59750557473565 INTERPRO IPR000198:RhoGAP 6 0.5357142857142857 0.3101360376923644 ARHGAP40, RALBP1, ARHGAP28, CHN1, ARHGAP11A, FAM13B 920 67 16659 1.6215768981181051 1.0 0.9987412166995637 99.76871091050583 SMART SM00324:RhoGAP 6 0.5357142857142857 0.3264274027463455 ARHGAP40, RALBP1, ARHGAP28, CHN1, ARHGAP11A, FAM13B 513 67 9079 1.5848826045212532 1.0 0.9864224194756183 99.4492075722836 SP_PIR_KEYWORDS GTPase activation 9 0.8035714285714285 0.6180363255223874 ARHGAP40, RALBP1, RALGAPB, ARHGAP28, CHN1, RANBP1, ARHGAP11A, RASA4, FAM13B 1027 159 19235 1.0601495471330677 1.0 0.9611842652622465 99.99992244162257 GOTERM_MF_FAT GO:0008047~enzyme activator activity 18 1.607142857142857 0.6918578589063336 ALS2, AIFM3, CDK5R2, RALBP1, AGFG2, DBF4, RALGAPB, ARHGAP28, MALT1, FAM13B, ARHGAP40, RGS12, MAPK8IP2, CHN1, RANBP1, ARHGAP11A, RASA4, IL2 725 335 12983 0.9621986618630982 1.0 0.9994184619937269 99.99999882669256 GOTERM_MF_FAT GO:0005096~GTPase activator activity 11 0.9821428571428571 0.7901579887274729 ARHGAP40, RGS12, RALBP1, AGFG2, RALGAPB, ARHGAP28, CHN1, RANBP1, ARHGAP11A, RASA4, FAM13B 725 220 12983 0.8953793103448277 1.0 0.9997993705758363 99.9999999969726 GOTERM_MF_FAT GO:0030695~GTPase regulator activity 17 1.5178571428571428 0.9452485962024235 ALS2, RALBP1, AGFG2, RALGAPB, ARHGAP28, DOCK8, FAM13B, ARHGAP40, RGS12, KRIT1, CHN1, RAPGEF6, RAPGEF4, RANBP1, ARHGAP11A, RASA4, FBXO8 725 404 12983 0.7535370433595083 1.0 0.9999963846305556 100.0 GOTERM_MF_FAT GO:0060589~nucleoside-triphosphatase regulator activity 17 1.5178571428571428 0.9557941960868795 ALS2, RALBP1, AGFG2, RALGAPB, ARHGAP28, DOCK8, FAM13B, ARHGAP40, RGS12, KRIT1, CHN1, RAPGEF6, RAPGEF4, RANBP1, ARHGAP11A, RASA4, FBXO8 725 413 12983 0.7371161392669283 1.0 0.9999983596791592 100.0 Annotation Cluster 179 Enrichment Score: 0.2512444627591205 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048736~appendage development 7 0.625 0.5105844595748477 RAX, DLX6, DLX5, FBXW4, PSEN2, GREM1, GJA5 751 103 13528 1.224205913151397 1.0 0.9947464602529621 99.99970922781192 GOTERM_BP_FAT GO:0060173~limb development 7 0.625 0.5105844595748477 RAX, DLX6, DLX5, FBXW4, PSEN2, GREM1, GJA5 751 103 13528 1.224205913151397 1.0 0.9947464602529621 99.99970922781192 GOTERM_BP_FAT GO:0035113~embryonic appendage morphogenesis 6 0.5357142857142857 0.5327078724060125 DLX6, DLX5, FBXW4, PSEN2, GREM1, GJA5 751 87 13528 1.2422976261536343 1.0 0.9951720271378964 99.99987260845464 GOTERM_BP_FAT GO:0030326~embryonic limb morphogenesis 6 0.5357142857142857 0.5327078724060125 DLX6, DLX5, FBXW4, PSEN2, GREM1, GJA5 751 87 13528 1.2422976261536343 1.0 0.9951720271378964 99.99987260845464 GOTERM_BP_FAT GO:0035107~appendage morphogenesis 6 0.5357142857142857 0.6482013103028785 DLX6, DLX5, FBXW4, PSEN2, GREM1, GJA5 751 99 13528 1.0917160957107694 1.0 0.9975798014311553 99.99999919563581 GOTERM_BP_FAT GO:0035108~limb morphogenesis 6 0.5357142857142857 0.6482013103028785 DLX6, DLX5, FBXW4, PSEN2, GREM1, GJA5 751 99 13528 1.0917160957107694 1.0 0.9975798014311553 99.99999919563581 Annotation Cluster 180 Enrichment Score: 0.24875836365494355 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR000859:CUB 4 0.35714285714285715 0.5395144579678437 SEZ6L2, KREMEN1, PCOLCE, NETO1 920 51 16659 1.4202046035805627 1.0 0.9999440110930892 99.99968785250337 SMART SM00042:CUB 4 0.35714285714285715 0.5549741002656036 SEZ6L2, KREMEN1, PCOLCE, NETO1 513 51 9079 1.3880671176852806 1.0 0.996470503381231 99.99764700123066 UP_SEQ_FEATURE domain:CUB 1 3 0.26785714285714285 0.5812264519617635 SEZ6L2, PCOLCE, NETO1 1024 36 19113 1.555419921875 1.0 0.9999999418696862 99.99997975770381 UP_SEQ_FEATURE domain:CUB 2 3 0.26785714285714285 0.5812264519617635 SEZ6L2, PCOLCE, NETO1 1024 36 19113 1.555419921875 1.0 0.9999999418696862 99.99997975770381 Annotation Cluster 181 Enrichment Score: 0.24870935952384993 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:PID 3 0.26785714285714285 0.4464234416176572 RGS12, GULP1, MAPK8IP2 1024 28 19113 1.9998256138392856 1.0 0.9999986597730182 99.9971662513075 INTERPRO IPR006020:Phosphotyrosine interaction region 3 0.26785714285714285 0.6277530912791587 RGS12, GULP1, MAPK8IP2 920 38 16659 1.4295480549199084 1.0 0.999984732383867 99.99999035992872 SMART SM00462:PTB 3 0.26785714285714285 0.640230073172919 RGS12, GULP1, MAPK8IP2 513 38 9079 1.397199138196368 1.0 0.9979278703811899 99.9998568267186 Annotation Cluster 182 Enrichment Score: 0.2487073911577987 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007601~visual perception 13 1.1607142857142858 0.5396325677993761 GJA8, GJD2, BBS5, RAX, BBS7, BBS9, MYO3B, RP9, CYP4V2, KCNV2, CRYBB1, CRYBA4, ABCC6 751 216 13528 1.0841347339350003 1.0 0.9951548117040203 99.99990239723985 GOTERM_BP_FAT GO:0050953~sensory perception of light stimulus 13 1.1607142857142858 0.5396325677993761 GJA8, GJD2, BBS5, RAX, BBS7, BBS9, MYO3B, RP9, CYP4V2, KCNV2, CRYBB1, CRYBA4, ABCC6 751 216 13528 1.0841347339350003 1.0 0.9951548117040203 99.99990239723985 SP_PIR_KEYWORDS vision 8 0.7142857142857143 0.6161430045504357 BBS5, BBS7, BBS9, MYO3B, RP9, CYP4V2, KCNV2, ABCC6 1027 139 19235 1.077945822504606 1.0 0.9613012003818062 99.9999166277994 Annotation Cluster 183 Enrichment Score: 0.24682437473159258 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0048475~coated membrane 6 0.5357142857142857 0.2732970528231804 AP1S1, SEC31A, AP1B1, AP3S1, AP4M1, CLTCL1 713 63 12782 1.7073398784478726 1.0 0.9067228478373294 98.96915292170243 GOTERM_CC_FAT GO:0030117~membrane coat 6 0.5357142857142857 0.2732970528231804 AP1S1, SEC31A, AP1B1, AP3S1, AP4M1, CLTCL1 713 63 12782 1.7073398784478726 1.0 0.9067228478373294 98.96915292170243 GOTERM_CC_FAT GO:0030140~trans-Golgi network transport vesicle 3 0.26785714285714285 0.3896412186362481 AP1S1, STEAP2, CLTCL1 713 24 12782 2.240883590462833 1.0 0.9415055200568749 99.91540243383918 GOTERM_CC_FAT GO:0030658~transport vesicle membrane 3 0.26785714285714285 0.42921637561925036 AP1S1, SEC31A, CLTCL1 713 26 12782 2.0685079296579993 1.0 0.9490169656767504 99.96762960011155 GOTERM_CC_FAT GO:0030667~secretory granule membrane 3 0.26785714285714285 0.4859012326223264 GP1BB, ZG16, VGF 713 29 12782 1.854524350727862 1.0 0.9571727205209081 99.9927691039922 GOTERM_CC_FAT GO:0030133~transport vesicle 5 0.4464285714285714 0.5053263436510397 AP1S1, SEC31A, AP3S1, STEAP2, CLTCL1 713 66 12782 1.3581112669471713 1.0 0.9607475832778882 99.99583632382439 GOTERM_CC_FAT GO:0005798~Golgi-associated vesicle 4 0.35714285714285715 0.5462968171088101 AP1S1, PI4KA, STEAP2, CLTCL1 713 51 12782 1.406044605780601 1.0 0.9617101476215193 99.99879381091414 GOTERM_CC_FAT GO:0012506~vesicle membrane 9 0.8035714285714285 0.6092486362783782 SLC32A1, CLCN3, AP1S1, SEC31A, GP1BB, ZG16, VGF, GAD1, CLTCL1 713 151 12782 1.06850078485645 1.0 0.9661923878504736 99.99985816424474 GOTERM_CC_FAT GO:0030120~vesicle coat 3 0.26785714285714285 0.6332330842051148 AP1S1, SEC31A, CLTCL1 713 38 12782 1.415294899239684 1.0 0.9662188497172378 99.99994277939918 GOTERM_CC_FAT GO:0030135~coated vesicle 9 0.8035714285714285 0.6669173389385514 SLC32A1, SEPT5, AP1S1, DOC2A, SEC31A, HSPD1, STEAP2, SLC40A1, CLTCL1 713 159 12782 1.0147397390775093 1.0 0.9723406427485388 99.99998561211943 GOTERM_BP_FAT GO:0006836~neurotransmitter transport 5 0.4464285714285714 0.6827915684408095 SLC32A1, CPLX4, SEPT5, DOC2A, SERPINB7 751 83 13528 1.08513949272456 1.0 0.9981953098959779 99.99999987308571 GOTERM_CC_FAT GO:0044433~cytoplasmic vesicle part 10 0.8928571428571428 0.7210467902150105 SLC32A1, VEGFC, AP1S1, SEC31A, GP1BB, ZG16, LEFTY2, F8, VGF, CLTCL1 713 187 12782 0.9586667766685917 1.0 0.98128438155019 99.99999886691442 GOTERM_CC_FAT GO:0030136~clathrin-coated vesicle 7 0.625 0.7511933762213909 SLC32A1, SEPT5, AP1S1, DOC2A, STEAP2, SLC40A1, CLTCL1 713 132 12782 0.95067788686302 1.0 0.9845976916309493 99.99999977997007 GOTERM_CC_FAT GO:0030662~coated vesicle membrane 4 0.35714285714285715 0.7806278755070197 SLC32A1, AP1S1, SEC31A, CLTCL1 713 73 12782 0.9823051355453515 1.0 0.9882115039994475 99.99999996378484 GOTERM_CC_FAT GO:0030659~cytoplasmic vesicle membrane 7 0.625 0.7934200392736976 SLC32A1, AP1S1, SEC31A, GP1BB, ZG16, VGF, CLTCL1 713 139 12782 0.9028020220569687 1.0 0.9895506951071574 99.99999998469036 GOTERM_CC_FAT GO:0030665~clathrin coated vesicle membrane 3 0.26785714285714285 0.802769393711698 SLC32A1, AP1S1, CLTCL1 713 53 12782 1.0147397390775093 1.0 0.9900711809083389 99.99999999211639 GOTERM_CC_FAT GO:0008021~synaptic vesicle 4 0.35714285714285715 0.8032567814987623 SLC32A1, SEPT5, DOC2A, SLC40A1 713 76 12782 0.943529932826456 1.0 0.9895966781806336 99.99999999239101 Annotation Cluster 184 Enrichment Score: 0.24426952559974116 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:RGS 3 0.26785714285714285 0.533615944738218 RGS12, SNX25, GRK4 1024 33 19113 1.6968217329545456 1.0 0.9999998749608486 99.9998637509102 INTERPRO IPR000342:Regulator of G protein signalling 3 0.26785714285714285 0.5825995085547864 RGS12, SNX25, GRK4 920 35 16659 1.552080745341615 1.0 0.9999704347127506 99.99993735048804 SMART SM00315:RGS 3 0.26785714285714285 0.5951035091687106 RGS12, SNX25, GRK4 513 35 9079 1.5169590643274853 1.0 0.9975165082636203 99.99932175470202 Annotation Cluster 185 Enrichment Score: 0.24393164069396642 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS electron transport 7 0.625 0.44413998549235567 NDUFB3, AIFM3, NDUFV2, CYBRD1, CYB5A, STEAP2, STEAP1 1027 100 19235 1.3110516066212268 1.0 0.914508505420965 99.98130699661661 GOTERM_BP_FAT GO:0022900~electron transport chain 8 0.7142857142857143 0.44660782062010324 SLC25A12, NDUFB3, AIFM3, NDUFV2, CYBRD1, CYB5A, STEAP2, STEAP1 751 114 13528 1.264092321349312 1.0 0.9927185065449012 99.99739707278457 GOTERM_BP_FAT GO:0006091~generation of precursor metabolites and energy 13 1.1607142857142858 0.9348864818510884 ALDOA, NDUFB3, AIFM3, CYB5A, VGF, ATP5G3, SLC25A12, NDUFV2, CYBRD1, MC4R, STEAP2, STEAP1, CROT 751 313 13528 0.748156877092524 1.0 0.9999871325597386 100.0 Annotation Cluster 186 Enrichment Score: 0.24037520052284791 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044440~endosomal part 5 0.4464285714285714 0.3930685805470619 SLA2, ZFYVE28, VPS4B, TLR3, SP9 713 57 12782 1.5725498880440933 1.0 0.9414235854945672 99.9219609696881 GOTERM_CC_FAT GO:0010008~endosome membrane 5 0.4464285714285714 0.3930685805470619 SLA2, ZFYVE28, VPS4B, TLR3, SP9 713 57 12782 1.5725498880440933 1.0 0.9414235854945672 99.9219609696881 GOTERM_CC_FAT GO:0005770~late endosome 4 0.35714285714285715 0.6104404406092067 CLCN3, SLA2, VPS4B, SP9 713 56 12782 1.2805049088359046 1.0 0.9657102533788374 99.99986423915172 SP_PIR_KEYWORDS endosome 10 0.8928571428571428 0.7896945031750096 CLCN3, CHMP1B, TRAK2, ZFYVE28, VPS4B, TLR3, SP9, STEAP2, STEAP1, MARCH3 1027 209 19235 0.8961391706228483 1.0 0.9840065597005317 99.99999998738662 GOTERM_CC_FAT GO:0005768~endosome 15 1.3392857142857142 0.8434996843021034 ALS2, CLCN3, NF2, SLA2, TLR3, MARCH3, CHMP1B, ZFYVE28, VPS4B, ARSA, HSPD1, LRP2, STEAP2, SP9, STEAP1 713 315 12782 0.8536699392239364 1.0 0.9932928029907375 99.99999999971351 Annotation Cluster 187 Enrichment Score: 0.23765365979653896 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007569~cell aging 4 0.35714285714285715 0.27582046409861966 HTT, BCL2, SERPINE1, ROMO1 751 33 13528 2.183432191421539 1.0 0.9838620344096096 99.68411984099707 GOTERM_BP_FAT GO:0010035~response to inorganic substance 12 1.0714285714285714 0.5886070069289191 SLC25A12, ACTB, SRRT, SEC31A, HTT, BCL2, SERPINE1, CYBRD1, ROMO1, TXNRD2, NEDD4L, STAT1 751 205 13528 1.0544379851255237 1.0 0.9961622557042626 99.99998687884286 GOTERM_BP_FAT GO:0000302~response to reactive oxygen species 5 0.4464285714285714 0.6035745990189572 BCL2, SERPINE1, ROMO1, TXNRD2, STAT1 751 75 13528 1.2008877052818463 1.0 0.9965400234759932 99.99999322647966 GOTERM_BP_FAT GO:0007568~aging 6 0.5357142857142857 0.7367471559382349 HTT, BCL2, SERPINE1, ROMO1, LRP2, ATP5G3 751 110 13528 0.9825444861396925 1.0 0.9988307845377998 99.9999999954407 GOTERM_BP_FAT GO:0006979~response to oxidative stress 7 0.625 0.8979049501532335 ALS2, BCL2, SERPINE1, ROMO1, TXNRD2, JAK2, STAT1 751 164 13528 0.7688610308206943 1.0 0.999943791810268 100.0 Annotation Cluster 188 Enrichment Score: 0.23122733693982073 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010038~response to metal ion 8 0.7142857142857143 0.5782474177691489 SLC25A12, ACTB, SEC31A, HTT, BCL2, CYBRD1, TXNRD2, NEDD4L 751 129 13528 1.117104842122648 1.0 0.9958899529954941 99.99997955110436 GOTERM_BP_FAT GO:0010035~response to inorganic substance 12 1.0714285714285714 0.5886070069289191 SLC25A12, ACTB, SRRT, SEC31A, HTT, BCL2, SERPINE1, CYBRD1, ROMO1, TXNRD2, NEDD4L, STAT1 751 205 13528 1.0544379851255237 1.0 0.9961622557042626 99.99998687884286 GOTERM_BP_FAT GO:0051592~response to calcium ion 4 0.35714285714285715 0.5948108191159199 SLC25A12, ACTB, SEC31A, HTT 751 55 13528 1.3100593148529234 1.0 0.9961881085397631 99.9999899945012 Annotation Cluster 189 Enrichment Score: 0.22932509380450491 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045454~cell redox homeostasis 5 0.4464285714285714 0.4650544644135546 TXNDC2, AIFM3, TMX3, TXNRD2, SCO2 751 63 13528 1.4296282205736266 1.0 0.9929232962050184 99.99857838654383 UP_SEQ_FEATURE domain:Thioredoxin 3 0.26785714285714285 0.533615944738218 TXNDC2, TMX3, SCO2 1024 33 19113 1.6968217329545456 1.0 0.9999998749608486 99.9998637509102 INTERPRO IPR017936:Thioredoxin-like 3 0.26785714285714285 0.5980866463844321 TXNDC2, TMX3, SCO2 920 36 16659 1.5089673913043478 1.0 0.9999724210347241 99.99996623395975 INTERPRO IPR012335:Thioredoxin fold 5 0.4464285714285714 0.8150850038314262 TXNDC2, NDUFV2, TMX3, CLIC2, SCO2 920 101 16659 0.8964162720619888 1.0 0.9999996860545997 99.99999999989609 Annotation Cluster 190 Enrichment Score: 0.22371307653151032 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048193~Golgi vesicle transport 9 0.8035714285714285 0.44160953398490843 AP1S1, SEC31A, NAPG, AP1B1, HTT, BET1, LMAN1, CUX1, STEAP2 751 131 13528 1.2375560321606813 1.0 0.992713549363094 99.9969441602858 GOTERM_CC_FAT GO:0044431~Golgi apparatus part 16 1.4285714285714286 0.6751639089514242 SEC31A, AP1B1, PPIL2, BET1, PI4KA, AP4M1, LMAN1, ABCB4, AP1S1, CHSY3, CHPF, GORASP2, CUX1, STEAP2, CLTCL1, MLANA 713 294 12782 0.9756227876844988 1.0 0.9732355102749153 99.9999899545035 GOTERM_CC_FAT GO:0000139~Golgi membrane 10 0.8928571428571428 0.7151762942727724 AP1S1, CHSY3, AP1B1, CHPF, BET1, LMAN1, CUX1, STEAP2, CLTCL1, ABCB4 713 186 12782 0.9638208991237992 1.0 0.9805306068153888 99.99999847286459 Annotation Cluster 191 Enrichment Score: 0.22292646210647327 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008654~phospholipid biosynthetic process 8 0.7142857142857143 0.33657926473486277 CPT1B, CDIPT, CHKB, PGAP1, AGPAT9, PI4KA, ALG12, LPCAT4, PIGN 751 102 13528 1.4128090650374665 1.0 0.9884619815615773 99.93384766248967 GOTERM_BP_FAT GO:0046489~phosphoinositide biosynthetic process 4 0.35714285714285715 0.38369269345455764 PGAP1, PI4KA, ALG12, PIGN 751 40 13528 1.8013315579227698 1.0 0.9895648442492804 99.98222612701208 SP_PIR_KEYWORDS phospholipid biosynthesis 4 0.35714285714285715 0.38984746566356415 CPT1B, CDIPT, CHKB, AGPAT9, LPCAT4 1027 42 19235 1.7837436824778599 1.0 0.8971255715844441 99.92699560806582 GOTERM_BP_FAT GO:0045017~glycerolipid biosynthetic process 6 0.5357142857142857 0.45814151321995794 CPT1B, CHKB, PGAP1, AGPAT9, PI4KA, ALG12, PIGN 751 80 13528 1.3509986684420772 1.0 0.9928034911109566 99.9982124084268 GOTERM_BP_FAT GO:0046474~glycerophospholipid biosynthetic process 5 0.4464285714285714 0.525258107205379 CPT1B, CHKB, PGAP1, PI4KA, ALG12, PIGN 751 68 13528 1.3245084984726248 1.0 0.9950921252743453 99.99983107582085 GOTERM_BP_FAT GO:0006497~protein amino acid lipidation 4 0.35714285714285715 0.5693919538771506 PGAP1, ALG12, PGGT1B, PIGN 751 53 13528 1.359495515413411 1.0 0.9957036194155368 99.99997037395654 GOTERM_BP_FAT GO:0006506~GPI anchor biosynthetic process 3 0.26785714285714285 0.569501374975967 PGAP1, ALG12, PIGN 751 34 13528 1.5894101981671498 1.0 0.9956556918854602 99.9999705079803 GOTERM_BP_FAT GO:0006505~GPI anchor metabolic process 3 0.26785714285714285 0.5854336720661045 PGAP1, ALG12, PIGN 751 35 13528 1.5439984782195169 1.0 0.9960729596140963 99.99998495092451 GOTERM_BP_FAT GO:0042158~lipoprotein biosynthetic process 4 0.35714285714285715 0.6310635540215259 PGAP1, ALG12, PGGT1B, PIGN 751 58 13528 1.2422976261536343 1.0 0.9972533627706059 99.99999812068505 GOTERM_BP_FAT GO:0008610~lipid biosynthetic process 17 1.5178571428571428 0.7154565463459821 MOGAT3, CPT1B, CDIPT, CYP51A1, CHKB, PGAP1, PRKAB2, RNPEPL1, PI4KA, DHRS9, LSS, LPCAT4, PIGN, COQ2, AGPAT9, SCD5, ALG12, DEGS1 751 323 13528 0.9480692410119841 1.0 0.9985698115638774 99.9999999817406 GOTERM_BP_FAT GO:0006644~phospholipid metabolic process 10 0.8928571428571428 0.7330039359522977 CPT1B, CDIPT, NAPEPLD, PLCG1, CHKB, PGAP1, AGPAT9, PI4KA, ALG12, LPCAT4, PIGN 751 190 13528 0.948069241011984 1.0 0.9987746868406256 99.99999999413463 GOTERM_BP_FAT GO:0030384~phosphoinositide metabolic process 4 0.35714285714285715 0.777815838030387 PGAP1, PI4KA, ALG12, PIGN 751 73 13528 0.9870309906426136 1.0 0.9993512875179825 99.99999999977882 GOTERM_BP_FAT GO:0019637~organophosphate metabolic process 10 0.8928571428571428 0.7853431417941394 CPT1B, CDIPT, NAPEPLD, PLCG1, CHKB, PGAP1, AGPAT9, PI4KA, ALG12, LPCAT4, PIGN 751 200 13528 0.9006657789613849 1.0 0.9994220462690776 99.99999999988042 GOTERM_BP_FAT GO:0006650~glycerophospholipid metabolic process 6 0.5357142857142857 0.7901392984810486 CPT1B, CDIPT, CHKB, PGAP1, PI4KA, ALG12, PIGN 751 118 13528 0.9159313006386965 1.0 0.9994539448522737 99.99999999992009 GOTERM_BP_FAT GO:0042157~lipoprotein metabolic process 4 0.35714285714285715 0.8278532221064837 PGAP1, ALG12, PGGT1B, PIGN 751 80 13528 0.9006657789613849 1.0 0.9996837085215867 99.99999999999767 GOTERM_BP_FAT GO:0046486~glycerolipid metabolic process 7 0.625 0.8914538863719098 CPT1B, CDIPT, CHKB, PGAP1, AGPAT9, PI4KA, ALG12, PIGN 751 162 13528 0.7783531423123079 1.0 0.9999331615949678 100.0 Annotation Cluster 192 Enrichment Score: 0.2207455857125226 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005730~nucleolus 40 3.571428571428571 0.5199374798074458 HMGB2, TAF1A, ZNF532, YPEL3, GTPBP10, PDLIM3, ZNF655, DGCR14, CTNNBL1, KIAA0020, TOP1, WDR75, STAT4, CIR1, DGCR8, CASP8, WDR12, WIPF1, KDM3B, DCAF17, BRD8, EXOSC9, NF2, SSB, STAT1, NOP10, ZNF3, NOP14, NVL, MAPK1, RCL1, PLK4, CSRNP3, DLX5, PRKRIP1, MAPK3, NOP58, PARP1, HPGD, POP7 713 698 12782 1.0273391818740782 1.0 0.9589593004821878 99.99729054754137 GOTERM_CC_FAT GO:0043233~organelle lumen 102 9.107142857142856 0.5340699857896039 MRPL40, MAEA, RNMT, DBF4, PDLIM3, AGXT, CTNNBL1, TOP1, WDR75, TFB2M, CCNA2, PRKAB2, RBL1, F8, HDAC10, ZNF3, NVL, MAPK1, RCL1, VEGFC, MRPS18C, MED15, PRKRIP1, MAPK3, LRCH4, SMARCA2, CROT, HMGB2, LMNB1, PPIL2, AHCTF1, HSPE1, TAF6, MAFB, AK3, CDC23, SSB, NOP10, NOP14, PLK4, PPIG, CSRNP3, DLX5, GLS, HSPD1, PARP1, POP7, TAF1A, ZNF532, GTPBP10, DGCR14, SAP30, CDC45, MCM7, P4HA2, DGCR8, CASP8, DCAF17, BRD8, TFIP11, CTBP1, EXOSC9, LRPAP1, SIL1, RBM39, CTDP1, MATR3, PMPCB, THAP7, LIN9, POLR2J, YPEL3, NFS1, ZNF655, SRRT, KIAA0020, SF3B1, SUMO1, STAT4, CIR1, HAND2, LEFTY2, MARS2, WDR12, HSD17B4, WIPF1, KDM3B, HSPA9, GTF3C3, PDK1, ACTB, BRD1, NF2, MAPK11, STAT1, CDC25C, PHAX, SDF2L1, NOP58, JAK2, HPGD, KIF20A 713 1820 12782 1.0047038515481712 1.0 0.9595473582658731 99.99823430867337 GOTERM_CC_FAT GO:0070013~intracellular organelle lumen 99 8.839285714285715 0.5660223311071098 MRPL40, MAEA, RNMT, DBF4, PDLIM3, AGXT, CTNNBL1, TOP1, WDR75, TFB2M, CCNA2, PRKAB2, RBL1, HDAC10, ZNF3, NVL, MAPK1, RCL1, MRPS18C, MED15, PRKRIP1, MAPK3, LRCH4, SMARCA2, CROT, HMGB2, LMNB1, PPIL2, AHCTF1, HSPE1, TAF6, MAFB, AK3, CDC23, SSB, NOP10, NOP14, PLK4, PPIG, CSRNP3, DLX5, GLS, HSPD1, PARP1, POP7, TAF1A, ZNF532, GTPBP10, DGCR14, SAP30, CDC45, MCM7, P4HA2, DGCR8, CASP8, DCAF17, BRD8, TFIP11, CTBP1, EXOSC9, LRPAP1, SIL1, RBM39, CTDP1, MATR3, PMPCB, THAP7, LIN9, POLR2J, YPEL3, NFS1, ZNF655, SRRT, KIAA0020, SF3B1, SUMO1, STAT4, CIR1, HAND2, WDR12, MARS2, HSD17B4, WIPF1, KDM3B, HSPA9, GTF3C3, PDK1, ACTB, BRD1, NF2, MAPK11, STAT1, CDC25C, PHAX, SDF2L1, NOP58, JAK2, HPGD, KIF20A 713 1779 12782 0.9976277704590015 1.0 0.9632948143628648 99.99936206607512 GOTERM_CC_FAT GO:0031974~membrane-enclosed lumen 103 9.196428571428573 0.5774239932202964 MRPL40, MAEA, RNMT, DBF4, PDLIM3, AGXT, CTNNBL1, TOP1, WDR75, TFB2M, CCNA2, PRKAB2, RBL1, F8, HDAC10, ZNF3, NVL, MAPK1, RCL1, VEGFC, MRPS18C, MED15, PRKRIP1, MAPK3, LRCH4, SMARCA2, CROT, HMGB2, LMNB1, PPIL2, AHCTF1, HSPE1, TAF6, MAFB, AK3, CDC23, SSB, NOP10, NOP14, PLK4, PPIG, CSRNP3, DLX5, GLS, HSPD1, PARP1, POP7, TAF1A, ZNF532, GTPBP10, DGCR14, ACN9, SAP30, CDC45, MCM7, P4HA2, DGCR8, CASP8, DCAF17, BRD8, TFIP11, CTBP1, EXOSC9, LRPAP1, SIL1, RBM39, CTDP1, MATR3, PMPCB, THAP7, LIN9, POLR2J, YPEL3, NFS1, ZNF655, SRRT, KIAA0020, SF3B1, SUMO1, STAT4, CIR1, HAND2, LEFTY2, MARS2, WDR12, HSD17B4, WIPF1, KDM3B, HSPA9, GTF3C3, PDK1, ACTB, BRD1, NF2, MAPK11, STAT1, CDC25C, PHAX, SDF2L1, NOP58, JAK2, HPGD, KIF20A 713 1856 12782 0.994875042317551 1.0 0.9612407579923826 99.99956440771307 GOTERM_CC_FAT GO:0031981~nuclear lumen 79 7.053571428571429 0.6501773487292639 MAEA, TAF1A, RNMT, ZNF532, DBF4, GTPBP10, PDLIM3, DGCR14, CTNNBL1, SAP30, WDR75, TOP1, CDC45, MCM7, DGCR8, CASP8, CCNA2, DCAF17, BRD8, TFIP11, CTBP1, EXOSC9, RBL1, PRKAB2, HDAC10, ZNF3, NVL, MAPK1, RCL1, MED15, MAPK3, PRKRIP1, LRCH4, RBM39, SMARCA2, CTDP1, MATR3, THAP7, HMGB2, LMNB1, LIN9, POLR2J, YPEL3, AHCTF1, ZNF655, SRRT, SF3B1, KIAA0020, SUMO1, STAT4, CIR1, HAND2, WDR12, KDM3B, WIPF1, GTF3C3, ACTB, BRD1, NF2, TAF6, MAFB, CDC23, SSB, MAPK11, CDC25C, STAT1, NOP10, NOP14, PHAX, PLK4, PPIG, CSRNP3, DLX5, NOP58, JAK2, PARP1, HPGD, POP7, KIF20A 713 1450 12782 0.9767161580500073 1.0 0.9682886583178953 99.99997094808016 GOTERM_CC_FAT GO:0005654~nucleoplasm 45 4.017857142857143 0.8028177436897755 THAP7, HMGB2, RNMT, TAF1A, LIN9, POLR2J, DBF4, AHCTF1, SRRT, SAP30, TOP1, SF3B1, SUMO1, CDC45, MCM7, CIR1, HAND2, WDR12, CCNA2, GTF3C3, BRD8, ACTB, TFIP11, BRD1, CTBP1, TAF6, MAFB, RBL1, PRKAB2, HDAC10, CDC23, MAPK11, CDC25C, NOP10, MAPK1, PHAX, PPIG, MED15, MAPK3, LRCH4, RBM39, PARP1, SMARCA2, CTDP1, KIF20A 713 882 12782 0.9146463634542175 1.0 0.9898067918350696 99.99999999214404 Annotation Cluster 193 Enrichment Score: 0.2165323586660905 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS ubl conjugation pathway 30 2.6785714285714284 0.38113086778533134 HECW2, ATG12, BTRC, RNF216, KLHL3, SUMO1, MAP1LC3C, UBE2D2, FBXW4, FBXO28, OTUD7A, FBXL13, NEDD4L, FBXO24, DCAF17, FBXL18, BRCC3, UFSP2, UFD1L, SOCS6, CDC23, UBR3, MALT1, UBE2L3, MARCH3, FEM1C, UHRF2, TRIM36, FBXO15, ASB5 1027 509 19235 1.1038885264843337 1.0 0.8961812504867351 99.91017293779376 GOTERM_BP_FAT GO:0006508~proteolysis 60 5.357142857142857 0.5152078673168088 HECW2, CNDP1, CNDP2, BTRC, RNPEPL1, RNF216, KLHL3, MAP1LC3C, USP53, CASP8, FBXO28, FBXL13, FBXO24, FBXL18, IHH, F11, BRCC3, UFD1L, SOCS6, UBR3, OSGEPL1, CAPN10, UHRF2, MAD2L1, AQPEP, PSEN2, FBXO15, ASB5, PMPCB, ERMP1, ADAMTS19, ATG12, TFR2, SUMO1, PEG10, UBE2D2, KLKB1, FBXW4, OTUD7A, SCG5, NEDD4L, HGFAC, FBXO8, CFLAR, UFSP2, ADAM29, SEC11C, CAPN8, CDC23, MALT1, UBE2L3, CAPN2, AFG3L2, DNPEP, MARCH3, FEM1C, CASP10, PSMC2, SPCS3, ADAM22 751 1054 13528 1.0254259343013867 1.0 0.9949604382919648 99.99975452402332 GOTERM_BP_FAT GO:0051603~proteolysis involved in cellular protein catabolic process 34 3.0357142857142856 0.5458221704229812 HECW2, ATG12, BTRC, RNF216, KLHL3, SUMO1, USP53, MAP1LC3C, UBE2D2, FBXW4, CASP8, FBXO28, OTUD7A, FBXL13, FBXO24, NEDD4L, FBXO8, FBXL18, UFSP2, BRCC3, UFD1L, SOCS6, UBR3, CDC23, MALT1, UBE2L3, MARCH3, FEM1C, UHRF2, MAD2L1, PSMC2, PSEN2, FBXO15, ASB5 751 600 13528 1.0207545494895693 1.0 0.9951557401238104 99.99992333782865 GOTERM_BP_FAT GO:0044257~cellular protein catabolic process 34 3.0357142857142856 0.5577779395081769 HECW2, ATG12, BTRC, RNF216, KLHL3, SUMO1, USP53, MAP1LC3C, UBE2D2, FBXW4, CASP8, FBXO28, OTUD7A, FBXL13, FBXO24, NEDD4L, FBXO8, FBXL18, UFSP2, BRCC3, UFD1L, SOCS6, UBR3, CDC23, MALT1, UBE2L3, MARCH3, FEM1C, UHRF2, MAD2L1, PSMC2, PSEN2, FBXO15, ASB5 751 603 13528 1.0156761686463378 1.0 0.9953857392066288 99.99995236960513 GOTERM_BP_FAT GO:0030163~protein catabolic process 35 3.125 0.5607663643824494 HECW2, ATG12, BTRC, RNF216, KLHL3, SUMO1, USP53, MAP1LC3C, UBE2D2, FBXW4, CASP8, FBXO28, OTUD7A, FBXL13, FBXO24, NEDD4L, FBXO8, FBXL18, UFSP2, BRCC3, UFD1L, SOCS6, UBR3, CDC23, MALT1, AFG3L2, UBE2L3, MARCH3, FEM1C, UHRF2, MAD2L1, PSMC2, PSEN2, FBXO15, ASB5 751 622 13528 1.0136110052620086 1.0 0.9954139987339061 99.9999577967521 GOTERM_BP_FAT GO:0043632~modification-dependent macromolecule catabolic process 32 2.857142857142857 0.5880534224331696 HECW2, ATG12, BTRC, RNF216, KLHL3, SUMO1, USP53, MAP1LC3C, UBE2D2, FBXW4, FBXO28, OTUD7A, FBXL13, NEDD4L, FBXO24, FBXO8, FBXL18, BRCC3, UFSP2, UFD1L, SOCS6, UBR3, CDC23, MALT1, UBE2L3, MARCH3, FEM1C, UHRF2, MAD2L1, PSMC2, FBXO15, ASB5 751 574 13528 1.0042266525004988 1.0 0.9961783467442735 99.99998656024312 GOTERM_BP_FAT GO:0019941~modification-dependent protein catabolic process 32 2.857142857142857 0.5880534224331696 HECW2, ATG12, BTRC, RNF216, KLHL3, SUMO1, USP53, MAP1LC3C, UBE2D2, FBXW4, FBXO28, OTUD7A, FBXL13, NEDD4L, FBXO24, FBXO8, FBXL18, BRCC3, UFSP2, UFD1L, SOCS6, UBR3, CDC23, MALT1, UBE2L3, MARCH3, FEM1C, UHRF2, MAD2L1, PSMC2, FBXO15, ASB5 751 574 13528 1.0042266525004988 1.0 0.9961783467442735 99.99998656024312 GOTERM_BP_FAT GO:0006511~ubiquitin-dependent protein catabolic process 12 1.0714285714285714 0.7922986914641563 USP53, UBE2D2, MAD2L1, UHRF2, UFD1L, PSMC2, BTRC, FBXW4, CDC23, UBR3, UBE2L3, FBXO8 751 242 13528 0.8932222601269932 1.0 0.9994453937834781 99.99999999993355 GOTERM_BP_FAT GO:0044265~cellular macromolecule catabolic process 36 3.214285714285714 0.8285272143335219 HECW2, ATG12, BTRC, RNF216, KLHL3, SUMO1, USP53, MAP1LC3C, UBE2D2, FBXW4, CASP8, FBXO28, HNRNPD, OTUD7A, FBXL13, FBXO24, NEDD4L, FBXO8, FBXL18, UFSP2, BRCC3, UFD1L, SOCS6, CIDEA, UBR3, CDC23, MALT1, UBE2L3, MARCH3, FEM1C, UHRF2, MAD2L1, PSMC2, PSEN2, FBXO15, ASB5 751 725 13528 0.8944542908306167 1.0 0.9996851589803439 99.99999999999783 GOTERM_BP_FAT GO:0009057~macromolecule catabolic process 37 3.303571428571429 0.8980407857303043 HECW2, ATG12, BTRC, RNF216, KLHL3, SUMO1, USP53, MAP1LC3C, UBE2D2, FBXW4, CASP8, FBXO28, HNRNPD, OTUD7A, FBXL13, FBXO24, NEDD4L, FBXO8, FBXL18, UFSP2, BRCC3, UFD1L, SOCS6, CIDEA, UBR3, CDC23, MALT1, AFG3L2, UBE2L3, MARCH3, FEM1C, UHRF2, MAD2L1, PSMC2, PSEN2, FBXO15, ASB5 751 781 13528 0.8533837086189817 1.0 0.999943256896966 100.0 Annotation Cluster 194 Enrichment Score: 0.21651779462940796 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007613~memory 4 0.35714285714285715 0.3683658235370726 PSEN2, TAC1, CHRNA7, VLDLR 751 39 13528 1.8475195465874563 1.0 0.9885327863658936 99.9724504267569 GOTERM_BP_FAT GO:0001666~response to hypoxia 7 0.625 0.7597977443399558 BCL2, PSEN2, PDE5A, CHRNA7, CAPN2, VLDLR, EPO 751 134 13528 0.9409940974223425 1.0 0.9991301338862217 99.999999999111 GOTERM_BP_FAT GO:0070482~response to oxygen levels 7 0.625 0.8006989998761329 BCL2, PSEN2, PDE5A, CHRNA7, CAPN2, VLDLR, EPO 751 141 13528 0.894278078401375 1.0 0.9995006896003722 99.9999999999682 Annotation Cluster 195 Enrichment Score: 0.21529380285108704 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004435~phosphoinositide phospholipase C activity 3 0.26785714285714285 0.4101436160593942 PLCL1, CHRM5, PLCG1 725 25 12983 2.1489103448275864 1.0 0.995696972253086 99.97221734913879 GOTERM_MF_FAT GO:0004629~phospholipase C activity 3 0.26785714285714285 0.5222947916904672 PLCL1, CHRM5, PLCG1 725 31 12983 1.732992213570634 1.0 0.9982385983022733 99.99894544356643 GOTERM_MF_FAT GO:0016298~lipase activity 6 0.5357142857142857 0.6621144461288296 PLCL1, CHRM5, NAPEPLD, PLCG1, AOAH, DAGLB 725 100 12983 1.0744551724137932 1.0 0.9993932387634933 99.99999510010599 GOTERM_MF_FAT GO:0008081~phosphoric diester hydrolase activity 5 0.4464285714285714 0.6963401049572093 PLCL1, CHRM5, PLCG1, PDE5A, GDPD3 725 84 12983 1.065927750410509 1.0 0.9993769837913384 99.99999906524548 GOTERM_MF_FAT GO:0004620~phospholipase activity 4 0.35714285714285715 0.8490335705297803 PLCL1, CHRM5, NAPEPLD, PLCG1 725 83 12983 0.8630162027420024 1.0 0.9999145053743999 99.9999999999817 Annotation Cluster 196 Enrichment Score: 0.21161789129493605 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051248~negative regulation of protein metabolic process 12 1.0714285714285714 0.4643876076585004 MAD2L1, EIF2AK1, NF2, PAIP2, PSMC2, ITGAV, PSEN2, SERPINB10, CDC23, SERPINB12, SRP9, IL2 751 187 13528 1.155934689576109 1.0 0.9930538416819806 99.99854643531482 GOTERM_BP_FAT GO:0032269~negative regulation of cellular protein metabolic process 11 0.9821428571428571 0.5437915700405135 MAD2L1, EIF2AK1, NF2, PAIP2, PSMC2, ITGAV, PSEN2, SERPINB10, CDC23, SRP9, IL2 751 180 13528 1.1008137298416925 1.0 0.9950720165192074 99.99991698706738 GOTERM_BP_FAT GO:0032268~regulation of cellular protein metabolic process 25 2.232142857142857 0.7082798508161945 CSF2, ZAK, BTRC, BMPR2, ITGAV, BCL2, KLKB1, SERPINB10, RAPGEF4, EPO, IL3, NF2, PAIP2, CDC23, ETF1, BOLL, VEGFC, MAPK1, MAD2L1, EIF2AK1, PSMC2, PSEN2, JAK2, SRP9, IL2 751 474 13528 0.9500693870900684 1.0 0.998505658527549 99.9999999715235 GOTERM_BP_FAT GO:0031400~negative regulation of protein modification process 6 0.5357142857142857 0.7961785169486193 MAD2L1, NF2, PSMC2, PSEN2, CDC23, IL2 751 119 13528 0.9082343989526569 1.0 0.9994660172324321 99.99999999995254 Annotation Cluster 197 Enrichment Score: 0.21147328854139424 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042113~B cell activation 6 0.5357142857142857 0.4140318586526262 EXO1, BCL2, SP3, MALT1, HSPD1, NHEJ1 751 76 13528 1.4221038615179762 1.0 0.9914526348355741 99.99277813923139 GOTERM_BP_FAT GO:0046651~lymphocyte proliferation 3 0.26785714285714285 0.6847008045246621 BCL2, MALT1, HSPD1 751 42 13528 1.2866653985162642 1.0 0.998232089272891 99.99999988604483 GOTERM_BP_FAT GO:0070661~leukocyte proliferation 3 0.26785714285714285 0.7092284094259473 BCL2, MALT1, HSPD1 751 44 13528 1.2281806076746156 1.0 0.9985127412245044 99.999999973131 GOTERM_BP_FAT GO:0032943~mononuclear cell proliferation 3 0.26785714285714285 0.7092284094259473 BCL2, MALT1, HSPD1 751 44 13528 1.2281806076746156 1.0 0.9985127412245044 99.999999973131 Annotation Cluster 198 Enrichment Score: 0.21063470479375218 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007611~learning or memory 8 0.7142857142857143 0.4191391020306839 EGR1, HTT, PSEN2, ABI2, TAC1, CHRNA7, COMT, VLDLR 751 111 13528 1.2982569786830773 1.0 0.9918448207251498 99.99382239366066 GOTERM_BP_FAT GO:0044057~regulation of system process 18 1.607142857142857 0.5491575701099027 CPLX4, SRI, EGR1, ACHE, SNCAIP, HTT, BMPR2, TAC1, MSTN, INHA, VGF, MYL9, DES, PSEN2, JAK2, CALCRL, KCNG2, IL2 751 309 13528 1.0493193541297687 1.0 0.9952068342748905 99.99993278448274 GOTERM_BP_FAT GO:0050804~regulation of synaptic transmission 8 0.7142857142857143 0.6343038722423486 CPLX4, EGR1, ACHE, SNCAIP, HTT, PSEN2, TAC1, VGF 751 136 13528 1.0596067987781 1.0 0.9972920853180798 99.9999983943632 GOTERM_BP_FAT GO:0048167~regulation of synaptic plasticity 4 0.35714285714285715 0.6966201803615009 EGR1, HTT, PSEN2, VGF 751 64 13528 1.125832223701731 1.0 0.9984147694424113 99.99999994270132 GOTERM_BP_FAT GO:0051969~regulation of transmission of nerve impulse 8 0.7142857142857143 0.713161762418593 CPLX4, EGR1, ACHE, SNCAIP, HTT, PSEN2, TAC1, VGF 751 147 13528 0.9803164941076298 1.0 0.9985449882046605 99.99999997892714 GOTERM_BP_FAT GO:0031644~regulation of neurological system process 8 0.7142857142857143 0.7510263148937738 CPLX4, EGR1, ACHE, SNCAIP, HTT, PSEN2, TAC1, VGF 751 153 13528 0.9418727100249777 1.0 0.999023916339162 99.99999999831424 Annotation Cluster 199 Enrichment Score: 0.20489583968109562 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR002347:Glucose/ribitol dehydrogenase 4 0.35714285714285715 0.5658711502001894 DHRS9, KDSR, HSD17B4, HPGD 920 53 16659 1.3666119770303526 1.0 0.9999642555791715 99.99988090259139 UP_SEQ_FEATURE nucleotide phosphate-binding region:NAD 5 0.4464285714285714 0.5857148980470547 CTBP1, ALDH7A1, DHRS9, HSD17B4, HPGD 1024 76 19113 1.227963096217105 1.0 0.9999999394990379 99.99998327405109 INTERPRO IPR016040:NAD(P)-binding domain 9 0.8035714285714285 0.5903387811892065 SCCPDH, STEAP4, CTBP1, PYCR2, DHRS9, KDSR, HSD17B4, STEAP2, HPGD 920 150 16659 1.0864565217391307 1.0 0.9999713995084606 99.99995386378244 INTERPRO IPR002198:Short-chain dehydrogenase/reductase SDR 4 0.35714285714285715 0.6391358908345048 DHRS9, KDSR, HSD17B4, HPGD 920 59 16659 1.2276344878408254 1.0 0.9999869412566137 99.99999419780575 UP_SEQ_FEATURE binding site:NAD 3 0.26785714285714285 0.7558270967653514 CTBP1, DHRS9, HSD17B4 1024 50 19113 1.11990234375 1.0 0.9999999994409786 99.99999999856202 Annotation Cluster 200 Enrichment Score: 0.19932559780604253 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000165~MAPKKK cascade 11 0.9821428571428571 0.5721604088776562 MAPK1, CRKL, FGFR3, ZAK, TAOK2, MAPK8IP2, CHRNA7, ITPKB, JAK2, STRADB, SHANK3 751 184 13528 1.0768829965842646 1.0 0.9957182298491553 99.99997359427539 GOTERM_BP_FAT GO:0007254~JNK cascade 4 0.35714285714285715 0.6426366141854238 CRKL, ZAK, MAPK8IP2, STRADB 751 59 13528 1.2212417341849287 1.0 0.9975113123073691 99.99999893572515 GOTERM_BP_FAT GO:0031098~stress-activated protein kinase signaling pathway 4 0.35714285714285715 0.6863409912708732 CRKL, ZAK, MAPK8IP2, STRADB 751 63 13528 1.1437025764589015 1.0 0.9982381336236708 99.99999989617008 Annotation Cluster 201 Enrichment Score: 0.19676535479147642 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR018359:Bromodomain, conserved site 3 0.26785714285714285 0.5980866463844321 BRD1, SMARCA2, BRD8 920 36 16659 1.5089673913043478 1.0 0.9999724210347241 99.99996623395975 SP_PIR_KEYWORDS bromodomain 3 0.26785714285714285 0.6232523738886278 BRD1, SMARCA2, BRD8 1027 39 19235 1.4407160512321173 1.0 0.9606988183745331 99.99993656462844 INTERPRO IPR001487:Bromodomain 3 0.26785714285714285 0.655688075984342 BRD1, SMARCA2, BRD8 920 40 16659 1.358070652173913 1.0 0.999987499717425 99.99999730700041 SMART SM00297:BROMO 3 0.26785714285714285 0.6680565827029752 BRD1, SMARCA2, BRD8 513 40 9079 1.3273391812865498 1.0 0.9980678996593237 99.99995037898262 Annotation Cluster 202 Enrichment Score: 0.19557810710103585 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0046320~regulation of fatty acid oxidation 3 0.26785714285714285 0.46488239648518154 CPT1B, CHKB, PRKAB2, STRADB 751 28 13528 1.9299980977743958 1.0 0.9930054318474782 99.99857020628914 GOTERM_BP_FAT GO:0010565~regulation of cellular ketone metabolic process 4 0.35714285714285715 0.6192335113012027 CPT1B, CHKB, PRKAB2, STRADB, COMT 751 57 13528 1.264092321349312 1.0 0.9968880761174566 99.99999669973766 GOTERM_BP_FAT GO:0019216~regulation of lipid metabolic process 6 0.5357142857142857 0.7509552631389924 CPT1B, CHKB, PRKAB2, RBL1, RAC1, CIDEA, STRADB 751 112 13528 0.9649990488871979 1.0 0.9990347006618536 99.99999999830564 GOTERM_BP_FAT GO:0019217~regulation of fatty acid metabolic process 3 0.26785714285714285 0.7636176425377176 CPT1B, CHKB, PRKAB2, STRADB 751 49 13528 1.1028560558710836 1.0 0.9991756968150374 99.99999999933213 Annotation Cluster 203 Enrichment Score: 0.19544289671510573 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060249~anatomical structure homeostasis 7 0.625 0.538968067560392 ALDOA, MUC3A, BCL2, RAC1, CHRNA1, PARP1, ADD1 751 106 13528 1.1895585759867346 1.0 0.9952350033128735 99.99989985300292 GOTERM_BP_FAT GO:0001894~tissue homeostasis 4 0.35714285714285715 0.6863409912708732 MUC3A, BCL2, RAC1, ADD1 751 63 13528 1.1437025764589015 1.0 0.9982381336236708 99.99999989617008 GOTERM_BP_FAT GO:0048871~multicellular organismal homeostasis 5 0.4464285714285714 0.7007584399065303 MUC3A, BCL2, RAC1, CIDEA, ADD1 751 85 13528 1.0596067987780997 1.0 0.9984321822609613 99.99999995515364 Annotation Cluster 204 Enrichment Score: 0.1929291010708886 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051168~nuclear export 5 0.4464285714285714 0.42765614512823863 PHAX, MALT1, THOC5, STRADB, HSPA9 751 60 13528 1.501109631602308 1.0 0.9921454428994209 99.99525355596116 GOTERM_BP_FAT GO:0006913~nucleocytoplasmic transport 10 0.8928571428571428 0.5002494924263514 PHAX, MAPK1, MCM3AP, HTT, NOP58, MALT1, JAK2, THOC5, STRADB, HSPA9 751 156 13528 1.15469971661716 1.0 0.9944391720684984 99.99957784853304 GOTERM_BP_FAT GO:0051169~nuclear transport 10 0.8928571428571428 0.5157814481395792 PHAX, MAPK1, MCM3AP, HTT, NOP58, MALT1, JAK2, THOC5, STRADB, HSPA9 751 158 13528 1.140083264508082 1.0 0.9948625399296182 99.99975965435041 GOTERM_BP_FAT GO:0006605~protein targeting 13 1.1607142857142858 0.5330419998202042 MCM3AP, TAOK2, HTT, HPS4, STRADB, AGXT, MAPK1, TRAK2, PEX1, NOP58, JAK2, SRP9, HSPA9 751 215 13528 1.0891772210695816 1.0 0.9951308118476085 99.9998742238159 GOTERM_BP_FAT GO:0006606~protein import into nucleus 5 0.4464285714285714 0.7094626566160288 MAPK1, MCM3AP, HTT, NOP58, JAK2 751 86 13528 1.0472857894899823 1.0 0.9985005531395813 99.99999997351458 GOTERM_BP_FAT GO:0051170~nuclear import 5 0.4464285714285714 0.7263138210376722 MAPK1, MCM3AP, HTT, NOP58, JAK2 751 88 13528 1.0234838397288464 1.0 0.9986604064625789 99.99999999087883 GOTERM_BP_FAT GO:0034504~protein localization in nucleus 5 0.4464285714285714 0.772469466706004 MAPK1, MCM3AP, HTT, NOP58, JAK2 751 94 13528 0.9581550840014731 1.0 0.9992899017275296 99.99999999966195 GOTERM_BP_FAT GO:0017038~protein import 6 0.5357142857142857 0.8584029280037975 MAPK1, MCM3AP, PEX1, HTT, NOP58, JAK2 751 131 13528 0.8250373547737876 1.0 0.999837080153123 99.99999999999993 GOTERM_BP_FAT GO:0033365~protein localization in organelle 6 0.5357142857142857 0.9130681803943548 MAPK1, MCM3AP, HTT, NOP58, JAK2, SRP9 751 146 13528 0.7402732429819602 1.0 0.9999668948422128 100.0 Annotation Cluster 205 Enrichment Score: 0.1922626155541614 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044429~mitochondrial part 35 3.125 0.46681222171590536 NDUFB3, MRPL40, CHKB, NFS1, AGXT, ATP5G3, ACN9, FIS1, TMEM173, BCL2, CASP8, MARS2, TFB2M, SLC25A1, HSPE1, SCO2, ACSL6, SLC25A40, HSPA9, PDK1, CPT1B, ATP5J2, AIFM3, AK3, CIDEA, CYB5A, AFG3L2, ABCB6, SLC25A12, SLC25A31, MRPS18C, GLS, NDUFV2, NIPSNAP1, HSPD1, PMPCB 713 595 12782 1.0545334543354508 1.0 0.9591303078359068 99.98780747374919 GOTERM_CC_FAT GO:0005740~mitochondrial envelope 24 2.142857142857143 0.5606089258749296 NDUFB3, CHKB, ATP5G3, ACN9, FIS1, TMEM173, BCL2, CASP8, SLC25A1, SLC25A40, ACSL6, SCO2, CPT1B, ATP5J2, AIFM3, CIDEA, CYB5A, AFG3L2, ABCB6, SLC25A12, SLC25A31, NDUFV2, NIPSNAP1, HSPD1, PMPCB 713 419 12782 1.0268488051762863 1.0 0.9634845882540706 99.9992380469815 SP_PIR_KEYWORDS mitochondrion 44 3.9285714285714284 0.6089586248466974 NDUFB3, MRPL40, FTMT, CHKB, NFS1, ROMO1, PMAIP1, AGXT, ATP5G3, ACN9, GLDC, FIS1, TMEM173, BCL2, MARS2, TFB2M, MTCP1, SLC25A1, HSPE1, SCO2, ACSL6, SLC25A40, HSPA9, ENOSF1, PDK1, AADAT, CPT1B, ATP5J2, AIFM3, AK3, AFG3L2, ABCB6, SLC25A12, COQ2, SLC25A31, MRPS18C, MAPK12, GLS, NDUFV2, C2ORF47, COQ10B, TXNRD2, HSPD1, HIBCH, PMPCB 1027 832 19235 0.9904922852220808 1.0 0.9611632795978208 99.99989066711069 GOTERM_CC_FAT GO:0031966~mitochondrial membrane 22 1.9642857142857142 0.6158499271455236 NDUFB3, CPT1B, ATP5J2, AIFM3, CHKB, CYB5A, AFG3L2, ABCB6, ATP5G3, SLC25A12, FIS1, TMEM173, SLC25A31, BCL2, NIPSNAP1, NDUFV2, CASP8, SLC25A1, HSPD1, SCO2, SLC25A40, PMPCB, ACSL6 713 394 12782 1.0010038373641081 1.0 0.9657123058621184 99.9998888915686 GOTERM_CC_FAT GO:0031967~organelle envelope 34 3.0357142857142856 0.6347264560419268 NDUFB3, THAP7, LMNB1, CHKB, AHCTF1, ATP5G3, ACN9, FIS1, SUMO1, TMEM173, SEH1L, BCL2, CASP8, SLC25A1, LBR, SCO2, ACSL6, SLC25A40, CPT1B, ATP5J2, AIFM3, CIDEA, CYB5A, AFG3L2, ABCB6, SLC25A12, SLC25A31, MAD2L1, NDUFV2, NIPSNAP1, HSPD1, PARP1, MATR3, PMPCB, MVP 713 620 12782 0.9830973171062751 1.0 0.9658847461591613 99.99994602906514 GOTERM_CC_FAT GO:0031975~envelope 34 3.0357142857142856 0.6421439439208823 NDUFB3, THAP7, LMNB1, CHKB, AHCTF1, ATP5G3, ACN9, FIS1, SUMO1, TMEM173, SEH1L, BCL2, CASP8, SLC25A1, LBR, SCO2, ACSL6, SLC25A40, CPT1B, ATP5J2, AIFM3, CIDEA, CYB5A, AFG3L2, ABCB6, SLC25A12, SLC25A31, MAD2L1, NDUFV2, NIPSNAP1, HSPD1, PARP1, MATR3, PMPCB, MVP 713 622 12782 0.9799362324853547 1.0 0.966613609031978 99.99995977661722 GOTERM_CC_FAT GO:0005739~mitochondrion 58 5.178571428571429 0.7081788181064719 MRPL40, FTMT, ROMO1, ZKSCAN1, PMAIP1, AGXT, ACN9, GLDC, TMEM173, CASP8, TFB2M, SLC25A1, BRD8, FUNDC2, AADAT, AIFM3, CYB5A, ALDH7A1, COQ2, SLC25A31, MRPS18C, TXNRD2, PMPCB, NDUFB3, NAPG, CHKB, ACP6, NFS1, ATP5G3, FIS1, BCL2, TGM2, MARS2, NEFH, MTCP1, HSPE1, HSD17B4, GAD1, SLC25A40, ACSL6, SCO2, ENOSF1, HSPA9, PDK1, CPT1B, ATP5J2, AK3, CIDEA, AFG3L2, ABCB6, SLC25A12, MAPK12, GLS, NDUFV2, C2ORF47, NIPSNAP1, COQ10B, HSPD1, HIBCH 713 1087 12782 0.9565501250917705 1.0 0.9805427144247952 99.99999783763343 GOTERM_CC_FAT GO:0019866~organelle inner membrane 17 1.5178571428571428 0.7486027858601358 NDUFB3, ATP5J2, AIFM3, LMNB1, AFG3L2, ATP5G3, SLC25A12, SLC25A31, NIPSNAP1, NDUFV2, SLC25A1, HSPD1, LBR, MATR3, SLC25A40, PMPCB, SCO2 713 329 12782 0.9263227000089522 1.0 0.9849181896592634 99.99999974476088 GOTERM_CC_FAT GO:0005743~mitochondrial inner membrane 14 1.25 0.8773203241001339 NDUFB3, ATP5J2, AIFM3, AFG3L2, ATP5G3, SLC25A12, SLC25A31, NIPSNAP1, NDUFV2, SLC25A1, HSPD1, SLC25A40, PMPCB, SCO2 713 306 12782 0.8201926867053507 1.0 0.9962984622336506 99.99999999999125 Annotation Cluster 206 Enrichment Score: 0.19123964592132045 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044429~mitochondrial part 35 3.125 0.46681222171590536 NDUFB3, MRPL40, CHKB, NFS1, AGXT, ATP5G3, ACN9, FIS1, TMEM173, BCL2, CASP8, MARS2, TFB2M, SLC25A1, HSPE1, SCO2, ACSL6, SLC25A40, HSPA9, PDK1, CPT1B, ATP5J2, AIFM3, AK3, CIDEA, CYB5A, AFG3L2, ABCB6, SLC25A12, SLC25A31, MRPS18C, GLS, NDUFV2, NIPSNAP1, HSPD1, PMPCB 713 595 12782 1.0545334543354508 1.0 0.9591303078359068 99.98780747374919 SP_PIR_KEYWORDS mitochondrion 44 3.9285714285714284 0.6089586248466974 NDUFB3, MRPL40, FTMT, CHKB, NFS1, ROMO1, PMAIP1, AGXT, ATP5G3, ACN9, GLDC, FIS1, TMEM173, BCL2, MARS2, TFB2M, MTCP1, SLC25A1, HSPE1, SCO2, ACSL6, SLC25A40, HSPA9, ENOSF1, PDK1, AADAT, CPT1B, ATP5J2, AIFM3, AK3, AFG3L2, ABCB6, SLC25A12, COQ2, SLC25A31, MRPS18C, MAPK12, GLS, NDUFV2, C2ORF47, COQ10B, TXNRD2, HSPD1, HIBCH, PMPCB 1027 832 19235 0.9904922852220808 1.0 0.9611632795978208 99.99989066711069 GOTERM_CC_FAT GO:0005759~mitochondrial matrix 13 1.1607142857142858 0.6164438147976937 PDK1, MRPL40, NFS1, AK3, AGXT, MRPS18C, GLS, TFB2M, MARS2, HSPE1, HSPD1, PMPCB, HSPA9 713 227 12782 1.026660323383853 1.0 0.963338517956308 99.9998913279088 GOTERM_CC_FAT GO:0031980~mitochondrial lumen 13 1.1607142857142858 0.6164438147976937 PDK1, MRPL40, NFS1, AK3, AGXT, MRPS18C, GLS, TFB2M, MARS2, HSPE1, HSPD1, PMPCB, HSPA9 713 227 12782 1.026660323383853 1.0 0.963338517956308 99.9998913279088 GOTERM_CC_FAT GO:0005739~mitochondrion 58 5.178571428571429 0.7081788181064719 MRPL40, FTMT, ROMO1, ZKSCAN1, PMAIP1, AGXT, ACN9, GLDC, TMEM173, CASP8, TFB2M, SLC25A1, BRD8, FUNDC2, AADAT, AIFM3, CYB5A, ALDH7A1, COQ2, SLC25A31, MRPS18C, TXNRD2, PMPCB, NDUFB3, NAPG, CHKB, ACP6, NFS1, ATP5G3, FIS1, BCL2, TGM2, MARS2, NEFH, MTCP1, HSPE1, HSD17B4, GAD1, SLC25A40, ACSL6, SCO2, ENOSF1, HSPA9, PDK1, CPT1B, ATP5J2, AK3, CIDEA, AFG3L2, ABCB6, SLC25A12, MAPK12, GLS, NDUFV2, C2ORF47, NIPSNAP1, COQ10B, HSPD1, HIBCH 713 1087 12782 0.9565501250917705 1.0 0.9805427144247952 99.99999783763343 UP_SEQ_FEATURE transit peptide:Mitochondrion 23 2.0535714285714284 0.7623027086892744 AADAT, MRPL40, PDK1, FTMT, NFS1, ATP5G3, ACN9, GLDC, COQ2, MRPS18C, GLS, C2ORF47, NDUFV2, MARS2, TXNRD2, TFB2M, COQ10B, SLC25A1, HIBCH, HSPD1, SCO2, PMPCB, HSPA9 1024 467 19113 0.9192631658190578 1.0 0.9999999995213278 99.99999999910659 SP_PIR_KEYWORDS transit peptide 23 2.0535714285714284 0.7862036946563296 AADAT, MRPL40, PDK1, FTMT, NFS1, ATP5G3, ACN9, GLDC, COQ2, MRPS18C, GLS, C2ORF47, NDUFV2, MARS2, TXNRD2, TFB2M, COQ10B, SLC25A1, HIBCH, HSPD1, SCO2, PMPCB, HSPA9 1027 476 19235 0.9049876036100906 1.0 0.9836166603188057 99.99999998395461 Annotation Cluster 207 Enrichment Score: 0.19059251349827294 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051606~detection of stimulus 8 0.7142857142857143 0.4828415080925045 GNGT1, TRPC3, SLC12A2, TLR3, TAC1, LBP, PARP1, NLRP3 751 118 13528 1.2212417341849287 1.0 0.9937376561839713 99.99922237390454 GOTERM_BP_FAT GO:0009582~detection of abiotic stimulus 4 0.35714285714285715 0.7066422567355238 GNGT1, TRPC3, SLC12A2, TAC1 751 65 13528 1.1085117279524737 1.0 0.9984986171237576 99.99999996853262 GOTERM_BP_FAT GO:0009581~detection of external stimulus 4 0.35714285714285715 0.7856303588420848 GNGT1, TRPC3, SLC12A2, TLR3 751 74 13528 0.9736927340123079 1.0 0.9994182300539859 99.99999999988324 Annotation Cluster 208 Enrichment Score: 0.1890974007317854 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005643~nuclear pore 6 0.5357142857142857 0.45131818149396014 SUMO1, MAD2L1, SEH1L, AHCTF1, LBR, MVP 713 79 12782 1.3615495233191897 1.0 0.9557259997240466 99.9816190091323 GOTERM_CC_FAT GO:0046930~pore complex 6 0.5357142857142857 0.6160226470215248 SUMO1, MAD2L1, SEH1L, AHCTF1, LBR, MVP 713 95 12782 1.1322359193917473 1.0 0.9640634185653101 99.9998896053161 SP_PIR_KEYWORDS nuclear pore complex 3 0.26785714285714285 0.6370869092752962 SEH1L, AHCTF1, MVP 1027 40 19235 1.4046981499513145 1.0 0.961742450295605 99.99996328821933 GOTERM_CC_FAT GO:0005635~nuclear envelope 11 0.9821428571428571 0.7120951231506324 THAP7, SUMO1, MAD2L1, LMNB1, SEH1L, BCL2, AHCTF1, PARP1, LBR, MATR3, MVP 713 205 12782 0.9619402729791674 1.0 0.9803698606942863 99.99999821827062 SP_PIR_KEYWORDS translocation 4 0.35714285714285715 0.76260508592015 SEH1L, SIL1, AHCTF1, MVP 1027 74 19235 1.0123950630279746 1.0 0.9806628708371828 99.99999992585387 SP_PIR_KEYWORDS mRNA transport 4 0.35714285714285715 0.76260508592015 SEH1L, AHCTF1, THOC5, MVP 1027 74 19235 1.0123950630279746 1.0 0.9806628708371828 99.99999992585387 Annotation Cluster 209 Enrichment Score: 0.18672900411611426 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR017974:Claudin, conserved site 3 0.26785714285714285 0.3239122272686463 CLDN5, CLDN12, CLDN15 920 21 16659 2.5868012422360245 1.0 0.9990368291572153 99.83368047759556 GOTERM_BP_FAT GO:0016338~calcium-independent cell-cell adhesion 3 0.26785714285714285 0.34673430736531674 CLDN5, CLDN12, CLDN15 751 22 13528 2.456361215349231 1.0 0.989143614306072 99.94976282593954 GOTERM_CC_FAT GO:0005923~tight junction 4 0.35714285714285715 0.7806278755070197 VAPA, CLDN5, CLDN12, CLDN15 713 73 12782 0.9823051355453515 1.0 0.9882115039994475 99.99999996378484 GOTERM_CC_FAT GO:0070160~occluding junction 4 0.35714285714285715 0.7806278755070197 VAPA, CLDN5, CLDN12, CLDN15 713 73 12782 0.9823051355453515 1.0 0.9882115039994475 99.99999996378484 SP_PIR_KEYWORDS Tight junction 3 0.26785714285714285 0.8437916577413527 CLDN5, CLDN12, CLDN15 1027 61 19235 0.9211135409516815 1.0 0.9911021668438377 99.99999999983675 GOTERM_CC_FAT GO:0043296~apical junction complex 4 0.35714285714285715 0.9193632103972187 VAPA, CLDN5, CLDN12, CLDN15 713 99 12782 0.7243260090384914 1.0 0.9983945938653757 99.99999999999997 GOTERM_CC_FAT GO:0016327~apicolateral plasma membrane 4 0.35714285714285715 0.9286720072562433 VAPA, CLDN5, CLDN12, CLDN15 713 102 12782 0.7030223028903005 1.0 0.9986961363015125 100.0 Annotation Cluster 210 Enrichment Score: 0.18164477036373367 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016049~cell growth 6 0.5357142857142857 0.2487983966950528 FGFR3, BCL2, LEFTY2, NOP58, ODF3B, LEFTY1 751 61 13528 1.771801532383052 1.0 0.9829732684412159 99.39273724792704 GOTERM_BP_FAT GO:0032535~regulation of cellular component size 16 1.4285714285714286 0.5408771876723972 ALS2, FGFR3, GREM1, LEFTY1, ARPC1A, ARPC1B, NDRG3, MAPT, BCL2, RAC1, LEFTY2, NOP58, ODF3B, DNAJC2, ADD1, IL2 751 271 13528 1.063516786965473 1.0 0.9950519009879717 99.99990699932269 GOTERM_BP_FAT GO:0040007~growth 11 0.9821428571428571 0.56513639160668 FGFR3, BCL2, LEFTY2, PSEN2, SERPINE1, MSTN, NOP58, ODF3B, CHRNA1, ADD1, LEFTY1 751 183 13528 1.0827676031229763 1.0 0.9954789690606225 99.99996469216758 GOTERM_BP_FAT GO:0008361~regulation of cell size 11 0.9821428571428571 0.712121958617496 FGFR3, NDRG3, BCL2, MAPT, LEFTY2, NOP58, ODF3B, GREM1, DNAJC2, LEFTY1, IL2 751 206 13528 0.9618760746189546 1.0 0.9985353996372541 99.99999997752185 GOTERM_BP_FAT GO:0045926~negative regulation of growth 5 0.4464285714285714 0.8658298636332981 NDRG3, BCL2, MSTN, GREM1, DNAJC2 751 110 13528 0.8187870717830771 1.0 0.9998662347735108 99.99999999999997 GOTERM_BP_FAT GO:0030308~negative regulation of cell growth 4 0.35714285714285715 0.8912692258093158 NDRG3, BCL2, GREM1, DNAJC2 751 92 13528 0.7831876338794651 1.0 0.9999336756864148 100.0 GOTERM_BP_FAT GO:0045792~negative regulation of cell size 4 0.35714285714285715 0.9177482680637086 NDRG3, BCL2, GREM1, DNAJC2 751 99 13528 0.7278107304738464 1.0 0.9999720586644221 100.0 GOTERM_BP_FAT GO:0001558~regulation of cell growth 8 0.7142857142857143 0.9183810143630279 TAOK2, NDRG3, BCL2, MAPT, GREM1, DNAJC2, IL2, MUC12 751 194 13528 0.7428171372877401 1.0 0.9999725146944484 100.0 Annotation Cluster 211 Enrichment Score: 0.1797203527131607 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030530~heterogeneous nuclear ribonucleoprotein complex 3 0.26785714285714285 0.24403666353071982 HNRNPD, HNRNPA0, HNRNPU 713 17 12782 3.1636003630063523 1.0 0.8948205485031823 98.18502226311533 GOTERM_CC_FAT GO:0005681~spliceosome 8 0.7142857142857143 0.6078831986279091 TFIP11, SF3B1, AQR, PPIL3, DHX35, DGCR14, HNRNPU, TXNL4A 713 132 12782 1.0864890135577372 1.0 0.9666223226176123 99.99985089387127 GOTERM_BP_FAT GO:0008380~RNA splicing 16 1.4285714285714286 0.6149654267952741 TFIP11, POLR2J, RP9, DGCR14, HNRNPA0, HNRNPU, PHAX, SF3B1, CIR1, AQR, PPIG, HNRNPD, PPIL3, DHX35, RBM39, TXNL4A 751 284 13528 1.0148346805198702 1.0 0.99675513830497 99.99999597360191 SP_PIR_KEYWORDS Spliceosome 7 0.625 0.622749509736666 TFIP11, SF3B1, AQR, PPIL3, DHX35, DGCR14, HNRNPU 1027 120 19235 1.092543005517689 1.0 0.9612812799123789 99.999935315528 GOTERM_BP_FAT GO:0006396~RNA processing 30 2.6785714285714284 0.6274478442658336 RNMT, POLR2J, ADAD1, RP9, DGCR14, SF3B1, SRRT, CIR1, DGCR8, HNRNPD, WDR12, PPIL3, TFB2M, DHX35, TFIP11, EXOSC9, SSB, NOP10, HNRNPA0, HNRNPU, SLBP, NOP14, PHAX, PPIG, AQR, NOP58, CPSF4, RBM39, POP7, TXNL4A 751 547 13528 0.9879332127547183 1.0 0.9971624502970801 99.9999977635184 SP_PIR_KEYWORDS mrna processing 14 1.25 0.6349072572466204 TFIP11, RNMT, DGCR14, HNRNPU, SLBP, SF3B1, CIR1, AQR, PPIL3, DHX35, RBM39, THOC5, CPSF4, TXNL4A 1027 260 19235 1.0085012358624823 1.0 0.9624498571363386 99.99995992967847 SP_PIR_KEYWORDS mrna splicing 11 0.9821428571428571 0.6828171369497674 TFIP11, SF3B1, CIR1, AQR, PPIL3, DHX35, RBM39, THOC5, DGCR14, HNRNPU, TXNL4A 1027 209 19235 0.985753087685133 1.0 0.970801777371366 99.999994874878 GOTERM_BP_FAT GO:0006397~mRNA processing 17 1.5178571428571428 0.7063186257608761 TFIP11, RNMT, POLR2J, DGCR14, HNRNPU, HNRNPA0, SLBP, PHAX, SF3B1, CIR1, AQR, HNRNPD, PPIL3, DHX35, RBM39, CPSF4, TXNL4A 751 321 13528 0.9539762144762332 1.0 0.9985271476759299 99.9999999679075 GOTERM_BP_FAT GO:0016071~mRNA metabolic process 19 1.6964285714285714 0.7508438855001592 TFIP11, CALCR, RNMT, POLR2J, SSB, DGCR14, HNRNPU, HNRNPA0, SLBP, PHAX, SF3B1, CIR1, AQR, HNRNPD, PPIL3, DHX35, CPSF4, RBM39, TXNL4A 751 370 13528 0.9250080973116925 1.0 0.999044631207764 99.99999999829207 GOTERM_BP_FAT GO:0000377~RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 7 0.625 0.8579978371617231 PHAX, SF3B1, POLR2J, HNRNPD, HNRNPA0, HNRNPU, TXNL4A 751 153 13528 0.8241386212718554 1.0 0.9998372992910203 99.99999999999993 GOTERM_BP_FAT GO:0000398~nuclear mRNA splicing, via spliceosome 7 0.625 0.8579978371617231 PHAX, SF3B1, POLR2J, HNRNPD, HNRNPA0, HNRNPU, TXNL4A 751 153 13528 0.8241386212718554 1.0 0.9998372992910203 99.99999999999993 GOTERM_BP_FAT GO:0000375~RNA splicing, via transesterification reactions 7 0.625 0.8579978371617231 PHAX, SF3B1, POLR2J, HNRNPD, HNRNPA0, HNRNPU, TXNL4A 751 153 13528 0.8241386212718554 1.0 0.9998372992910203 99.99999999999993 GOTERM_CC_FAT GO:0030529~ribonucleoprotein complex 24 2.142857142857143 0.8904199453876898 MRPL40, ACTB, TFIP11, SSB, NOP10, DGCR14, HNRNPU, HNRNPA0, SLBP, SF3B1, MRPS18C, AQR, FSIP2, CASP8, HNRNPD, PPIL3, WDR12, NOP58, DHX35, RPL19P12, POP7, SRP9, MVP, TXNL4A 713 515 12782 0.8354362123667262 1.0 0.9969849451279857 99.99999999999827 Annotation Cluster 212 Enrichment Score: 0.17474746416303374 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006820~anion transport 11 0.9821428571428571 0.2698849057599084 SLC25A12, SLC12A6, CLCN3, SLC26A5, SLC12A2, HTT, GLRA3, SLC25A1, CLIC2, SLC4A3, SLC1A1 751 143 13528 1.385639659940592 1.0 0.9837150662301384 99.63459880630342 GOTERM_BP_FAT GO:0006821~chloride transport 5 0.4464285714285714 0.4402075660676469 SLC12A6, CLCN3, SLC12A2, GLRA3, CLIC2 751 61 13528 1.4765012769858765 1.0 0.9926686151826412 99.99680434483778 GOTERM_MF_FAT GO:0008509~anion transmembrane transporter activity 9 0.8035714285714285 0.5798481384298549 SLC12A6, CLCN3, SLC12A9, SLC26A5, SLC12A2, GLRA3, CLIC2, SLC4A3, SLC1A1 725 147 12983 1.0963828289936663 1.0 0.9989895256875913 99.9998560511177 GOTERM_BP_FAT GO:0015698~inorganic anion transport 6 0.5357142857142857 0.5927118423449811 SLC12A6, CLCN3, SLC26A5, SLC12A2, GLRA3, CLIC2 751 93 13528 1.1621493922082384 1.0 0.9963031649232682 99.99998902832769 GOTERM_MF_FAT GO:0043168~anion binding 4 0.35714285714285715 0.8936206936580721 ADSS, CLCN3, GLRA3, CLIC2 725 92 12983 0.7785907046476761 1.0 0.9999724970548055 99.99999999999993 SP_PIR_KEYWORDS chloride 3 0.26785714285714285 0.914768995548352 CLCN3, GLRA3, CLIC2 1027 75 19235 0.7491723466407011 1.0 0.9970075348795447 99.99999999999997 GOTERM_MF_FAT GO:0005254~chloride channel activity 3 0.26785714285714285 0.9162322242440268 CLCN3, GLRA3, CLIC2 725 72 12983 0.7461494252873564 1.0 0.9999878148680206 100.0 GOTERM_MF_FAT GO:0031404~chloride ion binding 3 0.26785714285714285 0.9336762874173413 CLCN3, GLRA3, CLIC2 725 77 12983 0.6976981639050605 1.0 0.9999942328887367 100.0 GOTERM_MF_FAT GO:0005253~anion channel activity 3 0.26785714285714285 0.9367254230862165 CLCN3, GLRA3, CLIC2 725 78 12983 0.6887533156498674 1.0 0.9999947010274041 100.0 Annotation Cluster 213 Enrichment Score: 0.17291095815811286 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY hsa05410:Hypertrophic cardiomyopathy (HCM) 6 0.5357142857142857 0.5689597486575027 ACTB, ACTC1, DES, ITGA6, ITGAV, PRKAB2 301 85 5085 1.1924956028923197 1.0 0.9248429160058111 99.99626021767062 KEGG_PATHWAY hsa05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC) 5 0.4464285714285714 0.664490339239308 ACTB, DES, ITGA6, ITGAV, CTNNA1 301 76 5085 1.1114268228711315 1.0 0.9380516136844755 99.99982020540558 KEGG_PATHWAY hsa05414:Dilated cardiomyopathy 5 0.4464285714285714 0.801118777147156 ACTB, ACTC1, DES, ITGA6, ITGAV 301 92 5085 0.9181352015022389 1.0 0.9672504740264205 99.99999968104034 Annotation Cluster 214 Enrichment Score: 0.1712965422795162 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0050768~negative regulation of neurogenesis 4 0.35714285714285715 0.4586643581611479 DLX2, DLX1, RTN4R, MBP 751 45 13528 1.601183607042462 1.0 0.9927558920329321 99.99824293292824 GOTERM_BP_FAT GO:0010721~negative regulation of cell development 4 0.35714285714285715 0.5017500387973651 DLX2, DLX1, RTN4R, MBP 751 48 13528 1.501109631602308 1.0 0.9943294218838696 99.99959990001346 GOTERM_BP_FAT GO:0050767~regulation of neurogenesis 10 0.8928571428571428 0.5761627780498184 VEGFC, DLX2, DLX1, PLXNB2, BCL2, MAPT, RTN4R, TGIF1, TGIF2, MBP 751 166 13528 1.08513949272456 1.0 0.9958121111464205 99.99997767078295 GOTERM_BP_FAT GO:0022604~regulation of cell morphogenesis 8 0.7142857142857143 0.5946874461329368 ALDOA, SLC26A5, TAOK2, CDC42SE2, PLXNB2, MAPT, RTN4R, MBP 751 131 13528 1.1000498063650501 1.0 0.9962282216843119 99.99998994000917 GOTERM_BP_FAT GO:0050770~regulation of axonogenesis 4 0.35714285714285715 0.6192335113012027 PLXNB2, MAPT, RTN4R, MBP 751 57 13528 1.264092321349312 1.0 0.9968880761174566 99.99999669973766 GOTERM_BP_FAT GO:0031344~regulation of cell projection organization 5 0.4464285714285714 0.7344619358376354 PLXNB2, MAPT, RAC1, RTN4R, MBP 751 89 13528 1.0119840213049267 1.0 0.9987934705018321 99.99999999468054 GOTERM_BP_FAT GO:0051960~regulation of nervous system development 10 0.8928571428571428 0.7441112963967687 VEGFC, DLX2, DLX1, PLXNB2, BCL2, MAPT, RTN4R, TGIF1, TGIF2, MBP 751 192 13528 0.9381935197514425 1.0 0.9989612974472543 99.9999999972517 GOTERM_BP_FAT GO:0010720~positive regulation of cell development 4 0.35714285714285715 0.7441954661006629 VEGFC, PLXNB2, BCL2, MAPT 751 69 13528 1.0442501785059535 1.0 0.9989499576020247 99.99999999726779 GOTERM_BP_FAT GO:0010975~regulation of neuron projection development 4 0.35714285714285715 0.7529618321421623 PLXNB2, MAPT, RTN4R, MBP 751 70 13528 1.0293323188130115 1.0 0.999049299256942 99.99999999853335 GOTERM_BP_FAT GO:0045664~regulation of neuron differentiation 7 0.625 0.7534809000600312 PLXNB2, BCL2, MAPT, RTN4R, TGIF1, TGIF2, MBP 751 133 13528 0.9480692410119841 1.0 0.999047332920609 99.99999999858737 GOTERM_BP_FAT GO:0051129~negative regulation of cellular component organization 7 0.625 0.8060769933801478 MAD2L1, PSMG2, MAPT, RAC1, RTN4R, ADD1, MBP 751 142 13528 0.8879803454548865 1.0 0.9995493946928943 99.99999999998047 GOTERM_BP_FAT GO:0010769~regulation of cell morphogenesis involved in differentiation 4 0.35714285714285715 0.8077166334502016 PLXNB2, MAPT, RTN4R, MBP 751 77 13528 0.9357566534663738 1.0 0.9995612823582513 99.99999999998322 GOTERM_BP_FAT GO:0060284~regulation of cell development 10 0.8928571428571428 0.8085356050018733 VEGFC, DLX2, DLX1, PLXNB2, BCL2, MAPT, RTN4R, TGIF1, TGIF2, MBP 751 205 13528 0.8786983209379364 1.0 0.9995585463147889 99.99999999998444 Annotation Cluster 215 Enrichment Score: 0.16675906746688454 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0031091~platelet alpha granule 4 0.35714285714285715 0.6104404406092067 VEGFC, GP1BB, LEFTY2, F8 713 56 12782 1.2805049088359046 1.0 0.9657102533788374 99.99986423915172 GOTERM_CC_FAT GO:0031093~platelet alpha granule lumen 3 0.26785714285714285 0.6744159867506612 VEGFC, LEFTY2, F8 713 41 12782 1.3117367358806826 1.0 0.9736825757593293 99.9999896179164 GOTERM_CC_FAT GO:0060205~cytoplasmic membrane-bounded vesicle lumen 3 0.26785714285714285 0.7117605011427591 VEGFC, LEFTY2, F8 713 44 12782 1.2223001402524543 1.0 0.9808002469741851 99.99999818836368 GOTERM_CC_FAT GO:0031983~vesicle lumen 3 0.26785714285714285 0.7346131414275694 VEGFC, LEFTY2, F8 713 46 12782 1.1691566558936521 1.0 0.9831110151352993 99.99999944539677 Annotation Cluster 216 Enrichment Score: 0.16637853794866952 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001819~positive regulation of cytokine production 7 0.625 0.38208295144430515 TLR3, MALT1, JAK2, LBP, HSPD1, IL21, NLRP3 751 90 13528 1.4010356561621542 1.0 0.9896334840351603 99.9813794113608 GOTERM_BP_FAT GO:0051098~regulation of binding 10 0.8928571428571428 0.47670289202793314 SUMO1, AIDA, TAF6, BCL2, TLR3, MALT1, JAK2, NLRP3, ADD1, LRPAP1 751 153 13528 1.1773408875312221 1.0 0.9935168985548384 99.9990401575768 GOTERM_BP_FAT GO:0051100~negative regulation of binding 4 0.35714285714285715 0.6426366141854238 SUMO1, JAK2, NLRP3, LRPAP1 751 59 13528 1.2212417341849287 1.0 0.9975113123073691 99.99999893572515 GOTERM_BP_FAT GO:0051090~regulation of transcription factor activity 6 0.5357142857142857 0.6824266962509642 SUMO1, TAF6, TLR3, MALT1, JAK2, NLRP3 751 103 13528 1.0493193541297687 1.0 0.9982065931388044 99.99999987045582 GOTERM_BP_FAT GO:0043392~negative regulation of DNA binding 3 0.26785714285714285 0.7827760401224466 SUMO1, JAK2, NLRP3 751 51 13528 1.0596067987780997 1.0 0.9994112779525123 99.99999999985216 GOTERM_BP_FAT GO:0051101~regulation of DNA binding 6 0.5357142857142857 0.8078469270176911 SUMO1, TAF6, TLR3, MALT1, JAK2, NLRP3 751 121 13528 0.8932222601269932 1.0 0.9995569036233704 99.99999999998343 GOTERM_BP_FAT GO:0051099~positive regulation of binding 4 0.35714285714285715 0.8146398250560288 TLR3, MALT1, JAK2, ADD1 751 78 13528 0.9237597732937282 1.0 0.9995999447547695 99.99999999999127 GOTERM_BP_FAT GO:0051091~positive regulation of transcription factor activity 3 0.26785714285714285 0.8530133544484659 TLR3, MALT1, JAK2 751 60 13528 0.9006657789613849 1.0 0.999817947116123 99.99999999999986 GOTERM_BP_FAT GO:0043388~positive regulation of DNA binding 3 0.26785714285714285 0.9063129156497588 TLR3, MALT1, JAK2 751 70 13528 0.7719992391097584 1.0 0.9999566347425088 100.0 Annotation Cluster 217 Enrichment Score: 0.16291750144939326 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Peptidase M12B 3 0.26785714285714285 0.6389878564304761 ADAMTS19, ADAM29, ADAM22 1024 40 19113 1.3998779296875001 1.0 0.9999999787959648 99.9999985381916 INTERPRO IPR002870:Peptidase M12B, propeptide 3 0.26785714285714285 0.641935523061454 ADAMTS19, ADAM29, ADAM22 920 39 16659 1.3928929765886289 1.0 0.9999841656872324 99.99999489145787 INTERPRO IPR001590:Peptidase M12B, ADAM/reprolysin 3 0.26785714285714285 0.641935523061454 ADAMTS19, ADAM29, ADAM22 920 39 16659 1.3928929765886289 1.0 0.9999841656872324 99.99999489145787 UP_SEQ_FEATURE domain:Disintegrin 3 0.26785714285714285 0.6524108947709601 ADAMTS19, ADAM29, ADAM22 1024 41 19113 1.3657345655487805 1.0 0.9999999822533129 99.99999925268335 INTERPRO IPR018358:Disintegrin, conserved site 3 0.26785714285714285 0.6690149654171298 ADAMTS19, ADAM29, ADAM22 920 41 16659 1.3249469777306468 1.0 0.9999909621112919 99.99999858753948 GOTERM_MF_FAT GO:0004222~metalloendopeptidase activity 6 0.5357142857142857 0.6956250557411073 ADAMTS19, ADAM29, OSGEPL1, ADAM22, AFG3L2, PMPCB 725 104 12983 1.033129973474801 1.0 0.9994004720099908 99.99999903051147 INTERPRO IPR006025:Peptidase M, neutral zinc metallopeptidases, zinc-binding site 4 0.35714285714285715 0.9052526667955229 ADAMTS19, ADAM29, RNPEPL1, ADAM22 920 96 16659 0.7544836956521739 1.0 0.9999999949284738 100.0 Annotation Cluster 218 Enrichment Score: 0.16082297663778183 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR000047:Helix-turn-helix motif, lambda-like repressor 4 0.35714285714285715 0.2733327020727013 DLX2, DLX1, DLX6, DLX5 920 33 16659 2.194861660079052 1.0 0.9988426993585664 99.45904920621047 INTERPRO IPR017970:Homeobox, conserved site 12 1.0714285714285714 0.7395067386710548 DLX2, ADNP2, DLX1, RAX, NKX1-1, DLX6, DLX5, TGIF1, ZHX3, TGIF2, GSC2, CUX1 920 232 16659 0.9366004497751125 1.0 0.999997709877099 99.99999997184065 SP_PIR_KEYWORDS Homeobox 12 1.0714285714285714 0.7489714841064722 DLX2, ADNP2, DLX1, RAX, NKX1-1, DLX6, DLX5, TGIF1, ZHX3, TGIF2, GSC2, CUX1 1027 242 19235 0.928726049554588 1.0 0.9799196965269459 99.9999998322662 INTERPRO IPR001356:Homeobox 12 1.0714285714285714 0.7543069209356865 DLX2, ADNP2, DLX1, RAX, NKX1-1, DLX6, DLX5, TGIF1, ZHX3, TGIF2, GSC2, CUX1 920 235 16659 0.9246438482886216 1.0 0.9999982556837099 99.99999998917737 INTERPRO IPR012287:Homeodomain-related 12 1.0714285714285714 0.7685246184049752 DLX2, DLX1, RAX, NKX1-1, DMTF1, DLX6, DLX5, TGIF1, ZHX3, TGIF2, GSC2, CUX1 920 238 16659 0.9129886737303617 1.0 0.9999986698300275 99.99999999591566 SMART SM00389:HOX 12 1.0714285714285714 0.7804309590713189 DLX2, ADNP2, DLX1, RAX, NKX1-1, DLX6, DLX5, TGIF1, ZHX3, TGIF2, GSC2, CUX1 513 235 9079 0.9037202936419062 1.0 0.9992788534700392 99.99999978474057 UP_SEQ_FEATURE DNA-binding region:Homeobox 9 0.8035714285714285 0.8034350002201688 DLX2, ADNP2, DLX1, RAX, NKX1-1, DLX6, DLX5, GSC2, CUX1 1024 190 19113 0.8841334292763158 1.0 0.999999999880224 99.9999999999691 GOTERM_MF_FAT GO:0043565~sequence-specific DNA binding 27 2.410714285714286 0.9393470174805487 FEV, ATF2, NKX1-1, HAND2, HNRNPD, GATAD1, EWSR1, NFATC1, EGR1, POLL, RAX, MAFB, ZHX3, TBX1, GSC2, STAT1, DLX2, DLX1, ADNP2, DLX6, DLX5, PRDM5, TGIF1, RFX3, TGIF2, HSPD1, CUX1 725 607 12983 0.796548315628018 1.0 0.9999950209112266 100.0 Annotation Cluster 219 Enrichment Score: 0.1579773328393545 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS lipid synthesis 6 0.5357142857142857 0.6046018042942508 MOGAT3, CYP51A1, PRKAB2, LSS, SCD5, DEGS1 1027 98 19235 1.1466923673071954 1.0 0.9604472220748398 99.99987144277628 SP_PIR_KEYWORDS Fatty acid biosynthesis 3 0.26785714285714285 0.6761919472581505 PRKAB2, SCD5, DEGS1 1027 43 19235 1.3066959534430833 1.0 0.9694780466953343 99.99999306651576 GOTERM_BP_FAT GO:0006633~fatty acid biosynthetic process 4 0.35714285714285715 0.8213505799340235 PRKAB2, RNPEPL1, SCD5, DEGS1 751 79 13528 0.9120666116064657 1.0 0.9996443967750844 99.99999999999548 Annotation Cluster 220 Enrichment Score: 0.1569337015341905 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007155~cell adhesion 38 3.392857142857143 0.6451211928505501 ACHE, MAEA, EPDR1, ZAN, CLDN5, COL3A1, SPOCK1, CLDN12, MEGF10, SRC, SCARF2, CLDN15, AZGP1P1, AZGP1, CDH20, DGCR2, GP1BB, ITGAV, BCL2, RAC1, SPON2, PTPRM, TAOK2, PCDH10, F8, PTPRT, EMILIN2, CTNNA1, RAPH1, ARVCF, LAMA1, ITGA6, CDH19, RELN, SGCE, ADAM22, TRIP6, CD226, IL2 751 700 13528 0.9778657028723607 1.0 0.9974866473548805 99.99999906028562 GOTERM_BP_FAT GO:0022610~biological adhesion 38 3.392857142857143 0.6485815062012577 ACHE, MAEA, EPDR1, ZAN, CLDN5, COL3A1, SPOCK1, CLDN12, MEGF10, SRC, SCARF2, CLDN15, AZGP1P1, AZGP1, CDH20, DGCR2, GP1BB, ITGAV, BCL2, RAC1, SPON2, PTPRM, TAOK2, PCDH10, F8, PTPRT, EMILIN2, CTNNA1, RAPH1, ARVCF, LAMA1, ITGA6, CDH19, RELN, SGCE, ADAM22, TRIP6, CD226, IL2 751 701 13528 0.9764707446656954 1.0 0.9975644383487575 99.99999921100449 SP_PIR_KEYWORDS cell adhesion 20 1.7857142857142856 0.8083380555713825 PTPRM, ZAN, PCDH10, CTNNA1, EMILIN2, MEGF10, SCARF2, LAMA1, ARVCF, CDH20, DGCR2, ITGA6, GP1BB, ITGAV, CDH19, RELN, ADAM22, SPON2, TRIP6, CD226 1027 422 19235 0.8876449604747644 1.0 0.9864299411264624 99.99999999675305 Annotation Cluster 221 Enrichment Score: 0.15587160241295242 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032259~methylation 5 0.4464285714285714 0.6141047512561233 METTL5, METTL4, PRDM5, TFB2M, ETF1 751 76 13528 1.18508655126498 1.0 0.9967520518753344 99.99999580996976 GOTERM_BP_FAT GO:0008213~protein amino acid alkylation 3 0.26785714285714285 0.6447617437638916 METTL5, PRDM5, ETF1 751 39 13528 1.3856396599405922 1.0 0.9975033995637904 99.99999904315868 GOTERM_BP_FAT GO:0006479~protein amino acid methylation 3 0.26785714285714285 0.6447617437638916 METTL5, PRDM5, ETF1 751 39 13528 1.3856396599405922 1.0 0.9975033995637904 99.99999904315868 GOTERM_BP_FAT GO:0043414~biopolymer methylation 4 0.35714285714285715 0.7441954661006629 METTL5, PRDM5, TFB2M, ETF1 751 69 13528 1.0442501785059535 1.0 0.9989499576020247 99.99999999726779 GOTERM_BP_FAT GO:0006730~one-carbon metabolic process 5 0.4464285714285714 0.8748105024842399 METTL5, METTL4, PRDM5, TFB2M, ETF1 751 112 13528 0.8041658740726649 1.0 0.99989568597603 99.99999999999999 Annotation Cluster 222 Enrichment Score: 0.1541967881286713 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR018029:C2 membrane targeting protein 7 0.625 0.5339228088702797 PLCL1, DOC2A, HECW2, PLCG1, CPNE1, NEDD4L, RASA4, RBM12 920 106 16659 1.1957854799015586 1.0 0.9999406197118145 99.99961976507525 INTERPRO IPR000008:C2 calcium-dependent membrane targeting 8 0.7142857142857143 0.6365372057719841 PLCL1, DOC2A, CEP120, HECW2, PLCG1, CPNE1, NEDD4L, RASA4, RBM12 920 137 16659 1.0573786099650904 1.0 0.9999871416323942 99.99999347566741 SMART SM00239:C2 8 0.7142857142857143 0.6602715216359658 PLCL1, DOC2A, CEP120, HECW2, PLCG1, CPNE1, NEDD4L, RASA4, RBM12 513 137 9079 1.0334514306853915 1.0 0.9983112597368097 99.99993267265985 UP_SEQ_FEATURE domain:C2 4 0.35714285714285715 0.808851028485484 PLCL1, HECW2, PLCG1, NEDD4L 1024 80 19113 0.933251953125 1.0 0.9999999998961325 99.99999999998116 UP_SEQ_FEATURE domain:C2 1 3 0.26785714285714285 0.8090268735720525 DOC2A, CPNE1, RASA4, RBM12 1024 56 19113 0.9999128069196428 1.0 0.9999999998840304 99.99999999998147 UP_SEQ_FEATURE domain:C2 2 3 0.26785714285714285 0.8090268735720525 DOC2A, CPNE1, RASA4, RBM12 1024 56 19113 0.9999128069196428 1.0 0.9999999998840304 99.99999999998147 Annotation Cluster 223 Enrichment Score: 0.1539392851874893 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003899~DNA-directed RNA polymerase activity 3 0.26785714285714285 0.7003142920667182 POLR2J, POLR2J2, CTDP1, POLR2J3 725 43 12983 1.2493664795509223 1.0 0.9993621560597382 99.99999923801563 GOTERM_MF_FAT GO:0034062~RNA polymerase activity 3 0.26785714285714285 0.7003142920667182 POLR2J, POLR2J2, CTDP1, POLR2J3 725 43 12983 1.2493664795509223 1.0 0.9993621560597382 99.99999923801563 GOTERM_MF_FAT GO:0016779~nucleotidyltransferase activity 7 0.625 0.704038105032591 POLL, DNAH14, POLR2J, GMPPA, POLN, POLR2J2, CTDP1, POLR2J3 725 125 12983 1.0028248275862068 1.0 0.9993447623030854 99.99999937235903 Annotation Cluster 224 Enrichment Score: 0.15105166034257989 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003924~GTPase activity 12 1.0714285714285714 0.6349292911706619 SEPT5, GNGT1, GNAL, RAB31, GNB2, RASL10A, RAC1, TGM2, TUBB6, TUBA4A, TUBA4B, GNG11 725 211 12983 1.0184409217192352 1.0 0.9993110721429568 99.99998372539761 GOTERM_MF_FAT GO:0032561~guanyl ribonucleotide binding 21 1.875 0.6484190679445352 SEPT5, ADSS, RAB39B, GTPBP10, AK3, OLA1, DOCK8, GNAL, RAB31, RASL10A, GMPPA, PDE5A, RAC1, TGM2, TUBB6, TUBA4A, TUBA4B, RAB12, SCG5, SEPT7, PMS1 725 382 12983 0.9844484564000723 1.0 0.9993303647946535 99.99999092471764 GOTERM_MF_FAT GO:0019001~guanyl nucleotide binding 21 1.875 0.6484190679445352 SEPT5, ADSS, RAB39B, GTPBP10, AK3, OLA1, DOCK8, GNAL, RAB31, RASL10A, GMPPA, PDE5A, RAC1, TGM2, TUBB6, TUBA4A, TUBA4B, RAB12, SCG5, SEPT7, PMS1 725 382 12983 0.9844484564000723 1.0 0.9993303647946535 99.99999092471764 GOTERM_MF_FAT GO:0005525~GTP binding 20 1.7857142857142856 0.6881261069294711 SEPT5, ADSS, RAB39B, GTPBP10, AK3, OLA1, DOCK8, GNAL, RAB31, RASL10A, GMPPA, RAC1, TGM2, TUBB6, TUBA4A, TUBA4B, RAB12, SCG5, SEPT7, PMS1 725 372 12983 0.9627734519836856 1.0 0.9994055487258139 99.99999858580799 UP_SEQ_FEATURE nucleotide phosphate-binding region:GTP 14 1.25 0.8018750931056868 SEPT5, ADSS, RAB39B, GTPBP10, AK3, GNAL, RAB31, RASL10A, RAC1, TUBB6, TUBA4A, RAB12, TUBA4B, SEPT7 1024 295 19113 0.8857984639830508 1.0 0.9999999998957491 99.99999999996446 SP_PIR_KEYWORDS gtp-binding 15 1.3392857142857142 0.8423224208922095 SEPT5, ADSS, RAB39B, GTPBP10, AK3, GNAL, RAB31, RASL10A, GMPPA, RAC1, TUBB6, TUBA4A, RAB12, TUBA4B, SEPT7 1027 329 19235 0.8539198479947201 1.0 0.9910820423448577 99.9999999998128 Annotation Cluster 225 Enrichment Score: 0.1403027306841807 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0035091~phosphoinositide binding 6 0.5357142857142857 0.6621144461288296 ZCCHC2, BBS5, SNX25, ZFYVE28, SNX2, SNX24 725 100 12983 1.0744551724137932 1.0 0.9993932387634933 99.99999510010599 UP_SEQ_FEATURE domain:PX 3 0.26785714285714285 0.7247053786773182 SNX25, SNX2, SNX24 1024 47 19113 1.191385472074468 1.0 0.9999999978523672 99.99999998796876 INTERPRO IPR001683:Phox-like 3 0.26785714285714285 0.7508908929984852 SNX25, SNX2, SNX24 920 48 16659 1.1317255434782607 1.0 0.9999981930203163 99.99999998643672 SMART SM00312:PX 3 0.26785714285714285 0.7622855583099988 SNX25, SNX2, SNX24 513 48 9079 1.106115984405458 1.0 0.9992802713656065 99.99999938780692 Annotation Cluster 226 Enrichment Score: 0.1385225273445228 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE short sequence motif:DEAH box 4 0.35714285714285715 0.3919696756140031 CHD1L, HELQ, DHX35, CHD6 1024 42 19113 1.7776227678571428 1.0 0.9999973900740394 99.98507577390119 INTERPRO IPR000330:SNF2-related 3 0.26785714285714285 0.5335325746132475 CHD1L, CHD6, SMARCA2 920 32 16659 1.6975883152173912 1.0 0.9999454385097861 99.99961452703884 INTERPRO IPR002464:DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site 3 0.26785714285714285 0.641935523061454 CHD1L, DHX35, CHD6 920 39 16659 1.3928929765886289 1.0 0.9999841656872324 99.99999489145787 GOTERM_MF_FAT GO:0008026~ATP-dependent helicase activity 6 0.5357142857142857 0.6444916213958547 CHD1L, HELQ, CETN1, MOV10L1, DHX35, CHD6 725 98 12983 1.0963828289936666 1.0 0.9993571811234726 99.9999892180053 GOTERM_MF_FAT GO:0070035~purine NTP-dependent helicase activity 6 0.5357142857142857 0.6444916213958547 CHD1L, HELQ, CETN1, MOV10L1, DHX35, CHD6 725 98 12983 1.0963828289936666 1.0 0.9993571811234726 99.9999892180053 GOTERM_MF_FAT GO:0004386~helicase activity 8 0.7142857142857143 0.6704048425708072 MCM7, CHD1L, HELQ, CETN1, MOV10L1, DHX35, CHD6, SMARCA2 725 140 12983 1.0232906403940885 1.0 0.9993545798188913 99.99999666705013 UP_SEQ_FEATURE domain:Helicase C-terminal 5 0.4464285714285714 0.8199657724909739 CHD1L, HELQ, DHX35, CHD6, SMARCA2 1024 105 19113 0.8888113839285714 1.0 0.9999999999156954 99.99999999999348 GOTERM_BP_FAT GO:0006338~chromatin remodeling 3 0.26785714285714285 0.8248094987335071 CHD1L, CHD6, SMARCA2 751 56 13528 0.9649990488871979 1.0 0.999661782349352 99.99999999999682 UP_SEQ_FEATURE domain:Helicase ATP-binding 5 0.4464285714285714 0.8466740749969361 CHD1L, HELQ, DHX35, CHD6, SMARCA2 1024 110 19113 0.8484108664772727 1.0 0.9999999999792067 99.99999999999962 SP_PIR_KEYWORDS helicase 6 0.5357142857142857 0.8482911988135675 CHD1L, HELQ, MOV10L1, DHX35, CHD6, SMARCA2 1027 134 19235 0.8386257611649639 1.0 0.9913731809199615 99.99999999989352 INTERPRO IPR001650:DNA/RNA helicase, C-terminal 5 0.4464285714285714 0.8483924331803633 CHD1L, HELQ, DHX35, CHD6, SMARCA2 920 107 16659 0.8461499390491669 1.0 0.9999999248256609 99.99999999999596 INTERPRO IPR014021:Helicase, superfamily 1 and 2, ATP-binding 5 0.4464285714285714 0.8483924331803633 CHD1L, HELQ, DHX35, CHD6, SMARCA2 920 107 16659 0.8461499390491669 1.0 0.9999999248256609 99.99999999999596 SMART SM00490:HELICc 5 0.4464285714285714 0.8560540791243718 CHD1L, HELQ, DHX35, CHD6, SMARCA2 513 106 9079 0.8348045165324212 1.0 0.9998684301490863 99.99999999916976 INTERPRO IPR014001:DEAD-like helicase, N-terminal 5 0.4464285714285714 0.8583064545934198 CHD1L, HELQ, DHX35, CHD6, SMARCA2 920 109 16659 0.8306242520941364 1.0 0.9999999352687796 99.99999999999865 SMART SM00487:DEXDc 5 0.4464285714285714 0.8704379620008469 CHD1L, HELQ, DHX35, CHD6, SMARCA2 513 109 9079 0.8118282454351985 1.0 0.9998722520053976 99.99999999979234 Annotation Cluster 227 Enrichment Score: 0.1366720171926217 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Ubiquitin-like 3 0.26785714285714285 0.665432955722804 SUMO1, UHRF2, HERPUD2 1024 42 19113 1.333217075892857 1.0 0.999999988178459 99.99999961992965 INTERPRO IPR000626:Ubiquitin 3 0.26785714285714285 0.7294653246820955 SUMO1, UHRF2, HERPUD2 920 46 16659 1.180931001890359 1.0 0.9999969950146977 99.99999994774149 SMART SM00213:UBQ 3 0.26785714285714285 0.7411685603967972 SUMO1, UHRF2, HERPUD2 513 46 9079 1.1542079837274346 1.0 0.9991495916215258 99.99999812319183 INTERPRO IPR019955:Ubiquitin supergroup 3 0.26785714285714285 0.7893797559385213 SUMO1, UHRF2, HERPUD2 920 52 16659 1.0446697324414715 1.0 0.9999991756064864 99.99999999912745 Annotation Cluster 228 Enrichment Score: 0.13661724702707462 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042472~inner ear morphogenesis 4 0.35714285714285715 0.6071484092379518 MAFB, DLX6, DLX5, TBX1 751 56 13528 1.286665398516264 1.0 0.9966429453318971 99.99999423702566 GOTERM_BP_FAT GO:0043583~ear development 6 0.5357142857142857 0.6117412031669234 MAFB, DLX6, DLX5, BCL2, TBX1, CUX1 751 95 13528 1.1376830892143808 1.0 0.9967134044406558 99.99999532771722 GOTERM_BP_FAT GO:0048839~inner ear development 5 0.4464285714285714 0.6446340348839076 MAFB, DLX6, DLX5, TBX1, CUX1 751 79 13528 1.140083264508082 1.0 0.9975294874106945 99.99999903700302 GOTERM_BP_FAT GO:0042471~ear morphogenesis 4 0.35714285714285715 0.7164087619963231 MAFB, DLX6, DLX5, TBX1 751 66 13528 1.0917160957107694 1.0 0.9985594471198974 99.99999998280059 GOTERM_BP_FAT GO:0048706~embryonic skeletal system development 4 0.35714285714285715 0.8077166334502016 DLX2, DLX1, SP3, TBX1 751 77 13528 0.9357566534663738 1.0 0.9995612823582513 99.99999999998322 GOTERM_BP_FAT GO:0048562~embryonic organ morphogenesis 6 0.5357142857142857 0.8670569124312447 DLX2, MAFB, DLX6, DLX5, SP3, TBX1 751 133 13528 0.8126307780102721 1.0 0.9998697219291506 99.99999999999997 GOTERM_BP_FAT GO:0048568~embryonic organ development 7 0.625 0.9205257145849713 DLX2, PLK4, MAFB, DLX6, DLX5, SP3, TBX1 751 172 13528 0.7331000526429876 1.0 0.9999750186970603 100.0 Annotation Cluster 229 Enrichment Score: 0.13140100784538675 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004842~ubiquitin-protein ligase activity 9 0.8035714285714285 0.5798481384298549 UBE2D2, UHRF2, PPIL2, CDC23, UBR3, MALT1, NEDD4L, FBXO24, UBE2L3 725 147 12983 1.0963828289936663 1.0 0.9989895256875913 99.9998560511177 GOTERM_MF_FAT GO:0016879~ligase activity, forming carbon-nitrogen bonds 13 1.1607142857142858 0.6420744852297081 ADSS, HECW2, PPIL2, ASNSD1, CDC23, UBR3, ASNS, MALT1, UBE2L3, UBE2D2, UHRF2, FBXO24, NEDD4L 725 231 12983 1.007786236751754 1.0 0.9993649684129632 99.99998802298347 GOTERM_MF_FAT GO:0019787~small conjugating protein ligase activity 9 0.8035714285714285 0.7140857884492977 UBE2D2, UHRF2, PPIL2, CDC23, UBR3, MALT1, NEDD4L, FBXO24, UBE2L3 725 166 12983 0.9708932280847528 1.0 0.9994393849509918 99.99999963269434 UP_SEQ_FEATURE active site:Glycyl thioester intermediate 4 0.35714285714285715 0.7218066595219137 UBE2D2, HECW2, NEDD4L, UBE2L3 1024 69 19113 1.08203125 1.0 0.9999999977584217 99.99999998551691 GOTERM_BP_FAT GO:0032446~protein modification by small protein conjugation 7 0.625 0.747044005986912 SUMO1, UBE2D2, UHRF2, PPIL2, NEDD4L, FBXO24, UBE2L3 751 132 13528 0.9552515837469233 1.0 0.998994920532504 99.99999999776257 GOTERM_BP_FAT GO:0070647~protein modification by small protein conjugation or removal 8 0.7142857142857143 0.7905325034167113 SUMO1, UBE2D2, UHRF2, BRCC3, PPIL2, NEDD4L, FBXO24, UBE2L3 751 160 13528 0.9006657789613849 1.0 0.9994517248658715 99.99999999992272 GOTERM_MF_FAT GO:0016881~acid-amino acid ligase activity 10 0.8928571428571428 0.7958009437246252 UBE2D2, UHRF2, HECW2, PPIL2, CDC23, UBR3, MALT1, NEDD4L, FBXO24, UBE2L3 725 201 12983 0.8909246869102762 1.0 0.9998074360177186 99.99999999801653 GOTERM_BP_FAT GO:0016567~protein ubiquitination 6 0.5357142857142857 0.7961785169486193 UBE2D2, UHRF2, PPIL2, NEDD4L, FBXO24, UBE2L3 751 119 13528 0.9082343989526569 1.0 0.9994660172324321 99.99999999995254 KEGG_PATHWAY hsa04120:Ubiquitin mediated proteolysis 6 0.5357142857142857 0.9146167571643137 UBE2D2, BTRC, PPIL2, CDC23, NEDD4L, UBE2L3 301 137 5085 0.7398695346412202 1.0 0.9889630004631418 99.99999999998863 Annotation Cluster 230 Enrichment Score: 0.1306761905304288 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR000742:EGF-like, type 3 12 1.0714285714285714 0.5070182304306787 TMEFF2, MUC3A, CRELD2, CCBE1, ZAN, RELN, LRP2, HGFAC, MEGF10, MUC17, SCARF2, VLDLR 920 194 16659 1.120058269834155 1.0 0.999923341486821 99.99904831245557 UP_SEQ_FEATURE domain:EGF-like 3 5 0.4464285714285714 0.5751369613470116 RELN, LRP2, MEGF10, SCARF2, VLDLR 1024 75 19113 1.2443359375 1.0 0.99999994010257 99.99997386156268 UP_SEQ_FEATURE domain:EGF-like 1 7 0.625 0.6261086387179805 CRELD2, RELN, LRP2, HGFAC, MEGF10, SCARF2, VLDLR 1024 120 19113 1.0887939453125 1.0 0.9999999652970677 99.99999728068076 UP_SEQ_FEATURE domain:EGF-like 2 5 0.4464285714285714 0.6998896581201263 RELN, LRP2, HGFAC, MEGF10, SCARF2 1024 88 19113 1.060513583096591 1.0 0.999999995404755 99.99999994453248 INTERPRO IPR013091:EGF calcium-binding 4 0.35714285714285715 0.7666520564959107 CRELD2, CCBE1, LRP2, VLDLR 920 72 16659 1.005978260869565 1.0 0.9999986973816753 99.99999999534064 INTERPRO IPR001881:EGF-like calcium-binding 4 0.35714285714285715 0.9052526667955229 CRELD2, CCBE1, LRP2, VLDLR 920 96 16659 0.7544836956521739 1.0 0.9999999949284738 100.0 INTERPRO IPR018097:EGF-like calcium-binding, conserved site 4 0.35714285714285715 0.9052526667955229 CRELD2, CCBE1, LRP2, VLDLR 920 96 16659 0.7544836956521739 1.0 0.9999999949284738 100.0 INTERPRO IPR000152:EGF-type aspartate/asparagine hydroxylation conserved site 4 0.35714285714285715 0.9089404298923076 CRELD2, CCBE1, LRP2, VLDLR 920 97 16659 0.7467055132227701 1.0 0.9999999953413596 100.0 SMART SM00179:EGF_CA 4 0.35714285714285715 0.9136225433982637 CRELD2, CCBE1, LRP2, VLDLR 513 96 9079 0.7374106562703053 1.0 0.9999519046416152 99.999999999999 Annotation Cluster 231 Enrichment Score: 0.1294328013556428 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR001870:B302 (SPRY)-like 6 0.5357142857142857 0.5281313594483655 TRIM4, TRIM36, RYR3, TRIM58, RFPL1, HNRNPU 920 87 16659 1.24880059970015 1.0 0.9999424991178536 99.99953470433157 INTERPRO IPR018355:SPla/RYanodine receptor subgroup 4 0.35714285714285715 0.5912824713707743 RYR3, TRIM58, RFPL1, HNRNPU 920 55 16659 1.3169169960474307 1.0 0.9999694546822256 99.99995557081782 SMART SM00449:SPRY 4 0.35714285714285715 0.6068305178692218 RYR3, TRIM58, RFPL1, HNRNPU 513 55 9079 1.287116781853624 1.0 0.9972742781941036 99.99953935243038 UP_SEQ_FEATURE domain:B30.2/SPRY 5 0.4464285714285714 0.645831096513168 TRIM4, TRIM36, TRIM58, RFPL1, HNRNPU 1024 82 19113 1.1381121379573171 1.0 0.9999999828447012 99.99999895835917 INTERPRO IPR003879:Butyrophylin-like 4 0.35714285714285715 0.6723564849379169 TRIM4, TRIM36, TRIM58, RFPL1 920 62 16659 1.1682328190743339 1.0 0.9999910838627338 99.99999880343682 INTERPRO IPR003877:SPla/RYanodine receptor SPRY 5 0.4464285714285714 0.6879193048386589 TRIM4, RYR3, TRIM58, RFPL1, HNRNPU 920 84 16659 1.077833850931677 1.0 0.9999935094016752 99.99999945995172 INTERPRO IPR000315:Zinc finger, B-box 4 0.35714285714285715 0.7666520564959107 TRIM4, TRIM56, TRIM36, TRIM58 920 72 16659 1.005978260869565 1.0 0.9999986973816753 99.99999999534064 SMART SM00336:BBOX 4 0.35714285714285715 0.7802081272044252 TRIM4, TRIM56, TRIM36, TRIM58 513 72 9079 0.9832142083604072 1.0 0.9993631216490406 99.99999978184714 INTERPRO IPR018957:Zinc finger, C3HC4 RING-type 11 0.9821428571428571 0.8138485629059027 TRIM4, TRIM56, UHRF2, TRIM36, RNF4, RNF152, TRIM58, UBR3, RFPL1, ZSWIM2, MARCH3 920 228 16659 0.873612700228833 1.0 0.9999996990693018 99.99999999988412 INTERPRO IPR017907:Zinc finger, RING-type, conserved site 13 1.1607142857142858 0.8526070610072964 UBR3, RNF216, ZSWIM2, RNF212, TRIM4, TRIM56, TRIM36, UHRF2, RNF4, RNF152, TRIM58, ANKIB1, RFPL1 920 280 16659 0.8407104037267081 1.0 0.9999999343597453 99.99999999999744 UP_SEQ_FEATURE zinc finger region:RING-type 8 0.7142857142857143 0.9369263322400999 TRIM4, TRIM56, UHRF2, RNF4, RNF152, TRIM58, RFPL1, RNF212 1024 210 19113 0.7110491071428571 1.0 0.999999999999992 100.0 INTERPRO IPR001841:Zinc finger, RING-type 11 0.9821428571428571 0.968047437523789 TRIM4, TRIM56, UHRF2, TRIM36, RNF4, RNF152, TRIM58, ANKIB1, RFPL1, ZSWIM2, RNF212 920 296 16659 0.6729178907168039 1.0 0.9999999999930294 100.0 SMART SM00184:RING 11 0.9821428571428571 0.9745626780208432 TRIM4, TRIM56, UHRF2, TRIM36, RNF4, RNF152, TRIM58, ANKIB1, RFPL1, ZSWIM2, RNF212 513 296 9079 0.6576905853221643 1.0 0.9999992212763894 100.0 Annotation Cluster 232 Enrichment Score: 0.1293263188751619 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008015~blood circulation 10 0.8928571428571428 0.7098355037267816 SLC12A6, ACTC1, TBX20, PSEN2, PDE5A, COL1A2, BMPR2, TAC1, STAT1, EPO 751 186 13528 0.9684578268401987 1.0 0.9984921031462669 99.99999997411444 GOTERM_BP_FAT GO:0003013~circulatory system process 10 0.8928571428571428 0.7098355037267816 SLC12A6, ACTC1, TBX20, PSEN2, PDE5A, COL1A2, BMPR2, TAC1, STAT1, EPO 751 186 13528 0.9684578268401987 1.0 0.9984921031462669 99.99999997411444 GOTERM_BP_FAT GO:0008217~regulation of blood pressure 5 0.4464285714285714 0.8122797157961447 SLC12A6, ACTC1, COL1A2, BMPR2, TAC1 751 100 13528 0.9006657789613849 1.0 0.9995921156281387 99.99999999998906 Annotation Cluster 233 Enrichment Score: 0.12920049473804973 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:TPR 3 0.26785714285714285 0.08022363200256996 FIS1, P4HA2, LRP2BP 1024 9 19113 6.2216796875 1.0 0.999988497676254 77.25377247991239 UP_SEQ_FEATURE repeat:TPR 9 3 0.26785714285714285 0.48242487676486906 TTC21B, CDC23, GTF3C3 1024 30 19113 1.86650390625 1.0 0.9999994548674384 99.99913854804863 UP_SEQ_FEATURE repeat:TPR 8 3 0.26785714285714285 0.7354353074782795 TTC21B, CDC23, GTF3C3 1024 48 19113 1.16656494140625 1.0 0.9999999986878291 99.99999999404916 INTERPRO IPR011990:Tetratricopeptide-like helical 8 0.7142857142857143 0.7694968911341594 FIS1, NAPG, P4HA2, TTC21B, CDC23, LRP2BP, CLTCL1, GTF3C3 920 157 16659 0.9226806978676267 1.0 0.9999985932590261 99.99999999618726 UP_SEQ_FEATURE repeat:TPR 7 3 0.26785714285714285 0.831546229327898 TTC21B, CDC23, GTF3C3 1024 59 19113 0.949069782838983 1.0 0.9999999999559791 99.999999999998 SP_PIR_KEYWORDS tpr repeat 7 0.625 0.8611636340604685 FEM1C, FIS1, P4HA2, TTC21B, CDC23, LRP2BP, GTF3C3 1027 160 19235 0.8194072541382669 1.0 0.9929444171239844 99.99999999997087 UP_SEQ_FEATURE repeat:TPR 6 3 0.26785714285714285 0.885412199296734 TTC21B, CDC23, GTF3C3 1024 68 19113 0.8234576056985294 1.0 0.999999999998791 100.0 INTERPRO IPR019734:Tetratricopeptide repeat 5 0.4464285714285714 0.8926061919426542 P4HA2, TTC21B, CDC23, LRP2BP, GTF3C3 920 117 16659 0.7738294314381271 1.0 0.9999999900468475 99.99999999999999 SMART SM00028:TPR 5 0.4464285714285714 0.8992675127112024 P4HA2, TTC21B, CDC23, LRP2BP, GTF3C3 513 116 9079 0.7628386099347987 1.0 0.9999220438651174 99.99999999999244 INTERPRO IPR013026:Tetratricopeptide region 5 0.4464285714285714 0.9068541030668016 P4HA2, TTC21B, CDC23, LRP2BP, GTF3C3 920 121 16659 0.7482482932087675 1.0 0.9999999950295868 100.0 UP_SEQ_FEATURE repeat:TPR 5 3 0.26785714285714285 0.9194196582104286 TTC21B, CDC23, GTF3C3 1024 76 19113 0.736777857730263 1.0 0.9999999999999055 100.0 UP_SEQ_FEATURE repeat:TPR 4 3 0.26785714285714285 0.9690592734327568 TTC21B, CDC23, GTF3C3 1024 97 19113 0.57726924935567 1.0 1.0 100.0 INTERPRO IPR001440:Tetratricopeptide TPR-1 3 0.26785714285714285 0.9768087546169947 TTC21B, CDC23, GTF3C3 920 100 16659 0.5432282608695652 1.0 0.999999999999125 100.0 UP_SEQ_FEATURE repeat:TPR 1 4 0.35714285714285715 0.9889227899637135 FEM1C, TTC21B, CDC23, GTF3C3 1024 151 19113 0.4944381208609272 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:TPR 2 4 0.35714285714285715 0.9889227899637135 FEM1C, TTC21B, CDC23, GTF3C3 1024 151 19113 0.4944381208609272 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:TPR 3 3 0.26785714285714285 0.9956494980082962 TTC21B, CDC23, GTF3C3 1024 138 19113 0.40576171875 1.0 1.0 100.0 Annotation Cluster 234 Enrichment Score: 0.12779203866350514 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006493~protein amino acid O-linked glycosylation 3 0.26785714285714285 0.4072309444222758 GALNT3, TRAK2, GALNT7 751 25 13528 2.161597869507324 1.0 0.990948730362974 99.99112722561188 GOTERM_BP_FAT GO:0009100~glycoprotein metabolic process 10 0.8928571428571428 0.7948554906180316 GALNT3, GAL3ST4, ACHE, TRAK2, GALNT7, HPSE, PSEN2, RPN2, LRP2, ALG12 751 202 13528 0.8917482960013711 1.0 0.9994564498957661 99.99999999994674 GOTERM_BP_FAT GO:0070085~glycosylation 6 0.5357142857142857 0.8445440730514119 GALNT3, TRAK2, GALNT7, RPN2, LRP2, ALG12 751 128 13528 0.8443741677762983 1.0 0.9997783363558931 99.99999999999962 GOTERM_BP_FAT GO:0043413~biopolymer glycosylation 6 0.5357142857142857 0.8445440730514119 GALNT3, TRAK2, GALNT7, RPN2, LRP2, ALG12 751 128 13528 0.8443741677762983 1.0 0.9997783363558931 99.99999999999962 GOTERM_BP_FAT GO:0006486~protein amino acid glycosylation 6 0.5357142857142857 0.8445440730514119 GALNT3, TRAK2, GALNT7, RPN2, LRP2, ALG12 751 128 13528 0.8443741677762983 1.0 0.9997783363558931 99.99999999999962 GOTERM_BP_FAT GO:0009101~glycoprotein biosynthetic process 7 0.625 0.8775095723922338 GALNT3, GAL3ST4, TRAK2, GALNT7, RPN2, LRP2, ALG12 751 158 13528 0.7980582851556575 1.0 0.9999024130053857 100.0 Annotation Cluster 235 Enrichment Score: 0.12652466607544624 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0034703~cation channel complex 9 0.8035714285714285 0.4554189259789585 SCN1A, SCN3A, SCN2A, SCN9A, KCTD18, SCN7A, KCTD13, KCNV2, KCNG2 713 132 12782 1.2223001402524543 1.0 0.9559637091013419 99.98349254081535 INTERPRO IPR003131:Potassium channel, voltage dependent, Kv, tetramerisation 4 0.35714285714285715 0.5528082189302764 KCTD18, KCTD13, KCNV2, KCNG2 920 52 16659 1.3928929765886289 1.0 0.999953146784515 99.99980663337638 GOTERM_MF_FAT GO:0022843~voltage-gated cation channel activity 9 0.8035714285714285 0.5798481384298549 SCN1A, SCN3A, SCN2A, SCN9A, KCTD18, SCN7A, KCTD13, KCNV2, KCNG2 725 147 12983 1.0963828289936663 1.0 0.9989895256875913 99.9998560511177 GOTERM_MF_FAT GO:0022832~voltage-gated channel activity 11 0.9821428571428571 0.6532458489860529 CLCN3, SCN1A, SCN3A, SCN2A, SCN9A, KCTD18, CLIC2, SCN7A, KCTD13, KCNV2, KCNG2 725 195 12983 1.0101715296198055 1.0 0.9993549545823529 99.99999267630083 GOTERM_MF_FAT GO:0005244~voltage-gated ion channel activity 11 0.9821428571428571 0.6532458489860529 CLCN3, SCN1A, SCN3A, SCN2A, SCN9A, KCTD18, CLIC2, SCN7A, KCTD13, KCNV2, KCNG2 725 195 12983 1.0101715296198055 1.0 0.9993549545823529 99.99999267630083 INTERPRO IPR011333:BTB/POZ fold 9 0.8035714285714285 0.7875286552065397 KBTBD2, LZTR1, KLHL22, KCTD18, KLHL23, KCTD13, KCNV2, KLHL3, KCNG2 920 181 16659 0.9003783329329811 1.0 0.9999991898063452 99.99999999899326 GOTERM_CC_FAT GO:0008076~voltage-gated potassium channel complex 4 0.35714285714285715 0.8649554315989544 KCTD18, KCTD13, KCNV2, KCNG2 713 86 12782 0.8338171499396588 1.0 0.9953571967984912 99.99999999996537 GOTERM_CC_FAT GO:0034705~potassium channel complex 4 0.35714285714285715 0.8649554315989544 KCTD18, KCTD13, KCNV2, KCNG2 713 86 12782 0.8338171499396588 1.0 0.9953571967984912 99.99999999996537 INTERPRO IPR000210:BTB/POZ-like 8 0.7142857142857143 0.870314804757414 KBTBD2, LZTR1, KLHL22, KCTD18, KLHL23, KCTD13, KLHL3, KCNG2 920 179 16659 0.8092786009230022 1.0 0.999999965841861 99.99999999999969 GOTERM_BP_FAT GO:0006813~potassium ion transport 7 0.625 0.8846595740479968 SLC12A6, SLC12A2, VPS4B, KCTD18, KCTD13, KCNV2, KCNG2 751 160 13528 0.7880825565912117 1.0 0.9999204533481897 100.0 SMART SM00225:BTB 8 0.7142857142857143 0.8852332213995022 KBTBD2, LZTR1, KLHL22, KCTD18, KLHL23, KCTD13, KLHL3, KCNG2 513 179 9079 0.7909656201335119 1.0 0.9999127443182856 99.99999999995791 GOTERM_MF_FAT GO:0005249~voltage-gated potassium channel activity 4 0.35714285714285715 0.9229266429811469 KCTD18, KCTD13, KCNV2, KCNG2 725 100 12983 0.716303448275862 1.0 0.999991141477494 100.0 GOTERM_MF_FAT GO:0005267~potassium channel activity 4 0.35714285714285715 0.9812844667421511 KCTD18, KCTD13, KCNV2, KCNG2 725 133 12983 0.5385740212600466 1.0 0.9999998839055037 100.0 Annotation Cluster 236 Enrichment Score: 0.11939735676583495 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:SET 3 0.26785714285714285 0.7458066798713152 PRDM6, PRDM5, SMYD3 1024 49 19113 1.142757493622449 1.0 0.9999999991964835 99.99999999706883 INTERPRO IPR001214:SET 3 0.26785714285714285 0.7610453279586451 PRDM6, PRDM5, SMYD3 920 49 16659 1.1086291038154392 1.0 0.9999985226351665 99.99999999313097 SMART SM00317:SET 3 0.26785714285714285 0.7722735072845309 PRDM6, PRDM5, SMYD3 513 49 9079 1.0835421888053467 1.0 0.9993360766283821 99.9999996520637 Annotation Cluster 237 Enrichment Score: 0.11821893752324322 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048610~reproductive cellular process 9 0.8035714285714285 0.6819791249655572 NME5, TRIM36, BCL2, ADAD1, LEFTY2, ZAN, ARSA, MOV10L1, HSD17B4 751 162 13528 1.0007397544015386 1.0 0.9982153013702054 99.9999998671596 GOTERM_BP_FAT GO:0003006~reproductive developmental process 13 1.1607142857142858 0.7918528523050282 ERMP1, HMGB2, DMRT3, ADAD1, DMRT1, DMRT2, MOV10L1, INHA, VGF, NME5, BCL2, LEFTY2, HSD17B4 751 262 13528 0.8937904676716031 1.0 0.9994469028490892 99.99999999993096 GOTERM_BP_FAT GO:0007281~germ cell development 5 0.4464285714285714 0.8183283945472001 NME5, BCL2, ADAD1, LEFTY2, MOV10L1 751 101 13528 0.8917482960013711 1.0 0.9996208181297417 99.9999999999939 Annotation Cluster 238 Enrichment Score: 0.11621907058912505 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR015609:Molecular chaperone, heat shock protein, Hsp40, DnaJ 3 0.26785714285714285 0.6690149654171298 DNAJC18, DNAJB2, DNAJC2 920 41 16659 1.3249469777306468 1.0 0.9999909621112919 99.99999858753948 UP_SEQ_FEATURE domain:J 3 0.26785714285714285 0.7458066798713152 DNAJC18, DNAJB2, DNAJC2 1024 49 19113 1.142757493622449 1.0 0.9999999991964835 99.99999999706883 INTERPRO IPR001623:Heat shock protein DnaJ, N-terminal 3 0.26785714285714285 0.7508908929984852 DNAJC18, DNAJB2, DNAJC2 920 48 16659 1.1317255434782607 1.0 0.9999981930203163 99.99999998643672 INTERPRO IPR018253:Heat shock protein DnaJ, conserved site 3 0.26785714285714285 0.7610453279586451 DNAJC18, DNAJB2, DNAJC2 920 49 16659 1.1086291038154392 1.0 0.9999985226351665 99.99999999313097 SMART SM00271:DnaJ 3 0.26785714285714285 0.7622855583099988 DNAJC18, DNAJB2, DNAJC2 513 48 9079 1.106115984405458 1.0 0.9992802713656065 99.99999938780692 GOTERM_MF_FAT GO:0031072~heat shock protein binding 3 0.26785714285714285 0.9236733672125954 DNAJC18, DNAJB2, DNAJC2 725 74 12983 0.7259832246039143 1.0 0.9999909929146089 100.0 Annotation Cluster 239 Enrichment Score: 0.1155753421869528 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:LRR 8 9 0.8035714285714285 0.547837241545254 PHLPP1, LRRTM2, LRRC30, FSIP2, RTN4R, TLR3, FBXL13, TLR5, LRCH4 1024 149 19113 1.127418466862416 1.0 0.9999999147278071 99.99992126109919 UP_SEQ_FEATURE repeat:LRR 6 12 1.0714285714285714 0.573207774959153 PHLPP1, STK11IP, LRRTM2, LRRC30, FSIP2, RTN4R, TLR3, FBXL13, LRRC17, TLR5, LRCH4, NLRP3 1024 210 19113 1.0665736607142857 1.0 0.9999999491899202 99.99997167827792 UP_SEQ_FEATURE repeat:LRR 9 8 0.7142857142857143 0.5888325842190412 PHLPP1, LRRTM2, LRRC30, FSIP2, RTN4R, TLR3, TLR5, LRCH4 1024 135 19113 1.106076388888889 1.0 0.9999999407566205 99.99998536813692 UP_SEQ_FEATURE repeat:LRR 7 10 0.8928571428571428 0.6108068058470405 PHLPP1, LRRTM2, LRRC30, FSIP2, RTN4R, TLR3, FBXL13, TLR5, LRCH4, NLRP3 1024 177 19113 1.0545219809322035 1.0 0.9999999557673594 99.99999446753671 UP_SEQ_FEATURE repeat:LRR 5 12 1.0714285714285714 0.6975588559744044 PHLPP1, STK11IP, LRRTM2, LRRC30, FSIP2, RTN4R, TLR3, FBXL13, LRRC17, TLR5, LRCH4, NLRP3 1024 231 19113 0.9696124188311688 1.0 0.9999999953820706 99.99999993638875 INTERPRO IPR000483:Cysteine-rich flanking region, C-terminal 5 0.4464285714285714 0.7224936350281017 GP1BB, RTN4R, TLR3, LRRC17, TLR5 920 88 16659 1.0288414031620552 1.0 0.9999971009687884 99.9999999207865 SMART SM00082:LRRCT 5 0.4464285714285714 0.7391408082820946 GP1BB, RTN4R, TLR3, LRRC17, TLR5 513 88 9079 1.0055599858231437 1.0 0.9992282094865439 99.9999979201523 SP_PIR_KEYWORDS leucine-rich repeat 16 1.4285714285714286 0.7418208797775069 PHLPP1, STK11IP, LRRC30, RTN4R, TLR3, LRRC17, TLR5, NLRP3, BPI, GP1BB, LRRTM2, FSIP2, FBXL13, LRCH4, LRWD1, FBXL18 1027 322 19235 0.9306488778145356 1.0 0.9790971528058 99.99999974710363 INTERPRO IPR001611:Leucine-rich repeat 11 0.9821428571428571 0.7439930646192996 PHLPP1, STK11IP, LRRTM2, LRRC30, RTN4R, TLR3, LRRC17, TLR5, LRCH4, LRWD1, NLRP3 920 213 16659 0.9351347213717085 1.0 0.9999978683340783 99.99999997880256 UP_SEQ_FEATURE repeat:LRR 15 3 0.26785714285714285 0.7655043731675185 PHLPP1, TLR3, TLR5 1024 51 19113 1.0979434742647058 1.0 0.9999999995572699 99.9999999992973 UP_SEQ_FEATURE repeat:LRR 13 4 0.35714285714285715 0.780250058336429 PHLPP1, FSIP2, TLR3, TLR5 1024 76 19113 0.9823704769736841 1.0 0.9999999997201817 99.99999999977751 UP_SEQ_FEATURE repeat:LRR 4 12 1.0714285714285714 0.7969082128504161 PHLPP1, STK11IP, LRRTM2, LRRC30, FSIP2, RTN4R, TLR3, FBXL13, LRRC17, TLR5, LRCH4, NLRP3 1024 252 19113 0.8888113839285714 1.0 0.999999999884777 99.9999999999449 UP_SEQ_FEATURE repeat:LRR 1 15 1.3392857142857142 0.8099027148361433 PHLPP1, STK11IP, LRRC30, RTN4R, TLR3, LRRC17, TLR5, NLRP3, BPI, LRRTM2, FSIP2, FBXL13, LRCH4, LRWD1, FBXL18 1024 318 19113 0.8804263708726415 1.0 0.9999999998770428 99.99999999998292 UP_SEQ_FEATURE repeat:LRR 2 15 1.3392857142857142 0.8133966502712944 PHLPP1, STK11IP, LRRC30, RTN4R, TLR3, LRRC17, TLR5, NLRP3, BPI, LRRTM2, FSIP2, FBXL13, LRCH4, LRWD1, FBXL18 1024 319 19113 0.8776664135971786 1.0 0.9999999998923432 99.9999999999877 UP_SEQ_FEATURE repeat:LRR 3 14 1.25 0.8164388178433926 PHLPP1, STK11IP, LRRC30, RTN4R, TLR3, LRRC17, TLR5, NLRP3, LRRTM2, FSIP2, FBXL13, LRCH4, LRWD1, FBXL18 1024 299 19113 0.8739483173076922 1.0 0.9999999999028553 99.9999999999908 UP_SEQ_FEATURE repeat:LRR 14 3 0.26785714285714285 0.8385031650730861 PHLPP1, TLR3, TLR5 1024 60 19113 0.933251953125 1.0 0.9999999999678517 99.99999999999905 INTERPRO IPR003591:Leucine-rich repeat, typical subtype 6 0.5357142857142857 0.8552185526107225 LRRTM2, RTN4R, TLR3, TLR5, LRCH4, LRWD1 920 131 16659 0.829356123464985 1.0 0.9999999372677937 99.9999999999981 SMART SM00369:LRR_TYP 6 0.5357142857142857 0.868833059615556 LRRTM2, RTN4R, TLR3, TLR5, LRCH4, LRWD1 513 131 9079 0.8105888129994197 1.0 0.9998834896557806 99.9999999997558 UP_SEQ_FEATURE repeat:LRR 12 4 0.35714285714285715 0.871715836116277 PHLPP1, FSIP2, TLR3, TLR5 1024 91 19113 0.8204412774725275 1.0 0.9999999999969967 99.99999999999999 UP_SEQ_FEATURE repeat:LRR 10 5 0.4464285714285714 0.8783834389497766 PHLPP1, LRRTM2, FSIP2, TLR3, TLR5 1024 117 19113 0.7976512419871794 1.0 0.9999999999980269 99.99999999999999 UP_SEQ_FEATURE repeat:LRR 11 4 0.35714285714285715 0.9155628403269213 PHLPP1, FSIP2, TLR3, TLR5 1024 102 19113 0.7319623161764706 1.0 0.9999999999998745 100.0 INTERPRO IPR000372:Leucine-rich repeat, cysteine-rich flanking region, N-terminal 4 0.35714285714285715 0.915927982009345 GP1BB, LRRTM2, RTN4R, TLR3 920 99 16659 0.7316205533596838 1.0 0.9999999964899471 100.0 SMART SM00013:LRRNT 4 0.35714285714285715 0.9236818607579671 GP1BB, LRRTM2, RTN4R, TLR3 513 99 9079 0.7150648788075689 1.0 0.9999660756846104 99.9999999999998 Annotation Cluster 240 Enrichment Score: 0.10513381576007874 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE region of interest:Linker 2 3 0.26785714285714285 0.13246406285625856 DES, LMNB1, NEFH 1024 12 19113 4.666259765625 1.0 0.9999795897633352 91.923268800267 UP_SEQ_FEATURE region of interest:Linker 1 3 0.26785714285714285 0.8949858327440996 DES, LMNB1, NEFH 1024 70 19113 0.7999302455357143 1.0 0.9999999999993945 100.0 UP_SEQ_FEATURE region of interest:Coil 1A 3 0.26785714285714285 0.8949858327440996 DES, LMNB1, NEFH 1024 70 19113 0.7999302455357143 1.0 0.9999999999993945 100.0 UP_SEQ_FEATURE region of interest:Coil 1B 3 0.26785714285714285 0.8949858327440996 DES, LMNB1, NEFH 1024 70 19113 0.7999302455357143 1.0 0.9999999999993945 100.0 UP_SEQ_FEATURE region of interest:Rod 3 0.26785714285714285 0.8994885933040953 DES, LMNB1, NEFH 1024 71 19113 0.788663622359155 1.0 0.9999999999995978 100.0 UP_SEQ_FEATURE region of interest:Head 3 0.26785714285714285 0.9079588561241481 DES, LMNB1, NEFH 1024 73 19113 0.767056399828767 1.0 0.9999999999997643 100.0 INTERPRO IPR018039:Intermediate filament protein, conserved site 3 0.26785714285714285 0.9129790142805019 DES, LMNB1, NEFH 920 72 16659 0.7544836956521739 1.0 0.9999999963526484 100.0 INTERPRO IPR016044:Filament 3 0.26785714285714285 0.9129790142805019 DES, LMNB1, NEFH 920 72 16659 0.7544836956521739 1.0 0.9999999963526484 100.0 UP_SEQ_FEATURE region of interest:Tail 3 0.26785714285714285 0.9157573003221581 DES, LMNB1, NEFH 1024 75 19113 0.7466015625 1.0 0.99999999999986 100.0 SP_PIR_KEYWORDS Intermediate filament 3 0.26785714285714285 0.9253925034906906 DES, LMNB1, NEFH 1027 78 19235 0.7203580256160587 1.0 0.9976396847201324 100.0 GOTERM_CC_FAT GO:0005882~intermediate filament 3 0.26785714285714285 0.9996917652813364 DES, LMNB1, NEFH 713 183 12782 0.29388637251971583 1.0 0.9999999955745283 100.0 GOTERM_CC_FAT GO:0045111~intermediate filament cytoskeleton 3 0.26785714285714285 0.999750792450516 DES, LMNB1, NEFH 713 187 12782 0.2876000330005775 1.0 0.999999997060126 100.0 Annotation Cluster 241 Enrichment Score: 0.10197093614611313 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032504~multicellular organism reproduction 26 2.3214285714285716 0.68546638635606 ERMP1, HMGB2, ADAD1, TAC1, MOV10L1, COMT, VGF, NDRG3, BCL2, LEFTY2, SPATA4, IHH, SPATA24, ADAM29, HTT, MSTN, INHA, CDO1, HERPUD2, BOLL, NME5, TXNDC2, SBF1, SPAG4, SP3, TSSK2 751 487 13528 0.961696519630226 1.0 0.99823340995715 99.99999989088171 GOTERM_BP_FAT GO:0048609~reproductive process in a multicellular organism 26 2.3214285714285716 0.68546638635606 ERMP1, HMGB2, ADAD1, TAC1, MOV10L1, COMT, VGF, NDRG3, BCL2, LEFTY2, SPATA4, IHH, SPATA24, ADAM29, HTT, MSTN, INHA, CDO1, HERPUD2, BOLL, NME5, TXNDC2, SBF1, SPAG4, SP3, TSSK2 751 487 13528 0.961696519630226 1.0 0.99823340995715 99.99999989088171 SP_PIR_KEYWORDS spermatogenesis 6 0.5357142857142857 0.7475908555145013 NME5, TXNDC2, ADAD1, TSSK2, BOLL, SPATA24 1027 116 19235 0.96875734479401 1.0 0.9800068940900061 99.99999981826309 GOTERM_BP_FAT GO:0048232~male gamete generation 15 1.3392857142857142 0.8145760364360932 HMGB2, ADAM29, HTT, ADAD1, MOV10L1, HERPUD2, BOLL, NME5, TXNDC2, SBF1, NDRG3, SPAG4, TSSK2, SPATA4, SPATA24 751 308 13528 0.8772718626247255 1.0 0.9996045473827178 99.99999999999122 GOTERM_BP_FAT GO:0007283~spermatogenesis 15 1.3392857142857142 0.8145760364360932 HMGB2, ADAM29, HTT, ADAD1, MOV10L1, HERPUD2, BOLL, NME5, TXNDC2, SBF1, NDRG3, SPAG4, TSSK2, SPATA4, SPATA24 751 308 13528 0.8772718626247255 1.0 0.9996045473827178 99.99999999999122 GOTERM_BP_FAT GO:0019953~sexual reproduction 21 1.875 0.8927831015772583 HMGB2, ADAM29, HTT, ZAN, ADAD1, MOV10L1, VGF, HERPUD2, BOLL, NME5, TXNDC2, TRIM36, SBF1, NDRG3, SPAG4, BCL2, LEFTY2, ARSA, TSSK2, SPATA4, SPATA24 751 458 13528 0.8259380505759425 1.0 0.9999346899834004 100.0 GOTERM_BP_FAT GO:0007276~gamete generation 17 1.5178571428571428 0.9288763809615757 HMGB2, ADAM29, HTT, ADAD1, MOV10L1, HERPUD2, BOLL, NME5, TXNDC2, SBF1, NDRG3, SPAG4, BCL2, LEFTY2, TSSK2, SPATA4, SPATA24 751 395 13528 0.7752566198654958 1.0 0.9999829402248953 100.0 Annotation Cluster 242 Enrichment Score: 0.09646834348632641 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044459~plasma membrane part 122 10.892857142857142 0.5857628679054712 ENAH, MAEA, SEC31A, SCN3A, VAPA, TLR3, AZGP1, CHRNA7, CHRNA1, SLC4A3, MUC12, GJD2, SLC12A6, PTPRM, GNB1L, ABCB11, SCN2A, PTPRN, CTNNA1, DOC2A, MC2R, SLC40A1, CD226, ADD1, CLCN3, SCN1A, ACHE, BBS5, FGFR3, BBS7, PANX2, BBS9, BMPR2, NOSTRIN, NPY6R, EPHB4, SRC, AZGP1P1, ITGAV, RAC1, SCN9A, OBSL1, GRID2IP, ADAM29, TRPC3, ABCB1, SHANK3, ABCB4, GNGT1, EPHA4, GPR35, P2RX6, ITGA6, CD274, KCTD18, HSPD1, KCTD13, TRIP6, CLTCL1, GJA8, AP1B1, GLRA3, CLDN5, AP3S1, GJA5, MBP, SLC23A1, GPC2, AP1S1, SDPR, MAPT, RASL10A, CASP8, ATP8B1, MC5R, CALCRL, SCN7A, GPC1, SLC1A1, MLANA, PILRB, KCNG2, IHH, RAB39B, CYB5A, INHA, FMN1, EPB41L3, BPI, CHRM5, MUC3A, XIRP2, PSEN2, DOK7, CYBRD1, SGCE, STEAP1, DEGS1, CPLX4, SNAP29, CALCR, TFR2, ABI2, GNG11, COMT, CLDN12, GJC3, CLDN15, GP1BB, DLGAP1, PTPRD, SLC12A2, NF2, RAPH1, KCNV2, RAB31, PPP1R9A, ARSA, JAK2, ABCC1, LRP2, ABCC6, GFRA3 713 2203 12782 0.9927836515168974 1.0 0.9621615863236906 99.9996726296852 GOTERM_CC_FAT GO:0005887~integral to plasma membrane 57 5.089285714285714 0.9244983057442793 GJA8, MAEA, SCN3A, GLRA3, TLR3, SLC23A1, ATP8B1, MC5R, CHRNA7, CALCRL, SCN7A, CHRNA1, SLC4A3, SLC1A1, GPC1, PILRB, MLANA, MUC12, KCNG2, SLC12A6, PTPRM, ABCB11, SCN2A, PTPRN, BPI, CHRM5, MC2R, PSEN2, SGCE, STEAP1, SLC40A1, CD226, DEGS1, CALCR, SCN1A, FGFR3, TFR2, BMPR2, NPY6R, EPHB4, GP1BB, ITGAV, SCN9A, PTPRD, TRPC3, ADAM29, SLC12A2, KCNV2, ABCB4, EPHA4, GPR35, P2RX6, ITGA6, KCTD18, ABCC1, TRIP6, KCTD13 713 1188 12782 0.8601371357332086 1.0 0.9985459424499596 99.99999999999999 GOTERM_CC_FAT GO:0031226~intrinsic to plasma membrane 57 5.089285714285714 0.9483464265621676 GJA8, MAEA, SCN3A, GLRA3, TLR3, SLC23A1, ATP8B1, MC5R, CHRNA7, CALCRL, SCN7A, CHRNA1, SLC4A3, SLC1A1, GPC1, PILRB, MLANA, MUC12, KCNG2, SLC12A6, PTPRM, ABCB11, SCN2A, PTPRN, BPI, CHRM5, MC2R, PSEN2, SGCE, STEAP1, SLC40A1, CD226, DEGS1, CALCR, SCN1A, FGFR3, TFR2, BMPR2, NPY6R, EPHB4, GP1BB, ITGAV, SCN9A, PTPRD, TRPC3, ADAM29, SLC12A2, KCNV2, ABCB4, EPHA4, GPR35, P2RX6, ITGA6, KCTD18, ABCC1, TRIP6, KCTD13 713 1215 12782 0.8410229771613597 1.0 0.9993982487618756 100.0 Annotation Cluster 243 Enrichment Score: 0.09626343006026435 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Lectin 8 0.7142857142857143 0.7501845778860422 GALNT3, DGCR2, GALNT7, NPTX2, ZG16, GALNTL6, COLEC12, LMAN1 1027 159 19235 0.9423551530071713 1.0 0.9797966290727236 99.99999984373375 GOTERM_MF_FAT GO:0005529~sugar binding 10 0.8928571428571428 0.7662116262469362 GALNT3, ALDOA, DGCR2, CDIPT, GALNT7, NPTX2, ZG16, GALNTL6, COLEC12, LMAN1 725 195 12983 0.9183377541998232 1.0 0.9997203885483066 99.99999998381683 GOTERM_MF_FAT GO:0030246~carbohydrate binding 16 1.4285714285714286 0.8947317329446086 GALNT3, ALDOA, F11, CDIPT, NOMO3, GALNT7, COLEC12, NLRP3, LMAN1, LRPAP1, DGCR2, NPTX2, ZG16, GALNTL6, SERPIND1, IL2 725 354 12983 0.8093824274303526 1.0 0.9999706900174927 99.99999999999993 Annotation Cluster 244 Enrichment Score: 0.09437947432791446 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0022900~electron transport chain 8 0.7142857142857143 0.44660782062010324 SLC25A12, NDUFB3, AIFM3, NDUFV2, CYBRD1, CYB5A, STEAP2, STEAP1 751 114 13528 1.264092321349312 1.0 0.9927185065449012 99.99739707278457 GOTERM_BP_FAT GO:0022904~respiratory electron transport chain 3 0.26785714285714285 0.8770175550634116 SLC25A12, NDUFB3, NDUFV2 751 64 13528 0.8443741677762983 1.0 0.999902126616719 99.99999999999999 SP_PIR_KEYWORDS mitochondrion inner membrane 8 0.7142857142857143 0.8950372614519206 SLC25A12, NDUFB3, ATP5J2, SLC25A31, NDUFV2, COQ10B, SLC25A1, SLC25A40 1027 193 19235 0.776344400663939 1.0 0.995742030725788 99.99999999999952 GOTERM_BP_FAT GO:0045333~cellular respiration 3 0.26785714285714285 0.973886961336798 SLC25A12, NDUFB3, NDUFV2 751 97 13528 0.557112852965805 1.0 0.999999359588435 100.0 GOTERM_BP_FAT GO:0015980~energy derivation by oxidation of organic compounds 4 0.35714285714285715 0.9881397058014857 SLC25A12, NDUFB3, NDUFV2, MC4R 751 144 13528 0.5003698772007693 1.0 0.9999999580952688 100.0 Annotation Cluster 245 Enrichment Score: 0.09229033644456236 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016573~histone acetylation 3 0.26785714285714285 0.7534993514521742 BRD1, HAT1, BRD8 751 48 13528 1.125832223701731 1.0 0.9990357186474436 99.99999999858925 GOTERM_BP_FAT GO:0006473~protein amino acid acetylation 3 0.26785714285714285 0.791834303879789 BRD1, HAT1, BRD8 751 52 13528 1.039229744955444 1.0 0.9994538126852377 99.99999999993085 GOTERM_BP_FAT GO:0016570~histone modification 6 0.5357142857142857 0.8134790281376383 BRD1, BRCC3, PRDM5, HDAC10, HAT1, BRD8 751 122 13528 0.885900766191526 1.0 0.9995988672999341 99.99999999999025 GOTERM_BP_FAT GO:0016569~covalent chromatin modification 6 0.5357142857142857 0.8346971508924423 BRD1, BRCC3, PRDM5, HDAC10, HAT1, BRD8 751 126 13528 0.8577769323441761 1.0 0.999722679249877 99.99999999999886 GOTERM_BP_FAT GO:0043543~protein amino acid acylation 3 0.26785714285714285 0.8530133544484659 BRD1, HAT1, BRD8 751 60 13528 0.9006657789613849 1.0 0.999817947116123 99.99999999999986 Annotation Cluster 246 Enrichment Score: 0.0919691021226715 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009611~response to wounding 30 2.6785714285714284 0.5577009480867984 ACHE, COL3A1, TLR3, TAC1, TLR5, LMAN1, TMED7, MIA3, GP1BB, AOAH, BCL2, KLKB1, RAC1, SERPINE1, SCN9A, TICAM2, LOX, LBP, TFPI2, EPO, F11, F8, MSTN, ANXA5, CDO1, NLRP3, AOX1, SERPINB2, TFPI, JAK2, SERPIND1 751 530 13528 1.0196216365600583 1.0 0.9954394897751295 99.99995222144165 GOTERM_BP_FAT GO:0006954~inflammatory response 13 1.1607142857142858 0.9522528164830945 F8, TAC1, TLR3, TLR5, NLRP3, CDO1, TMED7, AOAH, KLKB1, AOX1, RAC1, SCN9A, TICAM2, LBP 751 325 13528 0.7205326231691077 1.0 0.999994938410137 100.0 GOTERM_BP_FAT GO:0006952~defense response 21 1.875 0.9975600423640659 ALS2, F8, SOCS6, TLR3, SAMHD1, TAC1, MALT1, COLEC12, TLR5, CDO1, NLRP3, TMED7, BPI, TMEM173, AOAH, KLKB1, BCL2, RAC1, AOX1, TICAM2, SCN9A, LBP 751 615 13528 0.6150888246565555 1.0 0.9999999998655619 100.0 Annotation Cluster 247 Enrichment Score: 0.09119700858631054 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS prenylation 10 0.8928571428571428 0.4535360435399177 CPLX4, GNGT1, RAB31, PPP1R16B, LMNB1, RAB39B, RASL10A, RAC1, GNG11, RAB12 1027 156 19235 1.2005967093600978 1.0 0.9158294708225783 99.9854305839827 UP_SEQ_FEATURE short sequence motif:Effector region 5 0.4464285714285714 0.7551248826284849 RAB31, RAB39B, RASL10A, RAC1, RAB12 1024 95 19113 0.9823704769736842 1.0 0.9999999994848202 99.999999998487 UP_SEQ_FEATURE lipid moiety-binding region:S-geranylgeranyl cysteine 5 0.4464285714285714 0.8021724814409894 RAB31, RAB39B, RASL10A, RAC1, RAB12 1024 102 19113 0.9149528952205882 1.0 0.9999999998842783 99.9999999999654 INTERPRO IPR003579:Ras small GTPase, Rab type 3 0.26785714285714285 0.8573339531571338 RAB31, RAB39B, RAB12 920 61 16659 0.8905381325730577 1.0 0.9999999383746164 99.99999999999851 SMART SM00175:RAB 3 0.26785714285714285 0.8662109432973707 RAB31, RAB39B, RAB12 513 61 9079 0.8703863483846227 1.0 0.9998904093888054 99.99999999968313 INTERPRO IPR001806:Ras GTPase 5 0.4464285714285714 0.944392745940213 RAB31, RAB39B, RASL10A, RAC1, RAB12 920 135 16659 0.6706521739130434 1.0 0.9999999997365588 100.0 INTERPRO IPR013753:Ras 4 0.35714285714285715 0.9715723877327436 RAB31, RAB39B, RAC1, RAB12 920 125 16659 0.5794434782608696 1.0 0.9999999999966137 100.0 INTERPRO IPR005225:Small GTP-binding protein 4 0.35714285714285715 0.9956898679641207 RAB31, RAB39B, RAC1, RAB12 920 167 16659 0.4337151783389742 1.0 1.0 100.0 Annotation Cluster 248 Enrichment Score: 0.08764876818191913 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048610~reproductive cellular process 9 0.8035714285714285 0.6819791249655572 NME5, TRIM36, BCL2, ADAD1, LEFTY2, ZAN, ARSA, MOV10L1, HSD17B4 751 162 13528 1.0007397544015386 1.0 0.9982153013702054 99.9999998671596 GOTERM_BP_FAT GO:0007338~single fertilization 3 0.26785714285714285 0.8530133544484659 TRIM36, ZAN, ARSA 751 60 13528 0.9006657789613849 1.0 0.999817947116123 99.99999999999986 GOTERM_BP_FAT GO:0009566~fertilization 3 0.26785714285714285 0.9382677385131794 TRIM36, ZAN, ARSA 751 79 13528 0.6840499587048493 1.0 0.9999889436378283 100.0 Annotation Cluster 249 Enrichment Score: 0.0875454908172357 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006816~calcium ion transport 8 0.7142857142857143 0.6787978138143902 SRI, TRPC3, BHLHA15, RYR3, PSEN2, TRPC7, CHRNA7, NFATC1 751 142 13528 1.0148346805198702 1.0 0.998161335875217 99.99999984134483 GOTERM_MF_FAT GO:0005262~calcium channel activity 4 0.35714285714285715 0.8244621781921815 TRPC3, GPM6A, RYR3, TRPC7 725 79 12983 0.906713225665648 1.0 0.999873987652327 99.9999999998101 SP_PIR_KEYWORDS calcium channel 3 0.26785714285714285 0.8437916577413527 TRPC3, RYR3, TRPC7 1027 61 19235 0.9211135409516815 1.0 0.9911021668438377 99.99999999983675 SP_PIR_KEYWORDS calcium transport 3 0.26785714285714285 0.9455219973537566 TRPC3, RYR3, TRPC7 1027 85 19235 0.661034423506501 1.0 0.9987662708811499 100.0 Annotation Cluster 250 Enrichment Score: 0.08276129949874672 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:RRM 2 5 0.4464285714285714 0.7959332387063758 CPNE1, HNRNPD, RBM39, MATR3, RBM12, HNRNPA0 1024 101 19113 0.9240118347772278 1.0 0.9999999998913469 99.99999999994003 UP_SEQ_FEATURE domain:RRM 1 5 0.4464285714285714 0.7959332387063758 CPNE1, HNRNPD, RBM39, MATR3, RBM12, HNRNPA0 1024 101 19113 0.9240118347772278 1.0 0.9999999998913469 99.99999999994003 SP_PIR_KEYWORDS rna-binding 26 2.3214285714285716 0.796194330885002 RNMT, TRMT2A, ADAD1, KIAA0430, TLR3, LARP1B, KIAA0020, MAZ, DGCR8, HNRNPD, ZNF74, RBM12, EWSR1, EXOSC9, SSB, HNRNPU, HNRNPA0, BOLL, SLBP, PHAX, AQR, CPNE1, THOC5, RBM39, CPSF4, MATR3, SRP9 1027 540 19235 0.9017815283638069 1.0 0.9843834784409768 99.999999992029 INTERPRO IPR000504:RNA recognition motif, RNP-1 10 0.8928571428571428 0.8291813853741198 TRMT2A, KIAA0430, CPNE1, HNRNPD, SSB, RBM39, MATR3, RBM12, BOLL, EWSR1, HNRNPA0 920 211 16659 0.8581805069029466 1.0 0.9999998274009775 99.99999999997158 INTERPRO IPR012677:Nucleotide-binding, alpha-beta plait 10 0.8928571428571428 0.8371249752826418 TRMT2A, KIAA0430, CPNE1, HNRNPD, SSB, RBM39, MATR3, RBM12, BOLL, EWSR1, HNRNPA0 920 213 16659 0.8501224739742804 1.0 0.9999998737882826 99.99999999998694 SMART SM00360:RRM 10 0.8928571428571428 0.8489118968197544 TRMT2A, KIAA0430, CPNE1, HNRNPD, SSB, RBM39, MATR3, RBM12, BOLL, EWSR1, HNRNPA0 513 211 9079 0.8387609360420535 1.0 0.999858462022554 99.99999999842952 UP_SEQ_FEATURE domain:RRM 5 0.4464285714285714 0.8863312802234018 TRMT2A, KIAA0430, SSB, BOLL, EWSR1 1024 119 19113 0.7842453387605043 1.0 0.9999999999987512 100.0 Annotation Cluster 251 Enrichment Score: 0.08235319907710618 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005913~cell-cell adherens junction 3 0.26785714285714285 0.58808841142091 PTPRM, ITGA6, ABI2 713 35 12782 1.5366058906030855 1.0 0.96200087772668 99.99969800390419 GOTERM_CC_FAT GO:0005912~adherens junction 9 0.8035714285714285 0.6387256491572184 FMN1, ENAH, PTPRM, NF2, ITGA6, ABI2, ABCB1, TRIP6, CTNNA1 713 155 12782 1.040926571053703 1.0 0.9663379755696483 99.99995390591513 GOTERM_CC_FAT GO:0070161~anchoring junction 9 0.8035714285714285 0.7489194145846652 FMN1, ENAH, PTPRM, NF2, ITGA6, ABI2, ABCB1, TRIP6, CTNNA1 713 172 12782 0.9380442936821162 1.0 0.9845763950149569 99.99999974932915 GOTERM_CC_FAT GO:0005925~focal adhesion 3 0.26785714285714285 0.9800492830904385 ENAH, ABCB1, TRIP6 713 102 12782 0.5272667271677254 1.0 0.9999320987198701 100.0 GOTERM_CC_FAT GO:0005924~cell-substrate adherens junction 3 0.26785714285714285 0.9836295140491322 ENAH, ABCB1, TRIP6 713 106 12782 0.5073698695387546 1.0 0.9999560060839989 100.0 GOTERM_CC_FAT GO:0030055~cell-substrate junction 3 0.26785714285714285 0.9878576665994637 ENAH, ABCB1, TRIP6 713 112 12782 0.4801893408134642 1.0 0.9999763631444832 100.0 GOTERM_CC_FAT GO:0016323~basolateral plasma membrane 6 0.5357142857142857 0.9898324744711916 SLC12A6, ENAH, SLC12A2, ITGA6, ABCB1, TRIP6 713 203 12782 0.5298641002079605 1.0 0.9999837307309791 100.0 Annotation Cluster 252 Enrichment Score: 0.08165348632755147 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030324~lung development 5 0.4464285714285714 0.8060673669066607 SP3, PSEN2, BMPR2, LOX, CUX1 751 99 13528 0.9097634130923078 1.0 0.9995551667703416 99.99999999998046 GOTERM_BP_FAT GO:0030323~respiratory tube development 5 0.4464285714285714 0.8242158865674805 SP3, PSEN2, BMPR2, LOX, CUX1 751 102 13528 0.8830056656484164 1.0 0.9996610211697392 99.99999999999662 GOTERM_BP_FAT GO:0060541~respiratory system development 5 0.4464285714285714 0.8563025167109133 SP3, PSEN2, BMPR2, LOX, CUX1 751 108 13528 0.8339497953346156 1.0 0.9998308305815216 99.99999999999991 Annotation Cluster 253 Enrichment Score: 0.07550712931698793 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS metal-binding 160 14.285714285714285 0.4887252163278598 CYP3A4, CYP3A5, CYP3A7, ZAK, CNDP1, CNDP2, DBF4, PDLIM3, LOC727896, RP9, RNF216, RNF212, PLOD3, MIOX, PHOSPHO2, ZNF394, SCD5, LOX, ENOPH1, SPON2, ANKZF1, PPP4C, POLL, F8, ZHX3, UBR3, COLEC12, CDO1, ZNF3, ZNF236, UHRF2, TRIM36, ZNF789, NAPEPLD, CHPF, ATP9B, PRDM6, PRDM5, PDE5A, ZNHIT1, RELN, ZNF519, ERMP1, ADSS, ZNF516, AGFG2, CYP51A1, NEK1, BMPR2, CXXC5, ATF2, PEG10, ZNF695, ANKIB1, ZNF74, OTUD7A, ZNF124, EWSR1, PGGT1B, ZC3H15, ANKMY1, SMYD3, AFG3L2, DAGLB, SALL3, TRIM56, RNF4, FAM170A, RNF152, TRIM58, NDUFV2, ADAM22, PARP1, TRIP6, FTMT, STEAP4, IMPA2, ZNF532, RNPEPL1, ZCWPW1, ZNF12, PHF20, ZKSCAN1, ZKSCAN5, CYP3A43, TRIM4, SAP30, MAZ, DGCR8, P4HA2, GALNTL6, ATP8B1, GATAD1, CDK15, ZNF496, MBLAC1, EGR1, ZCCHC2, ZDHHC4, AIFM3, BRCC3, DMRT3, ZDHHC8, DMRT1, DMRT2, CYB5A, OSGEPL1, ZSWIM2, PPM1F, AQPEP, CHSY3, ZFYVE28, ZFAND2B, CYBRD1, CPSF4, STEAP2, STEAP1, MATR3, PMPCB, INPP1, PHLPP1, GLIS3, THAP7, ADAMTS19, THAP9, COMT, ZNF655, ZNF804B, MPPE1, NPTX2, ZSCAN21, TGM2, RFPL1, ZNF474, ZNF608, KDM3B, RASA4, SCO2, ENOSF1, ZNF804A, EXO1, BRD1, ZNF770, ZNF669, CYP20A1, CYP4V2, GDPD3, MARCH3, DNPEP, ZNF670, ADNP2, MAPK12, ZBED4, SP3, AOX1, CHN1, ARSA, SP5, KDM4C, TSSK2 1027 2972 19235 1.0083073306065964 1.0 0.9280241964805083 99.99449380138763 INTERPRO IPR007087:Zinc finger, C2H2-type 40 3.571428571428571 0.7740107073030884 ZNF519, GLIS3, ZNF516, ZNF532, SLC39A10, ZNF12, PHF20, ZKSCAN1, ZNF655, ZKSCAN5, ATF2, ZNF804B, MAZ, ZNF695, ZSCAN21, SORBS2, ZNF474, ZNF74, ZNF124, ZNF608, ZNF394, ANKZF1, ZNF496, ZNF804A, EGR1, ZNF770, ZHX3, ZNF669, ZNF3, SALL3, ZNF670, ZNF236, ADNP2, ZNF789, FAM170A, PRDM6, SP3, PRDM5, SP5, MATR3 920 784 16659 0.923857586512866 1.0 0.9999987101558157 99.99999999724051 GOTERM_MF_FAT GO:0046872~metal ion binding 220 19.642857142857142 0.8449873063749669 CYP3A4, CYP3A5, CDIPT, CYP3A7, SCN3A, LOC727896, PDLIM3, RP9, RNF216, RNF212, CDH20, PLOD3, CCBE1, ZNF394, SCD5, POLL, SLC12A6, L3MBTL4, SCN2A, F8, ZHX3, UBR3, COLEC12, ZNF236, EIF2AK1, DOC2A, ZNF789, UHRF2, NAPEPLD, RYR3, PRDM6, PRDM5, ZNHIT1, ADD1, ERMP1, ZNF519, ADSS, ZNF516, SCN1A, CRELD2, CYP51A1, NEK1, ZNF74, ZNF124, ZC3H15, TRPC3, TAOK2, PCDH10, TRPC7, ANKMY1, SMYD3, AFG3L2, DAGLB, RNF4, FAM170A, PARP1, STEAP4, ZNF532, RNPEPL1, ZNF12, PHF20, SLC23A1, P4HA2, GATAD1, ZNF496, MBLAC1, KCNG2, ZDHHC4, AIFM3, ZDHHC8, CYB5A, ZSWIM2, LRPAP1, AQPEP, CHSY3, CYBRD1, SGCE, STEAP2, STEAP1, PMPCB, THAP7, THAP9, EPDR1, SLC39A10, CETN1, ZNF655, PLCL1, STAT4, SORBS2, ZSCAN21, RFPL1, ZNF474, RASA4, ACSL6, BRD1, CAPN8, ZNF770, ZNF669, CYP4V2, STAT1, CAPN2, KCNV2, MARCH3, DNPEP, ZNF670, MAPK12, CDH19, AOX1, ARSA, CHN1, LRP2, VLDLR, ZAK, CNDP1, CNDP2, DBF4, OCM2, MIOX, PGRMC2, PHOSPHO2, LOX, ENOPH1, PPP4C, SPON2, ANKZF1, CDO1, ZNF3, PKD2L2, TRIM36, CHPF, ATP9B, PDE5A, RELN, SLC40A1, SRI, AGFG2, BMPR2, SLC38A11, CXXC5, MYL9, ATF2, PEG10, ZNF695, ITGAV, SCN9A, OTUD7A, ANKIB1, EFCAB2, EWSR1, PGGT1B, ADAM29, MYL12B, MYL12A, SLC25A12, SALL3, TRIM56, ZNF316, PLCG1, ITGA6, RNF152, NDUFV2, TRIM58, ADAM22, TRIP6, FTMT, IMPA2, OCM, ZCWPW1, ZKSCAN1, MOV10L1, BUD31, ZKSCAN5, CYP3A43, TRIM4, MAZ, HPSE, GALNTL6, ATP8B1, SCN7A, CDK15, EGR1, ZCCHC2, BRCC3, DMRT3, DMRT1, DMRT2, OSGEPL1, PPM1F, ZFYVE28, ZFAND2B, CPSF4, MATR3, INPP1, PHLPP1, GALNT3, GLIS3, FKBP9, ADAMTS19, GALNT7, SPOCK1, COMT, ZNF804B, MPPE1, NPTX2, TGM2, ZNF608, KDM3B, SCO2, ZNF804A, ENOSF1, EXO1, SLC12A2, CYP20A1, ANXA5, ADNP2, ZBED4, SP3, SP5, KDM4C, TSSK2 725 4140 12983 0.9516108612360487 1.0 0.999912405588563 99.9999999999724 GOTERM_MF_FAT GO:0046914~transition metal ion binding 145 12.946428571428573 0.8647367985448081 CYP3A4, CYP3A5, CDIPT, CYP3A7, CNDP1, CNDP2, DBF4, PDLIM3, LOC727896, RP9, RNF216, RNF212, PLOD3, PGRMC2, MIOX, ZNF394, LOX, SCD5, ANKZF1, PPP4C, POLL, L3MBTL4, F8, ZHX3, UBR3, CDO1, ZNF3, ZNF236, EIF2AK1, UHRF2, TRIM36, ZNF789, NAPEPLD, PRDM6, PRDM5, PDE5A, ZNHIT1, RELN, SLC40A1, ZNF519, ERMP1, ZNF516, CYP51A1, AGFG2, BMPR2, CXXC5, ATF2, PEG10, ZNF695, ANKIB1, ZNF74, OTUD7A, ZNF124, EWSR1, PGGT1B, ZC3H15, ADAM29, ANKMY1, SMYD3, AFG3L2, SALL3, TRIM56, ZNF316, RNF4, FAM170A, RNF152, TRIM58, NDUFV2, ADAM22, PARP1, TRIP6, FTMT, STEAP4, ZNF532, RNPEPL1, ZCWPW1, ZNF12, PHF20, ZKSCAN1, BUD31, ZKSCAN5, CYP3A43, TRIM4, MAZ, P4HA2, GALNTL6, GATAD1, ZNF496, MBLAC1, EGR1, ZDHHC4, ZCCHC2, AIFM3, BRCC3, ZDHHC8, DMRT3, DMRT1, DMRT2, CYB5A, OSGEPL1, ZSWIM2, PPM1F, AQPEP, ZFAND2B, ZFYVE28, CYBRD1, CPSF4, STEAP2, STEAP1, MATR3, PMPCB, PHLPP1, GALNT3, GLIS3, THAP7, ADAMTS19, THAP9, GALNT7, SLC39A10, ZNF655, ZNF804B, SORBS2, ZSCAN21, RFPL1, ZNF474, ZNF608, KDM3B, RASA4, SCO2, ZNF804A, BRD1, ZNF770, ZNF669, CYP20A1, CYP4V2, MARCH3, DNPEP, ZNF670, ADNP2, ZBED4, SP3, AOX1, SP5, CHN1, KDM4C 725 2785 12983 0.9323518850987433 1.0 0.9999445051193372 99.99999999999667 GOTERM_MF_FAT GO:0043169~cation binding 221 19.732142857142858 0.866441593559849 CYP3A4, CYP3A5, CDIPT, CYP3A7, GLB1L, SCN3A, LOC727896, PDLIM3, RP9, RNF216, RNF212, CDH20, PLOD3, CCBE1, ZNF394, SCD5, POLL, SLC12A6, L3MBTL4, SCN2A, F8, ZHX3, UBR3, COLEC12, ZNF236, EIF2AK1, DOC2A, ZNF789, UHRF2, NAPEPLD, RYR3, PRDM6, PRDM5, ZNHIT1, ADD1, ERMP1, ZNF519, ADSS, ZNF516, SCN1A, CRELD2, CYP51A1, NEK1, ZNF74, ZNF124, ZC3H15, TRPC3, TAOK2, PCDH10, TRPC7, ANKMY1, SMYD3, AFG3L2, DAGLB, RNF4, FAM170A, PARP1, STEAP4, ZNF532, RNPEPL1, ZNF12, PHF20, SLC23A1, P4HA2, GATAD1, ZNF496, MBLAC1, KCNG2, ZDHHC4, AIFM3, ZDHHC8, CYB5A, ZSWIM2, LRPAP1, AQPEP, CHSY3, CYBRD1, SGCE, STEAP2, STEAP1, PMPCB, THAP7, THAP9, EPDR1, SLC39A10, CETN1, ZNF655, PLCL1, STAT4, SORBS2, ZSCAN21, RFPL1, ZNF474, RASA4, ACSL6, BRD1, CAPN8, ZNF770, ZNF669, CYP4V2, STAT1, CAPN2, KCNV2, MARCH3, DNPEP, ZNF670, MAPK12, CDH19, AOX1, ARSA, CHN1, LRP2, VLDLR, ZAK, CNDP1, CNDP2, DBF4, OCM2, MIOX, PGRMC2, PHOSPHO2, LOX, ENOPH1, PPP4C, SPON2, ANKZF1, CDO1, ZNF3, PKD2L2, TRIM36, CHPF, ATP9B, PDE5A, RELN, SLC40A1, SRI, AGFG2, BMPR2, SLC38A11, CXXC5, MYL9, ATF2, PEG10, ZNF695, ITGAV, SCN9A, OTUD7A, ANKIB1, EFCAB2, EWSR1, PGGT1B, ADAM29, MYL12B, MYL12A, SLC25A12, SALL3, TRIM56, ZNF316, PLCG1, ITGA6, RNF152, NDUFV2, TRIM58, ADAM22, TRIP6, FTMT, IMPA2, OCM, ZCWPW1, ZKSCAN1, MOV10L1, BUD31, ZKSCAN5, CYP3A43, TRIM4, MAZ, HPSE, GALNTL6, ATP8B1, SCN7A, CDK15, EGR1, ZCCHC2, BRCC3, DMRT3, DMRT1, DMRT2, OSGEPL1, PPM1F, ZFYVE28, ZFAND2B, CPSF4, MATR3, INPP1, PHLPP1, GALNT3, GLIS3, FKBP9, ADAMTS19, GALNT7, SPOCK1, COMT, ZNF804B, MPPE1, NPTX2, TGM2, ZNF608, KDM3B, SCO2, ZNF804A, ENOSF1, EXO1, SLC12A2, CYP20A1, ANXA5, ADNP2, ZBED4, SP3, SP5, KDM4C, TSSK2 725 4179 12983 0.9470152073998894 1.0 0.9999448772077117 99.99999999999726 GOTERM_MF_FAT GO:0043167~ion binding 224 20.0 0.8734988485705207 CYP3A4, CYP3A5, CDIPT, CYP3A7, GLB1L, SCN3A, LOC727896, PDLIM3, RP9, RNF216, RNF212, CDH20, PLOD3, CCBE1, ZNF394, SCD5, POLL, SLC12A6, L3MBTL4, SCN2A, F8, ZHX3, UBR3, COLEC12, ZNF236, EIF2AK1, DOC2A, ZNF789, UHRF2, NAPEPLD, RYR3, PRDM6, PRDM5, ZNHIT1, ADD1, ERMP1, ZNF519, ADSS, ZNF516, SCN1A, CLCN3, CRELD2, CYP51A1, NEK1, ZNF74, ZNF124, ZC3H15, TRPC3, TAOK2, PCDH10, TRPC7, ANKMY1, SMYD3, AFG3L2, DAGLB, RNF4, FAM170A, PARP1, STEAP4, ZNF532, GLRA3, RNPEPL1, ZNF12, PHF20, SLC23A1, P4HA2, GATAD1, ZNF496, MBLAC1, KCNG2, ZDHHC4, AIFM3, ZDHHC8, CLIC2, CYB5A, ZSWIM2, LRPAP1, AQPEP, CHSY3, CYBRD1, SGCE, STEAP2, STEAP1, PMPCB, THAP7, THAP9, EPDR1, SLC39A10, CETN1, ZNF655, PLCL1, STAT4, SORBS2, ZSCAN21, RFPL1, ZNF474, RASA4, ACSL6, BRD1, CAPN8, ZNF770, ZNF669, CYP4V2, STAT1, CAPN2, KCNV2, MARCH3, DNPEP, ZNF670, MAPK12, CDH19, AOX1, ARSA, CHN1, LRP2, VLDLR, ZAK, CNDP1, CNDP2, DBF4, OCM2, MIOX, PGRMC2, PHOSPHO2, LOX, ENOPH1, PPP4C, SPON2, ANKZF1, CDO1, ZNF3, PKD2L2, TRIM36, CHPF, ATP9B, PDE5A, RELN, SLC40A1, SRI, AGFG2, BMPR2, SLC38A11, CXXC5, MYL9, ATF2, PEG10, ZNF695, ITGAV, SCN9A, OTUD7A, ANKIB1, EFCAB2, EWSR1, PGGT1B, ADAM29, MYL12B, MYL12A, SLC25A12, SALL3, TRIM56, ZNF316, PLCG1, ITGA6, RNF152, NDUFV2, TRIM58, ADAM22, TRIP6, FTMT, IMPA2, OCM, ZCWPW1, ZKSCAN1, MOV10L1, BUD31, ZKSCAN5, CYP3A43, TRIM4, MAZ, HPSE, GALNTL6, ATP8B1, SCN7A, CDK15, EGR1, ZCCHC2, BRCC3, DMRT3, DMRT1, DMRT2, OSGEPL1, PPM1F, ZFYVE28, ZFAND2B, CPSF4, MATR3, INPP1, PHLPP1, GALNT3, GLIS3, FKBP9, ADAMTS19, GALNT7, SPOCK1, COMT, ZNF804B, MPPE1, NPTX2, TGM2, ZNF608, KDM3B, SCO2, ZNF804A, ENOSF1, EXO1, SLC12A2, CYP20A1, ANXA5, ADNP2, ZBED4, SP3, SP5, KDM4C, TSSK2 725 4241 12983 0.9458380830806008 1.0 0.9999552362060861 99.99999999999882 SP_PIR_KEYWORDS zinc 105 9.375 0.9114882837741158 CNDP1, DBF4, PDLIM3, LOC727896, RP9, RNF216, RNF212, AZGP1, ZNF394, PPP4C, ANKZF1, UBR3, ZHX3, ZNF3, ZNF236, NAPEPLD, ZNF789, TRIM36, UHRF2, PRDM6, PRDM5, ZNHIT1, RELN, ERMP1, ZNF519, ZNF516, AGFG2, CXXC5, ATF2, AZGP1P1, PEG10, ZNF695, OTUD7A, ZNF74, ANKIB1, ZNF124, EWSR1, PGGT1B, ZC3H15, ANKMY1, SMYD3, AFG3L2, SALL3, TRIM56, RNF4, RNF152, FAM170A, TRIM58, PARP1, TRIP6, ZNF532, HINT1, RNPEPL1, ZNF12, ZCWPW1, ZKSCAN1, PHF20, ZKSCAN5, TRIM4, SAP30, MAZ, GATAD1, ZNF496, MBLAC1, EGR1, ZDHHC4, ZCCHC2, BRCC3, ZDHHC8, DMRT3, DMRT1, DMRT2, OSGEPL1, ZSWIM2, AQPEP, ZFAND2B, ZFYVE28, CPSF4, MATR3, PMPCB, THAP7, GLIS3, THAP9, ADAMTS19, SLC39A10, ZNF655, ZNF804B, ZSCAN21, ZNF474, RFPL1, KDM3B, ZNF608, RASA4, ZNF804A, BRD1, ZNF770, ZNF669, DNPEP, MARCH3, ZNF670, ADNP2, SP3, ZBED4, SP5, CHN1, KDM4C 1027 2189 19235 0.898390776579187 1.0 0.9968846860977991 99.99999999999996 INTERPRO IPR015880:Zinc finger, C2H2-like 37 3.303571428571429 0.9140532036539941 ZNF519, GLIS3, ZNF516, ZNF532, ZNF12, PHF20, ZKSCAN1, ZNF655, ZKSCAN5, ATF2, ZNF804B, MAZ, ZNF695, ZSCAN21, ZNF74, ZNF124, ZNF608, ZNF394, ANKZF1, ZNF496, ZNF804A, EGR1, ZNF770, ZHX3, ZNF669, ZNF3, SALL3, ZNF670, ZNF236, ADNP2, ZNF789, FAM170A, PRDM6, SP3, PRDM5, SP5, MATR3 920 797 16659 0.8406292619060608 1.0 0.999999996283432 100.0 SP_PIR_KEYWORDS zinc-finger 81 7.232142857142858 0.9160101439995905 ZNF532, DBF4, ZNF12, RP9, ZCWPW1, RNF216, ZKSCAN1, PHF20, ZKSCAN5, RNF212, TRIM4, SAP30, MAZ, ZNF394, GATAD1, ANKZF1, ZNF496, EGR1, ZCCHC2, ZDHHC4, ZDHHC8, UBR3, ZHX3, ZSWIM2, ZNF3, ZNF236, ZNF789, TRIM36, UHRF2, PRDM6, ZFYVE28, ZFAND2B, PRDM5, ZNHIT1, CPSF4, MATR3, THAP7, ZNF519, GLIS3, ZNF516, THAP9, AGFG2, CXXC5, ZNF655, ATF2, ZNF804B, PEG10, ZNF695, ZSCAN21, ZNF474, ANKIB1, OTUD7A, ZNF74, RFPL1, ZNF124, KDM3B, ZNF608, RASA4, EWSR1, ZNF804A, BRD1, ZC3H15, ZNF770, ANKMY1, SMYD3, ZNF669, MARCH3, SALL3, TRIM56, ZNF670, ADNP2, RNF4, FAM170A, RNF152, SP3, ZBED4, TRIM58, SP5, CHN1, KDM4C, PARP1 1027 1718 19235 0.8830465669076948 1.0 0.9970371742544665 99.99999999999997 SMART SM00355:ZnF_C2H2 37 3.303571428571429 0.9391711404929445 ZNF519, GLIS3, ZNF516, ZNF532, ZNF12, PHF20, ZKSCAN1, ZNF655, ZKSCAN5, ATF2, ZNF804B, MAZ, ZNF695, ZSCAN21, ZNF74, ZNF124, ZNF608, ZNF394, ANKZF1, ZNF496, ZNF804A, EGR1, ZNF770, ZHX3, ZNF669, ZNF3, SALL3, ZNF670, ZNF236, ADNP2, ZNF789, FAM170A, PRDM6, SP3, PRDM5, SP5, MATR3 513 797 9079 0.8216068541631507 1.0 0.9999838963215142 99.99999999999999 GOTERM_MF_FAT GO:0008270~zinc ion binding 109 9.732142857142858 0.9851594303671477 CNDP1, CNDP2, DBF4, PDLIM3, LOC727896, RP9, RNF216, RNF212, ZNF394, ANKZF1, L3MBTL4, ZHX3, UBR3, ZNF3, ZNF236, NAPEPLD, ZNF789, TRIM36, UHRF2, PRDM6, PDE5A, PRDM5, ZNHIT1, RELN, ZNF519, ERMP1, ZNF516, AGFG2, CXXC5, ATF2, PEG10, ZNF695, ANKIB1, OTUD7A, ZNF74, ZNF124, EWSR1, PGGT1B, ADAM29, ZC3H15, ANKMY1, SMYD3, AFG3L2, SALL3, TRIM56, RNF4, ZNF316, FAM170A, RNF152, TRIM58, ADAM22, PARP1, TRIP6, ZNF532, RNPEPL1, ZNF12, ZCWPW1, ZKSCAN1, PHF20, BUD31, ZKSCAN5, TRIM4, MAZ, GATAD1, ZNF496, MBLAC1, EGR1, ZDHHC4, ZCCHC2, BRCC3, ZDHHC8, DMRT3, DMRT1, DMRT2, OSGEPL1, ZSWIM2, AQPEP, ZFAND2B, ZFYVE28, CPSF4, MATR3, PMPCB, THAP7, GLIS3, THAP9, ADAMTS19, SLC39A10, ZNF655, ZNF804B, ZSCAN21, SORBS2, ZNF474, RFPL1, KDM3B, ZNF608, RASA4, ZNF804A, BRD1, ZNF770, ZNF669, DNPEP, MARCH3, ZNF670, ADNP2, SP3, ZBED4, SP5, CHN1, KDM4C 725 2311 12983 0.8446243602560468 1.0 0.999999942330239 100.0 Annotation Cluster 254 Enrichment Score: 0.0651578831402882 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0051020~GTPase binding 6 0.5357142857142857 0.734201457740898 ALS2, RALBP1, RAPGEF6, RANBP1, DOCK8, PTPRN 725 109 12983 0.9857386902878835 1.0 0.9995280304308835 99.9999998815452 SP_PIR_KEYWORDS guanine-nucleotide releasing factor 5 0.4464285714285714 0.8922798768609899 ALS2, RAPGEF6, RAPGEF4, DOCK8, FBXO8 1027 121 19235 0.7739383746288234 1.0 0.9956756766543882 99.99999999999929 GOTERM_MF_FAT GO:0005085~guanyl-nucleotide exchange factor activity 5 0.4464285714285714 0.9732177236914434 ALS2, RAPGEF6, RAPGEF4, DOCK8, FBXO8 725 152 12983 0.589065335753176 1.0 0.9999997202017132 100.0 Annotation Cluster 255 Enrichment Score: 0.06360303991436515 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS meiosis 3 0.26785714285714285 0.7229115653290054 EXO1, SGOL2, STAG3 1027 47 19235 1.195487787192608 1.0 0.9767730687970544 99.9999992892733 GOTERM_BP_FAT GO:0051327~M phase of meiotic cell cycle 4 0.35714285714285715 0.9143639983310103 EXO1, SGOL2, STAG3, BOLL 751 98 13528 0.7352373705807224 1.0 0.999968433098903 100.0 GOTERM_BP_FAT GO:0007126~meiosis 4 0.35714285714285715 0.9143639983310103 EXO1, SGOL2, STAG3, BOLL 751 98 13528 0.7352373705807224 1.0 0.999968433098903 100.0 GOTERM_BP_FAT GO:0051321~meiotic cell cycle 4 0.35714285714285715 0.9210101820517995 EXO1, SGOL2, STAG3, BOLL 751 100 13528 0.7205326231691079 1.0 0.9999752553272125 100.0 Annotation Cluster 256 Enrichment Score: 0.06256226920750532 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051340~regulation of ligase activity 5 0.4464285714285714 0.6640815420213648 MAD2L1, PSMC2, BTRC, CDC23, NHEJ1 751 81 13528 1.1119330604461541 1.0 0.9979176134042053 99.99999964717706 GOTERM_BP_FAT GO:0051439~regulation of ubiquitin-protein ligase activity during mitotic cell cycle 4 0.35714285714285715 0.7614851350438295 MAD2L1, PSMC2, BTRC, CDC23 751 71 13528 1.0148346805198702 1.0 0.9991492199908315 99.99999999921607 GOTERM_BP_FAT GO:0051351~positive regulation of ligase activity 4 0.35714285714285715 0.777815838030387 PSMC2, BTRC, CDC23, NHEJ1 751 73 13528 0.9870309906426136 1.0 0.9993512875179825 99.99999999977882 GOTERM_BP_FAT GO:0031400~negative regulation of protein modification process 6 0.5357142857142857 0.7961785169486193 MAD2L1, NF2, PSMC2, PSEN2, CDC23, IL2 751 119 13528 0.9082343989526569 1.0 0.9994660172324321 99.99999999995254 GOTERM_BP_FAT GO:0051438~regulation of ubiquitin-protein ligase activity 4 0.35714285714285715 0.8146398250560288 MAD2L1, PSMC2, BTRC, CDC23 751 78 13528 0.9237597732937282 1.0 0.9995999447547695 99.99999999999127 GOTERM_BP_FAT GO:0051436~negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle 3 0.26785714285714285 0.8824262946879619 MAD2L1, PSMC2, CDC23 751 65 13528 0.8313837959643553 1.0 0.9999160304388595 100.0 GOTERM_BP_FAT GO:0031145~anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process 3 0.26785714285714285 0.8824262946879619 MAD2L1, PSMC2, CDC23 751 65 13528 0.8313837959643553 1.0 0.9999160304388595 100.0 GOTERM_BP_FAT GO:0051444~negative regulation of ubiquitin-protein ligase activity 3 0.26785714285714285 0.8925895040129662 MAD2L1, PSMC2, CDC23 751 67 13528 0.8065663692191507 1.0 0.9999351638865164 100.0 GOTERM_BP_FAT GO:0051352~negative regulation of ligase activity 3 0.26785714285714285 0.8925895040129662 MAD2L1, PSMC2, CDC23 751 67 13528 0.8065663692191507 1.0 0.9999351638865164 100.0 GOTERM_BP_FAT GO:0051437~positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle 3 0.26785714285714285 0.8973593984355941 PSMC2, BTRC, CDC23 751 68 13528 0.7947050990835749 1.0 0.999943358914267 100.0 GOTERM_BP_FAT GO:0051443~positive regulation of ubiquitin-protein ligase activity 3 0.26785714285714285 0.9063129156497588 PSMC2, BTRC, CDC23 751 70 13528 0.7719992391097584 1.0 0.9999566347425088 100.0 GOTERM_BP_FAT GO:0031396~regulation of protein ubiquitination 4 0.35714285714285715 0.9210101820517995 MAD2L1, PSMC2, BTRC, CDC23 751 100 13528 0.7205326231691079 1.0 0.9999752553272125 100.0 GOTERM_BP_FAT GO:0031397~negative regulation of protein ubiquitination 3 0.26785714285714285 0.9220707661916964 MAD2L1, PSMC2, CDC23 751 74 13528 0.7302695505092309 1.0 0.9999762345299629 100.0 GOTERM_BP_FAT GO:0031398~positive regulation of protein ubiquitination 3 0.26785714285714285 0.9512361294167178 PSMC2, BTRC, CDC23 751 84 13528 0.6433326992581321 1.0 0.9999947764037681 100.0 GOTERM_BP_FAT GO:0043161~proteasomal ubiquitin-dependent protein catabolic process 3 0.26785714285714285 0.979541791822888 MAD2L1, PSMC2, CDC23 751 102 13528 0.5298033993890499 1.0 0.9999997137899738 100.0 GOTERM_BP_FAT GO:0010498~proteasomal protein catabolic process 3 0.26785714285714285 0.979541791822888 MAD2L1, PSMC2, CDC23 751 102 13528 0.5298033993890499 1.0 0.9999997137899738 100.0 Annotation Cluster 257 Enrichment Score: 0.05918167367621153 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0015931~nucleobase, nucleoside, nucleotide and nucleic acid transport 6 0.5357142857142857 0.7578422643716869 PHAX, SLC23A1, SEH1L, THOC5, SP9, MVP 751 113 13528 0.9564592342952759 1.0 0.9991058771492908 99.99999999897264 SP_PIR_KEYWORDS mRNA transport 4 0.35714285714285715 0.76260508592015 SEH1L, AHCTF1, THOC5, MVP 1027 74 19235 1.0123950630279746 1.0 0.9806628708371828 99.99999992585387 GOTERM_BP_FAT GO:0050657~nucleic acid transport 4 0.35714285714285715 0.9108535373752065 PHAX, SEH1L, THOC5, MVP 751 97 13528 0.7428171372877401 1.0 0.9999637551849081 100.0 GOTERM_BP_FAT GO:0050658~RNA transport 4 0.35714285714285715 0.9108535373752065 PHAX, SEH1L, THOC5, MVP 751 97 13528 0.7428171372877401 1.0 0.9999637551849081 100.0 GOTERM_BP_FAT GO:0051236~establishment of RNA localization 4 0.35714285714285715 0.9108535373752065 PHAX, SEH1L, THOC5, MVP 751 97 13528 0.7428171372877401 1.0 0.9999637551849081 100.0 GOTERM_BP_FAT GO:0006403~RNA localization 4 0.35714285714285715 0.9210101820517995 PHAX, SEH1L, THOC5, MVP 751 100 13528 0.7205326231691079 1.0 0.9999752553272125 100.0 GOTERM_BP_FAT GO:0051028~mRNA transport 3 0.26785714285714285 0.9577224893073373 SEH1L, THOC5, MVP 751 87 13528 0.6211488130768171 1.0 0.9999965947186146 100.0 Annotation Cluster 258 Enrichment Score: 0.057410288674847314 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:PHD-type 3 0.26785714285714285 0.7748464935375164 BRD1, UHRF2, PHF20 1024 52 19113 1.0768291766826923 1.0 0.9999999996886777 99.99999999965792 INTERPRO IPR001965:Zinc finger, PHD-type 4 0.35714285714285715 0.8801579223529086 BRD1, UHRF2, KDM4C, PHF20 920 90 16659 0.8047826086956522 1.0 0.9999999779642976 99.99999999999991 SMART SM00249:PHD 4 0.35714285714285715 0.889819830596478 BRD1, UHRF2, KDM4C, PHF20 513 90 9079 0.7865713666883257 1.0 0.9999150937613527 99.9999999999754 INTERPRO IPR019786:Zinc finger, PHD-type, conserved site 4 0.35714285714285715 0.8933659130829323 BRD1, UHRF2, KDM4C, PHF20 920 93 16659 0.7788218793828893 1.0 0.9999999894640913 99.99999999999999 INTERPRO IPR019787:Zinc finger, PHD-finger 3 0.26785714285714285 0.9524470131957239 BRD1, UHRF2, PHF20 920 85 16659 0.6390920716112533 1.0 0.9999999998957648 100.0 Annotation Cluster 259 Enrichment Score: 0.05322828684779388 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013098:Immunoglobulin I-set 8 0.7142857142857143 0.6441167109466378 PTPRD, FGFR3, ALPK2, SPEG, OBSL1, MFAP3L, MYOM1, MYOT 920 138 16659 1.0497164461247637 1.0 0.999983770700269 99.99999537708331 INTERPRO IPR003598:Immunoglobulin subtype 2 11 0.9821428571428571 0.7002283263543915 PTPRD, FGFR3, ALPK2, SPEG, OBSL1, MALT1, MFAP3L, HEPACAM2, MYOM1, CD226, MYOT 920 205 16659 0.971627783669141 1.0 0.9999948050067756 99.99999972027244 SMART SM00408:IGc2 11 0.9821428571428571 0.727175266610174 PTPRD, FGFR3, ALPK2, SPEG, OBSL1, MALT1, MFAP3L, HEPACAM2, MYOM1, CD226, MYOT 513 205 9079 0.9496410402700517 1.0 0.9991464921049686 99.99999624664873 INTERPRO IPR003599:Immunoglobulin subtype 15 1.3392857142857142 0.8770084987639986 FGFR3, PTPRM, ALPK2, MALT1, PTPRT, HEPACAM2, PDCD1LG2, MYOT, SPEG, VSTM2L, CD274, OBSL1, MYOM1, PILRB, PILRA 920 330 16659 0.8230731225296443 1.0 0.9999999755334176 99.99999999999987 SMART SM00409:IG 15 1.3392857142857142 0.8970666465910532 FGFR3, PTPRM, ALPK2, MALT1, PTPRT, HEPACAM2, PDCD1LG2, MYOT, SPEG, VSTM2L, CD274, OBSL1, MYOM1, PILRB, PILRA 513 330 9079 0.8044479886585149 1.0 0.9999262219529167 99.99999999998995 INTERPRO IPR013151:Immunoglobulin 8 0.7142857142857143 0.9337344129326878 PTPRD, PTPRM, FGFR3, CD274, OBSL1, MALT1, HEPACAM2, MYOM1 920 202 16659 0.717133017649591 1.0 0.9999999992126214 100.0 UP_SEQ_FEATURE domain:Ig-like C2-type 1 7 0.625 0.9447296453758218 PTPRD, FGFR3, MALT1, HEPACAM2, MYOM1, CD226, MYOT 1024 190 19113 0.687659333881579 1.0 0.9999999999999973 100.0 UP_SEQ_FEATURE domain:Ig-like C2-type 2 7 0.625 0.9464691141343101 PTPRD, FGFR3, MALT1, HEPACAM2, MYOM1, CD226, MYOT 1024 191 19113 0.6840590232329843 1.0 0.9999999999999971 100.0 SP_PIR_KEYWORDS Immunoglobulin domain 17 1.5178571428571428 0.9820107678617399 PTPRD, FGFR3, PTPRM, ALPK2, MALT1, PTPRT, HEPACAM2, PDCD1LG2, MYOT, SPEG, CD274, VSTM2L, MYOM1, MFAP3L, CD226, PILRB, PILRA 1027 470 19235 0.6774430794091445 1.0 0.9998456878478256 100.0 INTERPRO IPR007110:Immunoglobulin-like 19 1.6964285714285714 0.9829426811861381 PTPRD, FGFR3, PTPRM, ALPK2, MALT1, PTPRT, HEPACAM2, PDCD1LG2, MYOT, AZGP1P1, AZGP1, SPEG, CD274, VSTM2L, OBSL1, MYOM1, MFAP3L, CD226, PILRB, PILRA 920 501 16659 0.6867156990367091 1.0 0.9999999999998244 100.0 UP_SEQ_FEATURE domain:Ig-like C2-type 3 3 0.26785714285714285 0.9905379196107927 PTPRD, FGFR3, MYOM1 1024 122 19113 0.4589763703893443 1.0 1.0 100.0 INTERPRO IPR013783:Immunoglobulin-like fold 20 1.7857142857142856 0.9920375945784835 PTPRD, FGFR3, PTPRM, ALPK2, MALT1, HEPACAM2, PDCD1LG2, MYOT, AZGP1P1, AZGP1, SPEG, CD274, VSTM2L, TGM2, OBSL1, MFAP3L, MYOM1, CD226, PILRB, PILRA, NFATC1 920 553 16659 0.6548863904395 1.0 0.9999999999999984 100.0 INTERPRO IPR013106:Immunoglobulin V-set 7 0.625 0.9946708345547943 VSTM2L, OBSL1, HEPACAM2, MYOM1, CD226, PILRB, PILRA 920 249 16659 0.509049240440021 1.0 0.9999999999999999 100.0 Annotation Cluster 260 Enrichment Score: 0.04721974662510631 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0031420~alkali metal ion binding 12 1.0714285714285714 0.7323310506599846 SLC12A6, INPP1, SCN1A, SLC23A1, SLC12A2, SCN3A, SCN2A, SCN9A, SLC38A11, SCN7A, KCNV2, KCNG2 725 228 12983 0.9425045372050818 1.0 0.999533005442974 99.99999986793324 GOTERM_BP_FAT GO:0006813~potassium ion transport 7 0.625 0.8846595740479968 SLC12A6, SLC12A2, VPS4B, KCTD18, KCTD13, KCNV2, KCNG2 751 160 13528 0.7880825565912117 1.0 0.9999204533481897 100.0 SP_PIR_KEYWORDS potassium transport 4 0.35714285714285715 0.9487277766065749 SLC12A6, SLC12A2, KCNV2, KCNG2 1027 115 19235 0.6514542144701748 1.0 0.9988963883202558 100.0 SP_PIR_KEYWORDS potassium 4 0.35714285714285715 0.967262865295793 SLC12A6, SLC12A2, KCNV2, KCNG2 1027 126 19235 0.59458122749262 1.0 0.99950851462121 100.0 GOTERM_MF_FAT GO:0030955~potassium ion binding 4 0.35714285714285715 0.9766332492191441 SLC12A6, SLC12A2, KCNV2, KCNG2 725 128 12983 0.5596120689655172 1.0 0.9999998020466789 100.0 Annotation Cluster 261 Enrichment Score: 0.04478322324908217 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005773~vacuole 12 1.0714285714285714 0.8369208969710236 MAP1LC3C, DOC2A, ATG9A, MFSD8, EPDR1, HPSE, HPS4, ARSA, VPS4B, LRP2, SP9, DNPEP 713 252 12782 0.8536699392239363 1.0 0.9927078415059081 99.99999999948312 GOTERM_CC_FAT GO:0000323~lytic vacuole 9 0.8035714285714285 0.9074829289840379 DOC2A, MFSD8, EPDR1, HPSE, HPS4, ARSA, VPS4B, LRP2, SP9 713 211 12782 0.7646616991152795 1.0 0.9977916391971549 99.99999999999984 GOTERM_CC_FAT GO:0005764~lysosome 9 0.8035714285714285 0.9074829289840379 DOC2A, MFSD8, EPDR1, HPSE, HPS4, ARSA, VPS4B, LRP2, SP9 713 211 12782 0.7646616991152795 1.0 0.9977916391971549 99.99999999999984 SP_PIR_KEYWORDS lysosome 5 0.4464285714285714 0.9605185729535204 DOC2A, MFSD8, HPSE, ARSA, SP9 1027 149 19235 0.6285002908059574 1.0 0.9993164337391937 100.0 Annotation Cluster 262 Enrichment Score: 0.042461874093663664 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006469~negative regulation of protein kinase activity 4 0.35714285714285715 0.8679166922602746 NF2, ZFYVE28, PRKRIP1, CRIPAK 751 87 13528 0.8281984174357563 1.0 0.9998715822665779 99.99999999999997 GOTERM_BP_FAT GO:0033673~negative regulation of kinase activity 4 0.35714285714285715 0.8824103161817177 NF2, ZFYVE28, PRKRIP1, CRIPAK 751 90 13528 0.800591803521231 1.0 0.9999172246355599 100.0 GOTERM_BP_FAT GO:0051348~negative regulation of transferase activity 4 0.35714285714285715 0.9072129778687354 NF2, ZFYVE28, PRKRIP1, CRIPAK 751 96 13528 0.750554815801154 1.0 0.9999577260106635 100.0 GOTERM_BP_FAT GO:0043086~negative regulation of catalytic activity 10 0.8928571428571428 0.973407373237843 GNAL, CHRM5, MAD2L1, NF2, GALR1, PSMC2, ZFYVE28, PRKRIP1, CDC23, CRIPAK 751 277 13528 0.6503002014161623 1.0 0.9999993260323311 100.0 Annotation Cluster 263 Enrichment Score: 0.04140693301767174 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0019724~B cell mediated immunity 3 0.26785714285714285 0.8248094987335071 EXO1, SLA2, HSPD1 751 56 13528 0.9649990488871979 1.0 0.999661782349352 99.99999999999682 GOTERM_BP_FAT GO:0002449~lymphocyte mediated immunity 3 0.26785714285714285 0.9063129156497588 EXO1, SLA2, HSPD1 751 70 13528 0.7719992391097584 1.0 0.9999566347425088 100.0 GOTERM_BP_FAT GO:0002460~adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 3 0.26785714285714285 0.9322137595414544 EXO1, SLA2, HSPD1 751 77 13528 0.7018174900997803 1.0 0.9999853078530916 100.0 GOTERM_BP_FAT GO:0002250~adaptive immune response 3 0.26785714285714285 0.9322137595414544 EXO1, SLA2, HSPD1 751 77 13528 0.7018174900997803 1.0 0.9999853078530916 100.0 GOTERM_BP_FAT GO:0002443~leukocyte mediated immunity 3 0.26785714285714285 0.955657988223847 EXO1, SLA2, HSPD1 751 86 13528 0.6283714736939894 1.0 0.9999960281358455 100.0 Annotation Cluster 264 Enrichment Score: 0.04105490281902625 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0051020~GTPase binding 6 0.5357142857142857 0.734201457740898 ALS2, RALBP1, RAPGEF6, RANBP1, DOCK8, PTPRN 725 109 12983 0.9857386902878835 1.0 0.9995280304308835 99.9999998815452 GOTERM_MF_FAT GO:0017016~Ras GTPase binding 4 0.35714285714285715 0.8893258018912403 ALS2, RALBP1, RAPGEF6, RANBP1 725 91 12983 0.7871466464569913 1.0 0.9999704216562441 99.99999999999986 GOTERM_BP_FAT GO:0043087~regulation of GTPase activity 5 0.4464285714285714 0.9154435213539533 ALS2, RALBP1, AGFG2, ALS2CR12, RAPGEF6 751 123 13528 0.7322486007816137 1.0 0.9999691133190486 100.0 GOTERM_MF_FAT GO:0031267~small GTPase binding 4 0.35714285714285715 0.9260188414417576 ALS2, RALBP1, RAPGEF6, RANBP1 725 101 12983 0.709211334926596 1.0 0.9999916855353583 100.0 GOTERM_BP_FAT GO:0046578~regulation of Ras protein signal transduction 8 0.7142857142857143 0.9502358547498732 ALS2, RALBP1, AGFG2, RAC1, SH2B2, ITPKB, FBXO8, EPO 751 210 13528 0.6862215458753408 1.0 0.9999944305111258 100.0 GOTERM_BP_FAT GO:0032318~regulation of Ras GTPase activity 3 0.26785714285714285 0.9814544343836827 ALS2, RALBP1, AGFG2 751 104 13528 0.519614872477722 1.0 0.9999998000363136 100.0 GOTERM_MF_FAT GO:0005083~small GTPase regulator activity 6 0.5357142857142857 0.9995087754650923 ALS2, RALBP1, AGFG2, KRIT1, RANBP1, FBXO8 725 274 12983 0.39213692423861063 1.0 0.999999999999822 100.0 Annotation Cluster 265 Enrichment Score: 0.04055441059425397 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY hsa05012:Parkinson's disease 7 0.625 0.7759411684861249 NDUFB3, SEPT5, SNCAIP, SLC25A31, NDUFV2, UBE2L3, ATP5G3 301 128 5085 0.9238735465116279 1.0 0.9612635136285875 99.9999986485044 GOTERM_CC_FAT GO:0044455~mitochondrial membrane part 5 0.4464285714285714 0.9231930973651838 NDUFB3, FIS1, ATP5J2, NDUFV2, ATP5G3 713 125 12782 0.7170827489481066 1.0 0.9985325270188464 99.99999999999999 GOTERM_BP_FAT GO:0006119~oxidative phosphorylation 3 0.26785714285714285 0.9751270230663918 NDUFB3, NDUFV2, ATP5G3 751 98 13528 0.5514280279355418 1.0 0.9999994485253487 100.0 KEGG_PATHWAY hsa00190:Oxidative phosphorylation 4 0.35714285714285715 0.9853711042677369 NDUFB3, ATP5J2, NDUFV2, ATP5G3 301 130 5085 0.5198057756197292 1.0 0.999341738065084 100.0 Annotation Cluster 266 Enrichment Score: 0.031176729704147504 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS plasma 5 0.4464285714285714 0.7377258162928657 F11, KLKB1, F8, SERPIND1, HGFAC 1027 93 19235 1.0069520788181467 1.0 0.9789853347298164 99.99999968168706 SP_PIR_KEYWORDS serine proteinase 3 0.26785714285714285 0.7909412049807456 F11, KLKB1, HGFAC 1027 54 19235 1.0405171481120847 1.0 0.9839439930219989 99.99999998843667 GOTERM_MF_FAT GO:0017171~serine hydrolase activity 8 0.7142857142857143 0.8810339922908966 F11, ACHE, SEC11C, KLKB1, SERPINE1, SERPINB2, RELN, HGFAC 725 180 12983 0.7958927203065134 1.0 0.9999627415700235 99.99999999999955 GOTERM_MF_FAT GO:0008236~serine-type peptidase activity 7 0.625 0.9367586127621829 F11, SEC11C, KLKB1, SERPINE1, SERPINB2, RELN, HGFAC 725 178 12983 0.7042309182487408 1.0 0.9999943786657383 100.0 GOTERM_MF_FAT GO:0004252~serine-type endopeptidase activity 5 0.4464285714285714 0.9753007503032762 F11, KLKB1, SERPINE1, SERPINB2, HGFAC 725 154 12983 0.5814151365875504 1.0 0.9999997687508754 100.0 SP_PIR_KEYWORDS Serine protease 4 0.35714285714285715 0.9784466140241752 F11, KLKB1, RELN, HGFAC 1027 136 19235 0.5508620195887508 1.0 0.9997856619102897 100.0 UP_SEQ_FEATURE domain:Peptidase S1 3 0.26785714285714285 0.979706050581649 F11, KLKB1, HGFAC 1024 106 19113 0.5282558225235849 1.0 1.0 100.0 INTERPRO IPR001314:Peptidase S1A, chymotrypsin 3 0.26785714285714285 0.9809094711753488 F11, KLKB1, HGFAC 920 104 16659 0.5223348662207358 1.0 0.9999999999997119 100.0 INTERPRO IPR018114:Peptidase S1/S6, chymotrypsin/Hap, active site 3 0.26785714285714285 0.981819226800332 F11, KLKB1, HGFAC 920 105 16659 0.517360248447205 1.0 0.9999999999997629 100.0 INTERPRO IPR001254:Peptidase S1 and S6, chymotrypsin/Hap 3 0.26785714285714285 0.9894214539653663 F11, KLKB1, HGFAC 920 116 16659 0.46830022488755624 1.0 0.9999999999999905 100.0 SMART SM00020:Tryp_SPc 3 0.26785714285714285 0.9908579733444612 F11, KLKB1, HGFAC 513 116 9079 0.4577031659608792 1.0 0.9999999679776315 100.0 UP_SEQ_FEATURE active site:Charge relay system 5 0.4464285714285714 0.9940197787084866 F11, ACHE, KLKB1, HGFAC, DAGLB 1024 196 19113 0.47614895567602045 1.0 1.0 100.0 Annotation Cluster 267 Enrichment Score: 0.031109195764698224 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043009~chordate embryonic development 14 1.25 0.9287547171685212 ALS2, HTT, TBX1, CAPN2, DLX2, PLK4, DLX1, PLCG1, HAND2, SP3, PSEN2, CASP8, TGIF1, ADD1 751 331 13528 0.7618925018404464 1.0 0.9999831002568376 100.0 GOTERM_BP_FAT GO:0001701~in utero embryonic development 7 0.625 0.9300980044690096 ALS2, PLK4, PLCG1, HAND2, SP3, CAPN2, ADD1 751 176 13528 0.7164386878101925 1.0 0.999983859081926 100.0 GOTERM_BP_FAT GO:0009792~embryonic development ending in birth or egg hatching 14 1.25 0.9337759141783669 ALS2, HTT, TBX1, CAPN2, DLX2, PLK4, DLX1, PLCG1, HAND2, SP3, PSEN2, CASP8, TGIF1, ADD1 751 334 13528 0.7550491560155322 1.0 0.9999864323259183 100.0 Annotation Cluster 268 Enrichment Score: 0.030498412934872505 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006367~transcription initiation from RNA polymerase II promoter 3 0.26785714285714285 0.8973593984355941 MAZ, TAF6, POLR2J 751 68 13528 0.7947050990835749 1.0 0.999943358914267 100.0 GOTERM_BP_FAT GO:0006352~transcription initiation 3 0.26785714285714285 0.9488702901463287 MAZ, TAF6, POLR2J 751 83 13528 0.651083695634736 1.0 0.9999940024586048 100.0 GOTERM_BP_FAT GO:0006366~transcription from RNA polymerase II promoter 9 0.8035714285714285 0.9513306667068645 MAZ, TAF1A, TAF6, POLR2J, BMPR2, PARP1, STAT1, FEV, NFATC1 751 234 13528 0.692819829970296 1.0 0.9999947244240649 100.0 Annotation Cluster 269 Enrichment Score: 0.029436429580332286 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS chemotaxis 3 0.26785714285714285 0.9027371983709693 TYMP, ECSCR, SERPIND1 1027 72 19235 0.7803878610840635 1.0 0.996282938037983 99.99999999999984 GOTERM_BP_FAT GO:0007626~locomotory behavior 11 0.9821428571428571 0.9430675537686716 ALS2, EPHA4, MAPK1, TYMP, SCN1A, RALBP1, HTT, ECSCR, RAC1, RELN, SERPIND1 751 274 13528 0.7231623042755645 1.0 0.999991784183585 100.0 GOTERM_BP_FAT GO:0042330~taxis 6 0.5357142857142857 0.946400737399643 MAPK1, TYMP, RALBP1, ECSCR, RAC1, SERPIND1 751 160 13528 0.6754993342210386 1.0 0.9999928668798298 100.0 GOTERM_BP_FAT GO:0006935~chemotaxis 6 0.5357142857142857 0.946400737399643 MAPK1, TYMP, RALBP1, ECSCR, RAC1, SERPIND1 751 160 13528 0.6754993342210386 1.0 0.9999928668798298 100.0 Annotation Cluster 270 Enrichment Score: 0.028588592927491885 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006928~cell motion 22 1.9642857142857142 0.885975553754229 ACTB, PTPRM, TAOK2, ABI2, SPOCK1, TBX1, DNAH7, SRC, ELMO1, LAMA1, SEMA6A, VEGFC, EPHA4, ARPC1B, NDE1, ITGA6, SERPINB5, RAC1, JAK2, RELN, SPON2, GFRA3 751 475 13528 0.8343009320905459 1.0 0.9999232014678301 100.0 GOTERM_BP_FAT GO:0016477~cell migration 11 0.9821428571428571 0.9461337111808024 LAMA1, VEGFC, NDE1, TAOK2, ITGA6, RAC1, ABI2, TBX1, RELN, SRC, GFRA3 751 276 13528 0.7179219977228429 1.0 0.9999928472122103 100.0 GOTERM_BP_FAT GO:0051674~localization of cell 12 1.0714285714285714 0.957493173465491 LAMA1, VEGFC, NDE1, TAOK2, ITGA6, RAC1, ABI2, TBX1, RELN, DNAH7, SRC, GFRA3 751 307 13528 0.7041035405561314 1.0 0.999996583148598 100.0 GOTERM_BP_FAT GO:0048870~cell motility 12 1.0714285714285714 0.957493173465491 LAMA1, VEGFC, NDE1, TAOK2, ITGA6, RAC1, ABI2, TBX1, RELN, DNAH7, SRC, GFRA3 751 307 13528 0.7041035405561314 1.0 0.999996583148598 100.0 Annotation Cluster 271 Enrichment Score: 0.021797546328025084 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR007087:Zinc finger, C2H2-type 40 3.571428571428571 0.7740107073030884 ZNF519, GLIS3, ZNF516, ZNF532, SLC39A10, ZNF12, PHF20, ZKSCAN1, ZNF655, ZKSCAN5, ATF2, ZNF804B, MAZ, ZNF695, ZSCAN21, SORBS2, ZNF474, ZNF74, ZNF124, ZNF608, ZNF394, ANKZF1, ZNF496, ZNF804A, EGR1, ZNF770, ZHX3, ZNF669, ZNF3, SALL3, ZNF670, ZNF236, ADNP2, ZNF789, FAM170A, PRDM6, SP3, PRDM5, SP5, MATR3 920 784 16659 0.923857586512866 1.0 0.9999987101558157 99.99999999724051 UP_SEQ_FEATURE zinc finger region:C2H2-type 1 24 2.142857142857143 0.899653288225313 EGR1, GLIS3, ZNF516, ZNF770, ZHX3, ZNF12, ZKSCAN1, ZNF669, ZNF655, ZKSCAN5, ZNF3, SALL3, ZNF670, ADNP2, ZNF236, MAZ, ZNF789, ZSCAN21, SP3, PRDM5, SP5, ZNF74, ZNF124, ZNF394 1024 542 19113 0.8264961946494465 1.0 0.9999999999995483 100.0 INTERPRO IPR015880:Zinc finger, C2H2-like 37 3.303571428571429 0.9140532036539941 ZNF519, GLIS3, ZNF516, ZNF532, ZNF12, PHF20, ZKSCAN1, ZNF655, ZKSCAN5, ATF2, ZNF804B, MAZ, ZNF695, ZSCAN21, ZNF74, ZNF124, ZNF608, ZNF394, ANKZF1, ZNF496, ZNF804A, EGR1, ZNF770, ZHX3, ZNF669, ZNF3, SALL3, ZNF670, ZNF236, ADNP2, ZNF789, FAM170A, PRDM6, SP3, PRDM5, SP5, MATR3 920 797 16659 0.8406292619060608 1.0 0.999999996283432 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 5 23 2.0535714285714284 0.9265200575489232 GLIS3, ZNF519, ZNF516, ZNF532, ZNF770, ZNF12, ZKSCAN1, ZNF669, ZNF655, ZKSCAN5, ZNF3, SALL3, ZNF670, ZNF236, MAZ, ZNF789, ZNF695, ZSCAN21, PRDM5, ZNF74, ZNF124, ZNF394, ZNF496 1024 538 19113 0.7979477666124536 1.0 0.9999999999999637 100.0 SMART SM00355:ZnF_C2H2 37 3.303571428571429 0.9391711404929445 ZNF519, GLIS3, ZNF516, ZNF532, ZNF12, PHF20, ZKSCAN1, ZNF655, ZKSCAN5, ATF2, ZNF804B, MAZ, ZNF695, ZSCAN21, ZNF74, ZNF124, ZNF608, ZNF394, ANKZF1, ZNF496, ZNF804A, EGR1, ZNF770, ZHX3, ZNF669, ZNF3, SALL3, ZNF670, ZNF236, ADNP2, ZNF789, FAM170A, PRDM6, SP3, PRDM5, SP5, MATR3 513 797 9079 0.8216068541631507 1.0 0.9999838963215142 99.99999999999999 UP_SEQ_FEATURE zinc finger region:C2H2-type 6 20 1.7857142857142856 0.9453355905904653 ZNF519, ZNF516, ZNF532, ZNF770, ZNF12, ZKSCAN1, ZNF669, ZNF655, ZKSCAN5, ZNF3, SALL3, ZNF670, ZNF236, ZNF789, ZNF695, ZSCAN21, PRDM5, ZNF74, ZNF124, ZNF394 1024 488 19113 0.7649606173155739 1.0 0.9999999999999972 100.0 UP_SEQ_FEATURE domain:KRAB 13 1.1607142857142858 0.9455900326067298 ZNF519, ZNF12, ZNF669, ZKSCAN1, ZKSCAN5, ZNF3, ZNF670, ZNF789, ZNF695, ZNF74, ZNF124, ZNF394, ZNF496 1024 332 19113 0.7308599632906627 1.0 0.999999999999997 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 3 26 2.3214285714285716 0.9492759928421374 GLIS3, ZNF519, ZNF516, ZNF532, ZNF12, ZKSCAN1, ZNF655, ZKSCAN5, MAZ, ZSCAN21, ZNF74, ZNF124, ZNF394, ZNF496, EGR1, ZNF770, ZNF669, ZNF3, SALL3, ZNF670, ADNP2, ZNF236, ZNF789, PRDM6, SP3, SP5 1024 622 19113 0.7802106360530546 1.0 0.9999999999999982 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 2 25 2.232142857142857 0.9562203036544477 ZNF519, ZNF516, ZNF12, ZKSCAN1, ZNF655, ZKSCAN5, MAZ, ZSCAN21, ZNF74, ZNF124, ZNF394, ZNF496, EGR1, ZNF770, ZHX3, ZNF669, ZNF3, SALL3, ZNF670, ADNP2, ZNF236, ZNF789, SP3, PRDM6, SP5 1024 608 19113 0.7674769351356907 1.0 0.9999999999999996 100.0 INTERPRO IPR001909:Krueppel-associated box 14 1.25 0.9589345646243775 ZNF519, ZNF12, ZNF669, ZKSCAN1, ZNF655, ZKSCAN5, ZNF3, ZNF670, ZNF789, ZNF695, ZNF74, ZNF124, ZNF394, ZNF496 920 355 16659 0.7141028781383956 1.0 0.9999999999604532 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 8 16 1.4285714285714286 0.9637471586213961 ZNF519, ZNF516, ZNF532, ZNF770, ZNF12, ZNF669, ZKSCAN5, ZNF3, SALL3, ZNF670, ZNF236, ZNF789, ZNF695, PRDM5, ZNF74, ZNF124 1024 417 19113 0.7161645683453237 1.0 0.9999999999999999 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 4 23 2.0535714285714284 0.9648101474421166 GLIS3, ZNF519, ZNF516, ZNF532, ZNF770, ZNF12, ZKSCAN1, ZNF669, ZNF655, ZKSCAN5, ZNF3, SALL3, ZNF670, ADNP2, ZNF236, MAZ, ZNF789, ZSCAN21, PRDM5, ZNF74, ZNF124, ZNF394, ZNF496 1024 575 19113 0.7466015625000001 1.0 1.0 100.0 SMART SM00349:KRAB 14 1.25 0.9678290352268754 ZNF519, ZNF12, ZNF669, ZKSCAN1, ZNF655, ZKSCAN5, ZNF3, ZNF670, ZNF789, ZNF695, ZNF74, ZNF124, ZNF394, ZNF496 513 355 9079 0.6979436070614721 1.0 0.999998413529965 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 7 17 1.5178571428571428 0.9723191203531917 ZNF519, ZNF516, ZNF532, ZNF12, ZNF669, ZKSCAN5, ZNF3, SALL3, ZNF670, ZNF236, ZNF789, ZNF695, ZSCAN21, PRDM5, ZNF74, ZNF124, ZNF394 1024 451 19113 0.7035602307372506 1.0 1.0 100.0 INTERPRO IPR013087:Zinc finger, C2H2-type/integrase, DNA-binding 25 2.232142857142857 0.9776157308806736 GLIS3, ZNF519, ZNF12, ZKSCAN1, ZNF655, ZKSCAN5, MAZ, ZNF695, ZSCAN21, ZNF74, ZNF124, ZNF394, ZNF496, EGR1, ZNF770, ZNF669, ZNF3, SALL3, ZNF670, ZNF236, ZNF789, SP3, PRDM6, PRDM5, SP5 920 621 16659 0.7289697542533081 1.0 0.9999999999992121 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 12 6 0.5357142857142857 0.9979352182323437 ZNF236, ZNF695, ZNF532, PRDM5, ZNF74, ZKSCAN5 1024 252 19113 0.4444056919642857 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 9 10 0.8928571428571428 0.9985603460492414 SALL3, ZNF519, ZNF236, ZNF695, ZNF532, ZNF770, PRDM5, ZNF74, ZNF669, ZKSCAN5 1024 376 19113 0.49641061336436165 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 13 4 0.35714285714285715 0.9988386416923242 ZNF236, ZNF695, PRDM5, ZKSCAN5 1024 201 19113 0.37144356343283585 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 10 8 0.7142857142857143 0.9991618035988671 ZNF519, ZNF516, ZNF236, ZNF695, ZNF770, PRDM5, ZNF74, ZKSCAN5 1024 334 19113 0.4470668038922156 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 11 6 0.5357142857142857 0.9996296199678247 ZNF236, ZNF695, ZNF532, ZNF770, PRDM5, ZNF74 1024 293 19113 0.3822192299488055 1.0 1.0 100.0 Annotation Cluster 272 Enrichment Score: 0.017610905848870064 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008202~steroid metabolic process 8 0.7142857142857143 0.9360337145468665 CYP3A4, CYP3A5, CYP51A1, ATP8B1, DHRS9, LSS, COMT, VLDLR 751 202 13528 0.7133986368010969 1.0 0.999987631500865 100.0 GOTERM_BP_FAT GO:0008203~cholesterol metabolic process 3 0.26785714285714285 0.9667367907061357 CYP51A1, LSS, VLDLR 751 92 13528 0.5873907254095988 1.0 0.9999985829587593 100.0 GOTERM_BP_FAT GO:0016125~sterol metabolic process 3 0.26785714285714285 0.9785151275664299 CYP51A1, LSS, VLDLR 751 101 13528 0.5350489776008227 1.0 0.9999996750911051 100.0 Annotation Cluster 273 Enrichment Score: 0.016709073478917397 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006366~transcription from RNA polymerase II promoter 9 0.8035714285714285 0.9513306667068645 MAZ, TAF1A, TAF6, POLR2J, BMPR2, PARP1, STAT1, FEV, NFATC1 751 234 13528 0.692819829970296 1.0 0.9999947244240649 100.0 GOTERM_BP_FAT GO:0006351~transcription, DNA-dependent 11 0.9821428571428571 0.9658733872507458 MAZ, TAF1A, TAF6, POLR2J, BMPR2, TFB2M, PARP1, STAT1, GTF3C3, FEV, NFATC1 751 292 13528 0.6785838060667968 1.0 0.9999984908219448 100.0 GOTERM_BP_FAT GO:0032774~RNA biosynthetic process 11 0.9821428571428571 0.9696635770626534 MAZ, TAF1A, TAF6, POLR2J, BMPR2, TFB2M, PARP1, STAT1, GTF3C3, FEV, NFATC1 751 296 13528 0.6694137546334616 1.0 0.9999989557374873 100.0 Annotation Cluster 274 Enrichment Score: 0.016377830632183645 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS heparin-binding 3 0.26785714285714285 0.8682442212493822 F11, SERPIND1, LRPAP1 1027 65 19235 0.8644296307392705 1.0 0.9936700862673158 99.99999999998644 GOTERM_MF_FAT GO:0008201~heparin binding 3 0.26785714285714285 0.9811138939264971 F11, SERPIND1, LRPAP1 725 103 12983 0.5215801807833947 1.0 0.9999998881994081 100.0 GOTERM_MF_FAT GO:0005539~glycosaminoglycan binding 4 0.35714285714285715 0.9863350644815201 F11, SERPIND1, NLRP3, LRPAP1 725 140 12983 0.5116453201970442 1.0 0.9999999550635262 100.0 GOTERM_MF_FAT GO:0001871~pattern binding 4 0.35714285714285715 0.9928017256350531 F11, SERPIND1, NLRP3, LRPAP1 725 154 12983 0.4651321092700403 1.0 0.9999999957183793 100.0 GOTERM_MF_FAT GO:0030247~polysaccharide binding 4 0.35714285714285715 0.9928017256350531 F11, SERPIND1, NLRP3, LRPAP1 725 154 12983 0.4651321092700403 1.0 0.9999999957183793 100.0 Annotation Cluster 275 Enrichment Score: 0.015101573382265742 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003700~transcription factor activity 51 4.553571428571428 0.7573215254068195 TBX20, HIRA, ZKSCAN1, BUD31, ZKSCAN5, FEV, ZNF394, GATAD1, ZNF496, BRD8, EGR1, CTBP1, L3MBTL4, RAX, DMRT3, DMRT1, ZHX3, DMRT2, ZNF3, ZNF236, TGIF1, TGIF2, CUX1, GLIS3, HMGB2, ATF2, STAT4, CIR1, NKX1-1, HAND2, TSC22D4, ZSCAN21, EWSR1, NFATC1, TBX6, LZTR1, TAF6, MAFB, TBX1, GSC2, STAT1, DLX2, DLX1, ADNP2, RNF4, CSRNP3, DLX6, DMTF1, DLX5, RFX3, SCAND1 725 975 12983 0.9367045092838198 1.0 0.9996725257774411 99.99999997112711 GOTERM_MF_FAT GO:0030528~transcription regulator activity 69 6.1607142857142865 0.9798525409705432 TAF1A, TBX20, HIRA, ZKSCAN1, BUD31, ZKSCAN5, FEV, SAP30, BHLHA15, TFB2M, ZNF394, GATAD1, ZNF496, BRD8, EGR1, CTBP1, L3MBTL4, RAX, DMRT3, HDAC10, DMRT1, ZHX3, DMRT2, ZNF3, MXD4, ZNF236, MED15, NAB1, PRDM5, TGIF1, TGIF2, LRCH4, CUX1, SMARCA2, THAP7, GLIS3, HMGB2, NOSTRIN, ATF2, STAT4, CIR1, NKX1-1, ZSCAN21, HAND2, TSC22D4, BCL2, HNRNPD, EWSR1, NFATC1, GTF3C3, TBX6, LZTR1, TAF6, HTT, MAFB, TBX1, GSC2, STAT1, DLX2, ADNP2, DLX1, CSRNP3, RNF4, DMTF1, DLX6, SP3, DLX5, RFX3, SCAND1 725 1512 12983 0.8172112753147235 1.0 0.9999998651922445 100.0 SP_PIR_KEYWORDS dna-binding 81 7.232142857142858 0.9873490017037516 KIF22, TAF1A, ZNF532, TBX20, ZNF12, ZKSCAN1, PHF20, ZKSCAN5, FEV, SAP30, TOP1, MAZ, MCM7, BHLHA15, ZNF394, LBR, ZNF496, POLL, EGR1, RAX, DMRT3, DMRT1, DMRT2, ZHX3, HNRNPU, ZNF3, MXD4, ZNF236, ZNF789, UHRF2, PRDM5, TGIF1, TGIF2, LIN54, CUX1, NHEJ1, SMARCA2, TOP3B, THAP7, ZNF519, GLIS3, ZNF516, HMGB2, THAP9, AHCTF1, ZNF655, ATF2, PEG10, STAT4, NKX1-1, ZSCAN21, HAND2, HNRNPD, POLN, ZNF74, ZNF124, CHD6, EWSR1, NFATC1, GTF3C3, EXO1, TBX6, MAFB, ZNF770, ZNF669, TBX1, GSC2, STAT1, SALL3, ZNF670, DLX2, ADNP2, DLX1, CSRNP3, DMTF1, DLX6, SP3, DLX5, SP5, RFX3, PARP1 1027 1868 19235 0.8121381166742075 1.0 0.9999200811416024 100.0 GOTERM_MF_FAT GO:0003677~DNA binding 109 9.732142857142858 0.9887794701480684 HIRA, TOP1, FAM171B, BHLHA15, PMS2, ZNF394, DNAJC2, PMS1, POLL, MCM3AP, L3MBTL4, ZHX3, POLR2J2, POLR2J3, ZNF3, EEPD1, HNRNPU, ZNF236, ZNF789, UHRF2, PRDM5, TGIF1, TGIF2, SMARCA2, ZNF519, ZNF516, HMGB2, TNRC18, AHCTF1, NOSTRIN, CXXC5, ATF2, PEG10, NKX1-1, HNRNPD, POLN, OTUD7A, ZNF74, ZNF124, EWSR1, TAF6, MAFB, GSC2, SALL3, DLX2, DLX1, CSRNP3, RNF4, ZNF316, DLX6, DMTF1, DLX5, RFX3, HSPD1, PARP1, KIF22, TAF1A, ZNF532, TBX20, ZNF12, ZKSCAN1, PHF20, BUD31, ZKSCAN5, FEV, MAZ, MCM7, PMS2CL, GATAD1, LBR, ZNF496, BRD8, EGR1, CTBP1, RAX, DMRT3, DMRT1, DMRT2, MXD4, CUX1, NHEJ1, TOP3B, THAP7, GLIS3, THAP9, POLR2J, ABI2, ZNF655, STAT4, CHD1L, CIR1, ZSCAN21, TSC22D4, HAND2, CHD6, NFATC1, GTF3C3, EXO1, TBX6, LZTR1, ZNF770, TBX1, ZNF669, STAT1, ZNF670, ADNP2, SP3, ZBED4, SP5, SCAND1 725 2331 12983 0.8373774759981657 1.0 0.9999999776100855 100.0 GOTERM_BP_FAT GO:0006355~regulation of transcription, DNA-dependent 79 7.053571428571429 0.9912178723693262 NIF3L1, TBX20, HIRA, ZNF12, ZKSCAN1, BUD31, ZKSCAN5, FEV, SAP30, TRAK2, BHLHA15, TFB2M, ZNF394, GATAD1, ZNF496, BRD8, IHH, EGR1, L3MBTL4, CTBP1, RAX, DMRT3, SLA2, RBL1, HDAC10, DMRT1, DMRT2, ZHX3, ZNF3, MXD4, ZNF236, ZNF789, MED15, NAB1, TGIF1, TGIF2, CUX1, SMARCA2, ZNF519, GLIS3, HMGB2, HAT1, NOSTRIN, ZNF655, ATF2, STAT4, CIR1, ZNF695, NKX1-1, ZSCAN21, HAND2, TSC22D4, HNRNPD, ZNF74, ZNF124, CHD6, EWSR1, NFATC1, EPO, TBX6, MAFB, ZNF669, TBX1, GSC2, STAT1, ZNF670, DLX2, ADNP2, DLX1, CSRNP3, RNF4, ZNF316, DMTF1, DLX6, SP3, DLX5, RFX3, SCAND1, IL2 751 1773 13528 0.8026237624134168 1.0 0.9999999853504552 100.0 GOTERM_BP_FAT GO:0051252~regulation of RNA metabolic process 81 7.232142857142858 0.9912477141837553 NIF3L1, TBX20, HIRA, ZNF12, ZKSCAN1, BUD31, ZKSCAN5, FEV, SAP30, TRAK2, BHLHA15, TFB2M, ZNF394, GATAD1, ZNF496, BRD8, IHH, EGR1, L3MBTL4, CTBP1, RAX, DMRT3, SLA2, RBL1, HDAC10, DMRT1, DMRT2, ZHX3, HNRNPU, ZNF3, MXD4, ZNF236, ZNF789, MED15, NAB1, TGIF1, TGIF2, CUX1, SMARCA2, CALCR, ZNF519, GLIS3, HMGB2, HAT1, NOSTRIN, ZNF655, ATF2, STAT4, CIR1, ZNF695, NKX1-1, ZSCAN21, HAND2, TSC22D4, HNRNPD, ZNF74, ZNF124, CHD6, EWSR1, NFATC1, EPO, TBX6, MAFB, ZNF669, TBX1, GSC2, STAT1, ZNF670, DLX2, ADNP2, DLX1, CSRNP3, RNF4, ZNF316, DMTF1, DLX6, SP3, DLX5, RFX3, SCAND1, IL2 751 1813 13528 0.8047868515816016 1.0 0.999999985175122 100.0 SP_PIR_KEYWORDS Transcription 87 7.767857142857143 0.996114311313065 TAF1A, ZNF532, TBX20, HIRA, ZNF12, ZKSCAN1, PHF20, ZKSCAN5, FEV, SAP30, BZW1, MAZ, MCM7, CDCA7, BHLHA15, ACTR5, TFB2M, ZNF394, ZNF496, BRD8, EGR1, CTBP1, RAX, DMRT3, RBL1, HDAC10, DMRT1, DMRT2, ZHX3, LPIN2, POLR2J2, POLR2J3, ZNF3, MXD4, ZNF236, ZNF789, MED15, PRDM6, PRDM5, NAB1, TGIF1, TGIF2, LIN54, RBM39, CUX1, SMARCA2, THAP7, ZNF519, GLIS3, ZNF516, POLR2J, ZNF655, ATF2, STAT4, CIR1, ZNF695, ZSCAN21, HAND2, TSC22D4, HNRNPD, ACTL6B, ZNF74, ZNF124, KDM3B, CHD6, EWSR1, GTF3C3, NFATC1, TBX6, TAF6, MAFB, ZNF770, TBX1, ZNF669, STAT1, SALL3, ZNF670, ADNP2, CSRNP3, SRFBP1, RNF4, DMTF1, SP3, SP5, KDM4C, RFX3, TRIP6, PARP1 1027 2071 19235 0.7867937488862988 1.0 0.999993146715515 100.0 SP_PIR_KEYWORDS transcription regulation 84 7.5 0.9970893665722123 TAF1A, ZNF532, TBX20, HIRA, ZNF12, ZKSCAN1, PHF20, ZKSCAN5, FEV, SAP30, BZW1, MAZ, MCM7, CDCA7, BHLHA15, ACTR5, TFB2M, ZNF394, ZNF496, BRD8, EGR1, CTBP1, RAX, DMRT3, RBL1, HDAC10, DMRT1, DMRT2, ZHX3, LPIN2, ZNF3, MXD4, ZNF236, ZNF789, MED15, PRDM6, PRDM5, NAB1, TGIF1, TGIF2, LIN54, RBM39, CUX1, SMARCA2, THAP7, ZNF519, GLIS3, ZNF516, ZNF655, ATF2, STAT4, CIR1, NKX1-1, ZSCAN21, HAND2, TSC22D4, HNRNPD, ACTL6B, ZNF74, ZNF124, KDM3B, CHD6, EWSR1, NFATC1, TBX6, TAF6, MAFB, ZNF770, TBX1, ZNF669, STAT1, SALL3, ZNF670, ADNP2, CSRNP3, SRFBP1, RNF4, DMTF1, SP3, SP5, KDM4C, RFX3, TRIP6, PARP1 1027 2026 19235 0.7765359960244187 1.0 0.9999961283443586 100.0 GOTERM_BP_FAT GO:0045449~regulation of transcription 113 10.089285714285715 0.9993207483441262 HIRA, TLR3, CDCA7, TRAK2, BHLHA15, TFB2M, ZNF394, CCNA2, L3MBTL4, RBL1, HDAC10, ZHX3, ZNF3, MAPK1, ZNF236, ZNF789, MED15, PRDM6, PRDM5, TGIF1, TGIF2, LRCH4, SMARCA2, ZNF519, ZNF516, HMGB2, NOSTRIN, ATF2, NKX1-1, ZNF695, HNRNPD, ZNF74, ZNF124, EWSR1, TAF6, MAFB, MSTN, MALT1, GSC2, SALL3, DLX2, DLX1, CSRNP3, RNF4, ZNF316, DMTF1, DLX6, DLX5, RFX3, TAF1A, NIF3L1, ZNF532, TBX20, ZNF12, ZKSCAN1, PHF20, BUD31, ZKSCAN5, FEV, SAP30, BZW1, MAZ, MCM7, ACTR5, ATP8B1, GATAD1, ZNF496, BRD8, IHH, EGR1, CTBP1, RAX, SLA2, DMRT3, DMRT1, DMRT2, NLRP3, MXD4, GHRH, NAB1, LIN54, RBM39, CUX1, THAP7, GLIS3, HAT1, ZNF655, SUMO1, STAT4, CIR1, ZSCAN21, TSC22D4, HAND2, ACTL6B, KDM3B, CHD6, NFATC1, EPO, TBX6, ZNF770, FZD1, TBX1, ZNF669, STAT1, ZNF670, ADNP2, SRFBP1, SP3, SP5, KDM4C, JAK2, SCAND1, IL2 751 2601 13528 0.7825854134766357 1.0 0.9999999999988002 100.0 GOTERM_BP_FAT GO:0006350~transcription 86 7.678571428571429 0.9997090371162016 TAF1A, ZNF532, TBX20, HIRA, ZNF12, ZKSCAN1, PHF20, ZKSCAN5, FEV, SAP30, BZW1, MAZ, MCM7, CDCA7, BHLHA15, ACTR5, TFB2M, ZNF394, ZNF496, BRD8, EGR1, RAX, DMRT3, RBL1, HDAC10, DMRT1, DMRT2, ZHX3, POLR2J2, POLR2J3, ZNF3, MXD4, ZNF236, ZNF789, MED15, PRDM6, PRDM5, NAB1, TGIF1, TGIF2, LIN54, RBM39, CUX1, SMARCA2, THAP7, ZNF519, GLIS3, ZNF516, POLR2J, BMPR2, AHCTF1, ZNF655, ATF2, STAT4, CIR1, ZNF695, ZSCAN21, HAND2, TSC22D4, HNRNPD, ACTL6B, ZNF74, ZNF124, KDM3B, CHD6, EWSR1, GTF3C3, NFATC1, TBX6, TAF6, MAFB, ZNF770, TBX1, ZNF669, STAT1, SALL3, ZNF670, ADNP2, CSRNP3, SRFBP1, RNF4, DMTF1, SP3, SP5, KDM4C, RFX3, PARP1 751 2101 13528 0.7373370489355459 1.0 0.9999999999999485 100.0 Annotation Cluster 276 Enrichment Score: 0.012037031336491156 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007156~homophilic cell adhesion 5 0.4464285714285714 0.9371365138597291 CDH20, PTPRM, CDH19, PCDH10, PTPRT 751 131 13528 0.6875311289781563 1.0 0.9999882884870671 100.0 UP_SEQ_FEATURE domain:Cadherin 5 3 0.26785714285714285 0.9660476276359653 CDH20, CDH19, PCDH10 1024 95 19113 0.5894222861842106 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Cadherin 4 3 0.26785714285714285 0.9755042491403595 CDH20, CDH19, PCDH10 1024 102 19113 0.5489717371323529 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Cadherin 3 3 0.26785714285714285 0.9755042491403595 CDH20, CDH19, PCDH10 1024 102 19113 0.5489717371323529 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Cadherin 2 3 0.26785714285714285 0.9787262860318915 CDH20, CDH19, PCDH10 1024 105 19113 0.5332868303571429 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Cadherin 1 3 0.26785714285714285 0.9787262860318915 CDH20, CDH19, PCDH10 1024 105 19113 0.5332868303571429 1.0 1.0 100.0 INTERPRO IPR002126:Cadherin 3 0.26785714285714285 0.9843031143752943 CDH20, CDH19, PCDH10 920 108 16659 0.5029891304347827 1.0 0.9999999999998864 100.0 SMART SM00112:CA 3 0.26785714285714285 0.9862628079143623 CDH20, CDH19, PCDH10 513 108 9079 0.49160710418020354 1.0 0.999999907659476 100.0 Annotation Cluster 277 Enrichment Score: 0.009860223883125706 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051173~positive regulation of nitrogen compound metabolic process 28 2.5 0.9524680155583247 CSF2, GLIS3, HMGB2, NIF3L1, FAM175A, TBX20, COMT, FEV, HAND2, BHLHA15, ZSCAN21, CCNA2, IHH, EPO, EGR1, IL3, BRCC3, MAFB, MSTN, TBX1, DLX2, MAPK1, RNF4, CSRNP3, GHRH, JAK2, SMARCA2, IL2 751 644 13528 0.7831876338794651 1.0 0.9999949404841374 100.0 GOTERM_BP_FAT GO:0010628~positive regulation of gene expression 24 2.142857142857143 0.9690172574775565 EGR1, CSF2, IL3, GLIS3, HMGB2, NIF3L1, MAFB, TBX20, MSTN, TBX1, FEV, MAPK1, DLX2, RNF4, CSRNP3, ZSCAN21, BHLHA15, GHRH, HAND2, CCNA2, SMARCA2, IL2, IHH, EPO 751 581 13528 0.744095652153984 1.0 0.9999989088794301 100.0 GOTERM_BP_FAT GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 26 2.3214285714285716 0.9694563645792059 CSF2, GLIS3, HMGB2, NIF3L1, FAM175A, TBX20, FEV, HAND2, BHLHA15, ZSCAN21, CCNA2, IHH, EPO, EGR1, IL3, BRCC3, MAFB, MSTN, TBX1, DLX2, MAPK1, RNF4, CSRNP3, GHRH, SMARCA2, IL2 751 624 13528 0.750554815801154 1.0 0.9999989482075009 100.0 GOTERM_BP_FAT GO:0010604~positive regulation of macromolecule metabolic process 37 3.303571428571429 0.9718560799761266 CSF2, GLIS3, HMGB2, NIF3L1, FAM175A, BTRC, TBX20, BMPR2, TLR3, FEV, ZSCAN21, HAND2, BHLHA15, BCL2, KLKB1, CCNA2, EPO, IHH, EGR1, IL3, BRCC3, MAFB, MSTN, CDC23, TBX1, IL21, BOLL, MAPK1, DLX2, VEGFC, CSRNP3, RNF4, GHRH, PSMC2, JAK2, SMARCA2, IL2 751 857 13528 0.7777044065710907 1.0 0.9999991912320304 100.0 GOTERM_BP_FAT GO:0010557~positive regulation of macromolecule biosynthetic process 27 2.410714285714286 0.9747214498194529 CSF2, GLIS3, HMGB2, NIF3L1, TBX20, TLR3, FEV, HAND2, BHLHA15, ZSCAN21, CCNA2, IHH, EPO, EGR1, IL3, MAFB, MSTN, TBX1, IL21, BOLL, DLX2, MAPK1, RNF4, CSRNP3, GHRH, SMARCA2, IL2 751 654 13528 0.7436689918029783 1.0 0.999999424407356 100.0 GOTERM_BP_FAT GO:0031328~positive regulation of cellular biosynthetic process 28 2.5 0.979532148786978 CSF2, GLIS3, HMGB2, NIF3L1, TBX20, TLR3, FEV, HAND2, BHLHA15, ZSCAN21, CCNA2, IHH, EPO, EGR1, IL3, MAFB, MSTN, TBX1, IL21, BOLL, DLX2, MAPK1, RNF4, CSRNP3, GHRH, JAK2, SMARCA2, IL2 751 685 13528 0.7363107098078475 1.0 0.9999997192700779 100.0 GOTERM_BP_FAT GO:0045941~positive regulation of transcription 22 1.9642857142857142 0.9830013434958828 EGR1, GLIS3, HMGB2, NIF3L1, MAFB, TBX20, MSTN, TBX1, FEV, MAPK1, DLX2, RNF4, CSRNP3, ZSCAN21, BHLHA15, GHRH, HAND2, CCNA2, SMARCA2, IL2, IHH, EPO 751 564 13528 0.7026470616010804 1.0 0.9999998540503813 100.0 GOTERM_BP_FAT GO:0009891~positive regulation of biosynthetic process 28 2.5 0.9835574778005476 CSF2, GLIS3, HMGB2, NIF3L1, TBX20, TLR3, FEV, HAND2, BHLHA15, ZSCAN21, CCNA2, IHH, EPO, EGR1, IL3, MAFB, MSTN, TBX1, IL21, BOLL, DLX2, MAPK1, RNF4, CSRNP3, GHRH, JAK2, SMARCA2, IL2 751 695 13528 0.7257163111055763 1.0 0.9999998687729109 100.0 GOTERM_BP_FAT GO:0045944~positive regulation of transcription from RNA polymerase II promoter 13 1.1607142857142858 0.9869831494866851 EGR1, GLIS3, HMGB2, MAFB, TBX1, DLX2, CSRNP3, RNF4, BHLHA15, HAND2, SMARCA2, IHH, IL2 751 371 13528 0.6311943464419408 1.0 0.999999944167424 100.0 GOTERM_BP_FAT GO:0045893~positive regulation of transcription, DNA-dependent 17 1.5178571428571428 0.9911138394027639 EGR1, GLIS3, HMGB2, NIF3L1, MAFB, TBX20, TBX1, DLX2, RNF4, CSRNP3, BHLHA15, HAND2, ZSCAN21, SMARCA2, IL2, IHH, EPO 751 477 13528 0.6419839933896663 1.0 0.9999999850543603 100.0 GOTERM_BP_FAT GO:0051254~positive regulation of RNA metabolic process 17 1.5178571428571428 0.9920625388741685 EGR1, GLIS3, HMGB2, NIF3L1, MAFB, TBX20, TBX1, DLX2, RNF4, CSRNP3, BHLHA15, HAND2, ZSCAN21, SMARCA2, IL2, IHH, EPO 751 481 13528 0.6366452491618937 1.0 0.9999999895160839 100.0 Annotation Cluster 278 Enrichment Score: 0.009711856224617657 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR011598:Helix-loop-helix DNA-binding 3 0.26785714285714285 0.9501517199417375 BHLHA15, HAND2, MXD4 920 84 16659 0.6467003105590061 1.0 0.9999999998694755 100.0 UP_SEQ_FEATURE DNA-binding region:Basic motif 5 0.4464285714285714 0.975533493645906 BHLHA15, HAND2, MAFB, MXD4, ATF2 1024 161 19113 0.5796595982142857 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Helix-loop-helix motif 3 0.26785714285714285 0.9861157990960203 BHLHA15, HAND2, MXD4 1024 114 19113 0.49118523848684215 1.0 1.0 100.0 INTERPRO IPR001092:Basic helix-loop-helix dimerisation region bHLH 3 0.26785714285714285 0.9883201620044467 BHLHA15, HAND2, MXD4 920 114 16659 0.4765160183066361 1.0 0.9999999999999838 100.0 SMART SM00353:HLH 3 0.26785714285714285 0.9898741955246179 BHLHA15, HAND2, MXD4 513 114 9079 0.465733046065456 1.0 0.9999999630022077 100.0 Annotation Cluster 279 Enrichment Score: 0.0013675470029360605 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006006~glucose metabolic process 4 0.35714285714285715 0.992128096576938 PDK1, ALDOA, ACN9, G6PC2 751 153 13528 0.47093635501248887 1.0 0.999999989581167 100.0 GOTERM_BP_FAT GO:0019318~hexose metabolic process 4 0.35714285714285715 0.9987464327128094 PDK1, ALDOA, ACN9, G6PC2 751 192 13528 0.375277407900577 1.0 0.9999999999883695 100.0 GOTERM_BP_FAT GO:0005996~monosaccharide metabolic process 4 0.35714285714285715 0.9997107658873036 PDK1, ALDOA, ACN9, G6PC2 751 222 13528 0.32456424467076933 1.0 0.9999999999999475 100.0